GO:0030517

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Name negative regulation of axon extension
Categary Process
Go Slim No
Go Link GO:0030517
Unique Molecular Interactions 173
Total Molecular Interactions 223
Total Single Events 1149
Pain Genes Associated 10

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for negative regulation of axon extension. They are ordered first by their pain relevance and then by number of times they were reported for negative regulation of axon extension. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT181455 Binding of Ccr5 and Ccl5 11 0.39 12.13 3.66
2 INT334532 Sema3a Negative_regulation of Gene_expression of Nrp1 1 0.19 7.58 2
3 INT181450 Binding of Ccr5 and Ccl3 4 0.18 2.19 1.03
4 INT137441 Ngf Negative_regulation of Sema3a 1 0.46 2.07 1.01
5 INT334537 Sema3a Negative_regulation of Gene_expression of Plxna1 1 0.08 3.76 1
6 INT275406 Binding of ITIH4 and Ccr5 1 0.09 2.88 0.97
7 INT275390 Binding of Ccr5 and Htatsf1 1 0.01 3.26 0.97
8 INT149559 Tgfb1 Positive_regulation of Gene_expression of Ccr5 1 0.00 0 0.88
9 INT149560 Tgfb1 Positive_regulation of Ccr5 1 0.00 0 0.88
10 INT222243 Negative_regulation of Binding of Trpv1 and Ccr5 1 0.21 0.57 0.86
11 INT222244 Binding of Trpv1 and Ccr5 1 0.19 0.57 0.86
12 INT123494 Binding of Egr1 and Ccr5 1 0.04 0.94 0.71
13 INT260832 Binding of NRP2 and Nrp1 1 0.00 2.32 0.7
14 INT188471 Binding of Gpi1 and Arhgap4 1 0.07 1.61 0.58
15 INT244232 Binding of Ccr5 and Ccl4 3 0.17 1.48 0.55
16 INT334526 Trpv1 Positive_regulation of Gene_expression of Sema3a 1 0.31 0.92 0.55
17 INT155254 Col4a4 Regulation of Rtn4 1 0.00 0 0.54
18 INT125086 LPA Positive_regulation of Rtn4 1 0.00 0.36 0.54
19 INT275387 Binding of Lamp1 and Ccr5 1 0.01 1.45 0.52
20 INT275405 Binding of GOLPH3 and Ccr5 1 0.00 1.46 0.52
21 INT275407 Binding of ERVW-1 and Ccr5 1 0.00 1.74 0.46
22 INT123511 TIAF1 Positive_regulation of Gene_expression of Ccr5 1 0.00 0.6 0.37
23 INT123495 Negative_regulation of Binding of Egr1 and Ccr5 1 0.03 0.48 0.36
24 INT123493 Regulation of Binding of Egr1 and Ccr5 1 0.03 0.48 0.36
25 INT137438 Ntf3 Regulation of Sema3a 1 0.06 0.82 0.35
26 INT137437 Nrtn Regulation of Sema3a 1 0.36 0.82 0.35
27 INT137439 Ntf3 Negative_regulation of Sema3a 1 0.02 0.77 0.34
28 INT137442 Nrtn Regulation of Sema3a 1 0.04 0.81 0.34
29 INT137440 Nrtn Negative_regulation of Sema3a 1 0.34 0.77 0.34
30 INT189494 Negative_regulation of Ccr5 Negative_regulation of Gene_expression of Hand1 1 0.16 0.66 0.32
31 INT284229 Binding of ITIH4 and Ccr5 1 0.10 0.27 0.31
32 INT69362 Binding of Pnoc and Rtn4 1 0.01 0 0.31
33 INT295354 Ntn1 Positive_regulation of Grb7 1 0.04 0.51 0.29
34 INT295360 Ntn1 Positive_regulation of Ptk2 1 0.09 0.51 0.29
35 INT141545 Binding of Bace1 and Rtn4 1 0.00 0.45 0.27
36 INT141550 Binding of Rtn4r and Rtn4 1 0.00 0.46 0.26
37 INT275553 Negative_regulation of Binding of Ccr5 and Ccl3 1 0.05 0.73 0.26
38 INT181445 Binding of Ccr5 and Hand1 1 0.12 1.01 0.22
39 INT334522 Ngf Positive_regulation of Nrp1 1 0.19 0.93 0.22
40 INT155158 Agtr2 Regulation of Rtn4 1 0.00 0.1 0.22
41 INT334525 Ngf Positive_regulation of Gene_expression of Nrp1 1 0.19 0.93 0.22
