GO:0030295

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Name protein kinase activator activity
Categary Function
Go Slim No
Go Link GO:0030295
Unique Molecular Interactions 253
Total Molecular Interactions 374
Total Single Events 2265
Pain Genes Associated 14

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for protein kinase activator activity. They are ordered first by their pain relevance and then by number of times they were reported for protein kinase activator activity. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT184262 Binding of AGER and HMGB1 1 0.34 4.49 2.17
2 INT215100 Binding of Hmgb1 and Tlr4 5 0.29 3.21 1.68
3 INT215096 Binding of Hmgb1 and Tlr2 9 0.38 11.61 1.61
4 INT113337 EPO Positive_regulation of JAK2 1 0.76 2.8 1.55
5 INT114364 Hmgb1 Positive_regulation of Gene_expression of TNF 2 0.05 1.85 1.06
6 INT133650 Epo Negative_regulation of TNF 1 0.35 2.7 1.04
7 INT133652 Epo Negative_regulation of Gene_expression of TNF 1 0.35 2.64 0.96
8 INT219154 Binding of HMGB1 and TLR4 2 0.17 4.45 0.93
9 INT266408 Binding of HMGB1 and Ager 1 0.01 2.57 0.76
10 INT253759 Hmgb1 Positive_regulation of Apex1 1 0.09 4.53 0.69
11 INT215093 Tlr4 Positive_regulation of Localization of Hmgb1 1 0.32 2.9 0.68
12 INT111936 Binding of PIK3CA and PTK2 1 0.19 0.67 0.65
13 INT160119 EPO Regulation of Gene_expression of NFKB1 1 0.02 0.2 0.64
14 INT248172 Epo Regulation of Cysltr1 1 0.01 0.74 0.63
15 INT113338 Binding of EPO and KNCN 1 0.02 1.39 0.62
16 INT248170 Epo Regulation of Ltp 1 0.11 0.74 0.62
17 INT253760 Hmgb1 Positive_regulation of Gene_expression of Apex1 1 0.10 3.53 0.58
18 INT190181 Positive_regulation of PIK3CA Positive_regulation of MMP12 1 0.01 0.54 0.56
19 INT323611 Il1 Regulation of Hmgb1 1 0.17 2.36 0.55
20 INT215101 Hmgb1 Positive_regulation of Localization of Il6 4 0.16 1.18 0.54
21 INT253767 Binding of Hmgb1 and Tlr9 2 0.12 1.78 0.52
22 INT184111 Epo Positive_regulation of Il7 1 0.06 0.26 0.52
23 INT184130 Epo Positive_regulation of Stat5a 1 0.31 0.26 0.52
24 INT184088 Epo Positive_regulation of Il2 1 0.07 0.26 0.52
25 INT253770 Hmgb1 Positive_regulation of Localization of Apex1 1 0.08 0.71 0.49
26 INT341428 EPO Positive_regulation of NGF 1 0.52 0.37 0.48
27 INT341427 EPO Positive_regulation of BDNF 1 0.52 0.36 0.48
28 INT341426 EPO Regulation of NGF 1 0.51 0.5 0.47
29 INT341425 EPO Regulation of BDNF 1 0.51 0.5 0.47
30 INT262819 Gene_expression of Serpinf1 Negative_regulation of Binding of 1190002H23Rik 1 0.05 2.66 0.43
31 INT257738 PIK3CA Regulation of Localization of ACTN4 1 0.16 1.03 0.39
32 INT133651 Epo Regulation of TNF 1 0.50 1.25 0.38
33 INT266419 HMGB1 Positive_regulation of Ager 1 0.01 1.37 0.37
34 INT324823 Tlr4 Positive_regulation of Gene_expression of Hmgb1 1 0.21 0.51 0.37
35 INT324803 Hmgb1 Positive_regulation of Gene_expression of Bad 1 0.02 0.44 0.37
36 INT324818 Hmgb1 Positive_regulation of Gene_expression of Tlr4 1 0.21 0.51 0.37
37 INT324819 Hmgb1 Positive_regulation of Gene_expression of Maob 1 0.09 0.44 0.37
38 INT324827 Hmgb1 Positive_regulation of Bad 1 0.02 0.43 0.36
