GO:0030332

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Name cyclin binding
Categary Function
Go Slim No
Go Link GO:0030332
Unique Molecular Interactions 179
Total Molecular Interactions 254
Total Single Events 1317
Pain Genes Associated 16

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for cyclin binding. They are ordered first by their pain relevance and then by number of times they were reported for cyclin binding. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT113844 CDKN1A Negative_regulation of CDK2 4 0.49 1.18 1.27
2 INT225158 Binding of CDK2 and CDKN1A 7 0.30 3.26 1.02
3 INT92404 PSRC1 Regulation of CDKN1A 1 0.33 0.66 0.89
4 INT139079 Tnip1 Negative_regulation of Ptch1 1 0.20 0.63 0.62
5 INT166398 CDKN1B Regulation of Gene_expression of CDKN1A 1 0.46 0.83 0.61
6 INT166399 CDKN1A Regulation of Gene_expression of CDKN1B 1 0.46 0.83 0.61
7 INT166395 CDKN1A Regulation of Gene_expression of IFI27 1 0.32 0.83 0.61
8 INT166402 CDKN1A Regulation of Gene_expression of TP53 1 0.27 0.83 0.61
9 INT166392 IFI27 Regulation of Gene_expression of CDKN1A 1 0.32 0.83 0.61
10 INT92403 PSRC1 Regulation of Positive_regulation of CDKN1A 1 0.33 0.45 0.6
11 INT164265 TGM7 Negative_regulation of CDK2 1 0.26 1.08 0.53
12 INT319554 Sgk1 Regulation of Cdkn1a 1 0.26 0.09 0.45
13 INT119262 PPM1E Negative_regulation of Positive_regulation of CDKN1A 1 0.01 0.96 0.33
14 INT172977 Cdkn1a Negative_regulation of Positive_regulation of Inca1 1 0.00 1.39 0.27
15 INT172975 Trp53 Positive_regulation of Cdkn1a 1 0.03 1.35 0.26
16 INT225160 Negative_regulation of Binding of CDK2 and CDKN1A 1 0.35 0 0.25
17 INT245555 Runx1 Negative_regulation of Cdkn1a 1 0.29 1.17 0.23
18 INT245565 Runx1 Negative_regulation of Negative_regulation of Cdkn1a 1 0.29 1.17 0.23
19 INT256629 Binding of Ptch1 and Shh 7 0.42 4.22 0.19
20 INT212084 NOXO1 Positive_regulation of CDKN1A 1 0.06 0.53 0.19
21 INT119263 Binding of CDKN1A and PPM1E 1 0.01 0.46 0.17
22 INT123192 Bmp6 Positive_regulation of CDKN1A 1 0.18 0.61 0.14
23 INT302144 CDKN2A Regulation of CDKN1A 1 0.11 0.51 0.14
24 INT88410 BMP7 Negative_regulation of CDK2 1 0.35 0 0.14
25 INT193789 SDF2L1 Positive_regulation of CDKN1A 1 0.00 0.68 0.13
26 INT193785 SDF2L1 Positive_regulation of Gene_expression of CDKN1A 1 0.00 0.68 0.13
27 INT196433 Cdk4 Negative_regulation of Ccnd1 1 0.10 1.17 0.13
28 INT345343 PTCH1 Regulation of Negative_regulation of SMO 1 0.09 2.3 0.13
29 INT262751 Binding of PTCH1 and SMO 1 0.25 1.29 0.1
30 INT306274 Binding of CCNB1 and CDK1 1 0.19 0.13 0.09
31 INT185278 Binding of CCND1 and CDK6 3 0.13 1.62 0.08
32 INT270457 Binding of Ptch1 and Gli1 1 0.02 1.3 0.08
33 INT237922 TNFSF10 Positive_regulation of CDKN1A 1 0.09 3.28 0.08
34 INT302158 CDKN1A Regulation of CDKN2A 1 0.04 0.26 0.08
35 INT320267 CCNA2 Positive_regulation of CDK1 1 0.12 1.08 0.08
36 INT88411 Positive_regulation of PDGFA Positive_regulation of CDK2 1 0.11 0 0.07
37 INT258021 Positive_regulation of Binding of CDK2 and CDKN1A 1 0.11 0.84 0.07
