GO:0030509

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Name BMP signaling pathway
Categary Process
Go Slim No
Go Link GO:0030509
Unique Molecular Interactions 501
Total Molecular Interactions 660
Total Single Events 4718
Pain Genes Associated 51

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for BMP signaling pathway. They are ordered first by their pain relevance and then by number of times they were reported for BMP signaling pathway. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT250867 Fgf8 Positive_regulation of Protein_catabolism of Ecm1 1 0.06 4.35 2.14
2 INT134215 CRH Positive_regulation of ENG 1 0.13 1.22 2.06
3 INT31445 ENG Positive_regulation of Localization of Prl 4 0.01 0 1.77
4 INT167321 Binding of ENG and OPRM1 1 0.27 0.63 1.76
5 INT199503 ENG Positive_regulation of Oprk1 1 0.01 0.87 1.69
6 INT45306 Pomc Positive_regulation of ENG 2 0.07 1.11 1.68
7 INT199504 ENG Positive_regulation of Oprm1 1 0.01 0.87 1.68
8 INT45307 ENG Positive_regulation of Localization of Avp 1 0.00 0 1.45
9 INT15846 Crh Positive_regulation of Localization of ENG 3 0.07 0.42 1.38
10 INT89878 Pdyn Positive_regulation of Gene_expression of Nkx2-5 1 0.35 0 1.29
11 INT89873 Pdyn Positive_regulation of Gene_expression of Gata4 1 0.23 0 1.29
12 INT89876 Pdyn Positive_regulation of Gata4 1 0.23 0 1.28
13 INT287104 Binding of Ntrk2 and T 1 0.20 3.29 1.26
14 INT280949 Binding of Fst and Inhbe 3 0.01 2.51 1.15
15 INT31444 ENG Positive_regulation of Prl 1 0.01 0 1.14
16 INT229913 Positive_regulation of Ntsr1 Positive_regulation of Gene_expression of Egr1 1 0.12 1.33 1.11
17 INT167819 IFNA1 Positive_regulation of Fst 1 0.39 0 1.07
18 INT146897 Binding of Fst and OR13H1 1 0.01 0 1.05
19 INT134213 CRH Positive_regulation of Gene_expression of ENG 1 0.13 0.61 1.03
20 INT229914 Egr1 Positive_regulation of Phosphorylation of Mapk3 1 0.46 1.03 1.02
21 INT61860 Akr1d1 Regulation of Egr1 1 0.01 0 0.96
22 INT61861 Akr1d1 Regulation of Positive_regulation of Egr1 1 0.01 0 0.96
23 INT165941 Bmp7 Positive_regulation of Penk 1 0.28 0.43 0.95
24 INT165942 Bmp7 Positive_regulation of Transcription of Pomc 1 0.29 0.43 0.95
25 INT165940 Bmp7 Positive_regulation of Pomc 1 0.29 0.43 0.95
26 INT210783 Bmp2 Positive_regulation of Tnip1 1 0.40 0.53 0.94
27 INT250868 Fgf8 Positive_regulation of Gene_expression of Mmp3 1 0.15 1.73 0.93
28 INT210791 Bmp2 Positive_regulation of Net1 1 0.38 0.52 0.93
29 INT210799 Bmp2 Positive_regulation of B2m 1 0.35 0.52 0.92
30 INT61859 Akr1d1 Positive_regulation of Egr1 1 0.01 0 0.92
31 INT61862 Slc3a1 Positive_regulation of Egr1 1 0.05 0 0.92
32 INT32187 Binding of ENG and Negative_regulation of Localization of LH 1 0.01 0 0.91
33 INT291011 Pomc Regulation of Gene_expression of ENG 1 0.08 0.86 0.91
34 INT250861 Fgf8 Positive_regulation of Gene_expression of Ptger2 1 0.04 1.51 0.84
35 INT278690 LEF1 Negative_regulation of Gene_expression of IK 1 0.00 0.66 0.83
36 INT278697 LEF1 Negative_regulation of STAT6 1 0.00 0.44 0.78
37 INT123494 Binding of Egr1 and Ccr5 1 0.04 0.94 0.71
38 INT287099 Binding of Bdnf and T 1 0.10 1.1 0.69
39 INT92025 Egr1 Positive_regulation of Jun 1 0.15 0.61 0.67
40 INT92026 Egr1 Positive_regulation of Fos 1 0.50 0.61 0.67
41 INT137102 Fst Regulation of Sec22b 1 0.07 0 0.67
42 INT137101 Fst Regulation of Htr1a 1 0.24 0 0.67
