GO:0030695

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Name GTPase regulator activity
Categary Function
Go Slim No
Go Link GO:0030695
Unique Molecular Interactions 46
Total Molecular Interactions 58
Total Single Events 417
Pain Genes Associated 6

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for GTPase regulator activity. They are ordered first by their pain relevance and then by number of times they were reported for GTPase regulator activity. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT146352 Binding of Rgs14 and Mors1 1 0.23 0.27 1.17
2 INT130932 Negative_regulation of Cpox Positive_regulation of Gene_expression of TSC1 1 0.00 0.42 0.18
3 INT252901 PTTG1 Regulation of Gene_expression of TSC1 1 0.00 1.61 0.13
4 INT74014 Binding of TSC1 and XRCC1 1 0.02 1.98 0.09
5 INT276304 PRDM1 Regulation of TSC1 1 0.01 1.29 0.09
6 INT276391 Prdm1 Regulation of TSC1 1 0.00 1.29 0.09
7 INT272012 Binding of TSC1 and Lsamp 1 0.03 2.1 0.08
8 INT272003 Binding of Tsc2 and Tsc1 1 0.18 1.1 0.07
9 INT246793 Binding of Tsc2 and Tsc1 1 0.04 0.71 0.04
10 INT302159 TSC1 Positive_regulation of Transcription of CDKN1A 1 0.00 0.28 0.03
11 INT272009 Binding of YWHAQ and Tsc1 1 0.37 0.14 0.03
12 INT341537 F2RL1 Positive_regulation of TSC1 1 0.01 0.76 0.03
13 INT314401 Binding of Ctbs and Gpsm2 1 0.10 0 0
14 INT314395 Binding of Gpsm2 and Slc17a6 1 0.20 0 0
15 INT356237 Binding of CLTC and GPSM2 1 0.00 0 0
16 INT246808 Tsc2 Regulation of Regulation of Tsc1 1 0.02 0.05 0
17 INT271990 Tsc1 Positive_regulation of Tsc2 1 0.36 0.31 0
18 INT272018 Binding of TSC1 and Tsc2 1 0.17 0.48 0
19 INT331222 Tsc1 Negative_regulation of Mtor 1 0.00 0.68 0
20 INT271996 Binding of Plk1 and Tsc1 1 0.09 0.32 0
21 INT297614 ZNF275 Positive_regulation of Gene_expression of TSC1 1 0.00 1.56 0
22 INT271991 Tsc1 Regulation of Tsc2 1 0.23 0.15 0
23 INT272015 Pkd1 Positive_regulation of Localization of TSC1 1 0.18 0.65 0
24 INT272017 TBC1D7 Positive_regulation of Protein_catabolism of Tsc1 1 0.08 0.46 0
25 INT314403 Ptpn6 Positive_regulation of Gpsm2 1 0.12 0.07 0
26 INT297613 Negative_regulation of ZNF275 Positive_regulation of Gene_expression of TSC1 1 0.00 1.66 0
27 INT259093 Binding of TSC1 and LMO4 1 0.02 0.74 0
28 INT217786 TSC1 Regulation of MITF 1 0.00 1.27 0
29 INT351157 TSC1 Positive_regulation of Gene_expression of CAV1 1 0.01 1.43 0
30 INT271985 Tsc1 Regulation of Cdkn1b 1 0.04 0.1 0
31 INT259092 TSC1 Positive_regulation of Gene_expression of TCEAL1 1 0.01 4.58 0
32 INT268596 Mir10a Regulation of TSC1 1 0.01 0.44 0
33 INT272008 Tsc1 Negative_regulation of Binding of HERC1 1 0.01 0.32 0
34 INT297615 Binding of TSC1 and HDAC9 1 0.01 0.4 0
35 INT300337 Gene_expression of MITF Negative_regulation of Gene_expression of TSC1 1 0.00 0.65 0
36 INT217784 Binding of MITF and TSC1 1 0.00 1.21 0
37 INT272014 Binding of RB1CC1 and Tsc1 1 0.05 0.44 0
38 INT331223 Negative_regulation of Tsc1 Positive_regulation of Positive_regulation of Mtor 1 0.01 0.33 0
39 INT217774 TP53 Regulation of TSC1 1 0.02 1.28 0
40 INT314400 Binding of Ptpn6 and Gpsm2 1 0.07 0 0
41 INT217791 TP53 Positive_regulation of TSC1 1 0.04 0.61 0
42 INT300631 Binding of TSC1 and TSC2 1 0.15 2.59 0
43 INT271998 Cdk1 Positive_regulation of Phosphorylation of Tsc1 1 0.17 0.3 0
44 INT268509 MIR146B Regulation of TSC1 1 0.03 0.44 0
45 INT271986 Tsc1 Regulation of Skp2 1 0.13 0.14 0
46 INT331221 Binding of Akt1 and Tsc1 1 0.03 0.33 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for GTPase regulator activity. They are ordered first by their pain relevance and then by number of times they were reported in GTPase regulator activity. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT53487 Gene_expression of TSC1 81 0.58 77.71 7.94
2 INT146350 Phosphorylation of Rgs14 1 0.80 0.79 3.77
