GO:0030818

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Name negative regulation of cAMP biosynthetic process
Categary Process
Go Slim No
Go Link GO:0030818
Unique Molecular Interactions 469
Total Molecular Interactions 649
Total Single Events 4917
Pain Genes Associated 29

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for negative regulation of cAMP biosynthetic process. They are ordered first by their pain relevance and then by number of times they were reported for negative regulation of cAMP biosynthetic process. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT123451 Binding of YY1 and Adra2a 1 0.37 0 2.98
2 INT25708 Oprl1 Positive_regulation of Adra2a 1 0.25 0.15 2.63
3 INT156799 Gria1 Regulation of Grm8 1 0.11 1.29 2.45
4 INT77807 Edn1 Positive_regulation of Gene_expression of Ptgs2 1 0.33 0.53 2.1
5 INT91607 Binding of EDN1 and POMC 1 0.12 0 1.9
6 INT253895 Binding of Htr1b and Htr1d 1 0.40 0.52 1.74
7 INT18786 Binding of Adra2a and Nisch 2 0.19 0 1.7
8 INT136034 Edn1 Regulation of Trpv1 2 0.66 0.39 1.58
9 INT95325 HTR1B Negative_regulation of Calca 1 0.47 0.69 1.43
10 INT31772 Ednra Positive_regulation of Nppa 1 0.05 0.13 1.33
11 INT95275 Binding of Edn1 and Ece1 1 0.32 2.09 1.3
12 INT95274 Regulation of Binding of Edn1 and Ece1 1 0.39 2.09 1.3
13 INT154203 Binding of Pick1 and Grm7 1 0.41 1.64 1.28
14 INT111211 Binding of Drd4 and Chdh 1 0.01 1.34 1.26
15 INT77806 Edn1 Regulation of Gene_expression of Ptgs2 1 0.29 1.24 1.22
16 INT62596 Binding of Edn1 and Nppa 1 0.27 1.77 1.22
17 INT110435 Positive_regulation of Grm8 Positive_regulation of Localization of Ca2 1 0.38 0 1.21
18 INT172500 Ednra Positive_regulation of Coc 1 0.01 1 1.2
19 INT201067 Binding of Edn1 and Ednra 2 0.18 1.36 1.18
20 INT14197 Pde2a Positive_regulation of Localization of Gh1 2 0.04 0 1.08
21 INT10238 Binding of EDN1 and Calca 1 0.00 1.07 1.06
22 INT41175 Adra2a Regulation of Th 1 0.59 0 1.04
23 INT63543 Binding of Adra2a and Serpini1 1 0.13 0 1
24 INT54972 Binding of EDNRA and EDNRB 7 0.52 3.31 0.97
25 INT152084 Edn1 Negative_regulation of Positive_regulation of Trpv1 1 0.62 0.48 0.96
26 INT127263 Adra2a Regulation of Gene_expression of Jun 1 0.07 1.1 0.95
27 INT136033 Edn1 Positive_regulation of Trpv1 1 0.50 0.34 0.95
28 INT77859 EDN1 Positive_regulation of MC1R 2 0.64 0.34 0.94
29 INT123023 Ednra Regulation of Adarb1 1 0.00 0 0.93
30 INT123024 Csf2 Regulation of Ednra 1 0.06 0 0.92
31 INT309708 Palm Regulation of Positive_regulation of Penk 1 0.19 1.25 0.91
32 INT28921 Adra2a Positive_regulation of Localization of Prl 1 0.24 0 0.9
33 INT43796 Binding of CDS1 and Adra2a 1 0.06 0 0.86
34 INT128701 Ednra Regulation of EDNRB 1 0.17 0.58 0.84
35 INT128702 Ednra Regulation of EDNRA 1 0.00 0.58 0.84
36 INT152083 Binding of Edn1 and Trpv1 1 0.38 0.67 0.83
37 INT122686 Binding of Galr3 and Th 1 0.14 0.07 0.83
38 INT153765 Positive_regulation of Edn1 Positive_regulation of Gtf3a 2 0.04 2.26 0.82
