GO:0030260

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Name entry into host cell
Categary Process
Go Slim No
Go Link GO:0030260
Unique Molecular Interactions 119
Total Molecular Interactions 200
Total Single Events 1760
Pain Genes Associated 4

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for entry into host cell. They are ordered first by their pain relevance and then by number of times they were reported for entry into host cell. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT121651 Binding of CXCL12 and CXCR4 13 0.48 17.61 3.52
2 INT182635 Binding of CCR5 and CCL5 2 0.09 4.19 3
3 INT187175 Binding of BSG and PPIA 1 0.14 2.23 1.64
4 INT241750 Binding of CD4 and ITIH4 14 0.18 5.72 1.53
5 INT174508 Binding of CD4 and HLA-B 1 0.14 4.68 1.53
6 INT106248 Binding of CCR5 and YY1 1 0.54 0.19 0.98
7 INT182190 Binding of IL8 and CXCR4 1 0.26 1.25 0.95
8 INT182210 Binding of CXCR4 and CXCL13 1 0.32 1.25 0.95
9 INT182205 Binding of CXCL5 and CXCR4 1 0.29 1.24 0.94
10 INT182195 Binding of CXCL1 and CXCR4 1 0.13 1.25 0.94
11 INT128652 ITIH4 Regulation of Gene_expression of CCR5 1 0.36 1.46 0.93
12 INT226340 Binding of CD4 and IFNA1 3 0.03 3.84 0.85
13 INT174509 Binding of CD4 and CD28 1 0.26 1.68 0.84
14 INT205120 Binding of CD4 and CD8A 3 0.15 2.83 0.72
15 INT182201 Binding of CXCR5 and CXCR4 1 0.36 1.15 0.72
16 INT182202 Binding of CXCR2 and CXCR4 1 0.31 1.15 0.72
17 INT239538 Binding of CXCR4 and CALCRL 1 0.00 0.35 0.71
18 INT254352 Binding of CXCR4 and Positive_regulation of Gene_expression of CXCL12 1 0.14 1.8 0.66
19 INT106247 Binding of CCR5 and CCL4 1 0.54 0.06 0.64
20 INT174500 Positive_regulation of Binding of CD4 and HLA-B 1 0.21 2.33 0.63
21 INT62299 Binding of CD4 and SGCG 1 0.39 1.23 0.51
22 INT251297 Binding of C2 and CD4 1 0.04 0.35 0.47
23 INT178664 Binding of CCR5 and TH1L 1 0.04 1.04 0.44
24 INT208461 Binding of CD4 and IL16 1 0.05 3.04 0.41
25 INT330515 TNFSF10 Regulation of Gene_expression of CD4 1 0.29 1.24 0.4
26 INT330518 TNFSF10 Regulation of CD4 1 0.29 1.24 0.4
27 INT117184 GOLPH3 Regulation of CXCR4 1 0.30 0.29 0.37
28 INT273172 Negative_regulation of PDE4A Negative_regulation of Localization of CD4 1 0.11 0.74 0.37
29 INT226350 MBTPS1 Negative_regulation of Gene_expression of CD4 1 0.03 0.61 0.37
30 INT226374 Negative_regulation of Binding of CD4 and IFNA1 1 0.03 0.66 0.37
31 INT117182 GOLPH3 Regulation of Binding of CXCR4 1 0.50 0.29 0.37
32 INT27030 HERPUD1 Regulation of CD4 1 0.41 0 0.34
33 INT188391 Binding of CD4 and HLA-DRB1 1 0.05 0.96 0.34
34 INT27037 HERPUD1 Regulation of Gene_expression of CD4 1 0.55 0 0.34
35 INT278693 ERAL1 Positive_regulation of CD4 1 0.05 1.1 0.31
36 INT278692 ERAL1 Positive_regulation of Positive_regulation of CD4 1 0.05 1.1 0.31
37 INT174499 Binding of CD4 and HLA-E 1 0.04 1.08 0.29
38 INT245072 PPARA Regulation of Gene_expression of CXCR4 1 0.07 0.68 0.26
39 INT194670 CREB1 Regulation of Gene_expression of CD4 1 0.05 0.07 0.25
40 INT330521 Binding of CD4 and TNFSF10 1 0.20 0.73 0.24
41 INT352081 Binding of CD4 and ADAM11 1 0.09 0.33 0.24
42 INT88310 ITIH4 Positive_regulation of CXCR4 2 0.27 1.98 0.23