38 INT193783 ITIH4 Regulation of Gene_expression of CDKN1A 1 0.03 0.55 0.07
39 INT119268 CDKN1A Regulation of CREBBP 1 0.21 0.44 0.07
40 INT88408 PDGFA Positive_regulation of CDK2 1 0.11 0 0.07
41 INT119266 CDKN1A Regulation of EP300 1 0.47 0.44 0.07
42 INT302160 LAMTOR1 Regulation of CDKN1A 1 0.08 0.26 0.06
43 INT302127 MRPL28 Regulation of CDKN1A 1 0.09 0.26 0.06
44 INT302130 CDKN1A Regulation of CDKN1B 1 0.04 0.26 0.05
45 INT302176 CDKN1C Regulation of CDKN1A 1 0.09 0.26 0.05
46 INT204073 Binding of Cdkn2a and Cdk4 1 0.02 0.78 0.05
47 INT204072 Binding of Cdkn2a and Cdk6 1 0.02 0.78 0.05
48 INT302163 IFI27 Regulation of CDKN1A 1 0.11 0.26 0.05
49 INT333852 Binding of Ccna1 and Cdk2 1 0.20 0.48 0.04
50 INT176224 Binding of CDKN1A and PCNA 4 0.08 2.52 0.03
51 INT302159 TSC1 Positive_regulation of Transcription of CDKN1A 1 0.00 0.28 0.03
52 INT255756 Ptch1 Positive_regulation of Phosphorylation of Pik3r1 1 0.16 1.08 0.03
53 INT303091 Rorb Regulation of CDKN1A 1 0.00 0.52 0.03
54 INT255733 Ptch1 Positive_regulation of Pik3r1 1 0.16 1.08 0.03
55 INT283722 Id2 Negative_regulation of Transcription of CDKN1A 1 0.45 0.11 0.03
56 INT238395 BAX Regulation of CDKN1A 1 0.03 0.31 0.03
57 INT302134 TP53 Positive_regulation of Transcription of CDKN1A 1 0.04 0.28 0.03
58 INT94159 Positive_regulation of CDK1 Negative_regulation of RB1 1 0.45 0.93 0.03
59 INT94158 CDK1 Negative_regulation of RB1 1 0.41 0.92 0.03
60 INT223066 CDKN1A Negative_regulation of CCND1 1 0.04 0.66 0.03
61 INT289608 Binding of CDK2 and CCNE2 5 0.06 4.89 0
62 INT201771 CDKN1A Positive_regulation of Localization of Ccnd1 1 0.04 0 0
63 INT219412 CDK2 Regulation of PCNA 1 0.20 0.11 0
64 INT233276 Cdkn1a Regulation of Hoxa10 1 0.12 0.26 0
65 INT225228 Binding of Cdk4 and Cdkn2a 1 0.21 1.24 0
66 INT182942 VDR Positive_regulation of CDKN1A 1 0.35 0.38 0
67 INT215766 Dio1 Regulation of Cdk6 1 0.01 0.05 0
68 INT255758 Ptch1 Positive_regulation of Akt1 1 0.21 1.14 0
69 INT238402 ELANE Positive_regulation of Gene_expression of CDKN1A 1 0.03 0.48 0
70 INT272514 Cdk4 Positive_regulation of Phosphorylation of Ccnd3 1 0.01 0 0
71 INT277691 Cdkn1a Negative_regulation of Positive_regulation of Casp3 1 0.00 1.01 0
72 INT255732 Ptch1 Positive_regulation of hs 1 0.06 1.26 0
73 INT225157 CDKN1A Regulation of CHKA 1 0.12 0.58 0
74 INT268316 Cdk1 Positive_regulation of Mcm3 1 0.28 0.25 0
75 INT298197 EGFR Regulation of CDKN1A 1 0.04 1.14 0
76 INT325156 CDKN1B Negative_regulation of CDK2 1 0.49 0.11 0
77 INT205975 Binding of PTCH1 and Smo 1 0.02 0.72 0
78 INT214892 Positive_regulation of HGF Positive_regulation of CDKN1A 1 0.17 0.31 0
79 INT185281 Binding of CDK6 and CDKN2A 1 0.29 0.87 0
80 INT215706 Binding of Cdk6 and Lamtor1 1 0.04 0 0
81 INT176292 Fasl Regulation of Gene_expression of CDKN1A 1 0.34 0.84 0
82 INT225229 Binding of Cdk6 and Cdkn2a 1 0.19 1.25 0
83 INT255755 Ptch1 Regulation of Positive_regulation of Ins1 1 0.05 0.28 0