39 INT277985 Epo Positive_regulation of Epc1 1 0.03 1.36 0.36
40 INT305193 Binding of Epo and Cebpz 1 0.05 0.48 0.35
41 INT257746 SHC1 Positive_regulation of Positive_regulation of PIK3CA 1 0.26 1.04 0.34
42 INT133653 Epo Regulation of Transcription of TNF 1 0.22 1.09 0.33
43 INT253762 Binding of Apex1 and Hmgb1 1 0.09 1.29 0.32
44 INT257743 Binding of PIK3CA and SHC1 1 0.21 1.03 0.31
45 INT101219 TNF Negative_regulation of Gene_expression of EPO 1 0.47 2.8 0.3
46 INT101220 TNF Negative_regulation of EPO 1 0.48 2.8 0.3
47 INT305204 Pbrgcsf1 Positive_regulation of Gene_expression of Epo 1 0.27 0.6 0.27
48 INT323612 Negative_regulation of Tlr4 Positive_regulation of Hmgb1 1 0.23 0.2 0.25
49 INT323610 Tlr4 Positive_regulation of Hmgb1 1 0.25 0.2 0.25
50 INT253765 Apex1 Positive_regulation of Hmgb1 1 0.09 1.27 0.24
51 INT343914 Hmgb1 Positive_regulation of Gene_expression of IL12A 1 0.01 0.41 0.24
52 INT253771 Gopc Positive_regulation of Hmgb1 1 0.03 1.27 0.24
53 INT343906 Hmgb1 Positive_regulation of Gene_expression of Cd40 1 0.05 0.41 0.24
54 INT266421 Binding of HMGB1 and Il1 1 0.02 0.37 0.24
55 INT336893 Epo Regulation of Epc2 1 0.00 0.69 0.23
56 INT253773 TNF Positive_regulation of Hmgb1 1 0.09 1.21 0.23
57 INT266418 Binding of HMGB1 and Tlr4 1 0.09 0.37 0.23
58 INT344833 Binding of Ager and Hmgb1 1 0.08 0.72 0.22
59 INT262817 Serpinf1 Regulation of Positive_regulation of 1190002H23Rik 1 0.06 1.3 0.22
60 INT187486 Binding of Prkag1 and Stk11 1 0.01 0.95 0.22
61 INT248171 Epo Regulation of Sult1a1 1 0.08 0.11 0.21
62 INT317394 Binding of Stk11 and Amp1 1 0.04 0.89 0.21
63 INT305203 Epo Positive_regulation of Gene_expression of Neurog1 1 0.06 0.4 0.21
64 INT266423 Binding of HMGB1 and Mapk3 1 0.04 0.9 0.2
65 INT266410 Binding of HMGB1 and Mapk14 1 0.03 0.91 0.2
66 INT266416 Binding of HMGB1 and Mapk1 1 0.06 0.9 0.2
67 INT266414 Binding of HMGB1 and Mapk8 1 0.03 0.91 0.2
68 INT266404 Binding of HMGB1 and Thbd 1 0.06 0.3 0.2
69 INT258289 Hmgb1 Positive_regulation of Tlr2 4 0.48 3.61 0.19
70 INT12694 SMS Regulation of Localization of EPO 1 0.06 0 0.19
71 INT324815 Binding of Hmgb1 and Caprin1 1 0.01 0.65 0.19
72 INT324797 Binding of Cd24a and Hmgb1 1 0.19 0.66 0.19
73 INT323613 Il1 Regulation of Localization of Hmgb1 1 0.10 0.75 0.19
74 INT339336 Binding of NKX3-1 and TAC4 1 0.03 0.08 0.18
75 INT262822 Serpinf1 Negative_regulation of Negative_regulation of 1190002H23Rik 1 0.07 1.27 0.18
76 INT12692 C1QL1 Positive_regulation of Localization of EPO 1 0.15 0 0.17
77 INT12693 SST Negative_regulation of Localization of EPO 1 0.08 0 0.17
78 INT215094 Il6 Positive_regulation of Hmgb1 1 0.18 1.84 0.17
79 INT344832 Hmgb1 Positive_regulation of Gene_expression of Nos2 1 0.12 0.82 0.17
80 INT266422 HMGB1 Positive_regulation of Binding of Ager 1 0.01 0.92 0.16
81 INT343475 Epo Regulation of Akt1 1 0.18 0.41 0.16
82 INT343478 Epo Regulation of Gene_expression of Akt1 1 0.40 0.41 0.16
83 INT343484 Epo Regulation of Gene_expression of VEGFA 1 0.24 0.41 0.16
84 INT336891 Epo Negative_regulation of Transcription of Bax 1 0.10 0.68 0.16
