GO:0030742

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Name GTP-dependent protein binding
Categary Function
Go Slim No
Go Link GO:0030742
Unique Molecular Interactions 59
Total Molecular Interactions 107
Total Single Events 936
Pain Genes Associated 11

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for GTP-dependent protein binding. They are ordered first by their pain relevance and then by number of times they were reported for GTP-dependent protein binding. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT324068 Binding of GCH1 and SNRNP70 1 0.01 28.19 40.6
2 INT324067 Regulation of Binding of GCH1 and SNRNP70 1 0.01 0.95 1.67
3 INT236491 GCH1 Regulation of Pain1 1 0.01 0.89 1.65
4 INT284785 Gch1 Regulation of Bh4p 1 0.00 1.48 1.54
5 INT135830 Gch1 Regulation of Nos2 1 0.65 0 1.29
6 INT116730 Rac1 Regulation of Localization of Calca 1 0.13 1.32 1.19
7 INT53152 Rac1 Regulation of Scg2 1 0.03 0 0.9
8 INT53155 Rac1 Positive_regulation of Gene_expression of Calca 1 0.06 0 0.89
9 INT43662 Negative_regulation of Binding of Chrna7 and Rac1 1 0.01 0 0.73
10 INT43661 Binding of Chrna7 and Rac1 1 0.01 0 0.72
11 INT330104 Binding of Sh3rf1 and Rac1 1 0.13 2.41 0.62
12 INT330101 Binding of Map3k11 and Rac1 1 0.16 2.43 0.62
13 INT97949 Negative_regulation of NRP2 Negative_regulation of Positive_regulation of CDC42 1 0.06 0.72 0.51
14 INT97953 ST3GAL3 Positive_regulation of CDC42 1 0.09 0.7 0.5
15 INT131508 Gene_expression of Rac1 Positive_regulation of Trpv1 1 0.42 0.21 0.48
16 INT131503 Gene_expression of Rac1 Positive_regulation of Ngf 1 0.38 0.21 0.48
17 INT148930 Rac1 Regulation of Chrna7 1 0.13 0.6 0.44
18 INT131506 Rac1 Regulation of Positive_regulation of Mapk14 1 0.19 0.39 0.42
19 INT131505 Rac1 Regulation of Gene_expression of Trpv1 1 0.55 0.39 0.42
20 INT275156 Agt Positive_regulation of Rac1 1 0.03 2.89 0.4
21 INT291625 Binding of CSTA and RAPGEF5 1 0.03 4.81 0.37
22 INT26552 Gene_expression of Mras Positive_regulation of Gene_expression of KNG1 1 0.03 0.07 0.36
23 INT330105 Rac1 Positive_regulation of Mapk8 1 0.15 1.47 0.34
24 INT241742 Negative_regulation of Sdhb Regulation of Rapgef5 1 0.02 0.39 0.33
25 INT330103 Rac1 Positive_regulation of Positive_regulation of Mapk8 1 0.14 1.24 0.32
26 INT330109 Binding of Racgap1 and Rac1 1 0.03 1.22 0.32
27 INT241740 Sdhb Regulation of Rapgef5 1 0.02 0.34 0.32
28 INT285567 Binding of IL1B and Cdc42 1 0.03 0.77 0.31
29 INT292565 MAP3K5 Positive_regulation of Positive_regulation of CDC42 1 0.02 0 0.23
30 INT143973 Rac1 Positive_regulation of Vti1b 1 0.00 0.16 0.2
31 INT172976 Mras Regulation of Gene_expression of Smad4 1 0.00 0.83 0.12
32 INT287267 EGF Positive_regulation of CDC42 1 0.12 0.16 0.11
33 INT275157 Binding of Stat3 and Rac1 1 0.05 0.71 0.1
34 INT275158 Rac1 Positive_regulation of Stat3 1 0.07 0.72 0.1
35 INT171709 Rac1 Negative_regulation of Localization of Chrna7 1 0.04 0.75 0.08
36 INT302632 Rac1 Positive_regulation of Gene_expression of Rhog 1 0.37 0.21 0.05
