GO:0030284

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Name estrogen receptor activity
Categary Function
Go Slim No
Go Link GO:0030284
Unique Molecular Interactions 531
Total Molecular Interactions 662
Total Single Events 6878
Pain Genes Associated 12

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for estrogen receptor activity. They are ordered first by their pain relevance and then by number of times they were reported for estrogen receptor activity. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT108810 Esr1 Positive_regulation of Binding of Oprm1 1 0.51 1.79 3.22
2 INT158079 Binding of Esr1 and Gper 1 0.31 0.97 1.35
3 INT222182 Binding of ESR1 and HLA-DRB2 1 0.00 3.1 1.35
4 INT150890 Binding of Esr1 and Esr2 2 0.52 2.06 1.31
5 INT150835 Gper Positive_regulation of Localization of Prkce 1 0.15 0.62 1.18
6 INT278292 Binding of CRP and ESR1 6 0.09 10.92 0.96
7 INT278690 LEF1 Negative_regulation of Gene_expression of IK 1 0.00 0.66 0.83
8 INT108811 Esr2 Positive_regulation of Binding of Oprm1 1 0.46 0.44 0.79
9 INT278697 LEF1 Negative_regulation of STAT6 1 0.00 0.44 0.78
10 INT108812 Esr1 Positive_regulation of Positive_regulation of Oprm1 1 0.42 0.38 0.78
11 INT291548 Binding of Gper and Sec22b 1 0.02 0.94 0.67
12 INT38057 Binding of Crp and Esr1 2 0.04 1.21 0.65
13 INT309158 Binding of Esr1 and Dlat 1 0.04 1.39 0.61
14 INT109802 Binding of Esr2 and Oprl1 1 0.22 0.1 0.59
15 INT341594 Binding of ESR1 and HLA-B 1 0.01 0.72 0.57
16 INT150833 Esr1 Positive_regulation of Localization of Prkce 1 0.08 0.29 0.51
17 INT291556 Binding of ESR1 and Sec22b 2 0.00 0.86 0.5
18 INT154014 Binding of Esr1 and Gabrg1 1 0.07 0.07 0.5
19 INT147179 Esr1 Regulation of Gene_expression of Penk 1 0.01 0.68 0.46
20 INT323840 Binding of Esr1 and Il1 1 0.04 0.9 0.42
21 INT261374 Nsdhl Regulation of Esr2 1 0.05 0.76 0.41
22 INT261370 Nsdhl Regulation of Esr1 1 0.01 0.75 0.41
23 INT346151 Binding of ADM and GPER 1 0.01 0.99 0.41
24 INT264522 Binding of GPER and PTGDS 1 0.03 1.22 0.4
25 INT117361 Binding of Esr1 and sea 1 0.02 1.38 0.38
26 INT199974 ESR1 Negative_regulation of Gene_expression of ITGB3BP 1 0.05 0.47 0.38
27 INT197591 Esr1 Regulation of Pgr 1 0.04 0 0.38
28 INT117359 Binding of Esr1 and Wbc1 1 0.00 1.38 0.37
29 INT245328 Binding of Esr2 and Pgr 1 0.03 0.41 0.37
30 INT291555 Binding of ESR1 and Dlat 1 0.01 0.6 0.35
31 INT291554 Binding of ESR1 and St8sia2 1 0.01 0.49 0.33
32 INT291543 Binding of Dlat and Gper 1 0.15 0.37 0.33
33 INT350214 Binding of GPER and HSPG2 1 0.00 0.12 0.32
34 INT128756 Binding of Esr1 and Foxc1 1 0.01 0.43 0.32
35 INT309156 Esr1 Regulation of Gene_expression of Dlat 1 0.05 1.06 0.3
36 INT222301 Binding of ERBB2 and ESR1 5 0.36 5.07 0.29
37 INT158734 Esr1 Regulation of Esrrb 1 0.00 0.28 0.29
38 INT158733 Esr1 Regulation of Plxna3 1 0.03 0.27 0.29
39 INT185092 CRP Positive_regulation of ESR1 1 0.06 2.83 0.28
