GO:0030492

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Name hemoglobin binding
Categary Function
Go Slim No
Go Link GO:0030492
Unique Molecular Interactions 46
Total Molecular Interactions 58
Total Single Events 1110
Pain Genes Associated 10

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for hemoglobin binding. They are ordered first by their pain relevance and then by number of times they were reported for hemoglobin binding. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT117311 HP Positive_regulation of Lep 1 0.00 1.78 1.01
2 INT143323 Binding of HLA-B and HP 1 0.04 0.95 0.93
3 INT86430 IL6 Positive_regulation of Gene_expression of HP 1 0.15 3.61 0.83
4 INT56459 ADRA2C Positive_regulation of Localization of AHSP 1 0.23 0 0.78
5 INT44503 Cubn Positive_regulation of Prl 1 0.18 0 0.74
6 INT33575 ADRB1 Positive_regulation of Localization of Ahsp 1 0.00 0.33 0.73
7 INT82767 Binding of HP and MLRG 1 0.00 0 0.71
8 INT18231 Binding of ADRA1D and HP 2 0.14 0.17 0.64
9 INT26648 Binding of CEL and HP 1 0.04 0 0.58
10 INT117309 HP Positive_regulation of Gast 1 0.00 0.9 0.51
11 INT102214 ENG Negative_regulation of HP 1 0.01 0 0.49
12 INT102213 Binding of ENG and HP 1 0.01 0 0.47
13 INT117310 HP Regulation of Gbf1 1 0.00 0.86 0.46
14 INT159755 HP Regulation of OXA1L 1 0.01 0 0.44
15 INT38269 Binding of TCN1 and CUBN 1 0.00 0.28 0.4
16 INT29292 POMC Negative_regulation of HP 1 0.01 0 0.34
17 INT204071 HP Positive_regulation of Gene_expression of CDKN2A 1 0.00 3.48 0.34
18 INT204080 HP Negative_regulation of Phosphorylation of Rb1 1 0.00 3.53 0.34
19 INT273130 Negative_regulation of Binding of Drd2 and Hp 1 0.05 0 0.28
20 INT273129 Binding of Drd2 and Hp 1 0.04 0 0.28
21 INT145542 HP Negative_regulation of Positive_regulation of TRPV1 1 0.00 0.07 0.27
22 INT206427 Binding of HP and SULT1A3 1 0.03 0 0.27
23 INT45196 Cubn Negative_regulation of Prl 1 0.05 0 0.27
24 INT29959 Ahsp Positive_regulation of Npr1 1 0.00 0.18 0.17
25 INT308551 Binding of HP and VPS45 1 0.04 0.44 0.15
26 INT295273 STAT1 Regulation of Transcription of Hp 1 0.00 0.63 0.15
27 INT31697 Binding of HP and PTGER1 1 0.01 0 0.15
28 INT295272 STAT1 Regulation of Hp 1 0.00 0.63 0.14
29 INT178351 Binding of Il6 and Hp 1 0.00 0.61 0.14
30 INT17014 AHSP Positive_regulation of Positive_regulation of RTCA 1 0.07 1.11 0.14
31 INT18230 Binding of HP and WWOX 1 0.19 0.17 0.13
32 INT344947 IPP Regulation of HP 1 0.03 0.81 0.12
33 INT344965 Phc1 Regulation of HP 1 0.02 0.95 0.09
34 INT304189 Binding of HP and ADHD1 1 0.02 2.59 0.07
35 INT285402 HP Positive_regulation of Gene_expression of ROS1 1 0.00 0.51 0.05
36 INT204079 HP Positive_regulation of Gene_expression of Cdkn1b 1 0.00 0.6 0.05
37 INT47870 Hpd Regulation of Hbb 1 0.20 0.06 0.03
38 INT304190 Binding of HP and ZFP91 1 0.00 2.74 0.03
39 INT288983 Binding of DEFB1 and HPR 1 0.01 0 0
40 INT344964 Phc1 Positive_regulation of HP 1 0.04 1.36 0
41 INT213176 Binding of HP and SHBG 1 0.02 1.07 0
42 INT204076 HP Positive_regulation of Gene_expression of Fas 1 0.00 1.81 0
43 INT213175 Binding of DBP and HP 1 0.03 1.08 0
44 INT318329 Binding of HBA1 and HBB 1 0.02 1 0
45 INT320054 Binding of C2 and Hbb 1 0.00 0 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for hemoglobin binding. They are ordered first by their pain relevance and then by number of times they were reported in hemoglobin binding. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT1721 Negative_regulation of HP 148 0.42 86.82 16.89
2 INT8548 Gene_expression of HP 86 0.77 47.62 11.94
3 INT192967 Gene_expression of Hp 14 0.43 8.06 11.01
