GO:0030816

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Name positive regulation of cAMP metabolic process
Categary Process
Go Slim No
Go Link GO:0030816
Unique Molecular Interactions 112
Total Molecular Interactions 267
Total Single Events 867
Pain Genes Associated 6

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for positive regulation of cAMP metabolic process. They are ordered first by their pain relevance and then by number of times they were reported for positive regulation of cAMP metabolic process. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT16531 Ghrh Positive_regulation of Localization of Gh1 31 0.64 2.12 14.2
2 INT26468 Ghrh Positive_regulation of Localization of Gh 21 0.37 3.26 9.21
3 INT10844 Ghrh Regulation of Gh 13 0.13 4.77 4.71
4 INT16221 Ghrh Positive_regulation of Gh 8 0.21 1.89 4.08
5 INT11248 Gh Positive_regulation of Ghrh 2 0.26 0.09 4.04
6 INT20411 Ghrh Positive_regulation of Gh1 6 0.56 0.62 2.47
7 INT7367 Ghrh Regulation of Localization of Gh1 5 0.49 1.55 2.25
8 INT18197 Ghrh Positive_regulation of Localization of Ggh 4 0.46 0 2.23
9 INT9180 Ghrh Regulation of Localization of Gh 3 0.24 0.25 2.18
10 INT120319 Ghrh Regulation of Ngf 1 0.25 1.89 2.11
11 INT35502 Ghrh Positive_regulation of Localization of Gnrhr 7 0.57 0.18 2
12 INT32482 Ghrh Positive_regulation of Prl 3 0.18 0.26 1.62
13 INT34834 Ghrh Positive_regulation of Gene_expression of Gh1 2 0.65 0 1.4
14 INT152428 Ghrh Positive_regulation of Pde6b 1 0.07 0.5 1.18
15 INT32480 Gh1 Positive_regulation of Gene_expression of Ghrh 1 0.35 0 1.15
16 INT5106 Gal Positive_regulation of Localization of Ghrh 1 0.21 0 1.07
17 INT120317 Ghrh Regulation of Positive_regulation of Ngf 1 0.25 0.95 1.06
18 INT120311 Ghrh Regulation of Gene_expression of Ngf 1 0.25 0.95 1.06
19 INT120312 Ghrh Regulation of Tnf 1 0.26 0.95 1.05
20 INT120316 Ghrh Regulation of Il6 1 0.11 0.95 1.05
21 INT120314 Ghrh Regulation of Positive_regulation of Tnf 1 0.43 0.95 1.05
22 INT120310 Ghrh Regulation of Positive_regulation of Il6 1 0.18 0.95 1.05
23 INT19758 Ghrh Positive_regulation of Positive_regulation of Gh 1 0.26 0 0.98
24 INT25272 Binding of Ggh and Ghrh 1 0.22 0 0.97
25 INT5108 Gal Positive_regulation of Ghrh 1 0.21 0 0.96
26 INT31108 Ghrh Negative_regulation of Gh1 2 0.55 0 0.95
27 INT295530 Ghrl Regulation of Gene_expression of Ghrh 1 0.30 0.21 0.95
28 INT62106 Ghrh Negative_regulation of Localization of Gh 1 0.06 0 0.94
29 INT35252 Gene_expression of Ghrh Positive_regulation of Localization of Gh1 1 0.49 0 0.93
30 INT295547 Ghrl Regulation of Ghrh 1 0.30 0.06 0.9
31 INT30411 Ghrh Regulation of Gene_expression of Gh1 1 0.40 0.12 0.9
32 INT62111 SLC25A4 Negative_regulation of Regulation of Ghrh 1 0.41 0 0.9
33 INT15730 Ghrh Positive_regulation of Gnrhr 2 0.14 0.08 0.84
34 INT33995 Ghrh Regulation of Gnrhr 2 0.18 0.43 0.77
35 INT152429 Ghrh Positive_regulation of Localization of Gh 4 0.37 0.56 0.75
36 INT31306 Ghrh Regulation of Localization of Gnrhr 2 0.14 1 0.73
37 INT31307 Ghrh Regulation of Gh1 3 0.27 1.36 0.7
38 INT30125 Binding of Gh and Ghrh 2 0.06 0.36 0.7
39 INT290547 Pdyn Positive_regulation of Gpr3 1 0.21 0.42 0.7
