GO:0030326

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Name embryonic limb morphogenesis
Categary Process
Go Slim No
Go Link GO:0030326
Unique Molecular Interactions 444
Total Molecular Interactions 581
Total Single Events 3809
Pain Genes Associated 56

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for embryonic limb morphogenesis. They are ordered first by their pain relevance and then by number of times they were reported for embryonic limb morphogenesis. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT93470 Notch1 Positive_regulation of Localization of Prkcg 2 0.09 0.31 1.65
2 INT111076 Psen1 Regulation of Psenen 1 0.17 0.76 1.58
3 INT65373 Notch1 Regulation of Oprd1 1 0.09 0 1.16
4 INT275097 Twist1 Regulation of Ltp 1 0.01 0.37 0.96
5 INT165941 Bmp7 Positive_regulation of Penk 1 0.28 0.43 0.95
6 INT165942 Bmp7 Positive_regulation of Transcription of Pomc 1 0.29 0.43 0.95
7 INT165940 Bmp7 Positive_regulation of Pomc 1 0.29 0.43 0.95
8 INT254242 TNF Positive_regulation of Gene_expression of DKK1 1 0.14 1.24 0.91
9 INT140985 Gli3 Regulation of Ihh 1 0.29 0.85 0.85
10 INT278690 LEF1 Negative_regulation of Gene_expression of IK 1 0.00 0.66 0.83
11 INT278697 LEF1 Negative_regulation of STAT6 1 0.00 0.44 0.78
12 INT146780 Positive_regulation of Fgfr1 Positive_regulation of Mapk14 1 0.34 0.95 0.77
13 INT64067 Tp63 Negative_regulation of Localization of Gh1 1 0.08 0.07 0.76
14 INT314203 Nos2 Positive_regulation of Gli3 1 0.19 1.27 0.73
15 INT243626 Twist1 Regulation of Hand1 1 0.15 1.55 0.72
16 INT320634 Positive_regulation of MAPK1 Regulation of PBX2 1 0.03 1.21 0.7
17 INT64070 Tp63 Regulation of Ghrh 1 0.04 0.06 0.69
18 INT64068 Tp63 Regulation of Fdft1 1 0.00 0.06 0.69
19 INT68561 Binding of Gli3 and Ust 1 0.01 0.68 0.68
20 INT231533 IL4 Positive_regulation of LRP5 1 0.00 0.87 0.67
21 INT259776 Fbn2 Regulation of Negative_regulation of Agtr1a 1 0.00 1.42 0.66
22 INT243639 Twist1 Negative_regulation of Gene_expression of Il2 1 0.24 1.28 0.65
23 INT139079 Tnip1 Negative_regulation of Ptch1 1 0.20 0.63 0.62
24 INT102864 Prkaca Regulation of Twist1 1 0.48 0.05 0.58
25 INT278227 Binding of MBNL1 and SNRNP70 1 0.01 2.05 0.54
26 INT278228 Binding of MBNL1 and NOS3 1 0.05 2.06 0.54
27 INT353978 Lmx1b Regulation of Gene_expression of Pet1 1 0.31 0.21 0.53
28 INT278105 Negative_regulation of TP63 Negative_regulation of Binding of P2RX7 1 0.00 0 0.51
29 INT165078 Binding of CTSB and Notch1 1 0.00 1.08 0.48
30 INT102364 BRD1 Positive_regulation of Twist1 1 0.00 0 0.47
31 INT117531 Twist1 Regulation of CSAD 1 0.00 0.85 0.47
32 INT102862 Prkaca Regulation of Phosphorylation of Twist1 1 0.19 0.1 0.42
33 INT261652 Binding of MAPK1 and PSEN1 1 0.22 1.25 0.41
34 INT237454 Binding of STAR and GREM1 1 0.00 0.44 0.4
35 INT300609 Binding of Ctnnb1 and Wnt2 1 0.02 0.25 0.37
36 INT168202 Msx1 Negative_regulation of Gene_expression of Mc1r 1 0.21 0.49 0.35
37 INT124378 Prodh2 Positive_regulation of Ctnnb1 1 0.00 0.59 0.35
38 INT243627 Twist1 Regulation of Gene_expression of Ik 1 0.01 0.13 0.34
39 INT85909 Binding of Oprm1 and GREM1 1 0.00 0 0.32
40 INT243622 Twist1 Regulation of Jak2 1 0.30 0.2 0.32
41 INT243641 Twist1 Positive_regulation of Socs1 1 0.14 0.13 0.31
42 INT243634 Twist1 Regulation of Socs1 1 0.14 0.13 0.31
