GO:0030216

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Name keratinocyte differentiation
Categary Process
Go Slim No
Go Link GO:0030216
Unique Molecular Interactions 609
Total Molecular Interactions 857
Total Single Events 6365
Pain Genes Associated 44

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for keratinocyte differentiation. They are ordered first by their pain relevance and then by number of times they were reported for keratinocyte differentiation. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT182124 Binding of IRF6 and TLR4 14 0.10 16.11 4.65
2 INT155891 Nps Negative_regulation of Positive_regulation of Casp3 1 0.27 0.17 3.48
3 INT180984 IRF6 Positive_regulation of Localization of IL8 7 0.11 2.13 3.47
4 INT287746 Anxa1 Positive_regulation of Gene_expression of Lpar1 1 0.07 1.72 2.46
5 INT106750 Pes1 Negative_regulation of Positive_regulation of Casp3 3 0.23 0 2.35
6 INT85252 Negative_regulation of Chi3l1 Positive_regulation of Casp3 1 0.01 0 2.26
7 INT85251 Chi3l1 Positive_regulation of Casp3 1 0.01 0 2.25
8 INT106753 Pes1 Negative_regulation of Gene_expression of Casp3 2 0.12 0 2.19
9 INT77807 Edn1 Positive_regulation of Gene_expression of Ptgs2 1 0.33 0.53 2.1
10 INT88883 IRF6 Positive_regulation of Nfkb1 1 0.11 0.53 2.01
11 INT217042 IRF6 Positive_regulation of TNF 4 0.27 3.03 1.95
12 INT146587 Npff Negative_regulation of Positive_regulation of Casp3 1 0.05 0.18 1.92
13 INT146586 Npff Negative_regulation of Gene_expression of Casp3 1 0.06 0.18 1.92
14 INT346217 Braf Positive_regulation of Phosphorylation of Map2k1 1 0.22 3.23 1.72
15 INT93470 Notch1 Positive_regulation of Localization of Prkcg 2 0.09 0.31 1.65
16 INT106751 Pes1 Negative_regulation of Casp3 2 0.23 0 1.54
17 INT137657 Gorasp2 Regulation of Binding of Casp3 1 0.09 0 1.52
18 INT293009 IRF6 Positive_regulation of Positive_regulation of CA2 1 0.04 0.66 1.49
19 INT318491 IRF6 Positive_regulation of FPR2 1 0.10 6.14 1.44
20 INT294775 IRF6 Positive_regulation of TLR4 6 0.08 2.04 1.32
21 INT83707 Acyp2-ps1 Regulation of Casp3 1 0.17 0 1.28
22 INT83705 Acyp2-ps1 Regulation of Positive_regulation of Casp3 1 0.17 0 1.28
23 INT145315 D2Mit212 Regulation of Casp3 1 0.00 0 1.24
24 INT145316 D2Mit212 Regulation of Positive_regulation of Casp3 1 0.00 0 1.24
25 INT145317 D2Mit212 Positive_regulation of Casp3 1 0.01 0 1.22
26 INT77806 Edn1 Regulation of Gene_expression of Ptgs2 1 0.29 1.24 1.22
27 INT93435 Binding of Casp3 and Cckbr 1 0.06 0.15 1.18
28 INT289465 IRF6 Positive_regulation of IL1B 3 0.05 0.9 1.16
29 INT155892 Nps Negative_regulation of Casp3 1 0.27 0.06 1.16
30 INT195117 Ptgs2 Positive_regulation of Gene_expression of Il6 1 0.10 3.26 1.16
31 INT65373 Notch1 Regulation of Oprd1 1 0.09 0 1.16
32 INT155890 Nps Negative_regulation of Gene_expression of Casp3 1 0.27 0.05 1.15
33 INT112607 DNAJC15 Negative_regulation of Positive_regulation of Casp3 1 0.03 0.14 1.12
34 INT159235 H2-M3 Negative_regulation of Casp3 1 0.05 0 1.12
35 INT159236 H2-M3 Positive_regulation of Casp3 1 0.06 0 1.12
36 INT155894 Nps Regulation of Gene_expression of Casp3 1 0.33 0.07 1.09
37 INT74460 GTS Negative_regulation of Casp3 1 0.04 0.37 1.08
38 INT159237 Gpm6a Positive_regulation of Casp3 1 0.03 0 1.07
39 INT185373 IRF6 Positive_regulation of Gene_expression of TLR2 1 0.08 2.96 1.04
40 INT307047 Foxm1 Positive_regulation of Casp3 1 0.11 0.06 1.03
41 INT318490 IRF6 Positive_regulation of LTB4R 1 0.01 4.39 1.03
42 INT88881 Negative_regulation of IRF6 Positive_regulation of Nfkb1 1 0.09 0.27 1.03