39 INT106859 EDN1 Positive_regulation of Transcription of MC1R 1 0.22 0 0.82
40 INT53377 Binding of Edn1 and Edn3 1 0.39 0 0.81
41 INT157918 TRPV1 Regulation of Gene_expression of Edn1 1 0.17 0.55 0.81
42 INT157913 Trpv1 Regulation of Gene_expression of Edn1 1 0.29 0.55 0.81
43 INT157915 Prkca Regulation of Gene_expression of Edn1 1 0.17 0.55 0.81
44 INT219911 Edn1 Regulation of Gene_expression of Trpv1 1 0.23 0.57 0.8
45 INT144062 Grm8 Regulation of Localization of Pag1 1 0.21 0.63 0.79
46 INT63544 Adra2a Regulation of Nisch 1 0.18 0 0.79
47 INT108611 Adra2a Regulation of Gene_expression of Nos1 1 0.10 0 0.75
48 INT84283 Binding of Adra2a and Htr1f 1 0.16 0.15 0.74
49 INT64117 Binding of Edn1 and Ins1 1 0.06 0.85 0.71
50 INT222493 Edn1 Positive_regulation of Localization of Prl 1 0.10 0 0.71
51 INT20688 Adra2a Regulation of Localization of Gh1 1 0.26 0.37 0.7
52 INT63557 Binding of Edn1 and Edn3 1 0.23 0.63 0.7
53 INT81968 Binding of PLEK and Adra2a 1 0.07 0.1 0.7
54 INT324900 VEGFA Positive_regulation of Gene_expression of Edn1 1 0.06 1.61 0.69
55 INT278827 Binding of EDN1 and EDNRB 3 0.17 2.7 0.67
56 INT134286 PLD2 Regulation of Regulation of EDNRA 1 0.10 0 0.67
57 INT26231 Binding of GSR and HTR1B 1 0.12 0.15 0.66
58 INT132152 Adra2a Regulation of Localization of Abat 1 0.03 0 0.66
59 INT153921 Positive_regulation of Adra2a Regulation of Ednrb 1 0.01 0 0.66
60 INT313702 Binding of Edn1 and Fig4 1 0.16 0 0.65
61 INT313698 Binding of Calca and Edn1 1 0.30 0 0.65
62 INT219921 EDNRA Negative_regulation of Trpv1 1 0.13 0.36 0.63
63 INT182266 EDN1 Positive_regulation of Gene_expression of MMP13 1 0.35 2.03 0.63
64 INT219919 EDNRA Negative_regulation of Edn1 1 0.15 0.36 0.63
65 INT178097 Binding of EDN1 and EDNRA 7 0.21 5.97 0.62
66 INT17187 Binding of Adra2a and Fabp6 1 0.16 0.69 0.61
67 INT230734 Negative_regulation of Binding of EDNRA and Pah 1 0.02 3.26 0.61
68 INT17186 Positive_regulation of Binding of Adra2a and Fabp6 1 0.21 0.69 0.61
69 INT230735 Binding of EDNRA and Pah 1 0.02 3.22 0.6
70 INT131642 Edn1 Positive_regulation of Positive_regulation of Insrr 1 0.01 0.44 0.6
71 INT178087 EDN1 Positive_regulation of MMP13 2 0.23 1.58 0.59
72 INT130162 Pomc Positive_regulation of Gene_expression of Edn1 1 0.25 0 0.58
73 INT98815 Binding of Crhr2 and Ucn 3 0.32 0.5 0.56
74 INT70468 Binding of HTR1B and MTG1 1 0.40 0 0.56
75 INT41250 Binding of Adra2a and Eef1a1 1 0.06 0.4 0.56
76 INT62597 Binding of Edn1 and Vip 1 0.23 0.79 0.54
77 INT333309 Binding of Htr1b and Adcy1 1 0.01 0 0.53
78 INT278824 Positive_regulation of Binding of EDNRA and EDNRB 1 0.12 1.65 0.53
79 INT110474 YY1 Positive_regulation of Positive_regulation of EDN1 1 0.56 0.15 0.53
80 INT130160 Pomc Regulation of Edn1 1 0.25 0 0.53
81 INT278825 Positive_regulation of Binding of EDN1 and EDNRB 3 0.16 1.24 0.49
82 INT94015 Binding of EDN1 and INSRR 1 0.04 0 0.49
83 INT94024 Binding of EDN1 and EDN3 1 0.27 0 0.49
84 INT7851 Man2a2 Positive_regulation of Adra2a 1 0.13 0 0.49