43 INT146893 TNF Negative_regulation of Dkk1 1 0.01 1.27 0.3
44 INT243625 Stat4 Positive_regulation of Gene_expression of Twist1 1 0.39 0.75 0.3
45 INT243630 Il12a Positive_regulation of Gene_expression of Twist1 1 0.18 0.69 0.3
46 INT75056 Binding of MC1R and Msx1 1 0.00 0.17 0.29
47 INT162599 Wnt5a Regulation of Gene_expression of IL4I1 1 0.00 0.1 0.28
48 INT297547 Pou3f3 Regulation of Psen1 1 0.00 0.41 0.25
49 INT118461 Bmp7 Positive_regulation of Th 1 0.31 0.06 0.25
50 INT168203 Binding of Mc1r and Msx1 1 0.19 0.64 0.25
51 INT275092 Twist1 Regulation of stm 1 0.00 0 0.25
52 INT243640 Binding of Twist1 and Stub1 1 0.08 0.34 0.24
53 INT194578 Binding of HOXA10 and BTG3 1 0.00 0.66 0.24
54 INT235125 PDE2A Negative_regulation of Twist1 1 0.00 0.99 0.24
55 INT353981 Gene_expression of Pet1 Positive_regulation of Lmx1b 1 0.53 0 0.23
56 INT296372 Binding of IDUA and ACD 1 0.03 2.72 0.23
57 INT26185 Positive_regulation of Binding of GREM1 and Cyth2 1 0.00 0 0.22
58 INT9717 Binding of Egf and Fgfr1 1 0.15 0 0.22
59 INT26186 Binding of GREM1 and Cyth2 1 0.00 0 0.22
60 INT20310 Binding of Hnf1a and Positive_regulation of Transcription of Cyp2e1 1 0.02 0 0.21
61 INT132680 HNF1A Positive_regulation of Gene_expression of UGT1A6 1 0.30 0.08 0.21
62 INT257728 Binding of Pbx2 and Vgf 1 0.42 0.18 0.21
63 INT132679 HNF1A Regulation of Gene_expression of UGT1A6 1 0.16 0.08 0.21
64 INT75057 Binding of POMC and Msx1 2 0.39 0.6 0.2
65 INT297544 Pou3f3 Regulation of Notch1 1 0.06 0.41 0.2
66 INT256629 Binding of Ptch1 and Shh 7 0.42 4.22 0.19
67 INT251665 LRP5 Negative_regulation of Ache 1 0.31 0.39 0.19
68 INT209581 Twist1 Positive_regulation of Gene_expression of VEGFA 6 0.06 7.86 0.16
69 INT244843 Lbx1 Negative_regulation of Hoxd10 1 0.02 0.09 0.16
70 INT219601 Pde4a Negative_regulation of Twist1 1 0.10 0 0.16
71 INT219598 Pde4a Negative_regulation of Gene_expression of Twist1 1 0.10 0 0.16
72 INT316052 Notch1 Regulation of Binding of Cd8a 1 0.01 0.86 0.15
73 INT316053 Notch1 Regulation of Binding of Cd4 1 0.02 0.86 0.15
74 INT97547 KITLG Negative_regulation of Msx1 1 0.00 0.08 0.15
75 INT316050 Binding of Notch1 and Regulation of Binding of Cd8a 1 0.01 0.86 0.15
76 INT97542 Pomc Negative_regulation of Msx1 1 0.13 0.07 0.15
77 INT316051 Binding of Notch1 and Regulation of Binding of Cd4 1 0.02 0.86 0.15
78 INT97545 Gtf3a Negative_regulation of Msx1 1 0.02 0.08 0.15
79 INT213551 Proc Regulation of Bmp7 1 0.00 0.15 0.14
80 INT88410 BMP7 Negative_regulation of CDK2 1 0.35 0 0.14
81 INT94763 PSEN2 Regulation of Positive_regulation of App 1 0.11 0.72 0.14
82 INT184704 Binding of Prrx2 and Sr1 1 0.21 1.65 0.13
83 INT251115 Positive_regulation of Binding of AR and Ctnnb1 1 0.01 1.02 0.13
84 INT301414 Binding of Enpp2 and Twist1 1 0.08 1.26 0.13
85 INT345343 PTCH1 Regulation of Negative_regulation of SMO 1 0.09 2.3 0.13
86 INT214150 Binding of Mc3r and Msx1 1 0.03 0.5 0.12
87 INT243642 Binding of Nfatc1 and Twist1 1 0.08 0.23 0.12
88 INT297543 Neurod1 Regulation of Psen1 1 0.00 0.2 0.12
89 INT251114 Binding of AR and Ctnnb1 1 0.01 1 0.12
90 INT214152 Binding of Mc4r and Msx1 1 0.03 0.24 0.11
91 INT273018 Binding of FGF9 and PDE1A 1 0.18 0.3 0.11
92 INT273020 Binding of FGF9 and PDE11A 1 0.22 0.3 0.11
