GO:0030421

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Name defecation
Categary Process
Go Slim No
Go Link GO:0030421
Unique Molecular Interactions 54
Total Molecular Interactions 59
Total Single Events 503
Pain Genes Associated 2

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for defecation. They are ordered first by their pain relevance and then by number of times they were reported for defecation. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT41100 Mdk Positive_regulation of Localization of INS 1 0.01 0 1.55
2 INT41101 Mdk Negative_regulation of SST 1 0.02 0 1.53
3 INT103611 Mdk Negative_regulation of Phosphorylation of Sp1 1 0.01 0.28 0.88
4 INT97738 Mdk Positive_regulation of Mapk3 1 0.08 0.66 0.87
5 INT281091 Prkacb Positive_regulation of Mdk 1 0.02 0 0.62
6 INT281076 Adcy1 Positive_regulation of Mdk 1 0.07 0 0.62
7 INT166387 Binding of Gnb2l1 and Mdk 1 0.30 0.24 0.61
8 INT281086 Prkaca Positive_regulation of Mdk 1 0.08 0 0.61
9 INT49225 Mdk Regulation of Tac1 1 0.00 0 0.53
10 INT281982 Cyp3a23/3a1 Negative_regulation of Gene_expression of MDK 1 0.00 0.67 0.47
11 INT127400 Negative_regulation of Mdk Negative_regulation of Gene_expression of Elk1 1 0.01 0.71 0.45
12 INT127399 Negative_regulation of Mdk Negative_regulation of Positive_regulation of Nfkb1 1 0.02 0.7 0.45
13 INT127398 Negative_regulation of Mdk Negative_regulation of Gene_expression of Tacr1 1 0.01 0.71 0.45
14 INT127397 Negative_regulation of Mdk Negative_regulation of Gene_expression of Grin1 1 0.01 0.71 0.45
15 INT127396 Negative_regulation of Mdk Negative_regulation of Gene_expression of Grin2a 1 0.00 0.71 0.45
16 INT127401 Negative_regulation of Mdk Negative_regulation of Phosphorylation of Elk1 1 0.01 0.7 0.44
17 INT346218 Positive_regulation of Kras Positive_regulation of Phosphorylation of Mdk 1 0.01 0.71 0.42
18 INT291256 INS Negative_regulation of Positive_regulation of Mdk 1 0.01 1.65 0.39
19 INT302821 Mdk Negative_regulation of Il1 1 0.02 0.91 0.38
20 INT272726 Mdk Regulation of Negative_regulation of Prkca 1 0.00 0 0.38
21 INT304532 Binding of Mdk and Mapk1 1 0.02 0.63 0.35
22 INT304529 Negative_regulation of Binding of Mdk and Mapk1 1 0.02 0.63 0.35
23 INT190652 Mdk Positive_regulation of Phosphorylation of Mapk1 2 0.50 0.85 0.33
24 INT302841 Mdk Positive_regulation of Positive_regulation of TNF 1 0.01 0.35 0.33
25 INT223872 Mdk Regulation of Binding of Ltp 1 0.21 0 0.32
26 INT281981 Binding of MDK and Gtf3a 1 0.00 0.76 0.31
27 INT291242 Positive_regulation of Mdk Regulation of Mapk1 1 0.03 1.28 0.29
28 INT36571 MDK Positive_regulation of Localization of PRL 1 0.04 0.19 0.29
29 INT191328 Mir327 Negative_regulation of Mdk 1 0.00 0 0.28
30 INT281980 Scn9a Positive_regulation of MDK 1 0.06 0.24 0.26
31 INT281963 SCN11A Positive_regulation of MDK 1 0.12 0.24 0.26
32 INT291261 INS Positive_regulation of Phosphorylation of Mdk 1 0.01 0.28 0.25
33 INT291264 Mdk Regulation of Positive_regulation of MAPK1 1 0.02 0.61 0.21
34 INT291253 MAP3K3 Positive_regulation of Mdk 1 0.00 0.62 0.21
35 INT304530 Mknk1 Regulation of Mdk 1 0.01 0.19 0.2
36 INT190651 Mdk Negative_regulation of Positive_regulation of Mapk1 1 0.40 0.23 0.19
37 INT291239 Map3k8 Regulation of Positive_regulation of Mdk 1 0.08 0.53 0.11
38 INT267005 Negative_regulation of Mdk Negative_regulation of Gene_expression of Pdp1 1 0.02 0.09 0.07
39 INT267000 Mdk Negative_regulation of Positive_regulation of Baiap2 1 0.03 0.1 0.06
40 INT267004 Mdk Positive_regulation of Egr2 1 0.04 0.1 0.06