85 INT172207 Binding of Drd4 and ADHD1 2 0.03 1.56 0.48
86 INT146113 Binding of Adra2a and Lrp1 1 0.01 1.07 0.48
87 INT67983 Positive_regulation of HTR1B Positive_regulation of Localization of GHRH 1 0.42 0 0.47
88 INT99571 Edn1 Positive_regulation of Localization of Ednra 1 0.01 0.32 0.47
89 INT26448 Adra2a Regulation of Positive_regulation of Npy 1 0.06 0 0.46
90 INT110476 EDN1 Positive_regulation of Localization of PRKCZ 1 0.25 0.07 0.46
91 INT50497 Edn1 Positive_regulation of Pla2g1b 1 0.01 0.23 0.45
92 INT110475 EDN1 Regulation of PRKCA 1 0.05 0.07 0.45
93 INT219910 EDN1 Positive_regulation of Positive_regulation of EDNRA 1 0.00 0.3 0.45
94 INT94093 Pnoc Positive_regulation of EDNRA 1 0.03 0.1 0.44
95 INT86380 Adra2a Regulation of Gene_expression of Tnf 1 0.15 0.79 0.44
96 INT56576 Adra2a Positive_regulation of Localization of Gnrh1 1 0.44 0 0.43
97 INT55395 Binding of Htr1a and Adra2a 1 0.42 0 0.43
98 INT138384 Binding of Htr1b and ADHD1 2 0.07 1.46 0.42
99 INT275087 Pde2a Negative_regulation of stm 1 0.01 0.51 0.42
100 INT313704 Smn1 Negative_regulation of Gene_expression of Edn1 1 0.32 0 0.42
101 INT275104 Pde2a Negative_regulation of RTP3 1 0.00 0.51 0.42
102 INT153766 Edn1 Positive_regulation of Gtf3a 1 0.04 1.25 0.41
103 INT160971 Gm2111 Positive_regulation of Grm7 1 0.01 0.16 0.41
104 INT91545 Binding of HTR1B and CALCRL 1 0.01 0.09 0.41
105 INT34987 Adra2a Positive_regulation of Localization of Gnrhr 1 0.43 0 0.4
106 INT334763 Ednra Positive_regulation of Gabrg1 1 0.01 0 0.4
107 INT230724 EDN1 Positive_regulation of EDNRA 3 0.24 4.12 0.39
108 INT134167 Binding of ADRA2A and APLP1 1 0.09 0.64 0.39
109 INT77683 Ednra Negative_regulation of LH 1 0.03 0.23 0.39
110 INT99399 Penk Positive_regulation of Edn1 1 0.00 0 0.38
111 INT99400 Gast Positive_regulation of Edn1 1 0.00 0 0.38
112 INT185530 Binding of AGT and EDNRA 1 0.00 0.31 0.38
113 INT70656 Adra2a Regulation of Gene_expression of Npy 1 0.23 0 0.38
114 INT353391 Binding of DRD4 and GRB2 1 0.37 0.62 0.37
115 INT173704 Binding of PCOS1 and Edn1 1 0.01 0.99 0.37
116 INT313701 Calca Negative_regulation of Binding of Edn1 1 0.30 0.14 0.37
117 INT353392 Binding of DRD4 and NCK1 1 0.37 0.62 0.37
118 INT353390 Binding of DRD4 and SRC 1 0.25 0.62 0.37
119 INT134168 Binding of ADRA2B and APLP1 1 0.06 0.7 0.37
120 INT80444 Binding of EDNRA and SPR 1 0.05 0.1 0.36
121 INT152314 Il18 Regulation of Edn1 1 0.02 0.22 0.36
122 INT201068 Binding of Edn1 and Ednrb 2 0.18 1.23 0.35
123 INT152316 Ifng Regulation of Edn1 1 0.01 0.22 0.35
124 INT203395 Edn1 Positive_regulation of Vegfa 1 0.06 1.59 0.35
125 INT161796 Binding of ECE1 and EDN1 2 0.21 2.23 0.34
126 INT207576 RETN Positive_regulation of Gene_expression of EDN1 1 0.05 0.78 0.33
127 INT67030 Negative_regulation of Adra2a Negative_regulation of Etf1 1 0.00 0.64 0.33
128 INT143567 Edn1 Regulation of Ptgs2 1 0.26 0.17 0.33
129 INT67028 Adra2a Negative_regulation of Nts 1 0.06 0.64 0.33
