GO:0030282

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Name bone mineralization
Categary Process
Go Slim No
Go Link GO:0030282
Unique Molecular Interactions 336
Total Molecular Interactions 433
Total Single Events 5344
Pain Genes Associated 33

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for bone mineralization. They are ordered first by their pain relevance and then by number of times they were reported for bone mineralization. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT77807 Edn1 Positive_regulation of Gene_expression of Ptgs2 1 0.33 0.53 2.1
2 INT190773 Il4 Negative_regulation of Gene_expression of Ptgs2 1 0.06 1.26 1.45
3 INT190774 Il4 Negative_regulation of Positive_regulation of Ptgs2 1 0.06 1.26 1.45
4 INT150682 Pomc Regulation of Gene_expression of Eif2ak3 1 0.37 0.17 1.44
5 INT126639 KNG1 Positive_regulation of Alox15 1 0.17 0.62 1.36
6 INT126640 Negative_regulation of KNG1 Positive_regulation of Alox15 1 0.14 0.62 1.36
7 INT77806 Edn1 Regulation of Gene_expression of Ptgs2 1 0.29 1.24 1.22
8 INT195117 Ptgs2 Positive_regulation of Gene_expression of Il6 1 0.10 3.26 1.16
9 INT126401 ITIH4 Positive_regulation of Gene_expression of Ptgs2 1 0.00 1.05 1.04
10 INT65986 IL1B Positive_regulation of PTGS2 3 0.32 2.05 1.03
11 INT60213 Binding of Ptgs1 and Ptgs2 2 0.37 0.5 0.97
12 INT210783 Bmp2 Positive_regulation of Tnip1 1 0.40 0.53 0.94
13 INT210791 Bmp2 Positive_regulation of Net1 1 0.38 0.52 0.93
14 INT210799 Bmp2 Positive_regulation of B2m 1 0.35 0.52 0.92
15 INT101259 Gata6 Negative_regulation of Gene_expression of ALOX15 1 0.42 0.67 0.89
16 INT101258 Gene_expression of Gata6 Negative_regulation of Positive_regulation of ALOX15 1 0.42 0.65 0.87
17 INT116559 Olr1627 Negative_regulation of Regulation of Ptgs2 1 0.01 1.52 0.86
18 INT194856 Positive_regulation of Adora2b Negative_regulation of Positive_regulation of Mmp13 1 0.01 0.73 0.85
19 INT183176 Binding of FGFR2 and NUDT6 1 0.05 1.07 0.84
20 INT149628 Il1b Regulation of Gene_expression of Ptgs2 1 0.30 0.84 0.84
21 INT150680 Pomc Negative_regulation of Gene_expression of Eif2ak3 1 0.35 0.07 0.8
22 INT62176 Binding of PTGS2 and Ptgs1 2 0.00 0.69 0.79
23 INT200094 Negative_regulation of Jun Negative_regulation of Gene_expression of Ptgs2 1 0.01 2.87 0.78
24 INT158068 Positive_regulation of Pparg Positive_regulation of Positive_regulation of PTGS2 1 0.01 0.28 0.76
25 INT162241 Binding of COL7A1 and MMP13 2 0.03 0.86 0.73
26 INT65985 IL1B Positive_regulation of Gene_expression of PTGS2 3 0.23 2.62 0.71
27 INT186674 Binding of BGLAP and CYP27A1 1 0.01 1.91 0.71
28 INT122823 ERCC2 Regulation of Negative_regulation of OPRM1 1 0.23 0.17 0.63
29 INT182266 EDN1 Positive_regulation of Gene_expression of MMP13 1 0.35 2.03 0.63
30 INT71942 Negative_regulation of PTGS2 Negative_regulation of VN1R106P 1 0.00 0.07 0.62
31 INT101320 Negative_regulation of Ptgs1 Positive_regulation of Ptgs2 1 0.03 0.2 0.62
32 INT71944 PTGS2 Negative_regulation of VN1R106P 1 0.00 0.07 0.61
33 INT178087 EDN1 Positive_regulation of MMP13 2 0.23 1.58 0.59
34 INT137247 Slc6a14 Negative_regulation of Ptgs2 2 0.19 1.38 0.58
35 INT137248 Slc6a14 Negative_regulation of Gene_expression of Ptgs2 1 0.19 1.32 0.58
36 INT125546 Arsa Negative_regulation of Gene_expression of PTGS2 1 0.00 0.53 0.58
37 INT87294 SERPINA3 Negative_regulation of PTGS2 1 0.25 0.6 0.58
38 INT345303 MMP15 Positive_regulation of MMP13 1 0.00 1.18 0.58
39 INT254197 Mif Regulation of Ptgs2 1 0.02 1.08 0.55
40 INT71943 Regulation of ZNF697 Negative_regulation of PTGS2 1 0.01 0.07 0.54