85 INT266413 Positive_regulation of Binding of HMGB1 and Col4a1 1 0.02 1.05 0.14
86 INT266411 Binding of HMGB1 and Col4a1 1 0.01 1.05 0.14
87 INT147726 Phosphorylation of PTK2 Regulation of Positive_regulation of PIK3CA 1 0.09 0.32 0.14
88 INT343920 Binding of TLR4 and Hmgb1 1 0.39 0.97 0.13
89 INT324866 Hmgb1 Positive_regulation of Tlr4 1 0.16 1.29 0.13
90 INT343917 Binding of IRF6 and Hmgb1 1 0.05 0.98 0.13
91 INT198671 HIF1A Regulation of Positive_regulation of Epo 1 0.00 1.37 0.13
92 INT352488 Binding of EPO and TNFRSF1A 1 0.14 0.18 0.12
93 INT253761 Hmgb1 Positive_regulation of Gene_expression of Gopc 1 0.03 0.73 0.12
94 INT351974 Agt Positive_regulation of Gene_expression of Stk11 1 0.51 11.1 0.12
95 INT305194 Bcl2 Positive_regulation of Epo 1 0.06 0.29 0.12
96 INT343472 Epo Positive_regulation of Gene_expression of Mmp2 1 0.15 0.62 0.12
97 INT277984 Negative_regulation of Epo Positive_regulation of Localization of Ptprc 1 0.02 0.77 0.12
98 INT277986 Negative_regulation of Epo Positive_regulation of Localization of Cd34 1 0.08 0.77 0.12
99 INT327808 EPO Regulation of VEGFA 1 0.07 1.36 0.12
100 INT253772 Binding of THBD and Hmgb1 1 0.05 0.95 0.12
101 INT253775 Negative_regulation of Binding of THBD and Hmgb1 1 0.06 0.69 0.12
102 INT288616 EPO Positive_regulation of Nos3 1 0.08 0.69 0.11
103 INT189559 STK11 Positive_regulation of SNRK 1 0.03 0.36 0.11
104 INT148957 Binding of Epo and Epor 1 0.01 0.56 0.1
105 INT317392 Negative_regulation of Binding of Stk11 and Amp1 1 0.05 0.34 0.1
106 INT200811 Epo Positive_regulation of Akt1 2 0.30 1.77 0.09
107 INT343486 Epo Positive_regulation of Localization of VEGFA 1 0.25 0.41 0.09
108 INT343485 Epo Positive_regulation of Gene_expression of VEGFA 1 0.25 0.51 0.09
109 INT215095 Negative_regulation of Il6 Positive_regulation of Hmgb1 1 0.13 1.03 0.09
110 INT42586 EPO Regulation of POMC 1 0.02 0.19 0.09
111 INT315204 Binding of Epo and Nefh 1 0.26 1.01 0.09
112 INT250730 Hmgb1 Positive_regulation of Localization of TNF 1 0.08 0.92 0.09
113 INT349031 Epo Positive_regulation of Akt1 1 0.36 0.23 0.09
114 INT42587 EPO Regulation of GHRH 1 0.01 0.19 0.09
115 INT246846 Binding of PIK3CA and Irs1 1 0.39 0.14 0.08
116 INT277835 EPO Positive_regulation of Localization of VEGFA 1 0.03 1.36 0.08
117 INT246845 Binding of PIK3CA and Ppp1r13b 1 0.13 0.15 0.08
118 INT317398 Amp1 Positive_regulation of Phosphorylation of Stk11 1 0.05 0.22 0.07
119 INT317391 Amp1 Positive_regulation of Stk11 1 0.05 0.22 0.07
120 INT305205 Binding of Epo and Pbrgcsf1 1 0.14 0.23 0.07
121 INT311432 Binding of TSHR and TAOK1 1 0.12 1.05 0.07
122 INT253139 Il6 Positive_regulation of Phosphorylation of Stk11 1 0.26 0.34 0.07
123 INT343481 Epo Positive_regulation of Igf1 1 0.15 0.31 0.06
124 INT343477 Epo Positive_regulation of Pdgfb 1 0.11 0.31 0.06
125 INT343479 Epo Positive_regulation of Fgf2 1 0.33 0.3 0.06
126 INT343480 Epo Positive_regulation of Mmp2 1 0.15 0.31 0.06
127 INT343471 Epo Positive_regulation of Gene_expression of Pdgfb 1 0.11 0.31 0.06
128 INT317389 Binding of Prkag1 and Stk11 1 0.16 0.2 0.06
129 INT317397 Negative_regulation of Binding of Prkag1 and Stk11 1 0.19 0.2 0.06
