GO:0030219

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Name megakaryocyte differentiation
Categary Process
Go Slim No
Go Link GO:0030219
Unique Molecular Interactions 134
Total Molecular Interactions 223
Total Single Events 703
Pain Genes Associated 9

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for megakaryocyte differentiation. They are ordered first by their pain relevance and then by number of times they were reported for megakaryocyte differentiation. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT200322 Binding of Rest and Sp3 1 0.39 2.93 3.98
2 INT157540 Binding of SP1 and YY1 1 0.41 2.55 1.42
3 INT134970 Positive_regulation of Binding of OPRK1 and SP1 1 0.00 0 1.05
4 INT134969 Binding of OPRK1 and SP1 1 0.00 0 1.04
5 INT200323 Binding of Oprm1 and Sp3 1 0.39 0 0.99
6 INT77254 Binding of gr and Sp1 1 0.04 0.4 0.9
7 INT103611 Mdk Negative_regulation of Phosphorylation of Sp1 1 0.01 0.28 0.88
8 INT157539 Binding of SP1 and Regulation of Gene_expression of OPRM1 1 0.36 1.2 0.72
9 INT98956 Positive_regulation of Binding of NR5A2 and SP1 1 0.00 0 0.7
10 INT98951 Positive_regulation of Binding of NR5A2 and SP3 1 0.00 0 0.7
11 INT207542 Sp1 Regulation of Oprm1 1 0.15 0.06 0.7
12 INT98957 Binding of NR5A2 and SP3 1 0.00 0 0.7
13 INT98958 Binding of NR5A2 and SP1 1 0.00 0 0.7
14 INT207547 Sp1 Regulation of Qsox1 1 0.05 0.06 0.67
15 INT123416 Gene_expression of Sp1 Positive_regulation of Oprm1 1 0.60 0 0.63
16 INT98955 Positive_regulation of Binding of SP3 and CFHR4 1 0.00 0 0.62
17 INT98953 Positive_regulation of Binding of SP1 and CFHR4 1 0.00 0 0.62
18 INT98954 Binding of SP1 and CFHR4 1 0.00 0 0.61
19 INT98952 Binding of SP3 and CFHR4 1 0.00 0 0.61
20 INT200348 Sp3 Negative_regulation of Gene_expression of Oprm1 1 0.48 0.4 0.55
21 INT172137 IL11 Negative_regulation of Gene_expression of TNF 1 0.09 0.73 0.47
22 INT89332 Binding of SP1 and SP3 1 0.30 0.76 0.39
23 INT200313 Sp3 Regulation of Oprm1 1 0.10 0.07 0.38
24 INT200301 Sp3 Regulation of Rorb 1 0.00 0.07 0.38
25 INT167558 Gene_expression of Sp1 Positive_regulation of Oprm1 1 0.03 0.07 0.36
26 INT167551 Binding of MECP2 and SP3 1 0.01 0.06 0.35
27 INT200333 Binding of Rest and Sp1 1 0.24 0.07 0.35
28 INT200316 Sp1 Regulation of Gene_expression of Rest 1 0.31 0 0.35
29 INT253576 Binding of Lpl and Sp3 1 0.22 0.85 0.32
30 INT200351 Sp1 Positive_regulation of Gene_expression of Rest 1 0.34 0.07 0.3
31 INT96788 Binding of SP3 and NR2F2 1 0.24 0.27 0.27
32 INT96789 Binding of SP1 and NR2F2 1 0.24 0.27 0.27
33 INT96787 SP1 Positive_regulation of GDF15 1 0.08 0.27 0.27
34 INT96790 SP3 Positive_regulation of GDF15 1 0.20 0.26 0.27
35 INT125515 SP1 Regulation of GDF15 1 0.14 0.47 0.26
36 INT169837 Sp1 Positive_regulation of Gene_expression of Kcnq3 1 0.04 0.08 0.26
37 INT126886 Protein_catabolism of SP1 Negative_regulation of Gene_expression of VEGFA 1 0.03 0.49 0.26
38 INT169836 Sp1 Positive_regulation of Gene_expression of Kcnq2 1 0.05 0.08 0.26