43 INT293014 IRF6 Positive_regulation of Localization of CA2 1 0.04 0.71 1.02
44 INT74934 Regulation of IRF6 Positive_regulation of Nfkb1 1 0.01 0.52 1.02
45 INT88887 IRF6 Positive_regulation of Transcription of Nos2 1 0.21 0.27 1.02
46 INT74933 IRF6 Positive_regulation of Nfkb1 1 0.02 0.52 1.01
47 INT98556 Oprm1 Positive_regulation of Casp3 1 0.38 0.36 1.01
48 INT88884 IRF6 Regulation of Nos2 1 0.12 0.26 1
49 INT88886 IRF6 Positive_regulation of Nos2 1 0.22 0.26 1
50 INT88888 Regulation of IRF6 Positive_regulation of Nos2 1 0.20 0.26 1
51 INT60213 Binding of Ptgs1 and Ptgs2 2 0.37 0.5 0.97
52 INT133616 Map2k1 Regulation of Fadd 1 0.04 0.29 0.97
53 INT133614 Map2k1 Regulation of Daxx 1 0.02 0.29 0.97
54 INT133615 Regulation of Map2k1 Regulation of Fadd 1 0.04 0.29 0.97
55 INT98180 Aap Positive_regulation of Positive_regulation of Casp3 1 0.00 1.08 0.97
56 INT166842 Binding of ANXA1 and Nfkb1 1 0.37 1.64 0.95
57 INT61037 Och Positive_regulation of Ptgs1 1 0.00 0 0.95
58 INT155893 Nps Regulation of Casp3 1 0.24 0.08 0.95
59 INT1654 Pomc Regulation of DSP 1 0.03 0 0.94
60 INT285418 IRF6 Positive_regulation of Localization of IL6 3 0.05 0.66 0.93
61 INT227325 Binding of IRF6 and Cd14 1 0.01 2.51 0.93
62 INT220031 Casp3 Positive_regulation of Gene_expression of Nos3 1 0.04 0 0.92
63 INT289461 IRF6 Positive_regulation of ICAM1 1 0.08 0.61 0.91
64 INT135446 Map2k1 Positive_regulation of Mapk3 1 0.54 0.25 0.91
65 INT343834 Binding of CD14 and IRF6 1 0.02 2.08 0.9
66 INT148806 Diablo Positive_regulation of Positive_regulation of Casp3 1 0.03 1.02 0.89
67 INT147885 Negative_regulation of Slc6a3 Positive_regulation of Positive_regulation of Casp3 1 0.13 0 0.88
68 INT343847 IRF6 Positive_regulation of TBCE 1 0.01 1.11 0.87
69 INT97795 IRF6 Positive_regulation of Localization of TNF 3 0.09 1.57 0.86
70 INT307045 Tmie Negative_regulation of Positive_regulation of Casp3 1 0.01 0.29 0.85
71 INT149628 Il1b Regulation of Gene_expression of Ptgs2 1 0.30 0.84 0.84
72 INT188567 IRF6 Positive_regulation of Gene_expression of CD28 1 0.05 1.28 0.82
73 INT116250 Vta1 Positive_regulation of Casp3 1 0.01 0 0.82
74 INT56236 Casp3 Positive_regulation of Gene_expression of RT1-Cl 1 0.00 0.45 0.82
75 INT255321 Binding of 2E and Sprr1a 1 0.02 0 0.81
76 INT88885 IRF6 Positive_regulation of Gene_expression of Nos2 1 0.21 0.1 0.81
77 INT255328 Binding of Nav1 and Sprr1a 1 0.01 0 0.81
78 INT286346 IRF6 Positive_regulation of IL8 3 0.03 0.88 0.8
79 INT33059 Dsp Negative_regulation of Localization of LH 1 0.18 0 0.8
80 INT64067 Tp63 Negative_regulation of Localization of Gh1 1 0.08 0.07 0.76
81 INT221415 IRF6 Positive_regulation of Gene_expression of IL10 2 0.05 1.73 0.75
82 INT307044 Tmie Regulation of Casp3 1 0.01 0 0.75
83 INT142847 IRF6 Positive_regulation of IL6 5 0.07 1.09 0.73
84 INT114860 Negative_regulation of Insrr Positive_regulation of Casp3 1 0.02 0.71 0.73
85 INT220033 Casp3 Positive_regulation of Gene_expression of Nos1 1 0.05 0.52 0.72
86 INT128684 Binding of TGM1 and RETNLB 1 0.00 2.46 0.72
87 INT134476 Cdk5 Regulation of Map2k1 1 0.69 0.88 0.71
88 INT104835 IRF6 Positive_regulation of IL10 4 0.32 0.91 0.69
89 INT64070 Tp63 Regulation of Ghrh 1 0.04 0.06 0.69
90 INT64068 Tp63 Regulation of Fdft1 1 0.00 0.06 0.69
91 INT151559 Atp2a1 Negative_regulation of Positive_regulation of CASP3 1 0.06 0.68 0.66
92 INT343851 Positive_regulation of Binding of IRF6 and TLR4 1 0.07 1.96 0.66
93 INT129694 Binding of Casp3 and Casp9 1 0.35 0.86 0.65