93 INT297546 Neurod1 Regulation of Notch1 1 0.05 0.2 0.1
94 INT302287 Twist1 Positive_regulation of Positive_regulation of PTGER2 1 0.03 1.16 0.1
95 INT302288 Twist1 Positive_regulation of PTGER2 1 0.03 1.16 0.1
96 INT233510 Wnt5a Positive_regulation of Gene_expression of Il12a 1 0.03 0.33 0.1
97 INT352555 DKK1 Positive_regulation of Wnt2 1 0.01 0.25 0.1
98 INT262751 Binding of PTCH1 and SMO 1 0.25 1.29 0.1
99 INT278217 Binding of Ciita and Notch1 1 0.41 0.22 0.09
100 INT214168 Msx1 Positive_regulation of Gene_expression of DST 1 0.00 0.13 0.09
101 INT129624 Bmp7 Positive_regulation of Gene_expression of Id2 1 0.26 0.31 0.08
102 INT270457 Binding of Ptch1 and Gli1 1 0.02 1.3 0.08
103 INT211960 Wnt5a Positive_regulation of Car2 1 0.13 0.38 0.08
104 INT340505 Binding of Twist1 and Mgat4b 1 0.01 0.45 0.08
105 INT129623 Bmp7 Positive_regulation of Gene_expression of Id3 1 0.37 0.31 0.08
106 INT234222 PSEN1 Regulation of Gene_expression of NOTCH1 1 0.03 0 0.08
107 INT129625 Id2 Positive_regulation of Gene_expression of Bmp7 1 0.24 0.31 0.08
108 INT270464 Binding of Shh and Smo 1 0.07 1.3 0.08
109 INT350909 Binding of Pcsk4 and Twist1 1 0.02 1.91 0.08
110 INT129622 Id3 Positive_regulation of Gene_expression of Bmp7 1 0.25 0.31 0.08
111 INT288374 Binding of MLANA and Msx1 1 0.09 0 0.08
112 INT193959 Psen1 Regulation of App 1 0.40 0.58 0.08
113 INT205119 Binding of HIVEP1 and GREM1 1 0.00 2.24 0.08
114 INT290906 Shh Positive_regulation of Egfr 1 0.23 0 0.08
115 INT350908 Binding of Bcl2 and Twist1 1 0.04 1.9 0.08
116 INT228501 Binding of AAVS1 and Fgfr1 1 0.01 0.57 0.07
117 INT129627 Bmp7 Positive_regulation of Id2 1 0.24 0.25 0.07
118 INT335890 Binding of Dkk1 and Lrp4 1 0.37 0.64 0.07
119 INT335886 Binding of Sost and Lrp4 1 0.28 0.65 0.07
120 INT129626 Bmp7 Positive_regulation of Id3 1 0.25 0.25 0.07
121 INT297246 Binding of Notch1 and Ncstn 1 0.04 0.32 0.07
122 INT298349 HES3 Positive_regulation of Shh 1 0.12 0.14 0.07
123 INT327871 Binding of Notch1 and Postn 1 0.38 1.42 0.07
124 INT297244 Regulation of Binding of Notch1 and Ncstn 1 0.05 0.32 0.07
125 INT193954 Binding of App and Psen1 3 0.38 0.88 0.06
126 INT290905 Gene_expression of Shh Positive_regulation of Gene_expression of Angpt1 1 0.14 0 0.06
127 INT312636 Negative_regulation of Binding of Musk and Lrp4 1 0.21 0.32 0.06
128 INT273288 Psen1 Regulation of Prdx2 1 0.01 0.7 0.06
129 INT349886 Negative_regulation of Binding of Pcyt1a and Twist1 1 0.02 1.21 0.06
130 INT312639 Binding of Musk and Lrp4 1 0.23 0.91 0.06
131 INT262214 Binding of Msx2 and Nr1i2 1 0.19 0.55 0.06
132 INT201973 Bmp7 Positive_regulation of ap 1 0.00 0.18 0.06
133 INT243637 Il12a Positive_regulation of Transcription of Twist1 1 0.18 0.12 0.06
134 INT312632 Binding of Agrn and Lrp4 1 0.17 0.32 0.06
135 INT349887 Binding of Pcyt1a and Twist1 1 0.02 1.21 0.06
136 INT262173 Binding of Msx2 and Ep300 1 0.07 0.55 0.06
137 INT118462 BMP7 Regulation of Bmp7 1 0.19 0 0.06
138 INT273353 Pde4d Regulation of Gene_expression of Twist1 1 0.26 0.25 0.05
139 INT214146 Msx1 Positive_regulation of Gene_expression of Nucb2 1 0.05 0.19 0.05
140 INT321891 Dkk1 Negative_regulation of Wnt2 1 0.12 0.94 0.05
141 INT193967 Binding of PSEN1 and Psen1 1 0.41 1.2 0.05
142 INT193970 Binding of PSEN1 and Psen2 1 0.36 2.06 0.05