43 INT241822 Binding of CD4 and HIVEP1 3 0.01 2.73 0.21
44 INT182634 Binding of CCR5 and MIP 2 0.39 1.29 0.2
45 INT252821 Binding of CD4 and IL12A 1 0.02 1.36 0.19
46 INT188570 Negative_regulation of IRF6 Positive_regulation of CD4 1 0.04 0.19 0.19
47 INT188573 IRF6 Positive_regulation of CD4 1 0.05 0.19 0.19
48 INT193787 Positive_regulation of CXCR4 Positive_regulation of Positive_regulation of TP53 1 0.03 0.71 0.19
49 INT274386 Binding of CD4 and ERVW-1 1 0.05 3.07 0.18
50 INT117183 Binding of CXCR4 and GOLPH3 1 0.53 0.27 0.16
51 INT88311 ITIH4 Positive_regulation of CCR5 1 0.49 1.57 0.16
52 INT188569 Binding of CD4 and TLR4 1 0.16 0.34 0.16
53 INT117191 Binding of CXCR4 and Coro1a 1 0.39 0.28 0.16
54 INT193779 Positive_regulation of ITIH4 Positive_regulation of CXCR4 1 0.19 0.83 0.15
55 INT291349 CXCR4 Positive_regulation of EPHB2 1 0.42 1.87 0.13
56 INT10731 NEUROD1 Regulation of CD4 1 0.42 1.3 0.12
57 INT10730 CD9 Regulation of CD4 1 0.42 1.3 0.12
58 INT251295 Binding of CD4 and Regulation of ITIH4 1 0.11 0.24 0.11
59 INT241748 CCR5 Regulation of CD4 1 0.21 0.39 0.11
60 INT189144 MTNR1B Positive_regulation of Gene_expression of CD4 1 0.01 0.35 0.11
61 INT294441 KLK4 Negative_regulation of CXCR4 1 0.01 0 0.1
62 INT333099 Localization of IL2 Negative_regulation of Negative_regulation of CD4 1 0.14 0.8 0.09
63 INT292632 CD4 Positive_regulation of Gene_expression of IL9 1 0.24 0 0.09
64 INT333094 HIVEP1 Regulation of CD4 1 0.00 0.22 0.09
65 INT182644 Binding of CXCR4 and Cxcr4 1 0.10 0.66 0.09
66 INT333089 CD4 Positive_regulation of ERVW-1 1 0.05 0.07 0.08
67 INT342288 Binding of CD4 and HFE 1 0.01 1.26 0.08
68 INT15953 Binding of CD4 and IgG2a 1 0.54 0.38 0.08
69 INT183768 Csf2 Regulation of CD4 1 0.37 0.52 0.08
70 INT333096 Binding of CD4 and IFN1@ 1 0.12 0.17 0.07
71 INT333092 Binding of CD4 and IL2 1 0.01 0.17 0.07
72 INT166732 BATF Negative_regulation of PPIA 1 0.05 1.45 0.06
73 INT335715 Binding of FASLG and CD4 1 0.22 0.9 0.06
74 INT335714 Binding of FAS and CD4 1 0.38 0.9 0.06
75 INT333091 Localization of IFN1@ Negative_regulation of Negative_regulation of CD4 1 0.14 0.4 0.05
76 INT233303 Binding of CD4 and SRY 1 0.07 0.34 0.05
77 INT241751 Negative_regulation of Binding of CD4 and ITIH4 3 0.18 1.07 0.04
78 INT329102 Binding of CD4 and HLA-DQA2 2 0.04 0.92 0.04
79 INT241752 ITIH4 Negative_regulation of Binding of CXCR4 1 0.08 0.71 0.04
80 INT283464 Binding of CD4 and DLAT 1 0.07 0.69 0.04
81 INT251296 Binding of CCR5 and ITIH4 1 0.16 0.08 0.04
82 INT241749 ITIH4 Negative_regulation of Binding of CCR5 1 0.16 0.71 0.04
83 INT286968 Positive_regulation of STAT3 Regulation of Gene_expression of CD4 1 0.16 0.44 0.04
84 INT286962 IL2 Regulation of Gene_expression of CD4 1 0.01 0.45 0.04
85 INT212584 IFNA1 Regulation of Gene_expression of CD4 1 0.21 0.98 0.03
86 INT308540 CD4 Regulation of Localization of AGRP 1 0.39 0.85 0.03
87 INT183767 Csf2 Negative_regulation of Transcription of CCR5 1 0.17 0.92 0.03
88 INT245076 CXCR4 Regulation of Gene_expression of VEGFA 1 0.16 1.05 0.03
89 INT183769 Csf2 Negative_regulation of Transcription of CXCR4 1 0.48 0.92 0.03