94 INT124477 MAP2K1 Positive_regulation of Positive_regulation of MAPK1 1 0.12 1.35 0.65
95 INT318476 IRF6 Positive_regulation of Localization of RETNLB 1 0.00 1.42 0.65
96 INT351445 Binding of Vta1 and Positive_regulation of Casp3 1 0.01 0.39 0.64
97 INT103870 IRF6 Positive_regulation of Hmox1 1 0.14 0.83 0.64
98 INT64956 IRF6 Positive_regulation of Gene_expression of IL6 4 0.19 1.4 0.63
99 INT148381 UFM1 Positive_regulation of JAG1 1 0.00 1.13 0.63
100 INT106754 Pes1 Positive_regulation of Casp3 1 0.13 0 0.63
101 INT106752 Negative_regulation of Pes1 Positive_regulation of Casp3 1 0.12 0 0.63
102 INT11558 POMC Positive_regulation of CASP3 1 0.05 0 0.62
103 INT115592 IRF6 Positive_regulation of Gene_expression of FAS 1 0.34 0.34 0.62
104 INT83706 Acyp2-ps1 Positive_regulation of Casp3 1 0.11 0 0.61
105 INT55672 Ptgs1 Positive_regulation of Gene_expression of Ik 1 0.03 0.75 0.61
106 INT85489 IRF6 Negative_regulation of PLOD1 1 0.01 0.16 0.61
107 INT85488 Negative_regulation of IRF6 Negative_regulation of PLOD1 1 0.01 0.16 0.61
108 INT114505 Negative_regulation of Hmmr Positive_regulation of Casp3 1 0.01 0.72 0.6
109 INT114506 Hmmr Positive_regulation of Casp3 1 0.01 0.72 0.6
110 INT133320 Penk Negative_regulation of Gene_expression of Casp3 1 0.11 0.91 0.6
111 INT163376 RYBP Positive_regulation of Gene_expression of Casp3 2 0.01 0.57 0.59
112 INT318481 IRF6 Positive_regulation of Gene_expression of FPR2 1 0.14 5.09 0.59
113 INT318487 Negative_regulation of IRF6 Positive_regulation of FPR2 1 0.09 1.39 0.59
114 INT263454 Negative_regulation of IRF6 Positive_regulation of TNF 1 0.12 0.49 0.59
115 INT236783 IRF6 Negative_regulation of Gene_expression of TLR4 1 0.01 1.17 0.57
116 INT166840 Binding of Anxa1 and Nfkb1 1 0.26 0.82 0.56
117 INT254197 Mif Regulation of Ptgs2 1 0.02 1.08 0.55
118 INT286349 IRF6 Positive_regulation of Localization of IL10 1 0.03 1.22 0.55
119 INT112399 Olr897-ps Regulation of Gene_expression of Casp3 1 0.03 0 0.54
120 INT118082 APP Positive_regulation of Casp3 1 0.00 0.5 0.54
121 INT318478 Negative_regulation of IRF6 Positive_regulation of LTB4R 1 0.01 2.38 0.53
122 INT62898 Binding of Oprl1 and Dsp 1 0.35 0 0.52
123 INT116541 Binding of Ptgs2 and ZNF398 1 0.00 0.68 0.52
124 INT74517 Binding of Casp3 and Cnrip1 1 0.31 0 0.51
125 INT66188 Binding of ADRB2 and CDSN 1 0.01 0 0.51
126 INT343859 Binding of IRF6 and TBCE 1 0.01 1.1 0.51
127 INT97800 Gm5564 Regulation of IRF6 1 0.00 0.07 0.5
128 INT343825 IRF6 Regulation of Gene_expression of FUT1 1 0.00 1.74 0.5
129 INT234609 Binding of CASP3 and IMMT 1 0.00 0.5 0.5
130 INT217037 Binding of IRF6 and Il12a 1 0.01 0.08 0.5
131 INT169400 Negative_regulation of IRF6 Positive_regulation of Gene_expression of Il1b 1 0.50 0.62 0.5
132 INT289464 Negative_regulation of IRF6 Positive_regulation of ICAM1 1 0.07 0.31 0.5
133 INT84515 IRF6 Positive_regulation of Gene_expression of F2 1 0.02 0.15 0.49
134 INT289462 Negative_regulation of IRF6 Positive_regulation of IL1B 2 0.04 0.31 0.48
135 INT165078 Binding of CTSB and Notch1 1 0.00 1.08 0.48
136 INT127663 IRF6 Positive_regulation of PDE4A 1 0.14 0.76 0.48
137 INT289463 IRF6 Positive_regulation of Localization of IL1B 1 0.05 0.52 0.48
138 INT129551 Sag Negative_regulation of Gene_expression of Ptgs1 1 0.08 0.88 0.48
139 INT351446 Gria2 Negative_regulation of Casp3 1 0.02 0.37 0.47
140 INT217040 Negative_regulation of IRF6 Positive_regulation of CCL2 1 0.00 1.24 0.47
141 INT307048 Cnr1 Positive_regulation of Casp3 1 0.08 0 0.47
