GO:0030641

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Name regulation of cellular pH
Categary Process
Go Slim No
Go Link GO:0030641
Unique Molecular Interactions 115
Total Molecular Interactions 159
Total Single Events 2254
Pain Genes Associated 2

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for regulation of cellular pH. They are ordered first by their pain relevance and then by number of times they were reported for regulation of cellular pH. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT208991 Binding of CALM1 and Ca2 10 0.06 1.34 1.55
2 INT208980 Binding of Ca2 and Trpv1 4 0.32 0.67 1.55
3 INT285185 Binding of Ca2 and Cd2 1 0.25 0.24 1.21
4 INT110435 Positive_regulation of Grm8 Positive_regulation of Localization of Ca2 1 0.38 0 1.21
5 INT353690 Binding of Grin2b and Ca2 1 0.14 1.17 1.01
6 INT214408 ATP1A4 Regulation of DNAH8 1 0.04 1.01 0.94
7 INT214409 ATP1A4 Regulation of CAPN1 1 0.01 1.01 0.93
8 INT270217 Binding of C2 and Ca2 1 0.03 1.63 0.81
9 INT251172 Trpv1 Regulation of Gene_expression of Ca2 1 0.13 0.7 0.81
10 INT322128 Binding of Ca2 and Trpv4 1 0.03 1.1 0.75
11 INT208978 Ca2 Positive_regulation of Trpv1 1 0.22 0.29 0.71
12 INT214410 Binding of ATP1A4 and CACNA1A 1 0.26 0.95 0.7
13 INT251169 Clu Regulation of Ca2 1 0.03 0.66 0.7
14 INT251165 Trpv1 Positive_regulation of Gene_expression of Ca2 1 0.15 0.54 0.65
15 INT50816 Penk Positive_regulation of Localization of Ca2 1 0.32 0 0.62
16 INT70254 Binding of Htr1a and Ca2 1 0.31 0.5 0.6
17 INT208984 Binding of Ca2 and Fig4 1 0.02 0 0.54
18 INT216918 Binding of Ca2 and Abat 1 0.01 0.45 0.53
19 INT118138 Binding of Ca2 and Mgat4a 1 0.01 0 0.53
20 INT297479 Ryr2 Positive_regulation of Ca2 1 0.22 0 0.52
21 INT330796 P2ry1 Positive_regulation of Ca2 1 0.05 0.06 0.5
22 INT250077 Positive_regulation of Ltp Positive_regulation of Localization of Ca2 1 0.10 0 0.48
23 INT259208 Ca2 Positive_regulation of Phosphorylation of Creb1 1 0.04 0 0.45
24 INT254460 Binding of Calm2 and Ca2 5 0.03 0.48 0.43
25 INT15028 NA Positive_regulation of Localization of Ca2 1 0.04 0 0.39
26 INT179207 KCNAB2 Regulation of Gene_expression of ATP1A4 1 0.00 1.25 0.37
27 INT33862 Ca2 Positive_regulation of Positive_regulation of Sult1b1 1 0.07 0.07 0.37
28 INT320591 Ca2 Positive_regulation of Nos1 1 0.07 0.09 0.37
29 INT263226 Prkcg Negative_regulation of Positive_regulation of Ca2 1 0.01 0.58 0.36
30 INT353689 Binding of Slc8a1 and Ca2 1 0.15 0.58 0.33
31 INT241966 Binding of Ca2 and Acpt 1 0.06 0.06 0.33
32 INT322129 Binding of Prkcg and Ca2 1 0.00 0.57 0.33
33 INT322133 Trpv4 Regulation of Ca2 1 0.04 0.16 0.33
34 INT34449 Binding of Ca2 and Pck1 1 0.17 0.18 0.33
35 INT241971 Ca2 Regulation of Localization of Abat 1 0.01 0 0.31
