GO:0030343

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Name vitamin D3 25-hydroxylase activity
Categary Function
Go Slim No
Go Link GO:0030343
Unique Molecular Interactions 75
Total Molecular Interactions 96
Total Single Events 990
Pain Genes Associated 3

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for vitamin D3 25-hydroxylase activity. They are ordered first by their pain relevance and then by number of times they were reported for vitamin D3 25-hydroxylase activity. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT100784 RYBP Positive_regulation of CYP3A4 1 0.44 0 1.54
2 INT123899 Binding of CYP3A4 and UGT2B7 1 0.52 0 1.46
3 INT264988 Binding of CYP2C19 and CYP3A4 1 0.18 0.72 1.09
4 INT264987 Binding of CYP2C9 and CYP3A4 1 0.19 0.71 1.08
5 INT100783 Binding of CYP2B6 and CYP3A4 2 0.17 2 0.77
6 INT186674 Binding of BGLAP and CYP27A1 1 0.01 1.91 0.71
7 INT315334 Binding of CYP3A4 and CDIPT 3 0.04 0.85 0.59
8 INT123897 Binding of CYP3A4 and SLC35A2 1 0.39 0 0.45
9 INT123898 CYP3A4 Regulation of UGT2B7 1 0.22 0 0.41
10 INT320810 Protein_catabolism of COL1A2 Positive_regulation of Localization of CYP27A1 1 0.04 1.05 0.4
11 INT207355 ZNF398 Regulation of CYP27A1 1 0.00 0 0.31
12 INT132984 CYP3A4 Positive_regulation of Gene_expression of PPP4C 1 0.44 0 0.3
13 INT262227 Nr1h4 Regulation of Transcription of CYP3A4 1 0.08 0.12 0.26
14 INT272997 Binding of CYP3A4 and IL33 1 0.03 0 0.25
15 INT262229 Binding of CYP3A4 and Casr 1 0.03 0.37 0.24
16 INT115729 Binding of CYP3A7 and CYP3A4 1 0.44 0.05 0.23
17 INT318039 CDIPT Positive_regulation of CYP3A4 1 0.06 0.06 0.2
18 INT262224 Sfn Negative_regulation of Transcription of CYP3A4 1 0.06 0.58 0.2
19 INT330986 CYP2C9 Positive_regulation of Gene_expression of CYP3A4 1 0.39 0 0.18
20 INT151895 Binding of CYP3A4 and GBE1 1 0.01 0.24 0.18
21 INT180560 Binding of COMP and CYP27A1 1 0.12 0.47 0.18
22 INT207339 TBXA2R Negative_regulation of Negative_regulation of CYP27A1 1 0.01 0 0.17
23 INT207354 TBXA2R Regulation of Gene_expression of CYP27A1 1 0.01 0 0.17
24 INT207342 PTGDS Negative_regulation of Gene_expression of CYP27A1 1 0.02 0 0.17
25 INT207351 ZNF398 Negative_regulation of CYP27A1 1 0.00 0 0.17
26 INT207340 PTGER2 Negative_regulation of Gene_expression of CYP27A1 1 0.00 0 0.17
27 INT207357 TBXA2R Positive_regulation of CYP27A1 1 0.01 0 0.16
28 INT207349 TBXA2R Regulation of CYP27A1 1 0.01 0 0.16
29 INT85828 CYP3A4 Negative_regulation of CYP2D6 1 0.47 0.06 0.16
30 INT180562 Binding of CYP27A1 and HEYL 1 0.02 0.29 0.16
31 INT151894 NR1I2 Positive_regulation of CYP3A4 1 0.19 0.23 0.16
32 INT273561 Binding of CYP1A1 and CYP3A4 1 0.02 0.12 0.15
33 INT262231 Sfn Negative_regulation of Gene_expression of CYP3A4 1 0.06 0.26 0.14
34 INT207335 PTGDS Negative_regulation of Negative_regulation of CYP27A1 1 0.02 0 0.14
35 INT262232 Nr1i2 Positive_regulation of Gene_expression of CYP3A4 1 0.17 0.26 0.14
36 INT207346 PTGER2 Negative_regulation of Negative_regulation of CYP27A1 1 0.00 0 0.14
37 INT343027 Binding of CYP3A4 and Azi1 1 0.02 0.75 0.14
