GO:0030644

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Name cellular chloride ion homeostasis
Categary Process
Go Slim No
Go Link GO:0030644
Unique Molecular Interactions 113
Total Molecular Interactions 170
Total Single Events 1360
Pain Genes Associated 11

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for cellular chloride ion homeostasis. They are ordered first by their pain relevance and then by number of times they were reported for cellular chloride ion homeostasis. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT140347 Binding of ATP1A2 and Cacna1a 1 0.11 2.88 2.73
2 INT74840 Binding of Cacna1a and Cacna1a 5 0.00 4.24 2.36
3 INT122660 Binding of CACNA1A and DNAH8 2 0.28 2.68 2.08
4 INT355251 Cacna1a Regulation of Gene_expression of Gabrg1 1 0.01 0.06 1.86
5 INT355249 Cacna1a Regulation of Gene_expression of Ltp 1 0.04 0.06 1.86
6 INT355254 Ltp Regulation of Cacna1a 1 0.04 0 1.58
7 INT74843 Binding of Cacna1a and Ea2 3 0.13 3.29 1.55
8 INT355250 Ltp Regulation of Positive_regulation of Cacna1a 1 0.04 0 1.39
9 INT108727 Binding of ATP1A2 and CACNA1A 2 0.34 1.97 1.37
10 INT122659 Binding of CACNA1A and SAR1B 1 0.06 1.38 1.35
11 INT355253 Ltp Positive_regulation of Cacna1a 1 0.05 0 1.34
12 INT355252 Binding of Cacna1a and Cnr1 1 0.04 0 1.31
13 INT74841 Binding of Cacna1a and Ea2 2 0.01 2.33 1.27
14 INT91813 Binding of FAS and FASLG 4 0.23 9.89 0.99
15 INT108729 Binding of CACNA1A and Cacna1a 3 0.13 1.21 0.95
16 INT130769 FASLG Negative_regulation of Binding of FAS 1 0.10 0.66 0.86
17 INT120293 RYBP Positive_regulation of Abcc2 1 0.04 0.14 0.86
18 INT155220 ABCG2 Positive_regulation of Abcc2 1 0.23 0.54 0.76
19 INT228499 Binding of FAS and Fasl 1 0.15 2.75 0.73
20 INT214410 Binding of ATP1A4 and CACNA1A 1 0.26 0.95 0.7
21 INT31416 Cacna1a Positive_regulation of Gene_expression of Gcg 1 0.03 0 0.65
22 INT120294 RYBP Positive_regulation of Positive_regulation of Abcc2 1 0.02 0.15 0.61
23 INT88024 Ifng Positive_regulation of Gene_expression of Faslg 2 0.50 1.19 0.53
24 INT292873 Binding of Fas and Fasl 5 0.26 15.74 0.49
25 INT354986 Cacna1a Regulation of Localization of Mpo 1 0.01 1.15 0.49
26 INT130310 Ccl4 Positive_regulation of Abcc2 1 0.44 0.28 0.47
27 INT117776 Binding of Ptk2 and Regulation of Phosphorylation of Ddr1 1 0.10 0.17 0.46
28 INT354981 Cacna1a Negative_regulation of Gene_expression of Nos2 1 0.01 0.99 0.45
29 INT262220 Positive_regulation of Nr1i2 Positive_regulation of Gene_expression of Abcc2 1 0.14 0.25 0.44
30 INT254347 FASLG Negative_regulation of Gene_expression of CHI3L1 1 0.13 0.92 0.42
31 INT155752 Binding of CACNA1A and ATCAY 1 0.04 0.86 0.42
32 INT254350 FASLG Negative_regulation of Gene_expression of VEGFA 1 0.06 0.92 0.42
33 INT354984 Binding of Cacna1a and Tnf 1 0.01 0.83 0.4
34 INT355018 Binding of FAS and Faslg 1 0.12 1.34 0.37