43 INT89875 Pdyn Positive_regulation of Localization of Myh6 1 0.09 0 0.66
44 INT32719 ENG Regulation of LH 2 0.00 0 0.64
45 INT312106 EGR1 Regulation of Gene_expression of PTGES 1 0.31 1.06 0.64
46 INT89877 Pdyn Positive_regulation of Nkx2-5 1 0.11 0 0.64
47 INT31443 ENG Positive_regulation of Localization of Pomc 1 0.00 0 0.63
48 INT98629 VEGFA Positive_regulation of Gene_expression of EGR1 1 0.52 0.42 0.61
49 INT98628 VEGFA Positive_regulation of Transcription of EGR1 1 0.52 0.42 0.61
50 INT144320 Binding of Fst and Rbm39 1 0.04 0 0.59
51 INT109065 Pdyn Positive_regulation of Gene_expression of Gata4 1 0.00 0 0.58
52 INT115146 MAPK1 Positive_regulation of EGR1 3 0.13 2.43 0.57
53 INT305744 Fst Positive_regulation of Creb1 1 0.12 0.33 0.57
54 INT261478 Positive_regulation of Ephb1 Regulation of Gene_expression of Egr1 1 0.10 0.23 0.55
55 INT250852 Fgf8 Negative_regulation of Gene_expression of Ecm1 1 0.04 1.1 0.54
56 INT134214 CRH Regulation of Localization of ENG 1 0.14 0.39 0.53
57 INT32151 ENG Positive_regulation of Gene_expression of IFNA1 1 0.37 0 0.53
58 INT32291 ENG Negative_regulation of LH 2 0.00 0 0.52
59 INT171897 Binding of Bmpr2 and Il1 1 0.03 0.84 0.52
60 INT30618 Slc3a1 Regulation of ENG 1 0.00 0 0.5
61 INT135751 Pomc Positive_regulation of Positive_regulation of Id1 1 0.19 0 0.5
62 INT30619 Pomc Regulation of ENG 1 0.00 0 0.5
63 INT135753 Pomc Positive_regulation of Gene_expression of Id1 1 0.17 0 0.5
64 INT135754 Pomc Positive_regulation of Id1 1 0.17 0 0.5
65 INT102214 ENG Negative_regulation of HP 1 0.01 0 0.49
66 INT60872 Binding of ENG and Abat 1 0.00 0 0.49
67 INT60871 ENG Regulation of Localization of LH 1 0.00 0 0.49
68 INT43695 ENG Regulation of Regulation of Prl 1 0.00 0 0.47
69 INT60870 ENG Negative_regulation of Localization of LH 1 0.00 0 0.47
70 INT102213 Binding of ENG and HP 1 0.01 0 0.47
71 INT210793 Bmp2 Positive_regulation of Tsc22d3 1 0.32 0.26 0.46
72 INT202516 Positive_regulation of Binding of ENG and Penk 1 0.03 0.58 0.42
73 INT202515 Binding of ENG and Penk 1 0.02 0.57 0.41
74 INT81991 Bmpr2 Positive_regulation of Gene_expression of ODF1 1 0.03 1.59 0.41
75 INT32720 Negative_regulation of ENG Regulation of LH 1 0.00 0 0.41
76 INT204793 T Positive_regulation of Mthfd1 1 0.00 1.32 0.39
77 INT250870 Fgf8 Positive_regulation of Ecm1 1 0.04 0.79 0.38
78 INT130930 Egr1 Negative_regulation of Positive_regulation of Thbs1 1 0.58 0.64 0.38
79 INT123495 Negative_regulation of Binding of Egr1 and Ccr5 1 0.03 0.48 0.36
80 INT123493 Regulation of Binding of Egr1 and Ccr5 1 0.03 0.48 0.36
81 INT90722 Nr4a1 Positive_regulation of Egr1 1 0.20 0.48 0.35
82 INT168202 Msx1 Negative_regulation of Gene_expression of Mc1r 1 0.21 0.49 0.35
83 INT312124 EGR1 Regulation of Binding of PTGES 1 0.31 0.41 0.35
84 INT90723 Nr4a2 Positive_regulation of Egr1 1 0.22 0.49 0.35
85 INT90724 Egr3 Positive_regulation of Egr1 1 0.33 0.48 0.35
86 INT144966 MAPK1 Positive_regulation of Localization of EGR1 1 0.08 0.83 0.35
87 INT194860 BMPR2 Positive_regulation of IL1B 1 0.01 0.61 0.34
88 INT209312 Trpc5 Positive_regulation of Gene_expression of Scx 1 0.15 0.05 0.33
89 INT126097 Ddc Positive_regulation of Egr1 1 0.08 0 0.32
90 INT224687 Il1 Positive_regulation of Bmp2 1 0.00 0.3 0.31
91 INT55404 Binding of ENG and Th 1 0.02 0 0.3
92 INT166165 Binding of TGFB3 and Bmp2 1 0.00 0 0.3
