GO:0030552

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Name cAMP binding
Categary Function
Go Slim No
Go Link GO:0030552
Unique Molecular Interactions 62
Total Molecular Interactions 67
Total Single Events 591
Pain Genes Associated 15

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for cAMP binding. They are ordered first by their pain relevance and then by number of times they were reported for cAMP binding. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT169801 Binding of Adrbk1 and Rapgef3 1 0.34 1.04 1.43
2 INT169802 Negative_regulation of Adrbk1 Positive_regulation of Positive_regulation of Rapgef3 1 0.44 0.75 1.19
3 INT14197 Pde2a Positive_regulation of Localization of Gh1 2 0.04 0 1.08
4 INT265566 Binding of PDE4D and PTPN5 1 0.03 0.81 0.85
5 INT149925 Negative_regulation of Cpox Negative_regulation of Gene_expression of Pde4d 1 0.01 0.39 0.84
6 INT117217 Binding of Calca and Hcn2 1 0.25 0.17 0.68
7 INT273350 Pde7a Positive_regulation of Localization of Pde4d 1 0.33 1.35 0.49
8 INT275087 Pde2a Negative_regulation of stm 1 0.01 0.51 0.42
9 INT275104 Pde2a Negative_regulation of RTP3 1 0.00 0.51 0.42
10 INT145575 Binding of Adra2c and Hcn2 1 0.21 0.19 0.4
11 INT145577 Regulation of Binding of Adra2c and Hcn2 1 0.25 0.19 0.4
12 INT235125 PDE2A Negative_regulation of Twist1 1 0.00 0.99 0.24
13 INT163055 Negative_regulation of Pde10a Positive_regulation of Gene_expression of Qrfp 1 0.03 0 0.2
14 INT30071 Gm8212 Regulation of Pde3a 1 0.00 0 0.2
15 INT32162 POMC Negative_regulation of PDE11A 1 0.23 0 0.19
16 INT263179 PDE3A Regulation of COPD 1 0.00 1 0.15
17 INT219597 Prkaca Positive_regulation of Pde4d 1 0.29 0 0.15
18 INT263177 Binding of PDE3A and COPD 1 0.01 1 0.15
19 INT273017 Binding of PDE1B and PDE11A 1 0.08 0.35 0.14
20 INT135941 Positive_regulation of PDE2A Positive_regulation of Gene_expression of PRKG1 1 0.13 0.8 0.13
21 INT219599 Pde4d Regulation of Prkaca 1 0.28 0 0.12
22 INT273020 Binding of FGF9 and PDE11A 1 0.22 0.3 0.11
23 INT135943 Positive_regulation of PRKG1 Regulation of PDE2A 1 0.08 0.73 0.1
24 INT207682 Chrnb4 Positive_regulation of Hcn4 1 0.35 0.29 0.1
25 INT257217 Binding of Pde2a and Pde5a 1 0.03 0 0.1
26 INT219600 Pde4d Regulation of Binding of Prkaca 1 0.28 0 0.09
27 INT219602 Binding of Prkaca and Pde4d 1 0.23 0 0.09
28 INT148096 Vasp Regulation of Pde2a 1 0.00 0.23 0.08
29 INT98269 PDE2A Positive_regulation of PRKG1 1 0.07 0.57 0.08
30 INT98270 Positive_regulation of PDE2A Positive_regulation of PRKG1 1 0.07 0.57 0.08
31 INT273353 Pde4d Regulation of Gene_expression of Twist1 1 0.26 0.25 0.05
32 INT263197 Binding of PDE3A and Pde5a 1 0.03 0.18 0.04
33 INT149751 Rapgef3 Regulation of Phosphorylation of Akt1 1 0.50 0.39 0.04
34 INT325600 Nppa Positive_regulation of Pde2a 1 0.11 0.16 0.03
35 INT219596 Binding of Pde4a and Pde4d 1 0.28 0.31 0
36 INT308425 Binding of Pde2a and Aip 1 0.04 1.37 0