35 INT158355 Cacna1a Regulation of Alox5 1 0.01 0.7 0.37
36 INT176373 IL18 Regulation of FASLG 1 0.41 0.4 0.35
37 INT354985 Cacna1a Regulation of Nos2 1 0.01 0.73 0.34
38 INT354982 Cacna1a Regulation of Tnf 1 0.00 0.73 0.34
39 INT301054 Tfap2a Regulation of Gene_expression of Faslg 1 0.00 1.23 0.34
40 INT101551 Binding of CACNA1A and CACNA1F 1 0.07 1.51 0.33
41 INT151258 Binding of Cacna1a and FCMTE1 1 0.00 0.57 0.3
42 INT295360 Ntn1 Positive_regulation of Ptk2 1 0.09 0.51 0.29
43 INT142003 Binding of Cacna1a and Etax2 1 0.00 1.02 0.26
44 INT142004 Binding of Cacna1a and TGM6 1 0.00 1.02 0.26
45 INT262202 Nr1i2 Regulation of Abcc2 1 0.19 0.12 0.25
46 INT262152 Nr1h4 Regulation of Abcc2 1 0.07 0.12 0.25
47 INT143809 Negative_regulation of Abcc2 Positive_regulation of Positive_regulation of H2-M3 1 0.04 0 0.25
48 INT300469 Ros1 Regulation of Gene_expression of Fasl 1 0.03 0.88 0.2
49 INT121807 CACNA1A Regulation of CAV2 1 0.01 0.25 0.2
50 INT88022 Tnf Positive_regulation of Gene_expression of Faslg 1 0.26 0.76 0.2
51 INT138427 Abcc2 Regulation of Abcg2 1 0.30 0 0.17
52 INT175328 FASLG Positive_regulation of FAS 1 0.01 0.9 0.17
53 INT91812 Binding of FASLG and TP53 1 0.04 1.1 0.16
54 INT234720 Cxcl1 Positive_regulation of Gene_expression of Faslg 1 0.08 0.2 0.16
55 INT234719 Cxcl1 Regulation of Gene_expression of Faslg 1 0.08 0.2 0.15
56 INT71329 Cacna1a Regulation of Ea2 1 0.01 0.71 0.15
57 INT71328 Cacna1a Regulation of Atxn2 1 0.00 0.71 0.15
58 INT307075 Tbxas1 Negative_regulation of Negative_regulation of PLG 1 0.01 1.22 0.11
59 INT327405 Lox Positive_regulation of Ptk2 1 0.42 1.3 0.1
60 INT120559 Binding of Cacna1a and FCMTE1 1 0.02 0.25 0.1
61 INT277090 VEGFA Positive_regulation of Negative_regulation of Faslg 1 0.02 1.67 0.09
62 INT274233 Negative_regulation of Binding of Cd4 and Fasl 1 0.13 0.91 0.08
63 INT274232 Binding of Cd4 and Fasl 1 0.11 0.9 0.08
64 INT91810 Binding of FASLG and TNF 1 0.05 0.92 0.08
65 INT196213 REST Regulation of Gene_expression of CACNA1A 1 0.46 0.08 0.08
66 INT329265 Binding of Ptk2 and Wnt2 1 0.05 1.04 0.07
67 INT274231 Fasl Positive_regulation of Gene_expression of Cd8a 1 0.03 1.01 0.07
68 INT333260 Gene_expression of Cxcl12 Negative_regulation of Gene_expression of Ptk2 1 0.21 1 0.07
69 INT333257 Gene_expression of Cxcl12 Negative_regulation of Ptk2 1 0.21 1 0.07
70 INT335712 Binding of FASLG and CD8A 1 0.18 0.9 0.06
71 INT335715 Binding of FASLG and CD4 1 0.22 0.9 0.06
72 INT330852 Fasl Positive_regulation of TRAT1 1 0.05 0.4 0.06
73 INT269249 Ptk2 Positive_regulation of Phosphorylation of Src 1 0.13 0.93 0.04
74 INT228136 Trav6-3 Positive_regulation of Positive_regulation of Fasl 1 0.14 0.59 0.04
75 INT354983 Cacna1a Regulation of Mpo 1 0.02 0.41 0.04
76 INT269250 Ptk2 Positive_regulation of Src 1 0.13 0.86 0.04
77 INT354987 Cacna1a Regulation of Localization of LDHA 1 0.00 0.23 0.03