4 INT273123 Binding of Hp 1 0.25 3.56 10.9
5 INT6125 Localization of Ahsp 35 0.78 9.17 9.42
6 INT8249 Positive_regulation of Cubn 15 0.66 4.05 9.35
7 INT13893 Negative_regulation of Cubn 9 0.36 1.78 9.24
8 INT4159 Gene_expression of Hp 33 0.72 12.49 8.39
9 INT3401 Positive_regulation of Hp 22 0.69 16.33 7.97
10 INT14043 Binding of HP 52 0.30 26.56 7.76
11 INT32709 Negative_regulation of Hbb 30 0.54 18.27 6.97
12 INT63177 Regulation of HP 71 0.44 39.48 5.86
13 INT18011 Positive_regulation of HP 60 0.50 31.88 4.75
14 INT23045 Positive_regulation of Hbb 31 0.64 19.35 4.54
15 INT17020 Localization of AHSP 11 0.80 3.82 4.34
16 INT44578 Binding of Hbb 19 0.48 3.12 4.2
17 INT6126 Gene_expression of Ahsp 16 0.67 7.72 4.08
18 INT192970 Negative_regulation of Hp 7 0.22 6.99 4.06
19 INT18822 Regulation of Cubn 4 0.27 0.17 3.74
20 INT23044 Gene_expression of Hbb 13 0.43 5.77 3.1
21 INT12410 Negative_regulation of Ahsp 10 0.29 3.49 3.07
22 INT21299 Negative_regulation of Hp 14 0.44 10.97 2.97
23 INT15288 Regulation of Hp 11 0.60 3.68 2.89
24 INT192964 Positive_regulation of Hp 7 0.28 2 2.75
25 INT4647 Regulation of Hbb 10 0.60 5.28 2.66
26 INT33243 Localization of HP 17 0.12 9.7 2.2
27 INT195191 Gene_expression of Cubn 2 0.06 0 2.17
28 INT130392 Positive_regulation of Gene_expression of HP 7 0.69 7.34 1.9
29 INT41633 Positive_regulation of Positive_regulation of Cubn 2 0.48 0.1 1.89
30 INT19265 Negative_regulation of Localization of AHSP 3 0.59 0.62 1.69
31 INT192968 Positive_regulation of Gene_expression of Hp 2 0.28 1.34 1.44
32 INT273128 Protein_catabolism of Hp 3 0.47 2.2 1.39
33 INT49978 Localization of Hbb 4 0.39 1.11 1.29
34 INT21950 Positive_regulation of Localization of Ahsp 5 0.44 0.81 1.28
35 INT257952 Positive_regulation of CUBN 1 0.07 0.61 1.22
36 INT44498 Localization of Cubn 2 0.34 0.38 1.19
37 INT41333 Negative_regulation of Positive_regulation of Cubn 2 0.15 0.47 1.12
38 INT17627 Binding of Ahsp 3 0.25 1.83 1.04
39 INT8231 Positive_regulation of Gene_expression of Ahsp 2 0.04 1.16 1
40 INT3402 Positive_regulation of Positive_regulation of Hp 2 0.49 1.05 1
41 INT273124 Positive_regulation of Negative_regulation of Hp 1 0.26 0.54 0.91
42 INT110548 Regulation of Gene_expression of Hbb 2 0.16 0.65 0.81
43 INT273125 Positive_regulation of Localization of Hp 1 0.26 0.45 0.78
44 INT273127 Localization of Hp 1 0.39 0.45 0.77
45 INT35804 Regulation of Gene_expression of Hp 3 0.34 0.68 0.75
46 INT44500 Regulation of Localization of Cubn 1 0.20 0 0.75
47 INT19154 Negative_regulation of Localization of Ahsp 4 0.22 2.07 0.73
48 INT295416 Regulation of Positive_regulation of Hbb 1 0.04 1.92 0.73
49 INT17021 Negative_regulation of AHSP 5 0.43 3.45 0.72
50 INT295417 Negative_regulation of Positive_regulation of Hbb 1 0.04 1.92 0.72
51 INT257951 Localization of CUBN 1 0.07 0 0.71
52 INT257948 Binding of CUBN 1 0.05 0 0.7
53 INT192963 Transcription of Hp 2 0.39 1.32 0.67
54 INT17018 Positive_regulation of Localization of AHSP 3 0.70 0.6 0.66
55 INT13894 Regulation of Negative_regulation of Cubn 1 0.13 0.09 0.63
56 INT192969 Negative_regulation of Gene_expression of Hp 1 0.32 1.06 0.59
57 INT124269 Binding of Cubn 1 0.28 0.2 0.59
58 INT273122 Positive_regulation of Positive_regulation of Hp 1 0.26 0.08 0.58
59 INT273126 Positive_regulation of Binding of Hp 1 0.26 0.08 0.58
60 INT164537 Negative_regulation of Gene_expression of Hbb 2 0.06 1.47 0.55
61 INT192966 Positive_regulation of Transcription of Hp 1 0.38 0.82 0.55
62 INT15294 Regulation of Ahsp 2 0.37 0.65 0.5
63 INT17019 Positive_regulation of AHSP 3 0.70 1.85 0.49
64 INT128569 Regulation of Positive_regulation of Cubn 1 0.09 0 0.49