142 INT217039 IRF6 Positive_regulation of CCL2 1 0.00 1.24 0.47
143 INT193480 Binding of ABCA1 and IRF6 1 0.00 1.08 0.46
144 INT288265 Binding of FLG and NEUROG1 1 0.02 1.06 0.46
145 INT116926 Cpox Regulation of AKR1C3 1 0.01 0.28 0.45
146 INT103871 Negative_regulation of IRF6 Positive_regulation of Hmox1 1 0.12 0.61 0.45
147 INT84517 IRF6 Positive_regulation of TF 1 0.14 0.19 0.44
148 INT188564 IRF6 Positive_regulation of Gene_expression of PRF1 1 0.01 0.44 0.44
149 INT188565 IRF6 Regulation of Gene_expression of CD28 1 0.03 0.7 0.43
150 INT296237 Anxa1 Regulation of Gene_expression of Trpm8 1 0.03 0.57 0.43
151 INT296231 Anxa1 Regulation of Gene_expression of Trpa1 1 0.03 0.57 0.43
152 INT243682 IRF6 Positive_regulation of NEU2 1 0.01 0.18 0.43
153 INT343853 IRF6 Positive_regulation of PECAM1 1 0.00 0.53 0.43
154 INT188562 IRF6 Regulation of Gene_expression of PRF1 1 0.01 0.7 0.43
155 INT293007 IRF6 Positive_regulation of ELANE 1 0.00 0 0.42
156 INT296235 Trpm8 Regulation of Positive_regulation of Anxa1 1 0.03 0.62 0.41
157 INT57236 Casp3 Positive_regulation of Prl 1 0.09 0 0.41
158 INT84518 IRF6 Positive_regulation of Gene_expression of TF 1 0.14 0.09 0.41
159 INT57235 Casp3 Positive_regulation of Localization of Prl 1 0.15 0 0.4
160 INT343844 Binding of IRF6 and LY96 1 0.01 1.03 0.4
161 INT295478 IRF6 Positive_regulation of Positive_regulation of TLR4 2 0.20 0.78 0.39
162 INT346222 Positive_regulation of Braf Positive_regulation of Map2k1 1 0.15 0.67 0.39
163 INT106505 Binding of Ptgds and Ptgs2 1 0.01 0.93 0.39
164 INT188560 Negative_regulation of Binding of IRF6 and TLR4 1 0.04 0.58 0.38
165 INT318489 Positive_regulation of IRF6 Negative_regulation of Gene_expression of FPR2 1 0.09 1.18 0.38
166 INT318482 IRF6 Negative_regulation of Gene_expression of FPR2 1 0.09 1.18 0.38
167 INT52960 Casp3 Negative_regulation of Positive_regulation of Ltp 1 0.02 0 0.37
168 INT144044 IRF6 Positive_regulation of PTGES 1 0.10 0.43 0.37
169 INT291625 Binding of CSTA and RAPGEF5 1 0.03 4.81 0.37
170 INT145908 Pdyn Regulation of Positive_regulation of Casp3 1 0.14 0.94 0.37
171 INT286351 IL8 Positive_regulation of Gene_expression of IRF6 1 0.03 0.71 0.36
172 INT255804 DSP Negative_regulation of Gene_expression of Il6 1 0.01 0.36 0.36
173 INT286350 IL6 Positive_regulation of Gene_expression of IRF6 1 0.04 0.71 0.36
174 INT185379 Binding of IRF6 and TLR2 4 0.08 2.88 0.35
175 INT250781 IRF6 Positive_regulation of AMIGO2 1 0.02 1.25 0.35
176 INT318484 IRF6 Positive_regulation of Positive_regulation of LTB4R 1 0.01 1.38 0.35
177 INT144048 IRF6 Positive_regulation of Gene_expression of PTGES 1 0.12 0.46 0.35
178 INT318486 IRF6 Positive_regulation of Negative_regulation of FPR2 1 0.10 1.39 0.35
179 INT182126 IRF6 Positive_regulation of Gene_expression of SELE 1 0.03 0.86 0.34
180 INT122169 AKR1C3 Regulation of PPARG 1 0.45 0.26 0.33
181 INT124475 MAP2K1 Positive_regulation of Positive_regulation of CPOX 1 0.04 0.68 0.33
182 INT133021 IRF6 Positive_regulation of Gene_expression of IL8 1 0.11 0.51 0.32
183 INT76088 IFNA1 Positive_regulation of IRF6 1 0.19 0.18 0.31
184 INT76086 IRF6 Positive_regulation of ISYNA1 1 0.07 0.18 0.31
185 INT286708 Negative_regulation of Mapk1 Negative_regulation of Casp3 1 0.12 0 0.31
186 INT105437 IRF6 Positive_regulation of Localization of PTGER1 1 0.01 0.61 0.31
187 INT187523 IRF6 Positive_regulation of Gene_expression of Cpox 1 0.00 1.38 0.31
188 INT156087 Binding of AKR1C3 and Akr1c1 1 0.05 0.31 0.3
