GO:0030235

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Name nitric-oxide synthase regulator activity
Categary Function
Go Slim No
Go Link GO:0030235
Unique Molecular Interactions 857
Total Molecular Interactions 1203
Total Single Events 9333
Pain Genes Associated 12

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for nitric-oxide synthase regulator activity. They are ordered first by their pain relevance and then by number of times they were reported for nitric-oxide synthase regulator activity. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT132225 Negative_regulation of Binding of Akt1 and Sh2d6 1 0.10 3.92 7.2
2 INT169218 Binding of EGFR and Coc 1 0.06 2.8 5.85
3 INT132231 Negative_regulation of Binding of Akt1 and Pik3cg 1 0.34 1.96 3.6
4 INT317522 Akt1 Positive_regulation of Phosphorylation of Nos1 1 0.43 0.4 3.13
5 INT168758 Hist1h1t Positive_regulation of Phosphorylation of Akt1 2 0.02 0.44 2.79
6 INT317551 Binding of Akt1 and Oprm1 1 0.19 0.21 2.74
7 INT356289 Binding of Egfr and Egf 1 0.13 3.02 2.52
8 INT121726 Ngf Positive_regulation of Phosphorylation of Akt1 1 0.37 1.4 2.34
9 INT114432 Oprl1 Positive_regulation of Akt1 1 0.18 0.08 2.2
10 INT169346 Nxn Negative_regulation of Dynll1 1 0.06 1.22 1.87
11 INT132229 Binding of Akt1 and Sh2d6 1 0.09 0.98 1.8
12 INT169464 Akt1 Positive_regulation of Egfr 1 0.28 1.63 1.7
13 INT322412 PPBP Negative_regulation of Phosphorylation of Akt1 1 0.01 0 1.65
14 INT214372 Ptprq Positive_regulation of Akt1 1 0.04 0.88 1.43
15 INT214369 Pik3cb Positive_regulation of Akt1 1 0.56 0.87 1.41
16 INT222182 Binding of ESR1 and HLA-DRB2 1 0.00 3.1 1.35
17 INT169297 TRPV1 Positive_regulation of EGFR 1 0.64 0.37 1.3
18 INT169289 CNR1 Positive_regulation of EGFR 1 0.62 0.36 1.28
19 INT317548 Positive_regulation of Akt1 Positive_regulation of Prkca 1 0.15 0 1.11
20 INT317516 Binding of Oprm1 and Negative_regulation of Positive_regulation of Akt1 1 0.17 0.1 1.11
21 INT323175 PRKCA Positive_regulation of Akt1 1 0.02 0 1.1
22 INT108547 AKT1 Regulation of MAPKAPK5 1 0.04 1.2 1.08
23 INT151218 Negative_regulation of SIGMAR1 Negative_regulation of Positive_regulation of Akt1 1 0.00 0.26 1.03
24 INT317554 Akt1 Regulation of Negative_regulation of Oprm1 1 0.21 0.07 1
25 INT278292 Binding of CRP and ESR1 6 0.09 10.92 0.96
26 INT317567 Binding of Akt1 and Nos1 1 0.22 0 0.96
27 INT137923 VEGFA Positive_regulation of Phosphorylation of Akt1 1 0.05 0 0.93
28 INT114883 Akt1 Regulation of Pik3r1 2 0.16 0.65 0.92
29 INT161455 Mmp7 Positive_regulation of Egfr 1 0.03 0.19 0.92
30 INT317541 Oprd1 Negative_regulation of Akt1 1 0.06 0 0.91
31 INT118288 EGF Positive_regulation of Phosphorylation of EGFR 9 0.54 3.85 0.9
32 INT249012 Binding of Akt1 and Gabrg1 1 0.01 0 0.9
33 INT132226 Binding of Akt1 and Pik3cg 1 0.30 0.49 0.9
34 INT134454 EGF Positive_regulation of EGFR 3 0.56 1.32 0.88
35 INT134453 Negative_regulation of EGF Positive_regulation of EGFR 1 0.35 0.35 0.88
36 INT199109 Binding of Akt1 and Arhgdia 1 0.02 2.73 0.87
37 INT116106 VEGFA Positive_regulation of AKT1 1 0.12 0.3 0.83
38 INT317556 Phosphorylation of Gopc Positive_regulation of Akt1 1 0.10 0.08 0.82
39 INT117341 ADAM17 Positive_regulation of EGFR 1 0.16 3.56 0.82
40 INT317514 Akt1 Regulation of Localization of Oprm1 1 0.21 0.07 0.82
41 INT228255 Binding of Akt1 and Pten 2 0.43 1.78 0.8
42 INT322397 Egfr Positive_regulation of Adarb1 1 0.00 0.08 0.8
43 INT258798 Binding of NR3C1 and HSP90AA1 1 0.01 1.09 0.78
44 INT111888 Akt1 Regulation of Regulation of Oprm1 1 0.04 0 0.77