130 INT258290 Hmgb1 Regulation of Positive_regulation of Tlr2 1 0.46 1.04 0.05
131 INT226043 Epo Positive_regulation of Ecm1 1 0.04 1.35 0.05
132 INT254161 Epo Positive_regulation of Nos2 1 0.37 0.54 0.05
133 INT254162 Epo Positive_regulation of NOS1 1 0.01 0.53 0.05
134 INT315206 Binding of Epo and Positive_regulation of Binding of Cnp 1 0.44 0.39 0.04
135 INT102247 Binding of EPO and HIF1A 1 0.41 0.65 0.04
136 INT200809 Binding of Akt1 and Epo 1 0.23 0.98 0.03
137 INT179951 Binding of PIK3CA and Ins1 1 0.39 0.32 0.03
138 INT326046 Binding of Epo and Csf2 1 0.38 0.22 0.03
139 INT343487 Epo Positive_regulation of Gene_expression of EPOR 1 0.76 0.32 0.03
140 INT324859 Hmgb1 Positive_regulation of ecs 1 0.03 0.74 0.03
141 INT317388 Stk11 Regulation of Positive_regulation of Prkag1 1 0.23 0.11 0.03
142 INT324798 Hmgb1 Positive_regulation of Positive_regulation of Mthfd1 1 0.04 0.16 0.03
143 INT179950 Binding of PIK3CA and Irs1 1 0.32 0.31 0.03
144 INT346331 Binding of Epo and Egf 1 0.19 0.1 0.03
145 INT295476 PIK3CA Regulation of Gene_expression of TNF 1 0.00 0.05 0.03
146 INT326045 Epo Positive_regulation of Mki67 1 0.16 0.18 0.03
147 INT200814 Epo Positive_regulation of Lyn 1 0.36 1.42 0.03
148 INT200815 Binding of Epo and Jak2 1 0.36 0.98 0.03
149 INT343476 Epo Positive_regulation of Kdr 1 0.11 0.31 0.03
150 INT200820 Epo Positive_regulation of Src 1 0.25 1.41 0.03
151 INT317404 Acc Positive_regulation of Stk11 1 0.41 0.06 0.03
152 INT343474 Epo Positive_regulation of Gene_expression of Kdr 1 0.11 0.32 0.03
153 INT336894 Binding of Epo and Epc2 1 0.00 0.55 0.03
154 INT343488 Epo Positive_regulation of EPOR 1 0.24 0.31 0.03
155 INT326052 Epo Positive_regulation of PCNA 1 0.04 0.17 0.03
156 INT254089 EPO Regulation of Gene_expression of Bcl2 1 0.03 0.63 0
157 INT351972 Binding of Agt and Stk11 1 0.27 0.74 0
158 INT324561 Hmgb1 Positive_regulation of Gene_expression of Arc 1 0.18 0.65 0
159 INT326047 Csf2 Regulation of Epo 1 0.29 0.22 0
160 INT314393 Ptpn6 Regulation of 1190002H23Rik 1 0.01 0 0
161 INT301246 Binding of HMGB1 and Hbp1 1 0.03 0.74 0
162 INT241852 Binding of EPO and EPCAM 1 0.06 0.84 0
163 INT8771 EPO Positive_regulation of HBG1 1 0.52 0.73 0
164 INT326049 Csf2 Negative_regulation of Epo 1 0.46 0.25 0
165 INT343473 Epo Positive_regulation of Gene_expression of Akt1 1 0.45 0.05 0
166 INT304012 Binding of AKT1 and PIK3CA 1 0.28 1.14 0
167 INT200819 Epo Positive_regulation of Gene_expression of Jak2 1 0.49 0.91 0
168 INT351975 Agt Positive_regulation of Stk11 1 0.34 0.39 0
169 INT239406 Binding of MTTP and TAOK1 1 0.02 0.51 0
170 INT314402 Positive_regulation of Ptpn6 Regulation of 1190002H23Rik 1 0.02 0 0
171 INT241307 Positive_regulation of HIF1A Positive_regulation of Positive_regulation of EPO 1 0.12 0.64 0
172 INT253769 Binding of Hmgb1 and Il1 1 0.01 0.27 0
173 INT247575 Binding of Epo and Hif1a 1 0.09 1.24 0
174 INT220286 Epo Regulation of hb 1 0.23 0.21 0
175 INT304025 Binding of PIK3CA and TP53 1 0.30 0.67 0
176 INT351984 Gene_expression of Stk11 Positive_regulation of Gene_expression of Dcc 1 0.01 1.8 0