36 INT156261 Negative_regulation of Binding of Oxt and Ca2 1 0.16 0.12 0.3
37 INT26738 Ca2 Positive_regulation of Localization of Ins1 1 0.12 0.09 0.3
38 INT156262 Binding of Oxt and Ca2 1 0.14 0.12 0.3
39 INT154834 Stim1 Regulation of Regulation of Ca2 1 0.13 0.9 0.28
40 INT305623 Ca2 Positive_regulation of Cabin1 1 0.00 0.27 0.27
41 INT322127 Binding of Mbp and Ca2 1 0.01 0.39 0.27
42 INT272174 Acot1 Regulation of Ca2 1 0.01 0 0.26
43 INT35022 Ptz1b Positive_regulation of Ca2 1 0.01 0 0.25
44 INT35020 Regulation of Ptz1b Positive_regulation of Ca2 1 0.01 0 0.25
45 INT283028 Nav1 Regulation of Ca2 1 0.08 0 0.24
46 INT283027 Pirt Regulation of Ca2 1 0.00 0 0.24
47 INT52585 RPL35AP35 Positive_regulation of Positive_regulation of Ca2 1 0.00 0.34 0.24
48 INT330797 Positive_regulation of Accn2 Positive_regulation of Ca2 1 0.03 0 0.23
49 INT268946 Ros1 Regulation of Gene_expression of Ca2 1 0.00 0.18 0.23
50 INT191480 Htr3a Positive_regulation of Ca2 1 0.02 0.12 0.23
51 INT353691 Slc8a1 Positive_regulation of Ca2 1 0.18 0.45 0.22
52 INT330546 Positive_regulation of Trpm8 Positive_regulation of Positive_regulation of Ca2 1 0.13 0.67 0.22
53 INT290855 PPR Regulation of Ca2 1 0.01 0.45 0.2
54 INT330795 Positive_regulation of Accn2 Positive_regulation of Positive_regulation of Ca2 1 0.03 0 0.18
55 INT290858 Positive_regulation of Ca2 Regulation of PPR 1 0.01 0.5 0.18
56 INT285183 Cd2 Regulation of Ca2 1 0.30 0.23 0.18
57 INT290856 Ca2 Regulation of PPR 1 0.01 0.5 0.18
58 INT216487 Ca2 Negative_regulation of Kcnma1 1 0.00 0.1 0.17
59 INT40845 Ca2 Positive_regulation of Pla2g1b 1 0.16 0 0.16
60 INT5737 Hk1 Positive_regulation of Ca2 1 0.06 0.16 0.16
61 INT216601 Itpr3 Positive_regulation of Localization of Ca2 1 0.00 0.05 0.15
62 INT342150 Ca2 Positive_regulation of Localization of Gast 1 0.03 0.27 0.14
63 INT216787 Svs4 Positive_regulation of Ca2 1 0.06 0 0.13
64 INT216791 Regulation of Svs4 Positive_regulation of Ca2 1 0.02 0 0.13
65 INT329473 SLC7A7 Regulation of Ca2 1 0.04 0.1 0.13
66 INT216486 Pck1 Regulation of Gene_expression of Ca2 1 0.05 0.19 0.13
67 INT208983 Binding of Ca2 and Kcnma1 2 0.01 0.28 0.1
68 INT341880 Oxt Positive_regulation of Ca2 1 0.09 0 0.1
69 INT254456 Negative_regulation of Binding of Calm2 and Ca2 1 0.03 0 0.1
70 INT341877 Oxtr Regulation of Ca2 1 0.08 0 0.09
71 INT29838 Gnrh1 Positive_regulation of Localization of Ca2 1 0.17 0 0.09
72 INT241040 Slc8a1 Negative_regulation of Gene_expression of Ca2 1 0.15 1.35 0.09
73 INT329474 Binding of SLC7A7 and Ca2 1 0.03 0.4 0.08
74 INT215767 Binding of P2ry1 and Ca2 1 0.02 0.2 0.08
75 INT254459 Ca2 Positive_regulation of Calm2 1 0.03 0 0.08
76 INT200536 Ca2 Positive_regulation of NOS1 1 0.03 0.74 0.07
77 INT254462 Binding of Ca2 and Creb1 1 0.16 0 0.07
