GO:0030414

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Name peptidase inhibitor activity
Categary Function
Go Slim No
Go Link GO:0030414
Unique Molecular Interactions 605
Total Molecular Interactions 781
Total Single Events 8335
Pain Genes Associated 55

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for peptidase inhibitor activity. They are ordered first by their pain relevance and then by number of times they were reported for peptidase inhibitor activity. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT227157 Binding of PEBP1 and Gpm6a 1 0.00 1.28 5.52
2 INT143946 Binding of Pebp1 and Mastl 1 0.00 2.04 3.82
3 INT166947 Ngf Positive_regulation of KNG1 1 0.00 0.47 1.86
4 INT169468 Binding of Egfr and Spink3 1 0.37 3.73 1.83
5 INT94617 KNG1 Positive_regulation of Localization of Calca 1 0.00 0.75 1.7
6 INT94618 KNG1 Positive_regulation of Calca 1 0.00 0.75 1.66
7 INT191618 Binding of App and Nf1 1 0.35 3.77 1.65
8 INT24689 Binding of PLAT and Serpine1 1 0.00 3.77 1.64
9 INT266406 Binding of APP and Ager 1 0.00 2.34 1.57
10 INT8734 Pebp1 Positive_regulation of Oprd1 1 0.01 0 1.54
11 INT66713 Binding of BDKRB1 and KNG1 2 0.22 0.39 1.53
12 INT61443 Binding of KNG1 and Tyr 1 0.00 0 1.46
13 INT223156 Il6 Regulation of A2m 1 0.11 2.79 1.39
14 INT56093 FGFR1 Regulation of Gene_expression of SERPINE1 1 0.23 1.71 1.37
15 INT126639 KNG1 Positive_regulation of Alox15 1 0.17 0.62 1.36
16 INT126640 Negative_regulation of KNG1 Positive_regulation of Alox15 1 0.14 0.62 1.36
17 INT56087 TNF Regulation of Gene_expression of SERPINE1 1 0.43 1.67 1.33
18 INT121457 KNG1 Positive_regulation of Trpv1 1 0.16 0.91 1.33
19 INT343949 SERPINE2 Positive_regulation of Positive_regulation of Slco1c1 1 0.00 0.59 1.27
20 INT46022 tp Positive_regulation of SERPINB1 1 0.04 0 1.26
21 INT120205 Binding of App and Ern1 1 0.05 2.55 1.18
22 INT123260 Binding of Gabrg2 and Serpini1 1 0.02 0.63 1.16
23 INT123261 Gabrg2 Regulation of Serpini1 1 0.01 0.63 1.16
24 INT25109 Negative_regulation of COL7A1 Positive_regulation of PLEKHM1 1 0.01 0 1.16
25 INT25114 COL7A1 Positive_regulation of PLEKHM1 1 0.01 0 1.15
26 INT224728 Col7a1 Positive_regulation of Cia1 1 0.00 2.9 1.12
27 INT168529 APP Regulation of FSIP1 2 0.65 2.26 1.07
28 INT343950 SERPINE2 Positive_regulation of Slco1c1 1 0.00 1.63 1.07
29 INT63543 Binding of Adra2a and Serpini1 1 0.13 0 1
30 INT73681 Regulation of KNG1 Positive_regulation of ALB 1 0.30 0.38 0.99
31 INT73680 KNG1 Positive_regulation of ALB 1 0.51 0.38 0.98
32 INT66712 Binding of BDKRB2 and KNG1 1 0.06 0.22 0.97
33 INT66711 Negative_regulation of Binding of BDKRB2 and KNG1 1 0.07 0.22 0.97
34 INT303690 KNG1 Positive_regulation of CPOX 1 0.01 0.76 0.96
35 INT66714 Negative_regulation of Binding of BDKRB1 and KNG1 1 0.13 0.22 0.96
36 INT42482 Binding of Cpe and Pebp1 1 0.02 0 0.95
37 INT159996 Prkcg Regulation of Gene_expression of App 1 0.42 0.32 0.92
38 INT159993 App Regulation of Gene_expression of Bace1 1 0.46 0.32 0.92
39 INT159994 App Regulation of Gene_expression of Prkcg 1 0.42 0.32 0.92
40 INT169477 TGFB3 Positive_regulation of Spink3 1 0.02 1.83 0.89
41 INT84369 Ngf Positive_regulation of KNG1 1 0.04 0.29 0.89
42 INT96008 Binding of KNG1 and EBP 1 0.01 0.15 0.88
43 INT96010 KNG1 Positive_regulation of Binding of MTG1 1 0.32 0.15 0.88