90 INT183757 INCENP Negative_regulation of Transcription of CXCR4 1 0.01 0.93 0.03
91 INT221262 Binding of BRCA1 and CD4 1 0.22 0.81 0.03
92 INT183758 INCENP Negative_regulation of Transcription of CCR5 1 0.00 0.93 0.03
93 INT291357 CXCR4 Positive_regulation of AKT1 1 0.08 1.27 0.03
94 INT121650 Negative_regulation of Binding of CXCL12 and CXCR4 2 0.47 1.61 0
95 INT121652 Binding of CCR5 and CXCL12 1 0.33 0.2 0
96 INT245078 FGF2 Positive_regulation of CXCR4 1 0.07 1.36 0
97 INT326167 Binding of CD4 and Tmed8 1 0.47 0.29 0
98 INT245073 VEGFA Positive_regulation of CXCR4 1 0.27 5.09 0
99 INT260127 Binding of CD4 and Trav6-3 1 0.03 0 0
100 INT245074 Gene_expression of VHL Negative_regulation of Gene_expression of CXCR4 1 0.31 1.84 0
101 INT328477 Mkrn1 Positive_regulation of CCR5 1 0.01 0.69 0
102 INT121649 Binding of CD4 and CXCL12 1 0.29 0.2 0
103 INT343501 CD4 Regulation of ERVW-1 1 0.09 0.16 0
104 INT240420 Myo5a Positive_regulation of CD4 1 0.06 0.27 0
105 INT277809 Binding of CD4 and CD40LG 1 0.15 0 0
106 INT329101 Binding of CD4 and INCENP 1 0.01 0.11 0
107 INT343499 CD4 Regulation of HIVEP1 1 0.02 0.16 0
108 INT205121 Binding of CD4 and CD7 1 0.05 0.51 0
109 INT340516 CD4 Regulation of IL2 1 0.04 0.32 0
110 INT258911 Binding of CD4 and HLA-G 1 0.04 0.06 0
111 INT235494 SFTPA1 Positive_regulation of Positive_regulation of CD4 1 0.01 0 0
112 INT275190 Localization of CD4 Positive_regulation of Positive_regulation of LCK 1 0.10 0.99 0
113 INT188750 Binding of CD4 and ADC 1 0.16 0.93 0
114 INT336169 Binding of HIVEP1 and CXCR4 1 0.01 0.44 0
115 INT336168 Binding of CCR5 and HIVEP1 1 0.01 0.44 0
116 INT353129 Binding of CD4 and CXCR4 1 0.13 1.08 0
117 INT174502 HLA-B Regulation of CD4 1 0.13 0 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for entry into host cell. They are ordered first by their pain relevance and then by number of times they were reported in entry into host cell. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT13556 Gene_expression of CD4 367 0.78 230.82 41.74
2 INT88322 Gene_expression of CCR5 111 0.78 77.36 39.84
3 INT88318 Gene_expression of CXCR4 208 0.77 189.67 31.72
4 INT5328 Positive_regulation of CD4 191 0.69 133.43 21.31
5 INT89293 Positive_regulation of Gene_expression of CCR5 29 0.70 22.14 15
6 INT10709 Negative_regulation of CD4 106 0.59 95.6 14.89
7 INT36287 Binding of CD4 96 0.47 58.93 11.88
8 INT16404 Regulation of CD4 54 0.61 33.05 10.29
9 INT89292 Positive_regulation of CCR5 27 0.70 15.12 8.59
10 INT91758 Binding of CCR5 28 0.45 20.16 7.07
11 INT17049 Localization of CD4 57 0.75 35.33 6.89
12 INT117186 Positive_regulation of CXCR4 29 0.69 24.19 6.84
13 INT107315 Negative_regulation of CCR5 22 0.57 13.82 6.11
14 INT122653 Positive_regulation of Gene_expression of CD4 48 0.68 22.5 5.96
15 INT117189 Binding of CXCR4 34 0.37 24.27 5.81
16 INT113112 Negative_regulation of CXCR4 39 0.58 28.28 5.36
17 INT170528 Negative_regulation of Gene_expression of CD4 25 0.41 17.98 3.6
18 INT103674 Positive_regulation of Gene_expression of CXCR4 32 0.69 37.1 3.08
19 INT110233 Regulation of Gene_expression of CCR5 6 0.34 7.14 2.76