40 INT199978 ESR1 Regulation of ITGB3BP 1 0.03 0.39 0.28
41 INT71904 Binding of ESR1 and PGR 6 0.34 3.79 0.27
42 INT323152 Binding of DBT and ESR1 2 0.02 1.29 0.27
43 INT346195 AMELX Negative_regulation of ESR1 1 0.02 0.36 0.26
44 INT263587 Pdia3 Negative_regulation of Binding of Esr1 1 0.07 1.86 0.26
45 INT186783 Binding of ESR1 and NRIP1 1 0.31 0.79 0.25
46 INT199970 CYP19A1 Positive_regulation of Gene_expression of ESR1 1 0.06 0.72 0.25
47 INT182346 Binding of Cd3e and Esr1 1 0.06 1.26 0.25
48 INT182349 Binding of Ms4a1 and Esr1 1 0.04 1.26 0.25
49 INT199971 IL6 Positive_regulation of ESR1 1 0.08 0.84 0.24
50 INT309160 Binding of Esr1 and Edc4 1 0.03 0.34 0.24
51 INT197590 Esr2 Positive_regulation of Negative_regulation of Pgr 1 0.16 0 0.24
52 INT159163 Binding of Esr2 and Regulation of Gper 1 0.41 0.27 0.23
53 INT63203 INS Positive_regulation of ESR1 1 0.09 0.3 0.23
54 INT261389 Nsdhl Positive_regulation of Esr2 1 0.06 1.04 0.23
55 INT63198 POMC Positive_regulation of ESR1 1 0.14 0.3 0.23
56 INT270135 Binding of ESR1 and RALA 1 0.11 0.37 0.22
57 INT63192 PTH Positive_regulation of ESR1 1 0.20 0.29 0.22
58 INT308645 Binding of Esr1 and Itpr3 1 0.00 0 0.2
59 INT351086 Negative_regulation of ERBB2 Positive_regulation of Gene_expression of ESR1 1 0.10 0.75 0.19
60 INT351089 FOXO3 Positive_regulation of Gene_expression of ESR1 1 0.04 0.74 0.19
61 INT192219 CASP3 Regulation of ESR1 1 0.03 1.19 0.19
62 INT197618 Binding of Esr1 and Ppt1 1 0.01 0 0.18
63 INT173932 Binding of Esr1 and Il6 1 0.03 0.11 0.18
64 INT339336 Binding of NKX3-1 and TAC4 1 0.03 0.08 0.18
65 INT19042 ESR1 Positive_regulation of GGT5 1 0.03 0.6 0.17
66 INT19045 ESR1 Positive_regulation of Salpa1 1 0.02 0.6 0.17
67 INT309154 Esr1 Positive_regulation of Gsdmc 1 0.01 0.44 0.15
68 INT266036 Gpr30 Positive_regulation of Positive_regulation of Mapk1 1 0.19 0.24 0.15
69 INT309155 Negative_regulation of Esr1 Positive_regulation of Gsdmc 1 0.01 0.45 0.15
70 INT181752 Binding of CPOX and ESR1 1 0.02 0.89 0.14
71 INT291644 Binding of DST and ESR1 1 0.05 0.84 0.14
72 INT173404 GPER Regulation of Itgam 1 0.02 0.41 0.13
73 INT297312 Esr1 Positive_regulation of Scap 1 0.00 1.58 0.13
74 INT267973 Binding of CHKB and ESR1 1 0.02 1.67 0.13
75 INT86429 Binding of Hspb1 and Esr1 1 0.19 0.26 0.13
76 INT173373 GPER Regulation of FCGR3B 1 0.03 0.39 0.12
77 INT236588 Binding of Esr1 and Ins1 1 0.05 0.73 0.12
78 INT171792 GPER Regulation of Gene_expression of Itga2 1 0.00 0.54 0.12
79 INT341827 Binding of ESR1 and TNC 1 0.14 0.63 0.11
80 INT341775 DBT Regulation of Binding of ESR1 1 0.02 0.1 0.11
81 INT252779 Binding of ESR1 and RAF1 1 0.01 2.03 0.11
82 INT171791 GPER Negative_regulation of Gene_expression of Itgam 1 0.02 0.46 0.11
83 INT220114 Tnfrsf1a Positive_regulation of Esr1 1 0.14 1.14 0.1
84 INT237819 Binding of Esr1 and soc 1 0.04 0 0.1
85 INT279407 Binding of ESR1 and IGKV2-19 1 0.02 0.4 0.1