93 INT250856 Fgf8 Positive_regulation of Localization of Mmp3 1 0.11 0.51 0.3
94 INT109067 Pdyn Positive_regulation of Gene_expression of NKX2-5 1 0.01 0 0.29
95 INT74334 Penk Regulation of Transcription of Egr1 1 0.40 0.25 0.29
96 INT75056 Binding of MC1R and Msx1 1 0.00 0.17 0.29
97 INT29137 ENG Regulation of POMC 1 0.00 0 0.28
98 INT74336 Crh Regulation of Transcription of Egr1 1 0.49 0.24 0.28
99 INT147356 Egr1 Positive_regulation of Gene_expression of Btg1 1 0.14 1.56 0.28
100 INT182817 EEF1A2 Positive_regulation of BMP2 1 0.26 1.62 0.28
101 INT29139 ENG Regulation of Oprl1 1 0.00 0 0.28
102 INT216127 EGR1 Regulation of Transcription of TP53 1 0.06 0.21 0.28
103 INT250864 Fgf8 Positive_regulation of Positive_regulation of Ptger2 1 0.03 0.55 0.28
104 INT250854 Fgf8 Positive_regulation of Positive_regulation of Mmp3 1 0.11 0.55 0.28
105 INT147358 Egr1 Positive_regulation of Gene_expression of Gdf15 1 0.14 1.56 0.28
106 INT58182 Fos Regulation of Egr1 1 0.49 0.09 0.27
107 INT147359 Positive_regulation of Pik3cd Positive_regulation of Egr1 1 0.09 1.51 0.27
108 INT216128 EGR1 Regulation of TP53 1 0.11 0.21 0.27
109 INT130931 Sis Negative_regulation of Egr1 1 0.01 0.52 0.27
110 INT58176 Junb Regulation of Egr1 1 0.46 0.09 0.27
111 INT147360 Pik3cd Positive_regulation of Egr1 1 0.12 1.51 0.27
112 INT32156 Binding of ENG and Oprd1 1 0.00 0 0.26
113 INT32149 Binding of ENG and LLGL1 1 0.11 0 0.26
114 INT125521 EGR1 Regulation of GDF15 1 0.13 0.47 0.26
115 INT118461 Bmp7 Positive_regulation of Th 1 0.31 0.06 0.25
116 INT168203 Binding of Mc1r and Msx1 1 0.19 0.64 0.25
117 INT212568 Fst Regulation of Gene_expression of Il2 1 0.30 0.07 0.24
118 INT98631 Negative_regulation of VEGFA Positive_regulation of EGR1 1 0.44 0.18 0.24
119 INT130060 PPARG Positive_regulation of Positive_regulation of Egr1 1 0.22 0.46 0.24
120 INT98630 VEGFA Positive_regulation of EGR1 1 0.52 0.18 0.24
121 INT144967 MAPK1 Positive_regulation of Positive_regulation of EGR1 1 0.08 0.63 0.24
122 INT43713 ENG Regulation of Prl 1 0.00 0 0.23
123 INT287098 Binding of FL and T 1 0.10 0.66 0.23
124 INT250873 Fgf8 Positive_regulation of GAG 1 0.55 0.48 0.23
125 INT184162 Egr1 Positive_regulation of Transcription of Ptges2 1 0.08 0.42 0.22
126 INT184160 Binding of Egr1 and Ptges2 1 0.07 0.4 0.22
127 INT271853 Ngf Positive_regulation of Gene_expression of Egr1 1 0.53 1.36 0.21
128 INT75057 Binding of POMC and Msx1 2 0.39 0.6 0.2
129 INT259817 Ltp Positive_regulation of Egr1 1 0.03 0.28 0.2
130 INT287894 VEGFA Positive_regulation of Localization of BMP4 1 0.04 2.49 0.2
131 INT259812 Gtf3a Regulation of Egr1 1 0.01 0.58 0.19
132 INT184159 Egr1 Positive_regulation of Ptges2 1 0.07 0.34 0.19
133 INT58178 Gtf3a Positive_regulation of Egr1 1 0.07 0.09 0.19
134 INT287097 T Positive_regulation of Ntrk2 1 0.21 0.6 0.19
135 INT184161 Negative_regulation of Egr1 Positive_regulation of Ptges2 1 0.07 0.34 0.19
136 INT259814 Binding of Arc and Egr1 1 0.34 0.55 0.19
137 INT259813 Binding of Egr1 and Arc 1 0.32 0.55 0.19
138 INT149096 PITX2 Positive_regulation of Gene_expression of Egr1 1 0.01 1.23 0.19
139 INT58181 Gtf3a Positive_regulation of Gene_expression of Egr1 1 0.07 0.1 0.19
140 INT312090 EGR1 Regulation of Positive_regulation of PTGES 1 0.42 0.21 0.18
141 INT317895 Fos Regulation of Transcription of Egr1 1 0.41 1.03 0.17