44 INT96009 KNG1 Positive_regulation of MTG1 1 0.32 0.15 0.88
45 INT124427 NPEPPS Positive_regulation of Protein_catabolism of COL7A1 1 0.00 0.56 0.84
46 INT167431 Binding of APP and MYO1C 1 0.23 1.38 0.83
47 INT225690 KNG1 Positive_regulation of TRPV1 1 0.42 0.7 0.83
48 INT193322 KNG1 Positive_regulation of Prh1 1 0.00 0.51 0.83
49 INT107917 RETNLB Positive_regulation of Gene_expression of App 1 0.01 1.2 0.79
50 INT150636 Binding of KNG1 and CD177 1 0.10 0.37 0.79
51 INT328976 Binding of Cst7 and Cts 1 0.08 0.92 0.79
52 INT16488 Binding of Serpinf2 and Crp 1 0.00 0.78 0.78
53 INT16491 Binding of ADRA1D and Serpinf2 1 0.02 0.78 0.78
54 INT16494 Binding of LPA and Serpinf2 1 0.00 0.78 0.78
55 INT16492 Positive_regulation of Binding of LPA and Serpinf2 1 0.00 0.78 0.78
56 INT16493 Positive_regulation of Binding of ADRA1D and Serpinf2 1 0.02 0.78 0.78
57 INT16489 Positive_regulation of Binding of Serpinf2 and Crp 1 0.00 0.78 0.78
58 INT129415 KNG1 Positive_regulation of Trpv1 1 0.05 0.39 0.76
59 INT107028 KNG1 Regulation of Des 1 0.01 1.7 0.76
60 INT332699 Binding of KNG1 and TRGC1 1 0.16 3.37 0.75
61 INT162241 Binding of COL7A1 and MMP13 2 0.03 0.86 0.73
62 INT328980 Binding of Cst7 and Igfals 1 0.06 0.85 0.73
63 INT162240 Binding of COL7A1 and MMP1 1 0.03 0.86 0.73
64 INT328983 Binding of Cst7 and Muted 1 0.04 0.84 0.73
65 INT162239 Binding of COL7A1 and MMP8 1 0.04 0.86 0.73
66 INT328977 Binding of Cst7 and Mup1 1 0.18 0.84 0.73
67 INT117639 Serpini1 Negative_regulation of Cpox 1 0.00 0.64 0.72
68 INT99818 IFNG Positive_regulation of Gene_expression of APP 1 0.04 0.82 0.7
69 INT121458 KNG1 Positive_regulation of Localization of Trpv1 1 0.16 0.43 0.69
70 INT126779 Binding of Serpinc1 and F8 1 0.00 1.52 0.69
71 INT303691 KNG1 Positive_regulation of AHR 1 0.03 0.98 0.69
72 INT126781 Binding of F10 and Serpinc1 1 0.00 1.51 0.69
73 INT303689 Regulation of KNG1 Positive_regulation of AHR 1 0.03 0.99 0.69
74 INT48032 Binding of Avp and Pebp1 1 0.00 0 0.68
75 INT48031 Binding of Oxt and Pebp1 1 0.01 0 0.68
76 INT169217 Binding of Pebp1 and Coc 1 0.00 0.22 0.67
77 INT329589 Serpina5 Positive_regulation of PTX3 1 0.03 1.52 0.66
78 INT95546 KNG1 Positive_regulation of Ptgir 1 0.02 0.93 0.64
79 INT96472 KNG1 Positive_regulation of Gene_expression of TRPV1 1 0.01 0.22 0.64
80 INT65256 Pebp1 Regulation of Gene_expression of Basp1 1 0.00 0.05 0.64
81 INT333165 Binding of asa and Col7a1 1 0.03 0.94 0.63
82 INT2700 Binding of App and Cpe 1 0.00 0 0.63
83 INT34005 YY1 Regulation of KNG1 1 0.04 0.38 0.63
84 INT333544 CTSB Regulation of Protein_catabolism of APP 1 0.01 0.53 0.62
85 INT121460 KNG1 Positive_regulation of Bdkrb2 1 0.08 0.44 0.62
86 INT118083 Aip Negative_regulation of Phosphorylation of APP 1 0.00 0.75 0.62
87 INT121459 Bdkrb2 Positive_regulation of KNG1 1 0.09 0.44 0.62
88 INT333543 CTSB Regulation of APP 1 0.01 0.53 0.62
89 INT337323 KNG1 Positive_regulation of PRKCA 1 0.15 0.17 0.62
90 INT84771 Positive_regulation of Binding of App and Pag1 1 0.17 0.9 0.62
91 INT267625 Binding of KNG1 and Klk1 2 0.21 2.23 0.61
92 INT284089 Binding of NTRK2 and SERPINE1 1 0.27 0.73 0.61
93 INT34840 Binding of KNG1 and PDYN 1 0.01 0 0.61
94 INT120203 Binding of App and Il1 1 0.17 1.28 0.59
95 INT142993 Serpinc1 Positive_regulation of Phosphorylation of RHOA 1 0.05 0.05 0.59
