GO:0030275

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Name LRR domain binding
Categary Function
Go Slim No
Go Link GO:0030275
Unique Molecular Interactions 54
Total Molecular Interactions 88
Total Single Events 610
Pain Genes Associated 8

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for LRR domain binding. They are ordered first by their pain relevance and then by number of times they were reported for LRR domain binding. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT147506 Binding of Ncam1 and Gtf3a 1 0.03 0.88 0.99
2 INT147504 Binding of Ncam1 and Gdnf 1 0.31 0.87 0.98
3 INT59201 ecs Positive_regulation of Ncam1 1 0.01 0.98 0.59
4 INT155881 Binding of CDX2 and KRAS 1 0.40 1.51 0.47
5 INT346218 Positive_regulation of Kras Positive_regulation of Phosphorylation of Mdk 1 0.01 0.71 0.42
6 INT346220 Binding of Kras and Braf 1 0.03 0.58 0.28
7 INT187486 Binding of Prkag1 and Stk11 1 0.01 0.95 0.22
8 INT317394 Binding of Stk11 and Amp1 1 0.04 0.89 0.21
9 INT316072 Binding of Cd3e and Ncam1 1 0.01 0.4 0.18
10 INT262618 Binding of SOAT1 and Kras 1 0.00 0.81 0.12
11 INT351974 Agt Positive_regulation of Gene_expression of Stk11 1 0.51 11.1 0.12
12 INT189559 STK11 Positive_regulation of SNRK 1 0.03 0.36 0.11
13 INT317392 Negative_regulation of Binding of Stk11 and Amp1 1 0.05 0.34 0.1
14 INT326382 Binding of Gdnf and Ncam1 1 0.01 0.3 0.08
15 INT317398 Amp1 Positive_regulation of Phosphorylation of Stk11 1 0.05 0.22 0.07
16 INT317391 Amp1 Positive_regulation of Stk11 1 0.05 0.22 0.07
17 INT253139 Il6 Positive_regulation of Phosphorylation of Stk11 1 0.26 0.34 0.07
18 INT317389 Binding of Prkag1 and Stk11 1 0.16 0.2 0.06
19 INT317397 Negative_regulation of Binding of Prkag1 and Stk11 1 0.19 0.2 0.06
20 INT317388 Stk11 Regulation of Positive_regulation of Prkag1 1 0.23 0.11 0.03
21 INT317404 Acc Positive_regulation of Stk11 1 0.41 0.06 0.03
22 INT172980 Binding of VEGFA and Kras 1 0.00 0.79 0
23 INT351972 Binding of Agt and Stk11 1 0.27 0.74 0
24 INT232057 Binding of KRAS and RNPC3 1 0.00 0.31 0
25 INT215698 Lamtor1 Negative_regulation of Kras 1 0.00 0 0
26 INT351975 Agt Positive_regulation of Stk11 1 0.34 0.39 0
27 INT350426 Binding of BRAF and KRAS 1 0.05 1.78 0
28 INT268397 Binding of Kras and Regulation of ARAF 1 0.03 1.16 0
29 INT180666 Fn1 Regulation of Transcription of Kras 1 0.31 0 0
30 INT232051 Binding of FOXM1 and KRAS 1 0.00 0.63 0
31 INT351984 Gene_expression of Stk11 Positive_regulation of Gene_expression of Dcc 1 0.01 1.8 0
32 INT180669 Fn1 Regulation of Kras 1 0.18 0 0
33 INT351982 Smarca4 Positive_regulation of Stk11 1 0.05 0.58 0
34 INT215696 Cdkn2a Negative_regulation of Kras 1 0.00 0 0
35 INT215702 Stmn1 Negative_regulation of Kras 1 0.00 0 0
36 INT319319 Binding of EGFR and KRAS 1 0.22 0.27 0
37 INT351985 Stk11 Positive_regulation of Gene_expression of Dcc 1 0.01 1.79 0
38 INT268395 Binding of APC and Kras 1 0.04 1.21 0
39 INT351976 Binding of Tp53 and Stk11 1 0.13 2.3 0