189 INT156083 Binding of AKR1C2 and AKR1C3 1 0.05 0.31 0.3
190 INT105438 IRF6 Positive_regulation of PTGER1 1 0.01 0.61 0.3
191 INT156084 Binding of PTGS2 and AKR1C3 1 0.02 0.31 0.3
192 INT156082 Binding of PTGS1 and AKR1C3 1 0.01 0.31 0.3
193 INT318480 IRF6 Positive_regulation of Gene_expression of LTB4R 1 0.01 1.63 0.29
194 INT287747 Anxa1 Positive_regulation of Lpar1 1 0.04 0 0.29
195 INT287748 Positive_regulation of Anxa1 Positive_regulation of Lpar1 1 0.04 0 0.29
196 INT166162 Ccr9 Negative_regulation of Positive_regulation of Casp3 1 0.18 1.49 0.28
197 INT237679 IRF6 Positive_regulation of MAPK8 1 0.00 0.56 0.28
198 INT294709 IRF6 Positive_regulation of Gene_expression of CCL2 1 0.08 0.14 0.28
199 INT193479 TLR2 Regulation of Binding of IRF6 1 0.04 0.75 0.28
200 INT243214 Myst2 Negative_regulation of Gene_expression of Ptgs2 1 0.01 1.4 0.28

Single Events

The table below shows the top 100 pain related interactions that have been reported for keratinocyte differentiation. They are ordered first by their pain relevance and then by number of times they were reported in keratinocyte differentiation. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT22548 Positive_regulation of Casp3 483 0.70 258.78 213.07
2 INT65600 Positive_regulation of Casp3 376 0.70 198.44 128.03
3 INT14151 Gene_expression of Casp3 311 0.78 140.26 120.68
4 INT940 Negative_regulation of Ptgs1 219 0.59 104.34 95.97
5 INT31116 Gene_expression of Casp3 192 0.78 78.21 57.43
6 INT52611 Negative_regulation of Ptgs2 142 0.59 66.31 52.71
7 INT22546 Positive_regulation of Gene_expression of Casp3 97 0.70 47.89 51.92
8 INT53083 Gene_expression of Ptgs2 153 0.78 90.04 50.39
9 INT49552 Negative_regulation of Positive_regulation of Casp3 76 0.55 36.04 44.78
10 INT27493 Negative_regulation of Casp3 114 0.56 56.89 44.63
11 INT11560 Positive_regulation of CASP3 236 0.70 184.33 39.38
12 INT65597 Negative_regulation of Casp3 69 0.59 39.19 29.32
13 INT65598 Negative_regulation of Positive_regulation of Casp3 45 0.59 18.36 28.59
14 INT22045 Gene_expression of IRF6 158 0.75 58.07 27.81
15 INT64499 Positive_regulation of IRF6 123 0.49 52.73 27.51
16 INT90313 Negative_regulation of Gene_expression of Casp3 57 0.57 22.23 26.77
17 INT9886 Gene_expression of Ptgs1 92 0.77 40.66 25.31
18 INT22549 Positive_regulation of Positive_regulation of Casp3 48 0.56 29.5 23.7
19 INT29704 Regulation of Casp3 51 0.56 22.13 22.79
20 INT97798 Localization of IRF6 86 0.73 33.27 20.94
21 INT78694 Positive_regulation of Gene_expression of Casp3 46 0.66 18.64 19.62
22 INT22547 Regulation of Gene_expression of Casp3 23 0.62 8.04 16.78
23 INT108588 Gene_expression of CASP3 126 0.78 84.49 16.2
24 INT78697 Negative_regulation of Gene_expression of Casp3 33 0.57 11.22 16.16
25 INT52696 Positive_regulation of Ptgs2 48 0.70 27.65 14.44
26 INT53080 Positive_regulation of Ptgs1 42 0.42 23.58 14.37
27 INT22046 Negative_regulation of IRF6 52 0.43 25.69 14.13
28 INT99586 Binding of IRF6 60 0.36 27.87 13.2
29 INT81626 Positive_regulation of Positive_regulation of Casp3 34 0.69 16.75 12.18
30 INT20457 Regulation of Ptgs1 23 0.48 11.63 11.56
31 INT53082 Positive_regulation of Gene_expression of Ptgs2 47 0.64 25.39 11.39
32 INT78695 Regulation of Casp3 24 0.44 9.43 10.48
33 INT29705 Regulation of Positive_regulation of Casp3 13 0.48 5.37 10.45
34 INT53081 Negative_regulation of Gene_expression of Ptgs2 29 0.59 15.83 10.39
35 INT62544 Gene_expression of Anxa1 21 0.47 13.56 9.71
36 INT105103 Regulation of Gene_expression of Casp3 11 0.39 3.15 9.22