96 INT120204 Binding of App and Il1f5 1 0.09 1.28 0.59
97 INT142990 Serpinc1 Positive_regulation of Phosphorylation of S1pr1 1 0.03 0.05 0.59
98 INT87294 SERPINA3 Negative_regulation of PTGS2 1 0.25 0.6 0.58
99 INT181619 ACE Positive_regulation of KNG1 1 0.33 0.97 0.58
100 INT120347 Binding of KNG1 and MYC 1 0.21 0.17 0.58
101 INT56088 TGFB1 Positive_regulation of Transcription of SERPINE1 1 0.46 0.83 0.57
102 INT84770 Binding of App and Pag1 1 0.13 0.89 0.57
103 INT75490 LEPRE1 Positive_regulation of Gene_expression of COL7A1 1 0.03 0.52 0.57
104 INT167618 Rho Regulation of App 1 0.17 0.88 0.55
105 INT129640 Binding of Ambp and Oprd1 1 0.22 0.19 0.55
106 INT167620 Rock2 Regulation of App 1 0.13 0.87 0.55
107 INT126641 Binding of KNG1 and Bdkrb2 1 0.11 0.42 0.55
108 INT129639 Regulation of Binding of Ambp and Oprd1 1 0.17 0.19 0.55
109 INT99736 Binding of PLG and Serpinf2 1 0.01 0.73 0.55
110 INT118082 APP Positive_regulation of Casp3 1 0.00 0.5 0.54
111 INT204494 Binding of App and Fmr1 1 0.54 4.39 0.54
112 INT227908 Binding of COL7A1 and MMRN1 1 0.00 1.11 0.53
113 INT303721 KNG1 Positive_regulation of Bdkrb1 1 0.05 0.75 0.52
114 INT172248 Binding of KNG1 and NCOR2 1 0.02 0.19 0.52
115 INT303722 KNG1 Positive_regulation of Bdkrb2 1 0.01 0.7 0.52
116 INT33415 KNG1 Positive_regulation of GBP1 1 0.02 0.43 0.51
117 INT63512 Vip Positive_regulation of Localization of SERPINE2 1 0.63 1.84 0.5
118 INT322048 Prkdc Negative_regulation of Col7a1 1 0.00 0.45 0.5
119 INT224729 Negative_regulation of Col7a1 Positive_regulation of Cia1 1 0.00 1.02 0.48
120 INT58663 Binding of KNG1 and Ugt1a2 1 0.02 0.4 0.47
121 INT145260 Binding of CLU and App 1 0.00 0.74 0.46
122 INT22674 Binding of SERPINE1 and PLAT 7 0.04 0.65 0.45
123 INT327090 Negative_regulation of F12 Negative_regulation of Gene_expression of KNG1 1 0.00 0.51 0.45
124 INT96245 Negative_regulation of Tnf Positive_regulation of KNG1 1 0.01 0.59 0.45
125 INT159538 SERPINB1 Regulation of Gene_expression of CALCA 1 0.01 0.8 0.45
126 INT96246 Tnf Positive_regulation of KNG1 1 0.01 0.59 0.45
127 INT167621 Psenen Positive_regulation of App 1 0.02 0.86 0.44
128 INT167617 Bace2 Positive_regulation of App 1 0.06 0.87 0.44
129 INT48715 PTGER2 Regulation of Gene_expression of SERPINE1 1 0.21 0.6 0.44
130 INT48716 IL1B Regulation of Gene_expression of SERPINE1 1 0.42 0.59 0.44
131 INT167619 Protein_catabolism of Ppp2cb Positive_regulation of App 1 0.00 0.88 0.44
132 INT201092 Binding of KNG1 and NGF 1 0.00 0.31 0.43
133 INT191610 Binding of App and Drd3 1 0.20 0.7 0.42
134 INT247599 Tlr4 Positive_regulation of Gene_expression of App 1 0.17 0.39 0.42
135 INT299040 Binding of COL7A1 and SPARC 1 0.02 0.7 0.42
136 INT201120 Binding of KNG1 and Par2 1 0.00 0.3 0.42
137 INT290269 KNG1 Positive_regulation of Binding of MID1 1 0.02 1.06 0.41
138 INT248242 Binding of COL7A1 and SDC1 1 0.00 0.76 0.41
139 INT139873 Negative_regulation of CTSB Negative_regulation of Gene_expression of App 1 0.00 0.8 0.41
140 INT290270 KNG1 Positive_regulation of MID1 1 0.02 1.06 0.41
141 INT83915 Il1b Positive_regulation of SERPINA3 1 0.02 0.5 0.41
142 INT248243 Binding of COL7A1 and SDC3 1 0.00 0.76 0.41
143 INT139874 CTSB Negative_regulation of Gene_expression of App 1 0.00 0.8 0.41
144 INT85511 Binding of KNG1 and Bdkrb2 1 0.54 0.51 0.4