20 INT106433 Regulation of CCR5 11 0.59 6.93 2.75
21 INT232510 Negative_regulation of Gene_expression of CXCR4 18 0.58 20.27 2.54
22 INT113775 Negative_regulation of Gene_expression of CCR5 6 0.43 3.97 2.28
23 INT113111 Regulation of CXCR4 14 0.61 12.81 1.39
24 INT174486 Regulation of Gene_expression of CD4 12 0.36 6.09 1.39
25 INT193815 Regulation of Gene_expression of CXCR4 17 0.61 20.27 1.15
26 INT241757 Localization of CCR5 6 0.71 5.7 1.14
27 INT187188 Binding of PPIA 3 0.47 1.1 1.01
28 INT182211 Transcription of CXCR4 5 0.69 3.8 0.95
29 INT264171 Positive_regulation of Positive_regulation of CD4 5 0.49 4.74 0.94
30 INT189171 Positive_regulation of Localization of CD4 7 0.49 5.88 0.79
31 INT19218 Negative_regulation of Positive_regulation of CD4 9 0.41 9.21 0.69
32 INT202428 Positive_regulation of Binding of CD4 4 0.37 2.11 0.68
33 INT171946 Positive_regulation of Binding of CCR5 1 0.47 3.86 0.66
34 INT193811 Localization of CXCR4 6 0.75 7.68 0.58
35 INT202427 Negative_regulation of Localization of CD4 2 0.32 3.1 0.56
36 INT260124 Positive_regulation of Positive_regulation of CCR5 1 0.14 0.84 0.51
37 INT164518 Gene_expression of PPIA 7 0.75 3.92 0.5
38 INT202426 Transcription of CD4 6 0.69 3.96 0.49
39 INT260119 Regulation of Localization of CD4 2 0.44 1.61 0.46
40 INT260118 Regulation of Regulation of CD4 1 0.44 1.66 0.4
41 INT193814 Positive_regulation of Positive_regulation of CXCR4 2 0.38 3.08 0.39
42 INT287286 Positive_regulation of Binding of CXCR4 2 0.53 0.78 0.39
43 INT187184 Localization of PPIA 1 0.27 0.64 0.37
44 INT221044 Positive_regulation of Negative_regulation of CCR5 1 0.19 0.62 0.35
45 INT260110 Positive_regulation of Regulation of CD4 2 0.48 1.5 0.32
46 INT282775 Regulation of Positive_regulation of CD4 2 0.37 1.28 0.3
47 INT212592 Regulation of Binding of CD4 2 0.30 1.15 0.3
48 INT245085 Positive_regulation of Negative_regulation of CXCR4 1 0.47 1.7 0.23
49 INT204183 Negative_regulation of Negative_regulation of CD4 3 0.30 1.79 0.22
50 INT104449 Transcription of CCR5 4 0.53 2.73 0.21
51 INT296064 Positive_regulation of Transcription of CD4 1 0.28 0.11 0.21
52 INT107316 Negative_regulation of Positive_regulation of CCR5 2 0.41 1.96 0.17
53 INT166737 Positive_regulation of Gene_expression of PPIA 1 0.68 2.5 0.15
54 INT20433 Regulation of Phosphorylation of CD4 1 0.06 0 0.13
55 INT20434 Phosphorylation of CD4 2 0.61 0 0.12
56 INT241759 Negative_regulation of Binding of CCR5 2 0.41 0.94 0.11
57 INT203282 Negative_regulation of Binding of CD4 2 0.30 0.63 0.11
58 INT166739 Positive_regulation of PPIA 1 0.45 1.39 0.06
59 INT183764 Negative_regulation of Transcription of CXCR4 1 0.41 0.91 0.03
60 INT183763 Negative_regulation of Transcription of CCR5 1 0.15 0.92 0.03
61 INT245080 Regulation of Negative_regulation of CXCR4 1 0.45 0.78 0.03
62 INT273759 Positive_regulation of Negative_regulation of CD4 2 0.45 2.05 0
63 INT290522 Regulation of PPIA 1 0.04 0.18 0
64 INT291075 Regulation of Gene_expression of PPIA 1 0.31 0.35 0
65 INT322320 Transcription of PPIA 1 0.30 0.67 0
66 INT166738 Negative_regulation of PPIA 1 0.42 1.2 0
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