GO:0030539

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Name male genitalia development
Categary Process
Go Slim No
Go Link GO:0030539
Unique Molecular Interactions 110
Total Molecular Interactions 149
Total Single Events 1008
Pain Genes Associated 19

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for male genitalia development. They are ordered first by their pain relevance and then by number of times they were reported for male genitalia development. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT250867 Fgf8 Positive_regulation of Protein_catabolism of Ecm1 1 0.06 4.35 2.14
2 INT154236 Binding of TBX3 and Ugt2b7 1 0.41 0.74 1
3 INT250868 Fgf8 Positive_regulation of Gene_expression of Mmp3 1 0.15 1.73 0.93
4 INT250861 Fgf8 Positive_regulation of Gene_expression of Ptger2 1 0.04 1.51 0.84
5 INT14178 DHCR24 Positive_regulation of Localization of PDYN 1 0.05 0 0.72
6 INT14177 DHCR24 Positive_regulation of PDYN 1 0.05 0 0.71
7 INT250852 Fgf8 Negative_regulation of Gene_expression of Ecm1 1 0.04 1.1 0.54
8 INT49358 Binding of DHCR24 and Pdyn 1 0.00 0 0.53
9 INT250870 Fgf8 Positive_regulation of Ecm1 1 0.04 0.79 0.38
10 INT300609 Binding of Ctnnb1 and Wnt2 1 0.02 0.25 0.37
11 INT124378 Prodh2 Positive_regulation of Ctnnb1 1 0.00 0.59 0.35
12 INT250856 Fgf8 Positive_regulation of Localization of Mmp3 1 0.11 0.51 0.3
13 INT250864 Fgf8 Positive_regulation of Positive_regulation of Ptger2 1 0.03 0.55 0.28
14 INT250854 Fgf8 Positive_regulation of Positive_regulation of Mmp3 1 0.11 0.55 0.28
15 INT250873 Fgf8 Positive_regulation of GAG 1 0.55 0.48 0.23
16 INT256629 Binding of Ptch1 and Shh 7 0.42 4.22 0.19
17 INT135463 Binding of DHCR24 and Fos 1 0.35 0.17 0.19
18 INT135462 Binding of DHCR24 and Cfp 1 0.00 0.17 0.18
19 INT198382 Binding of AR and SRD5A1 2 0.06 0.84 0.17
20 INT350713 MIR219-1 Negative_regulation of Pdgfra 1 0.00 0.4 0.15
21 INT123180 Bmp6 Positive_regulation of Lamtor1 1 0.01 0.61 0.14
22 INT123192 Bmp6 Positive_regulation of CDKN1A 1 0.18 0.61 0.14
23 INT123194 Bmp6 Positive_regulation of TAF9 1 0.18 0.61 0.14
24 INT250863 Fgf8 Positive_regulation of Ptger2 1 0.03 0.19 0.14
25 INT123193 Bmp6 Positive_regulation of Negative_regulation of TAF9 1 0.18 0.61 0.14
26 INT251115 Positive_regulation of Binding of AR and Ctnnb1 1 0.01 1.02 0.13
27 INT251114 Binding of AR and Ctnnb1 1 0.01 1 0.12
28 INT250866 Binding of Fgfr4 and Fgf8 1 0.12 0.35 0.11
29 INT158141 Binding of HOXD13 and SNCA 1 0.54 0.41 0.11
30 INT250860 Fgf8 Regulation of Localization of Ptger2 1 0.02 0.13 0.1
31 INT250862 Fgf8 Regulation of Localization of Mmp3 1 0.13 0.13 0.1
32 INT250859 Fgf8 Negative_regulation of Gene_expression of Mmp3 1 0.09 0.12 0.09
33 INT250872 Fgf8 Positive_regulation of Mmp3 1 0.11 0.12 0.09
34 INT270464 Binding of Shh and Smo 1 0.07 1.3 0.08