3 INT73463 Positive_regulation of Gene_expression of TSC1 20 0.38 14.59 3.53
4 INT112372 Positive_regulation of GPSM2 8 0.41 5.49 1.94
5 INT56925 Negative_regulation of TSC1 54 0.52 63.39 1.87
6 INT181266 Gene_expression of GPSM2 18 0.32 0.54 1.64
7 INT126276 Regulation of Rgs14 1 0.39 0.71 1.63
8 INT268009 Gene_expression of Gpsm2 12 0.54 0.23 1.34
9 INT214073 Binding of TSC1 9 0.37 22 1.34
10 INT146351 Positive_regulation of Phosphorylation of Rgs14 1 0.45 0.27 1.23
11 INT275292 Positive_regulation of Gpsm2 7 0.55 0.33 1.19
12 INT126279 Gene_expression of Rgs14 1 0.67 0.34 0.98
13 INT73465 Transcription of TSC1 4 0.07 3.47 0.96
14 INT74019 Regulation of TSC1 27 0.35 23.61 0.79
15 INT112373 Negative_regulation of Positive_regulation of GPSM2 1 0.38 1.87 0.73
16 INT285478 Negative_regulation of Rgs14 1 0.27 1.25 0.6
17 INT271939 Regulation of Tsc1 2 0.41 1.16 0.47
18 INT224164 Binding of GPSM2 5 0.17 1.14 0.46
19 INT175423 Positive_regulation of TSC1 25 0.36 21.81 0.45
20 INT181268 Localization of GPSM2 3 0.35 2.49 0.44
21 INT289642 Negative_regulation of Gene_expression of GPSM2 1 0.13 0 0.36
22 INT209419 Regulation of GPSM2 5 0.21 3.03 0.33
23 INT184803 Localization of TSC1 5 0.37 6.13 0.32
24 INT286265 Negative_regulation of GPSM2 3 0.20 1.06 0.31
25 INT256540 Regulation of Gene_expression of TSC1 4 0.07 4.74 0.3
26 INT322756 Negative_regulation of Tsc1 1 0.07 1.4 0.26
27 INT217832 Negative_regulation of Gene_expression of TSC1 5 0.04 5.45 0.21
28 INT268008 Localization of Gpsm2 2 0.60 0.16 0.2
29 INT181270 Protein_catabolism of GPSM2 1 0.31 0.42 0.19
30 INT275291 Regulation of Gpsm2 3 0.36 0.43 0.17
31 INT314390 Positive_regulation of Gene_expression of Gpsm2 1 0.40 0 0.12
32 INT181265 Positive_regulation of Gene_expression of GPSM2 2 0.24 0.19 0.11
33 INT173222 Negative_regulation of Negative_regulation of TSC1 1 0.01 0.92 0.09
34 INT190703 Regulation of Negative_regulation of TSC1 3 0.06 3.08 0.07
35 INT271938 Binding of Tsc1 1 0.43 3.18 0.07
36 INT348907 Negative_regulation of Gpsm2 1 0.18 0 0.05
37 INT271914 Negative_regulation of Tsc1 5 0.38 3.08 0.04
38 INT314389 Transcription of Gpsm2 1 0.55 0 0.04
39 INT271930 Gene_expression of Tsc1 1 0.69 6.88 0.04
40 INT246758 Gene_expression of Tsc1 1 0.11 0.55 0.04
41 INT190057 Positive_regulation of Negative_regulation of TSC1 2 0.01 1.08 0.03
42 INT271960 Positive_regulation of Binding of TSC1 1 0.25 0.88 0.03
43 INT190054 Negative_regulation of Positive_regulation of TSC1 1 0.01 0.83 0.03
44 INT275290 Negative_regulation of Regulation of Gpsm2 1 0.03 0.15 0.03
45 INT271936 Phosphorylation of Tsc1 4 0.73 1.76 0
46 INT175424 Regulation of Transcription of TSC1 2 0.05 1.39 0
47 INT271963 Phosphorylation of TSC1 2 0.31 2.02 0
48 INT314391 Negative_regulation of Positive_regulation of Gpsm2 1 0.34 0.12 0
49 INT271965 Negative_regulation of Binding of TSC1 1 0.33 0.44 0
50 INT246748 Regulation of Tsc1 1 0.04 0.05 0
51 INT246773 Phosphorylation of Tsc1 1 0.13 0.05 0
52 INT356247 Positive_regulation of Regulation of GPSM2 1 0.03 0 0
53 INT271913 Protein_catabolism of Tsc1 1 0.51 0.45 0
54 INT271906 Negative_regulation of Binding of Tsc1 1 0.38 0.06 0
55 INT271927 Positive_regulation of Tsc1 1 0.44 0.4 0
56 INT314387 Positive_regulation of Regulation of Gpsm2 1 0.40 0.12 0
57 INT271931 Negative_regulation of Gene_expression of Tsc1 1 0.38 0.44 0
58 INT314386 Positive_regulation of Positive_regulation of Gpsm2 1 0.40 0 0
59 INT356248 Regulation of Gene_expression of GPSM2 1 0.02 0 0
60 INT322758 Positive_regulation of Localization of TSC1 1 0.06 1.4 0
61 INT331195 Positive_regulation of Negative_regulation of Tsc1 1 0.18 0.15 0
62 INT212406 Binding of Gpsm2 1 0.01 0.23 0
63 INT246757 Binding of Tsc1 1 0.06 0.19 0
64 INT181271 Regulation of Localization of GPSM2 1 0.21 0.19 0
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