39 INT118418 Gata1 Positive_regulation of Transcription of Tac2 1 0.61 0.77 0.25
40 INT260739 Mapk14 Regulation of Positive_regulation of Sp1 1 0.01 1.06 0.25
41 INT118419 Binding of Gata1 and Tac2 1 0.31 0.7 0.24
42 INT200309 Positive_regulation of Binding of Rest and Sp3 1 0.41 0.88 0.24
43 INT294290 PROK1 Positive_regulation of Gene_expression of IL11 1 0.59 0.46 0.23
44 INT253568 Negative_regulation of Binding of Lpl and Sp3 1 0.19 0.37 0.22
45 INT189196 RASGRP1 Positive_regulation of SP1 1 0.05 0.63 0.21
46 INT136462 Negative_regulation of Ptgs1 Negative_regulation of Gene_expression of Sp1 1 0.01 0.65 0.19
47 INT294292 PROK1 Regulation of IL11 1 0.53 0.42 0.17
48 INT294309 PROK1 Regulation of Gene_expression of IL11 1 0.53 0.25 0.15
49 INT253564 Binding of Lpl and Sp1 1 0.13 0.9 0.14
50 INT200328 Sp3 Positive_regulation of Gene_expression of Oprm1 1 0.38 0 0.13
51 INT200315 Binding of Sp1 and Sp3 1 0.29 0 0.12
52 INT68802 Sp1 Regulation of Gene_expression of Pebp1 1 0.24 0 0.12
53 INT253572 Binding of Csnk2a2 and Sp1 1 0.17 0 0.11
54 INT293411 IL8 Regulation of IL11 1 0.03 1.17 0.1
55 INT200320 Binding of Sp3 and Negative_regulation of Gene_expression of Oprm1 1 0.35 0.4 0.1
56 INT210992 Binding of KCNMA1 and SP3 1 0.00 0.17 0.1
57 INT210989 Binding of FSCN1 and SP3 1 0.00 0.17 0.1
58 INT293417 HRAS Regulation of IL11 1 0.00 1.17 0.1
59 INT171163 Creb1 Regulation of Sp1 1 0.03 0.62 0.1
60 INT194822 Negative_regulation of MAPK1 Negative_regulation of Binding of Sp1 1 0.04 0.05 0.1
61 INT210988 Binding of SP3 and PKDREJ 1 0.01 0.17 0.1
62 INT210994 Binding of SEA and SP3 1 0.00 0.17 0.1
63 INT253571 Positive_regulation of Binding of Lpl and Sp1 1 0.17 0.42 0.09
64 INT294295 PROK1 Positive_regulation of IL11 1 0.40 0.15 0.09
65 INT253579 Negative_regulation of Binding of Lpl and Sp1 1 0.15 0.42 0.09
66 INT294289 IL11 Positive_regulation of Gene_expression of NPEPPS 1 0.01 0.06 0.09
67 INT313509 Binding of ALOX5 and SP1 1 0.07 1.51 0.08
68 INT294302 PROK1 Positive_regulation of Localization of IL11 1 0.40 0.36 0.08
69 INT294308 PROKR1 Regulation of Gene_expression of IL11 1 0.34 0 0.08
70 INT245118 RBM45 Negative_regulation of CDKN2B 1 0.01 1.41 0.08
71 INT294310 PTGER2 Positive_regulation of Gene_expression of IL11 1 0.06 0.12 0.08
72 INT245119 Negative_regulation of RBM45 Negative_regulation of CDKN2B 1 0.01 1.43 0.08
73 INT253570 Binding of Csnk2a2 and Sp3 1 0.16 0.2 0.07
74 INT253577 Csnk2a2 Positive_regulation of Phosphorylation of Sp1 1 0.17 0.37 0.06
75 INT118417 Gata1 Regulation of Gene_expression of Serpinb9g 1 0.17 0.12 0.06
76 INT294291 PROK1 Regulation of Localization of IL11 1 0.53 0 0.05
77 INT294311 Gene_expression of RCAN1 Positive_regulation of IL11 1 0.39 0 0.04
78 INT295718 Binding of PTGER2 and Positive_regulation of Positive_regulation of SP1 1 0.02 0.58 0.04
79 INT253574 Sp3 Positive_regulation of Lpl 1 0.22 0 0.03
80 INT294303 PTGER2 Positive_regulation of Localization of IL11 1 0.04 0.08 0.03
81 INT294301 PTGER2 Positive_regulation of IL11 1 0.04 0.08 0.03