143 INT243633 Il23a Positive_regulation of Gene_expression of Twist1 1 0.14 0.11 0.05
144 INT210261 Bmp4 Regulation of Gene_expression of Tff3 1 0.64 0 0.05
145 INT242167 Binding of Dkk1 and Kremen2 1 0.01 0.06 0.04
146 INT335017 Fgf23 Positive_regulation of Fgfr1 1 0.23 0.59 0.04
147 INT233849 Twist1 Positive_regulation of Snai2 1 0.07 0.58 0.04
148 INT233852 Twist1 Positive_regulation of Snai1 1 0.02 0.58 0.04
149 INT349314 Binding of Notch1 and Notch3 1 0.11 0.67 0.04
150 INT275090 Twist1 Positive_regulation of Gene_expression of Pde5a 1 0.02 0.62 0.04
151 INT213563 Binding of Ctnnd2 and Shh 1 0.27 0.09 0.04
152 INT233851 Twist1 Positive_regulation of Zeb1 1 0.06 0.58 0.04
153 INT275095 Twist1 Positive_regulation of Pde5a 1 0.03 0.62 0.04
154 INT270459 Binding of Shh and Gli1 1 0.02 0.65 0.04
155 INT356101 App Regulation of Negative_regulation of Psen1 1 0.23 0.31 0.04
156 INT233854 Twist1 Positive_regulation of Itk 1 0.03 0.58 0.04
157 INT321890 Slc3a2 Regulation of Dkk1 1 0.01 0.93 0.04
158 INT331477 PSEN2 Regulation of Gene_expression of Psen1 1 0.00 0.15 0.03
159 INT289101 Binding of KCNA1 and LEF1 1 0.00 2.58 0.03
160 INT352014 Shh Positive_regulation of Gene_expression of Pax1 1 0.29 0.07 0.03
161 INT255756 Ptch1 Positive_regulation of Phosphorylation of Pik3r1 1 0.16 1.08 0.03
162 INT354896 Binding of Psen2 and Fancd2 1 0.04 0.75 0.03
163 INT243636 Stat1 Positive_regulation of Gene_expression of Twist1 1 0.46 0.05 0.03
164 INT287234 PDLIM7 Positive_regulation of Gene_expression of BMP7 1 0.14 0.12 0.03
165 INT255733 Ptch1 Positive_regulation of Pik3r1 1 0.16 1.08 0.03
166 INT301413 Positive_regulation of Binding of Enpp2 and Twist1 1 0.11 0.18 0.03
167 INT311655 Shh Positive_regulation of Gene_expression of Fgf8 1 0.31 0.18 0.03
168 INT301415 Positive_regulation of Binding of Twist1 and IL19 1 0.11 0.18 0.03
169 INT270462 Shh Positive_regulation of Ccnd1 1 0.10 0.6 0.03
170 INT327876 Postn Regulation of Gene_expression of Notch1 1 0.56 0.92 0.03
171 INT167565 Binding of ERG and LRP5 1 0.02 0.94 0.03
172 INT331478 Psen1 Regulation of Gene_expression of PSEN2 1 0.00 0.15 0.03
173 INT213559 Binding of Egf and Shh 1 0.17 0.07 0.03
174 INT301416 Binding of Twist1 and IL19 1 0.08 0.18 0.03
175 INT301408 Positive_regulation of Binding of Enpp1 and Twist1 1 0.06 0.18 0.03
176 INT301406 Binding of Enpp1 and Twist1 1 0.04 0.18 0.03
177 INT235800 Twist1 Positive_regulation of VEGFA 1 0.02 0.62 0.03
178 INT205611 Gm6668 Negative_regulation of Fgfr1 1 0.01 1.59 0
179 INT348532 TP63 Positive_regulation of CASP3 1 0.04 0.55 0
180 INT233276 Cdkn1a Regulation of Hoxa10 1 0.12 0.26 0
181 INT233280 Binding of PBX1 and Emx2 1 0.19 0.68 0
182 INT193946 Binding of Notch1 and Positive_regulation of Psen1 1 0.03 0.06 0
183 INT292882 Binding of S100A12 and TP63 1 0.06 0.51 0
184 INT267117 Lmx1b Regulation of Col7a1 1 0.02 1.29 0
185 INT290910 Pkm2 Negative_regulation of Shh 1 0.07 0.06 0
186 INT343744 mn Negative_regulation of Regulation of Wnt7a 1 0.01 0.1 0
187 INT284095 HNF1A Positive_regulation of TIMP3 1 0.38 2.3 0
188 INT255758 Ptch1 Positive_regulation of Akt1 1 0.21 1.14 0
189 INT284092 HNF1A Positive_regulation of FGD2 1 0.15 1.16 0
190 INT293869 Binding of COL2A1 and GREM1 1 0.00 1.11 0