130 INT80205 HTR1B Positive_regulation of Positive_regulation of HTR2A 1 0.54 0 0.33
131 INT67029 Adra2a Negative_regulation of Etf1 1 0.00 0.64 0.33
132 INT303030 Binding of Ednra and MCPH1 1 0.00 1.02 0.32
133 INT99842 Edn1 Negative_regulation of Localization of Ren 1 0.24 0.43 0.32
134 INT119603 H2-Ab1 Regulation of EDNRA 1 0.00 0.07 0.32
135 INT31182 Adra2a Regulation of Localization of Gh 1 0.01 0.35 0.32
136 INT119602 EDNRA Regulation of H2-Ab1 1 0.00 0.07 0.32
137 INT303005 Binding of Ednra and Pah 1 0.06 1.02 0.32
138 INT67266 Edn1 Negative_regulation of Ece1 1 0.19 0.17 0.32
139 INT182262 EDN1 Positive_regulation of Gene_expression of NOS2 1 0.28 0.79 0.31
140 INT258764 Binding of Drd4 and ADHD1 1 0.08 1.11 0.31
141 INT69365 Binding of EDNRA and Pnoc 1 0.00 0 0.31
142 INT71519 Edn1 Positive_regulation of Gene_expression of Adarb1 1 0.02 0.48 0.31
143 INT284137 EDNRB Regulation of EDNRA 1 0.07 0.09 0.3
144 INT117588 Binding of C5AR1 and EDNRA 1 0.40 0.38 0.3
145 INT191505 NLRP3 Positive_regulation of Protein_catabolism of EDN1 1 0.00 1.1 0.28
146 INT178102 EDNRA Positive_regulation of Localization of TIMP1 1 0.06 0.97 0.28
147 INT178088 EDNRA Positive_regulation of Transcription of TIMP1 1 0.06 0.97 0.28
148 INT349951 Grm7 Regulation of pcp 1 0.00 0.56 0.28
149 INT93260 Grm8 Regulation of Penk 1 0.08 0 0.28
150 INT98816 Crhr2 Positive_regulation of Negative_regulation of Ucn 1 0.33 0.09 0.28
151 INT241969 Grm8 Positive_regulation of Prkaca 1 0.05 0.35 0.27
152 INT95061 Binding of Adra2a and ADHD1 1 0.02 0.8 0.27
153 INT239226 Binding of Edn1 and Ednra 2 0.06 1.59 0.26
154 INT124117 Apcs Negative_regulation of Ednra 1 0.09 0 0.26
155 INT42635 Adra2a Positive_regulation of epi 1 0.00 0 0.26
156 INT241965 Prkaca Negative_regulation of Grm8 1 0.03 0.36 0.26
157 INT219918 Positive_regulation of EDNRA Positive_regulation of Trpv1 1 0.13 0 0.26
158 INT256227 Binding of EDN1 and VEGFA 1 0.18 2.92 0.25
159 INT178095 EDN1 Positive_regulation of MMP3 1 0.04 0.88 0.24
160 INT178076 EDN1 Positive_regulation of MMP2 1 0.04 0.88 0.24
161 INT178085 EDN1 Positive_regulation of MMP7 1 0.06 0.89 0.24
162 INT178141 EDN1 Positive_regulation of Timp1 1 0.30 0.89 0.24
163 INT36875 Binding of EDNRA and SYNCRIP 1 0.01 0 0.24
164 INT178075 EDN1 Positive_regulation of PLAU 1 0.06 0.95 0.24
165 INT178104 EDN1 Positive_regulation of Localization of TIMP1 1 0.05 0.83 0.24
166 INT178094 Positive_regulation of EDN1 Positive_regulation of PLAU 1 0.06 0.95 0.24
167 INT55641 Binding of CHRM1 and Adra2a 1 0.00 0 0.24
168 INT178142 EDN1 Positive_regulation of Localization of Timp1 1 0.28 0.89 0.24
169 INT128432 HTR1B Regulation of S100A4 1 0.49 0.28 0.24
170 INT178077 EDN1 Positive_regulation of MMP9 1 0.06 0.88 0.24
171 INT235125 PDE2A Negative_regulation of Twist1 1 0.00 0.99 0.24
172 INT182272 EDN1 Regulation of Gene_expression of MMP13 1 0.26 0.87 0.22
173 INT32735 ADRA2A Regulation of RTCA 1 0.07 0 0.22
174 INT91686 Mb Positive_regulation of Edn1 1 0.03 0.29 0.22