84 INT214918 Gtf3a Positive_regulation of CDKN1A 1 0.01 0.66 0
85 INT176288 Binding of Cdk2 and Pcna 1 0.01 0.66 0
86 INT205958 GLI1 Positive_regulation of Gene_expression of PTCH1 1 0.35 0.57 0
87 INT205960 Binding of PTCH1 and SHH 1 0.21 0.71 0
88 INT215700 Binding of Cdkn2b and Cdk6 1 0.02 0 0
89 INT182399 E2F2 Regulation of CDK1 1 0.00 0.09 0
90 INT215768 Dio1 Regulation of Cdk4 1 0.01 0.05 0
91 INT270461 Shh Regulation of Gene_expression of Ptch1 1 0.48 0.07 0
92 INT215690 Binding of Cdk6 and Cdkn1c 1 0.03 0 0
93 INT268318 Cdk1 Positive_regulation of Orc2 1 0.29 0.25 0
94 INT182912 Binding of CDKN1A and FRA8E 1 0.02 0.37 0
95 INT233274 Tpt1 Regulation of Cdkn1a 1 0.05 0.26 0
96 INT214890 GOPC Positive_regulation of CDKN1A 1 0.06 0.57 0
97 INT325152 CDKN1A Negative_regulation of CCNE2 1 0.07 0.1 0
98 INT255753 Ptch1 Positive_regulation of Phosphorylation of Gopc 1 0.13 1.33 0
99 INT301365 Stat1 Positive_regulation of Cdkn1a 1 0.03 0.38 0
100 INT182406 NFYA Regulation of CDK1 1 0.00 0.09 0
101 INT219426 CDK2 Regulation of HNF4A 1 0.01 0.11 0
102 INT305986 Binding of Nfe2l2 and Cul3 1 0.39 0.44 0
103 INT185280 Binding of CDK4 and CDK6 1 0.20 0.87 0
104 INT214891 HGF Positive_regulation of CDKN1A 1 0.25 1.15 0
105 INT182935 KCNIP3 Regulation of CDKN1A 1 0.45 0.96 0
106 INT204078 Binding of CDKN2A and Cdk4 1 0.15 0.72 0
107 INT215682 Binding of Cdkn1b and Cdk6 1 0.03 0 0
108 INT268319 Cdk1 Positive_regulation of Cdc20 1 0.32 0.25 0
109 INT314688 Binding of CCNE1 and CDK2 1 0.04 1.41 0
110 INT286574 Gene_expression of Pkd1 Negative_regulation of Cdk2 1 0.10 0.09 0
111 INT214919 Pkd1 Positive_regulation of CDKN1A 1 0.51 2.6 0
112 INT215701 Slc3a1 Regulation of Cdk6 1 0.01 0.05 0
113 INT260074 Binding of BRCA2 and PTCH1 1 0.40 0.15 0
114 INT256632 Binding of PTCH1 and Jkamp 1 0.00 2.32 0
115 INT301364 Stat1 Positive_regulation of Cdkn1a 1 0.03 0.39 0
116 INT219413 CDK2 Regulation of SKP2 1 0.23 0.11 0
117 INT295043 Akt1 Positive_regulation of Cdk2 1 0.10 0.93 0
118 INT268317 Cdk1 Positive_regulation of Mcm7 1 0.33 0.25 0
119 INT255744 Binding of hs and Ptch1 1 0.06 1.32 0
120 INT182957 CDKN1A Negative_regulation of HNF4A 1 0.02 0.11 0
121 INT271997 Binding of Cdk1 and Plk1 1 0.03 0.3 0
122 INT214917 Pkd1 Positive_regulation of Negative_regulation of CDKN1A 1 0.37 1.46 0
123 INT204077 Binding of CDKN2A and Cdk6 1 0.15 0.72 0
124 INT205965 Binding of Ptch1 and Smo 1 0.03 0.72 0
125 INT238401 PPARA Positive_regulation of Gene_expression of CDKN1A 1 0.11 0.48 0
126 INT270466 Ptch1 Regulation of Gene_expression of Shh 1 0.48 0.07 0
127 INT255750 Ptch1 Positive_regulation of Ins1 1 0.10 0.35 0
128 INT260073 Binding of FANCC and PTCH1 1 0.33 0.49 0
129 INT215709 Slc3a1 Regulation of Cdk4 1 0.01 0.05 0
130 INT260067 Binding of PTCH1 and XPA 1 0.26 1.08 0
131 INT205976 Binding of Ptch1 and SMOX 1 0.21 0.72 0
132 INT205962 Binding of PTCH1 and SMOX 1 0.14 0.72 0
133 INT182917 Binding of VDR and Positive_regulation of Gene_expression of CDKN1A 1 0.35 0.31 0