82 INT314052 Binding of VEGFA and Sp1 1 0.02 1.25 0.03
83 INT253566 Sp1 Positive_regulation of Lpl 1 0.18 0 0.03
84 INT215686 Cdkn2b Negative_regulation of Cdkn1c 1 0.01 0 0
85 INT294312 PROKR1 Positive_regulation of Gene_expression of IL11 1 0.38 0 0
86 INT245820 Binding of Sp1 and Tfap2a 1 0.03 0.64 0
87 INT215700 Binding of Cdkn2b and Cdk6 1 0.02 0 0
88 INT294307 Gene_expression of RCAN1 Negative_regulation of Gene_expression of IL11 1 0.36 0.09 0
89 INT294306 Positive_regulation of PROK1 Positive_regulation of Transcription of IL11 1 0.40 0.08 0
90 INT294300 PROK1 Positive_regulation of Positive_regulation of IL11 1 0.40 0.15 0
91 INT215344 Binding of Sp1 and Vdac1 1 0.02 0.1 0
92 INT294316 IL6ST Positive_regulation of Gene_expression of IL11 1 0.22 0 0
93 INT304168 Binding of Gata1 and Sfpi1 1 0.08 0.07 0
94 INT284915 Binding of CDKN2B and HIST2H3C 1 0.05 0.43 0
95 INT294314 Binding of IL11 and NFATC1 1 0.06 0 0
96 INT293413 GOPC Regulation of Localization of IL11 1 0.03 0.6 0
97 INT215688 Cdkn2b Negative_regulation of Kras 1 0.00 0 0
98 INT292143 Binding of HIVEP1 and SP1 1 0.01 0.33 0
99 INT253567 Binding of Pik3r1 and Sp3 1 0.11 0.06 0
100 INT292139 SP3 Positive_regulation of Transcription of HIVEP1 1 0.02 0.42 0
101 INT215694 Cdkn2b Negative_regulation of Cdkn1b 1 0.01 0 0
102 INT245829 Binding of VEGFA and Sp1 1 0.04 0.65 0
103 INT292149 Binding of GTF2B and SP1 1 0.03 0.4 0
104 INT294313 Gene_expression of CABIN1 Positive_regulation of IL11 1 0.03 0.06 0
105 INT294296 Binding of IL11 and PROK1 1 0.32 0.07 0
106 INT215341 Binding of Htt and Sp1 1 0.03 0.25 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for megakaryocyte differentiation. They are ordered first by their pain relevance and then by number of times they were reported in megakaryocyte differentiation. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT41558 Localization of Sp1 9 0.48 0.56 14.9
2 INT24082 Negative_regulation of Sp1 13 0.40 1.19 13.11
3 INT121752 Gene_expression of IL11 54 0.62 18.05 7.16
4 INT48555 Binding of SP1 30 0.46 11.38 6.53
5 INT41604 Negative_regulation of Localization of Sp1 2 0.30 0.32 5.86
6 INT198736 Binding of Sp3 23 0.40 4.77 4.42
7 INT123411 Gene_expression of Sp1 15 0.69 4.2 3.79
8 INT41559 Positive_regulation of Sp1 7 0.45 2.65 3.24
9 INT123409 Binding of Sp1 20 0.39 3.18 3.15
10 INT103607 Binding of Sp1 7 0.42 1.26 2.92
11 INT93213 Phosphorylation of Sp1 5 0.67 0.93 2.84
12 INT89336 Binding of SP3 6 0.47 1.75 2.63
13 INT24902 Gene_expression of SP1 17 0.71 8.11 2.58
14 INT23998 Positive_regulation of Sp1 4 0.40 0.51 2.56
15 INT172179 Positive_regulation of Gene_expression of IL11 7 0.55 4.29 2.43
16 INT103609 Transcription of Sp1 1 0.11 0.97 2.42
17 INT103608 Negative_regulation of Binding of Sp1 4 0.35 0.69 2.1
18 INT41495 Regulation of Sp1 7 0.42 2.96 2.05
19 INT41557 Gene_expression of Sp1 5 0.68 1.17 2.04
20 INT24906 Negative_regulation of SP1 8 0.40 4.48 1.77
21 INT118412 Gene_expression of Gata1 5 0.62 0.83 1.6