38 INT262228 Nr1i2 Positive_regulation of Transcription of CYP3A4 1 0.17 0.27 0.13
39 INT262226 Positive_regulation of Nr1i2 Positive_regulation of CYP3A4 1 0.17 0.68 0.12
40 INT97081 CYP3A4 Regulation of HAGH 1 0.02 0 0.11
41 INT155221 Binding of CYP3A4 and PNPLA4 1 0.09 0 0.1
42 INT264085 CYP2C19 Regulation of CYP3A4 1 0.02 0 0.09
43 INT177296 Binding of CXADR and CYP3A4 1 0.30 0 0.09
44 INT264102 Cyp1a2 Regulation of CYP3A4 1 0.03 0 0.09
45 INT264105 Cyp2e1 Regulation of CYP3A4 1 0.02 0 0.09
46 INT99476 Binding of CYP3A4 and ABCB1 2 0.28 0 0.08
47 INT177265 Binding of CYP3A4 and NR1H4 1 0.03 0 0.08
48 INT262161 Nr1i2 Positive_regulation of Gene_expression of Cyp27a1 1 0.29 0.24 0.07
49 INT264300 CTSK Positive_regulation of CYP27A1 1 0.03 0.69 0.07
50 INT339695 Binding of CYP3A4 and TRO 1 0.06 0.57 0.05
51 INT319578 CYP3A4 Regulation of ALPPL2 1 0.00 0.56 0.05
52 INT177274 Binding of CYP3A4 and TNFRSF25 1 0.19 0 0.04
53 INT177273 Binding of CYP3A4 and FAUP1 1 0.02 0 0.04
54 INT339707 TRO Positive_regulation of CYP3A4 1 0.12 0.97 0.04
55 INT199406 Binding of CYP3A4 and PPIB 1 0.40 0 0.04
56 INT207362 Negative_regulation of CPOX Negative_regulation of Gene_expression of CYP27A1 1 0.01 0 0.03
57 INT207356 PTGER2 Regulation of Gene_expression of CYP27A1 1 0.00 0.05 0.03
58 INT207361 PTGDS Regulation of Gene_expression of CYP27A1 1 0.01 0.05 0.03
59 INT199527 Ceacam1 Negative_regulation of CYP27A1 1 0.02 0.06 0.03
60 INT294894 CYP3A4 Negative_regulation of CYP2C19 1 0.08 0.13 0
61 INT96893 Binding of CYP3A4 and Orm2 1 0.07 0 0
62 INT262225 Binding of CYP3A4 and Nr1i2 1 0.13 0 0
63 INT96894 Binding of CYP3A4 and Orm1 1 0.00 0 0
64 INT135130 Binding of CYP3A4 and NR1I2 1 0.34 0.31 0
65 INT294895 CYP3A4 Negative_regulation of CYP2C9 1 0.09 0.13 0
66 INT177290 GOPC Positive_regulation of CYP3A4 1 0.15 0 0
67 INT339700 CYP2B6 Positive_regulation of CYP3A4 1 0.13 0.3 0
68 INT96892 Negative_regulation of Binding of CYP3A4 and Orm2 1 0.08 0 0
69 INT199719 2610029G23Rik Regulation of CYP3A4 1 0.01 0.45 0
70 INT180568 Binding of CYP27A1 and DMD 1 0.02 0 0
71 INT262223 Negative_regulation of Nr1i2 Negative_regulation of Gene_expression of CYP3A4 1 0.21 0.48 0
72 INT96895 Negative_regulation of Binding of CYP3A4 and Orm1 1 0.00 0 0
73 INT207363 Negative_regulation of CPOX Negative_regulation of CYP27A1 1 0.01 0 0
74 INT207336 Gene_expression of GLI2 Negative_regulation of Gene_expression of CYP27A1 1 0.00 0 0
75 INT135129 NR1I2 Regulation of Transcription of CYP3A4 1 0.58 0.6 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for vitamin D3 25-hydroxylase activity. They are ordered first by their pain relevance and then by number of times they were reported in vitamin D3 25-hydroxylase activity. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT50405 Negative_regulation of CYP3A4 238 0.59 53.65 51.51
2 INT22211 Positive_regulation of CYP3A4 110 0.70 22 28.27
3 INT12129 Gene_expression of CYP3A4 107 0.78 23.11 27.6
4 INT50579 Binding of CYP3A4 84 0.48 17.52 17.45
5 INT19132 Gene_expression of CYP27A1 83 0.75 34.31 10.17