145 INT69109 Acot1 Regulation of Gene_expression of Serpine2 1 0.04 0 0.4
146 INT79577 APP Negative_regulation of PENK 1 0.12 0.35 0.4
147 INT78121 Positive_regulation of Binding of App and 20S 1 0.23 0.61 0.4
148 INT78122 Binding of App and 20S 1 0.16 0.61 0.4
149 INT94853 TGFB1 Positive_regulation of Gene_expression of COL7A1 3 0.06 0.57 0.38
150 INT50624 Binding of Pebp1 and Opcml 2 0.13 0 0.38
151 INT323967 Il6 Positive_regulation of Gene_expression of App 1 0.10 0.86 0.38
152 INT220052 Binding of Col7a1 and Cia1 1 0.01 1.11 0.38
153 INT182052 Il18 Positive_regulation of Col7a1 1 0.03 0.74 0.38
154 INT48714 PTGER2 Negative_regulation of Gene_expression of SERPINE1 1 0.15 0.28 0.38
155 INT200469 Binding of COL7A1 and COMP 1 0.04 0.91 0.38
156 INT99738 Binding of F13A1 and Serpinf2 1 0.00 0.49 0.37
157 INT229222 Negative_regulation of ACE Negative_regulation of Protein_catabolism of KNG1 1 0.06 0.53 0.37
158 INT335994 Timp1 Regulation of Col7a1 1 0.01 0.36 0.37
159 INT78854 APP Positive_regulation of Localization of IL6 1 0.14 0.79 0.37
160 INT21828 Binding of POMC and Serpinb1a 1 0.02 0 0.36
161 INT26552 Gene_expression of Mras Positive_regulation of Gene_expression of KNG1 1 0.03 0.07 0.36
162 INT114903 POMC Regulation of Gene_expression of COL7A1 1 0.06 0.2 0.36
163 INT136007 Binding of INSRR and KNG1 1 0.00 0.17 0.34
164 INT230855 KNG1 Regulation of NOS1 2 0.03 0.94 0.33
165 INT214854 SERPINE1 Positive_regulation of PLAT 1 0.24 0.42 0.33
166 INT206609 Binding of Col7a1 and Ecm1 1 0.00 0.47 0.33
167 INT124376 Prodh2 Positive_regulation of App 1 0.00 0.66 0.33
168 INT56089 TGFB1 Regulation of SERPINE1 1 0.41 0.41 0.33
169 INT124379 Prodh2 Positive_regulation of Localization of App 1 0.00 0.66 0.33
170 INT56090 TNF Regulation of SERPINE1 1 0.43 0.41 0.33
171 INT156448 ANGPTL5 Positive_regulation of Gene_expression of COL7A1 1 0.00 0.46 0.33
172 INT230852 ACE Regulation of KNG1 2 0.03 0.72 0.32
173 INT180928 Binding of Col7a1 and Mmp9 1 0.03 0.96 0.32
174 INT308667 Binding of Chrm1 and Positive_regulation of Binding of App 1 0.04 1.14 0.32
175 INT312573 AMBP Negative_regulation of IL6 1 0.11 1.41 0.32
176 INT35216 Binding of KNG1 and Thop1 1 0.01 0 0.32
177 INT337327 KNG1 Positive_regulation of BDKRB2 1 0.21 0.4 0.32
178 INT312571 AMBP Negative_regulation of Positive_regulation of IL6 1 0.11 1.41 0.32
179 INT44985 KNG1 Positive_regulation of Rara 1 0.00 0.15 0.32
180 INT196618 Binding of KNG1 and Positive_regulation of NA 1 0.01 0.19 0.32
181 INT196623 Binding of KNG1 and Positive_regulation of DNAH8 1 0.01 0.19 0.32
182 INT147434 Psenen Positive_regulation of APP 1 0.01 0.58 0.32
183 INT170994 KNG1 Positive_regulation of Gene_expression of IL8 1 0.04 0.45 0.32
184 INT28688 Binding of Kng1 and Ctsl1 1 0.15 0 0.31
185 INT332255 Ptger2 Positive_regulation of Localization of Col7a1 1 0.00 0.92 0.31
186 INT65268 Igf1 Positive_regulation of Col7a1 1 0.48 0 0.3
187 INT96096 Binding of Serpinc1 and Selp 1 0.00 0.69 0.3
188 INT229635 SPINK5 Positive_regulation of NF1 1 0.01 2.17 0.3
189 INT15828 Ambp Regulation of Negative_regulation of Fn1 1 0.03 0 0.3
190 INT66243 KNG1 Positive_regulation of Ptgis 1 0.01 0 0.3
191 INT68977 App Positive_regulation of Localization of Mmp9 1 0.05 0.38 0.3
192 INT44984 KNG1 Regulation of Ltc4s 1 0.01 0.17 0.3