86 INT125000 Binding of Esr1 and Tas2r108 1 0.04 0.33 0.1
87 INT237812 Esr1 Positive_regulation of Positive_regulation of soc 1 0.05 0.6 0.1
88 INT201747 Itpr3 Positive_regulation of Localization of Esr1 2 0.03 1.19 0.09
89 INT308662 Binding of Esr1 and Fdft1 1 0.00 0.05 0.09
90 INT232559 Map3k1 Positive_regulation of Esr1 1 0.19 0.26 0.09
91 INT261396 Nsdhl Positive_regulation of Transcription of Esr1 1 0.02 2.1 0.09
92 INT341776 ESR1 Positive_regulation of Gene_expression of SLC6A3 1 0.06 0.08 0.09
93 INT232557 Erbb2 Positive_regulation of Esr1 1 0.23 0.26 0.09
94 INT52836 ESR1 Positive_regulation of HSD17B7 1 0.43 0.41 0.09
95 INT173371 GPER Regulation of ITGAL 1 0.01 0.23 0.08
96 INT192863 Binding of Ddit3 and Esr1 1 0.09 0.67 0.08
97 INT192860 Binding of Calr and Esr1 1 0.06 0.67 0.08
98 INT192865 Binding of Esr1 and Pdia3 1 0.07 0.67 0.08
99 INT192862 Binding of Esr1 and Hspa5 1 0.08 0.68 0.08
100 INT309159 Binding of Cav1 and Positive_regulation of Localization of Esr1 1 0.04 0 0.08
101 INT173408 GPER Regulation of Itgb2 1 0.01 0.23 0.08
102 INT199973 ESR1 Negative_regulation of EEF1B2P2 1 0.01 0.46 0.08
103 INT173376 GPER Regulation of ITGAX 1 0.00 0.23 0.08
104 INT227836 Binding of ERCC6 and GPER 1 0.21 0.27 0.08
105 INT38188 PGR Positive_regulation of Gene_expression of ESR1 1 0.42 0.22 0.07
106 INT237811 Binding of Esr1 and Stim1 1 0.09 0 0.07
107 INT173372 GPER Regulation of Binding of FCGR3B 1 0.03 0.21 0.07
108 INT339108 Binding of ESR1 and JUP 1 0.38 0.62 0.07
109 INT224293 AR Positive_regulation of Protein_catabolism of ESR1 1 0.24 0.4 0.07
110 INT237809 Esr1 Positive_regulation of Localization of Car2 1 0.09 0.66 0.07
111 INT206855 Binding of ESR1 and PPARA 1 0.03 1.21 0.07
112 INT272388 Esr1 Regulation of Transcription of Trpv6 1 0.03 0.13 0.06
113 INT197594 Esr1 Regulation of Esr2 1 0.04 0 0.06
114 INT173400 Negative_regulation of Binding of GPER and Itgam 1 0.01 0.19 0.06
115 INT187845 Binding of ESR1 and Esr2 1 0.01 0.17 0.06
116 INT197592 Esr2 Regulation of Esr1 1 0.04 0 0.06
117 INT142744 Esr1 Regulation of Transcription of Trpv6 1 0.42 0 0.06
118 INT173407 Binding of GPER and Itgam 1 0.01 0.26 0.06
119 INT197586 Esr2 Regulation of Pgr 1 0.09 0 0.06
120 INT206846 ESR1 Regulation of Gene_expression of PLP1 1 0.06 1.02 0.05
121 INT242974 Mapk8 Negative_regulation of Positive_regulation of Esr1 1 0.01 1.39 0.05
122 INT236591 Binding of Esr1 and Positive_regulation of Tmed4 1 0.04 0.52 0.05
123 INT240726 Binding of Esr1 and Ca2 1 0.02 0.57 0.05
124 INT316248 ESR1 Regulation of Gene_expression of TRPM8 1 0.34 0.17 0.05
125 INT244461 CS Positive_regulation of ESR1 1 0.06 1.15 0.05
126 INT225493 Binding of Esr1 and Pprc1 2 0.01 0.17 0.04
127 INT335702 Esr1 Regulation of Calr 1 0.03 0 0.04
128 INT206848 PLP1 Regulation of Gene_expression of ESR1 1 0.07 0.9 0.04
129 INT206853 ESR1 Positive_regulation of Gene_expression of PCP4 1 0.08 1.39 0.04