175 INT284139 EDNRB Positive_regulation of Gene_expression of EDNRA 1 0.12 0.45 0.22
176 INT182265 EDN1 Positive_regulation of NOS2 1 0.24 0.56 0.22
177 INT36876 EDNRA Regulation of Negative_regulation of PRB1 1 0.00 0 0.21
178 INT182263 EDN1 Positive_regulation of MMP1 1 0.15 0.43 0.21
179 INT78263 Npy Positive_regulation of Npy2r 1 0.04 0 0.21
180 INT106825 Ednra Negative_regulation of Igf1 1 0.07 0.07 0.2
181 INT178074 EDN1 Positive_regulation of Phosphorylation of PXN 1 0.05 0.82 0.2
182 INT178086 Binding of EDNRA and PTK2 1 0.07 0.82 0.2
183 INT274094 EDN1 Positive_regulation of AGT 1 0.16 0.95 0.2
184 INT182258 EDN1 Positive_regulation of Positive_regulation of MMP1 1 0.15 0.47 0.19
185 INT182271 EDN1 Positive_regulation of Localization of MMP13 1 0.27 0.47 0.19
186 INT219915 Edn1 Regulation of Positive_regulation of Trpv1 1 0.33 0 0.18
187 INT140096 Gtf3a Positive_regulation of Gene_expression of Edn1 1 0.02 0.44 0.18
188 INT171386 Edn1 Positive_regulation of Mapk1 1 0.05 0.13 0.18
189 INT60778 Edn1 Positive_regulation of EDNRA 1 0.00 0 0.18
190 INT284450 Edn1 Positive_regulation of Gene_expression of MMP9 1 0.01 0.3 0.18
191 INT140094 Ifng Regulation of Gene_expression of Edn1 1 0.18 0.44 0.18
192 INT334769 Ednra Positive_regulation of Car2 1 0.02 0.49 0.18
193 INT178073 EDN1 Positive_regulation of PTK2 1 0.03 1.02 0.17
194 INT203759 Binding of EDN1 and TNF 1 0.16 0.71 0.16
195 INT324899 Edn1 Positive_regulation of Positive_regulation of Mmp9 1 0.10 0.66 0.16
196 INT94022 Positive_regulation of Binding of EDN1 and INSRR 1 0.06 0 0.16
197 INT178079 EDN1 Positive_regulation of Positive_regulation of AKT1 1 0.05 0.91 0.16
198 INT94021 Binding of EDN1 and EDN2 1 0.26 0 0.16
199 INT241967 Binding of Grm7 and Acpt 1 0.17 0 0.16
200 INT94014 Positive_regulation of Binding of EDN1 and EDN3 1 0.36 0 0.16

Single Events

The table below shows the top 100 pain related interactions that have been reported for negative regulation of cAMP biosynthetic process. They are ordered first by their pain relevance and then by number of times they were reported in negative regulation of cAMP biosynthetic process. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT7059 Regulation of Adra2a 89 0.62 18.24 48.43
2 INT5781 Gene_expression of Edn1 190 0.78 99.1 46
3 INT7608 Positive_regulation of Adra2a 66 0.70 17.81 35.15
4 INT8905 Gene_expression of EDN1 215 0.78 157.1 34.19
5 INT6364 Gene_expression of Edn1 123 0.78 73.76 28.43
6 INT7779 Negative_regulation of Adra2a 47 0.58 9.45 28
7 INT7717 Positive_regulation of Adra2a 62 0.70 17.68 27.32
8 INT23937 Gene_expression of EDNRA 103 0.65 55.63 24.67
9 INT6726 Positive_regulation of Edn1 118 0.70 65.96 24.07
10 INT15390 Positive_regulation of Edn1 64 0.70 47.36 23.8
11 INT48536 Positive_regulation of Grm8 46 0.61 14.31 23.56
12 INT9282 Gene_expression of HTR1B 48 0.75 12.15 22.94
13 INT8248 Binding of Adra2a 43 0.48 6.72 22.17
14 INT9782 Binding of HTR1B 43 0.47 12.08 19.83