134 INT322544 Binding of CDK2 and Ccne1 1 0.16 0 0
135 INT338972 Binding of CDKN1A and TP53 1 0.10 0.98 0
136 INT322503 Negative_regulation of Binding of CDK2 and CCNE2 1 0.01 0.25 0
137 INT255734 Ptch1 Regulation of Ins1 1 0.09 1.46 0
138 INT333850 Binding of Ccne1 and Cdk2 1 0.26 0 0
139 INT268315 Cdk1 Positive_regulation of Mcm5 1 0.33 0.25 0
140 INT255760 Ptch1 Regulation of TNF 1 0.13 1.33 0
141 INT255741 Ptch1 Positive_regulation of Phosphorylation of Ins1 1 0.09 2.21 0
142 INT205977 Binding of SHH and Ptch1 1 0.31 0.71 0
143 INT205961 GLI1 Positive_regulation of Negative_regulation of PTCH1 1 0.25 0.58 0
144 INT215703 Binding of Kras and Cdk6 1 0.01 0 0
145 INT277694 Cdkn1a Positive_regulation of Positive_regulation of Casp3 1 0.00 1.01 0
146 INT243232 Ighmbp2 Negative_regulation of Ptch1 1 0.02 0.22 0
147 INT255749 Ptch1 Positive_regulation of Phosphorylation of Slc2a4 1 0.15 1.32 0
148 INT255735 Ptch1 Positive_regulation of Phosphorylation of Akt1 1 0.27 2.83 0
149 INT182931 VDR Positive_regulation of Gene_expression of CDKN1A 1 0.48 0.86 0
150 INT182911 KCNIP3 Positive_regulation of CDKN1A 1 0.51 0.35 0
151 INT271998 Cdk1 Positive_regulation of Phosphorylation of Tsc1 1 0.17 0.3 0
152 INT255746 Hspa1a Positive_regulation of Positive_regulation of Ptch1 1 0.19 0.99 0
153 INT297966 CDKN1A Positive_regulation of TP53 1 0.08 0.49 0
154 INT176287 Cdk2 Positive_regulation of Phosphorylation of Esr1 1 0.05 0.67 0
155 INT219419 CDK2 Regulation of E2F2 1 0.23 0.11 0
156 INT255739 Ptch1 Positive_regulation of Gene_expression of Hspa1a 1 0.18 0.75 0
157 INT176293 Fasl Positive_regulation of Gene_expression of CDKN1A 1 0.35 0.42 0
158 INT182915 Binding of CDKN1A and KCNIP3 1 0.35 0 0
159 INT255759 Ptch1 Positive_regulation of Phosphorylation of hs 1 0.06 1.34 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for cyclin binding. They are ordered first by their pain relevance and then by number of times they were reported in cyclin binding. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT28215 Gene_expression of CDKN1A 196 0.76 113.9 18.3
2 INT75502 Positive_regulation of CDKN1A 123 0.68 70.75 14.74
3 INT62269 Gene_expression of Cdkn1a 60 0.73 35.78 9.84
4 INT57162 Positive_regulation of Gene_expression of CDKN1A 64 0.68 35.3 9.69
5 INT104330 Negative_regulation of CDKN1A 57 0.58 39.93 5.88
6 INT62270 Positive_regulation of Gene_expression of Cdkn1a 30 0.47 18.73 5.69
7 INT160055 Localization of CDKN1A 15 0.78 12.56 4.83
8 INT88414 Negative_regulation of CDK2 30 0.57 18.4 3.96
9 INT82796 Regulation of CDKN1A 22 0.53 9.83 3.33
10 INT62268 Positive_regulation of Cdkn1a 33 0.67 14.12 3.26
11 INT75505 Regulation of Gene_expression of CDKN1A 24 0.60 12.24 3.07
12 INT75499 Positive_regulation of Positive_regulation of CDKN1A 12 0.60 7.28 2.84
13 INT88412 Positive_regulation of CDK2 17 0.57 8.49 1.66
14 INT104331 Negative_regulation of Gene_expression of CDKN1A 24 0.57 13.68 1.63
15 INT113151 Positive_regulation of Ptch1 7 0.64 3.8 1.41