142 INT317897 Egr1 Regulation of Transcription of Fosb 1 0.34 1.08 0.17
143 INT333449 Binding of SMAD2 and SMAD4 1 0.23 0 0.17
144 INT317892 Egr1 Regulation of Transcription of Fos 1 0.41 1.03 0.17
145 INT312109 ELANE Positive_regulation of EGR1 1 0.15 0.23 0.16
146 INT312100 ELANE Positive_regulation of Binding of EGR1 1 0.16 0.23 0.16
147 INT251347 Binding of Bmpr2 and Limk1 1 0.18 1.51 0.16
148 INT146025 EGR1 Negative_regulation of Gene_expression of GDF15 1 0.28 0.81 0.15
149 INT97547 KITLG Negative_regulation of Msx1 1 0.00 0.08 0.15
150 INT97542 Pomc Negative_regulation of Msx1 1 0.13 0.07 0.15
151 INT312092 ELANE Positive_regulation of Gene_expression of EGR1 1 0.19 0.21 0.15
152 INT168806 Tlr4 Positive_regulation of Gene_expression of Egr1 1 0.18 0.3 0.15
153 INT97545 Gtf3a Negative_regulation of Msx1 1 0.02 0.08 0.15
154 INT123180 Bmp6 Positive_regulation of Lamtor1 1 0.01 0.61 0.14
155 INT123192 Bmp6 Positive_regulation of CDKN1A 1 0.18 0.61 0.14
156 INT213551 Proc Regulation of Bmp7 1 0.00 0.15 0.14
157 INT123194 Bmp6 Positive_regulation of TAF9 1 0.18 0.61 0.14
158 INT250863 Fgf8 Positive_regulation of Ptger2 1 0.03 0.19 0.14
159 INT88410 BMP7 Negative_regulation of CDK2 1 0.35 0 0.14
160 INT314852 Binding of Cdkn2a and Tgfbr3 1 0.28 1.15 0.14
161 INT314859 Binding of Cdkn2b and Tgfbr3 1 0.33 1.16 0.14
162 INT123193 Bmp6 Positive_regulation of Negative_regulation of TAF9 1 0.18 0.61 0.14
163 INT115140 PPARG Positive_regulation of EGR1 1 0.36 0.45 0.13
164 INT247267 Binding of Egr1 and Mecp2 1 0.12 0.18 0.13
165 INT321408 INS Positive_regulation of EGR1 1 0.03 2.36 0.13
166 INT32294 ENG Positive_regulation of Trh 1 0.01 0 0.13
167 INT115141 TGM7 Positive_regulation of EGR1 1 0.26 0.44 0.13
168 INT311905 Binding of Runx2 and Smad1 1 0.12 0.46 0.13
169 INT321414 INS Positive_regulation of Transcription of EGR1 1 0.03 2.36 0.13
170 INT311912 Gene_expression of Smad1 Positive_regulation of Gene_expression of Mmp13 1 0.08 0.51 0.12
171 INT321410 EGR1 Negative_regulation of Gene_expression of TNFSF10 1 0.10 2.07 0.12
172 INT214150 Binding of Mc3r and Msx1 1 0.03 0.5 0.12
173 INT172976 Mras Regulation of Gene_expression of Smad4 1 0.00 0.83 0.12
174 INT226532 T Positive_regulation of Gene_expression of IFNA1 1 0.01 0.15 0.12
175 INT154803 Gene_expression of EGR1 Positive_regulation of Positive_regulation of GDF15 1 0.33 0.84 0.12
176 INT326974 BMP2 Positive_regulation of Gene_expression of COL2A1 1 0.07 0.27 0.11
177 INT250866 Binding of Fgfr4 and Fgf8 1 0.12 0.35 0.11
178 INT214152 Binding of Mc4r and Msx1 1 0.03 0.24 0.11
179 INT208938 Positive_regulation of Tacr1 Positive_regulation of Nkx2-5 1 0.17 0 0.1
180 INT250860 Fgf8 Regulation of Localization of Ptger2 1 0.02 0.13 0.1
181 INT287887 WNT1 Positive_regulation of Localization of BMP4 1 0.04 1.13 0.1
182 INT60399 ENG Regulation of Localization of Prl 1 0.04 0.57 0.1
183 INT250862 Fgf8 Regulation of Localization of Mmp3 1 0.13 0.13 0.1
184 INT238038 Binding of BMP2 and OPLL 1 0.20 2.45 0.09
185 INT250859 Fgf8 Negative_regulation of Gene_expression of Mmp3 1 0.09 0.12 0.09
186 INT250872 Fgf8 Positive_regulation of Mmp3 1 0.11 0.12 0.09
187 INT158011 KLRF1 Positive_regulation of ENG 1 0.03 0.39 0.09
188 INT125089 Binding of HLA-B and TDGF1 1 0.24 0.18 0.09
189 INT158012 Binding of ENG and FLT1 1 0.21 0.39 0.09