15 INT3030 Gene_expression of Adra2a 37 0.68 5.58 19.76
16 INT8662 Positive_regulation of EDN1 144 0.70 125.34 19.59
17 INT5048 Binding of Edn1 55 0.47 18.86 19.16
18 INT14114 Binding of Adra2a 30 0.48 4.24 18.53
19 INT9358 Positive_regulation of HTR1B 26 0.67 11 17.51
20 INT6728 Gene_expression of Ednra 43 0.65 13.41 17.38
21 INT12875 Regulation of Adra2a 26 0.45 7.51 17.35
22 INT5674 Gene_expression of Adra2a 34 0.77 6.14 15.13
23 INT9191 Localization of EDN1 94 0.81 57.01 14.78
24 INT74745 Gene_expression of Grm8 30 0.68 9.85 14.52
25 INT8904 Positive_regulation of Gene_expression of EDN1 66 0.70 65.4 14.42
26 INT5806 Regulation of Edn1 63 0.62 23.46 13.88
27 INT6365 Localization of Edn1 56 0.81 18.84 13.83
28 INT21979 Negative_regulation of EDN1 52 0.58 24.65 12.55
29 INT70905 Positive_regulation of EDNRA 49 0.67 24.33 11.79
30 INT12455 Negative_regulation of Adra2a 30 0.54 5.63 10.14
31 INT10184 Regulation of EDN1 44 0.62 23.78 10.06
32 INT6361 Localization of Edn1 30 0.81 19.09 9.7
33 INT17101 Positive_regulation of Gene_expression of Edn1 24 0.69 24.9 8.86
34 INT12095 Negative_regulation of Edn1 26 0.59 12.01 8.79
35 INT6727 Positive_regulation of Ednra 27 0.64 18.75 8.71
36 INT48088 Regulation of Grm8 12 0.62 4.93 8.71
37 INT10237 Binding of EDN1 40 0.48 16 8.48
38 INT30382 Negative_regulation of Ednra 21 0.42 12.06 8.19
39 INT73544 Gene_expression of Grm7 34 0.64 31.28 8.04
40 INT56580 Positive_regulation of Htr1b 16 0.67 2.95 7.97
41 INT13041 Binding of Htr1b 14 0.47 4.92 7.95
42 INT77804 Regulation of Ednra 9 0.39 2.71 7.94
43 INT54978 Binding of EDNRA 36 0.41 14.97 7.86
44 INT10899 Positive_regulation of Gene_expression of Edn1 32 0.70 24.88 7.65
45 INT67170 Gene_expression of Ednra 22 0.65 9.35 7.57
46 INT6892 Regulation of Htr1b 9 0.60 1.32 7.24
47 INT10104 Negative_regulation of Edn1 43 0.59 15.63 7.2
48 INT6576 Localization of Adra2a 11 0.71 1.49 7.18
49 INT25772 Regulation of HTR1B 15 0.60 3.8 7.17
50 INT15553 Negative_regulation of Htr1b 13 0.41 2.61 7.16
51 INT167049 Binding of Ednra 3 0.07 3.47 6.84
52 INT21138 Binding of ADRA2A 16 0.48 5.57 6.8
53 INT79822 Gene_expression of Htr1b 10 0.65 2.92 6.27
54 INT83313 Gene_expression of Htr1b 4 0.75 5.1 5.73
55 INT96510 Localization of Htr1b 6 0.78 2.31 5.51
56 INT70907 Negative_regulation of EDNRA 30 0.36 19.68 5.49
57 INT60776 Regulation of EDNRA 20 0.51 16.62 5.36
58 INT188852 Gene_expression of Pde2a 13 0.19 6.44 5.35
59 INT66305 Negative_regulation of HTR1B 9 0.57 1.7 5.15
60 INT13650 Positive_regulation of Gene_expression of Adra2a 6 0.50 0.69 4.94
61 INT92858 Negative_regulation of Ednra 6 0.57 1.25 4.81
62 INT17803 Regulation of Edn1 14 0.54 4.75 4.71
63 INT7716 Positive_regulation of Positive_regulation of Adra2a 9 0.68 0.8 4.69
64 INT246315 Localization of Ednra 22 0.15 2.73 4.64
65 INT21953 Binding of Ednra 12 0.33 4.72 4.56
66 INT79682 Gene_expression of Grm7 6 0.75 4.74 4.5
67 INT75440 Regulation of Binding of Edn1 4 0.38 1.41 4.33