177 INT198025 PIK3CA Positive_regulation of Gene_expression of MCL1 1 0.28 1.24 0
178 INT304015 Binding of PIK3CA and PIK3CG 1 0.09 0.67 0
179 INT351982 Smarca4 Positive_regulation of Stk11 1 0.05 0.58 0
180 INT273480 Binding of EPO and RNASEL 1 0.08 0.77 0
181 INT286420 Binding of Fgf13 and Mapk8ip3 1 0.36 0 0
182 INT292566 Binding of TNFRSF1A and MADD 1 0.05 0.09 0
183 INT351985 Stk11 Positive_regulation of Gene_expression of Dcc 1 0.01 1.79 0
184 INT351976 Binding of Tp53 and Stk11 1 0.13 2.3 0
185 INT239408 Binding of PADI1 and TAOK1 1 0.01 0.51 0
186 INT254090 EPO Negative_regulation of Gene_expression of Bax 1 0.10 0.63 0
187 INT151589 Stk11 Positive_regulation of Prkag1 1 0.41 0.17 0
188 INT314860 Gene_expression of Atoh7 Positive_regulation of 1190002H23Rik 1 0.02 0.27 0
189 INT324558 Hmgb1 Positive_regulation of Gene_expression of Kiss1 1 0.24 0.65 0
190 INT198001 Negative_regulation of PIK3CA Negative_regulation of Gene_expression of MCL1 1 0.26 0.89 0
191 INT266098 Bdnf Negative_regulation of Negative_regulation of 1190002H23Rik 1 0.05 0.41 0
192 INT198020 PIK3CA Regulation of Gene_expression of MCL1 1 0.16 2.25 0
193 INT259094 STK11 Positive_regulation of Gene_expression of TCEAL1 1 0.18 5.5 0
194 INT305201 Pbrgcsf1 Positive_regulation of Epo 1 0.18 0.07 0
195 INT254091 EPO Positive_regulation of Gene_expression of Bcl2l1 1 0.11 0.66 0
196 INT278760 EPO Positive_regulation of RAP1A 1 0.13 0.16 0
197 INT331117 EPO Positive_regulation of FXN 1 0.29 1.09 0
198 INT225904 Binding of GAB1 and PIK3CA 1 0.07 0.06 0
199 INT183750 Binding of EPO and TF 1 0.42 1.21 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for protein kinase activator activity. They are ordered first by their pain relevance and then by number of times they were reported in protein kinase activator activity. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT114362 Localization of Hmgb1 127 0.78 120.28 23.26
2 INT2843 Gene_expression of Epo 100 0.78 62.01 14.66
3 INT18012 Gene_expression of EPO 169 0.78 108.36 13.75
4 INT39553 Gene_expression of Hmgb1 50 0.75 51.18 12.21
5 INT114363 Positive_regulation of Hmgb1 50 0.67 48.92 8.15
6 INT212758 Binding of Hmgb1 40 0.44 35.6 7.41
7 INT3098 Positive_regulation of Epo 46 0.70 28.27 7
8 INT15872 Positive_regulation of EPO 74 0.70 45.35 6.67
9 INT3738 Regulation of Epo 25 0.61 13.73 6.18
10 INT190520 Negative_regulation of Hmgb1 24 0.53 20.08 5.6
11 INT184269 Gene_expression of HMGB1 51 0.77 42.96 4.55
12 INT54895 Binding of Epo 24 0.48 11.38 4.48
13 INT215071 Positive_regulation of Localization of Hmgb1 34 0.63 22.03 4.15
14 INT215085 Positive_regulation of Gene_expression of Hmgb1 17 0.63 16.81 4.13
15 INT215074 Negative_regulation of Localization of Hmgb1 28 0.57 15.09 4
16 INT184288 Localization of HMGB1 20 0.61 14.5 3.84
17 INT53065 Negative_regulation of Gene_expression of EPO 15 0.49 16.39 3.12
18 INT45503 Binding of EPO 42 0.48 24.85 2.88
19 INT89397 Positive_regulation of PIK3CA 33 0.67 16.98 2.78
20 INT8112 Regulation of EPO 38 0.58 22.04 2.76
21 INT164116 Negative_regulation of 1190002H23Rik 33 0.51 18.73 2.71