37 INT52442 Binding of Ptgs1 16 0.35 9.05 8.78
38 INT78696 Regulation of Positive_regulation of Casp3 9 0.39 2.93 8.2
39 INT135443 Phosphorylation of Map2k1 11 0.80 2.44 8.01
40 INT171367 Phosphorylation of Map2k1 31 0.58 32.87 8
41 INT135441 Positive_regulation of Map2k1 15 0.67 6.6 7.87
42 INT98178 Localization of Casp3 32 0.65 21.01 7.77
43 INT102814 Negative_regulation of CASP3 46 0.43 28.54 6.94
44 INT102749 Positive_regulation of Positive_regulation of CASP3 32 0.67 26.07 6.93
45 INT93137 Negative_regulation of Map2k1 17 0.42 4.51 6.49
46 INT108585 Positive_regulation of Gene_expression of CASP3 35 0.70 28.37 6.45
47 INT76096 Positive_regulation of Gene_expression of IRF6 37 0.49 14.24 6.39
48 INT150417 Negative_regulation of Gene_expression of IRF6 20 0.41 11.48 6.28
49 INT57232 Binding of Casp3 22 0.36 9.42 6.2
50 INT134544 Negative_regulation of Positive_regulation of CASP3 23 0.57 18.48 5.95
51 INT112530 Localization of Ptgs2 13 0.70 7.77 5.86
52 INT52695 Regulation of Ptgs2 20 0.42 8.72 5.71
53 INT123726 Positive_regulation of Notch1 23 0.70 7.2 5.65
54 INT135440 Positive_regulation of Phosphorylation of Map2k1 5 0.49 1.32 5.22
55 INT138779 Positive_regulation of Localization of IRF6 25 0.45 11.51 4.51
56 INT69217 Gene_expression of Notch1 20 0.78 7.8 4.41
57 INT108086 Negative_regulation of AKR1C3 17 0.58 7.7 3.99
58 INT106065 Negative_regulation of MAP2K1 27 0.57 12.69 3.97
59 INT115773 Negative_regulation of Localization of Ptgs2 6 0.43 2.99 3.81
60 INT97799 Regulation of IRF6 23 0.26 6.54 3.75
61 INT88805 Protein_catabolism of CASP3 24 0.86 18.38 3.7
62 INT85497 Gene_expression of Anxa1 6 0.77 4.7 3.68
63 INT97126 Regulation of CASP3 9 0.40 8.15 3.6
64 INT67726 Gene_expression of Notch1 36 0.75 9.77 3.54
65 INT53200 Binding of Ptgs2 11 0.48 5.08 3.54
66 INT62678 Negative_regulation of JAG1 8 0.41 6.95 3.5
67 INT76098 Positive_regulation of Positive_regulation of IRF6 16 0.27 6.05 3.35
68 INT62547 Positive_regulation of Gene_expression of Anxa1 5 0.42 4.52 3.27
69 INT48042 Positive_regulation of Anxa1 5 0.50 3.64 3.19
70 INT77615 Positive_regulation of Negative_regulation of Ptgs1 6 0.50 1.55 3.11
71 INT137656 Negative_regulation of Binding of Casp3 4 0.21 0.7 3.09
72 INT134470 Positive_regulation of Map2k1 74 0.49 46.07 3.02
73 INT134798 Gene_expression of ANXA1 15 0.75 13.94 2.99
74 INT181008 Negative_regulation of Localization of IRF6 13 0.14 2.32 2.96
75 INT1653 Positive_regulation of DSP 8 0.49 3.3 2.93
76 INT90402 Positive_regulation of Gene_expression of Ptgs1 13 0.31 4.83 2.88
77 INT139872 Regulation of Notch1 14 0.45 7.69 2.82
78 INT78146 Gene_expression of AKR1C3 24 0.77 5.71 2.77
79 INT88852 Protein_catabolism of Casp3 28 0.65 23.57 2.74
80 INT38872 Negative_regulation of Dsp 10 0.42 3.51 2.73
81 INT33057 Binding of Dsp 9 0.36 4.05 2.66
82 INT27607 Localization of Ptgs1 7 0.59 3.22 2.6
83 INT127176 Transcription of Ptgs2 8 0.58 4.68 2.58
84 INT237700 Regulation of Negative_regulation of IRF6 2 0.11 1.08 2.58
85 INT165726 Positive_regulation of Anxa1 7 0.29 3.16 2.57
86 INT237655 Binding of Sfn 1 0.42 3.62 2.55
87 INT131112 Phosphorylation of Casp3 7 0.63 4.1 2.46
88 INT70197 Negative_regulation of Positive_regulation of Ptgs1 6 0.24 2.61 2.44
89 INT31118 Localization of Casp3 17 0.73 11.55 2.3
90 INT9887 Negative_regulation of Gene_expression of Ptgs1 7 0.42 2.94 2.3
91 INT237653 Gene_expression of Sfn 6 0.59 5.54 2.26
92 INT166838 Positive_regulation of ANXA1 4 0.64 4.88 2.16