45 INT134043 Jak2 Positive_regulation of Akt1 1 0.31 0.22 0.76
46 INT335592 Ltp Positive_regulation of Positive_regulation of Akt1 1 0.01 0.19 0.74
47 INT106527 Akt1 Positive_regulation of Jun 1 0.05 0.53 0.74
48 INT276213 Pten Regulation of Phosphorylation of Akt1 1 0.51 0.61 0.72
49 INT220738 EGF Regulation of Gene_expression of EGFR 1 0.09 0.6 0.67
50 INT298728 Akt1 Positive_regulation of Rela 1 0.01 1.03 0.67
51 INT169213 Binding of EGFR and CARTPT 1 0.00 0.22 0.67
52 INT289357 Ngfr Positive_regulation of Akt1 1 0.03 3.1 0.66
53 INT308668 Akt1 Positive_regulation of Nos3 3 0.05 4.61 0.65
54 INT296793 Akt1 Positive_regulation of Gene_expression of Bax 1 0.11 0.75 0.65
55 INT296791 Positive_regulation of Akt1 Positive_regulation of Gene_expression of Bax 1 0.11 0.8 0.65
56 INT169293 PTPLA Positive_regulation of AKT1 1 0.10 0.15 0.64
57 INT134047 Fitm1 Positive_regulation of Phosphorylation of Akt1 1 0.05 0.21 0.63
58 INT134044 Positive_regulation of Fitm1 Positive_regulation of Phosphorylation of Akt1 1 0.05 0.21 0.63
59 INT278695 MTX1 Negative_regulation of Phosphorylation of AKT1 1 0.04 0.81 0.62
60 INT200808 Binding of Akt1 and Insrr 2 0.00 0.98 0.61
61 INT165844 Binding of ATF4 and HSP90AB1 1 0.15 0.34 0.61
62 INT282286 Akt1 Positive_regulation of Pak1 1 0.15 0.24 0.61
63 INT139901 Ins1 Positive_regulation of Akt1 9 0.31 4.58 0.6
64 INT248994 Binding of Akt1 and Ptar1 1 0.00 0 0.58
65 INT169286 CNR1 Positive_regulation of Phosphorylation of EGFR 1 0.45 0.18 0.57
66 INT341594 Binding of ESR1 and HLA-B 1 0.01 0.72 0.57
67 INT323176 PRKCA Positive_regulation of Phosphorylation of Akt1 1 0.02 0 0.56
68 INT302832 Tnfsf10 Positive_regulation of Akt1 1 0.04 1.63 0.56
69 INT201944 CXCL10 Positive_regulation of Phosphorylation of AKT1 1 0.09 0.79 0.55
70 INT114064 Agtr2 Positive_regulation of Phosphorylation of Akt1 1 0.24 0.41 0.54
71 INT282284 Cpox Positive_regulation of Akt1 1 0.02 0.47 0.54
72 INT282282 Ptger2 Positive_regulation of Akt1 1 0.03 0.47 0.54
73 INT162994 Binding of Akt1 and Trib3 1 0.04 0.09 0.54
74 INT127320 Gpx3 Regulation of Akt1 2 0.00 3.11 0.53
75 INT317523 Oprm1 Positive_regulation of Gene_expression of Akt1 1 0.32 0.05 0.53
76 INT109307 Pik3r1 Positive_regulation of Phosphorylation of Akt1 1 0.29 0.4 0.53
77 INT317574 Oprm1 Positive_regulation of Akt1 1 0.22 0.05 0.52
78 INT97952 Negative_regulation of NRP2 Negative_regulation of Positive_regulation of AKT1 1 0.03 0.72 0.51
79 INT151221 Negative_regulation of SIGMAR1 Negative_regulation of Akt1 1 0.00 0.13 0.51
80 INT291556 Binding of ESR1 and Sec22b 2 0.00 0.86 0.5
81 INT97951 ST3GAL3 Positive_regulation of AKT1 1 0.04 0.7 0.5
82 INT102844 Pdc Regulation of Akt1 1 0.03 0 0.49
83 INT220741 Binding of EGFR and SOAT1 1 0.02 0.37 0.49
84 INT134042 Jak2 Regulation of Akt1 1 0.18 0.13 0.47
85 INT309126 Edc4 Positive_regulation of Akt1 1 0.02 0.99 0.47
86 INT309144 Dlat Positive_regulation of Akt1 1 0.03 0.99 0.47
87 INT276207 Binding of Akt1 and Myo1f 1 0.11 0.05 0.47
88 INT162932 TXNRD1 Negative_regulation of Phosphorylation of AKT1 1 0.14 1.01 0.47
89 INT114065 Akt1 Regulation of Gene_expression of Insr 1 0.13 0.28 0.46
90 INT276218 Binding of Akt1 and Pten 1 0.26 0.08 0.46
91 INT162929 NQO1 Negative_regulation of Phosphorylation of AKT1 1 0.41 1 0.46
92 INT139900 Kcne2 Positive_regulation of Akt1 1 0.06 2.95 0.44
93 INT160047 PTEN Regulation of Gene_expression of AKT1 1 0.33 0.6 0.42
94 INT348785 Ins1 Positive_regulation of Phosphorylation of Akt1 1 0.17 3.5 0.42
95 INT322396 Hist1h1t Positive_regulation of Akt1 1 0.01 0 0.42