40 INT290539 Positive_regulation of Pdyn Positive_regulation of Gpr3 1 0.21 0.42 0.7
41 INT290541 Gpr3 Positive_regulation of Phosphorylation of Oprk1 1 0.18 0.45 0.69
42 INT64070 Tp63 Regulation of Ghrh 1 0.04 0.06 0.69
43 INT5105 Gal Regulation of Localization of Ghrh 1 0.19 0 0.66
44 INT62249 Ghrh Regulation of Adrb1 1 0.00 0 0.62
45 INT19011 Binding of Ghrh and Ghsr 1 0.40 0 0.62
46 INT61507 Ghrhr Positive_regulation of Localization of Gh1 1 0.41 0 0.61
47 INT98815 Binding of Crhr2 and Ucn 3 0.32 0.5 0.56
48 INT69566 Positive_regulation of Ghrh Regulation of Gh 1 0.04 1.66 0.55
49 INT32478 Gh1 Regulation of Gene_expression of Ghrh 1 0.28 0 0.55
50 INT30959 Ghrh Positive_regulation of Localization of SST 1 0.01 0 0.54
51 INT56671 Negative_regulation of Ghrh Positive_regulation of Gh1 1 0.40 0 0.49
52 INT34988 Ghrh Positive_regulation of Calca 1 0.06 0 0.48
53 INT34990 Calca Positive_regulation of Ghrh 1 0.06 0 0.47
54 INT295548 Ghrl Regulation of Regulation of Ghrh 1 0.30 0 0.45
55 INT152430 Regulation of Ghrh Positive_regulation of Pde6b 1 0.04 0.16 0.43
56 INT250531 Ghrh Regulation of Gh 1 0.22 0 0.41
57 INT62107 Ghrh Negative_regulation of Regulation of Gh 1 0.06 0 0.39
58 INT67553 Ghrh Positive_regulation of Regulation of Gh 1 0.04 0.55 0.39
59 INT152431 Regulation of Ghrh Positive_regulation of Scn7a 1 0.02 0.17 0.38
60 INT152426 Ghrh Positive_regulation of Positive_regulation of Pde6b 1 0.07 0.14 0.38
61 INT152427 Ghrh Positive_regulation of Scn7a 1 0.03 0.17 0.38
62 INT34865 Ghrh Positive_regulation of Gene_expression of Gnrhr 1 0.07 0 0.37
63 INT84030 Regulation of Ghrh Positive_regulation of Gh 1 0.18 0 0.35
64 INT54930 Gnrhr Regulation of Gene_expression of Ghrh 1 0.10 0.16 0.34
65 INT295539 Gabrg1 Positive_regulation of Gene_expression of Ghrh 1 0.30 0 0.33
66 INT31042 Ghrh Positive_regulation of Localization of PLOD1 1 0.08 0 0.32
67 INT31040 Ghrh Positive_regulation of Localization of FSHR 1 0.05 0 0.31
68 INT31043 Ghrh Positive_regulation of PLOD1 1 0.03 0 0.31
69 INT31041 Ghrh Positive_regulation of FSHR 1 0.05 0 0.31
70 INT31036 Ghrh Regulation of Gnrh1 1 0.19 0 0.29
71 INT98816 Crhr2 Positive_regulation of Negative_regulation of Ucn 1 0.33 0.09 0.28
72 INT295531 Ghrl Negative_regulation of Gene_expression of Ghrh 1 0.25 0 0.27
73 INT20029 Ghrh Positive_regulation of Negative_regulation of Gh 1 0.05 0.14 0.26
74 INT295541 Ghrl Positive_regulation of Ghrh 1 0.31 0 0.26
75 INT68872 Ghrh Regulation of IGF1 1 0.09 0.18 0.26
76 INT295535 Gabrg1 Regulation of Ghrh 1 0.16 0.08 0.26
77 INT250536 Ghrh Positive_regulation of Negative_regulation of Ptpn6 1 0.09 0 0.24
78 INT50488 Vip Positive_regulation of Localization of Ghrh 1 0.60 0 0.24
79 INT215037 Ghrh Regulation of Localization of Igf2 1 0.04 2.12 0.24
80 INT20030 Negative_regulation of SST Positive_regulation of Ghrh 1 0.01 0.16 0.23
81 INT58243 Ghrh Regulation of Prl 1 0.04 0.18 0.21
82 INT268797 Ghrh Positive_regulation of Transcription of Gh 1 0.20 0.33 0.19
83 INT295542 Ghrl Positive_regulation of Gene_expression of Ghrh 1 0.33 0 0.19
84 INT295543 Ghrh Regulation of Gene_expression of Npy 1 0.36 0 0.16