35 INT290906 Shh Positive_regulation of Egfr 1 0.23 0 0.08
36 INT201173 Sox2 Positive_regulation of Localization of Ryr2 1 0.40 0.9 0.07
37 INT298349 HES3 Positive_regulation of Shh 1 0.12 0.14 0.07
38 INT201172 Sox2 Positive_regulation of Localization of Ca2 1 0.47 0.9 0.07
39 INT168976 Binding of Wt1 and Calb2 1 0.01 1.39 0.07
40 INT290905 Gene_expression of Shh Positive_regulation of Gene_expression of Angpt1 1 0.14 0 0.06
41 INT250865 Binding of Fgf8 and Fgfr3 1 0.18 0.3 0.05
42 INT213562 Ctnnd2 Regulation of Gene_expression of Sox2 1 0.35 0.07 0.05
43 INT181601 Binding of TP53 and WT1 1 0.30 0.9 0.05
44 INT250855 Binding of Fgfr2 and Fgf8 1 0.12 0.3 0.05
45 INT263431 Trib3 Regulation of Pdgfra 1 0.00 0 0.04
46 INT213563 Binding of Ctnnd2 and Shh 1 0.27 0.09 0.04
47 INT270459 Binding of Shh and Gli1 1 0.02 0.65 0.04
48 INT263428 Abl1 Regulation of Pdgfra 1 0.00 0 0.04
49 INT276583 Binding of Wt1 and IgG 1 0.07 0 0.04
50 INT352014 Shh Positive_regulation of Gene_expression of Pax1 1 0.29 0.07 0.03
51 INT311655 Shh Positive_regulation of Gene_expression of Fgf8 1 0.31 0.18 0.03
52 INT270462 Shh Positive_regulation of Ccnd1 1 0.10 0.6 0.03
53 INT213559 Binding of Egf and Shh 1 0.17 0.07 0.03
54 INT205409 Binding of BMP6 and BMPR2 1 0.07 0.05 0
55 INT290910 Pkm2 Negative_regulation of Shh 1 0.07 0.06 0
56 INT276586 Binding of Wt1 and Actn1 1 0.34 0.41 0
57 INT205963 GLI1 Positive_regulation of Negative_regulation of SHH 1 0.22 0.58 0
58 INT355603 Binding of CTNNA1 and Ctnnb1 1 0.00 1.07 0
59 INT314850 Shh Regulation of Atoh7 1 0.45 0.22 0
60 INT314692 Binding of TBX2 and TBX3 1 0.27 0.84 0
61 INT220818 Binding of Ctnnb1 and Myc 1 0.06 0.13 0
62 INT205452 Binding of BMP6 and Acvr2a 1 0.03 0.05 0
63 INT290908 Regulation of Shh Positive_regulation of Ntn1 1 0.12 0 0
64 INT209159 Binding of LHCGR and PDE5A 1 0.01 0 0
65 INT286566 Binding of Ctnnb1 and Cdh6 1 0.00 1 0
66 INT290911 Gene_expression of Shh Positive_regulation of Pkm2 1 0.07 0 0
67 INT286562 Gene_expression of Pkd1 Positive_regulation of Ctnnb1 1 0.02 0.52 0
68 INT290904 Shh Positive_regulation of Prkcg 1 0.26 0.06 0
69 INT290900 Prkcg Regulation of Shh 1 0.23 0 0
70 INT188836 Binding of LHCGR and C4b 1 0.39 0.76 0
71 INT136693 Gtf3a Positive_regulation of Ctnnb1 1 0.05 0 0
72 INT205960 Binding of PTCH1 and SHH 1 0.21 0.71 0
73 INT290944 Shh Positive_regulation of VEGFA 1 0.04 0.05 0
74 INT270461 Shh Regulation of Gene_expression of Ptch1 1 0.48 0.07 0
75 INT205959 Binding of SHH and SMOX 1 0.12 0.72 0
76 INT220821 Binding of MAX and Ctnnb1 1 0.09 0.13 0
77 INT270471 Shh Regulation of VEGFA 1 0.39 0.08 0
78 INT290898 Shh Positive_regulation of Nos2 1 0.46 0.05 0
79 INT286561 Binding of Ctnnb1 and Cdh2 1 0.00 1.06 0
80 INT286567 Prkd1 Regulation of Ctnnb1 1 0.01 0.39 0