65 INT19212 Positive_regulation of Gene_expression of Hp 5 0.15 1.47 0.46
66 INT55144 Negative_regulation of Gene_expression of Ahsp 3 0.16 1.39 0.44
67 INT143240 Positive_regulation of HPR 2 0.08 1.93 0.43
68 INT128793 Gene_expression of HBB 16 0.78 10.69 0.42
69 INT15295 Positive_regulation of Regulation of Ahsp 1 0.41 0.41 0.42
70 INT15786 Gene_expression of AHSP 8 0.78 5.12 0.4
71 INT206454 Positive_regulation of Localization of HP 2 0.05 0.82 0.39
72 INT101790 Positive_regulation of Positive_regulation of Hbb 2 0.25 1.82 0.38
73 INT21949 Positive_regulation of Ahsp 4 0.61 1.27 0.35
74 INT183920 Localization of Hp 1 0.29 0.93 0.33
75 INT45869 Negative_regulation of Gene_expression of Hp 1 0.42 0.65 0.31
76 INT183911 Negative_regulation of Phosphorylation of Hp 1 0.17 0.86 0.3
77 INT46932 Positive_regulation of Binding of HP 1 0.36 1.67 0.28
78 INT183919 Positive_regulation of Phosphorylation of Hp 1 0.20 0.8 0.28
79 INT183914 Phosphorylation of Hp 1 0.32 0.78 0.27
80 INT103580 Negative_regulation of Negative_regulation of HP 1 0.01 0.71 0.24
81 INT17017 Negative_regulation of Gene_expression of AHSP 1 0.43 2.12 0.23
82 INT103581 Negative_regulation of Regulation of HP 1 0.02 0.77 0.22
83 INT46744 Gene_expression of HPR 3 0.47 1.66 0.19
84 INT213242 Negative_regulation of Gene_expression of HP 3 0.04 0.88 0.17
85 INT189236 Transcription of HP 4 0.28 3.07 0.16
86 INT66444 Regulation of Gene_expression of HP 4 0.45 3.48 0.15
87 INT156610 Negative_regulation of HBB 2 0.37 1.25 0.15
88 INT213241 Regulation of Regulation of HP 2 0.03 1.26 0.12
89 INT17022 Regulation of AHSP 1 0.24 0.89 0.1
90 INT34737 Negative_regulation of Positive_regulation of Ahsp 1 0.37 0.25 0.09
91 INT344957 Regulation of Negative_regulation of HP 1 0.07 2.9 0.08
92 INT73065 Regulation of Localization of Ahsp 1 0.03 0.27 0.08
93 INT304199 Negative_regulation of Positive_regulation of HP 1 0.04 1.72 0.08
94 INT166835 Regulation of HBB 1 0.02 1.08 0.08
95 INT107290 Regulation of Positive_regulation of HP 1 0.33 0.07 0.07
96 INT164958 Regulation of Gene_expression of HBB 1 0.44 0.59 0.07
97 INT230731 Positive_regulation of Negative_regulation of Hbb 1 0.01 0.52 0.07
98 INT128794 Negative_regulation of Gene_expression of HBB 1 0.59 5.98 0.06
99 INT12411 Negative_regulation of Negative_regulation of Ahsp 1 0.05 0.22 0.06
100 INT38615 Positive_regulation of Negative_regulation of HP 1 0.01 0.64 0.04
101 INT204158 Positive_regulation of Gene_expression of Hbb 1 0.02 0.57 0.04
102 INT308562 Regulation of Localization of HP 2 0.07 2.11 0.03
103 INT207238 Binding of HBB 4 0.36 1.13 0
104 INT206452 Negative_regulation of Binding of HP 2 0.04 0.84 0
105 INT213240 Positive_regulation of Regulation of HP 2 0.02 1.05 0
106 INT157703 Positive_regulation of Positive_regulation of HP 2 0.42 0.76 0
107 INT206443 Phosphorylation of HP 1 0.06 0 0
108 INT354644 Gene_expression of CUBN 1 0.65 0.32 0
109 INT17016 Binding of AHSP 1 0.31 0.58 0
110 INT297581 Localization of HPR 1 0.25 0.91 0
111 INT189276 Positive_regulation of HBB 1 0.42 0 0
112 INT50455 Positive_regulation of Regulation of Hp 1 0.08 0.08 0
113 INT207234 Transcription of HBB 1 0.28 0 0
114 INT247471 Negative_regulation of Binding of Hbb 1 0.03 0.95 0
115 INT320049 Regulation of Binding of Hbb 1 0.02 0 0
116 INT15785 Positive_regulation of Gene_expression of AHSP 1 0.45 0.32 0
117 INT279986 Protein_catabolism of HP 1 0.18 0.23 0
118 INT318136 Positive_regulation of Gene_expression of HBB 1 0.04 2.65 0
119 INT210076 Localization of HBB 1 0.15 0 0
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