41 INT129912 Skiv2l Negative_regulation of Gene_expression of PTGS2 1 0.00 0.87 0.54
42 INT202043 MMP13 Regulation of Protein_catabolism of COL2A1 1 0.01 0.54 0.54
43 INT161251 Ptgs2 Regulation of Mapk14 1 0.16 0.82 0.54
44 INT71945 ZNF697 Negative_regulation of PTGS2 1 0.01 0.07 0.53
45 INT69882 Ptger2 Positive_regulation of Gene_expression of Ptgs2 1 0.19 0.6 0.52
46 INT116541 Binding of Ptgs2 and ZNF398 1 0.00 0.68 0.52
47 INT235390 HTR1A Regulation of BGLAP 1 0.03 0.23 0.51
48 INT150205 Tnrc6a Negative_regulation of PTGS2 1 0.00 0.42 0.49
49 INT135584 CSF2 Regulation of PTGS2 1 0.06 1.28 0.49
50 INT173597 Negative_regulation of Binding of MMP2 and Mmp13 1 0.14 0.83 0.48
51 INT173595 Binding of MMP2 and Mmp13 1 0.12 0.83 0.48
52 INT150788 ZNF398 Regulation of PTGS2 1 0.02 0.5 0.48
53 INT348402 LPA Positive_regulation of Gene_expression of Ptgs2 1 0.01 0.62 0.48
54 INT173596 Binding of MMP3 and Mmp13 1 0.06 0.84 0.48
55 INT173598 Negative_regulation of Binding of MMP3 and Mmp13 1 0.06 0.84 0.48
56 INT62164 Il1b Positive_regulation of PTGS2 1 0.00 0.49 0.47
57 INT62163 Il1b Positive_regulation of Positive_regulation of PTGS2 1 0.00 0.49 0.47
58 INT145434 Binding of HMOX1 and PTGS2 1 0.02 0.41 0.47
59 INT145436 Binding of HMOX2 and PTGS2 1 0.02 0.41 0.47
60 INT127662 Negative_regulation of PDE4A Negative_regulation of Gene_expression of PTGS2 1 0.15 0.75 0.47
61 INT210793 Bmp2 Positive_regulation of Tsc22d3 1 0.32 0.26 0.46
62 INT345305 MMP14 Positive_regulation of MMP13 1 0.00 0.33 0.45
63 INT224686 S100a4 Positive_regulation of Gene_expression of Mmp13 1 0.05 0.85 0.45
64 INT235389 Binding of BGLAP and HTR1A 1 0.03 0.15 0.45
65 INT241679 EIF2AK3 Positive_regulation of Atf4 1 0.06 0.46 0.4
66 INT106505 Binding of Ptgds and Ptgs2 1 0.01 0.93 0.39
67 INT200096 Negative_regulation of Il1a Negative_regulation of Gene_expression of Ptgs2 1 0.00 1.45 0.39
68 INT312086 ELANE Positive_regulation of MMP13 1 0.13 0.64 0.39
69 INT157171 Binding of PTGS2 and Pla2g1b 1 0.02 0.26 0.37
70 INT296306 Binding of BGLAP and SPIN1 1 0.05 1.69 0.37
71 INT288164 Jun Regulation of Gene_expression of Mmp13 1 0.02 0.41 0.35
72 INT278766 HOXA9 Positive_regulation of Gene_expression of PTGS2 1 0.43 1.28 0.35
73 INT288167 Ugcg Negative_regulation of Gene_expression of Mmp13 1 0.06 0.46 0.35
74 INT278749 NUP98 Positive_regulation of Gene_expression of PTGS2 1 0.46 1.28 0.35
75 INT89501 Il6 Positive_regulation of Ptgs2 1 0.01 1.07 0.35
76 INT89505 Nos2 Positive_regulation of Ptgs2 1 0.05 1.07 0.34
77 INT134303 Cpox Negative_regulation of PTGS2 1 0.00 0.77 0.34
78 INT89502 Positive_regulation of Nos2 Positive_regulation of Ptgs2 1 0.05 1.07 0.34
79 INT194859 IL1B Positive_regulation of Gene_expression of MMP13 2 0.52 0.86 0.33
80 INT143567 Edn1 Regulation of Ptgs2 1 0.26 0.17 0.33
81 INT323870 LEP Regulation of Gene_expression of MMP13 1 0.21 1.76 0.33
82 INT311997 Regulation of STAM Regulation of BGLAP 1 0.00 0.61 0.32
83 INT52700 Prkcg Positive_regulation of Ptgs2 1 0.12 0.3 0.32
84 INT142947 Binding of ERCC2 and OPRM1 1 0.05 0.3 0.32
85 INT108879 Negative_regulation of PTGS2 Positive_regulation of Protein_catabolism of Nfkbia 1 0.00 0.43 0.31
86 INT224687 Il1 Positive_regulation of Bmp2 1 0.00 0.3 0.31
87 INT311991 STAM Regulation of BGLAP 1 0.00 0.61 0.31
88 INT64859 Negative_regulation of PTGS1 Negative_regulation of PTGS2 1 0.07 0.05 0.31
89 INT116594 Negative_regulation of PTGS2 Negative_regulation of Gene_expression of IL6 1 0.22 0.45 0.31
90 INT139044 AKR1B1 Regulation of Gene_expression of PTGS2 1 0.09 0.37 0.3