85 INT222509 Ghrh Positive_regulation of Localization of Prl 1 0.28 0.23 0.16
86 INT295536 Ghrh Regulation of Npy 1 0.22 0 0.16
87 INT250533 Ghrh Regulation of Localization of Gh 1 0.13 0 0.15
88 INT250535 Ghrh Regulation of Gene_expression of Gh 1 0.31 0 0.15
89 INT31849 Ghrh Regulation of SST 1 0.09 0 0.14
90 INT31037 Binding of Gnrh1 and Ghrh 1 0.25 0 0.14
91 INT165367 Ghrh Regulation of Gnrh1 1 0.17 0.06 0.14
92 INT29465 NA Regulation of Localization of Ghrh 1 0.01 0 0.13
93 INT122192 Binding of Crhr2 and Ucn2 1 0.02 0.23 0.11
94 INT295538 Ghrh Positive_regulation of Gh 1 0.21 0 0.11
95 INT50300 Igf1 Positive_regulation of Gene_expression of Ghrh 1 0.26 0 0.11
96 INT205031 Crh Positive_regulation of Crhr2 1 0.45 1.11 0.11
97 INT31308 Positive_regulation of Ghrh Regulation of Gh1 1 0.14 0.69 0.1
98 INT31847 Ghrh Positive_regulation of Positive_regulation of Gh1 1 0.20 0 0.08
99 INT205033 Ucn Positive_regulation of Crhr2 1 0.22 0.15 0.08
100 INT31845 Negative_regulation of Ghrh Positive_regulation of Gh1 1 0.18 0 0.08
101 INT295550 Binding of Ghrh and Ghrl 1 0.21 0.06 0.07
102 INT165364 Ghrh Regulation of Localization of Gnrh1 1 0.09 0 0.05
103 INT163410 CRX Positive_regulation of Gene_expression of Crhr2 1 0.02 0.94 0.05
104 INT222508 Ghrh Regulation of Localization of LH 1 0.07 0 0.05
105 INT163411 CRX Negative_regulation of Gene_expression of Crhr2 1 0.02 0.94 0.05
106 INT222567 Negative_regulation of Gh1 Negative_regulation of Ghrh 1 0.03 0.19 0.04
107 INT222498 Ghrh Positive_regulation of Gene_expression of Ghrl 1 0.10 0.19 0.04
108 INT239605 Ghrh Negative_regulation of Gh 1 0.01 0.53 0.04
109 INT295532 Ghsr Positive_regulation of Localization of Ghrh 1 0.40 0 0.03
110 INT222469 Binding of Ucn and Crhr2 1 0.00 0 0.03
111 INT264801 Binding of Crhr2 and UCN2 1 0.00 0 0.03
112 INT11606 Regulation of Ghrh Regulation of Gh 1 0.06 0.05 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for positive regulation of cAMP metabolic process. They are ordered first by their pain relevance and then by number of times they were reported in positive regulation of cAMP metabolic process. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT5095 Localization of Ghrh 185 0.81 28.09 62.08
2 INT5100 Positive_regulation of Ghrh 100 0.64 24.2 30.21
3 INT7364 Regulation of Ghrh 49 0.58 8.05 19.05
4 INT9179 Positive_regulation of Localization of Ghrh 42 0.70 7.05 18.1
5 INT7366 Negative_regulation of Ghrh 42 0.58 7.72 14.45
6 INT16530 Gene_expression of Ghrh 45 0.77 6.22 13.44
7 INT19010 Negative_regulation of Localization of Ghrh 27 0.57 4.85 10.5
8 INT186142 Gene_expression of Ghrh 45 0.66 34.04 6.94
9 INT7925 Transcription of Ghrh 13 0.67 2.36 6.77
10 INT7361 Binding of Ghrh 13 0.45 1.37 5.44
11 INT9178 Regulation of Localization of Ghrh 13 0.45 2.28 5.08
12 INT19008 Positive_regulation of Positive_regulation of Ghrh 15 0.49 2.4 4.55
13 INT142059 Regulation of Ghrh 15 0.59 3.25 3.94
14 INT215029 Negative_regulation of Ghrh 15 0.56 11.37 2.62
15 INT20028 Positive_regulation of Gene_expression of Ghrh 9 0.50 1.52 2.62
16 INT122187 Positive_regulation of Crhr2 3 0.58 2.46 2.56