40 INT151589 Stk11 Positive_regulation of Prkag1 1 0.41 0.17 0
41 INT215688 Cdkn2b Negative_regulation of Kras 1 0.00 0 0
42 INT350433 KRAS Regulation of Gene_expression of BRAF 1 0.08 1.77 0
43 INT259094 STK11 Positive_regulation of Gene_expression of TCEAL1 1 0.18 5.5 0
44 INT258716 Camk1g Positive_regulation of Kras 1 0.02 0.08 0
45 INT215703 Binding of Kras and Cdk6 1 0.01 0 0
46 INT265547 Positive_regulation of Tp53 Positive_regulation of Gene_expression of Kras 1 0.01 0.93 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for LRR domain binding. They are ordered first by their pain relevance and then by number of times they were reported in LRR domain binding. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT18672 Gene_expression of Ncam1 54 0.78 36.64 18.79
2 INT133905 Gene_expression of Ncam1 24 0.78 10.2 4.62
3 INT137691 Positive_regulation of Gene_expression of Ncam1 9 0.68 2.3 4.24
4 INT56027 Positive_regulation of Ncam1 12 0.69 4.96 4.1
5 INT137688 Regulation of Gene_expression of Ncam1 1 0.60 1.21 3.65
6 INT53706 Positive_regulation of Kras 13 0.67 9.26 3.57
7 INT111039 Gene_expression of Kras 20 0.60 15.42 2.39
8 INT137690 Negative_regulation of Gene_expression of Ncam1 3 0.50 3.37 2.18
9 INT133906 Positive_regulation of Gene_expression of Ncam1 6 0.70 1.9 2
10 INT56028 Regulation of Ncam1 6 0.38 3.6 1.78
11 INT109975 Positive_regulation of Kras 14 0.45 12.72 1.68
12 INT133904 Positive_regulation of Ncam1 7 0.50 4.01 1.57
13 INT93624 Negative_regulation of Kras 3 0.41 1.15 1.52
14 INT92383 Gene_expression of KRAS 38 0.65 32.94 1.32
15 INT60060 Positive_regulation of KRAS 17 0.67 11.68 1.21
16 INT204058 Regulation of Gene_expression of Kras 4 0.24 7.54 1.01
17 INT111035 Positive_regulation of Gene_expression of Kras 5 0.31 3.31 0.99
18 INT92382 Positive_regulation of Gene_expression of KRAS 7 0.49 4.82 0.71
19 INT78800 Negative_regulation of Ncam1 2 0.36 0.58 0.69
20 INT93622 Positive_regulation of Negative_regulation of Kras 1 0.49 0.49 0.61
21 INT144700 Gene_expression of Kras 21 0.41 12.28 0.57
22 INT253108 Phosphorylation of Stk11 4 0.65 2.13 0.52
23 INT95163 Binding of Ncam1 3 0.32 1.02 0.5
24 INT95161 Localization of Ncam1 5 0.80 1.01 0.45
25 INT171223 Regulation of Ncam1 5 0.20 3.81 0.43
26 INT98708 Binding of KRAS 13 0.47 7.47 0.39
27 INT351970 Gene_expression of Stk11 1 0.75 33.89 0.35
28 INT98203 Negative_regulation of KRAS 5 0.42 2.38 0.34
29 INT196913 Regulation of Kras 3 0.10 3.81 0.28
30 INT89620 Phosphorylation of Ncam1 1 0.19 0.52 0.28
31 INT114788 Negative_regulation of Positive_regulation of Kras 1 0.04 0.65 0.28
32 INT29141 Binding of Kras 3 0.15 0.81 0.27
33 INT95162 Negative_regulation of Localization of Ncam1 2 0.37 0.17 0.24
34 INT56026 Positive_regulation of Regulation of Ncam1 1 0.37 0.24 0.22
35 INT260506 Binding of Ncam1 2 0.20 0.1 0.2
36 INT117439 Negative_regulation of Positive_regulation of Kras 1 0.42 1.31 0.2