37 INT325602 Binding of Ang and Pde2a 1 0.07 0.15 0
38 INT121478 Binding of Pde3a and Positive_regulation of Localization of Ins1 1 0.24 0 0
39 INT186239 Binding of ROS1 and Positive_regulation of PDE2A 1 0.00 0 0
40 INT186241 Gene_expression of ROS1 Positive_regulation of PDE2A 1 0.00 0 0
41 INT325603 Pde2a Regulation of Rgs2 1 0.03 0 0
42 INT325613 Pls1 Regulation of Pde2a 1 0.00 0 0
43 INT325593 Pde2a Positive_regulation of Negative_regulation of Nppa 1 0.11 0 0
44 INT66168 Pde2a Negative_regulation of Adra2a 1 0.04 0 0
45 INT325612 Rgs2 Regulation of Pde2a 1 0.10 0 0
46 INT325609 Pde2a Positive_regulation of Gene_expression of Rgs2 1 0.12 0 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for cAMP binding. They are ordered first by their pain relevance and then by number of times they were reported in cAMP binding. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT138639 Gene_expression of Hcn4 32 0.75 13.85 11.25
2 INT117212 Gene_expression of Hcn2 13 0.78 5.83 8.19
3 INT160168 Gene_expression of Pde10a 10 0.74 8.66 7.94
4 INT188852 Gene_expression of Pde2a 13 0.19 6.44 5.35
5 INT105775 Gene_expression of Pde4d 31 0.78 4.18 5.21
6 INT121471 Negative_regulation of Pde3a 24 0.34 13.79 4.73
7 INT75815 Positive_regulation of PDE2A 10 0.40 5.1 3.15
8 INT141038 Positive_regulation of Gene_expression of Hcn4 4 0.38 3.58 3.12
9 INT159770 Positive_regulation of Gene_expression of Hcn2 2 0.67 2.65 2.82
10 INT30172 Positive_regulation of Pde2a 3 0.39 0.55 2.77
11 INT169798 Positive_regulation of Rapgef3 1 0.45 1.7 2.56
12 INT79399 Gene_expression of Pde4d 6 0.70 2.83 2.51
13 INT107489 Negative_regulation of Pde4d 3 0.42 0 2.47
14 INT137270 Positive_regulation of PDE4D 4 0.48 2.48 2.39
15 INT107490 Positive_regulation of Pde4d 3 0.69 0.07 2.13
16 INT105776 Negative_regulation of Gene_expression of Pde4d 5 0.59 2.2 2.01
17 INT117210 Binding of Hcn2 3 0.48 0.82 1.91
18 INT24909 Negative_regulation of Pde10a 4 0.43 0.87 1.87
19 INT64530 Negative_regulation of Positive_regulation of Pde2a 1 0.36 0 1.81
20 INT119905 Negative_regulation of PDE3A 5 0.18 5 1.77
21 INT148862 Positive_regulation of Hcn4 3 0.47 1.4 1.73
22 INT12781 Regulation of Pde2a 4 0.23 1.14 1.69
23 INT64529 Localization of Pde2a 1 0.59 0 1.63
24 INT1580 Negative_regulation of Pde2a 7 0.52 3.26 1.59
25 INT188855 Positive_regulation of Gene_expression of Pde2a 5 0.12 1.97 1.53
26 INT169799 Binding of Rapgef3 1 0.30 1.04 1.43
27 INT14195 Localization of Pde2a 4 0.16 0.34 1.33
28 INT135924 Positive_regulation of Gene_expression of Pde4d 2 0.59 0 1.28
29 INT149924 Negative_regulation of Gene_expression of Pde4d 1 0.26 0.81 1.24
30 INT149261 Negative_regulation of Hcn2 1 0.11 0.45 1.17
31 INT138640 Transcription of Hcn2 2 0.66 0.51 1.05
32 INT219589 Binding of Pde4d 13 0.47 0.51 1.01
33 INT7834 Gene_expression of Pde2a 5 0.51 1.9 1.01