81 INT270466 Ptch1 Regulation of Gene_expression of Shh 1 0.48 0.07 0
82 INT270460 Shh Positive_regulation of Gene_expression of Angpt1 1 0.04 0.08 0
83 INT181599 Binding of EWSR1 and WT1 1 0.40 0.29 0
84 INT270470 Shh Regulation of Gene_expression of VEGFA 1 0.39 0.15 0
85 INT290907 Shh Positive_regulation of Ntn1 1 0.32 0.05 0
86 INT205977 Binding of SHH and Ptch1 1 0.31 0.71 0
87 INT214885 Binding of PDGFRA and Atcay 1 0.08 4.05 0
88 INT270469 Shh Positive_regulation of VEGFA 1 0.29 0.12 0
89 INT276590 Binding of Wt1 and KTWS 1 0.02 0.3 0
90 INT286572 Binding of Ctnnb1 and Pkd1 1 0.02 0.96 0
91 INT270468 Shh Positive_regulation of Gene_expression of VEGFA 1 0.44 0.08 0
92 INT163415 HOXD13 Regulation of Positive_regulation of Nfkb1 1 0.02 0 0
93 INT264737 Hes1 Regulation of Shh 1 0.19 0.13 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for male genitalia development. They are ordered first by their pain relevance and then by number of times they were reported in male genitalia development. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT99495 Gene_expression of SRD5A1 14 0.77 5 9.21
2 INT250832 Gene_expression of Fgf8 1 0.77 13.36 6.2
3 INT99889 Transcription of SRD5A1 5 0.71 1.45 3.74
4 INT39990 Negative_regulation of BMP6 1 0.59 0 3.05
5 INT16616 Negative_regulation of SRD5A1 44 0.57 34.81 2.96
6 INT101567 Gene_expression of Ctnnb1 7 0.64 10.11 2.89
7 INT342815 Positive_regulation of Transcription of SRD5A1 1 0.49 0.33 2.04
8 INT81641 Gene_expression of Ctnnb1 23 0.72 14.93 1.97
9 INT144973 Gene_expression of Shh 9 0.77 4.32 1.96
10 INT208561 Gene_expression of Shh 51 0.78 9.57 1.77
11 INT250841 Positive_regulation of Gene_expression of Fgf8 1 0.69 3.8 1.72
12 INT8911 Regulation of DHCR24 1 0.05 1.91 1.71
13 INT123990 Positive_regulation of Ctnnb1 8 0.43 2.85 1.63
14 INT99391 Localization of Ctnnb1 7 0.80 5.84 1.61
15 INT250850 Negative_regulation of Gene_expression of Fgf8 1 0.42 2.79 1.33
16 INT52212 Gene_expression of Bmp6 6 0.64 2.38 1.27
17 INT198387 Regulation of SRD5A1 2 0.60 1.29 1.26
18 INT39991 Negative_regulation of Negative_regulation of BMP6 1 0.43 0 1.24
19 INT99389 Negative_regulation of Ctnnb1 8 0.45 3.97 1.21
20 INT59029 Positive_regulation of DHCR24 2 0.22 0.51 1.18
21 INT253191 Positive_regulation of Gene_expression of Shh 2 0.66 2.57 1.14
22 INT250840 Negative_regulation of Fgf8 1 0.43 1.92 1.11
23 INT101570 Positive_regulation of Gene_expression of Ctnnb1 1 0.58 5.7 1.07
24 INT165530 Positive_regulation of Shh 4 0.69 1.21 1.05
25 INT277461 Positive_regulation of Gene_expression of Fgf8 1 0.24 0.47 1.05
26 INT154493 Regulation of Gene_expression of SRD5A1 3 0.45 0.58 1.03
27 INT52213 Regulation of Localization of Bmp6 1 0.44 0.39 0.93
28 INT101566 Negative_regulation of Gene_expression of Ctnnb1 1 0.35 2.28 0.88