37 INT181083 Binding of Akt1 and Cdc42 1 0.00 0.79 0.03
38 INT291621 RAPGEF5 Regulation of CSTA 1 0.04 0.43 0.03
39 INT288829 Binding of Rhoa and Rac1 2 0.21 1.88 0
40 INT302640 Rac1 Regulation of Gene_expression of VEGFA 1 0.03 0 0
41 INT280568 MRAS Positive_regulation of RAF1 1 0.01 0.7 0
42 INT115368 Binding of GDNF and RAPGEF5 1 0.32 0 0
43 INT345287 Binding of SCN10A and RAPGEF5 1 0.01 0.67 0
44 INT302641 Rac1 Regulation of TIE1 1 0.25 0.47 0
45 INT234996 Ctnnd1 Positive_regulation of CDC42 1 0.01 0.07 0
46 INT263248 Binding of ADD1 and RAPGEF5 1 0.01 0.84 0
47 INT254847 Rac1 Positive_regulation of Fbrs 1 0.09 0.81 0
48 INT228112 Gene_expression of Chrm2 Positive_regulation of Positive_regulation of Rac1 1 0.14 0.26 0
49 INT288826 Binding of Rac1 and Vav1 1 0.25 0.68 0
50 INT334474 PGGT1B Regulation of Localization of Rac1 1 0.03 0.47 0
51 INT249149 Binding of Cdc42 and Was 1 0.08 0.18 0
52 INT302634 Rac1 Regulation of Gene_expression of Kdr 1 0.36 0 0
53 INT302633 Rac1 Regulation of Cdc42ep2 1 0.01 0 0
54 INT334468 Rhoa Regulation of Localization of Rac1 1 0.25 0.18 0
55 INT254853 Rhoa Positive_regulation of Rac1 1 0.10 0.81 0
56 INT257340 Binding of Cyba and Rac1 1 0.09 0.29 0
57 INT254850 Setd1a Negative_regulation of Rac1 1 0.00 0 0
58 INT181085 Binding of Cdc42 and Errfi1 1 0.08 0.67 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for GTP-dependent protein binding. They are ordered first by their pain relevance and then by number of times they were reported in GTP-dependent protein binding. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT19396 Regulation of Rac1 66 0.53 37.41 30.01
2 INT47459 Gene_expression of Rac1 101 0.68 45.27 24.33
3 INT150934 Gene_expression of GCH1 17 0.78 14.54 17.53
4 INT23212 Positive_regulation of Rac1 46 0.55 32.85 15.1
5 INT27627 Binding of Rac1 41 0.41 22.88 13.68
6 INT139443 Positive_regulation of GCH1 9 0.69 8.2 10.14
7 INT50055 Negative_regulation of Rac1 36 0.50 19.74 8.98
8 INT152347 Binding of GCH1 8 0.37 6.13 7.36
9 INT163776 Regulation of GCH1 7 0.27 4.58 6.16
10 INT4679 Negative_regulation of RAPGEF5 55 0.57 47.51 4.55
11 INT106422 Negative_regulation of Gene_expression of Rac1 4 0.43 3.97 3.41
12 INT135815 Transcription of Gch1 1 0.60 0 3.32
13 INT58475 Localization of Rac1 12 0.75 5.94 3.2
14 INT150933 Negative_regulation of Positive_regulation of GCH1 3 0.58 1.8 2.77
15 INT150932 Positive_regulation of Gene_expression of GCH1 3 0.70 2.07 2.57
16 INT65928 Positive_regulation of Gene_expression of Rac1 12 0.42 3.34 2.33
17 INT283973 Transcription of GCH1 1 0.61 1.99 2.33
18 INT283975 Negative_regulation of Localization of GCH1 1 0.38 1.99 2.27
19 INT135827 Positive_regulation of Transcription of Gch1 1 0.58 0 2.2
20 INT258637 Regulation of Gene_expression of GCH1 1 0.62 1.77 2.02
21 INT117980 Regulation of Rac1 10 0.45 3.72 1.88
22 INT135820 Regulation of Gch1 1 0.59 0 1.88
23 INT37485 Regulation of RAPGEF5 10 0.44 6.64 1.51