191 INT307602 Binding of ACHE and LRP5 1 0.01 0.17 0
192 INT209580 Twist1 Positive_regulation of Localization of VEGFA 1 0.05 0.53 0
193 INT280164 Twist1 Negative_regulation of Mod2 1 0.06 1.76 0
194 INT205963 GLI1 Positive_regulation of Negative_regulation of SHH 1 0.22 0.58 0
195 INT337402 LEF1 Positive_regulation of E2F1 1 0.11 0 0
196 INT314850 Shh Regulation of Atoh7 1 0.45 0.22 0
197 INT327870 Postn Positive_regulation of Gene_expression of Notch1 1 0.37 0.57 0
198 INT255732 Ptch1 Positive_regulation of hs 1 0.06 1.26 0
199 INT297245 Prnp Positive_regulation of Notch1 1 0.21 0.73 0
200 INT193962 Binding of Psen1 and Ncstn 1 0.13 0.08 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for embryonic limb morphogenesis. They are ordered first by their pain relevance and then by number of times they were reported in embryonic limb morphogenesis. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT79395 Gene_expression of Twist1 193 0.77 100.06 26.34
2 INT111073 Gene_expression of Psen1 167 0.76 78.65 15.83
3 INT129883 Gene_expression of Dkk1 56 0.77 45.42 12.52
4 INT111476 Gene_expression of TP63 88 0.76 61.08 11.64
5 INT10874 Negative_regulation of Twist1 89 0.50 36.84 11.32
6 INT91772 Gene_expression of PSEN1 115 0.75 38.12 8.48
7 INT43820 Positive_regulation of Twist1 75 0.59 42.15 8.47
8 INT111069 Regulation of Psen1 19 0.44 7.78 5.87
9 INT60724 Gene_expression of Psen2 30 0.72 27 5.79
10 INT123726 Positive_regulation of Notch1 23 0.70 7.2 5.65
11 INT136664 Positive_regulation of Gene_expression of Twist1 49 0.69 25.91 5.41
12 INT94028 Regulation of Twist1 37 0.44 22.41 5.33
13 INT123422 Gene_expression of Lmx1b 18 0.78 6.93 5.17
14 INT68559 Negative_regulation of Gli3 5 0.37 4.56 4.93
15 INT69217 Gene_expression of Notch1 20 0.78 7.8 4.41
16 INT111156 Negative_regulation of Dkk1 21 0.58 20.08 4.27
17 INT111067 Positive_regulation of Gene_expression of Psen1 32 0.68 21.2 4.19
18 INT109391 Gene_expression of Fgfr1 7 0.56 1.78 3.67
19 INT67726 Gene_expression of Notch1 36 0.75 9.77 3.54
20 INT40368 Positive_regulation of LRP5 5 0.49 3.19 3.51
21 INT141148 Gene_expression of BMP7 24 0.71 14.34 3.44
22 INT12844 Binding of TP63 15 0.47 10.57 3.38
23 INT100295 Gene_expression of Bmp7 27 0.78 14.34 3.3
24 INT211591 Negative_regulation of PSEN1 14 0.57 5.73 3.26
25 INT119218 Positive_regulation of Fgfr1 4 0.58 1.11 3.05
26 INT91761 Gene_expression of PSEN2 38 0.75 22.93 3.03
27 INT193936 Positive_regulation of PSEN1 5 0.58 11.57 2.95
28 INT101567 Gene_expression of Ctnnb1 7 0.64 10.11 2.89
29 INT116540 Binding of Twist1 35 0.48 16.32 2.85
30 INT259760 Localization of Fbn2 5 0.05 5.55 2.85
31 INT139872 Regulation of Notch1 14 0.45 7.69 2.82
32 INT111153 Positive_regulation of Dkk1 13 0.68 10.56 2.58
33 INT259762 Positive_regulation of Fbn2 4 0.05 6.74 2.55
34 INT126581 Positive_regulation of Gli3 6 0.35 1.59 2.48
35 INT163544 Binding of Psen1 40 0.36 15.28 2.42
36 INT32920 Gene_expression of Msx1 19 0.71 4.24 2.42
37 INT188255 Gene_expression of DKK1 19 0.60 12.69 2.39
38 INT55090 Positive_regulation of Wnt7a 13 0.37 2.25 2.2
39 INT50057 Regulation of Notch1 3 0.39 0.87 2.14
40 INT144364 Negative_regulation of Lmx1b 5 0.45 3.35 2.12
41 INT181507 Positive_regulation of Psen1 22 0.49 7.59 2.04