130 INT206845 ANXA1 Regulation of Gene_expression of ESR1 1 0.07 0.9 0.04
131 INT201445 ESR1 Regulation of Slc6a3 1 0.02 0.05 0.04
132 INT206851 NR4A1 Regulation of Gene_expression of ESR1 1 0.08 0.9 0.04
133 INT236595 Binding of Esr1 and PELP1 1 0.27 0.17 0.04
134 INT206896 ESR1 Positive_regulation of Gene_expression of Nr1i3 1 0.00 0.36 0.04
135 INT173374 GPER Negative_regulation of Binding of FCGR3B 1 0.03 0.16 0.04
136 INT173403 GPER Negative_regulation of Binding of Itgam 1 0.01 0.15 0.04
137 INT206847 ESR1 Negative_regulation of Gene_expression of PTGER3 1 0.08 1.52 0.04
138 INT197917 Binding of ESR1 and Sh2b2 1 0.01 0 0.04
139 INT173399 Binding of GPER and Ns5atp9 1 0.00 0.18 0.04
140 INT335703 Esr1 Regulation of Localization of Calr 1 0.03 0 0.04
141 INT206849 ESR1 Regulation of Gene_expression of ALDH1A1 1 0.11 2.26 0.04
142 INT206852 ESR1 Regulation of Gene_expression of CRABP2 1 0.08 1.52 0.04
143 INT183614 Binding of ESR1 and TMED4 2 0.02 0.13 0.03
144 INT278579 Esr1 Positive_regulation of Negative_regulation of Tac2 1 0.47 0.25 0.03
145 INT289101 Binding of KCNA1 and LEF1 1 0.00 2.58 0.03
146 INT187388 Esr2 Positive_regulation of Gene_expression of Pgr 1 0.00 0.8 0.03
147 INT278289 Binding of DBP and ESR1 1 0.03 0.82 0.03
148 INT175560 Binding of GPER and GHRL 1 0.01 1.14 0.03
149 INT213902 ESR1 Positive_regulation of EGFR 1 0.48 0.31 0.03
150 INT331960 Positive_regulation of Binding of Esr1 and Tymp 1 0.00 0.15 0.03
151 INT331958 Binding of Esr1 and Tymp 1 0.00 0.15 0.03
152 INT245075 Binding of ESR1 and NR4A1 1 0.01 1.08 0.03
153 INT316773 Esr1 Positive_regulation of Ddit3 1 0.02 0.41 0.03
154 INT278294 Binding of ESR1 and SHBG 1 0.01 0.82 0.03
155 INT221682 Binding of Esr1 and FRTS 1 0.01 0.15 0.03
156 INT213905 ESR1 Positive_regulation of SRC 1 0.14 0.31 0.03
157 INT215872 Atf4 Regulation of Esr1 1 0.30 0.42 0.03
158 INT192914 Binding of ESR1 and GOPC 2 0.02 0.61 0
159 INT260342 Binding of Esr1 and Rcc1 1 0.05 0.99 0
160 INT198111 Binding of Esr1 and Esr2 1 0.05 0 0
161 INT335214 Binding of ESR1 and RARS 1 0.08 0.92 0
162 INT178638 Gh1 Regulation of Gene_expression of ESR1 1 0.01 0.47 0
163 INT206895 Binding of ESR1 and Aldh1a1 1 0.03 0 0
164 INT264663 Binding of ESR1 and PRL 1 0.22 0.18 0
165 INT98354 TXNRD1 Positive_regulation of Positive_regulation of ESR1 1 0.00 0.05 0
166 INT306500 Clu Regulation of Esr1 1 0.22 0.13 0
167 INT332958 Binding of Esr1 and Ppara 1 0.36 0.21 0
168 INT225559 Binding of Esr1 and Ncoa6 1 0.18 0 0
169 INT337402 LEF1 Positive_regulation of E2F1 1 0.11 0 0
170 INT342281 Binding of INS and Esr1 1 0.08 0.57 0
171 INT206854 ESR1 Regulation of IGF1 1 0.01 0.33 0
172 INT173771 Gh1 Regulation of Transcription of Esr1 1 0.00 0.13 0
173 INT189115 Binding of Esr1 and Tap1 1 0.07 0.05 0
174 INT120549 Binding of ESR1 and Mpo 1 0.26 0.05 0