96 INT160048 INPPL1 Regulation of Gene_expression of AKT1 1 0.28 0.6 0.42
97 INT322395 Akt1 Regulation of Pik3cb 1 0.08 0 0.42
98 INT121851 AKT1 Regulation of ROS1 1 0.16 0.52 0.41
99 INT122749 Cyp3a23/3a1 Positive_regulation of Phosphorylation of Akt1 1 0.07 0.24 0.41
100 INT121848 AKT1 Regulation of CASP8 1 0.18 0.52 0.41
101 INT121854 AKT1 Regulation of BID 1 0.17 0.52 0.41
102 INT276216 Binding of Akt1 and Ins1 2 0.03 2.61 0.4
103 INT108197 AKT1 Regulation of JUN 1 0.29 0.25 0.4
104 INT231842 Pcdh8 Positive_regulation of Akt1 1 0.00 1.59 0.4
105 INT121853 Gene_expression of ROS1 Negative_regulation of AKT1 1 0.25 0.49 0.4
106 INT322409 Positive_regulation of OPRM1 Positive_regulation of Phosphorylation of Akt1 1 0.04 0 0.4
107 INT166155 Ccr9 Positive_regulation of Akt1 1 0.58 2.14 0.39
108 INT199974 ESR1 Negative_regulation of Gene_expression of ITGB3BP 1 0.05 0.47 0.38
109 INT272751 EGFR Regulation of Negative_regulation of Prkca 1 0.01 0 0.38
110 INT146611 Ins1 Positive_regulation of Phosphorylation of Akt1 9 0.23 4.34 0.37
111 INT89386 INS Positive_regulation of Phosphorylation of AKT1 3 0.43 1.48 0.36
112 INT299288 AKT1 Positive_regulation of RPTOR 1 0.34 0.05 0.36
113 INT148243 Binding of Akt1 and Kit 1 0.03 0.44 0.35
114 INT122758 Positive_regulation of Helt Positive_regulation of Akt1 1 0.00 0.2 0.35
115 INT288208 Binding of Mapk14 and Positive_regulation of Akt1 1 0.01 0.42 0.35
116 INT291555 Binding of ESR1 and Dlat 1 0.01 0.6 0.35
117 INT176135 AKT1 Regulation of Localization of CYCS 1 0.43 2.16 0.35
118 INT122756 Helt Positive_regulation of Akt1 1 0.00 0.2 0.35
119 INT309118 Dlat Positive_regulation of Positive_regulation of Akt1 1 0.03 0.32 0.34
120 INT249019 Gabrg1 Positive_regulation of Akt1 1 0.02 0 0.34
121 INT196820 Negative_regulation of Ppp1cc Positive_regulation of Akt1 1 0.00 0 0.34
122 INT89381 INS Positive_regulation of AKT1 6 0.43 3.06 0.33
123 INT291554 Binding of ESR1 and St8sia2 1 0.01 0.49 0.33
124 INT214377 Akt1 Regulation of Amph 1 0.15 0 0.33
125 INT188521 Binding of Hsp90aa1 and Ptges3 1 0.02 0.61 0.33
126 INT165580 Binding of Akt1 and Grin2b 1 0.02 0.2 0.32
127 INT337410 AKT3 Negative_regulation of AKT1 1 0.09 0.49 0.32
128 INT337414 AKT2 Negative_regulation of AKT1 1 0.10 0.5 0.32
129 INT255740 Pik3r1 Positive_regulation of Akt1 5 0.24 2.42 0.31
130 INT303063 Akt1 Negative_regulation of Gene_expression of Syn1 1 0.09 0.45 0.31
131 INT165921 Tlr4 Positive_regulation of Akt1 1 0.16 0.75 0.31
132 INT165920 Negative_regulation of Tlr4 Positive_regulation of Akt1 1 0.13 0.75 0.31
133 INT299307 AKT1 Positive_regulation of Positive_regulation of AKT1S1 1 0.10 0 0.3
134 INT299289 AKT1 Positive_regulation of Positive_regulation of TSC2 1 0.17 0 0.3
135 INT222301 Binding of ERBB2 and ESR1 5 0.36 5.07 0.29
136 INT122575 Akt1 Positive_regulation of Phosphorylation of Nos3 4 0.37 3.89 0.29
137 INT185799 Binding of EGFR and SPP1 1 0.19 0.64 0.29
138 INT291202 Positive_regulation of INS Positive_regulation of AKT1 1 0.01 0.76 0.29
139 INT166093 Negative_regulation of ROS1 Negative_regulation of Positive_regulation of EGFR 1 0.12 0.33 0.28
140 INT132367 Lgals1 Positive_regulation of Akt1 1 0.22 0.13 0.28
141 INT317533 Akt1 Positive_regulation of Nos1 1 0.43 0 0.28
142 INT185092 CRP Positive_regulation of ESR1 1 0.06 2.83 0.28
143 INT199978 ESR1 Regulation of ITGB3BP 1 0.03 0.39 0.28
144 INT166094 Negative_regulation of CSK Negative_regulation of Positive_regulation of EGFR 1 0.02 0.33 0.28
145 INT71904 Binding of ESR1 and PGR 6 0.34 3.79 0.27