42 INT126374 Gene_expression of Gli3 6 0.77 3.67 2.02
43 INT60723 Localization of Psen2 5 0.68 2.11 2.02
44 INT184676 Transcription of Prrx2 1 0.37 3.64 2.02
45 INT144973 Gene_expression of Shh 9 0.77 4.32 1.96
46 INT193939 Binding of PSEN1 10 0.36 6.16 1.93
47 INT140036 Positive_regulation of Gene_expression of Notch1 6 0.61 2 1.86
48 INT52633 Negative_regulation of Notch1 4 0.42 2.99 1.84
49 INT102861 Phosphorylation of Twist1 6 0.70 0.86 1.81
50 INT208561 Gene_expression of Shh 51 0.78 9.57 1.77
51 INT111070 Negative_regulation of Gene_expression of Psen1 17 0.42 9.47 1.77
52 INT139475 Negative_regulation of DKK1 14 0.52 9.2 1.76
53 INT120088 Gene_expression of Bmp4 37 0.73 13.89 1.73
54 INT176629 Gene_expression of GREM1 9 0.10 6.89 1.66
55 INT123990 Positive_regulation of Ctnnb1 8 0.43 2.85 1.63
56 INT113985 Positive_regulation of TP63 9 0.50 8.79 1.62
57 INT99391 Localization of Ctnnb1 7 0.80 5.84 1.61
58 INT180238 Regulation of Gene_expression of Twist1 13 0.61 4.87 1.59
59 INT344978 Negative_regulation of Gene_expression of Dkk1 1 0.58 4.38 1.59
60 INT6830 Positive_regulation of Notch1 20 0.55 7.91 1.57
61 INT193823 Positive_regulation of Gene_expression of TP63 7 0.18 7.74 1.57
62 INT278715 Gene_expression of LEF1 10 0.33 5.43 1.54
63 INT282434 Regulation of Gene_expression of Psen1 9 0.50 2.85 1.52
64 INT163381 Transcription of Notch1 2 0.69 0.41 1.52
65 INT259766 Positive_regulation of Localization of Fbn2 1 0.03 3.09 1.51
66 INT184683 Gene_expression of Prrx2 1 0.37 7.9 1.5
67 INT278727 Negative_regulation of Gene_expression of LEF1 3 0.11 1.59 1.47
68 INT140245 Binding of Gli3 3 0.36 2.65 1.46
69 INT78646 Regulation of Psen2 4 0.20 1.78 1.42
70 INT321889 Negative_regulation of Dkk1 2 0.38 5.7 1.42
71 INT102860 Positive_regulation of Phosphorylation of Twist1 1 0.35 0.15 1.42
72 INT113151 Positive_regulation of Ptch1 7 0.64 3.8 1.41
73 INT165538 Binding of Bmp7 5 0.37 1.87 1.39
74 INT287241 Positive_regulation of BMP7 10 0.43 2.68 1.38
75 INT10873 Localization of Twist1 21 0.74 10.43 1.37
76 INT219579 Negative_regulation of Gene_expression of Twist1 12 0.43 9.07 1.36
77 INT181509 Negative_regulation of Psen1 17 0.57 11.53 1.35
78 INT110784 Protein_catabolism of Notch1 8 0.21 2.32 1.31
79 INT152951 Negative_regulation of LEF1 5 0.41 3.22 1.31
80 INT353966 Negative_regulation of Gene_expression of Lmx1b 1 0.43 0.16 1.31
81 INT139077 Negative_regulation of Ptch1 5 0.56 5.22 1.29
82 INT243621 Transcription of Twist1 13 0.71 4.08 1.23
83 INT99389 Negative_regulation of Ctnnb1 8 0.45 3.97 1.21
84 INT138726 Positive_regulation of Gene_expression of Msx1 5 0.53 1.73 1.2
85 INT108519 Binding of Lrp6 8 0.44 1.47 1.19
86 INT110780 Localization of Notch1 2 0.06 0.47 1.19
87 INT35095 Negative_regulation of Notch2 3 0.36 0.06 1.15
88 INT253191 Positive_regulation of Gene_expression of Shh 2 0.66 2.57 1.14
89 INT278117 Negative_regulation of TP63 5 0.32 3.38 1.13
90 INT123727 Negative_regulation of Notch1 6 0.21 1.22 1.11
91 INT101570 Positive_regulation of Gene_expression of Ctnnb1 1 0.58 5.7 1.07
92 INT165530 Positive_regulation of Shh 4 0.69 1.21 1.05
93 INT165338 Binding of Dkk1 4 0.37 3.64 1.04
94 INT127647 Regulation of Wnt7a 3 0.07 1.28 1.01
95 INT184698 Positive_regulation of Prrx2 1 0.38 3.21 1.01