175 INT199975 ESR1 Positive_regulation of PGR 1 0.05 0.11 0
176 INT197677 Binding of ESR1 and Arg1 1 0.04 0 0
177 INT264662 ESR1 Regulation of Gene_expression of PRL 1 0.43 0.21 0
178 INT197615 Esr1 Regulation of Gene_expression of Pgr 1 0.01 0.21 0
179 INT176289 Pcna Positive_regulation of Phosphorylation of Esr1 1 0.01 0.67 0
180 INT336994 CALR Negative_regulation of ESR1 1 0.04 0 0
181 INT206850 Binding of CRABP2 and ESR1 1 0.06 0 0
182 INT273774 Binding of GPER and RB1 1 0.01 0.45 0
183 INT245077 Binding of ESR1 and CXCL12 1 0.06 1.42 0
184 INT191062 Esr1 Regulation of Gene_expression of Bcl2 1 0.12 0.73 0
185 INT313596 ESR1 Positive_regulation of Gene_expression of PGR 1 0.05 1 0
186 INT219421 Binding of ESR1 and MALAT1 1 0.34 0.63 0
187 INT314740 Binding of ESR1 and Brca1 1 0.16 0.69 0
188 INT183648 Binding of Lef1 and Ctnnd2 1 0.07 1.05 0
189 INT98353 THRB Negative_regulation of Positive_regulation of ESR1 1 0.00 0.09 0
190 INT173375 Binding of FCGR3B and GPER 1 0.02 0 0
191 INT191096 Negative_regulation of Binding of Apc and Esr1 1 0.05 1.07 0
192 INT208018 Col4a4 Regulation of Gene_expression of Esr1 1 0.06 0.69 0
193 INT224291 Negative_regulation of ESR1 Positive_regulation of CCND1 1 0.16 0.07 0
194 INT244457 CS Positive_regulation of Gene_expression of ESR1 1 0.07 0.67 0
195 INT337415 Negative_regulation of MIR203 Positive_regulation of Positive_regulation of LEF1 1 0.03 0.25 0
196 INT192913 Binding of ESR1 and HAMP 1 0.02 0.72 0
197 INT314687 ESR1 Regulation of PGR 1 0.27 0.88 0
198 INT337405 MIR203 Regulation of LEF1 1 0.02 0.31 0
199 INT197911 Dlst Positive_regulation of Gene_expression of Esr1 1 0.03 0.34 0
200 INT254435 Binding of Esr1 and Best1 1 0.21 0.06 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for estrogen receptor activity. They are ordered first by their pain relevance and then by number of times they were reported in estrogen receptor activity. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT5374 Gene_expression of Esr1 412 0.77 263.89 67.34
2 INT822 Gene_expression of ESR1 529 0.78 302.16 63.64
3 INT3361 Positive_regulation of Esr1 273 0.69 208.53 44.81
4 INT9082 Positive_regulation of ESR1 238 0.69 148.51 36.69
5 INT37296 Binding of Esr1 117 0.43 62.51 27.33
6 INT20462 Binding of ESR1 210 0.44 102.7 26.34
7 INT823 Negative_regulation of ESR1 144 0.58 63.72 22.52
8 INT4067 Negative_regulation of Esr1 97 0.50 43.45 17.52
9 INT17237 Regulation of Esr1 74 0.43 49.09 17.25
10 INT92354 Localization of ESR1 77 0.75 33.04 15.51
11 INT73916 Gene_expression of Esr1 58 0.77 26.59 15.15
12 INT2038 Localization of Esr1 104 0.79 40.12 13.27
13 INT79545 Positive_regulation of Gene_expression of ESR1 82 0.64 39.42 12.18
14 INT15687 Regulation of ESR1 91 0.60 40.42 7.95
15 INT31333 Gene_expression of Esr2 19 0.69 8.78 6.83
16 INT110987 Transcription of ESR1 45 0.71 24.16 6.72
17 INT22901 Negative_regulation of Gene_expression of Esr1 30 0.42 20.92 6.29