190 INT214168 Msx1 Positive_regulation of Gene_expression of DST 1 0.00 0.13 0.09
191 INT32290 ENG Regulation of Positive_regulation of Trh 1 0.01 0 0.09
192 INT129624 Bmp7 Positive_regulation of Gene_expression of Id2 1 0.26 0.31 0.08
193 INT129623 Bmp7 Positive_regulation of Gene_expression of Id3 1 0.37 0.31 0.08
194 INT129625 Id2 Positive_regulation of Gene_expression of Bmp7 1 0.24 0.31 0.08
195 INT222511 Il1a Positive_regulation of Gene_expression of Fst 1 0.01 0.32 0.08
196 INT134837 TGFB1 Regulation of SMAD7 1 0.34 0.68 0.08
197 INT129622 Id3 Positive_regulation of Gene_expression of Bmp7 1 0.25 0.31 0.08
198 INT288374 Binding of MLANA and Msx1 1 0.09 0 0.08
199 INT208943 Nfkb1 Positive_regulation of Nkx2-5 1 0.11 0.38 0.08
200 INT297968 Positive_regulation of Binding of BMP2 and IL17C 1 0.21 0.26 0.08

Single Events

The table below shows the top 100 pain related interactions that have been reported for BMP signaling pathway. They are ordered first by their pain relevance and then by number of times they were reported in BMP signaling pathway. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT5861 Gene_expression of Egr1 203 0.78 49.35 68.13
2 INT7675 Gene_expression of ENG 146 0.77 45.35 34.6
3 INT5862 Positive_regulation of Egr1 82 0.70 30.4 33.96
4 INT11764 Positive_regulation of ENG 78 0.61 27.65 33.69
5 INT10799 Localization of ENG 63 0.78 18.67 27.28
6 INT6054 Positive_regulation of Gene_expression of Egr1 67 0.70 18.45 25.93
7 INT57874 Gene_expression of Egr1 113 0.78 68.46 24.95
8 INT57878 Positive_regulation of Gene_expression of Egr1 36 0.70 20.42 14.45
9 INT7674 Regulation of ENG 42 0.30 11.41 14.44
10 INT65277 Negative_regulation of Fst 20 0.43 4.61 11.83
11 INT49660 Positive_regulation of EGR1 54 0.69 32.17 9.89
12 INT57876 Positive_regulation of Egr1 46 0.70 25.6 9.41
13 INT73021 Gene_expression of EGR1 43 0.77 24.65 9.18
14 INT7673 Negative_regulation of ENG 31 0.42 7.9 8.61
15 INT70572 Gene_expression of Fst 33 0.78 5.22 8.24
16 INT6055 Transcription of Egr1 47 0.69 3.61 7.68
17 INT60931 Negative_regulation of Fst 15 0.57 5.44 7.21
18 INT6057 Negative_regulation of Gene_expression of Egr1 17 0.57 4.17 7.17
19 INT47707 Negative_regulation of Egr1 9 0.41 0.17 7.03
20 INT73022 Positive_regulation of Gene_expression of EGR1 21 0.69 10.61 6.5
21 INT23375 Binding of ENG 17 0.47 6.02 6.46
22 INT5860 Regulation of Gene_expression of Egr1 20 0.62 3.02 6.38
23 INT86060 Positive_regulation of Fst 13 0.64 3.04 6.33
24 INT250832 Gene_expression of Fgf8 1 0.77 13.36 6.2
25 INT47704 Regulation of Egr1 17 0.60 2.43 5.18
26 INT47706 Negative_regulation of Positive_regulation of Egr1 9 0.41 6.11 5.1
27 INT65276 Gene_expression of Fst 12 0.65 4.99 5.05
28 INT57376 Transcription of EGR1 20 0.69 12.94 4.84
29 INT204449 Gene_expression of T 17 0.32 9.77 4.77
30 INT51944 Positive_regulation of Transcription of Egr1 12 0.49 1.96 4.72
31 INT117936 Regulation of Gene_expression of Egr1 18 0.60 9.37 4.45
32 INT57157 Gene_expression of TDGF1 5 0.75 3.97 4.02
33 INT123502 Binding of Egr1 11 0.35 6.7 3.77
34 INT15844 Positive_regulation of Localization of ENG 7 0.67 4.2 3.47
35 INT141148 Gene_expression of BMP7 24 0.71 14.34 3.44
36 INT100295 Gene_expression of Bmp7 27 0.78 14.34 3.3
37 INT85809 Gene_expression of BMP2 46 0.78 9.91 3.05
38 INT39990 Negative_regulation of BMP6 1 0.59 0 3.05