96 INT78645 Negative_regulation of Gene_expression of Psen2 1 0.14 0.13 1.01
97 INT6833 Binding of Notch1 4 0.36 0.05 0.94
98 INT91771 Positive_regulation of Gene_expression of PSEN1 13 0.49 8.93 0.93
99 INT71601 Positive_regulation of ACD 11 0.60 6.55 0.9
100 INT101566 Negative_regulation of Gene_expression of Ctnnb1 1 0.35 2.28 0.88
101 INT312362 Gene_expression of PBX1 1 0.56 4.48 0.87
102 INT142122 Regulation of Gene_expression of Bmp4 5 0.43 2.69 0.86
103 INT135299 Binding of PTCH1 10 0.48 12.16 0.84
104 INT266562 Gene_expression of Fbn2 1 0.05 0.93 0.84
105 INT266563 Positive_regulation of Gene_expression of Fbn2 1 0.04 0.93 0.84
106 INT165337 Regulation of Dkk1 3 0.44 2.16 0.83
107 INT78647 Positive_regulation of Localization of Psen2 1 0.16 0.14 0.83
108 INT278710 Phosphorylation of LEF1 1 0.05 0.76 0.82
109 INT72334 Negative_regulation of LRP5 7 0.35 1.71 0.81
110 INT312364 Positive_regulation of PBX1 1 0.43 4.69 0.81
111 INT210247 Positive_regulation of Bmp4 6 0.65 4.36 0.8
112 INT237406 Positive_regulation of Binding of Psen1 1 0.29 0 0.8
113 INT94756 Positive_regulation of PSEN2 8 0.49 4.59 0.77
114 INT188251 Localization of DKK1 6 0.50 3.26 0.77
115 INT286313 Transcription of Psen1 9 0.70 2.26 0.76
116 INT44293 Regulation of TP63 6 0.24 2.88 0.76
117 INT242131 Localization of Dkk1 5 0.79 6 0.76
118 INT193849 Positive_regulation of Gene_expression of Psen2 5 0.44 4.92 0.76
119 INT141150 Localization of BMP7 4 0.56 2.84 0.76
120 INT259763 Regulation of Fbn2 1 0.02 1.47 0.76
121 INT103233 Transcription of Pbx2 1 0.67 0.42 0.75
122 INT40369 Gene_expression of LRP5 8 0.55 5.63 0.74
123 INT142416 Binding of Ptch1 6 0.34 4.92 0.74
124 INT78649 Binding of Psen2 7 0.36 5.9 0.73
125 INT95617 Regulation of Msx1 2 0.56 1.05 0.73
126 INT57510 Regulation of Notch2 1 0.05 0 0.73
127 INT78648 Regulation of Binding of Psen2 1 0.14 0.2 0.73
128 INT344975 Regulation of Gene_expression of Dkk1 1 0.44 3.44 0.73
129 INT129882 Positive_regulation of Gene_expression of Dkk1 4 0.69 4.62 0.72
130 INT166537 Localization of Fgfr1 5 0.40 2.69 0.69
131 INT140037 Positive_regulation of Positive_regulation of Notch1 2 0.22 1.34 0.69
132 INT171747 Gene_expression of ACD 4 0.57 4.44 0.68
133 INT68560 Regulation of Gli3 3 0.18 1.51 0.68
134 INT231558 Regulation of LRP5 2 0.24 1.02 0.68
135 INT153257 Regulation of Ptch1 6 0.36 5.92 0.67
136 INT173508 Negative_regulation of Fgfr1 4 0.55 5.08 0.66
137 INT75043 Binding of Msx1 6 0.35 2.36 0.65
138 INT28958 Negative_regulation of Wnt7a 3 0.45 0.49 0.65
139 INT99390 Regulation of Ctnnb1 4 0.62 3.12 0.64
140 INT96422 Gene_expression of Bmp4 18 0.69 3.26 0.63
141 INT91765 Positive_regulation of Gene_expression of PSEN2 8 0.49 4.57 0.63
142 INT146775 Phosphorylation of Fgfr1 1 0.53 0.8 0.62
143 INT100294 Positive_regulation of Gene_expression of Bmp7 8 0.46 5.41 0.61
144 INT243616 Positive_regulation of Transcription of Twist1 6 0.69 2.09 0.6
145 INT267114 Positive_regulation of Lmx1b 2 0.50 0.96 0.6
146 INT6831 Negative_regulation of Binding of Notch1 1 0.27 0 0.6
147 INT259764 Negative_regulation of Positive_regulation of Fbn2 1 0.03 1.7 0.6
148 INT169167 Positive_regulation of GREM1 1 0.08 1.83 0.6
149 INT194590 Localization of HOXA10 1 0.35 1.54 0.59
150 INT89126 Regulation of BMP7 7 0.45 2.5 0.58