193 INT272925 Ccl2 Positive_regulation of Gene_expression of Col7a1 1 0.00 0.72 0.3
194 INT135095 Negative_regulation of CTSB Negative_regulation of APP 1 0.00 0.74 0.3
195 INT265826 Binding of ACE and SERPINE1 1 0.24 1.08 0.3
196 INT196641 Binding of KNG1 and Negative_regulation of DNAH8 1 0.01 0.19 0.29
197 INT56092 FGFR1 Positive_regulation of Transcription of SERPINE1 1 0.29 0.41 0.29
198 INT96101 Binding of SELP and Serpinc1 1 0.01 0.69 0.29
199 INT196612 Binding of KNG1 and Negative_regulation of NA 1 0.01 0.19 0.29
200 INT319220 FSIP1 Regulation of APP 1 0.29 1.46 0.29

Single Events

The table below shows the top 100 pain related interactions that have been reported for peptidase inhibitor activity. They are ordered first by their pain relevance and then by number of times they were reported in peptidase inhibitor activity. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT65500 Gene_expression of App 605 0.78 429.94 98.31
2 INT8357 Gene_expression of KNG1 153 0.75 77.26 68.66
3 INT7134 Localization of KNG1 127 0.79 65.73 67.97
4 INT11491 Positive_regulation of KNG1 128 0.67 60.41 58.74
5 INT9094 Gene_expression of COL7A1 277 0.77 143.42 38.73
6 INT60710 Gene_expression of Col7a1 217 0.78 113.2 35.2
7 INT29743 Negative_regulation of App 91 0.59 65.56 31.26
8 INT608 Negative_regulation of KNG1 98 0.43 72.36 31.23
9 INT47712 Positive_regulation of App 135 0.69 101.38 28.94
10 INT11361 Gene_expression of SERPINE1 183 0.78 136.45 27.97
11 INT3076 Regulation of KNG1 52 0.60 20.39 27.89
12 INT3167 Binding of KNG1 48 0.48 23.26 26.77
13 INT89662 Positive_regulation of Gene_expression of App 169 0.70 133.36 25.62
14 INT44954 Gene_expression of APP 191 0.78 105.86 23.9
15 INT11625 Localization of App 98 0.78 55.46 20.86
16 INT63164 Negative_regulation of Cst7 51 0.50 18.48 20.3
17 INT16794 Binding of App 103 0.48 64.87 19.79
18 INT65502 Regulation of App 77 0.62 52.05 19.44
19 INT65260 Positive_regulation of Col7a1 95 0.69 61.73 18.42
20 INT23657 Positive_regulation of APP 64 0.70 39.76 16.68
21 INT102680 Protein_catabolism of COL7A1 49 0.69 34.68 15.78
22 INT116465 Gene_expression of Birc5 241 0.78 192.31 15.32
23 INT11636 Positive_regulation of SERPINE1 85 0.69 68.73 14.8
24 INT54052 Gene_expression of App 33 0.78 25.08 14.7
25 INT15921 Positive_regulation of Serpine1 85 0.68 81.24 13.4
26 INT29745 Binding of APP 47 0.48 26.49 12.4
27 INT107916 Protein_catabolism of App 114 1.00 66.71 12.38
28 INT8629 Positive_regulation of COL7A1 72 0.69 40.66 12.09
29 INT65501 Regulation of Gene_expression of App 56 0.62 32.51 11.48
30 INT14204 Protein_catabolism of KNG1 41 0.96 20.94 11.47
31 INT98789 Negative_regulation of Gene_expression of App 54 0.58 40.27 11.15
32 INT2378 Negative_regulation of SERPINE1 47 0.59 34.55 9.9
33 INT41569 Regulation of APP 32 0.62 17.15 9.4
34 INT88559 Negative_regulation of Spink1 25 0.56 21.81 9.28
35 INT591 Negative_regulation of Serpinc1 44 0.57 31.73 8.82
36 INT26551 Positive_regulation of Gene_expression of KNG1 19 0.67 11.05 7.98
37 INT100661 Regulation of Cst7 18 0.53 5.93 7.8
38 INT15918 Gene_expression of Serpine1 60 0.62 41.73 7.72
39 INT56031 Positive_regulation of App 25 0.69 13.46 7.37
40 INT84932 Negative_regulation of APP 29 0.57 28.45 7.2
41 INT85764 Binding of PEBP1 9 0.44 4.52 7.2