146 INT323152 Binding of DBT and ESR1 2 0.02 1.29 0.27
147 INT149322 Amph Positive_regulation of Akt1 1 0.39 0 0.27
148 INT346195 AMELX Negative_regulation of ESR1 1 0.02 0.36 0.26
149 INT223930 Binding of Akt1 and Pik3cb 1 0.07 0.35 0.26
150 INT223929 Negative_regulation of Binding of Akt1 and Pik3cb 1 0.08 0.36 0.26
151 INT303082 Akt1 Negative_regulation of Gene_expression of Mafk 1 0.20 0.37 0.26
152 INT308661 Akt1 Positive_regulation of Chuk 1 0.02 0.6 0.25
153 INT314047 THL Negative_regulation of Phosphorylation of Akt1 1 0.14 0.71 0.25
154 INT186783 Binding of ESR1 and NRIP1 1 0.31 0.79 0.25
155 INT199970 CYP19A1 Positive_regulation of Gene_expression of ESR1 1 0.06 0.72 0.25
156 INT126227 Hsp90aa1 Positive_regulation of Nos1 1 0.03 0.73 0.25
157 INT199971 IL6 Positive_regulation of ESR1 1 0.08 0.84 0.24
158 INT258521 EGFR Positive_regulation of MMP2 1 0.39 0.91 0.24
159 INT326094 Akt1 Positive_regulation of Gene_expression of Gopc 1 0.03 0.49 0.24
160 INT326092 Gene_expression of Akt1 Negative_regulation of Gopc 1 0.03 0.55 0.24
161 INT63203 INS Positive_regulation of ESR1 1 0.09 0.3 0.23
162 INT326093 Akt1 Positive_regulation of Gopc 1 0.03 0.43 0.23
163 INT258565 EGFR Positive_regulation of Meta 1 0.39 0.89 0.23
164 INT63198 POMC Positive_regulation of ESR1 1 0.14 0.3 0.23
165 INT265886 IGF1 Positive_regulation of AKT1 1 0.11 3.06 0.23
166 INT272753 Positive_regulation of Prkaca Positive_regulation of EGFR 1 0.01 0 0.23
167 INT270135 Binding of ESR1 and RALA 1 0.11 0.37 0.22
168 INT323173 THRA Positive_regulation of Phosphorylation of Akt1 1 0.00 0 0.22
169 INT63192 PTH Positive_regulation of ESR1 1 0.20 0.29 0.22
170 INT260844 NRP2 Positive_regulation of Akt1 1 0.00 0.73 0.22
171 INT116467 Vegfa Positive_regulation of Akt1 1 0.33 1.41 0.21
172 INT323174 DBT Positive_regulation of Phosphorylation of Akt1 1 0.01 0 0.21
173 INT120716 Binding of AKT1 and TEP1 1 0.05 0.46 0.21
174 INT116468 VEGFA Positive_regulation of Akt1 1 0.04 1.39 0.21
175 INT289356 Binding of Akt1 and Fgf2 1 0.03 0.82 0.21
176 INT309661 C5 Positive_regulation of Phosphorylation of Akt1 1 0.51 0.45 0.21
177 INT221237 Prkca Regulation of Phosphorylation of Akt1 1 0.01 0.28 0.2
178 INT352355 Binding of CNR1 and EGFR 1 0.19 0.76 0.2
179 INT145152 Binding of EGF and EGFR 4 0.15 2.45 0.19
180 INT351086 Negative_regulation of ERBB2 Positive_regulation of Gene_expression of ESR1 1 0.10 0.75 0.19
181 INT224688 Pten Regulation of Akt1 1 0.04 1.12 0.19
182 INT351089 FOXO3 Positive_regulation of Gene_expression of ESR1 1 0.04 0.74 0.19
183 INT324822 Binding of Cd24a and Hsp90aa1 1 0.10 0.71 0.19
184 INT192219 CASP3 Regulation of ESR1 1 0.03 1.19 0.19
185 INT334631 Igf1r Positive_regulation of Phosphorylation of Akt1 1 0.19 0.5 0.18
186 INT303058 Akt1 Negative_regulation of Gene_expression of Syt1 1 0.21 0.43 0.18
187 INT221231 Pdpk1 Positive_regulation of Akt1 1 0.09 0.13 0.18
188 INT221244 Pdpk1 Positive_regulation of Phosphorylation of Akt1 1 0.09 0.13 0.18
189 INT298196 EGFR Positive_regulation of PIK3CD 1 0.04 0.65 0.18
190 INT298192 EGFR Positive_regulation of AKT1 1 0.10 0.65 0.18
191 INT121582 AKT1 Regulation of Gene_expression of GDF15 1 0.21 0.4 0.18
192 INT318324 Binding of AKT1 and PRKCA 1 0.03 0.63 0.18
193 INT253129 Ins1 Regulation of Phosphorylation of Akt1 3 0.11 1.66 0.17
194 INT176133 AKT1 Regulation of BCL2 2 0.12 1.84 0.17
195 INT179841 Il11 Regulation of Positive_regulation of Akt1 1 0.08 0.07 0.17
196 INT105334 PTGER1 Positive_regulation of Positive_regulation of AKT1 1 0.05 0.66 0.17
