GO:0030321

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Name transepithelial chloride transport
Categary Process
Go Slim No
Go Link GO:0030321
Unique Molecular Interactions 45
Total Molecular Interactions 59
Total Single Events 1087
Pain Genes Associated 11

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for transepithelial chloride transport. They are ordered first by their pain relevance and then by number of times they were reported for transepithelial chloride transport. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT210696 Trpv1 Regulation of Slc12a2 1 0.25 1.97 2.58
2 INT162419 Binding of Abpa and Cftr 1 0.04 1.66 1.19
3 INT170832 Cftr Regulation of Scnn1a 2 0.16 1.2 0.67
4 INT170833 Cftr Negative_regulation of Slc10a2 1 0.47 0.31 0.56
5 INT69291 Cftr Positive_regulation of Localization of Slc4a8 1 0.04 0.38 0.51
6 INT117482 CFTR Negative_regulation of THRB 1 0.01 0.15 0.51
7 INT95469 P2ry6 Positive_regulation of Positive_regulation of Pdpk1 1 0.15 0 0.46
8 INT341623 Binding of CFTR and CTRC 1 0.35 1.22 0.46
9 INT341624 Binding of CFTR and PRSS1 1 0.39 1.01 0.45
10 INT352547 Binding of CFTR and DMD 1 0.01 1.42 0.35
11 INT243151 P2ry4 Positive_regulation of P2rx6 1 0.00 0 0.3
12 INT310696 Tlr4 Positive_regulation of Positive_regulation of Cftr 1 0.16 0.74 0.28
13 INT196695 Prkaca Positive_regulation of CFTR 1 0.46 0.13 0.27
14 INT274697 Binding of CFTR and Cftr 1 0.08 0.69 0.27
15 INT109846 Binding of P2RX3 and P2RY4 1 0.40 0 0.25
16 INT170834 Cftr Regulation of Slc10a2 1 0.58 0.37 0.22
17 INT196635 CFTR Positive_regulation of Gene_expression of CCL5 1 0.07 0.44 0.21
18 INT196610 IFNG Negative_regulation of CFTR 1 0.17 0.21 0.19
19 INT267660 CFTR Regulation of Gene_expression of P2RX2 1 0.25 0.51 0.18
20 INT249897 Cysltr1 Positive_regulation of P2ry4 1 0.01 0.7 0.17
21 INT249895 Ltc4s Positive_regulation of P2ry4 1 0.00 0.71 0.17
22 INT196606 IFNG Positive_regulation of CFTR 1 0.16 0.45 0.16
23 INT127206 Negative_regulation of Cftr Negative_regulation of Positive_regulation of Mcf2l 1 0.16 0.62 0.16
24 INT196608 TNF Negative_regulation of CFTR 1 0.16 0.11 0.14
25 INT239790 SLC12A5 Regulation of SLC12A2 1 0.11 0.08 0.13
26 INT257511 Regulation of Binding of Slc12a2 and Slc4a4 1 0.02 0.16 0.06
27 INT216545 Gene_expression of Cftr Negative_regulation of Kcnma1 1 0.00 0.59 0.06
28 INT257510 Binding of Slc12a2 and Slc4a4 1 0.01 0.16 0.06
29 INT246206 Binding of P2ry2 and P2ry4 1 0.12 0 0.05
30 INT196639 Negative_regulation of NA Negative_regulation of Transcription of CFTR 1 0.02 0.63 0.03
31 INT213585 Binding of CFTR and FLNA 1 0.14 0.11 0.03
32 INT310694 Tlr4 Positive_regulation of Cftr 1 0.16 0.34 0.03
33 INT254434 Binding of Lrp5 and Best1 3 0.29 2.53 0
34 INT308747 Binding of Cftr and Prkag1 1 0.02 0 0