78 INT176283 Fasl Positive_regulation of Fas 1 0.21 0.3 0.03
79 INT210154 TXN Regulation of Gene_expression of FASLG 1 0.09 0.23 0.03
80 INT292872 Binding of Fasl and Tg(MMTV-Notch4)3Rnc 1 0.05 1.25 0.03
81 INT271526 Binding of ESB3 and Ptk2 1 0.01 0.97 0.03
82 INT176286 Fasl Positive_regulation of Gene_expression of Pcna 1 0.02 0.81 0.03
83 INT351680 Fut1 Regulation of Ptk2 1 0.01 1.68 0
84 INT196208 REST Regulation of CACNA1A 1 0.46 0.06 0
85 INT196216 Binding of CACNA1A and REST 1 0.28 0 0
86 INT228135 Positive_regulation of Trav6-3 Positive_regulation of Fasl 1 0.14 1.39 0
87 INT261963 Binding of Cacna1a and Tgm2 1 0.08 1.19 0
88 INT351951 Negative_regulation of Binding of Fas and Fasl 1 0.29 1.13 0
89 INT176292 Fasl Regulation of Gene_expression of CDKN1A 1 0.34 0.84 0
90 INT269248 Lox Negative_regulation of Ptk2 1 0.24 1.02 0
91 INT250496 Gopc Regulation of Positive_regulation of Cacna1a 1 0.37 0 0
92 INT232004 Mapk8 Positive_regulation of Transcription of Fasl 1 0.05 0.65 0
93 INT295409 Ptk2 Positive_regulation of Phosphorylation of Oprk1 1 0.01 0 0
94 INT176291 Fasl Regulation of Gene_expression of Pcna 1 0.01 0.31 0
95 INT228138 Trav6-3 Positive_regulation of Fasl 1 0.14 1.38 0
96 INT307074 Binding of Plg and Tbxas1 1 0.00 0.14 0
97 INT176290 Fasl Positive_regulation of Pcna 1 0.02 0.44 0
98 INT176285 Fasl Regulation of Gene_expression of Cdc2b 1 0.03 0.34 0
99 INT232003 Cd36 Positive_regulation of Transcription of Fasl 1 0.10 0.66 0
100 INT295402 Ptk2 Positive_regulation of Localization of Oprk1 1 0.01 0 0
101 INT351676 Fut1 Negative_regulation of Ptk2 1 0.01 4.39 0
102 INT232007 Ahsa1 Positive_regulation of Transcription of Fasl 1 0.03 0.65 0
103 INT351677 Fut1 Negative_regulation of Gene_expression of Ptk2 1 0.01 3.64 0
104 INT176293 Fasl Positive_regulation of Gene_expression of CDKN1A 1 0.35 0.42 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for cellular chloride ion homeostasis. They are ordered first by their pain relevance and then by number of times they were reported in cellular chloride ion homeostasis. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT66331 Gene_expression of Cacna1a 101 0.78 49.58 46.32
2 INT26698 Positive_regulation of Cacna1a 37 0.67 26.33 39.1
3 INT41487 Negative_regulation of Cacna1a 16 0.57 9.42 25.2
4 INT93626 Gene_expression of Fasl 118 0.75 115.24 25.11
5 INT31136 Binding of Cacna1a 28 0.45 30.76 17.35
6 INT30101 Regulation of Cacna1a 25 0.45 14.38 12.43
7 INT93620 Positive_regulation of Gene_expression of Fasl 51 0.66 59.45 12.04
8 INT75765 Positive_regulation of Gene_expression of Cacna1a 17 0.70 17.51 10.91
9 INT104502 Gene_expression of Abcc2 26 0.78 8.37 9.65
10 INT86851 Gene_expression of Faslg 45 0.75 24.42 9.21
11 INT68267 Gene_expression of CACNA1A 22 0.75 11.39 8.65
12 INT95133 Gene_expression of FASLG 38 0.75 44.09 7.51
13 INT99942 Positive_regulation of Fasl 37 0.68 32.61 6.92