16 INT139077 Negative_regulation of Ptch1 5 0.56 5.22 1.29
17 INT106735 Phosphorylation of CDK2 11 0.79 4.03 1.02
18 INT250699 Binding of CDK6 3 0.33 2.54 0.97
19 INT114875 Negative_regulation of Cdk4 4 0.35 4.01 0.86
20 INT135299 Binding of PTCH1 10 0.48 12.16 0.84
21 INT114877 Gene_expression of Cdk4 12 0.69 5.98 0.79
22 INT146521 Negative_regulation of Positive_regulation of CDKN1A 6 0.42 3.29 0.79
23 INT114880 Negative_regulation of Cdk2 7 0.35 3.89 0.77
24 INT258791 Positive_regulation of CDK1 14 0.45 5.73 0.74
25 INT142416 Binding of Ptch1 6 0.34 4.92 0.74
26 INT114876 Negative_regulation of Gene_expression of Cdk4 3 0.38 2.3 0.7
27 INT62273 Gene_expression of CDK1 19 0.75 8.43 0.68
28 INT105330 Gene_expression of CDK2 31 0.63 13.7 0.67
29 INT153257 Regulation of Ptch1 6 0.36 5.92 0.67
30 INT126732 Regulation of Cdkn1a 6 0.39 2.13 0.63
31 INT114879 Gene_expression of Cdk2 5 0.55 2.33 0.6
32 INT114872 Negative_regulation of Gene_expression of Cdk2 2 0.35 1.21 0.6
33 INT113846 Negative_regulation of Positive_regulation of CDK2 1 0.48 0.39 0.6
34 INT65919 Gene_expression of Ptch1 11 0.75 6.47 0.56
35 INT163285 Negative_regulation of Phosphorylation of CDK2 2 0.32 0.52 0.48
36 INT62272 Negative_regulation of CDK1 9 0.57 6.46 0.46
37 INT97606 Negative_regulation of Cdkn1a 7 0.43 4.24 0.42
38 INT125592 Negative_regulation of Negative_regulation of CDKN1A 2 0.42 2.07 0.41
39 INT117440 Positive_regulation of Cdkn1a 3 0.67 2.95 0.4
40 INT131018 Phosphorylation of Cdkn1a 3 0.61 2.06 0.4
41 INT127451 Positive_regulation of Cdk1 1 0.20 0.27 0.4
42 INT271922 Phosphorylation of Cdk1 2 0.44 0.37 0.39
43 INT82797 Transcription of CDKN1A 11 0.69 8.01 0.32
44 INT131017 Positive_regulation of Positive_regulation of Cdkn1a 5 0.67 1.89 0.32
45 INT119269 Binding of CDKN1A 14 0.47 8.82 0.31
46 INT123529 Phosphorylation of CDKN1A 8 0.80 5.69 0.29
47 INT183055 Gene_expression of PTCH1 10 0.77 15.54 0.26
48 INT225177 Regulation of Negative_regulation of CDKN1A 1 0.39 0.26 0.25
49 INT201638 Positive_regulation of Cdk4 5 0.58 3.38 0.24
50 INT106733 Regulation of CDK2 6 0.44 4.76 0.23
51 INT94166 Phosphorylation of CDK1 10 0.79 4.75 0.2
52 INT226422 Negative_regulation of Cdk6 3 0.12 1.83 0.19
53 INT163284 Negative_regulation of Gene_expression of CDK2 5 0.32 1.6 0.16
54 INT176246 Regulation of Cdk2 6 0.30 3.31 0.15
55 INT173184 Regulation of CDK1 4 0.30 2.97 0.15
56 INT201656 Positive_regulation of Positive_regulation of Cdk4 2 0.06 2.34 0.15
57 INT196421 Negative_regulation of Cdk1 2 0.24 1.17 0.15
58 INT245263 Negative_regulation of Gene_expression of Cdkn1a 5 0.25 1.84 0.14
59 INT62271 Negative_regulation of Gene_expression of CDK1 2 0.42 1.32 0.14
60 INT123181 Positive_regulation of Negative_regulation of CDKN1A 1 0.49 0.6 0.14
61 INT61789 Negative_regulation of Cdkn1a 2 0.41 1.35 0.13
62 INT201462 Binding of CDK2 12 0.39 5.2 0.12
63 INT204063 Gene_expression of Cdk4 3 0.21 0.9 0.12