17 INT101955 Gene_expression of Crhr2 6 0.64 3.62 2.31
18 INT16527 Negative_regulation of Positive_regulation of Ghrh 6 0.43 1.01 2.23
19 INT27269 Localization of Ghrh 29 0.76 15.42 2.19
20 INT11604 Regulation of Positive_regulation of Ghrh 4 0.42 0.62 2.05
21 INT54929 Negative_regulation of Transcription of Ghrh 4 0.43 0.69 2.04
22 INT16529 Negative_regulation of Gene_expression of Ghrh 6 0.43 0.34 2.02
23 INT263035 Gene_expression of Gpr3 1 0.78 2.2 1.99
24 INT142060 Positive_regulation of Ghrh 15 0.66 7.21 1.83
25 INT142929 Regulation of Crhr2 1 0.44 1.28 1.73
26 INT101954 Binding of Crhr2 4 0.31 1.23 1.34
27 INT28888 Positive_regulation of Crhr2 6 0.68 3.8 1.23
28 INT104040 Regulation of Crhr2 2 0.36 1.29 0.81
29 INT101952 Negative_regulation of Crhr2 1 0.17 0.97 0.77
30 INT34944 Protein_catabolism of Ghrh 1 0.73 0 0.76
31 INT34943 Positive_regulation of Protein_catabolism of Ghrh 1 0.41 0 0.76
32 INT29460 Regulation of Gene_expression of Ghrh 3 0.31 0.3 0.68
33 INT64981 Regulation of Transcription of Ghrh 1 0.26 0.88 0.67
34 INT28889 Transcription of Crhr2 2 0.64 1.13 0.66
35 INT215025 Negative_regulation of Gene_expression of Ghrh 10 0.41 7.8 0.65
36 INT101674 Regulation of Regulation of Ghrh 1 0.38 0 0.65
37 INT61506 Localization of Ghrhr 1 0.51 0 0.61
38 INT101949 Negative_regulation of Binding of Crhr2 1 0.24 0.6 0.55
39 INT56670 Positive_regulation of Negative_regulation of Ghrh 2 0.49 0.12 0.48
40 INT69423 Positive_regulation of Regulation of Ghrh 1 0.50 0 0.48
41 INT250506 Negative_regulation of Positive_regulation of Ghrh 2 0.41 0.14 0.47
42 INT186141 Regulation of Gene_expression of Ghrh 2 0.29 0.87 0.43
43 INT148784 Negative_regulation of Crhr2 2 0.40 0.76 0.42
44 INT144599 Gene_expression of Crhr2 3 0.49 2.16 0.36
45 INT263033 Transcription of Gpr3 1 0.53 0.14 0.33
46 INT7360 Regulation of Binding of Ghrh 1 0.45 0.18 0.33
47 INT215024 Positive_regulation of Negative_regulation of Ghrh 2 0.44 1.54 0.3
48 INT187005 Positive_regulation of Gene_expression of Ghrh 9 0.48 8.02 0.29
49 INT72536 Phosphorylation of Ghrh 1 0.63 0 0.27
50 INT16219 Negative_regulation of Regulation of Ghrh 1 0.11 0.5 0.27
51 INT250511 Binding of Ghrh 2 0.35 0 0.24
52 INT143393 Transcription of Crhr2 1 0.52 0.19 0.21
53 INT112935 Binding of Crhr2 1 0.32 0.33 0.17
54 INT163408 Negative_regulation of Gene_expression of Crhr2 2 0.27 1.56 0.13
55 INT33547 Negative_regulation of Negative_regulation of Ghrh 2 0.42 0.62 0.12
56 INT262892 Gene_expression of Ghrhr 1 0.20 1.93 0.1
57 INT295524 Positive_regulation of Positive_regulation of Ghrh 1 0.48 0 0.1
58 INT165756 Positive_regulation of Gene_expression of Crhr2 1 0.31 0.62 0.07
59 INT205027 Positive_regulation of Positive_regulation of Crhr2 1 0.58 0.14 0.07
60 INT165755 Regulation of Gene_expression of Crhr2 1 0.28 0.62 0.07
61 INT263034 Negative_regulation of Gpr3 1 0.38 0 0.04
62 INT262891 Positive_regulation of Ghrhr 1 0.15 0.33 0
63 INT295518 Positive_regulation of Binding of Ghrh 1 0.48 0 0
64 INT205029 Regulation of Gene_expression of Crhr2 1 0.22 1.03 0
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