68 INT88274 Positive_regulation of Drd4 7 0.69 3.48 4.1
69 INT89516 Negative_regulation of Grm8 7 0.41 4.01 3.82
70 INT116220 Localization of HTR1B 5 0.78 1.86 3.75
71 INT79680 Binding of Grm7 6 0.47 2.83 3.58
72 INT86082 Localization of Htr1b 4 0.73 2.77 3.46
73 INT95272 Regulation of Gene_expression of Edn1 19 0.53 17.85 3.42
74 INT59706 Transcription of HTR1B 5 0.69 0.4 3.4
75 INT115203 Negative_regulation of Positive_regulation of Ednra 5 0.33 1.27 3.32
76 INT109095 Binding of Drd4 7 0.40 3.6 3.18
77 INT75815 Positive_regulation of PDE2A 10 0.40 5.1 3.15
78 INT49971 Regulation of Ednra 10 0.35 2.4 3.06
79 INT17389 Negative_regulation of Positive_regulation of Adra2a 6 0.58 0.99 3.06
80 INT88273 Gene_expression of Drd4 6 0.54 1.84 3.01
81 INT53374 Binding of Edn1 17 0.43 11.66 2.98
82 INT97218 Regulation of Gene_expression of Grm8 3 0.24 2.26 2.97
83 INT7931 Positive_regulation of Protein_catabolism of Adra2a 1 0.70 0 2.9
84 INT31923 Positive_regulation of Positive_regulation of Adra2a 7 0.44 1.88 2.89
85 INT78253 Gene_expression of Npy2r 7 0.77 1.49 2.89
86 INT93058 Positive_regulation of Gene_expression of Ednra 8 0.28 4.11 2.88
87 INT144955 Binding of Grm8 8 0.22 1.82 2.83
88 INT147412 Binding of DRD4 11 0.47 7.57 2.77
89 INT30172 Positive_regulation of Pde2a 3 0.39 0.55 2.77
90 INT76836 Positive_regulation of Ednra 6 0.55 2.65 2.72
91 INT31451 Negative_regulation of Gene_expression of Adra2a 4 0.43 1.03 2.72
92 INT100014 Negative_regulation of Gene_expression of EDN1 17 0.42 7.85 2.71
93 INT189863 Gene_expression of DRD4 11 0.68 7.65 2.66
94 INT122677 Gene_expression of Galr3 1 0.66 0.24 2.65
95 INT110735 Regulation of Positive_regulation of Grm8 3 0.40 1.19 2.62
96 INT122187 Positive_regulation of Crhr2 3 0.58 2.46 2.56
97 INT88272 Gene_expression of Drd4 5 0.66 1.07 2.53
98 INT144956 Negative_regulation of Gene_expression of Grm8 7 0.29 2.53 2.5
99 INT43212 Regulation of Gene_expression of Adra2a 4 0.45 0.24 2.48
100 INT9357 Positive_regulation of Positive_regulation of HTR1B 5 0.49 0.88 2.47
101 INT168658 Regulation of Gene_expression of HTR1B 2 0.44 2.11 2.44
102 INT12456 Negative_regulation of Positive_regulation of Adra2a 4 0.37 1.35 2.42
103 INT101955 Gene_expression of Crhr2 6 0.64 3.62 2.31
104 INT57664 Gene_expression of Npy2r 4 0.19 1.41 2.26
105 INT53587 Positive_regulation of Binding of Adra2a 1 0.12 0 2.26
106 INT55853 Positive_regulation of Positive_regulation of Edn1 11 0.61 6.5 2.21
107 INT96403 Transcription of Htr1b 2 0.67 0.81 2.14
108 INT34196 Regulation of Binding of Adra2a 2 0.45 0 2.12
109 INT49253 Regulation of Gene_expression of EDN1 11 0.61 3.92 2.07
110 INT86083 Positive_regulation of Htr1b 5 0.45 2.01 2.05
111 INT156677 Regulation of Gene_expression of Ednra 4 0.15 0.25 2.05
112 INT31262 Positive_regulation of Binding of Adra2a 4 0.10 1.02 2.04
113 INT49259 Regulation of Localization of EDN1 8 0.61 6.29 1.92
114 INT23426 Regulation of ADRA2A 8 0.48 1.81 1.88