39 INT96423 Gene_expression of Bmp2 61 0.78 25.07 3.01
40 INT33237 Regulation of Fst 10 0.39 1.3 3
41 INT32222 Negative_regulation of Gene_expression of ENG 9 0.37 2.23 2.89
42 INT132773 Negative_regulation of Acvr2b 3 0.41 1.55 2.87
43 INT22071 Positive_regulation of Gene_expression of ENG 13 0.50 5.44 2.62
44 INT96640 Negative_regulation of Gene_expression of Egr1 13 0.43 7.22 2.48
45 INT98634 Positive_regulation of Positive_regulation of EGR1 9 0.68 3.43 2.47
46 INT32920 Gene_expression of Msx1 19 0.71 4.24 2.42
47 INT74262 Negative_regulation of Egr1 15 0.57 7.51 2.41
48 INT13997 Regulation of Gene_expression of ENG 11 0.36 3.31 2.31
49 INT12133 Regulation of Localization of ENG 3 0.03 0.57 2.24
50 INT163580 Positive_regulation of Fst 4 0.19 2.85 2.17
51 INT15243 Regulation of Egr1 19 0.61 7.6 2.13
52 INT53434 Positive_regulation of T 7 0.07 3.67 2.09
53 INT80599 Regulation of Positive_regulation of Egr1 3 0.28 0.46 2.09
54 INT2844 Positive_regulation of ID1 6 0.70 3.92 2.03
55 INT135744 Positive_regulation of Id1 4 0.49 3.08 2.02
56 INT29035 Negative_regulation of Wnt1 3 0.41 1.47 2
57 INT138316 Regulation of Fst 5 0.44 1.15 1.99
58 INT32135 Positive_regulation of Positive_regulation of ENG 2 0.02 0.98 1.99
59 INT107178 Gene_expression of Smad4 12 0.65 9.85 1.92
60 INT73023 Binding of EGR1 7 0.48 4.23 1.86
61 INT104912 Gene_expression of Acvr2a 8 0.63 4.48 1.81
62 INT57375 Regulation of EGR1 5 0.40 1.94 1.78
63 INT57875 Positive_regulation of Positive_regulation of Egr1 6 0.49 2.74 1.75
64 INT120088 Gene_expression of Bmp4 37 0.73 13.89 1.73
65 INT250841 Positive_regulation of Gene_expression of Fgf8 1 0.69 3.8 1.72
66 INT15845 Negative_regulation of Localization of ENG 3 0.05 0.76 1.71
67 INT280933 Binding of Fst 4 0.12 3.53 1.63
68 INT89865 Gene_expression of Nkx2-5 14 0.75 2.99 1.58
69 INT57877 Negative_regulation of Positive_regulation of Egr1 4 0.42 1.63 1.57
70 INT81982 Gene_expression of Bmpr2 36 0.60 14.58 1.55
71 INT278715 Gene_expression of LEF1 10 0.33 5.43 1.54
72 INT89871 Gene_expression of Gata4 11 0.69 1.05 1.53
73 INT278727 Negative_regulation of Gene_expression of LEF1 3 0.11 1.59 1.47
74 INT53003 Positive_regulation of Positive_regulation of Egr1 6 0.64 2.36 1.44
75 INT130014 Positive_regulation of BMP2 11 0.66 5.34 1.42
76 INT98635 Negative_regulation of Gene_expression of EGR1 5 0.58 2.2 1.42
77 INT165538 Binding of Bmp7 5 0.37 1.87 1.39
78 INT287241 Positive_regulation of BMP7 10 0.43 2.68 1.38
79 INT141344 Transcription of Egr1 11 0.70 5.59 1.34
80 INT26658 Localization of ID1 1 0.32 0.18 1.33
81 INT250850 Negative_regulation of Gene_expression of Fgf8 1 0.42 2.79 1.33
82 INT152951 Negative_regulation of LEF1 5 0.41 3.22 1.31
83 INT70619 Regulation of Bmp2 6 0.60 3.1 1.29
84 INT52212 Gene_expression of Bmp6 6 0.64 2.38 1.27
85 INT32717 Negative_regulation of Regulation of ENG 3 0.00 0.43 1.25
86 INT39991 Negative_regulation of Negative_regulation of BMP6 1 0.43 0 1.24
87 INT333924 Positive_regulation of TDGF1 1 0.02 1.03 1.24
88 INT138726 Positive_regulation of Gene_expression of Msx1 5 0.53 1.73 1.2
89 INT226407 Negative_regulation of T 2 0.21 1.81 1.18
90 INT333920 Negative_regulation of Gene_expression of TDGF1 1 0.02 0.89 1.16
91 INT51863 Negative_regulation of Negative_regulation of ENG 2 0.04 0.51 1.13
92 INT96424 Transcription of Bmp2 6 0.69 6.34 1.11