37 INT351969 Positive_regulation of Gene_expression of Stk11 1 0.67 21.03 0.19
38 INT196603 Gene_expression of STK11 5 0.55 6.75 0.15
39 INT189633 Regulation of STK11 3 0.41 3.57 0.14
40 INT202816 Negative_regulation of Ncam1 3 0.30 0.64 0.14
41 INT252012 Negative_regulation of Positive_regulation of Ncam1 1 0.22 1.3 0.14
42 INT106227 Binding of STK11 3 0.42 3.13 0.13
43 INT189583 Transcription of STK11 2 0.49 4.43 0.13
44 INT330233 Positive_regulation of Stk11 2 0.67 8.15 0.13
45 INT151587 Positive_regulation of Stk11 2 0.38 0.44 0.12
46 INT214943 Negative_regulation of Gene_expression of Kras 2 0.13 0.05 0.12
47 INT208202 Localization of Ncam1 2 0.42 0.56 0.11
48 INT127918 Negative_regulation of Kras 2 0.17 0.66 0.08
49 INT326201 Positive_regulation of Gene_expression of Kras 2 0.02 1.06 0.08
50 INT331321 Protein_catabolism of KRAS 1 0.07 0.97 0.08
51 INT127916 Localization of Kras 1 0.29 0 0.08
52 INT253107 Regulation of Stk11 2 0.33 0.3 0.07
53 INT253102 Negative_regulation of Stk11 1 0.31 0.22 0.07
54 INT142555 Positive_regulation of Positive_regulation of Kras 1 0.35 0.6 0.07
55 INT207240 Regulation of Gene_expression of KRAS 2 0.28 1.31 0.06
56 INT330228 Phosphorylation of Stk11 1 0.18 0.27 0.05
57 INT330227 Positive_regulation of Positive_regulation of Stk11 1 0.11 0.06 0.05
58 INT294235 Negative_regulation of Binding of KRAS 1 0.05 0 0.05
59 INT247634 Negative_regulation of Localization of Ncam1 1 0.05 0.1 0.05
60 INT351967 Negative_regulation of Gene_expression of Stk11 1 0.57 0.89 0.04
61 INT351966 Binding of Stk11 1 0.36 2.15 0.04
62 INT207233 Transcription of KRAS 3 0.48 1.56 0.03
63 INT253104 Gene_expression of Stk11 2 0.53 0.07 0.03
64 INT317354 Regulation of Phosphorylation of Stk11 1 0.36 0.12 0.03
65 INT348616 Negative_regulation of Gene_expression of KRAS 1 0.31 0.34 0.03
66 INT236621 Regulation of KRAS 7 0.53 6.16 0
67 INT180396 Localization of KRAS 3 0.69 2.89 0
68 INT304076 Regulation of Localization of KRAS 2 0.36 2.39 0
69 INT175421 Positive_regulation of Positive_regulation of KRAS 2 0.34 1.45 0
70 INT259109 Negative_regulation of STK11 2 0.54 2.11 0
71 INT326360 Phosphorylation of Ncam1 1 0.44 0.28 0
72 INT351968 Negative_regulation of Stk11 1 0.42 4.84 0
73 INT315376 Negative_regulation of Binding of Kras 1 0.04 0.12 0
74 INT351971 Regulation of Stk11 1 0.26 0.43 0
75 INT178925 Negative_regulation of Gene_expression of Kras 1 0.07 1.34 0
76 INT317352 Positive_regulation of Phosphorylation of Stk11 1 0.32 0 0
77 INT242091 Phosphorylation of STK11 1 0.30 1.93 0
78 INT301374 Localization of Stk11 1 0.23 1.58 0
79 INT268347 Binding of Kras 1 0.06 2.44 0
80 INT180682 Transcription of Kras 1 0.67 0 0
81 INT326200 Regulation of Gene_expression of Kras 1 0.03 0 0
82 INT326199 Phosphorylation of Kras 1 0.04 0 0
83 INT315374 Regulation of Kras 1 0.02 0.24 0
84 INT268346 Positive_regulation of Binding of Kras 1 0.08 1.41 0
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