197 INT282858 Bpifa2 Negative_regulation of Akt1 1 0.05 0.91 0.17
198 INT176134 AKT1 Regulation of Gene_expression of BIRC3 1 0.08 1.09 0.17
199 INT226209 Pik3cb Positive_regulation of Phosphorylation of Akt1 1 0.10 1.16 0.17
200 INT282861 Bpifa2 Negative_regulation of Phosphorylation of Akt1 1 0.05 0.91 0.17

Single Events

The table below shows the top 100 pain related interactions that have been reported for nitric-oxide synthase regulator activity. They are ordered first by their pain relevance and then by number of times they were reported in nitric-oxide synthase regulator activity. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT822 Gene_expression of ESR1 529 0.78 302.16 63.64
2 INT103924 Positive_regulation of Akt1 359 0.69 158.94 60.34
3 INT117713 Phosphorylation of Akt1 275 0.82 95.82 54.34
4 INT40777 Positive_regulation of Akt1 163 0.69 59.41 49.43
5 INT106525 Phosphorylation of Akt1 436 0.82 183.81 47.82
6 INT9082 Positive_regulation of ESR1 238 0.69 148.51 36.69
7 INT114881 Gene_expression of Akt1 227 0.78 102.49 31.81
8 INT112707 Negative_regulation of Akt1 89 0.59 28.85 27.76
9 INT20462 Binding of ESR1 210 0.44 102.7 26.34
10 INT11159 Gene_expression of EGFR 698 0.78 548.93 25.69
11 INT122570 Negative_regulation of Akt1 173 0.59 91.44 25.53
12 INT40776 Gene_expression of Akt1 99 0.77 34.91 24.39
13 INT117718 Positive_regulation of Phosphorylation of Akt1 112 0.69 39.26 24.09
14 INT823 Negative_regulation of ESR1 144 0.58 63.72 22.52
15 INT89396 Phosphorylation of AKT1 225 0.82 111.66 19.61
16 INT86187 Positive_regulation of AKT1 199 0.69 122.13 19.44
17 INT97245 Gene_expression of AKT1 217 0.77 119.63 15.59
18 INT92354 Localization of ESR1 77 0.75 33.04 15.51
19 INT109304 Positive_regulation of Phosphorylation of Akt1 113 0.69 40.92 13.49
20 INT86383 Negative_regulation of EGFR 258 0.59 173.94 13.32
21 INT89395 Negative_regulation of AKT1 127 0.58 70.27 12.54
22 INT79545 Positive_regulation of Gene_expression of ESR1 82 0.64 39.42 12.18
23 INT26534 Regulation of Akt1 34 0.61 14.47 11.86
24 INT19795 Positive_regulation of EGFR 161 0.70 103.69 11.55
25 INT75137 Regulation of Akt1 74 0.48 37.89 9.7
26 INT120967 Negative_regulation of Phosphorylation of Akt1 47 0.57 23.67 8.98
27 INT104396 Positive_regulation of Positive_regulation of Akt1 44 0.55 14.78 8.69
28 INT15687 Regulation of ESR1 91 0.60 40.42 7.95
29 INT106522 Negative_regulation of Phosphorylation of Akt1 65 0.58 34.44 7.83
30 INT57176 Positive_regulation of Dynll1 9 0.49 4.76 7.71
31 INT103925 Negative_regulation of Positive_regulation of Akt1 32 0.58 15.19 7.39
32 INT96994 Phosphorylation of EGFR 99 0.82 52.75 7.33
33 INT74099 Negative_regulation of Dynll1 8 0.56 3.43 7.25
34 INT126748 Positive_regulation of Positive_regulation of Akt1 26 0.55 11.15 7.08
35 INT110987 Transcription of ESR1 45 0.71 24.16 6.72
36 INT11154 Binding of EGFR 149 0.48 96.23 6.29
37 INT117721 Positive_regulation of Gene_expression of Akt1 22 0.69 6.26 6.08
38 INT114882 Positive_regulation of Gene_expression of Akt1 45 0.69 21.29 6.06
39 INT11158 Positive_regulation of Gene_expression of EGFR 165 0.70 131.26 4.93
40 INT105336 Regulation of AKT1 52 0.56 32.53 4.89
41 INT134657 Localization of Akt1 37 0.68 11.58 4.62
42 INT133630 Negative_regulation of Gene_expression of ESR1 42 0.52 23.89 4.57
43 INT122569 Negative_regulation of Gene_expression of Akt1 34 0.54 17.15 4.44
44 INT74393 Gene_expression of Dynll1 8 0.65 2.64 4.39
45 INT109450 Positive_regulation of Phosphorylation of AKT1 62 0.64 25.18 4.21
46 INT75136 Binding of Akt1 27 0.27 8.81 4.15