34 INT219568 Positive_regulation of Pde4d 9 0.49 1.74 1
35 INT160171 Localization of Pde10a 2 0.77 1.26 0.95
36 INT188851 Regulation of Gene_expression of Pde2a 1 0.04 0.75 0.94
37 INT117215 Positive_regulation of Hcn2 1 0.50 0.15 0.92
38 INT265568 Binding of PDE4D 1 0.05 0.81 0.85
39 INT226473 Negative_regulation of PDE4D 5 0.19 3.54 0.83
40 INT89776 Positive_regulation of Pde2a 2 0.47 2.84 0.81
41 INT219578 Negative_regulation of Pde4d 3 0.46 2.95 0.8
42 INT144789 Negative_regulation of Hcn2 2 0.53 0.24 0.8
43 INT135923 Regulation of Gene_expression of Pde4d 2 0.44 0 0.8
44 INT118753 Regulation of Negative_regulation of Pde4d 1 0.02 0 0.8
45 INT98275 Negative_regulation of PDE2A 4 0.17 3.96 0.79
46 INT177533 Negative_regulation of Binding of Pde3a 1 0.21 2.46 0.76
47 INT159772 Regulation of Hcn2 1 0.26 0.53 0.71
48 INT117216 Localization of Hcn2 1 0.75 0.16 0.69
49 INT183161 Regulation of Pde2a 2 0.05 0.5 0.67
50 INT162911 Gene_expression of PDE3A 2 0.24 2.47 0.65
51 INT219580 Localization of Pde4d 5 0.73 2.07 0.64
52 INT138641 Transcription of Hcn4 1 0.54 0.51 0.64
53 INT213617 Gene_expression of PDE4D 3 0.53 1.98 0.62
54 INT75814 Regulation of Positive_regulation of PDE2A 1 0.23 0.26 0.56
55 INT79397 Positive_regulation of Gene_expression of Pde4d 1 0.45 0.2 0.55
56 INT132967 Gene_expression of Hcn2 2 0.71 0.09 0.54
57 INT219573 Positive_regulation of Localization of Pde4d 2 0.49 1.39 0.5
58 INT273179 Localization of PDE4D 1 0.34 2.01 0.5
59 INT245898 Negative_regulation of Hcn4 2 0.40 1.84 0.49
60 INT163499 Regulation of Gene_expression of Hcn4 1 0.23 0.9 0.49
61 INT162903 Localization of PDE2A 2 0.61 0.89 0.45
62 INT121469 Binding of Pde3a 2 0.23 1.42 0.44
63 INT216759 Binding of PDE2A 1 0.00 0.08 0.44
64 INT144790 Negative_regulation of Negative_regulation of Hcn2 1 0.53 0.06 0.4
65 INT219565 Regulation of Pde4d 3 0.44 0.5 0.39
66 INT273330 Positive_regulation of Negative_regulation of Pde4d 1 0.39 1.25 0.35
67 INT235122 Negative_regulation of Positive_regulation of PDE2A 1 0.01 0.72 0.35
68 INT235113 Positive_regulation of Negative_regulation of PDE2A 1 0.01 0.72 0.35
69 INT135945 Positive_regulation of Positive_regulation of PDE2A 2 0.12 0.78 0.34
70 INT136943 Positive_regulation of Rapgef3 2 0.67 1.25 0.33
71 INT219588 Negative_regulation of Gene_expression of Pde3a 1 0.25 0 0.32
72 INT219563 Gene_expression of Pde3a 1 0.39 0 0.32
73 INT207667 Binding of Hcn4 2 0.35 0 0.28
74 INT160733 Regulation of Hcn4 1 0.50 0.12 0.28
75 INT273021 Binding of PDE11A 1 0.35 0.78 0.26
76 INT273341 Transcription of Pde4d 2 0.54 0.68 0.24
77 INT273336 Regulation of Negative_regulation of Pde4d 1 0.35 0.68 0.24
78 INT245900 Regulation of Binding of Hcn4 1 0.36 0 0.22
79 INT273181 Negative_regulation of Localization of PDE4D 1 0.18 0.68 0.2
80 INT30069 Regulation of Pde3a 1 0.06 0 0.2
81 INT32164 Positive_regulation of PDE11A 1 0.26 0 0.19