93 INT98633 Negative_regulation of Transcription of EGR1 3 0.43 0.79 1.11
94 INT250840 Negative_regulation of Fgf8 1 0.43 1.92 1.11
95 INT208427 Regulation of T 3 0.25 3.28 1.08
96 INT160538 Binding of Bmp2 4 0.40 2.08 1.07
97 INT277461 Positive_regulation of Gene_expression of Fgf8 1 0.24 0.47 1.05
98 INT123503 Positive_regulation of Binding of Egr1 3 0.13 2.34 1.04
99 INT161716 Localization of Nkx2-5 2 0.74 2.17 1.02
100 INT109075 Positive_regulation of Transcription of NKX2-5 1 0.67 0 1.02
101 INT109069 Transcription of Gata4 4 0.64 0.52 1.01
102 INT109070 Positive_regulation of Transcription of Gata4 1 0.03 0 1.01
103 INT109074 Transcription of NKX2-5 1 0.69 0 1.01
104 INT123501 Negative_regulation of Binding of Egr1 2 0.12 2.04 0.99
105 INT51947 Regulation of Transcription of Egr1 2 0.59 0.15 0.96
106 INT333922 Negative_regulation of TDGF1 1 0.02 0.91 0.96
107 INT52213 Regulation of Localization of Bmp6 1 0.44 0.39 0.93
108 INT114664 Binding of BMP2 12 0.37 6.54 0.91
109 INT98638 Positive_regulation of Transcription of EGR1 3 0.49 2.83 0.91
110 INT280942 Localization of Fst 2 0.22 2.13 0.91
111 INT52215 Localization of Bmp6 1 0.73 0.37 0.88
112 INT142122 Regulation of Gene_expression of Bmp4 5 0.43 2.69 0.86
113 INT287093 Positive_regulation of Gene_expression of T 1 0.28 1.47 0.86
114 INT287090 Regulation of Gene_expression of T 1 0.18 2.77 0.86
115 INT202628 Gene_expression of Wnt1 20 0.67 9.2 0.82
116 INT109062 Gene_expression of NKX2-5 7 0.75 3.31 0.82
117 INT278710 Phosphorylation of LEF1 1 0.05 0.76 0.82
118 INT210247 Positive_regulation of Bmp4 6 0.65 4.36 0.8
119 INT287094 Transcription of T 1 0.29 1.41 0.8
120 INT9206 Negative_regulation of ID1 5 0.59 2.41 0.79
121 INT141150 Localization of BMP7 4 0.56 2.84 0.76
122 INT98636 Negative_regulation of Positive_regulation of EGR1 3 0.58 2.21 0.73
123 INT95617 Regulation of Msx1 2 0.56 1.05 0.73
124 INT114604 Positive_regulation of Acvr2a 2 0.41 0 0.73
125 INT172960 Negative_regulation of Gene_expression of Smad4 7 0.39 5.88 0.71
126 INT6050 Localization of Egr1 4 0.68 0.53 0.7
127 INT226411 Binding of T 2 0.15 1.56 0.68
128 INT141341 Binding of Egr1 5 0.48 2.65 0.67
129 INT156967 Localization of Fst 2 0.66 0.1 0.66
130 INT75043 Binding of Msx1 6 0.35 2.36 0.65
131 INT89870 Localization of Myh6 1 0.26 0 0.65
132 INT102686 Phosphorylation of Egr1 3 0.59 2.57 0.64
133 INT11763 Positive_regulation of Regulation of ENG 1 0.01 0.97 0.64
134 INT156968 Negative_regulation of Localization of Fst 1 0.37 0.1 0.64
135 INT96422 Gene_expression of Bmp4 18 0.69 3.26 0.63
136 INT89861 Negative_regulation of Nkx2-5 3 0.19 0.12 0.63
137 INT39994 Positive_regulation of BMP6 1 0.50 0 0.63
138 INT39992 Positive_regulation of Negative_regulation of BMP6 1 0.47 0 0.62
139 INT100294 Positive_regulation of Gene_expression of Bmp7 8 0.46 5.41 0.61
140 INT89867 Negative_regulation of Gene_expression of Gata4 3 0.38 0.17 0.61
141 INT39993 Regulation of BMP6 2 0.39 0.29 0.6
142 INT238049 Positive_regulation of Gene_expression of BMP2 8 0.51 2.06 0.59
143 INT89126 Regulation of BMP7 7 0.45 2.5 0.58
144 INT32921 Positive_regulation of Msx1 4 0.47 0.99 0.57
145 INT89868 Negative_regulation of Gata4 1 0.38 0 0.57
146 INT89869 Negative_regulation of Gene_expression of Nkx2-5 1 0.41 0 0.56
147 INT73020 Positive_regulation of Binding of EGR1 1 0.49 0.46 0.56