91 INT166165 Binding of TGFB3 and Bmp2 1 0.00 0 0.3
92 INT156084 Binding of PTGS2 and AKR1C3 1 0.02 0.31 0.3
93 INT62207 Binding of PTGS1 and PTGS2 3 0.06 0.07 0.29
94 INT265467 HRAS Negative_regulation of Gene_expression of PTGS2 1 0.01 0.84 0.29
95 INT328224 Col2a1 Positive_regulation of Gene_expression of Mmp13 1 0.04 0.8 0.29
96 INT328223 Mmp14 Regulation of Positive_regulation of Mmp13 1 0.07 0.69 0.29
97 INT243214 Myst2 Negative_regulation of Gene_expression of Ptgs2 1 0.01 1.4 0.28
98 INT336335 Glp2r Regulation of Mmp13 1 0.06 0.68 0.28
99 INT328222 Mmp2 Regulation of Positive_regulation of Mmp13 1 0.05 0.69 0.28
100 INT91751 Binding of PTGS2 and Hmox1 1 0.00 0.21 0.27
101 INT233781 Binding of PTH1R and SCT 1 0.18 0 0.27
102 INT142447 PTGS2 Regulation of Gene_expression of PTGIS 1 0.30 0.24 0.27
103 INT107392 PTGS2 Positive_regulation of PTGS1 2 0.31 1.01 0.26
104 INT114069 Negative_regulation of Agtr2 Positive_regulation of Ptgs2 1 0.08 0.49 0.26
105 INT69120 MOCS1 Regulation of PTGS2 1 0.00 0.39 0.26
106 INT96402 Binding of PTGS2 and TBXAS1 1 0.02 0.32 0.26
107 INT64860 PTGS1 Negative_regulation of PTGS2 1 0.07 0 0.26
108 INT96401 Binding of PTGER1 and PTGS2 1 0.00 0.32 0.26
109 INT335126 Ptgs2 Positive_regulation of Gene_expression of PPARA 1 0.24 0.72 0.25
110 INT180964 PLG Positive_regulation of MMP13 1 0.24 0.45 0.25
111 INT102625 IL6 Regulation of Gene_expression of PTGS2 1 0.11 0.29 0.24
112 INT130691 CA2 Positive_regulation of EIF2AK3 1 0.16 0.59 0.24
113 INT136798 Spp1 Regulation of Gene_expression of PTGS2 1 0.08 0.65 0.24
114 INT126552 Agt Positive_regulation of Gene_expression of Ptgs2 1 0.32 0.92 0.24
115 INT166663 Mpzl2 Negative_regulation of Positive_regulation of Ptgs2 1 0.29 0.3 0.24
116 INT102617 PTAFR Regulation of Gene_expression of PTGS2 1 0.12 0.29 0.24
117 INT132382 Nos2 Positive_regulation of PTGS2 1 0.02 0.1 0.23
118 INT272143 PTAFR Positive_regulation of Gene_expression of PTGS2 1 0.12 1.59 0.23
119 INT311911 Tgfbr1 Positive_regulation of Gene_expression of Mmp13 1 0.10 0.55 0.23
120 INT311908 Acvrl1 Positive_regulation of Gene_expression of Mmp13 1 0.10 0.55 0.23
121 INT126549 Agt Positive_regulation of Ptgs2 1 0.32 0.9 0.23
122 INT260835 NRP2 Positive_regulation of Eif2ak3 1 0.00 0.73 0.23
123 INT182272 EDN1 Regulation of Gene_expression of MMP13 1 0.26 0.87 0.22
124 INT145014 Positive_regulation of GAST Positive_regulation of PTGS2 1 0.31 0.51 0.22
125 INT264526 PTGDS Negative_regulation of Gene_expression of MMP13 1 0.12 0.5 0.22
126 INT133164 Ptgs2 Regulation of Tnf 1 0.14 0.98 0.22
127 INT207456 LGALS3 Negative_regulation of Gene_expression of BGLAP 1 0.13 0.5 0.22
128 INT145012 GAST Positive_regulation of PTGS2 1 0.42 0.51 0.22
129 INT112134 Gast Positive_regulation of Gene_expression of Ptgs2 1 0.28 0.19 0.21
130 INT69318 ST3GAL4 Positive_regulation of Gene_expression of PTGS2 1 0.35 0.09 0.21
131 INT112136 Egf Positive_regulation of Gene_expression of Ptgs2 1 0.21 0.19 0.21
132 INT254687 Positive_regulation of Map2k1 Positive_regulation of Gene_expression of Mmp13 1 0.06 0.2 0.2
133 INT283747 Tbs1 Positive_regulation of Ptgs2 1 0.00 0 0.2
134 INT244299 FFAR1 Positive_regulation of PTH1R 1 0.00 0.4 0.2
135 INT231639 Binding of PTGER2 and PTGS2 1 0.00 0.44 0.19
136 INT117517 PROC Positive_regulation of PTGS2 1 0.01 0.61 0.19
137 INT182271 EDN1 Positive_regulation of Localization of MMP13 1 0.27 0.47 0.19
138 INT79651 PTGS2 Positive_regulation of Phosphorylation of NR3C1 1 0.07 0.1 0.19