29 INT52215 Localization of Bmp6 1 0.73 0.37 0.88
30 INT119102 Gene_expression of PDGFRA 13 0.75 11.99 0.81
31 INT4762 Negative_regulation of DHCR24 5 0.45 0.68 0.8
32 INT101209 Gene_expression of Wt1 19 0.72 25.77 0.7
33 INT99390 Regulation of Ctnnb1 4 0.62 3.12 0.64
34 INT39994 Positive_regulation of BMP6 1 0.50 0 0.63
35 INT39992 Positive_regulation of Negative_regulation of BMP6 1 0.47 0 0.62
36 INT185244 Gene_expression of Sox2 27 0.65 4.71 0.61
37 INT39993 Regulation of BMP6 2 0.39 0.29 0.6
38 INT13724 Positive_regulation of WT1 5 0.69 4.99 0.59
39 INT88694 Gene_expression of WT1 17 0.75 21.88 0.56
40 INT76960 Negative_regulation of Ctnnb1 5 0.57 3.46 0.53
41 INT342811 Positive_regulation of Gene_expression of SRD5A1 1 0.45 0.22 0.5
42 INT250845 Protein_catabolism of Fgf8 1 0.98 1.64 0.48
43 INT268007 Gene_expression of Fgf8 8 0.72 1.38 0.47
44 INT81645 Positive_regulation of Gene_expression of Ctnnb1 6 0.63 3.78 0.47
45 INT206484 Localization of Shh 2 0.75 1.14 0.46
46 INT52214 Regulation of Gene_expression of Bmp6 1 0.37 0.19 0.46
47 INT232798 Positive_regulation of Gene_expression of Shh 7 0.70 1.49 0.44
48 INT277465 Regulation of Gene_expression of Fgf8 2 0.25 0.43 0.43
49 INT185255 Positive_regulation of Sox2 3 0.26 1.22 0.42
50 INT76958 Positive_regulation of Ctnnb1 14 0.64 5.48 0.41
51 INT95872 Localization of Ctnnb1 7 0.74 2.75 0.4
52 INT208559 Negative_regulation of Gene_expression of Shh 8 0.43 1.58 0.38
53 INT123185 Positive_regulation of Gene_expression of Bmp6 2 0.24 1.28 0.38
54 INT81644 Regulation of Ctnnb1 5 0.41 3.38 0.37
55 INT81643 Regulation of Gene_expression of Ctnnb1 3 0.57 1.5 0.37
56 INT250826 Transcription of Fgf8 1 0.71 0.71 0.34
57 INT14181 Binding of DHCR24 1 0.04 0 0.34
58 INT108324 Negative_regulation of Gene_expression of Ctnnb1 1 0.06 1.43 0.31
59 INT156411 Gene_expression of Pdgfra 8 0.75 5.5 0.3
60 INT102992 Regulation of Negative_regulation of SRD5A1 4 0.60 3.59 0.29
61 INT201143 Regulation of Sox2 6 0.44 2.71 0.26
62 INT232795 Positive_regulation of Shh 2 0.70 3.68 0.26
63 INT164226 Regulation of TBX3 1 0.23 0.57 0.26
64 INT156410 Positive_regulation of Pdgfra 3 0.08 1.51 0.25
65 INT114703 Positive_regulation of Wt1 5 0.46 4.25 0.24
66 INT250836 Binding of Fgf8 3 0.35 0.66 0.24
67 INT151719 Negative_regulation of Positive_regulation of Ctnnb1 1 0.23 1.9 0.24
68 INT126794 Binding of SRD5A1 2 0.36 3.26 0.22
69 INT183062 Gene_expression of SHH 12 0.65 5.28 0.21
70 INT250833 Localization of Fgf8 1 0.74 0.46 0.21
71 INT250842 Negative_regulation of Binding of Fgf8 1 0.43 0.33 0.21
72 INT135460 Gene_expression of DHCR24 2 0.58 0.57 0.2
73 INT134477 Negative_regulation of SHH 2 0.37 1.13 0.2
74 INT154282 Positive_regulation of Gene_expression of WT1 3 0.55 3.41 0.19
75 INT135459 Positive_regulation of Negative_regulation of DHCR24 1 0.38 0.18 0.19