22 INT8111 Localization of EPO 32 0.81 19.53 2.54
23 INT184272 Binding of HMGB1 14 0.37 8.78 2.49
24 INT45597 Negative_regulation of Epo 22 0.59 12.47 2.35
25 INT11905 Protein_catabolism of EPO 6 1.00 2.36 2
26 INT178030 Localization of Epo 11 0.78 6.03 1.86
27 INT15742 Negative_regulation of EPO 37 0.59 17.44 1.84
28 INT253755 Regulation of Hmgb1 7 0.55 6.23 1.8
29 INT198663 Positive_regulation of HMGB1 14 0.52 11.41 1.58
30 INT55479 Localization of Epo 13 0.81 6.1 1.53
31 INT184271 Positive_regulation of Gene_expression of HMGB1 7 0.41 6.17 1.53
32 INT178029 Gene_expression of Epo 25 0.76 14.98 1.46
33 INT27762 Positive_regulation of Gene_expression of EPO 18 0.70 17.67 1.45
34 INT60685 Positive_regulation of Gene_expression of Epo 21 0.53 15.86 1.25
35 INT178023 Regulation of Epo 11 0.45 3.87 1.22
36 INT164115 Gene_expression of 1190002H23Rik 11 0.58 5.18 1.17
37 INT219168 Positive_regulation of Localization of HMGB1 5 0.36 4 1.16
38 INT120421 Gene_expression of Fgf13 6 0.68 0.45 1.12
39 INT215077 Negative_regulation of Positive_regulation of Hmgb1 3 0.42 5.09 1.05
40 INT215078 Negative_regulation of Gene_expression of Hmgb1 4 0.41 4.3 0.96
41 INT178026 Positive_regulation of Epo 12 0.70 8.14 0.95
42 INT53066 Positive_regulation of Positive_regulation of EPO 4 0.49 2.38 0.95
43 INT94565 Regulation of Regulation of Epo 1 0.07 0.14 0.95
44 INT60122 Negative_regulation of MADD 3 0.11 2.23 0.93
45 INT190522 Regulation of Gene_expression of Hmgb1 1 0.39 1.47 0.77
46 INT84726 Gene_expression of NKX3-1 4 0.75 2.1 0.75
47 INT54896 Positive_regulation of Binding of Epo 1 0.49 0.24 0.75
48 INT164112 Localization of 1190002H23Rik 4 0.65 1.34 0.67
49 INT164113 Negative_regulation of Negative_regulation of 1190002H23Rik 10 0.51 3.98 0.62
50 INT52345 Regulation of Gene_expression of Epo 4 0.45 2.07 0.61
51 INT106020 Transcription of EPO 8 0.71 9.34 0.6
52 INT269801 Gene_expression of MADD 1 0.14 4.17 0.6
53 INT248166 Protein_catabolism of Epo 1 0.89 0.71 0.59
54 INT184277 Regulation of Localization of HMGB1 1 0.37 1.15 0.58
55 INT190479 Positive_regulation of 1190002H23Rik 6 0.07 5.64 0.53
56 INT253108 Phosphorylation of Stk11 4 0.65 2.13 0.52
57 INT118607 Positive_regulation of Positive_regulation of Epo 4 0.50 3.67 0.5
58 INT181281 Localization of NKX3-1 1 0.12 0.3 0.5
59 INT343799 Negative_regulation of Transcription of HMGB1 1 0.32 0.37 0.5
60 INT215070 Regulation of Localization of Hmgb1 4 0.26 2.23 0.49
61 INT220339 Transcription of HMGB1 2 0.53 2.03 0.49
62 INT67068 Positive_regulation of Protein_catabolism of EPO 1 0.47 0 0.49
63 INT120420 Negative_regulation of Gene_expression of Fgf13 1 0.38 0.2 0.48
64 INT140144 Binding of 1190002H23Rik 4 0.05 2.69 0.47
65 INT219178 Negative_regulation of Localization of HMGB1 1 0.22 1.26 0.45
66 INT84724 Negative_regulation of Gene_expression of NKX3-1 1 0.41 0.43 0.44
67 INT352592 Positive_regulation of Negative_regulation of Hmgb1 1 0.44 1.31 0.42
68 INT47415 Transcription of Epo 3 0.67 1.42 0.41
69 INT241717 Regulation of Localization of Epo 1 0.10 0.55 0.37
70 INT89403 Negative_regulation of PIK3CA 19 0.57 11.74 0.35