35 INT342378 Binding of Vdr and Best1 1 0.05 0.4 0
36 INT342383 Binding of Srp14 and Best1 1 0.00 0.56 0
37 INT289836 BEST1 Positive_regulation of Gene_expression of Car2 1 0.03 0.08 0
38 INT254435 Binding of Esr1 and Best1 1 0.21 0.06 0
39 INT254432 Binding of Best1 and Sost 1 0.12 0.69 0
40 INT247030 Prkaca Regulation of Positive_regulation of Cftr 1 0.05 0 0
41 INT341728 Pth Positive_regulation of Best1 1 0.06 0.43 0
42 INT342386 Binding of CALCR and Best1 1 0.01 0.96 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for transepithelial chloride transport. They are ordered first by their pain relevance and then by number of times they were reported in transepithelial chloride transport. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT103842 Gene_expression of Cftr 53 0.78 59.59 21.82
2 INT91360 Negative_regulation of Slc12a2 16 0.54 10.46 12.89
3 INT84307 Binding of Cftr 31 0.47 26.19 12.8
4 INT127009 Positive_regulation of Phosphorylation of Slc12a2 5 0.70 5.3 9.9
5 INT119892 Gene_expression of Cftr 54 0.77 23.76 9.73
6 INT127010 Phosphorylation of Slc12a2 6 0.82 4.68 9.66
7 INT77282 Positive_regulation of Cftr 23 0.69 21.8 9.65
8 INT101891 Negative_regulation of Cftr 25 0.58 24.09 9.55
9 INT127008 Positive_regulation of Slc12a2 2 0.70 4.73 7.61
10 INT138802 Gene_expression of CFTR 36 0.70 18.8 7.02
11 INT69289 Negative_regulation of Cftr 44 0.57 13.28 6.97
12 INT86119 Regulation of Cftr 13 0.45 14.08 5.75
13 INT151102 Positive_regulation of CFTR 22 0.61 15.27 5.12
14 INT146488 Gene_expression of Slc12a2 16 0.73 4.63 5.11
15 INT89114 Binding of Cftr 13 0.37 11.29 4.99
16 INT130203 Gene_expression of P2ry4 14 0.50 8.79 4.82
17 INT170757 Positive_regulation of Gene_expression of Cftr 3 0.51 11.41 4.75
18 INT169756 Binding of CFTR 9 0.35 9.65 4.55
19 INT48993 Positive_regulation of Cftr 17 0.57 6.02 4.12
20 INT89113 Regulation of Cftr 11 0.62 6.83 4.01
21 INT151099 Negative_regulation of CFTR 12 0.59 10.28 3.79
22 INT215575 Gene_expression of P2ry6 10 0.64 3.43 3.72
23 INT118644 Regulation of Slc12a2 5 0.45 2.43 3.6
24 INT115402 Gene_expression of P2ry4 8 0.71 3.12 3.15
25 INT130202 Negative_regulation of Gene_expression of P2ry4 3 0.15 3.89 3.14
26 INT69290 Localization of Cftr 11 0.75 3.69 2.52
27 INT127007 Positive_regulation of Positive_regulation of Slc12a2 2 0.70 1.42 2.46
28 INT211970 Negative_regulation of Best1 49 0.14 37.33 2.32
29 INT86315 Transcription of Cftr 7 0.53 4.24 2.3
30 INT202522 Negative_regulation of Gene_expression of Cftr 11 0.57 5.9 2.24
31 INT215593 Binding of P2ry6 1 0.31 2.53 2.09
32 INT124355 Negative_regulation of BEST1 11 0.19 6.13 2.04
33 INT166710 Positive_regulation of Gene_expression of CFTR 9 0.46 3.72 2.03
34 INT119891 Regulation of Gene_expression of Cftr 4 0.59 2.67 1.98
35 INT215580 Localization of P2ry4 2 0.42 2.86 1.94