42 INT15490 Negative_regulation of Gene_expression of COL7A1 40 0.58 25.97 7.18
43 INT16618 Negative_regulation of SERPING1 81 0.59 86.28 7.17
44 INT53704 Negative_regulation of Col7a1 42 0.35 22.4 6.88
45 INT22781 Binding of COL7A1 76 0.48 41.59 6.66
46 INT33781 Binding of Pebp1 11 0.44 1.76 6.61
47 INT16068 Gene_expression of SERPINB1 27 0.60 20.51 6.56
48 INT1280 Negative_regulation of Pebp1 7 0.28 2.12 6.45
49 INT166707 Protein_catabolism of Col7a1 24 0.74 20.47 6.39
50 INT60713 Binding of Col7a1 47 0.43 22.52 6.29
51 INT56374 Gene_expression of AMBP 34 0.54 35.85 6.25
52 INT103378 Binding of Spink1 24 0.40 15.3 6.19
53 INT65265 Positive_regulation of Gene_expression of Col7a1 48 0.69 23.81 6.16
54 INT25123 Negative_regulation of COL7A1 42 0.58 19.98 5.96
55 INT4587 Negative_regulation of Serping1 32 0.47 19.11 5.92
56 INT55101 Gene_expression of Cst7 16 0.75 2.39 5.92
57 INT21647 Negative_regulation of Positive_regulation of KNG1 11 0.43 5.54 5.73
58 INT11360 Localization of SERPINE1 41 0.80 33.98 5.61
59 INT63507 Gene_expression of SERPINE2 8 0.70 8.35 5.56
60 INT11480 Positive_regulation of Localization of KNG1 15 0.30 6.39 5.5
61 INT107173 Phosphorylation of App 20 0.82 12.64 5.3
62 INT134966 Localization of Col7a1 23 0.42 16.4 5.24
63 INT99823 Positive_regulation of Gene_expression of APP 31 0.70 21.52 5.09
64 INT115816 Protein_catabolism of APP 35 0.99 20.14 5.06
65 INT187295 Gene_expression of Serpinb1a 6 0.58 13.73 5.05
66 INT20200 Positive_regulation of Serpinc1 25 0.68 17.08 4.98
67 INT116464 Negative_regulation of Birc5 53 0.59 45.4 4.91
68 INT10138 Negative_regulation of Gene_expression of KNG1 13 0.57 9.57 4.9
69 INT15920 Regulation of Serpine1 34 0.42 17.36 4.89
70 INT9095 Regulation of Gene_expression of COL7A1 24 0.57 10.55 4.88
71 INT2072 Localization of AMBP 33 0.65 37.58 4.84
72 INT131692 Negative_regulation of Localization of App 9 0.53 4.69 4.82
73 INT37661 Negative_regulation of SERPINC1 48 0.59 38.6 4.77
74 INT144481 Gene_expression of SERPING1 55 0.77 50.4 4.75
75 INT3880 Negative_regulation of Serping1 54 0.58 37.19 4.75
76 INT6005 Gene_expression of Serpini1 5 0.58 1.62 4.74
77 INT57274 Positive_regulation of Gene_expression of COL7A1 50 0.69 24.19 4.72
78 INT35254 Negative_regulation of SERPINB1 22 0.48 11.42 4.7
79 INT2144 Localization of COL7A1 36 0.74 20.92 4.67
80 INT78116 Positive_regulation of Gene_expression of App 12 0.70 10.78 4.52
81 INT11354 Regulation of Gene_expression of SERPINE1 11 0.61 8.66 4.42
82 INT24439 Gene_expression of Spink1 19 0.63 10.05 4.35
83 INT11635 Positive_regulation of Gene_expression of SERPINE1 35 0.68 24.57 4.26
84 INT11634 Regulation of SERPINE1 24 0.62 20.06 4.26
85 INT58003 Localization of APP 32 0.80 13.75 4.2
86 INT49217 Positive_regulation of Positive_regulation of KNG1 7 0.41 3.64 4.18
87 INT3826 Positive_regulation of Tfpi 10 0.61 2.26 4.16
88 INT138872 Gene_expression of SPINK5 21 0.58 30.11 4.12
89 INT182311 Positive_regulation of Birc5 26 0.67 25.32 4.08
90 INT41942 Gene_expression of A2m 9 0.36 9.98 3.96
91 INT99821 Negative_regulation of Gene_expression of APP 20 0.42 15.21 3.94
92 INT17548 Negative_regulation of Serpine1 30 0.57 24.69 3.93
93 INT11627 Positive_regulation of Localization of App 14 0.62 6.27 3.64
94 INT99819 Negative_regulation of Positive_regulation of APP 6 0.58 4.41 3.64