18 INT20280 Positive_regulation of Esr1 32 0.69 18.37 5.69
19 INT43997 Positive_regulation of Gene_expression of Esr1 57 0.51 36.66 5.51
20 INT16621 Negative_regulation of Esr1 20 0.54 8.2 4.84
21 INT133630 Negative_regulation of Gene_expression of ESR1 42 0.52 23.89 4.57
22 INT117205 Transcription of Esr1 23 0.65 9.4 4.14
23 INT77385 Gene_expression of Esr2 18 0.75 4.69 3.92
24 INT218955 Protein_catabolism of ESR1 9 0.92 3.95 3.74
25 INT25200 Positive_regulation of GPER 13 0.05 1.75 3.67
26 INT20461 Binding of Esr1 34 0.48 9.58 3.66
27 INT178631 Phosphorylation of ESR1 21 0.75 9.16 3.36
28 INT73918 Transcription of Esr1 21 0.66 8.74 3.12
29 INT10553 Regulation of GPER 13 0.15 2.12 3.02
30 INT31541 Regulation of Esr1 15 0.54 4.12 2.82
31 INT174727 Positive_regulation of Positive_regulation of ESR1 14 0.44 6.3 2.7
32 INT108796 Binding of ESR2 5 0.46 6.84 2.36
33 INT102234 Gene_expression of ESR2 17 0.65 9.29 2.3
34 INT54615 Gene_expression of GPER 25 0.75 8.23 2.27
35 INT109800 Binding of Esr2 8 0.42 1.79 1.93
36 INT73913 Regulation of Gene_expression of Esr1 2 0.41 2.24 1.92
37 INT218959 Negative_regulation of Protein_catabolism of ESR1 3 0.37 0.97 1.9
38 INT33845 Binding of GPER 20 0.36 5.61 1.81
39 INT153918 Binding of Esr2 3 0.33 2.56 1.7
40 INT96971 Positive_regulation of Gene_expression of Esr1 6 0.46 2.27 1.67
41 INT30076 Negative_regulation of Esr2 1 0.01 0 1.63
42 INT222089 Positive_regulation of Localization of Esr1 19 0.49 8.73 1.58
43 INT278715 Gene_expression of LEF1 10 0.33 5.43 1.54
44 INT278727 Negative_regulation of Gene_expression of LEF1 3 0.11 1.59 1.47
45 INT152951 Negative_regulation of LEF1 5 0.41 3.22 1.31
46 INT158078 Gene_expression of Gper 7 0.67 1.13 1.26
47 INT8511 Localization of Esr1 6 0.80 3.27 1.26
48 INT128752 Negative_regulation of Localization of Esr1 11 0.43 4.8 1.23
49 INT824 Negative_regulation of Negative_regulation of ESR1 3 0.42 1.53 1.18
50 INT159162 Binding of Gper 2 0.48 1.69 1.12
51 INT81945 Negative_regulation of Binding of Esr1 3 0.32 0.55 1.06
52 INT158077 Regulation of Gper 2 0.35 0.91 1.04
53 INT66862 Regulation of Esr2 3 0.24 1.56 1.01
54 INT157531 Gene_expression of Gpr30 2 0.53 1.12 0.99
55 INT71906 Regulation of Gene_expression of ESR1 22 0.41 11.01 0.98
56 INT154468 Negative_regulation of Transcription of ESR1 3 0.29 1.14 0.96
57 INT173747 Regulation of Positive_regulation of Esr1 4 0.37 4.85 0.95
58 INT236576 Positive_regulation of Binding of Esr1 3 0.41 2.39 0.92
59 INT154465 Negative_regulation of Transcription of Esr1 1 0.05 0 0.92
60 INT128755 Protein_catabolism of Esr1 10 0.57 4.61 0.9
61 INT73914 Negative_regulation of Transcription of Esr1 3 0.39 0.75 0.84
62 INT174728 Positive_regulation of Transcription of ESR1 10 0.47 3.3 0.83
63 INT125092 Negative_regulation of Binding of ESR1 8 0.42 4.15 0.82
64 INT33818 Positive_regulation of Negative_regulation of Esr1 3 0.40 0.98 0.82