14 INT91821 Binding of Cacna1a 16 0.48 13.1 6.37
15 INT120286 Positive_regulation of Abcc2 11 0.70 4.71 6.2
16 INT83597 Phosphorylation of Ptk2 20 0.82 3.24 5.7
17 INT129508 Localization of Cacna1a 7 0.74 6.47 5.13
18 INT88019 Positive_regulation of Gene_expression of Faslg 16 0.67 11.31 5.05
19 INT110796 Positive_regulation of Positive_regulation of Cacna1a 1 0.49 0.51 4.84
20 INT82731 Transcription of Cacna1a 5 0.56 3.41 4.27
21 INT287526 Negative_regulation of Gene_expression of CACNA1A 1 0.42 4.25 3.81
22 INT117773 Positive_regulation of Phosphorylation of Ptk2 9 0.69 0.89 3.71
23 INT53516 Binding of CACNA1A 9 0.47 6.86 3.36
24 INT94045 Regulation of Cacna1a 5 0.42 3.56 3.33
25 INT133768 Regulation of Fasl 10 0.44 10.24 3.32
26 INT188406 Binding of Fasl 19 0.44 24.67 3.17
27 INT78317 Regulation of CACNA1A 8 0.62 7.68 3.08
28 INT85572 Gene_expression of Cacna1a 11 0.66 5.72 3.02
29 INT142940 Positive_regulation of Negative_regulation of Cacna1a 3 0.50 1.65 2.97
30 INT355244 Negative_regulation of Negative_regulation of Cacna1a 1 0.04 0 2.67
31 INT107302 Negative_regulation of Gene_expression of Fasl 7 0.42 8.52 2.54
32 INT95136 Binding of FASLG 6 0.33 8.01 2.41
33 INT131332 Negative_regulation of Gene_expression of Abcc2 7 0.58 1.25 2.35
34 INT137960 Positive_regulation of FASLG 8 0.67 6.5 2.34
35 INT133766 Negative_regulation of Fasl 11 0.56 11.28 2.27
36 INT93395 Transcription of Faslg 6 0.51 5.64 2.26
37 INT161575 Localization of CACNA1A 4 0.75 5.28 2.26
38 INT110795 Regulation of Positive_regulation of Cacna1a 2 0.26 0.65 2.07
39 INT88016 Negative_regulation of Gene_expression of Faslg 5 0.54 2.18 1.93
40 INT102147 Negative_regulation of Faslg 5 0.19 4.56 1.92
41 INT83596 Gene_expression of Ptk2 6 0.76 2.22 1.84
42 INT130775 Regulation of FASLG 4 0.30 5.8 1.82
43 INT354979 Positive_regulation of Localization of Cacna1a 2 0.05 0.86 1.79
44 INT355239 Negative_regulation of Positive_regulation of Cacna1a 1 0.04 0 1.79
45 INT71327 Localization of Cacna1a 3 0.60 2.51 1.7
46 INT143807 Negative_regulation of Abcc2 4 0.58 0.93 1.65
47 INT107299 Transcription of Fasl 6 0.68 5 1.64
48 INT147157 Positive_regulation of Abcc2 2 0.39 0.85 1.64
49 INT206471 Positive_regulation of Ptk2 34 0.51 25.75 1.61
50 INT93394 Positive_regulation of Transcription of Faslg 1 0.24 3.57 1.57
51 INT161379 Localization of Fasl 8 0.67 11.05 1.56
52 INT120288 Regulation of Gene_expression of Abcc2 5 0.44 1.3 1.52
53 INT137819 Binding of Faslg 3 0.09 1.78 1.51
54 INT110555 Localization of Abcc2 1 0.69 0 1.47
55 INT110556 Negative_regulation of Localization of Abcc2 1 0.39 0 1.47
56 INT355242 Negative_regulation of Binding of Cacna1a 1 0.04 0.17 1.47
57 INT88015 Positive_regulation of Faslg 5 0.65 5.73 1.44
58 INT355245 Regulation of Localization of Cacna1a 1 0.04 0 1.43
59 INT165690 Localization of Abcc2 4 0.79 1.31 1.38