47 INT139898 Negative_regulation of Positive_regulation of Akt1 15 0.42 4.66 4.06
48 INT120715 Positive_regulation of Egfr 15 0.68 5.53 3.77
49 INT218955 Protein_catabolism of ESR1 9 0.92 3.95 3.74
50 INT119506 Negative_regulation of Egfr 32 0.55 23.75 3.67
51 INT132223 Negative_regulation of Negative_regulation of Akt1 6 0.42 2.75 3.66
52 INT136692 Localization of Akt1 12 0.78 2.14 3.65
53 INT169344 Positive_regulation of Gene_expression of Dynll1 3 0.49 2.34 3.48
54 INT163832 Negative_regulation of Gene_expression of EGFR 50 0.59 39.71 3.45
55 INT178631 Phosphorylation of ESR1 21 0.75 9.16 3.36
56 INT157687 Regulation of Gene_expression of Akt1 9 0.62 4.96 3.27
57 INT108203 Negative_regulation of Gene_expression of AKT1 28 0.54 16.38 3.19
58 INT124954 Gene_expression of Egfr 26 0.75 15.08 3.12
59 INT117348 Regulation of EGFR 75 0.61 47.73 3.09
60 INT117720 Negative_regulation of Gene_expression of Akt1 11 0.37 2.33 3.08
61 INT89392 Negative_regulation of Positive_regulation of AKT1 23 0.50 15.69 3.02
62 INT89401 Negative_regulation of Phosphorylation of AKT1 68 0.58 35.61 2.8
63 INT117715 Regulation of Phosphorylation of Akt1 15 0.51 3.23 2.78
64 INT174727 Positive_regulation of Positive_regulation of ESR1 14 0.44 6.3 2.7
65 INT214355 Binding of Akt1 13 0.36 3.72 2.59
66 INT118791 Binding of AKT1 32 0.48 15.51 2.25
67 INT138286 Regulation of Positive_regulation of Akt1 13 0.45 4.93 2.22
68 INT101866 Positive_regulation of Gene_expression of AKT1 49 0.52 17.47 2.14
69 INT79198 Positive_regulation of Positive_regulation of Dynll1 2 0.42 0.99 1.99
70 INT218959 Negative_regulation of Protein_catabolism of ESR1 3 0.37 0.97 1.9
71 INT65545 Localization of EGFR 35 0.79 20.8 1.88
72 INT123130 Positive_regulation of Positive_regulation of AKT1 22 0.49 11.77 1.83
73 INT77656 Gene_expression of Hsp90aa1 12 0.78 24.27 1.81
74 INT142236 Regulation of Phosphorylation of Akt1 13 0.61 5.02 1.75
75 INT124953 Negative_regulation of Gene_expression of Egfr 6 0.42 1.97 1.75
76 INT165332 Negative_regulation of Negative_regulation of Akt1 5 0.42 3.27 1.7
77 INT117714 Regulation of Positive_regulation of Akt1 3 0.61 0.44 1.61
78 INT167288 Regulation of Dynll1 3 0.45 1.22 1.56
79 INT118292 Negative_regulation of Phosphorylation of EGFR 27 0.59 13.62 1.54
80 INT125320 Negative_regulation of HSP90AA1 20 0.45 23.93 1.42
81 INT96993 Positive_regulation of Phosphorylation of EGFR 15 0.59 5.44 1.37
82 INT88855 Negative_regulation of Hsp90aa1 4 0.54 2.16 1.34
83 INT127725 Negative_regulation of Positive_regulation of EGFR 6 0.57 2.69 1.3
84 INT167409 Regulation of Gene_expression of AKT1 8 0.56 4.86 1.23
85 INT824 Negative_regulation of Negative_regulation of ESR1 3 0.42 1.53 1.18
86 INT135556 Localization of AKT1 38 0.69 12.78 1.17
87 INT118792 Regulation of Positive_regulation of AKT1 8 0.61 3.73 1.15
88 INT176147 Regulation of Phosphorylation of AKT1 14 0.41 6.41 1.13
89 INT133898 Binding of HSP90AA1 17 0.30 8.83 1.12
90 INT207203 Transcription of Akt1 6 0.67 3.73 1.1
91 INT118293 Regulation of Phosphorylation of EGFR 2 0.61 1.01 1.1
92 INT191050 Positive_regulation of Negative_regulation of Akt1 6 0.31 1.82 1.03
93 INT100612 Positive_regulation of Hsp90aa1 4 0.64 5.3 1.01
94 INT71906 Regulation of Gene_expression of ESR1 22 0.41 11.01 0.98
95 INT86384 Negative_regulation of Localization of EGFR 4 0.43 2.5 0.97
96 INT11160 Regulation of Gene_expression of EGFR 27 0.62 22.05 0.96
97 INT154468 Negative_regulation of Transcription of ESR1 3 0.29 1.14 0.96
98 INT134660 Positive_regulation of Localization of Akt1 10 0.32 6.33 0.94