93 INT108589 Negative_regulation of Gene_expression of CASP3 13 0.57 10.52 2.14
94 INT50057 Regulation of Notch1 3 0.39 0.87 2.14
95 INT98176 Positive_regulation of Localization of Casp3 7 0.33 6.85 2.12
96 INT155234 Gene_expression of TXNIP 48 0.77 24.4 2.05
97 INT127756 Negative_regulation of Map2k1 10 0.41 6.69 2.04
98 INT101985 Positive_regulation of Positive_regulation of Ptgs1 4 0.15 4.13 1.98
99 INT77805 Regulation of Gene_expression of Ptgs2 6 0.51 2.7 1.92
100 INT140036 Positive_regulation of Gene_expression of Notch1 6 0.61 2 1.86
101 INT52633 Negative_regulation of Notch1 4 0.42 2.99 1.84
102 INT53812 Regulation of Gene_expression of Ptgs1 5 0.38 0.89 1.78
103 INT135444 Regulation of Map2k1 4 0.44 1.15 1.77
104 INT85498 Positive_regulation of Gene_expression of Anxa1 3 0.50 2.12 1.7
105 INT102532 Protein_catabolism of Casp3 24 0.64 16.78 1.64
106 INT172041 Gene_expression of FLG 6 0.65 3.55 1.58
107 INT6830 Positive_regulation of Notch1 20 0.55 7.91 1.57
108 INT31395 Negative_regulation of Lor 7 0.51 1.04 1.57
109 INT25771 Regulation of DSP 8 0.10 3.67 1.55
110 INT117033 Gene_expression of JAG1 13 0.65 11.46 1.52
111 INT42152 Gene_expression of Dsp 7 0.66 4.13 1.52
112 INT163381 Transcription of Notch1 2 0.69 0.41 1.52
113 INT85499 Regulation of Anxa1 1 0.27 1.88 1.52
114 INT2620 Regulation of TGM1 1 0.01 3.27 1.5
115 INT106749 Negative_regulation of Negative_regulation of Casp3 6 0.34 5.12 1.48
116 INT188397 Regulation of Positive_regulation of IRF6 4 0.12 1.34 1.47
117 INT149622 Positive_regulation of Transcription of Ptgs2 3 0.28 2.48 1.46
118 INT140843 Regulation of Phosphorylation of Casp3 1 0.25 0.37 1.44
119 INT104121 Positive_regulation of MAP2K1 8 0.61 4.84 1.41
120 INT2619 Positive_regulation of TGM1 7 0.49 5.97 1.41
121 INT21523 Positive_regulation of Ctnnd1 1 0.27 0.35 1.4
122 INT89209 Negative_regulation of Binding of Ptgs1 6 0.06 2.7 1.39
123 INT175525 Positive_regulation of Phosphorylation of Map2k1 8 0.33 7.02 1.37
124 INT71782 Gene_expression of MAP2K1 7 0.68 3.17 1.37
125 INT171690 Transcription of Casp3 8 0.55 2.62 1.36
126 INT97943 Positive_regulation of Protein_catabolism of Casp3 7 0.28 7.4 1.35
127 INT95367 Negative_regulation of Positive_regulation of IRF6 7 0.21 3.5 1.34
128 INT110784 Protein_catabolism of Notch1 8 0.21 2.32 1.31
129 INT29955 Regulation of Dsp 3 0.54 0.61 1.26
130 INT101026 Positive_regulation of Negative_regulation of Ptgs2 2 0.35 1.01 1.23
131 INT70088 Binding of TGM1 9 0.41 5.3 1.22
132 INT112498 Gene_expression of TGM1 18 0.55 10.76 1.21
133 INT9205 Binding of DSP 12 0.44 9.9 1.21
134 INT110780 Localization of Notch1 2 0.06 0.47 1.19
135 INT150074 Gene_expression of WNT5A 8 0.75 6.3 1.17
136 INT214235 Binding of CDSN 3 0.34 3.5 1.15
137 INT123727 Negative_regulation of Notch1 6 0.21 1.22 1.11
138 INT116406 Negative_regulation of CDSN 2 0.02 0.23 1.08
139 INT102845 Localization of CASP3 7 0.81 2.81 1.06
140 INT101889 Negative_regulation of DSP 3 0.42 1.61 1.05
141 INT71233 Negative_regulation of Anxa1 1 0.07 0.15 1.05
142 INT115481 Gene_expression of CDSN 6 0.10 2.53 1.03
143 INT138287 Gene_expression of Map2k1 69 0.65 46.14 1.02
144 INT228871 Negative_regulation of Gene_expression of Anxa1 2 0.03 1.92 1.01
145 INT122151 Localization of Anxa1 1 0.75 0.53 1
146 INT185929 Regulation of Gene_expression of IRF6 9 0.20 1.66 0.99
147 INT29956 Positive_regulation of Dsp 5 0.41 1.81 0.98
148 INT63284 Transcription of Ptgs1 5 0.66 1.34 0.97
149 INT6833 Binding of Notch1 4 0.36 0.05 0.94