22 INT41605 Positive_regulation of Localization of Sp1 1 0.05 0 1.58
23 INT118413 Positive_regulation of Gene_expression of Gata1 3 0.40 0.68 1.56
24 INT136459 Gene_expression of Sp3 6 0.64 1.97 1.47
25 INT123414 Transcription of Sp1 5 0.48 2.2 1.38
26 INT94692 Positive_regulation of Gene_expression of Sp1 3 0.17 0.39 1.28
27 INT106423 Binding of IL11 6 0.37 2.16 1.27
28 INT24000 Regulation of Sp1 2 0.22 1.25 1.27
29 INT171041 Positive_regulation of IL11 5 0.55 2.49 1.22
30 INT48554 Positive_regulation of SP1 12 0.49 3.64 1.2
31 INT70673 Regulation of IL11 5 0.45 2.89 1.2
32 INT93216 Negative_regulation of Phosphorylation of Sp1 2 0.14 0.4 1.13
33 INT123408 Positive_regulation of Gene_expression of Sp1 2 0.62 0.9 0.96
34 INT123407 Negative_regulation of Binding of Sp1 6 0.47 0.72 0.93
35 INT136458 Negative_regulation of Sp3 3 0.39 1.53 0.93
36 INT200272 Localization of Sp1 3 0.57 0.06 0.93
37 INT123410 Negative_regulation of Gene_expression of Sp1 3 0.38 1.01 0.82
38 INT171017 Localization of IL11 9 0.64 4.83 0.76
39 INT101411 Negative_regulation of IL11 4 0.43 1.16 0.75
40 INT144995 Positive_regulation of Gata1 1 0.37 0.14 0.71
41 INT289467 Transcription of IL11 6 0.57 1.5 0.67
42 INT98967 Localization of SP1 2 0.60 0.15 0.66
43 INT24905 Negative_regulation of Gene_expression of SP1 4 0.39 2.05 0.65
44 INT126899 Regulation of SP1 5 0.43 2.53 0.57
45 INT100191 Gene_expression of Cdkn2b 1 0.65 0.06 0.51
46 INT89334 Negative_regulation of Binding of SP1 2 0.47 1.05 0.5
47 INT172174 Negative_regulation of Binding of IL11 1 0.08 0.63 0.48
48 INT172175 Positive_regulation of Negative_regulation of IL11 1 0.10 0.63 0.48
49 INT200264 Localization of Sp3 1 0.62 0 0.47
50 INT253558 Negative_regulation of Binding of Sp3 1 0.39 1.09 0.46
51 INT126896 Positive_regulation of Protein_catabolism of SP1 1 0.13 0.99 0.44
52 INT98969 Regulation of Binding of SP3 1 0.26 0 0.41
53 INT89333 Negative_regulation of SP3 1 0.38 0.77 0.39
54 INT89335 Negative_regulation of Binding of SP3 1 0.38 0.77 0.39
55 INT126895 Protein_catabolism of SP1 3 0.96 3.59 0.38
56 INT98963 Positive_regulation of Binding of SP1 1 0.43 0 0.37
57 INT98960 Positive_regulation of Binding of SP3 1 0.67 0 0.37
58 INT166959 Positive_regulation of Positive_regulation of SP1 3 0.46 2.23 0.35
59 INT200265 Regulation of Sp3 2 0.37 0.25 0.34
60 INT136460 Negative_regulation of Sp1 2 0.30 0.99 0.3
61 INT200276 Positive_regulation of Sp3 1 0.42 0.17 0.28
62 INT93215 Positive_regulation of Phosphorylation of Sp1 1 0.11 0.09 0.27
63 INT123541 Regulation of Gene_expression of Cdkn2b 1 0.26 0.06 0.26
64 INT253556 Phosphorylation of Sp1 6 0.44 2.93 0.24
65 INT200251 Phosphorylation of Sp3 2 0.67 0.42 0.24
66 INT136457 Negative_regulation of Negative_regulation of Sp1 1 0.30 0.65 0.2
67 INT253542 Positive_regulation of Phosphorylation of Sp1 1 0.27 1.16 0.2
68 INT136452 Negative_regulation of Negative_regulation of Sp3 1 0.28 0.65 0.2
69 INT294334 Regulation of Positive_regulation of IL11 1 0.36 0.3 0.17