139 INT206089 Negative_regulation of FOSB Negative_regulation of Gene_expression of PTGS2 1 0.00 0.97 0.19
140 INT139015 STAT1 Negative_regulation of Gene_expression of PTGS2 1 0.01 0.36 0.19
141 INT287014 Gabrd Regulation of Ptn 1 0.10 0 0.18
142 INT73332 IL1B Positive_regulation of Transcription of PTGS2 1 0.44 0.54 0.18
143 INT111152 Pthlh Positive_regulation of Localization of Avp 1 0.53 0.26 0.18
144 INT73331 PTAFR Positive_regulation of Transcription of PTGS2 1 0.13 0.54 0.18
145 INT119130 Binding of Nos2 and Ptgs2 1 0.33 0.07 0.17
146 INT354819 Binding of Cpox and Ptgs2 1 0.02 0.45 0.16
147 INT69317 PTGS2 Positive_regulation of Gene_expression of PTGS1 1 0.42 0.09 0.16
148 INT141753 Nfkb1 Regulation of Ptgs2 1 0.16 1.18 0.16
149 INT146745 UGCG Positive_regulation of Gene_expression of PTGS2 1 0.23 0.1 0.16
150 INT141754 Nfkb1 Regulation of Positive_regulation of Ptgs2 1 0.16 1.21 0.16
151 INT176621 PTGS2 Regulation of Gene_expression of PTGER2 1 0.00 0.09 0.15
152 INT87710 MYB Regulation of PTGS2 1 0.28 0.64 0.15
153 INT92342 Zfp697 Negative_regulation of Ptgs2 1 0.02 0.63 0.15
154 INT138321 PPA1 Positive_regulation of Gene_expression of PTGS2 1 0.02 0.09 0.14
155 INT107889 Binding of Pthlh and Pth1r 1 0.06 0 0.14
156 INT141111 Sftpa1 Positive_regulation of Ptgs2 1 0.64 0.3 0.14
157 INT328851 Binding of PTGS2 and ZNF434 1 0.00 0.7 0.14
158 INT141112 Negative_regulation of Sftpa1 Positive_regulation of Ptgs2 1 0.39 0.31 0.14
159 INT220213 Mmp13 Regulation of Protein_catabolism of COL2A1 1 0.49 0.29 0.14
160 INT107892 Binding of Pthlh and PTH2 1 0.27 0 0.14
161 INT103557 Binding of ERCC2 and TP53 1 0.40 1 0.13
162 INT81983 IL1A Positive_regulation of Positive_regulation of PTGS2 1 0.01 0.27 0.13
163 INT264399 Binding of IL1B and MMP13 1 0.39 0.08 0.13
164 INT306270 CCL4 Positive_regulation of Transcription of PTGS2 1 0.34 0.31 0.12
165 INT311912 Gene_expression of Smad1 Positive_regulation of Gene_expression of Mmp13 1 0.08 0.51 0.12
166 INT264397 MMP9 Regulation of Positive_regulation of MMP13 1 0.20 0.06 0.12
167 INT264389 MMP14 Regulation of Positive_regulation of MMP13 1 0.31 0.06 0.12
168 INT173129 PTGS2 Regulation of IER3 1 0.01 0.36 0.12
169 INT306262 NFKB1 Positive_regulation of Transcription of PTGS2 1 0.42 0.31 0.12
170 INT63521 Negative_regulation of Ptgs2 Negative_regulation of Gene_expression of Fos 1 0.66 0.1 0.12
171 INT264381 MMP3 Regulation of Positive_regulation of MMP13 1 0.21 0.06 0.12
172 INT323886 BMI1 Regulation of Gene_expression of MMP13 1 0.01 1.13 0.12
173 INT117568 Dspp Negative_regulation of Ptgs2 1 0.11 0.13 0.12
174 INT346530 Binding of PTH1R and TFIP11 1 0.15 0 0.11
175 INT147073 NFKB1 Regulation of PTGS2 1 0.37 0 0.11
176 INT133361 FABP6 Negative_regulation of PTGS2 1 0.01 0.07 0.11
177 INT52701 Slc3a1 Positive_regulation of Ptgs2 1 0.06 0.27 0.11
178 INT323882 Binding of BMI1 and MMP13 1 0.01 1.26 0.11
179 INT52702 Capza2 Positive_regulation of Ptgs2 1 0.00 0.27 0.11
180 INT294454 KLK4 Negative_regulation of PTGS2 1 0.01 0 0.1
181 INT87922 Gm7869 Negative_regulation of Ptgs2 1 0.01 0.56 0.1
182 INT346526 Binding of ADORA1 and PTH1R 1 0.01 0 0.1
183 INT327557 Pla2g4a Positive_regulation of Phosphorylation of Ptgs2 1 0.14 1.03 0.1
184 INT309780 Binding of PTH and PTH1R 3 0.12 0.3 0.09
185 INT327559 Pla2g4a Positive_regulation of Gene_expression of Ptgs2 1 0.14 1 0.09
186 INT215884 Eif2ak3 Positive_regulation of Gene_expression of Musd1 1 0.01 0.96 0.09
187 INT311917 Gene_expression of Tgfbr1 Positive_regulation of Gene_expression of Mmp13 1 0.10 0.31 0.08