76 INT159231 Positive_regulation of PDGFRA 3 0.47 2.39 0.18
77 INT99392 Negative_regulation of Localization of Ctnnb1 2 0.59 1.43 0.17
78 INT151721 Negative_regulation of Localization of Ctnnb1 1 0.23 0.96 0.17
79 INT13723 Negative_regulation of Positive_regulation of WT1 1 0.03 1.26 0.17
80 INT135461 Protein_catabolism of DHCR24 1 0.44 0.27 0.17
81 INT325506 Positive_regulation of Localization of Ctnnb1 1 0.05 0.28 0.17
82 INT232799 Regulation of Gene_expression of Shh 3 0.27 1.04 0.16
83 INT151741 Regulation of PDGFRA 2 0.44 0.78 0.16
84 INT253177 Negative_regulation of Gene_expression of Shh 2 0.55 0.63 0.16
85 INT319048 Transcription of WT1 2 0.56 1.87 0.16
86 INT101208 Positive_regulation of Gene_expression of Wt1 3 0.47 3.08 0.15
87 INT250835 Positive_regulation of Fgf8 1 0.50 0.42 0.14
88 INT253190 Localization of Shh 2 0.77 1.06 0.13
89 INT130374 Transcription of Ctnnb1 1 0.19 0 0.13
90 INT253183 Negative_regulation of Shh 8 0.55 2.13 0.12
91 INT201144 Regulation of Gene_expression of Sox2 3 0.44 0.82 0.11
92 INT236875 Localization of SRD5A1 2 0.73 0.8 0.11
93 INT178195 Localization of Wt1 4 0.69 2.64 0.1
94 INT201140 Transcription of Sox2 4 0.67 1.31 0.1
95 INT149266 Gene_expression of BMP6 2 0.77 0.56 0.1
96 INT153274 Gene_expression of LHCGR 2 0.67 1.53 0.1
97 INT270442 Transcription of Shh 1 0.53 0.25 0.09
98 INT213515 Binding of Shh 8 0.37 1.92 0.08
99 INT136182 Negative_regulation of PDGFRA 3 0.43 2.43 0.08
100 INT270453 Regulation of Shh 1 0.27 0.83 0.08
101 INT149264 Positive_regulation of Gene_expression of BMP6 1 0.69 0.34 0.08
102 INT232713 Binding of PDGFRA 1 0.35 1.43 0.08
103 INT168975 Binding of Wt1 14 0.43 7.37 0.07
104 INT166389 Binding of WT1 7 0.36 8.25 0.07
105 INT205973 Binding of SHH 3 0.35 1.03 0.07
106 INT149265 Localization of BMP6 1 0.74 0.31 0.07
107 INT256862 Regulation of Shh 1 0.25 0 0.07
108 INT236876 Negative_regulation of Localization of SRD5A1 1 0.41 0.81 0.06
109 INT307902 Negative_regulation of Localization of Wt1 1 0.34 0.21 0.05
110 INT270445 Positive_regulation of Localization of Shh 1 0.44 0.13 0.05
111 INT185260 Positive_regulation of Positive_regulation of Sox2 1 0.15 0 0.05
112 INT209191 Positive_regulation of LHCGR 1 0.28 0.05 0.05
113 INT181793 Positive_regulation of SHH 3 0.67 2.59 0.04
114 INT213537 Positive_regulation of Gene_expression of Sox2 3 0.48 1.34 0.04
115 INT208560 Negative_regulation of Shh 2 0.59 2.22 0.04
116 INT213528 Negative_regulation of Gene_expression of Sox2 1 0.30 0.07 0.04
117 INT254991 Negative_regulation of Gene_expression of BMP6 1 0.13 0.22 0.03
118 INT181604 Localization of WT1 1 0.63 1.41 0.03
119 INT253187 Negative_regulation of Transcription of Shh 1 0.41 0.55 0.03
120 INT253181 Transcription of Shh 1 0.68 0.54 0.03