151 INT150949 Gene_expression of Fgfr1 6 0.63 5.71 0.57
152 INT32921 Positive_regulation of Msx1 4 0.47 0.99 0.57
153 INT40367 Positive_regulation of Gene_expression of LRP5 1 0.09 0 0.57
154 INT259765 Phosphorylation of Fbn2 1 0.05 0.99 0.57
155 INT65919 Gene_expression of Ptch1 11 0.75 6.47 0.56
156 INT127648 Gene_expression of Wnt7a 2 0.13 1.11 0.56
157 INT110782 Negative_regulation of Localization of Notch1 1 0.03 0.33 0.56
158 INT84826 Negative_regulation of ACD 6 0.50 4.02 0.55
159 INT110785 Positive_regulation of Protein_catabolism of Notch1 1 0.05 0.33 0.55
160 INT79888 Gene_expression of Notch2 3 0.43 0.39 0.54
161 INT249339 Gene_expression of MBNL1 4 0.17 3.64 0.53
162 INT217394 Regulation of Binding of PSEN1 1 0.44 1.58 0.53
163 INT165537 Negative_regulation of Bmp7 2 0.43 0.55 0.52
164 INT135062 Transcription of Gli3 1 0.05 0 0.52
165 INT159214 Positive_regulation of Gene_expression of BMP7 6 0.46 2.16 0.51
166 INT163993 Gene_expression of Hnf1a 2 0.65 1.38 0.49
167 INT306741 Positive_regulation of Positive_regulation of TP63 2 0.05 1.16 0.49
168 INT146776 Transcription of Fgfr1 1 0.45 0.67 0.49
169 INT146777 Regulation of Transcription of Fgfr1 1 0.23 0.67 0.49
170 INT278121 Negative_regulation of Negative_regulation of TP63 1 0.03 0 0.48
171 INT129620 Regulation of Gene_expression of Bmp7 3 0.42 3.2 0.47
172 INT206484 Localization of Shh 2 0.75 1.14 0.46
173 INT142124 Binding of Bmp4 1 0.35 0.46 0.45
174 INT316041 Transcription of Psen2 1 0.64 1.1 0.45
175 INT232798 Positive_regulation of Gene_expression of Shh 7 0.70 1.49 0.44
176 INT267113 Regulation of Gene_expression of Lmx1b 2 0.62 1.36 0.44
177 INT234249 Regulation of PSEN1 6 0.37 2.21 0.43
178 INT188371 Regulation of Localization of Fgfr1 1 0.10 1.02 0.43
179 INT234257 Regulation of Gene_expression of PSEN1 6 0.44 1.98 0.42
180 INT247307 Negative_regulation of Msx1 3 0.22 0.11 0.42
181 INT193856 Localization of Psen1 19 0.73 9.79 0.41
182 INT180688 Transcription of Bmp4 3 0.58 0.35 0.41
183 INT180702 Positive_regulation of Transcription of Bmp4 3 0.42 0.35 0.41
184 INT155087 Positive_regulation of PBX2 1 0.15 1.19 0.41
185 INT118460 Binding of Bmp7 3 0.46 1.3 0.4
186 INT35096 Negative_regulation of Negative_regulation of Notch2 1 0.36 0 0.4
187 INT36396 Positive_regulation of Psen2 6 0.44 4.57 0.39
188 INT208559 Negative_regulation of Gene_expression of Shh 8 0.43 1.58 0.38
189 INT231199 Positive_regulation of Localization of Twist1 3 0.50 1.45 0.38
190 INT50884 Binding of MBNL1 3 0.23 0.32 0.37
191 INT177773 Localization of PSEN1 4 0.73 0.89 0.36
192 INT123421 Binding of Lmx1b 1 0.36 0.54 0.35
193 INT259761 Negative_regulation of Fbn2 2 0.03 1.1 0.34
194 INT111230 Transcription of LEF1 3 0.30 1.72 0.33
195 INT242130 Positive_regulation of Positive_regulation of Dkk1 2 0.49 1.71 0.33
196 INT261682 Positive_regulation of Positive_regulation of PSEN2 1 0.21 0.55 0.33
197 INT344976 Positive_regulation of Negative_regulation of Dkk1 1 0.49 1.13 0.33
198 INT150948 Positive_regulation of Gene_expression of Fgfr1 3 0.15 3.19 0.32
199 INT196032 Positive_regulation of Gene_expression of Bmp7 10 0.17 1.31 0.31
200 INT196024 Gene_expression of Bmp7 20 0.26 1.88 0.3
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