70 INT136454 Positive_regulation of Gene_expression of Sp3 1 0.33 0.44 0.16
71 INT178673 Positive_regulation of Gene_expression of SP1 1 0.08 0.14 0.16
72 INT294354 Negative_regulation of Gene_expression of IL11 1 0.46 0 0.15
73 INT220570 Transcription of Gata1 2 0.05 0.91 0.14
74 INT200261 Positive_regulation of Transcription of Sp3 1 0.42 0 0.13
75 INT200280 Transcription of Sp3 1 0.57 0 0.13
76 INT294341 Positive_regulation of Positive_regulation of IL11 1 0.55 0 0.13
77 INT343560 Regulation of Transcription of IL11 1 0.05 0 0.11
78 INT200268 Positive_regulation of Binding of Sp3 2 0.39 0.8 0.1
79 INT294338 Regulation of Regulation of IL11 1 0.21 0.2 0.1
80 INT173632 Transcription of SP1 7 0.41 1.42 0.09
81 INT322523 Regulation of Transcription of SP1 1 0.11 0.15 0.09
82 INT253546 Positive_regulation of Phosphorylation of Sp3 1 0.29 0.42 0.09
83 INT211005 Gene_expression of SP3 1 0.03 0.58 0.09
84 INT245123 Gene_expression of CDKN2B 6 0.68 3.62 0.07
85 INT184989 Positive_regulation of CDKN2B 3 0.47 2.77 0.07
86 INT185030 Binding of CDKN2B 3 0.35 2.6 0.07
87 INT253554 Regulation of Negative_regulation of Sp3 1 0.30 0 0.05
88 INT170453 Protein_catabolism of IL11 1 0.88 0.21 0.05
89 INT294340 Negative_regulation of Localization of IL11 1 0.34 0 0.04
90 INT294356 Regulation of Gene_expression of IL11 1 0.49 0.33 0.04
91 INT194474 Positive_regulation of Binding of Sp1 1 0.03 0.6 0.04
92 INT194476 Regulation of Binding of Sp1 1 0.02 0.6 0.04
93 INT293420 Positive_regulation of Localization of IL11 4 0.37 1.55 0.03
94 INT173623 Positive_regulation of Transcription of SP1 3 0.30 0.95 0
95 INT284972 Negative_regulation of CDKN2B 3 0.44 1.13 0
96 INT284937 Negative_regulation of Positive_regulation of CDKN2B 1 0.37 0.31 0
97 INT294327 Negative_regulation of Positive_regulation of IL11 1 0.34 0 0
98 INT173637 Negative_regulation of Positive_regulation of SP1 1 0.05 0.27 0
99 INT136453 Protein_catabolism of Sp1 1 0.70 0.15 0
100 INT292209 Regulation of SP3 1 0.17 0.34 0
101 INT292205 Phosphorylation of SP1 1 0.21 0.07 0
102 INT136451 Protein_catabolism of Sp3 1 0.66 0.15 0
103 INT136461 Positive_regulation of Protein_catabolism of Sp3 1 0.46 0.15 0
104 INT294333 Negative_regulation of Transcription of IL11 1 0.46 0 0
105 INT253555 Regulation of Binding of Sp3 1 0.30 0.06 0
106 INT284941 Transcription of CDKN2B 1 0.63 1.59 0
107 INT284970 Positive_regulation of Gene_expression of CDKN2B 1 0.61 0.55 0
108 INT293421 Regulation of Localization of IL11 1 0.08 0.6 0
109 INT147085 Binding of Cdkn2b 1 0.10 0.07 0
110 INT284988 Positive_regulation of Transcription of CDKN2B 1 0.44 1.1 0
111 INT262679 Phosphorylation of Gata1 1 0.18 0.55 0
112 INT136455 Positive_regulation of Protein_catabolism of Sp1 1 0.49 0.15 0
113 INT262696 Binding of Gata1 1 0.08 0.56 0
114 INT294343 Positive_regulation of Transcription of IL11 1 0.37 0.13 0
115 INT78107 Regulation of Positive_regulation of SP1 1 0.32 0.1 0
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