188 INT268325 Lep Positive_regulation of Ptgs2 1 0.09 0.39 0.08
189 INT303561 Binding of Fgf7 and Fgfr2 1 0.42 0.88 0.07
190 INT140895 PTGS2 Positive_regulation of Gene_expression of VEGFA 1 0.27 0.07 0.07
191 INT343157 ACSL4 Regulation of Gene_expression of ALOX15 1 0.01 0.67 0.07
192 INT98715 HGF Positive_regulation of Gene_expression of PTGS2 1 0.02 1.03 0.07
193 INT215874 Positive_regulation of Eif2ak3 Positive_regulation of Positive_regulation of Ddit3 1 0.47 0.31 0.07
194 INT138133 Nfkb1 Regulation of Positive_regulation of Mmp13 1 0.00 0.31 0.07
195 INT303560 Binding of Fgfr2 and Fgf22 1 0.41 0.89 0.07
196 INT303562 Binding of Fgf10 and Fgfr2 1 0.40 0.88 0.07
197 INT311915 Tgfbr1 Negative_regulation of Gene_expression of Mmp13 1 0.09 0.27 0.06
198 INT295122 Bmp2 Regulation of Grxcr1 1 0.02 0.66 0.06
199 INT215883 Eif2ak3 Regulation of Musd1 1 0.00 0.8 0.06
200 INT311903 Acvrl1 Negative_regulation of Gene_expression of Mmp13 1 0.09 0.27 0.06

Single Events

The table below shows the top 100 pain related interactions that have been reported for bone mineralization. They are ordered first by their pain relevance and then by number of times they were reported in bone mineralization. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT34869 Negative_regulation of PTGS2 778 0.59 366.76 319.85
2 INT50674 Gene_expression of PTGS2 459 0.78 253.33 118.51
3 INT15613 Negative_regulation of Ptgs2 160 0.59 71.08 65.08
4 INT39153 Positive_regulation of PTGS2 182 0.70 96.16 60.6
5 INT52692 Gene_expression of Ptgs2 160 0.78 85.06 55.73
6 INT52611 Negative_regulation of Ptgs2 142 0.59 66.31 52.71
7 INT53083 Gene_expression of Ptgs2 153 0.78 90.04 50.39
8 INT55135 Positive_regulation of Gene_expression of PTGS2 137 0.70 80.32 38.46
9 INT52690 Positive_regulation of Ptgs2 65 0.68 39.51 30.02
10 INT129956 Gene_expression of MMP13 145 0.72 60.48 26.98
11 INT50490 Regulation of PTGS2 80 0.48 39.51 25.85
12 INT52693 Positive_regulation of Gene_expression of Ptgs2 57 0.70 25.51 21.18
13 INT17848 Binding of PTGS2 70 0.46 32.1 20.6
14 INT116282 Gene_expression of Mmp13 83 0.75 45.4 20.18
15 INT1284 Negative_regulation of Mmp13 20 0.57 36.21 14.91
16 INT109031 Positive_regulation of Eif2ak3 44 0.69 21.11 14.72
17 INT52696 Positive_regulation of Ptgs2 48 0.70 27.65 14.44
18 INT109034 Gene_expression of Eif2ak3 37 0.77 17.11 14.19
19 INT123779 Positive_regulation of MMP13 42 0.65 24.3 12.45
20 INT59080 Negative_regulation of Gene_expression of PTGS2 55 0.58 22.92 12.39
21 INT53082 Positive_regulation of Gene_expression of Ptgs2 47 0.64 25.39 11.39
22 INT6515 Gene_expression of BGLAP 110 0.75 45.13 10.81
23 INT52689 Regulation of Ptgs2 27 0.60 12.76 10.6
24 INT53081 Negative_regulation of Gene_expression of Ptgs2 29 0.59 15.83 10.39
25 INT85535 Negative_regulation of Gene_expression of Ptgs2 27 0.51 16.04 10.01
26 INT6516 Positive_regulation of BGLAP 45 0.67 26.61 9.9
27 INT140191 Positive_regulation of Gene_expression of Mmp13 25 0.67 13.47 9.71
28 INT69321 Regulation of Gene_expression of PTGS2 27 0.61 13.27 9.53
29 INT150678 Positive_regulation of Gene_expression of Eif2ak3 17 0.69 6.64 8.99
30 INT129962 Positive_regulation of Gene_expression of MMP13 41 0.65 20.74 8.54
31 INT17250 Negative_regulation of BGLAP 35 0.57 21 8.26
32 INT52688 Transcription of Ptgs2 16 0.69 8.31 7.52
33 INT50669 Negative_regulation of Ptn 15 0.58 5.56 6.88
34 INT90097 Localization of PTGS2 15 0.69 6.14 6.63
35 INT59079 Transcription of PTGS2 30 0.72 14.21 6.52
36 INT6052 Gene_expression of Ptn 12 0.78 8.4 6.5
37 INT71002 Gene_expression of ALOX15 21 0.78 21.16 6.37