65 INT278710 Phosphorylation of LEF1 1 0.05 0.76 0.82
66 INT63694 Regulation of Positive_regulation of GPER 1 0.00 0.41 0.79
67 INT158075 Positive_regulation of Esr2 1 0.28 0.5 0.77
68 INT10554 Regulation of Regulation of GPER 3 0.01 0.45 0.76
69 INT84726 Gene_expression of NKX3-1 4 0.75 2.1 0.75
70 INT161778 Regulation of Gene_expression of Esr1 13 0.51 9.46 0.73
71 INT92082 Regulation of Binding of ESR1 5 0.45 2.41 0.73
72 INT66598 Negative_regulation of GPER 8 0.04 3.83 0.72
73 INT239494 Regulation of Localization of Esr1 4 0.19 1.15 0.72
74 INT73917 Regulation of Transcription of Esr1 4 0.25 1.5 0.7
75 INT150831 Localization of Gper 1 0.65 0.33 0.67
76 INT70121 Protein_catabolism of GPER 1 0.00 0.06 0.65
77 INT191177 Regulation of Localization of ESR1 7 0.42 2.04 0.64
78 INT9836 Negative_regulation of Negative_regulation of Esr1 3 0.29 0.95 0.63
79 INT173748 Phosphorylation of Esr1 11 0.77 5.7 0.55
80 INT328633 Transcription of GPER 2 0.06 2.57 0.54
81 INT173744 Positive_regulation of Positive_regulation of Esr1 10 0.43 7.05 0.52
82 INT181281 Localization of NKX3-1 1 0.12 0.3 0.5
83 INT190899 Negative_regulation of Phosphorylation of ESR1 3 0.33 1.01 0.49
84 INT30075 Localization of Esr2 2 0.01 0.78 0.49
85 INT240710 Positive_regulation of Regulation of Esr1 1 0.09 1.34 0.47
86 INT84724 Negative_regulation of Gene_expression of NKX3-1 1 0.41 0.43 0.44
87 INT174725 Positive_regulation of Localization of ESR1 8 0.47 2.45 0.41
88 INT109801 Transcription of Esr2 2 0.69 2.08 0.41
89 INT348631 Regulation of Esr2 1 0.40 0.87 0.4
90 INT268930 Regulation of Regulation of Esr1 2 0.41 0.48 0.38
91 INT186535 Negative_regulation of Gene_expression of Esr2 2 0.25 1.07 0.38
92 INT178630 Positive_regulation of Negative_regulation of ESR1 2 0.04 0.64 0.35
93 INT194086 Negative_regulation of Gene_expression of ESR2 1 0.03 1.22 0.35
94 INT236580 Regulation of Binding of Esr1 4 0.39 1.1 0.34
95 INT176586 Positive_regulation of Binding of ESR1 11 0.41 4.64 0.33
96 INT111230 Transcription of LEF1 3 0.30 1.72 0.33
97 INT183916 Negative_regulation of Binding of Esr1 1 0.06 0.91 0.32
98 INT192845 Negative_regulation of Positive_regulation of Esr1 2 0.35 1.15 0.31
99 INT66863 Regulation of Gene_expression of Esr2 1 0.03 0 0.31
100 INT73915 Negative_regulation of Negative_regulation of Esr1 1 0.40 0.06 0.31
101 INT323166 Binding of Gpr30 1 0.16 0.2 0.28
102 INT153772 Negative_regulation of Localization of ESR1 7 0.54 4.42 0.27
103 INT102801 Regulation of ESR2 1 0.51 0 0.27
104 INT102800 Regulation of Gene_expression of ESR2 1 0.22 0 0.27
105 INT167917 Regulation of Gene_expression of GPER 2 0.26 0.58 0.26
106 INT138751 Localization of ESR2 2 0.72 1.51 0.24
107 INT96972 Positive_regulation of Binding of Esr1 4 0.22 1.35 0.21
108 INT186021 Positive_regulation of Positive_regulation of Esr1 1 0.08 0 0.19