42 INT244093 Binding of C2 and Arhgap4 3 0.23 0.38 0.19
43 INT244240 Binding of IL8 and Ccr5 1 0.03 0.05 0.18
44 INT213561 Ngf Negative_regulation of Regulation of Sema3a 1 0.24 0.08 0.17
45 INT284230 Positive_regulation of Binding of ITIH4 and Ccr5 1 0.10 0 0.17
46 INT334531 Nrp1 Negative_regulation of Gene_expression of Il4 1 0.08 0.48 0.14
47 INT284226 Negative_regulation of Binding of Ccr5 and Hivan1 1 0.01 0.27 0.14
48 INT213555 Bdnf Negative_regulation of Gene_expression of Sema3a 1 0.31 0.09 0.14
49 INT284217 Binding of Ccr5 and Hivan1 1 0.01 0.27 0.14
50 INT334527 Sema3a Negative_regulation of Gene_expression of Il4 1 0.15 0.48 0.14
51 INT352417 Ccl2 Positive_regulation of Ccr5 1 0.06 0.26 0.14
52 INT334534 Nrp1 Negative_regulation of Gene_expression of Sema3a 1 0.17 0.48 0.14
53 INT333652 Binding of Ccr5 and Msc 1 0.10 0.07 0.13
54 INT334530 Sema3a Regulation of Il18 1 0.18 1.61 0.13
55 INT334528 Nrp1 Negative_regulation of Sema3a 1 0.17 0.47 0.13
56 INT334524 Sema3a Regulation of Foxq1 1 0.04 1.61 0.13
57 INT284219 Binding of Ccr5 and Avpr1b 1 0.01 0.46 0.12
58 INT284208 Binding of Ccr5 and Eclc 1 0.08 0.3 0.12
59 INT221628 Sema3a Regulation of Gh 1 0.01 0.39 0.12
60 INT221625 Fer Regulation of Localization of Sema3a 1 0.24 0.29 0.1
61 INT284220 Binding of Ccr5 and Mela 1 0.12 0.23 0.1
62 INT221668 Sema3a Positive_regulation of NPAT 1 0.36 0.47 0.09
63 INT221614 Binding of Sema3a and Fer 1 0.30 0.61 0.09
64 INT284222 Binding of Ccr5 and Musd1 1 0.01 0.5 0.07
65 INT284216 Binding of Ccr5 and Arhgap4 1 0.02 0.31 0.07
66 INT221619 Binding of Ngf and Sema3a 1 0.17 0.54 0.06
67 INT221658 Sema3a Positive_regulation of Phosphorylation of Crmp1 1 0.12 0.4 0.05
68 INT221657 Sema3a Positive_regulation of Binding of Plxna1 1 0.01 0.39 0.05
69 INT284209 Negative_regulation of Binding of Ccr5 and Mela 1 0.14 0.12 0.05
70 INT284225 Binding of Cd4 and Ccr5 1 0.30 0.26 0.04
71 INT221661 Sema3a Positive_regulation of Phosphorylation of Cdk5 1 0.19 0.28 0.03
72 INT221640 Sema3a Positive_regulation of Phosphorylation of Fyn 1 0.16 0.29 0.03
73 INT221626 Gopc Regulation of Sema3a 1 0.06 0.13 0.03
74 INT203418 Enc1 Negative_regulation of Rtn4 1 0.08 0.58 0
75 INT221644 Binding of Nptx1 and Sema3a 1 0.12 0.19 0
76 INT290908 Regulation of Shh Positive_regulation of Ntn1 1 0.12 0 0
77 INT203406 Cap2 Negative_regulation of Rtn4 1 0.07 0.59 0
78 INT203410 Vsnl1 Negative_regulation of Rtn4 1 0.18 0.58 0
79 INT290909 Negative_regulation of Binding of Nos2 and Ntn1 1 0.12 0 0
80 INT290903 Binding of Nos2 and Ntn1 1 0.10 0 0
81 INT279508 Binding of Arhgap4 and Positive_regulation of C1s 1 0.01 0.33 0
82 INT351678 Nrp1 Regulation of Binding of Ecm1 1 0.00 1.55 0
83 INT203396 Mllt11 Negative_regulation of Rtn4 1 0.09 0.58 0
84 INT203399 Olfm1 Negative_regulation of Rtn4 1 0.09 0.58 0
85 INT342038 Binding of Gdnf and Ntn1 1 0.01 0.78 0
86 INT196185 Binding of SEMA3A and Nrp1 1 0.01 0.05 0
87 INT290907 Shh Positive_regulation of Ntn1 1 0.32 0.05 0
88 INT221638 Binding of Nrp1 and Sema3a 1 0.05 0.38 0