78 INT201172 Sox2 Positive_regulation of Localization of Ca2 1 0.47 0.9 0.07
79 INT295295 Tlr4 Positive_regulation of Ca2 1 0.00 0.34 0.05
80 INT348715 Positive_regulation of Binding of Ca2 and Mylk 1 0.02 0.47 0.05
81 INT285184 Negative_regulation of Atp2a2 Negative_regulation of Localization of Ca2 1 0.04 0.66 0.05
82 INT240726 Binding of Esr1 and Ca2 1 0.02 0.57 0.05
83 INT348716 Binding of Ca2 and Mylk 1 0.02 0.47 0.05
84 INT329468 Gpr55 Positive_regulation of Positive_regulation of Ca2 1 0.07 0.49 0.05
85 INT249988 Agt Regulation of Ca2 1 0.18 0.9 0.04
86 INT216786 Ca2 Positive_regulation of Gtf3a 1 0.01 0 0.04
87 INT249990 Agt Positive_regulation of Positive_regulation of Ca2 1 0.20 0.65 0.04
88 INT249989 Agt Positive_regulation of Ca2 1 0.20 1.6 0.04
89 INT255659 Binding of Anxa5 and Ca2 1 0.02 1.23 0.04
90 INT215810 Positive_regulation of Binding of Ca2 and Orai1 1 0.01 0.06 0.03
91 INT318073 Itpr3 Regulation of Ca2 1 0.01 0 0.03
92 INT215811 Binding of Ca2 and Orai1 1 0.01 0.06 0.03
93 INT216790 Svs4 Positive_regulation of Negative_regulation of Ca2 1 0.04 0 0
94 INT256081 Serpina3k Negative_regulation of Ca2 1 0.05 0.07 0
95 INT329472 Binding of IRF6 and Ca2 1 0.00 0.26 0
96 INT309060 Trpc5 Positive_regulation of Ca2 1 0.11 0.06 0
97 INT329478 SLC7A7 Positive_regulation of Ca2 1 0.04 0 0
98 INT31765 Positive_regulation of Binding of Itpr3 and Ca2 1 0.21 0 0
99 INT263182 Ca2 Positive_regulation of Phosphorylation of Pde1b 1 0.01 0 0
100 INT261883 PKD2 Positive_regulation of Localization of Ca2 1 0.02 0.67 0
101 INT240722 Cd38 Positive_regulation of Localization of Ca2 1 0.04 0.79 0
102 INT256077 Serpina3k Positive_regulation of Gene_expression of Ca2 1 0.06 0.17 0
103 INT256073 Negative_regulation of Serpina3k Positive_regulation of Ca2 1 0.05 0.17 0
104 INT240723 Atp2b2 Positive_regulation of Localization of Ca2 1 0.11 0.43 0
105 INT240724 Atp2b2 Positive_regulation of Ca2 1 0.11 0.54 0
106 INT304944 Positive_regulation of Binding of Tnp1 and Ca2 1 0.04 0.33 0
107 INT298103 Binding of Cav1 and Ca2 1 0.03 0 0
108 INT298105 Ca2 Negative_regulation of Cd1d1 1 0.12 0.09 0
109 INT309061 Trpc5 Positive_regulation of Gene_expression of Ca2 1 0.08 0.06 0
110 INT298104 Ca2 Negative_regulation of Cav1 1 0.04 0.09 0
111 INT240725 Esr1 Positive_regulation of Localization of Ca2 1 0.03 0.72 0
112 INT256080 Serpina3k Positive_regulation of Ca2 1 0.06 0.17 0
113 INT298124 Ca2 Negative_regulation of CALM1 1 0.00 0.17 0
114 INT304945 Binding of Tnp1 and Ca2 1 0.03 0.97 0
115 INT31766 Binding of Itpr3 and Ca2 1 0.16 0 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for regulation of cellular pH. They are ordered first by their pain relevance and then by number of times they were reported in regulation of cellular pH. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT1033 Positive_regulation of Ca2 507 0.68 131.76 147.64