64 INT148991 Gene_expression of Cdkn1a 1 0.44 0.46 0.11
65 INT170849 Binding of Cdk4 3 0.16 2.44 0.1
66 INT167436 Localization of CDK1 2 0.14 0.41 0.1
67 INT260083 Regulation of PTCH1 11 0.27 4.46 0.09
68 INT201460 Positive_regulation of Gene_expression of CDK2 5 0.52 2.8 0.09
69 INT169428 Regulation of Gene_expression of CDK2 4 0.46 1.03 0.09
70 INT186055 Binding of CDK1 3 0.35 1.43 0.09
71 INT301361 Phosphorylation of Cdkn1a 2 0.79 1.21 0.09
72 INT106732 Regulation of Phosphorylation of CDK2 2 0.44 0.8 0.09
73 INT302272 Localization of CDK2 2 0.30 1.09 0.09
74 INT346497 Negative_regulation of Phosphorylation of Cdkn1a 1 0.41 0.83 0.09
75 INT270454 Regulation of Transcription of Ptch1 1 0.25 0.55 0.09
76 INT270450 Transcription of Ptch1 1 0.49 0.55 0.09
77 INT165148 Regulation of Binding of Ptch1 1 0.22 0.08 0.08
78 INT326819 Negative_regulation of Cdk1 1 0.16 0.39 0.08
79 INT270452 Regulation of Gene_expression of Ptch1 1 0.25 0.25 0.08
80 INT328542 Regulation of Positive_regulation of Cdkn1a 1 0.03 0.79 0.07
81 INT165154 Negative_regulation of Positive_regulation of Ptch1 1 0.34 0.09 0.07
82 INT183056 Positive_regulation of Transcription of PTCH1 1 0.28 0.46 0.07
83 INT176262 Positive_regulation of Phosphorylation of CDKN1A 3 0.49 2.12 0.06
84 INT271084 Negative_regulation of Gene_expression of Cdk6 1 0.11 1.1 0.06
85 INT255719 Phosphorylation of Ptch1 1 0.32 3.7 0.06
86 INT271086 Gene_expression of Cdk6 1 0.14 1.09 0.06
87 INT255726 Localization of Ptch1 1 0.33 1.74 0.05
88 INT176238 Gene_expression of Cdk1 5 0.46 0.94 0.04
89 INT183070 Transcription of PTCH1 2 0.68 0.95 0.04
90 INT316430 Positive_regulation of Negative_regulation of Cdkn1a 1 0.19 1.24 0.04
91 INT282568 Positive_regulation of Cdk2 6 0.34 2.95 0.03
92 INT94160 Positive_regulation of Phosphorylation of CDK1 2 0.49 0.93 0.03
93 INT309477 Positive_regulation of Cdk1 2 0.35 0.21 0.03
94 INT201468 Negative_regulation of Binding of CDK2 2 0.17 1.1 0.03
95 INT224295 Protein_catabolism of CDKN1A 1 0.12 0.55 0.03
96 INT94161 Negative_regulation of Phosphorylation of CDK1 1 0.41 0.93 0.03
97 INT183064 Regulation of Gene_expression of PTCH1 1 0.34 0.22 0.03
98 INT172965 Negative_regulation of Positive_regulation of Cdkn1a 4 0.41 1.84 0
99 INT204060 Gene_expression of Cdk6 3 0.26 0.83 0
100 INT236713 Regulation of Cdk4 3 0.22 1.35 0
101 INT236692 Phosphorylation of Cdk4 2 0.35 0.82 0
102 INT205968 Negative_regulation of PTCH1 2 0.58 2.35 0
103 INT169427 Transcription of CDK2 2 0.09 0.42 0
104 INT325167 Gene_expression of CDK6 2 0.43 0 0
105 INT255723 Positive_regulation of Gene_expression of Ptch1 2 0.39 1.3 0
106 INT245623 Negative_regulation of Cdk4 2 0.18 1.24 0
107 INT242456 Binding of Cdk2 2 0.16 1.29 0
108 INT271100 Regulation of Positive_regulation of CDKN1A 2 0.44 1.52 0
109 INT236691 Regulation of Cdk1 2 0.20 0.46 0
110 INT295036 Positive_regulation of Positive_regulation of Cdk2 2 0.34 0.93 0
111 INT256631 Positive_regulation of PTCH1 2 0.13 1.97 0
112 INT236705 Phosphorylation of Cdk2 2 0.31 1.39 0