38 INT168383 Positive_regulation of Mmp13 27 0.67 17.9 6.27
39 INT93079 Positive_regulation of ALOX15 8 0.70 12.46 6.22
40 INT67656 Positive_regulation of Positive_regulation of PTGS2 12 0.46 4.83 6.17
41 INT233812 Gene_expression of PTH1R 32 0.77 18.15 6.15
42 INT36757 Gene_expression of Eif2ak3 4 0.74 0.15 6.06
43 INT78955 Regulation of Gene_expression of Ptgs2 12 0.62 7.22 6.02
44 INT18523 Negative_regulation of ALOX15 15 0.59 14.2 5.92
45 INT112530 Localization of Ptgs2 13 0.70 7.77 5.86
46 INT12564 Localization of Pthlh 23 0.81 4.37 5.82
47 INT52695 Regulation of Ptgs2 20 0.42 8.72 5.71
48 INT141146 Gene_expression of Mmp13 18 0.38 8.61 5.54
49 INT103899 Gene_expression of ERCC2 14 0.65 7.85 5.49
50 INT4864 Regulation of BGLAP 22 0.34 10.8 5.07
51 INT1285 Localization of Mmp13 12 0.78 8.98 4.93
52 INT137336 Phosphorylation of Eif2ak3 14 0.79 4.72 4.78
53 INT68260 Localization of BGLAP 34 0.78 16.04 4.63
54 INT73309 Regulation of Negative_regulation of PTGS2 14 0.44 9.55 4.5
55 INT129964 Negative_regulation of MMP13 23 0.55 6.48 4.21
56 INT52616 Negative_regulation of Positive_regulation of PTGS2 13 0.43 4.95 4.13
57 INT5602 Positive_regulation of Eif2ak3 9 0.66 0 4.04
58 INT6513 Positive_regulation of Gene_expression of BGLAP 24 0.67 11.69 3.96
59 INT115773 Negative_regulation of Localization of Ptgs2 6 0.43 2.99 3.81
60 INT89606 Positive_regulation of Gene_expression of ALOX15 9 0.70 8.34 3.76
61 INT13416 Positive_regulation of Pthlh 19 0.60 14.78 3.74
62 INT149614 Localization of MMP13 13 0.81 6.12 3.65
63 INT32464 Regulation of Mmp13 12 0.44 6.46 3.61
64 INT129960 Negative_regulation of Gene_expression of MMP13 19 0.53 7.17 3.55
65 INT53200 Binding of Ptgs2 11 0.48 5.08 3.54
66 INT236824 Negative_regulation of Gene_expression of PTH1R 10 0.58 9.3 3.42
67 INT116281 Negative_regulation of Gene_expression of Mmp13 15 0.41 9.96 3.41
68 INT52694 Negative_regulation of Positive_regulation of Ptgs2 9 0.43 4.72 3.11
69 INT91341 Negative_regulation of Gene_expression of BGLAP 17 0.55 4.91 3.02
70 INT96423 Gene_expression of Bmp2 61 0.78 25.07 3.01
71 INT91342 Negative_regulation of Negative_regulation of BGLAP 2 0.55 1.39 2.88
72 INT68505 Positive_regulation of Negative_regulation of PTGS2 8 0.49 2.26 2.76
73 INT127176 Transcription of Ptgs2 8 0.58 4.68 2.58
74 INT203819 Binding of Eif2ak3 9 0.37 5.94 2.57
75 INT15695 Positive_regulation of EIF2AK3 12 0.67 7.01 2.56
76 INT172592 Positive_regulation of PTH1R 9 0.28 6.25 2.5
77 INT140525 Regulation of Gene_expression of Ptn 4 0.62 2.59 2.49
78 INT17846 Binding of Ptgs2 8 0.32 4.66 2.48
79 INT78958 Regulation of Negative_regulation of Ptgs2 6 0.42 2.61 2.3
80 INT36758 Positive_regulation of Gene_expression of Eif2ak3 1 0.48 0 2.21
81 INT12565 Regulation of Localization of Pthlh 10 0.62 0.71 2.14
82 INT91340 Regulation of Localization of BGLAP 5 0.58 2.82 2.14
83 INT120106 Negative_regulation of Mmp13 8 0.51 2.25 2.08
84 INT116280 Transcription of Mmp13 11 0.67 6.52 2.06
85 INT145235 Protein_catabolism of Mmp13 3 0.89 2.46 2.03
86 INT186893 Binding of BGLAP 10 0.37 6.19 2.02
87 INT97579 Negative_regulation of Localization of PTGS2 2 0.08 2.37 1.99
88 INT36755 Positive_regulation of Localization of Eif2ak3 1 0.48 0 1.97
89 INT36756 Localization of Eif2ak3 1 0.71 0 1.96
90 INT9015 Positive_regulation of Ptn 6 0.69 3 1.94
91 INT150675 Regulation of Gene_expression of Eif2ak3 3 0.40 1.11 1.93
92 INT77805 Regulation of Gene_expression of Ptgs2 6 0.51 2.7 1.92
93 INT52691 Positive_regulation of Transcription of Ptgs2 5 0.44 3 1.9