6 INT173808 Positive_regulation of CYP27A1 35 0.68 23.7 7.87
7 INT63057 Regulation of CYP3A4 31 0.61 5.75 6.92
8 INT53184 Negative_regulation of CYP27A1 46 0.57 16.04 5.28
9 INT114718 Positive_regulation of Gene_expression of CYP3A4 17 0.49 4.69 4.69
10 INT158593 Negative_regulation of Negative_regulation of CYP3A4 5 0.43 1.16 4.01
11 INT134694 Binding of CYP27A1 10 0.47 5.61 3.56
12 INT180591 Protein_catabolism of CYP27A1 18 0.56 8.46 3.44
13 INT100785 Protein_catabolism of CYP3A4 7 1.00 0.76 3.01
14 INT155216 Negative_regulation of Gene_expression of CYP3A4 9 0.56 3.81 2.71
15 INT207366 Negative_regulation of Gene_expression of CYP27A1 11 0.44 4.82 2.67
16 INT122709 Localization of CYP3A4 16 0.75 5.41 2.38
17 INT143395 Regulation of CYP27A1 25 0.53 9.01 2.18
18 INT19131 Localization of CYP27A1 14 0.80 8.19 2.15
19 INT117898 Positive_regulation of Protein_catabolism of CYP3A4 1 0.67 0 2.08
20 INT149263 Regulation of Negative_regulation of CYP3A4 4 0.44 1 2.03
21 INT180581 Negative_regulation of Protein_catabolism of CYP27A1 2 0.29 3.19 1.43
22 INT117897 Negative_regulation of Protein_catabolism of CYP3A4 1 0.55 0 1.28
23 INT125541 Transcription of CYP3A4 7 0.69 2.14 1.02
24 INT269764 Positive_regulation of Localization of CYP27A1 4 0.38 2.45 0.8
25 INT257885 Negative_regulation of Positive_regulation of CYP27A1 2 0.37 1.62 0.57
26 INT199410 Negative_regulation of Binding of CYP3A4 4 0.43 0.96 0.5
27 INT135131 Regulation of Gene_expression of CYP3A4 8 0.59 4.32 0.44
28 INT199409 Positive_regulation of Negative_regulation of CYP3A4 7 0.50 2.54 0.41
29 INT173810 Positive_regulation of Gene_expression of CYP27A1 5 0.49 1.35 0.4
30 INT63317 Positive_regulation of Negative_regulation of CYP27A1 2 0.45 1.41 0.37
31 INT155222 Positive_regulation of Transcription of CYP3A4 2 0.50 0.13 0.34
32 INT296900 Negative_regulation of Binding of CYP27A1 1 0.17 0.83 0.33
33 INT262096 Gene_expression of Cyp27a1 1 0.30 1.21 0.32
34 INT158581 Negative_regulation of Positive_regulation of CYP3A4 7 0.43 1.83 0.29
35 INT270115 Negative_regulation of Localization of CYP27A1 2 0.02 1.11 0.26
36 INT63318 Regulation of Negative_regulation of CYP27A1 1 0.44 0.9 0.18
37 INT207368 Positive_regulation of Positive_regulation of CYP27A1 1 0.04 0.37 0.17
38 INT345946 Negative_regulation of Localization of CYP3A4 1 0.09 0.56 0.16
39 INT180585 Positive_regulation of Protein_catabolism of CYP27A1 1 0.23 0.39 0.14
40 INT100094 Regulation of Positive_regulation of CYP3A4 3 0.45 0.31 0.1
41 INT262048 Positive_regulation of Gene_expression of Cyp27a1 1 0.18 0.68 0.08
42 INT262099 Negative_regulation of Gene_expression of Cyp27a1 1 0.17 0.68 0.08
43 INT262138 Positive_regulation of Regulation of CYP3A4 1 0.15 0.06 0.07
44 INT173811 Regulation of Gene_expression of CYP27A1 3 0.44 0.78 0
45 INT123100 Positive_regulation of Positive_regulation of CYP3A4 2 0.54 0 0
46 INT277007 Negative_regulation of Transcription of CYP3A4 1 0.39 0.34 0
47 INT277008 Regulation of Transcription of CYP3A4 1 0.41 0.67 0
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