99 INT163508 Regulation of Gene_expression of Akt1 3 0.45 1.65 0.92
100 INT88861 Positive_regulation of Gene_expression of Hsp90aa1 4 0.64 7.43 0.9
101 INT144415 Regulation of Positive_regulation of Egfr 2 0.27 0.42 0.86
102 INT117347 Positive_regulation of Positive_regulation of EGFR 15 0.69 11.17 0.84
103 INT174728 Positive_regulation of Transcription of ESR1 10 0.47 3.3 0.83
104 INT144416 Regulation of Egfr 5 0.57 4.97 0.83
105 INT125092 Negative_regulation of Binding of ESR1 8 0.42 4.15 0.82
106 INT144414 Positive_regulation of Positive_regulation of Egfr 1 0.49 0.65 0.8
107 INT138955 Transcription of EGFR 18 0.71 11.39 0.78
108 INT186119 Protein_catabolism of EGFR 6 0.98 3.68 0.76
109 INT92082 Regulation of Binding of ESR1 5 0.45 2.41 0.73
110 INT151170 Regulation of Regulation of Akt1 2 0.45 3.28 0.73
111 INT114246 Positive_regulation of Negative_regulation of EGFR 13 0.49 8.67 0.7
112 INT299338 Negative_regulation of Regulation of AKT1 2 0.31 2.32 0.68
113 INT186117 Negative_regulation of Protein_catabolism of EGFR 1 0.42 0.67 0.68
114 INT186118 Positive_regulation of Protein_catabolism of EGFR 1 0.68 0.66 0.68
115 INT207204 Regulation of Transcription of Akt1 3 0.35 1.41 0.66
116 INT191177 Regulation of Localization of ESR1 7 0.42 2.04 0.64
117 INT166024 Protein_catabolism of AKT1 5 0.46 2.6 0.64
118 INT281466 Negative_regulation of Regulation of Akt1 1 0.33 0.31 0.63
119 INT192235 Binding of Hsp90aa1 6 0.19 1.46 0.6
120 INT88859 Transcription of Hsp90aa1 1 0.58 1.51 0.6
121 INT166086 Binding of Hsp90aa1 1 0.28 0.08 0.6
122 INT165847 Positive_regulation of HSP90AB1 1 0.60 0.31 0.6
123 INT88857 Negative_regulation of Transcription of Hsp90aa1 1 0.36 1.52 0.6
124 INT123131 Negative_regulation of Negative_regulation of AKT1 6 0.42 3.23 0.58
125 INT165846 Regulation of HSP90AA1 4 0.27 2.19 0.58
126 INT127480 Negative_regulation of Hsp90aa1 20 0.57 10.67 0.56
127 INT320644 Binding of Egfr 7 0.34 5.9 0.56
128 INT165849 Protein_catabolism of HSP90AB1 1 0.56 0.28 0.56
129 INT218900 Regulation of Negative_regulation of Akt1 3 0.15 1.73 0.53
130 INT276189 Regulation of Localization of Akt1 1 0.43 0.2 0.5
131 INT190899 Negative_regulation of Phosphorylation of ESR1 3 0.33 1.01 0.49
132 INT73976 Gene_expression of Hsp90aa1 18 0.75 7.92 0.45
133 INT142943 Phosphorylation of Egfr 5 0.81 1.56 0.45
134 INT142942 Positive_regulation of Phosphorylation of Egfr 4 0.68 1.52 0.45
135 INT88856 Negative_regulation of Gene_expression of Hsp90aa1 2 0.39 2.31 0.45
136 INT174725 Positive_regulation of Localization of ESR1 8 0.47 2.45 0.41
137 INT109486 Positive_regulation of Negative_regulation of Dynll1 1 0.48 0 0.41
138 INT178630 Positive_regulation of Negative_regulation of ESR1 2 0.04 0.64 0.35
139 INT138954 Regulation of Transcription of EGFR 2 0.27 0.82 0.35
140 INT176586 Positive_regulation of Binding of ESR1 11 0.41 4.64 0.33
141 INT145155 Regulation of Positive_regulation of EGFR 6 0.38 4.54 0.33
142 INT186115 Negative_regulation of Negative_regulation of EGFR 5 0.57 3.42 0.33
143 INT293480 Protein_catabolism of Hsp90aa1 2 0.65 0.82 0.32
144 INT321348 Positive_regulation of Localization of Akt1 1 0.30 0.08 0.32
145 INT77654 Regulation of Gene_expression of Hsp90aa1 4 0.62 2.41 0.28
146 INT153772 Negative_regulation of Localization of ESR1 7 0.54 4.42 0.27
147 INT129812 Gene_expression of HSP90AB1 1 0.75 0.72 0.27
148 INT239464 Regulation of Negative_regulation of Akt1 3 0.31 0.37 0.25
149 INT193545 Binding of Dynll1 2 0.36 0.39 0.25
150 INT321170 Positive_regulation of Protein_catabolism of Hsp90aa1 1 0.29 0.2 0.25