71 INT12697 Negative_regulation of Localization of EPO 2 0.58 1.35 0.35
72 INT351970 Gene_expression of Stk11 1 0.75 33.89 0.35
73 INT226037 Binding of Epo 5 0.36 2.99 0.32
74 INT257764 Positive_regulation of Positive_regulation of PIK3CA 5 0.44 2.72 0.31
75 INT106482 Negative_regulation of Gene_expression of Epo 3 0.07 10.96 0.31
76 INT55478 Regulation of Localization of Epo 3 0.62 0.48 0.31
77 INT311448 Gene_expression of TAOK1 1 0.21 2.47 0.31
78 INT258283 Positive_regulation of Positive_regulation of Hmgb1 3 0.44 3.1 0.3
79 INT331591 Transcription of Hmgb1 1 0.28 0.92 0.3
80 INT86771 Positive_regulation of TAOK1 2 0.38 4.55 0.29
81 INT164117 Positive_regulation of Negative_regulation of 1190002H23Rik 3 0.40 2.16 0.27
82 INT120425 Binding of Fgf13 2 0.33 0.07 0.24
83 INT120424 Localization of Fgf13 1 0.70 0.09 0.23
84 INT89399 Negative_regulation of Positive_regulation of PIK3CA 3 0.57 1 0.22
85 INT120423 Positive_regulation of Gene_expression of Fgf13 2 0.44 0.09 0.22
86 INT220336 Negative_regulation of HMGB1 3 0.43 0.97 0.21
87 INT288613 Regulation of Transcription of EPO 1 0.41 1.01 0.21
88 INT266367 Positive_regulation of Binding of HMGB1 1 0.26 0.31 0.21
89 INT147732 Binding of PIK3CA 3 0.36 1.13 0.2
90 INT56199 Negative_regulation of Positive_regulation of EPO 3 0.37 2.44 0.2
91 INT273491 Negative_regulation of Transcription of EPO 1 0.58 4.29 0.2
92 INT266364 Protein_catabolism of HMGB1 1 0.34 0.29 0.19
93 INT351969 Positive_regulation of Gene_expression of Stk11 1 0.67 21.03 0.19
94 INT248169 Positive_regulation of Transcription of Epo 1 0.50 0 0.19
95 INT248165 Transcription of Epo 1 0.69 0 0.19
96 INT349030 Regulation of Binding of Epo 1 0.39 0.12 0.19
97 INT200796 Negative_regulation of Epo 7 0.43 3.22 0.18
98 INT311439 Positive_regulation of Gene_expression of TAOK1 1 0.15 1.48 0.18
99 INT339342 Binding of NKX3-1 1 0.04 0.08 0.18
100 INT266353 Negative_regulation of Binding of HMGB1 1 0.22 0.22 0.17
101 INT246833 Positive_regulation of Binding of PIK3CA 1 0.49 0.29 0.16
102 INT196603 Gene_expression of STK11 5 0.55 6.75 0.15
103 INT258272 Negative_regulation of Binding of Hmgb1 1 0.53 1.82 0.15
104 INT147731 Phosphorylation of PIK3CA 3 0.44 1.93 0.14
105 INT189633 Regulation of STK11 3 0.41 3.57 0.14
106 INT136021 Positive_regulation of Localization of EPO 2 0.23 1.63 0.14
107 INT344828 Protein_catabolism of Hmgb1 1 0.48 0.67 0.14
108 INT344810 Positive_regulation of Protein_catabolism of Hmgb1 1 0.27 0.67 0.14
109 INT59286 Regulation of Gene_expression of EPO 7 0.62 6.13 0.13
110 INT228608 Positive_regulation of Gene_expression of Epo 5 0.68 2.85 0.13
111 INT106227 Binding of STK11 3 0.42 3.13 0.13
112 INT189583 Transcription of STK11 2 0.49 4.43 0.13
113 INT330233 Positive_regulation of Stk11 2 0.67 8.15 0.13
114 INT164111 Positive_regulation of Gene_expression of 1190002H23Rik 4 0.43 0.61 0.12
115 INT151587 Positive_regulation of Stk11 2 0.38 0.44 0.12
116 INT127987 Regulation of Binding of EPO 3 0.45 0.6 0.1
117 INT318343 Regulation of Binding of Hmgb1 1 0.11 0.41 0.1