24 INT47734 Positive_regulation of RAPGEF5 19 0.56 13.16 1.41
25 INT135822 Gene_expression of Gch1 2 0.50 0.77 1.35
26 INT16013 Gene_expression of Rac1 52 0.75 23.79 1.21
27 INT98062 Regulation of Gene_expression of Rac1 4 0.39 1.41 1.21
28 INT97955 Positive_regulation of CDC42 8 0.49 2.47 1.19
29 INT122891 Negative_regulation of Gch1 4 0.16 1.83 1.15
30 INT98061 Negative_regulation of Binding of Rac1 3 0.43 2.28 1.13
31 INT283974 Negative_regulation of Transcription of GCH1 1 0.38 0.99 1.13
32 INT283972 Localization of GCH1 1 0.67 0.99 1.13
33 INT283976 Positive_regulation of Binding of GCH1 1 0.45 1.27 1.13
34 INT150931 Negative_regulation of GCH1 6 0.59 1.23 1.05
35 INT188774 Binding of RAPGEF5 12 0.29 13.55 1.04
36 INT67174 Negative_regulation of Rac1 22 0.56 10.72 0.99
37 INT4681 Localization of RAPGEF5 12 0.68 8.69 0.93
38 INT161682 Positive_regulation of Cdc42 8 0.53 4.55 0.9
39 INT81211 Transcription of Rac1 4 0.54 1.05 0.89
40 INT330097 Positive_regulation of Positive_regulation of Rac1 1 0.37 2.47 0.86
41 INT241722 Gene_expression of Rapgef5 1 0.24 1.34 0.81
42 INT264629 Localization of Rac1 8 0.72 5.7 0.79
43 INT115596 Regulation of Regulation of Rac1 1 0.36 0.29 0.7
44 INT180107 Regulation of Cdc42 3 0.16 0.18 0.6
45 INT228103 Positive_regulation of Rac1 25 0.67 18.92 0.57
46 INT97956 Negative_regulation of CDC42 3 0.27 1.58 0.55
47 INT16012 Binding of Rac1 17 0.37 6.9 0.53
48 INT26548 Gene_expression of Mras 2 0.19 0.48 0.48
49 INT81212 Negative_regulation of Transcription of Rac1 1 0.01 0 0.46
50 INT11118 Gene_expression of RAPGEF5 13 0.65 9.35 0.43
51 INT87847 Regulation of Positive_regulation of Rac1 2 0.36 1.49 0.43
52 INT26547 Positive_regulation of Gene_expression of Mras 1 0.03 0.07 0.36
53 INT124986 Positive_regulation of Localization of Rac1 3 0.50 1.22 0.33
54 INT112551 Protein_catabolism of Rac1 2 0.66 0.29 0.3
55 INT116729 Regulation of Localization of Rac1 1 0.01 0.07 0.29
56 INT99682 Phosphorylation of Rac1 1 0.54 0.72 0.28
57 INT325209 Localization of Gch1 1 0.25 0.72 0.28
58 INT325214 Positive_regulation of Localization of Gch1 1 0.17 0.73 0.28
59 INT325216 Positive_regulation of Gch1 2 0.23 1.5 0.27
60 INT325218 Negative_regulation of Positive_regulation of Gch1 2 0.14 1.51 0.27
61 INT270743 Negative_regulation of Localization of RAPGEF5 1 0.11 1.6 0.27
62 INT162873 Negative_regulation of Negative_regulation of Rac1 1 0.34 0.35 0.26
63 INT330090 Regulation of Negative_regulation of Rac1 1 0.36 0.53 0.25
64 INT183881 Localization of CDC42 3 0.49 1.92 0.23
65 INT330093 Negative_regulation of Positive_regulation of Rac1 1 0.34 0.88 0.23
66 INT183876 Regulation of CDC42 3 0.30 1.94 0.19
67 INT325205 Positive_regulation of Gene_expression of Gch1 1 0.17 0.77 0.19
68 INT168055 Regulation of Transcription of Rac1 1 0.36 0.34 0.16
69 INT197290 Gene_expression of Cdc42 9 0.35 2.52 0.15
70 INT133599 Positive_regulation of Binding of Rac1 2 0.40 0.4 0.15
71 INT330085 Regulation of Binding of Rac1 1 0.36 0.28 0.15