109 INT339342 Binding of NKX3-1 1 0.04 0.08 0.18
110 INT176571 Negative_regulation of Positive_regulation of ESR1 5 0.47 3.15 0.17
111 INT291955 Positive_regulation of Protein_catabolism of Esr1 1 0.06 0.14 0.17
112 INT269777 Regulation of Regulation of Esr1 2 0.02 1.17 0.16
113 INT176461 Protein_catabolism of Esr1 1 0.12 0.37 0.16
114 INT167918 Positive_regulation of Gene_expression of GPER 2 0.45 1.16 0.15
115 INT183400 Positive_regulation of Transcription of Esr1 4 0.30 1.06 0.14
116 INT291541 Negative_regulation of Gper 1 0.33 0.14 0.14
117 INT162109 Negative_regulation of Gene_expression of Esr1 4 0.16 2.41 0.12
118 INT232556 Positive_regulation of Phosphorylation of Esr1 1 0.20 0.41 0.12
119 INT173384 Regulation of Binding of GPER 2 0.17 0.58 0.1
120 INT261361 Negative_regulation of Esr2 1 0.15 0.67 0.09
121 INT201434 Negative_regulation of Gene_expression of Gper 1 0.11 0 0.08
122 INT224299 Positive_regulation of Protein_catabolism of ESR1 3 0.64 1.43 0.07
123 INT178868 Regulation of Positive_regulation of ESR1 1 0.42 0.52 0.07
124 INT253882 Positive_regulation of Localization of Esr1 1 0.30 1.21 0.06
125 INT220802 Binding of LEF1 7 0.36 3.86 0.04
126 INT289116 Positive_regulation of Localization of LEF1 2 0.22 1.19 0.04
127 INT289110 Localization of LEF1 2 0.32 1.19 0.04
128 INT176573 Positive_regulation of Esr2 2 0.01 1.43 0.04
129 INT272379 Positive_regulation of Transcription of Esr1 1 0.04 0.13 0.04
130 INT221677 Negative_regulation of Protein_catabolism of Esr1 1 0.08 0.15 0.03
131 INT174726 Regulation of Regulation of ESR1 1 0.41 0.73 0.03
132 INT289127 Positive_regulation of LEF1 2 0.22 0.76 0
133 INT174724 Regulation of Transcription of ESR1 2 0.18 0.49 0
134 INT178629 Positive_regulation of Phosphorylation of ESR1 2 0.36 0.93 0
135 INT173385 Negative_regulation of Binding of GPER 1 0.04 0.48 0
136 INT335681 Regulation of Negative_regulation of Esr1 1 0.03 0 0
137 INT337456 Positive_regulation of Binding of LEF1 1 0.22 0 0
138 INT307589 Positive_regulation of Gene_expression of ESR2 1 0.42 0.5 0
139 INT173746 Regulation of Transcription of Esr1 1 0.04 0 0
140 INT234916 Gene_expression of Lef1 1 0.04 0.25 0
141 INT289129 Positive_regulation of Gene_expression of LEF1 1 0.13 0.76 0
142 INT138752 Transcription of ESR2 1 0.60 0 0
143 INT227863 Localization of GPER 1 0.30 0.07 0
144 INT173388 Negative_regulation of Negative_regulation of GPER 1 0.04 0.24 0
145 INT337461 Positive_regulation of Transcription of LEF1 1 0.22 0.26 0
146 INT223607 Regulation of Phosphorylation of ESR1 1 0.35 0.65 0
147 INT289108 Negative_regulation of Transcription of LEF1 1 0.11 0.32 0
148 INT102799 Negative_regulation of ESR2 1 0.35 0 0
149 INT233573 Negative_regulation of NKX3-1 1 0.42 1.49 0
150 INT220775 Binding of Lef1 1 0.20 0.06 0
151 INT289124 Negative_regulation of Positive_regulation of LEF1 1 0.11 0.34 0
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