151 INT304603 Positive_regulation of HSP90AA1 1 0.26 7.01 0.24
152 INT223597 Negative_regulation of Binding of EGFR 12 0.43 7.97 0.23
153 INT73178 Positive_regulation of Hsp90aa1 4 0.45 0.7 0.21
154 INT200666 Transcription of AKT1 8 0.66 4.23 0.2
155 INT230483 Protein_catabolism of Akt1 2 0.10 1.11 0.2
156 INT276192 Transcription of Akt1 1 0.66 0.47 0.18
157 INT176571 Negative_regulation of Positive_regulation of ESR1 5 0.47 3.15 0.17
158 INT176153 Regulation of Negative_regulation of AKT1 3 0.39 2.13 0.16
159 INT135557 Positive_regulation of Localization of AKT1 3 0.46 0.49 0.15
160 INT144682 Negative_regulation of Regulation of Egfr 1 0.43 0.41 0.15
161 INT226185 Protein_catabolism of Akt1 7 0.53 2.43 0.14
162 INT175416 Regulation of Negative_regulation of EGFR 4 0.60 3.94 0.14
163 INT302248 Negative_regulation of Binding of AKT1 2 0.25 1 0.14
164 INT299514 Localization of Egfr 2 0.37 0.38 0.14
165 INT285902 Positive_regulation of Transcription of AKT1 1 0.06 0.6 0.13
166 INT102355 Gene_expression of HSP90AA1 8 0.51 5.2 0.12
167 INT233419 Negative_regulation of Positive_regulation of Egfr 2 0.40 0.97 0.12
168 INT214360 Negative_regulation of Binding of Akt1 2 0.41 0.09 0.12
169 INT355216 Positive_regulation of Binding of Akt1 1 0.37 0.35 0.12
170 INT199082 Positive_regulation of Binding of Akt1 4 0.17 1.25 0.11
171 INT219647 Negative_regulation of Negative_regulation of Egfr 1 0.19 0.13 0.1
172 INT192236 Positive_regulation of Binding of Hsp90aa1 2 0.24 0.59 0.08
173 INT192239 Positive_regulation of Binding of AKT1 2 0.26 0.91 0.08
174 INT229184 Regulation of Protein_catabolism of EGFR 1 0.25 1.11 0.08
175 INT224299 Positive_regulation of Protein_catabolism of ESR1 3 0.64 1.43 0.07
176 INT266934 Regulation of Binding of EGFR 3 0.45 1.16 0.07
177 INT193543 Localization of Dynll1 1 0.68 0.17 0.07
178 INT307475 Positive_regulation of Negative_regulation of Akt1 1 0.12 0.12 0.07
179 INT178868 Regulation of Positive_regulation of ESR1 1 0.42 0.52 0.07
180 INT182302 Negative_regulation of Localization of AKT1 5 0.39 3.52 0.06
181 INT234206 Localization of HSP90AA1 4 0.68 2.89 0.06
182 INT234211 Regulation of Negative_regulation of HSP90AA1 2 0.27 1.13 0.06
183 INT299512 Regulation of Localization of Egfr 1 0.13 0.11 0.06
184 INT205021 Positive_regulation of Gene_expression of Egfr 3 0.64 4.15 0.05
185 INT234207 Negative_regulation of Binding of HSP90AA1 2 0.26 0.84 0.05
186 INT183275 Positive_regulation of Regulation of EGFR 1 0.36 0.21 0.05
187 INT302546 Regulation of Gene_expression of Hsp90aa1 1 0.21 0.88 0.04
188 INT300989 Positive_regulation of Negative_regulation of AKT1 2 0.41 1.27 0.03
189 INT328544 Localization of Hsp90aa1 1 0.10 0.17 0.03
190 INT279098 Positive_regulation of Dynll1 1 0.17 0 0.03
191 INT234208 Negative_regulation of Localization of HSP90AA1 1 0.26 0.59 0.03
192 INT222086 Positive_regulation of Gene_expression of Hsp90aa1 1 0.24 0 0.03
193 INT145156 Regulation of Regulation of EGFR 1 0.24 1.31 0.03
194 INT288183 Positive_regulation of Regulation of Akt1 1 0.05 0.06 0.03
195 INT174726 Regulation of Regulation of ESR1 1 0.41 0.73 0.03
196 INT266931 Positive_regulation of Binding of EGFR 6 0.50 5.44 0
197 INT234209 Protein_catabolism of HSP90AA1 5 0.54 2.67 0
198 INT234212 Positive_regulation of Gene_expression of HSP90AA1 3 0.41 1.36 0
199 INT268244 Negative_regulation of Localization of Akt1 2 0.28 2 0
200 INT315831 Positive_regulation of Localization of EGFR 2 0.49 0.6 0
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