150 INT31117 Binding of Casp3 14 0.23 5.27 0.93
151 INT63037 Regulation of CSTA 10 0.37 13.37 0.92
152 INT131105 Positive_regulation of Negative_regulation of Casp3 3 0.29 3.15 0.84
153 INT149624 Regulation of Transcription of Ptgs2 1 0.16 0.84 0.84
154 INT295239 Negative_regulation of Anxa1 2 0.02 1.6 0.81
155 INT71778 Positive_regulation of Gene_expression of MAP2K1 2 0.36 0.37 0.81
156 INT80498 Gene_expression of DSP 15 0.75 7.06 0.79
157 INT115770 Negative_regulation of Positive_regulation of Ptgs2 4 0.43 0.94 0.79
158 INT89340 Positive_regulation of EREG 5 0.69 4.98 0.77
159 INT181667 Regulation of Regulation of Casp3 1 0.22 1.7 0.77
160 INT211909 Regulation of Positive_regulation of Map2k1 1 0.21 0.47 0.76
161 INT108085 Positive_regulation of Gene_expression of AKR1C3 2 0.53 0.58 0.75
162 INT157776 Localization of TGM1 2 0.39 2.52 0.74
163 INT207285 Positive_regulation of Gene_expression of TXNIP 1 0.69 9.53 0.73
164 INT129490 Negative_regulation of Protein_catabolism of Casp3 4 0.22 3.91 0.71
165 INT127175 Negative_regulation of Transcription of Ptgs2 3 0.47 2.11 0.7
166 INT140037 Positive_regulation of Positive_regulation of Notch1 2 0.22 1.34 0.69
167 INT351454 Regulation of Transcription of Casp3 1 0.02 0.51 0.67
168 INT131976 Positive_regulation of Protein_catabolism of CASP3 4 0.49 3.76 0.64
169 INT23612 Regulation of Negative_regulation of Ptgs1 3 0.19 0.69 0.64
170 INT74781 Regulation of JAG1 6 0.39 2.75 0.63
171 INT148382 Positive_regulation of JAG1 5 0.23 3.88 0.63
172 INT25961 Positive_regulation of Positive_regulation of DSP 1 0.04 0.28 0.63
173 INT6831 Negative_regulation of Binding of Notch1 1 0.27 0 0.6
174 INT150075 Positive_regulation of Gene_expression of WNT5A 2 0.67 2.53 0.59
175 INT151401 Localization of JAG1 4 0.65 1.88 0.58
176 INT242061 Positive_regulation of Negative_regulation of Casp3 3 0.09 1.7 0.58
177 INT184345 Gene_expression of Tsg101 10 0.58 3.56 0.57
178 INT63035 Gene_expression of CSTA 10 0.56 11.56 0.57
179 INT185397 Positive_regulation of Binding of IRF6 3 0.12 0.56 0.57
180 INT166836 Negative_regulation of Positive_regulation of ANXA1 2 0.39 1.15 0.57
181 INT122149 Binding of Anxa1 1 0.36 0.22 0.57
182 INT116925 Binding of AKR1C3 2 0.36 0.75 0.56
183 INT37750 Localization of ANXA1 2 0.74 1.72 0.56
184 INT110782 Negative_regulation of Localization of Notch1 1 0.03 0.33 0.56
185 INT181673 Negative_regulation of Transcription of Casp3 3 0.34 0.61 0.55
186 INT115772 Positive_regulation of Localization of Ptgs2 1 0.46 0.5 0.55
187 INT110785 Positive_regulation of Protein_catabolism of Notch1 1 0.05 0.33 0.55
188 INT115771 Positive_regulation of Positive_regulation of Ptgs2 1 0.46 0.5 0.54
189 INT104120 Positive_regulation of Positive_regulation of MAP2K1 1 0.49 0 0.54
190 INT37749 Positive_regulation of Localization of ANXA1 1 0.01 0.67 0.53
191 INT31396 Positive_regulation of Lor 3 0.41 0.26 0.52
192 INT206876 Positive_regulation of Gene_expression of ANXA1 3 0.39 1.68 0.51
193 INT166837 Binding of ANXA1 2 0.34 0.85 0.51
194 INT142835 Regulation of Localization of Ptgs2 2 0.25 0.26 0.5
195 INT97796 Regulation of Localization of IRF6 2 0.20 0.32 0.5
196 INT237651 Negative_regulation of Sfn 3 0.51 1.7 0.49
197 INT236915 Binding of Map2k1 2 0.15 1.51 0.49
198 INT216998 Regulation of Binding of IRF6 2 0.05 0.06 0.48
199 INT130391 Positive_regulation of AKR1C3 4 0.50 1.7 0.47
200 INT237703 Phosphorylation of IRF6 2 0.05 0.91 0.47
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