121 INT285960 Negative_regulation of WT1 6 0.47 10.02 0
122 INT276530 Negative_regulation of Wt1 5 0.53 2.97 0
123 INT201142 Negative_regulation of Sox2 4 0.57 0.59 0
124 INT285959 Negative_regulation of Gene_expression of WT1 3 0.46 4.9 0
125 INT201141 Binding of Sox2 3 0.36 0.53 0
126 INT178534 Positive_regulation of SRD5A1 2 0.44 1.23 0
127 INT76959 Binding of Ctnnb1 2 0.34 0.69 0
128 INT276519 Regulation of Wt1 2 0.24 1.7 0
129 INT276550 Transcription of Wt1 2 0.66 1.35 0
130 INT236869 Negative_regulation of Negative_regulation of SRD5A1 2 0.41 2.68 0
131 INT230651 Phosphorylation of Ctnnb1 1 0.10 0 0
132 INT230674 Positive_regulation of Phosphorylation of Ctnnb1 1 0.06 0 0
133 INT276547 Positive_regulation of Binding of Wt1 1 0.63 0.29 0
134 INT326137 Protein_catabolism of Ctnnb1 1 0.02 1.08 0
135 INT320726 Negative_regulation of Gene_expression of TBX3 1 0.16 0.66 0
136 INT307906 Negative_regulation of Transcription of Wt1 1 0.54 1.3 0
137 INT355576 Negative_regulation of Negative_regulation of Ctnnb1 1 0.02 1.14 0
138 INT193182 Localization of DHCR24 1 0.10 0.22 0
139 INT352608 Binding of Pdgfra 1 0.27 0.7 0
140 INT209178 Regulation of Regulation of LHCGR 1 0.25 0 0
141 INT320733 Negative_regulation of TBX3 1 0.16 0.66 0
142 INT209186 Regulation of LHCGR 1 0.35 0 0
143 INT295427 Localization of PDGFRA 1 0.40 1.04 0
144 INT276551 Positive_regulation of Localization of Wt1 1 0.45 0 0
145 INT234505 Gene_expression of HOXD13 1 0.01 0 0
146 INT220769 Positive_regulation of Positive_regulation of Ctnnb1 1 0.10 0 0
147 INT320727 Positive_regulation of TBX3 1 0.19 0.84 0
148 INT163413 Positive_regulation of HOXD13 1 0.34 0 0
149 INT201146 Negative_regulation of Binding of Sox2 1 0.41 0.28 0
150 INT290918 Negative_regulation of Positive_regulation of Shh 1 0.41 0.25 0
151 INT352609 Positive_regulation of Gene_expression of Pdgfra 1 0.58 1.18 0
152 INT276534 Negative_regulation of Binding of Wt1 1 0.38 0 0
153 INT250830 Regulation of Protein_catabolism of Fgf8 1 0.45 0.08 0
154 INT311651 Positive_regulation of Fgf8 1 0.46 0.26 0
155 INT320720 Gene_expression of TBX3 1 0.29 3.53 0
156 INT201139 Localization of Sox2 1 0.73 0.15 0
157 INT230972 Positive_regulation of Gene_expression of SHH 1 0.18 0.07 0
158 INT319051 Regulation of Positive_regulation of WT1 1 0.36 1.11 0
159 INT250846 Positive_regulation of Protein_catabolism of Fgf8 1 0.50 0.07 0
160 INT200836 Transcription of Pdgfra 1 0.30 0.26 0
161 INT209188 Negative_regulation of Positive_regulation of LHCGR 1 0.24 0 0
162 INT290929 Binding of Shh 1 0.31 0.1 0
163 INT290927 Regulation of Positive_regulation of Shh 1 0.23 0 0
164 INT307903 Negative_regulation of Gene_expression of Wt1 1 0.39 1.31 0
165 INT270449 Negative_regulation of Positive_regulation of Shh 1 0.43 0.24 0
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