89 INT290902 Prkcg Regulation of Positive_regulation of Ntn1 1 0.10 0 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for negative regulation of axon extension. They are ordered first by their pain relevance and then by number of times they were reported in negative regulation of axon extension. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT5923 Negative_regulation of Rtn4 50 0.36 24.19 27.2
2 INT56239 Positive_regulation of Rtn4 20 0.26 14.05 18.8
3 INT167679 Gene_expression of Ccr5 74 0.75 59.03 18.16
4 INT5922 Gene_expression of Rtn4 27 0.48 12.7 17.86
5 INT53070 Regulation of Rtn4 15 0.22 9.35 13.77
6 INT87393 Gene_expression of Ccr5 19 0.65 11 10.51
7 INT153268 Positive_regulation of Ccr5 25 0.66 19 7.02
8 INT132026 Gene_expression of Ntn1 7 0.78 5.97 6.01
9 INT120089 Negative_regulation of Ccr5 7 0.58 10.36 5.91
10 INT103847 Positive_regulation of Ccr5 11 0.55 6.04 5.79
11 INT181406 Binding of Ccr5 16 0.45 17 5.78
12 INT75546 Transcription of Rtn4 1 0.06 2.87 5.03
13 INT153189 Gene_expression of Sema3a 19 0.75 14.37 4.21
14 INT103843 Positive_regulation of Gene_expression of Ccr5 5 0.42 2.31 3.89
15 INT52184 Gene_expression of Sema3a 8 0.55 3.97 3.72
16 INT184390 Binding of Arhgap4 13 0.36 3.29 3.35
17 INT156676 Gene_expression of Rtn4 14 0.65 5.78 3.16
18 INT166879 Localization of Ccr5 4 0.71 3.62 2.97
19 INT87395 Binding of Ccr5 5 0.29 2.5 2.6
20 INT129742 Regulation of Positive_regulation of Rtn4 2 0.05 2.51 2.33
21 INT181356 Positive_regulation of Gene_expression of Ccr5 11 0.66 8.3 2.24
22 INT240113 Gene_expression of Nrp1 11 0.30 10.88 2.24
23 INT96743 Transcription of Ccr5 2 0.54 2.72 2.17
24 INT184391 Gene_expression of Arhgap4 9 0.75 4.83 2.07
25 INT153190 Negative_regulation of Sema3a 7 0.56 7.94 1.76
26 INT87394 Negative_regulation of Ccr5 3 0.32 1.3 1.74
27 INT132030 Positive_regulation of Gene_expression of Ntn1 2 0.70 1.89 1.69
28 INT153762 Positive_regulation of Gene_expression of Sema3a 6 0.49 4.56 1.65
29 INT132027 Positive_regulation of Ntn1 3 0.50 2.24 1.63
30 INT72647 Positive_regulation of Gene_expression of Sema3a 3 0.40 1.98 1.52
31 INT235907 Regulation of Negative_regulation of Rtn4 1 0.07 2.93 1.42
32 INT5920 Binding of Rtn4 6 0.36 0.66 1.21
33 INT163963 Negative_regulation of Transcription of Rtn4 1 0.03 0.45 1.06
34 INT196095 Localization of Arhgap4 4 0.73 0.31 0.95
35 INT87396 Negative_regulation of Gene_expression of Ccr5 1 0.12 1.02 0.92
36 INT132025 Positive_regulation of Regulation of Ntn1 1 0.47 0.82 0.9
37 INT132029 Regulation of Ntn1 1 0.27 0.82 0.89
38 INT189482 Regulation of Gene_expression of Ccr5 4 0.44 3.38 0.86
39 INT104333 Negative_regulation of Positive_regulation of Rtn4 1 0.03 0.42 0.84
40 INT160410 Positive_regulation of Positive_regulation of Ccr5 2 0.38 1.31 0.83
41 INT220888 Negative_regulation of Arhgap4 5 0.42 2.19 0.78
42 INT264311 Positive_regulation of Transcription of Arhgap4 1 0.49 1.53 0.78
43 INT264312 Transcription of Arhgap4 1 0.67 1.53 0.77
44 INT132028 Negative_regulation of Gene_expression of Ntn1 1 0.59 0.71 0.75
45 INT104457 Negative_regulation of Gene_expression of Rtn4 1 0.01 0.64 0.71
46 INT3536 Positive_regulation of Nrp1 2 0.19 0.93 0.7
47 INT196155 Binding of Nrp1 5 0.16 2.38 0.69
48 INT132023 Negative_regulation of Ntn1 2 0.43 0.64 0.66
49 INT115892 Positive_regulation of Phosphorylation of Ccr5 1 0.00 0 0.66