118 INT206737 Negative_regulation of Gene_expression of HMGB1 3 0.32 3.48 0.09
119 INT46823 Regulation of Regulation of EPO 1 0.23 0.44 0.09
120 INT343457 Regulation of Binding of Epo 1 0.44 0 0.09
121 INT147733 Regulation of Binding of PIK3CA 1 0.10 0.23 0.08
122 INT253107 Regulation of Stk11 2 0.33 0.3 0.07
123 INT253102 Negative_regulation of Stk11 1 0.31 0.22 0.07
124 INT130942 Positive_regulation of Regulation of EPO 1 0.47 0.54 0.07
125 INT311444 Binding of TAOK1 1 0.11 0.65 0.05
126 INT330228 Phosphorylation of Stk11 1 0.18 0.27 0.05
127 INT330227 Positive_regulation of Positive_regulation of Stk11 1 0.11 0.06 0.05
128 INT351967 Negative_regulation of Gene_expression of Stk11 1 0.57 0.89 0.04
129 INT226039 Positive_regulation of Positive_regulation of Epo 1 0.45 1.38 0.04
130 INT208224 Protein_catabolism of TAOK1 1 0.05 0.94 0.04
131 INT351966 Binding of Stk11 1 0.36 2.15 0.04
132 INT176154 Gene_expression of PIK3CA 6 0.55 10.43 0.03
133 INT176150 Localization of PIK3CA 2 0.73 0.22 0.03
134 INT299469 Regulation of HMGB1 2 0.18 2.27 0.03
135 INT253104 Gene_expression of Stk11 2 0.53 0.07 0.03
136 INT220284 Phosphorylation of Epo 2 0.63 1.2 0.03
137 INT317354 Regulation of Phosphorylation of Stk11 1 0.36 0.12 0.03
138 INT176160 Positive_regulation of Localization of PIK3CA 1 0.13 0.22 0.03
139 INT266358 Regulation of Binding of HMGB1 1 0.14 0 0.03
140 INT241860 Positive_regulation of Transcription of EPO 3 0.55 4 0
141 INT286389 Positive_regulation of Fgf13 2 0.42 0.33 0
142 INT198037 Regulation of PIK3CA 2 0.28 2.63 0
143 INT116425 Phosphorylation of EPO 2 0.78 0.63 0
144 INT259109 Negative_regulation of STK11 2 0.54 2.11 0
145 INT291365 Positive_regulation of Gene_expression of PIK3CA 2 0.41 5.76 0
146 INT299470 Regulation of Gene_expression of HMGB1 1 0.18 1.58 0
147 INT241316 Positive_regulation of Binding of EPO 1 0.44 0 0
148 INT315886 Regulation of Positive_regulation of PIK3CA 1 0.10 0.53 0
149 INT351968 Negative_regulation of Stk11 1 0.42 4.84 0
150 INT325779 Positive_regulation of Phosphorylation of EPO 1 0.48 0.2 0
151 INT351971 Regulation of Stk11 1 0.26 0.43 0
152 INT317352 Positive_regulation of Phosphorylation of Stk11 1 0.32 0 0
153 INT289494 Regulation of 1190002H23Rik 1 0.04 1.64 0
154 INT286410 Positive_regulation of Transcription of Fgf13 1 0.62 0 0
155 INT242091 Phosphorylation of STK11 1 0.30 1.93 0
156 INT301374 Localization of Stk11 1 0.23 1.58 0
157 INT286412 Transcription of Fgf13 1 0.64 0 0
158 INT318168 Positive_regulation of Localization of Epo 1 0.01 1.54 0
159 INT322739 Localization of TAOK1 1 0.02 1.24 0
160 INT233573 Negative_regulation of NKX3-1 1 0.42 1.49 0
161 INT198035 Regulation of Negative_regulation of PIK3CA 1 0.15 0.95 0
162 INT164114 Negative_regulation of Localization of 1190002H23Rik 1 0.37 0.11 0
163 INT228609 Negative_regulation of Localization of Epo 1 0.42 0.62 0
164 INT198030 Regulation of Regulation of PIK3CA 1 0.24 1.08 0
165 INT273490 Regulation of Localization of EPO 1 0.45 0.76 0
166 INT258279 Positive_regulation of Binding of Hmgb1 1 0.45 0.26 0
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