60 INT90740 Negative_regulation of Cacna1a 3 0.23 1.43 1.38
61 INT131115 Regulation of Phosphorylation of Ptk2 2 0.61 0.3 1.34
62 INT135551 Positive_regulation of Gene_expression of FASLG 2 0.67 6.71 1.26
63 INT82727 Positive_regulation of Transcription of Cacna1a 1 0.01 1.07 1.25
64 INT135803 Regulation of Gene_expression of Fasl 6 0.36 4.35 1.24
65 INT130774 Transcription of FASLG 5 0.67 2.02 1.22
66 INT85571 Positive_regulation of Cacna1a 3 0.50 2.06 1.18
67 INT134506 Negative_regulation of Abcc2 2 0.41 0.06 1.17
68 INT355243 Negative_regulation of Regulation of Cacna1a 1 0.04 0 1.16
69 INT124317 Regulation of Gene_expression of FASLG 2 0.23 1.54 1.1
70 INT188407 Positive_regulation of Binding of Fasl 1 0.48 3.67 1.08
71 INT120287 Regulation of Abcc2 2 0.24 0.81 1.06
72 INT145443 Positive_regulation of Positive_regulation of Abcc2 1 0.07 0.93 1.06
73 INT321650 Negative_regulation of Gene_expression of Cacna1a 2 0.04 0.13 0.95
74 INT130299 Gene_expression of Abcc2 2 0.58 0.61 0.95
75 INT158436 Transcription of Abcc2 4 0.47 0.15 0.94
76 INT99941 Negative_regulation of Positive_regulation of Fasl 3 0.44 2.24 0.93
77 INT94046 Protein_catabolism of Cacna1a 1 0.70 0.83 0.9
78 INT130770 Positive_regulation of Transcription of FASLG 1 0.22 0.68 0.87
79 INT131964 Positive_regulation of CACNA1A 5 0.61 0.73 0.85
80 INT131113 Negative_regulation of Ptk2 3 0.58 0.17 0.85
81 INT86852 Regulation of Faslg 3 0.42 1.67 0.79
82 INT134207 Gene_expression of Ptk2 56 0.73 31.97 0.78
83 INT134505 Positive_regulation of Gene_expression of Abcc2 4 0.69 1.81 0.71
84 INT103336 Transcription of Cacna1a 2 0.69 1.17 0.68
85 INT141227 Phosphorylation of CACNA1A 1 0.55 0.78 0.66
86 INT95135 Negative_regulation of Gene_expression of FASLG 4 0.20 2.99 0.64
87 INT354814 Positive_regulation of Localization of Fasl 3 0.29 3.61 0.64
88 INT189813 Negative_regulation of CACNA1A 4 0.57 3.07 0.55
89 INT122930 Positive_regulation of Gene_expression of CACNA1A 2 0.49 0.91 0.54
90 INT134208 Negative_regulation of Ptk2 19 0.58 23.59 0.52
91 INT188405 Positive_regulation of Positive_regulation of Fasl 4 0.64 3.54 0.48
92 INT117772 Binding of Ptk2 1 0.37 0.17 0.46
93 INT130304 Positive_regulation of Gene_expression of Abcc2 1 0.38 0.21 0.46
94 INT323752 Negative_regulation of FASLG 2 0.18 2.36 0.43
95 INT271521 Phosphorylation of Ptk2 10 0.59 11.45 0.39
96 INT88021 Regulation of Gene_expression of Faslg 4 0.60 2.6 0.38
97 INT95132 Negative_regulation of Binding of FASLG 1 0.18 0.63 0.38
98 INT99962 Positive_regulation of Gene_expression of Cacna1a 1 0.01 1.1 0.34
99 INT155753 Regulation of Gene_expression of CACNA1A 1 0.27 0.66 0.32
100 INT83594 Negative_regulation of Phosphorylation of Ptk2 5 0.42 1.62 0.29
101 INT135805 Positive_regulation of Negative_regulation of Fasl 1 0.48 0.24 0.27
102 INT271522 Negative_regulation of Phosphorylation of Ptk2 3 0.19 2.09 0.26