72 INT60344 Regulation of Gene_expression of Mras 1 0.15 0.41 0.13
73 INT206133 Binding of CDC42 3 0.25 0.8 0.12
74 INT279950 Positive_regulation of Positive_regulation of RAPGEF5 1 0.24 1.56 0.1
75 INT293085 Regulation of Rapgef5 1 0.26 0.31 0.09
76 INT302613 Positive_regulation of Gene_expression of Rac1 14 0.67 3.7 0.08
77 INT197282 Positive_regulation of Gene_expression of Cdc42 3 0.26 0.12 0.08
78 INT164479 Positive_regulation of Gene_expression of RAPGEF5 2 0.49 1.3 0.08
79 INT334443 Positive_regulation of Positive_regulation of Rac1 1 0.33 1.1 0.08
80 INT4680 Positive_regulation of Negative_regulation of RAPGEF5 2 0.45 1.66 0.07
81 INT302624 Negative_regulation of Gene_expression of Rac1 1 0.56 3.67 0.06
82 INT11119 Negative_regulation of Gene_expression of RAPGEF5 1 0.41 0.89 0.06
83 INT206169 Gene_expression of CDC42 2 0.26 1.05 0.05
84 INT206167 Positive_regulation of Gene_expression of CDC42 1 0.08 0.05 0.05
85 INT323949 Negative_regulation of Positive_regulation of Rac1 1 0.23 0.53 0.05
86 INT241736 Negative_regulation of Rapgef5 2 0.57 1 0.04
87 INT334445 Regulation of Positive_regulation of Rac1 1 0.40 1.73 0.04
88 INT302611 Regulation of Gene_expression of Rac1 1 0.43 4.5 0.03
89 INT302615 Transcription of Rac1 5 0.66 1.1 0
90 INT254795 Negative_regulation of Cdc42 2 0.12 1.53 0
91 INT334450 Regulation of Localization of Rac1 1 0.30 0.65 0
92 INT228095 Phosphorylation of Rac1 1 0.34 0.21 0
93 INT302609 Positive_regulation of Transcription of Rac1 1 0.48 0.27 0
94 INT270614 Localization of Cdc42 1 0.55 0.95 0
95 INT354543 Regulation of Gene_expression of RAPGEF5 1 0.03 0.82 0
96 INT302631 Regulation of Transcription of Rac1 1 0.43 0.47 0
97 INT197294 Regulation of Gene_expression of Cdc42 1 0.13 0 0
98 INT175588 Regulation of MRAS 1 0.02 1.64 0
99 INT188966 Regulation of Positive_regulation of RAPGEF5 1 0.36 0.38 0
100 INT302621 Regulation of Negative_regulation of Rac1 1 0.43 0 0
101 INT302627 Negative_regulation of Localization of Rac1 1 0.41 0.28 0
102 INT282269 Binding of Cdc42 1 0.08 0.33 0
103 INT302620 Negative_regulation of Transcription of Rac1 1 0.41 0 0
104 INT287281 Positive_regulation of Positive_regulation of CDC42 1 0.26 0 0
105 INT279951 Negative_regulation of Negative_regulation of RAPGEF5 1 0.18 2.57 0
106 INT282272 Positive_regulation of Binding of Cdc42 1 0.11 0.33 0
107 INT334438 Positive_regulation of Localization of Rac1 1 0.33 2.37 0
108 INT293086 Positive_regulation of Rapgef5 1 0.67 0.33 0
109 INT270739 Negative_regulation of Positive_regulation of RAPGEF5 1 0.04 0.36 0
110 INT210067 Protein_catabolism of RAPGEF5 1 0.05 0.24 0
111 INT163775 Negative_regulation of Regulation of GCH1 1 0.43 0 0
112 INT178512 Positive_regulation of MRAS 1 0.01 0.99 0
113 INT198960 Transcription of RAPGEF5 1 0.07 1.59 0
114 INT254786 Positive_regulation of Negative_regulation of Rac1 1 0.26 0.95 0
115 INT302614 Positive_regulation of Binding of Rac1 1 0.48 0.31 0
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