95 INT24231 Localization of SERPINB1 13 0.61 3.1 3.61
96 INT27466 Negative_regulation of Kng1 7 0.10 7.79 3.56
97 INT157805 Negative_regulation of Gene_expression of Col7a1 22 0.34 12.85 3.51
98 INT70089 Negative_regulation of Binding of APP 7 0.59 6.45 3.44
99 INT220078 Positive_regulation of Negative_regulation of KNG1 3 0.13 5.03 3.41
100 INT8539 Negative_regulation of Serpina1a 21 0.58 12.65 3.39
101 INT14397 Gene_expression of Serpinc1 27 0.46 14.54 3.32
102 INT21572 Gene_expression of Pebp1 9 0.71 2.52 3.3
103 INT22092 Gene_expression of SERPINA3 17 0.75 11.57 3.16
104 INT37811 Negative_regulation of SERPINB6 8 0.47 4.65 3.15
105 INT14086 Binding of SERPINB1 18 0.34 4.32 3.13
106 INT37590 Regulation of COL7A1 15 0.54 9.4 3.12
107 INT20146 Localization of Tfpi 5 0.81 1.21 3.11
108 INT103246 Positive_regulation of Protein_catabolism of COL7A1 8 0.34 8.67 3.03
109 INT37405 Positive_regulation of Cst7 7 0.49 3.32 2.99
110 INT108773 Negative_regulation of Binding of App 10 0.42 7.26 2.96
111 INT54055 Regulation of Gene_expression of App 7 0.62 4.04 2.93
112 INT69099 Gene_expression of Serpine2 22 0.78 7.89 2.87
113 INT178772 Transcription of App 17 0.70 10.79 2.79
114 INT147429 Negative_regulation of Positive_regulation of App 8 0.40 8.73 2.78
115 INT54054 Binding of App 4 0.48 10.89 2.78
116 INT116463 Negative_regulation of Gene_expression of Birc5 40 0.59 33.99 2.74
117 INT64843 Gene_expression of Serping1 19 0.67 8.88 2.72
118 INT120372 Positive_regulation of Ambp 21 0.21 21.1 2.66
119 INT71794 Binding of SERPINC1 17 0.39 10.5 2.64
120 INT6928 Regulation of Tfpi 4 0.26 1.06 2.61
121 INT56376 Negative_regulation of AMBP 29 0.35 21.49 2.59
122 INT65258 Regulation of Gene_expression of Col7a1 17 0.55 8.26 2.57
123 INT156130 Binding of SERPING1 29 0.42 26.16 2.52
124 INT42039 Positive_regulation of Spink1 11 0.67 8.4 2.48
125 INT5180 Binding of Serpinc1 27 0.36 13.39 2.47
126 INT181986 Negative_regulation of Positive_regulation of Col7a1 6 0.08 7.4 2.46
127 INT60142 Negative_regulation of Serpinb1a 2 0.42 0.59 2.46
128 INT25121 Negative_regulation of Positive_regulation of COL7A1 5 0.24 1.32 2.37
129 INT22679 Binding of SERPINE1 25 0.36 17.33 2.36
130 INT162513 Regulation of Protein_catabolism of APP 5 0.51 1.79 2.36
131 INT4585 Gene_expression of Serping1 19 0.46 12.4 2.35
132 INT11626 Regulation of Localization of App 4 0.45 1.51 2.34
133 INT182312 Positive_regulation of Gene_expression of Birc5 26 0.69 25.3 2.32
134 INT56030 Regulation of App 8 0.62 4.06 2.32
135 INT160673 Gene_expression of Ambp 16 0.49 19.49 2.3
136 INT182318 Regulation of Birc5 25 0.60 23.58 2.29
137 INT56375 Positive_regulation of AMBP 25 0.60 21.24 2.22
138 INT43612 Regulation of SERPINB1 12 0.11 3.26 2.21
139 INT150640 Regulation of Binding of KNG1 3 0.35 1.31 2.2
140 INT227153 Negative_regulation of PEBP1 1 0.12 0.51 2.17
141 INT15922 Positive_regulation of Positive_regulation of Serpine1 6 0.31 8.34 2.16
142 INT70962 Positive_regulation of SERPING1 33 0.69 27.32 2.14
143 INT8237 Positive_regulation of Kng1 16 0.69 4.41 2.12
144 INT37809 Gene_expression of SERPINB6 7 0.77 6.58 2.12
145 INT124772 Regulation of Binding of App 6 0.45 4.92 2.09
146 INT130754 Gene_expression of Cast 21 0.78 11.6 2.08
147 INT11745 Protein_catabolism of Cst7 3 0.39 0.81 2.08
148 INT39008 Localization of App 13 0.77 9.07 2.05