103 INT143806 Positive_regulation of Negative_regulation of Abcc2 1 0.49 0 0.25
104 INT308545 Gene_expression of Tbxas1 1 0.02 0.76 0.25
105 INT88018 Positive_regulation of Positive_regulation of Faslg 1 0.47 0.75 0.23
106 INT308522 Positive_regulation of Positive_regulation of Ptk2 2 0.22 2.37 0.21
107 INT94547 Localization of Faslg 1 0.76 0.71 0.21
108 INT355529 Negative_regulation of Transcription of Fasl 1 0.26 1.23 0.2
109 INT283561 Regulation of Gene_expression of Ptk2 5 0.42 1.1 0.17
110 INT85327 Negative_regulation of Tbxas1 1 0.06 0.67 0.16
111 INT83595 Negative_regulation of Gene_expression of Ptk2 1 0.23 1.62 0.14
112 INT131114 Positive_regulation of Gene_expression of Ptk2 1 0.49 0.27 0.14
113 INT327399 Negative_regulation of Positive_regulation of Ptk2 7 0.43 4.75 0.13
114 INT269240 Regulation of Ptk2 6 0.42 2.84 0.13
115 INT347940 Regulation of Positive_regulation of Fasl 1 0.30 1.95 0.13
116 INT283567 Regulation of Regulation of Ptk2 1 0.42 0.3 0.13
117 INT307073 Binding of Tbxas1 1 0.01 1.35 0.12
118 INT283560 Negative_regulation of Gene_expression of Ptk2 6 0.40 4.84 0.09
119 INT271523 Positive_regulation of Gene_expression of Ptk2 6 0.65 8 0.08
120 INT274227 Negative_regulation of Binding of Fasl 2 0.37 1.96 0.08
121 INT196235 Negative_regulation of Transcription of CACNA1A 1 0.36 0.1 0.07
122 INT196229 Transcription of CACNA1A 1 0.60 0.24 0.07
123 INT250476 Negative_regulation of Transcription of FASLG 1 0.22 0.76 0.06
124 INT333217 Regulation of Positive_regulation of Ptk2 1 0.12 0.36 0.05
125 INT309389 Phosphorylation of Cacna1a 1 0.01 0.54 0.05
126 INT309386 Positive_regulation of Phosphorylation of Cacna1a 1 0.01 0.54 0.05
127 INT354783 Positive_regulation of Regulation of Fasl 1 0.20 1.49 0.05
128 INT238180 Binding of Ptk2 5 0.35 2.99 0.04
129 INT327396 Positive_regulation of Negative_regulation of Ptk2 1 0.37 0.95 0.04
130 INT295374 Positive_regulation of Ptk2 1 0.34 0.06 0.04
131 INT283566 Localization of Ptk2 5 0.75 0.93 0
132 INT86883 Regulation of Tbxas1 2 0.01 3 0
133 INT210195 Regulation of Transcription of FASLG 1 0.08 0 0
134 INT283564 Positive_regulation of Localization of Ptk2 1 0.47 0 0
135 INT295392 Positive_regulation of Localization of Ptk2 1 0.37 0 0
136 INT351934 Regulation of Binding of Fasl 1 0.36 1.83 0
137 INT351669 Negative_regulation of Binding of Ptk2 1 0.40 0.73 0
138 INT168333 Negative_regulation of Transcription of Abcc2 1 0.39 0.06 0
139 INT196237 Positive_regulation of Transcription of CACNA1A 1 0.39 0.14 0
140 INT295387 Localization of Ptk2 1 0.55 0 0
141 INT206472 Transcription of Ptk2 1 0.52 0.46 0
142 INT238159 Regulation of Binding of Ptk2 1 0.03 0.06 0
143 INT101130 Protein_catabolism of Fasl 1 0.42 0.29 0
144 INT168334 Regulation of Transcription of Abcc2 1 0.30 0.09 0
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