94 INT13861 Negative_regulation of Localization of Pthlh 2 0.10 0.08 1.81
95 INT103900 Positive_regulation of ERCC2 7 0.58 3.47 1.78
96 INT182295 Regulation of MMP13 6 0.27 3.33 1.77
97 INT36759 Regulation of Gene_expression of Eif2ak3 1 0.59 0 1.74
98 INT101257 Negative_regulation of Positive_regulation of ALOX15 1 0.41 1.47 1.71
99 INT46530 Gene_expression of Pthlh 15 0.78 11.23 1.7
100 INT135984 Regulation of Ptn 3 0.44 2.07 1.67
101 INT12566 Positive_regulation of Localization of Pthlh 4 0.70 0.13 1.65
102 INT141147 Negative_regulation of Gene_expression of Mmp13 5 0.12 1.37 1.59
103 INT109033 Positive_regulation of Positive_regulation of Eif2ak3 2 0.45 2.36 1.59
104 INT39997 Negative_regulation of Gla 8 0.59 6.38 1.51
105 INT72138 Gene_expression of Pthlh 18 0.75 17.68 1.49
106 INT120111 Regulation of Mmp13 4 0.29 2.65 1.48
107 INT150677 Negative_regulation of Eif2ak3 9 0.58 6.24 1.46
108 INT149622 Positive_regulation of Transcription of Ptgs2 3 0.28 2.48 1.46
109 INT126635 Negative_regulation of Alox15 2 0.41 0.67 1.43
110 INT190768 Regulation of Positive_regulation of Ptgs2 1 0.04 1.2 1.41
111 INT86823 Regulation of Transcription of PTGS2 3 0.19 1.48 1.4
112 INT129963 Regulation of Gene_expression of MMP13 8 0.42 2.84 1.39
113 INT148740 Regulation of Gene_expression of Mmp13 1 0.03 2.58 1.37
114 INT215864 Localization of Eif2ak3 5 0.75 3.26 1.36
115 INT18337 Transcription of Eif2ak3 3 0.68 0 1.36
116 INT123778 Positive_regulation of Positive_regulation of MMP13 4 0.25 2.51 1.34
117 INT135658 Phosphorylation of Ptgs2 2 0.23 1.39 1.34
118 INT70619 Regulation of Bmp2 6 0.60 3.1 1.29
119 INT170294 Regulation of Gene_expression of Mmp13 5 0.44 4.25 1.26
120 INT101026 Positive_regulation of Negative_regulation of Ptgs2 2 0.35 1.01 1.23
121 INT127900 Phosphorylation of EIF2AK3 14 0.80 7.99 1.22
122 INT120108 Transcription of Mmp13 3 0.51 0.22 1.22
123 INT317972 Positive_regulation of Transcription of Mmp13 5 0.41 3.83 1.21
124 INT179372 Positive_regulation of Localization of PTGS2 2 0.38 0.35 1.21
125 INT150763 Negative_regulation of Gene_expression of Ptn 1 0.43 2.36 1.2
126 INT59078 Positive_regulation of Transcription of PTGS2 5 0.69 2.36 1.17
127 INT142950 Protein_catabolism of ERCC2 2 0.25 1.45 1.14
128 INT96424 Transcription of Bmp2 6 0.69 6.34 1.11
129 INT62981 Protein_catabolism of PTGS2 5 0.78 1.09 1.11
130 INT220926 Transcription of MMP13 12 0.67 3.03 1.09
131 INT170321 Binding of Mmp13 3 0.36 2.54 1.09
132 INT64862 Negative_regulation of Negative_regulation of PTGS2 3 0.36 0.76 1.09
133 INT76890 Gene_expression of FGFR2 42 0.65 13.91 1.08
134 INT70505 Positive_regulation of Positive_regulation of Ptgs2 4 0.49 2.22 1.08
135 INT121792 Gene_expression of PTN 13 0.75 2.81 1.07
136 INT137338 Regulation of Eif2ak3 8 0.45 5.5 1.07
137 INT160538 Binding of Bmp2 4 0.40 2.08 1.07
138 INT233816 Negative_regulation of PTH1R 2 0.58 4.08 1.07
139 INT83647 Negative_regulation of Negative_regulation of Ptgs2 1 0.28 1.97 1.05
140 INT64177 Negative_regulation of Transcription of PTGS2 4 0.41 1.99 1.03
141 INT101256 Regulation of ALOX15 3 0.26 2.44 1.02
142 INT173552 Protein_catabolism of Mmp13 5 0.96 3.05 1.01
143 INT316724 Negative_regulation of Localization of Mmp13 1 0.13 0.63 1
144 INT130005 Protein_catabolism of MMP13 4 0.36 3.02 0.95
145 INT68265 Positive_regulation of Negative_regulation of Ptgs2 3 0.46 0.08 0.92
146 INT309781 Positive_regulation of Gene_expression of PTH1R 2 0.46 1.88 0.87
147 INT240368 Positive_regulation of Localization of Eif2ak3 1 0.34 0.66 0.87