50 INT132024 Positive_regulation of Negative_regulation of Ntn1 1 0.50 0.64 0.66
51 INT260823 Positive_regulation of Gene_expression of Nrp1 3 0.19 2.14 0.65
52 INT115896 Phosphorylation of Ccr5 1 0.01 0 0.65
53 INT116175 Negative_regulation of Gene_expression of Sema3a 1 0.30 0.67 0.63
54 INT181364 Regulation of Ccr5 3 0.32 1.81 0.62
55 INT89067 Regulation of Gene_expression of Sema3a 2 0.31 0.84 0.61
56 INT134304 Positive_regulation of Sema3a 1 0.50 1.23 0.59
57 INT72648 Localization of Sema3a 1 0.28 0.38 0.58
58 INT158486 Negative_regulation of Gene_expression of Sema3a 4 0.41 2.49 0.57
59 INT72646 Binding of Sema3a 2 0.15 0.52 0.54
60 INT221545 Binding of Sema3a 2 0.33 1.4 0.53
61 INT103844 Regulation of Gene_expression of Ccr5 1 0.22 0.55 0.51
62 INT181376 Negative_regulation of Gene_expression of Ccr5 3 0.41 2.12 0.49
63 INT79935 Negative_regulation of Nrp1 3 0.17 1.36 0.46
64 INT135986 Negative_regulation of Sema3a 3 0.58 0.3 0.46
65 INT181397 Transcription of Ccr5 2 0.62 1.33 0.46
66 INT87392 Regulation of Ccr5 1 0.17 0.53 0.46
67 INT135987 Regulation of Sema3a 2 0.60 0.57 0.43
68 INT213530 Regulation of Sema3a 3 0.29 0.84 0.42
69 INT5921 Positive_regulation of Gene_expression of Rtn4 1 0.26 0.35 0.42
70 INT222240 Positive_regulation of Transcription of Ccr5 1 0.37 0.7 0.4
71 INT294813 Positive_regulation of Positive_regulation of Arhgap4 1 0.43 0.28 0.39
72 INT322707 Protein_catabolism of Ccr5 1 0.22 0.32 0.37
73 INT207306 Positive_regulation of Arhgap4 1 0.43 0.27 0.36
74 INT213538 Localization of Sema3a 2 0.56 1.12 0.32
75 INT221527 Positive_regulation of Sema3a 1 0.37 1.03 0.32
76 INT221579 Phosphorylation of Sema3a 1 0.46 0.82 0.3
77 INT235908 Localization of Rtn4 1 0.08 0.25 0.23
78 INT226977 Positive_regulation of Gene_expression of Rtn4 1 0.51 1.1 0.19
79 INT284203 Positive_regulation of Negative_regulation of Ccr5 1 0.41 0.41 0.18
80 INT297294 Negative_regulation of Ntn1 1 0.17 0.72 0.16
81 INT311984 Positive_regulation of Gene_expression of Arhgap4 1 0.49 0.86 0.16
82 INT311982 Negative_regulation of Gene_expression of Arhgap4 1 0.57 0.86 0.16
83 INT216038 Binding of Rtn4 1 0.40 0.8 0.13
84 INT284206 Negative_regulation of Negative_regulation of Ccr5 1 0.40 0 0.12
85 INT89068 Transcription of Sema3a 1 0.14 0.27 0.11
86 INT244078 Negative_regulation of Localization of Arhgap4 1 0.13 0 0.11
87 INT221552 Positive_regulation of Localization of Sema3a 1 0.32 0.29 0.1
88 INT322703 Negative_regulation of Binding of Ccr5 1 0.32 0.41 0.09
89 INT216029 Positive_regulation of Binding of Rtn4 1 0.38 0.33 0.06
90 INT207305 Positive_regulation of Protein_catabolism of Arhgap4 1 0.11 0.6 0.05
91 INT207307 Protein_catabolism of Arhgap4 1 0.20 0.6 0.05
92 INT284205 Phosphorylation of Ccr5 1 0.59 0.08 0.04
93 INT216031 Positive_regulation of Rtn4 1 0.57 0.79 0.03
94 INT290933 Positive_regulation of Positive_regulation of Ntn1 1 0.21 0.45 0.03
95 INT290914 Negative_regulation of Positive_regulation of Ntn1 1 0.18 0.09 0
96 INT279447 Negative_regulation of Binding of Arhgap4 1 0.02 0 0
97 INT302041 Negative_regulation of Gene_expression of Nrp1 1 0.07 0.14 0
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