2 INT4822 Localization of Ca2 417 0.80 99.57 96.45
3 INT2520 Negative_regulation of Ca2 271 0.57 72.13 83.71
4 INT13286 Gene_expression of Ca2 317 0.67 71.58 65.01
5 INT1032 Regulation of Ca2 202 0.52 54.91 53.03
6 INT14546 Positive_regulation of Localization of Ca2 93 0.67 31.09 18.72
7 INT113625 Positive_regulation of Gene_expression of Ca2 47 0.50 9.82 14.07
8 INT19799 Binding of Ca2 71 0.48 13.69 12.92
9 INT33094 Regulation of Localization of Ca2 28 0.38 8.65 9.96
10 INT23094 Positive_regulation of Positive_regulation of Ca2 29 0.49 6.8 9.35
11 INT19366 Negative_regulation of Localization of Ca2 33 0.50 6.51 6.61
12 INT149739 Regulation of Gene_expression of Ca2 25 0.38 7.22 5.53
13 INT6983 Negative_regulation of Positive_regulation of Ca2 18 0.41 4.29 5.03
14 INT15549 Regulation of Positive_regulation of Ca2 11 0.38 2.55 2.92
15 INT2042 Phosphorylation of Ca2 21 0.55 1.54 2.81
16 INT70253 Negative_regulation of Gene_expression of Ca2 29 0.49 16.31 2.69
17 INT72743 Positive_regulation of Negative_regulation of Ca2 4 0.49 1.41 2.11
18 INT19798 Positive_regulation of Binding of Ca2 2 0.41 1.37 1.54
19 INT119936 Transcription of Ca2 13 0.59 1.71 1.47
20 INT103960 Gene_expression of ATP1A4 4 0.73 3.05 1.34
21 INT179217 Positive_regulation of ATP1A4 2 0.11 0.91 1.34
22 INT49536 Regulation of Regulation of Ca2 6 0.38 3.89 1.13
23 INT214417 Regulation of ATP1A4 1 0.38 1.01 0.93
24 INT21246 Negative_regulation of ATP1A4 3 0.10 3.3 0.79
25 INT287841 Positive_regulation of Phosphorylation of Ca2 2 0.18 0.58 0.75
26 INT23095 Negative_regulation of Regulation of Ca2 2 0.36 0.34 0.56
27 INT32137 Regulation of Negative_regulation of Ca2 7 0.36 2.17 0.49
28 INT2043 Negative_regulation of Phosphorylation of Ca2 2 0.38 0 0.38
29 INT179223 Regulation of Gene_expression of ATP1A4 1 0.02 1.23 0.37
30 INT179215 Positive_regulation of Gene_expression of ATP1A4 1 0.06 0.24 0.28
31 INT149737 Positive_regulation of Regulation of Ca2 3 0.58 1 0.27
32 INT32301 Regulation of Binding of Ca2 5 0.38 1.07 0.24
33 INT179220 Negative_regulation of Gene_expression of ATP1A4 1 0.04 1.11 0.24
34 INT201150 Protein_catabolism of Ca2 4 0.75 2.63 0.21
35 INT235620 Regulation of Transcription of Ca2 1 0.38 0 0.2
36 INT240712 Negative_regulation of Negative_regulation of Ca2 4 0.36 0.38 0.19
37 INT41962 Negative_regulation of Binding of Ca2 2 0.37 0.18 0.1
38 INT216809 Positive_regulation of Transcription of Ca2 2 0.40 0.08 0.09
39 INT287851 Regulation of Phosphorylation of Ca2 1 0.10 0.19 0.03
40 INT287400 Negative_regulation of Transcription of Ca2 1 0.33 0 0
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