149 INT63542 Positive_regulation of Serpini1 3 0.20 0.51 1.98
150 INT242856 Binding of Cst7 2 0.18 3.04 1.93
151 INT142774 Regulation of Phosphorylation of App 1 0.59 2.27 1.93
152 INT88375 Negative_regulation of Localization of KNG1 4 0.39 1.12 1.91
153 INT40954 Regulation of Serping1 5 0.32 3.71 1.88
154 INT13707 Positive_regulation of Pebp1 3 0.41 0.24 1.88
155 INT62349 Negative_regulation of Protein_catabolism of KNG1 8 0.42 6.47 1.86
156 INT48722 Negative_regulation of Gene_expression of SERPINE1 12 0.43 7.66 1.85
157 INT16391 Regulation of Serpinf2 5 0.03 4.22 1.82
158 INT6006 Positive_regulation of Gene_expression of Serpini1 1 0.00 0 1.82
159 INT3827 Gene_expression of Tfpi 5 0.53 0.36 1.81
160 INT121117 Regulation of Protein_catabolism of App 10 0.62 6.41 1.78
161 INT37810 Positive_regulation of Negative_regulation of SERPINB6 2 0.41 1.84 1.78
162 INT67183 Binding of Serpinb1a 4 0.37 4 1.77
163 INT107915 Regulation of Negative_regulation of App 6 0.45 4.47 1.76
164 INT41639 Positive_regulation of A2m 7 0.46 4.52 1.74
165 INT67604 Gene_expression of SERPINC1 14 0.67 11.47 1.72
166 INT82918 Binding of AMBP 23 0.39 23.31 1.71
167 INT156671 Gene_expression of Vcsa1 22 0.75 23.32 1.69
168 INT1347 Localization of Pebp1 2 0.48 0.17 1.69
169 INT48720 Transcription of SERPINE1 11 0.68 4.76 1.67
170 INT166131 Positive_regulation of Positive_regulation of Col7a1 8 0.46 6.4 1.65
171 INT20982 Positive_regulation of SERPINB1 7 0.28 7.27 1.61
172 INT74818 Transcription of KNG1 6 0.67 2.71 1.59
173 INT73330 Positive_regulation of SERPINB2 6 0.47 5.33 1.57
174 INT107132 Regulation of Localization of KNG1 2 0.22 0.96 1.55
175 INT133863 Positive_regulation of Protein_catabolism of App 12 0.59 7.53 1.52
176 INT58004 Positive_regulation of Localization of APP 5 0.46 2.1 1.5
177 INT23186 Positive_regulation of Positive_regulation of Tfpi 1 0.44 0 1.48
178 INT11710 Positive_regulation of SERPINC1 6 0.59 6.15 1.47
179 INT125871 Gene_expression of XIAP 5 0.65 11.46 1.46
180 INT25943 Transcription of App 5 0.53 1.79 1.44
181 INT125796 Regulation of Gene_expression of APP 8 0.59 5.95 1.41
182 INT129700 Regulation of Positive_regulation of App 3 0.43 1.86 1.41
183 INT72359 Binding of Serpini1 3 0.32 1.02 1.39
184 INT140296 Negative_regulation of XIAP 9 0.45 13.61 1.37
185 INT141529 Regulation of Positive_regulation of APP 3 0.44 0.31 1.34
186 INT65261 Regulation of Col7a1 18 0.55 8.7 1.33
187 INT24685 Localization of Serpine1 12 0.59 7.76 1.32
188 INT56944 Positive_regulation of SERPINA3 8 0.67 6.56 1.32
189 INT17052 Binding of SERPINB2 4 0.43 4.89 1.32
190 INT37076 Negative_regulation of Binding of KNG1 3 0.14 1.77 1.32
191 INT35728 Positive_regulation of Vcsa1 4 0.48 0.87 1.3
192 INT85765 Localization of PEBP1 3 0.73 0.83 1.3
193 INT13705 Regulation of Pebp1 2 0.26 0.85 1.3
194 INT41944 Positive_regulation of Gene_expression of A2m 2 0.23 2.56 1.29
195 INT69723 Gene_expression of SERPINB2 7 0.60 4.54 1.28
196 INT103488 Positive_regulation of Localization of App 5 0.50 3.05 1.28
197 INT53252 Gene_expression of Kng1 7 0.67 2.18 1.27
198 INT156672 Localization of SERPING1 10 0.74 12.15 1.25
199 INT200463 Regulation of SERPINB6 9 0.25 3.46 1.25
200 INT306702 Transcription of SERPINB6 1 0.01 0.24 1.25
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