36 INT38268 Positive_regulation of BEST1 16 0.17 14.54 1.93
37 INT151101 Regulation of CFTR 4 0.62 3.69 1.89
38 INT130204 Positive_regulation of Gene_expression of P2ry4 2 0.00 2.73 1.79
39 INT210693 Positive_regulation of Gene_expression of Slc12a2 5 0.46 1.3 1.77
40 INT227759 Gene_expression of Best1 26 0.42 20.36 1.73
41 INT84308 Localization of Cftr 12 0.75 6.16 1.65
42 INT24863 Negative_regulation of SLC12A2 12 0.44 1.85 1.61
43 INT95465 Positive_regulation of P2ry6 4 0.57 2.06 1.61
44 INT114862 Gene_expression of BEST1 16 0.65 12.14 1.53
45 INT117710 Binding of Slc12a2 4 0.19 0.13 1.48
46 INT109850 Gene_expression of P2RY4 8 0.65 2.05 1.47
47 INT152223 Binding of BEST1 10 0.29 6.67 1.46
48 INT211969 Positive_regulation of Best1 34 0.11 14.92 1.44
49 INT108281 Negative_regulation of Binding of Cftr 4 0.43 3.1 1.38
50 INT139625 Regulation of Gene_expression of Cftr 5 0.50 3.59 1.32
51 INT196675 Localization of CFTR 4 0.64 1.95 1.19
52 INT215595 Regulation of P2ry6 1 0.22 1.4 1.12
53 INT117967 Binding of P2ry4 4 0.36 0.24 1.1
54 INT108241 Negative_regulation of P2ry4 3 0.27 1.78 1.1
55 INT127004 Regulation of Phosphorylation of Slc12a2 1 0.54 0.35 1.1
56 INT196863 Positive_regulation of P2ry4 4 0.27 1.87 1.07
57 INT160022 Transcription of Slc12a2 2 0.53 0.75 0.97
58 INT108242 Regulation of P2ry4 3 0.32 0.81 0.88
59 INT216648 Transcription of P2ry6 2 0.33 1.27 0.88
60 INT86314 Regulation of Transcription of Cftr 2 0.33 1.81 0.83
61 INT61290 Regulation of Phosphorylation of CFTR 1 0.44 0.25 0.81
62 INT274693 Positive_regulation of Gene_expression of Cftr 6 0.49 2.93 0.8
63 INT61291 Phosphorylation of CFTR 1 0.80 0.25 0.8
64 INT196682 Negative_regulation of Gene_expression of CFTR 6 0.34 1.96 0.73
65 INT151100 Negative_regulation of Positive_regulation of CFTR 1 0.43 1.11 0.73
66 INT216652 Transcription of P2ry4 1 0.28 1.57 0.7
67 INT127204 Negative_regulation of Positive_regulation of Cftr 1 0.43 1.9 0.69
68 INT211972 Regulation of Best1 18 0.33 12.04 0.67
69 INT215828 Regulation of Binding of Cftr 2 0.33 1.56 0.66
70 INT250351 Positive_regulation of Gene_expression of Best1 5 0.27 3.14 0.65
71 INT103841 Negative_regulation of Gene_expression of Cftr 3 0.43 1.93 0.63
72 INT151098 Positive_regulation of Positive_regulation of CFTR 2 0.50 0.9 0.63
73 INT216650 Regulation of P2ry4 1 0.14 0.69 0.62
74 INT11225 Positive_regulation of SLC12A2 3 0.45 1.1 0.6
75 INT170759 Positive_regulation of Binding of Cftr 2 0.50 1.82 0.6
76 INT72634 Positive_regulation of P2ry4 2 0.46 0.09 0.56
77 INT348872 Positive_regulation of Regulation of Cftr 1 0.34 1.3 0.55
78 INT160019 Regulation of Transcription of Slc12a2 1 0.26 0.41 0.46
79 INT328606 Regulation of Regulation of Slc12a2 1 0.10 0 0.42
80 INT310689 Positive_regulation of Negative_regulation of Cftr 1 0.47 1.41 0.4