148 INT224483 Regulation of Regulation of MMP13 2 0.15 1.16 0.86
149 INT338119 Negative_regulation of Transcription of Mmp13 1 0.09 0 0.86
150 INT109032 Negative_regulation of Positive_regulation of Eif2ak3 1 0.38 0.94 0.85
151 INT183182 Negative_regulation of FGFR2 2 0.29 1.25 0.84
152 INT149624 Regulation of Transcription of Ptgs2 1 0.16 0.84 0.84
153 INT127899 Gene_expression of EIF2AK3 8 0.75 2.89 0.8
154 INT115770 Negative_regulation of Positive_regulation of Ptgs2 4 0.43 0.94 0.79
155 INT154053 Negative_regulation of Gene_expression of Eif2ak3 2 0.43 1.28 0.79
156 INT120057 Regulation of Localization of PTGS2 1 0.28 0.14 0.78
157 INT127901 Positive_regulation of Gene_expression of EIF2AK3 3 0.49 1.8 0.77
158 INT312011 Negative_regulation of Binding of BGLAP 1 0.11 1.04 0.76
159 INT71950 Positive_regulation of Binding of PTGS2 2 0.31 0.31 0.74
160 INT78957 Regulation of Transcription of Ptgs2 1 0.17 0.49 0.72
161 INT82544 Regulation of Positive_regulation of PTGS2 4 0.39 1.41 0.71
162 INT127175 Negative_regulation of Transcription of Ptgs2 3 0.47 2.11 0.7
163 INT39999 Gene_expression of Gla 7 0.59 3.27 0.69
164 INT89607 Negative_regulation of Negative_regulation of ALOX15 3 0.43 2.08 0.68
165 INT127898 Positive_regulation of Phosphorylation of EIF2AK3 3 0.49 2.03 0.67
166 INT244300 Localization of PTH1R 2 0.74 2.03 0.67
167 INT150761 Positive_regulation of Gene_expression of Ptn 1 0.69 1.39 0.67
168 INT35705 Regulation of CYP27B1 1 0.23 0 0.66
169 INT92341 Localization of Ptgs2 5 0.75 2.04 0.64
170 INT120113 Positive_regulation of Mmp13 5 0.70 2.02 0.64
171 INT305480 Regulation of Protein_catabolism of Mmp13 1 0.29 0.73 0.64
172 INT158136 Binding of FGFR2 9 0.26 4.5 0.63
173 INT80452 Positive_regulation of Gene_expression of Pthlh 4 0.40 3.77 0.62
174 INT89605 Negative_regulation of Gene_expression of ALOX15 8 0.59 4.03 0.61
175 INT235398 Regulation of Gene_expression of BGLAP 3 0.27 1.03 0.61
176 INT209948 Gene_expression of CLEC3B 3 0.78 11.51 0.6
177 INT274679 Regulation of Negative_regulation of Mmp13 2 0.43 1.78 0.57
178 INT30943 Negative_regulation of Pthlh 3 0.20 2.75 0.56
179 INT115772 Positive_regulation of Localization of Ptgs2 1 0.46 0.5 0.55
180 INT145999 Binding of Ptn 1 0.18 0 0.55
181 INT115771 Positive_regulation of Positive_regulation of Ptgs2 1 0.46 0.5 0.54
182 INT37359 Negative_regulation of PTN 4 0.32 1.58 0.53
183 INT5601 Regulation of Eif2ak3 1 0.43 0 0.53
184 INT50555 Regulation of Pthlh 3 0.16 2.07 0.52
185 INT134070 Binding of ERCC2 3 0.27 0.76 0.51
186 INT81175 Localization of Pthlh 4 0.70 7.64 0.5
187 INT142835 Regulation of Localization of Ptgs2 2 0.25 0.26 0.5
188 INT18336 Positive_regulation of Positive_regulation of Eif2ak3 1 0.33 0 0.49
189 INT146778 Negative_regulation of Fgfr2 1 0.32 0.66 0.48
190 INT145301 Regulation of Gene_expression of Bmp2 1 0.32 1.16 0.48
191 INT277472 Positive_regulation of PTN 4 0.49 1.14 0.46
192 INT224428 Positive_regulation of Localization of BGLAP 5 0.30 2.34 0.44
193 INT120086 Gene_expression of Bmp2 5 0.27 2.34 0.43
194 INT94036 Negative_regulation of Transcription of Ptgs2 1 0.30 0.52 0.43
195 INT202626 Negative_regulation of Fgfr2 2 0.41 2.48 0.42
196 INT5009 Positive_regulation of Negative_regulation of Mmp13 1 0.06 0.1 0.42
197 INT88678 Gene_expression of CYP27B1 8 0.75 2.11 0.41
198 INT218020 Positive_regulation of CYP27B1 3 0.49 0.15 0.41
199 INT103901 Regulation of ERCC2 1 0.23 0.51 0.4
200 INT235063 Positive_regulation of Gene_expression of Gla 2 0.04 0.81 0.39
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