113 INT233247 Transcription of Cdkn1a 1 0.39 0.26 0
114 INT247423 Phosphorylation of Cdk4 1 0.32 1.14 0
115 INT277672 Localization of Cdkn1a 1 0.07 0.95 0
116 INT285901 Regulation of Transcription of CDK2 1 0.03 0.7 0
117 INT289866 Protein_catabolism of CDK1 1 0.46 0 0
118 INT247426 Negative_regulation of Phosphorylation of Cdk4 1 0.17 1.15 0
119 INT260088 Negative_regulation of Transcription of PTCH1 1 0.43 0.4 0
120 INT295035 Negative_regulation of Positive_regulation of Cdk2 1 0.22 0.87 0
121 INT169913 Positive_regulation of Gene_expression of Cdk2 1 0.21 0.08 0
122 INT277859 Protein_catabolism of Cdk2 1 0.43 0.23 0
123 INT289863 Negative_regulation of Positive_regulation of CDK1 1 0.31 0 0
124 INT333793 Transcription of Cdk2 1 0.46 0 0
125 INT341855 Positive_regulation of Positive_regulation of CDK2 1 0.06 0.51 0
126 INT301362 Negative_regulation of Positive_regulation of Cdkn1a 1 0.41 0.39 0
127 INT201654 Localization of Cdk4 1 0.08 0 0
128 INT289862 Positive_regulation of Gene_expression of CDK1 1 0.26 0 0
129 INT260089 Localization of PTCH1 1 0.70 0.37 0
130 INT333816 Regulation of Positive_regulation of Cdk2 1 0.30 0 0
131 INT289620 Regulation of Binding of CDK2 1 0.28 0.22 0
132 INT204062 Negative_regulation of Gene_expression of Cdk4 1 0.12 0.47 0
133 INT289869 Positive_regulation of Protein_catabolism of CDK1 1 0.26 0 0
134 INT333821 Regulation of Cdk6 1 0.23 0 0
135 INT256564 Regulation of Gene_expression of Cdk4 1 0.40 0.73 0
136 INT282083 Regulation of Gene_expression of Cdkn1a 1 0.15 1.25 0
137 INT270455 Negative_regulation of Gene_expression of Ptch1 1 0.39 0.66 0
138 INT204061 Negative_regulation of Gene_expression of Cdk6 1 0.12 0.47 0
139 INT269894 Positive_regulation of Gene_expression of Cdk4 1 0.17 0 0
140 INT234750 Regulation of Regulation of CDKN1A 1 0.09 0.45 0
141 INT268284 Gene_expression of Cdk1 1 0.26 0.25 0
142 INT302260 Negative_regulation of CDK6 1 0.19 0.29 0
143 INT215740 Regulation of Gene_expression of Cdk4 1 0.14 0 0
144 INT325169 Regulation of Negative_regulation of CDK2 1 0.34 0.05 0
145 INT245621 Negative_regulation of Negative_regulation of Cdk4 1 0.18 0.09 0
146 INT333817 Localization of Cdk2 1 0.50 0.22 0
147 INT225184 Positive_regulation of Binding of CDKN1A 1 0.43 0.87 0
148 INT215749 Regulation of Gene_expression of Cdk6 1 0.17 0 0
149 INT225187 Positive_regulation of Binding of CDK2 1 0.56 0.87 0
150 INT325171 Regulation of Gene_expression of CDK6 1 0.25 0 0
151 INT245626 Regulation of Cdk4 1 0.19 0.09 0
152 INT277673 Positive_regulation of Localization of Cdkn1a 1 0.05 1.01 0
153 INT282089 Binding of Cdkn1a 1 0.12 0.36 0
154 INT236709 Phosphorylation of Cdk6 1 0.34 0.82 0
155 INT183052 Positive_regulation of Gene_expression of PTCH1 1 0.38 0.26 0
156 INT260080 Negative_regulation of Gene_expression of PTCH1 1 0.58 2.09 0
157 INT250716 Positive_regulation of Transcription of CDKN1A 1 0.18 0.48 0
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