148 INT103781 Negative_regulation of Smad4 9 0.42 4.42 0.54
149 INT98632 Negative_regulation of EGR1 6 0.42 3.38 0.54
150 INT110924 Regulation of BMPR2 3 0.17 1.75 0.54
151 INT2845 Gene_expression of ID1 6 0.78 3.97 0.53
152 INT349703 Positive_regulation of Transcription of Fst 1 0.46 0.14 0.53
153 INT81061 Regulation of Negative_regulation of Egr1 1 0.22 0 0.53
154 INT349725 Transcription of Fst 1 0.63 0.13 0.53
155 INT165537 Negative_regulation of Bmp7 2 0.43 0.55 0.52
156 INT85808 Localization of BMP2 7 0.77 1.94 0.51
157 INT159214 Positive_regulation of Gene_expression of BMP7 6 0.46 2.16 0.51
158 INT135749 Gene_expression of Id1 3 0.58 0.57 0.49
159 INT305390 Negative_regulation of NKX2-5 2 0.37 2.24 0.49
160 INT168801 Localization of Egr1 4 0.78 0.7 0.48
161 INT250845 Protein_catabolism of Fgf8 1 0.98 1.64 0.48
162 INT145301 Regulation of Gene_expression of Bmp2 1 0.32 1.16 0.48
163 INT268007 Gene_expression of Fgf8 8 0.72 1.38 0.47
164 INT129620 Regulation of Gene_expression of Bmp7 3 0.42 3.2 0.47
165 INT52214 Regulation of Gene_expression of Bmp6 1 0.37 0.19 0.46
166 INT141342 Negative_regulation of Transcription of Egr1 4 0.43 2.39 0.45
167 INT142124 Binding of Bmp4 1 0.35 0.46 0.45
168 INT218293 Gene_expression of Acvr2b 14 0.76 4.22 0.44
169 INT192006 Gene_expression of RYR2 5 0.23 7.69 0.44
170 INT71019 Negative_regulation of SMAD4 12 0.42 6.88 0.43
171 INT120086 Gene_expression of Bmp2 5 0.27 2.34 0.43
172 INT277465 Regulation of Gene_expression of Fgf8 2 0.25 0.43 0.43
173 INT247307 Negative_regulation of Msx1 3 0.22 0.11 0.42
174 INT285501 Gene_expression of Smad1 6 0.42 3.09 0.41
175 INT180688 Transcription of Bmp4 3 0.58 0.35 0.41
176 INT180702 Positive_regulation of Transcription of Bmp4 3 0.42 0.35 0.41
177 INT287095 Negative_regulation of Gene_expression of T 1 0.24 0.47 0.41
178 INT243756 Regulation of Positive_regulation of Egr1 7 0.45 1.18 0.4
179 INT118460 Binding of Bmp7 3 0.46 1.3 0.4
180 INT311882 Negative_regulation of Smad1 1 0.25 0.99 0.39
181 INT123185 Positive_regulation of Gene_expression of Bmp6 2 0.24 1.28 0.38
182 INT117564 Gene_expression of SMAD4 12 0.71 8.7 0.37
183 INT84945 Transcription of BMP2 5 0.61 1.8 0.36
184 INT317694 Negative_regulation of Localization of Fst 1 0.12 0.79 0.36
185 INT196026 Positive_regulation of Gene_expression of Bmp2 14 0.69 3.19 0.35
186 INT144968 Positive_regulation of Localization of EGR1 1 0.69 0.82 0.35
187 INT150330 Gene_expression of BMPR2 7 0.29 4.22 0.34
188 INT251324 Binding of Bmpr2 5 0.23 2.99 0.34
189 INT201967 Positive_regulation of Bmpr2 4 0.31 1.24 0.34
190 INT288541 Negative_regulation of Gene_expression of Fst 2 0.23 1.18 0.34
191 INT250826 Transcription of Fgf8 1 0.71 0.71 0.34
192 INT144970 Localization of EGR1 1 0.80 0.82 0.34
193 INT111230 Transcription of LEF1 3 0.30 1.72 0.33
194 INT109058 Positive_regulation of Gene_expression of Gata4 2 0.29 0 0.33
195 INT209302 Gene_expression of Scx 1 0.20 0.05 0.33
196 INT188498 Negative_regulation of Transcription of Egr1 3 0.41 0.14 0.32
197 INT349714 Binding of Fst 1 0.34 0.19 0.32
198 INT196032 Positive_regulation of Gene_expression of Bmp7 10 0.17 1.31 0.31
199 INT134840 Gene_expression of SMAD7 1 0.74 2.74 0.31
200 INT196024 Gene_expression of Bmp7 20 0.26 1.88 0.3
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