41 INT267001 Mdk Positive_regulation of Arc 1 0.02 0.1 0.06
42 INT347011 Negative_regulation of Mdk Negative_regulation of Regulation of Cd86 1 0.05 0 0.04
43 INT267006 Bdnf Positive_regulation of Mdk 1 0.07 0.18 0.03
44 INT194002 TRGC1 Negative_regulation of Mdk 1 0.00 0.14 0
45 INT266999 Mdk Positive_regulation of Regulation of Bdnf 1 0.07 0.05 0
46 INT254692 Positive_regulation of Map2k1 Regulation of Gene_expression of Mdk 1 0.05 0.42 0
47 INT226900 Binding of Mdk and Map3k8 1 0.05 0.14 0
48 INT294881 Phosphorylation of Mdk Regulation of Gene_expression of REXO1 1 0.02 0.48 0
49 INT199580 Braf Negative_regulation of Phosphorylation of Mdk 1 0.11 0.6 0
50 INT282607 POU5F1 Positive_regulation of Mdk 1 0.08 0.26 0
51 INT254686 Gene_expression of Map2k1 Regulation of Gene_expression of Mdk 1 0.08 0.42 0
52 INT225871 RAF1 Positive_regulation of Mdk 1 0.00 0 0
53 INT254688 Gene_expression of Map2k2 Regulation of Gene_expression of Mdk 1 0.09 0.42 0
54 INT175548 Mdk Positive_regulation of Rps6ka1 1 0.08 0.71 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for defecation. They are ordered first by their pain relevance and then by number of times they were reported in defecation. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT70437 Negative_regulation of Mdk 115 0.57 41.03 35.72
2 INT98647 Positive_regulation of Mdk 65 0.59 32.93 15.67
3 INT20066 Gene_expression of Mdk 38 0.76 21.41 13.4
4 INT245173 Gene_expression of MDK 81 0.49 51.08 6.78
5 INT36921 Regulation of Mdk 14 0.26 6.49 5.8
6 INT85075 Phosphorylation of Mdk 22 0.61 10.29 5.55
7 INT41099 Localization of Mdk 5 0.64 2.38 2.89
8 INT281978 Regulation of MDK 1 0.30 5.9 2.66
9 INT36923 Binding of Mdk 7 0.35 3.81 2.58
10 INT36920 Positive_regulation of Gene_expression of Mdk 8 0.49 2.03 2.53
11 INT190644 Regulation of Negative_regulation of Mdk 6 0.26 2.49 1.98
12 INT131572 Negative_regulation of Phosphorylation of Mdk 4 0.15 1.67 1.71
13 INT245172 Positive_regulation of Gene_expression of MDK 19 0.43 12.97 1.65
14 INT98648 Negative_regulation of Positive_regulation of Mdk 5 0.50 3.03 1.56
15 INT135665 Negative_regulation of Negative_regulation of Mdk 3 0.27 0.76 1.28
16 INT223121 Positive_regulation of Positive_regulation of Mdk 6 0.20 2.7 1.27
17 INT245174 Positive_regulation of MDK 4 0.30 5.05 1.17
18 INT207610 Positive_regulation of Phosphorylation of Mdk 7 0.26 2.66 1.15
19 INT281973 Regulation of Gene_expression of MDK 1 0.30 2.52 1.11
20 INT281977 Negative_regulation of Gene_expression of MDK 1 0.29 3.05 0.91
21 INT245171 Transcription of MDK 4 0.35 2.61 0.78
22 INT130891 Regulation of Gene_expression of Mdk 2 0.38 1.38 0.65
23 INT36922 Positive_regulation of Binding of Mdk 2 0.44 0.09 0.53
24 INT281979 Negative_regulation of MDK 1 0.21 1.4 0.5
25 INT190643 Regulation of Positive_regulation of Mdk 1 0.23 0.5 0.4
26 INT275045 Binding of MDK 2 0.15 1.32 0.31
27 INT281976 Regulation of Transcription of MDK 1 0.13 0.29 0.26
28 INT291229 Regulation of Phosphorylation of Mdk 1 0.06 0.33 0.26
29 INT281971 Negative_regulation of Negative_regulation of MDK 1 0.18 0.27 0.23
30 INT351552 Localization of MDK 1 0.47 0 0.11
31 INT337993 Negative_regulation of Transcription of Mdk 1 0.35 0.82 0
32 INT293719 Negative_regulation of Gene_expression of Mdk 1 0.05 0 0
33 INT337964 Transcription of Mdk 1 0.43 0.82 0
34 INT281761 Protein_catabolism of Mdk 1 0.10 0 0
35 INT175528 Regulation of Regulation of Mdk 1 0.15 1 0
36 INT293720 Positive_regulation of Negative_regulation of Mdk 1 0.05 0.07 0
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