82 INT275543 Negative_regulation of Gene_expression of PDE4D 1 0.11 0.87 0.19
83 INT263126 Negative_regulation of Binding of PDE3A 1 0.13 0.62 0.18
84 INT163053 Regulation of Negative_regulation of Pde10a 1 0.45 0 0.18
85 INT98276 Regulation of PDE2A 2 0.07 1.54 0.17
86 INT219576 Positive_regulation of Gene_expression of Pde3a 1 0.29 0 0.17
87 INT219593 Regulation of Binding of Pde4d 1 0.44 0 0.13
88 INT84749 Gene_expression of PDE2A 3 0.73 0.84 0.12
89 INT135946 Positive_regulation of Gene_expression of PDE2A 1 0.12 0.77 0.12
90 INT273022 Negative_regulation of PDE11A 1 0.40 0.24 0.11
91 INT135944 Regulation of Regulation of PDE2A 1 0.07 0.73 0.1
92 INT219574 Phosphorylation of Pde4d 1 0.79 0.33 0.1
93 INT263134 Binding of PDE3A 1 0.15 0.47 0.09
94 INT245896 Negative_regulation of Gene_expression of Hcn4 1 0.47 1.35 0.09
95 INT80630 Protein_catabolism of PDE2A 2 0.19 0.91 0.08
96 INT111440 Negative_regulation of Gene_expression of Pde2a 1 0.20 1.14 0.07
97 INT149746 Gene_expression of Rapgef3 1 0.04 0.75 0.06
98 INT219585 Positive_regulation of Positive_regulation of Pde4d 1 0.43 0 0.06
99 INT149748 Positive_regulation of Gene_expression of Rapgef3 1 0.03 0.75 0.06
100 INT183439 Protein_catabolism of Pde2a 1 0.14 0.84 0.05
101 INT183425 Negative_regulation of Protein_catabolism of Pde2a 1 0.09 0.84 0.05
102 INT183437 Regulation of Pde10a 1 0.05 0.4 0.04
103 INT183433 Regulation of Localization of Pde2a 1 0.09 0.34 0.04
104 INT183438 Regulation of Localization of Pde10a 1 0.08 0.4 0.04
105 INT303887 Regulation of Negative_regulation of Hcn4 1 0.31 0.33 0.04
106 INT263142 Positive_regulation of Negative_regulation of PDE3A 1 0.15 0.15 0.03
107 INT149749 Negative_regulation of Rapgef3 1 0.04 0.44 0.03
108 INT263131 Localization of PDE3A 1 0.23 0.35 0.03
109 INT248265 Regulation of Pde4d 1 0.21 0.87 0
110 INT162918 Transcription of PDE2A 1 0.65 0 0
111 INT162919 Regulation of Transcription of PDE3A 1 0.06 0 0
112 INT162923 Regulation of PDE3A 1 0.06 0 0
113 INT162909 Gene_expression of PDE11A 1 0.17 0 0
114 INT162914 Regulation of Localization of PDE2A 1 0.37 0 0
115 INT219570 Negative_regulation of Positive_regulation of Pde4d 1 0.42 0 0
116 INT263132 Phosphorylation of PDE3A 1 0.25 0.19 0
117 INT263119 Positive_regulation of Phosphorylation of PDE3A 1 0.21 0.19 0
118 INT219575 Positive_regulation of Binding of Pde4d 1 0.49 0 0
119 INT162916 Negative_regulation of Transcription of PDE2A 1 0.40 0 0
120 INT263123 Positive_regulation of PDE3A 1 0.21 0.19 0
121 INT263136 Positive_regulation of Positive_regulation of PDE3A 1 0.21 0.19 0
122 INT183430 Binding of Pde2a 1 0.07 0 0
123 INT162904 Transcription of PDE3A 1 0.07 0 0
124 INT325558 Negative_regulation of Gene_expression of Pde2a 1 0.11 0.38 0
125 INT80629 Negative_regulation of Protein_catabolism of PDE2A 1 0.12 0.18 0
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