81 INT99845 Localization of P2ry4 1 0.73 0 0.39
82 INT211968 Localization of Best1 11 0.40 9.33 0.38
83 INT226184 Protein_catabolism of Cftr 3 0.87 1.52 0.38
84 INT170758 Positive_regulation of Localization of Cftr 2 0.50 2.4 0.35
85 INT217013 Transcription of P2RY4 1 0.21 0.26 0.35
86 INT211971 Binding of Best1 16 0.22 7.73 0.33
87 INT24862 Negative_regulation of Negative_regulation of SLC12A2 1 0.23 0 0.33
88 INT170756 Negative_regulation of Localization of Cftr 1 0.42 1.74 0.31
89 INT267666 Regulation of Localization of CFTR 1 0.22 0.39 0.3
90 INT239793 Localization of SLC12A2 1 0.57 0.14 0.28
91 INT120959 Protein_catabolism of CFTR 1 0.03 0.14 0.28
92 INT132710 Negative_regulation of Regulation of Cftr 1 0.06 0.1 0.27
93 INT196688 Positive_regulation of Binding of CFTR 1 0.26 0.33 0.24
94 INT50948 Gene_expression of SLC12A2 6 0.59 4.55 0.22
95 INT215569 Negative_regulation of P2ry6 1 0.11 0 0.2
96 INT308734 Transcription of Cftr 1 0.68 0.75 0.2
97 INT282127 Regulation of Regulation of Best1 1 0.15 1.67 0.18
98 INT174812 Regulation of BEST1 3 0.07 2.4 0.17
99 INT183817 Localization of BEST1 6 0.26 5.22 0.16
100 INT196681 Negative_regulation of Localization of CFTR 1 0.34 0.18 0.15
101 INT109847 Binding of P2RY4 1 0.36 0 0.12
102 INT310692 Positive_regulation of Protein_catabolism of Cftr 1 0.44 0.46 0.12
103 INT196672 Positive_regulation of Localization of CFTR 1 0.41 0 0.1
104 INT347555 Positive_regulation of Localization of Cftr 1 0.14 0.63 0.09
105 INT308732 Regulation of Transcription of Cftr 1 0.44 0.18 0.09
106 INT308735 Negative_regulation of Positive_regulation of Cftr 1 0.42 0.15 0.08
107 INT196673 Regulation of Gene_expression of CFTR 1 0.36 0.62 0.08
108 INT292542 Localization of Slc12a2 1 0.66 0 0.07
109 INT274694 Negative_regulation of Binding of Cftr 1 0.35 0.19 0.05
110 INT239797 Regulation of SLC12A2 1 0.34 0.1 0.04
111 INT196683 Negative_regulation of Transcription of CFTR 1 0.22 0.61 0.03
112 INT196685 Transcription of CFTR 1 0.37 0.6 0.03
113 INT243134 Positive_regulation of Positive_regulation of P2ry4 1 0.20 0 0.03
114 INT227758 Positive_regulation of Localization of Best1 3 0.07 1.95 0
115 INT216614 Positive_regulation of Gene_expression of P2ry4 1 0.29 0.08 0
116 INT308731 Phosphorylation of Cftr 1 0.62 0 0
117 INT341725 Regulation of Positive_regulation of Best1 1 0.07 0.26 0
118 INT216564 Regulation of Negative_regulation of Cftr 1 0.24 0.12 0
119 INT327449 Positive_regulation of Negative_regulation of BEST1 1 0.09 0.93 0
120 INT216608 Positive_regulation of Gene_expression of P2ry6 1 0.23 0.22 0
121 INT215579 Localization of P2ry6 1 0.19 0.18 0
122 INT335854 Negative_regulation of Localization of Best1 1 0.06 0.33 0
123 INT234345 Positive_regulation of P2RY4 1 0.44 0.3 0
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