115 INT76834 Negative_regulation of Gene_expression of Edn1 4 0.43 1.76 1.88
116 INT253894 Regulation of Localization of Htr1b 1 0.44 0.61 1.82
117 INT64530 Negative_regulation of Positive_regulation of Pde2a 1 0.36 0 1.81
118 INT79815 Positive_regulation of Localization of Edn1 7 0.68 2.07 1.79
119 INT122435 Positive_regulation of Grm7 3 0.00 1.89 1.79
120 INT8661 Positive_regulation of Positive_regulation of EDN1 10 0.66 10.9 1.76
121 INT173700 Negative_regulation of Binding of Edn1 2 0.58 0.41 1.76
122 INT79683 Negative_regulation of Grm7 3 0.41 2.22 1.75
123 INT122679 Binding of Galr3 1 0.36 0.16 1.73
124 INT142929 Regulation of Crhr2 1 0.44 1.28 1.73
125 INT12781 Regulation of Pde2a 4 0.23 1.14 1.69
126 INT14842 Negative_regulation of Binding of EDN1 4 0.57 0.67 1.66
127 INT64529 Localization of Pde2a 1 0.59 0 1.63
128 INT1580 Negative_regulation of Pde2a 7 0.52 3.26 1.59
129 INT138083 Positive_regulation of Gene_expression of Drd4 2 0.40 1.34 1.55
130 INT72021 Localization of Ednra 7 0.58 3.13 1.53
131 INT188855 Positive_regulation of Gene_expression of Pde2a 5 0.12 1.97 1.53
132 INT43327 Positive_regulation of ADRA2A 3 0.46 1.54 1.53
133 INT181579 Phosphorylation of Edn1 1 0.71 8.59 1.51
134 INT15407 Positive_regulation of Positive_regulation of Edn1 5 0.62 3.69 1.49
135 INT24768 Negative_regulation of Gene_expression of Edn1 10 0.43 2.85 1.48
136 INT74746 Transcription of Grm8 5 0.45 0.45 1.48
137 INT7780 Positive_regulation of Negative_regulation of Adra2a 2 0.50 0.09 1.48
138 INT65640 Positive_regulation of Localization of Edn1 2 0.42 2.16 1.48
139 INT23938 Positive_regulation of Gene_expression of EDNRA 8 0.45 9.82 1.47
140 INT129488 Regulation of Gene_expression of EDNRA 5 0.51 3.39 1.44
141 INT66527 Positive_regulation of Npy2r 2 0.31 0.47 1.44
142 INT7932 Protein_catabolism of Adra2a 1 1.00 0 1.44
143 INT53632 Regulation of Negative_regulation of Adra2a 1 0.23 0.08 1.41
144 INT29262 Negative_regulation of Binding of Adra2a 4 0.40 0.25 1.37
145 INT79681 Localization of Grm7 5 0.78 2.57 1.34
146 INT101954 Binding of Crhr2 4 0.31 1.23 1.34
147 INT14195 Localization of Pde2a 4 0.16 0.34 1.33
148 INT95815 Regulation of Positive_regulation of Adra2a 4 0.45 1.45 1.32
149 INT69498 Positive_regulation of DRD4 3 0.50 0.95 1.3
150 INT7847 Positive_regulation of Localization of Adra2a 2 0.40 0.22 1.28
151 INT28888 Positive_regulation of Crhr2 6 0.68 3.8 1.23
152 INT79489 Transcription of Adra2a 2 0.61 2.38 1.22
153 INT130323 Regulation of Grm7 3 0.26 1.9 1.21
154 INT17802 Transcription of Edn1 6 0.24 6.31 1.18
155 INT66306 Negative_regulation of Transcription of HTR1B 1 0.42 0.14 1.15
156 INT49258 Negative_regulation of Positive_regulation of EDN1 10 0.43 7.24 1.12
157 INT7834 Gene_expression of Pde2a 5 0.51 1.9 1.01
158 INT12976 Negative_regulation of ADRA2A 4 0.50 0.16 1.01
159 INT69803 Regulation of Localization of Edn1 3 0.62 0.79 0.98
160 INT72024 Localization of EDNRA 11 0.57 8.22 0.96
161 INT76835 Negative_regulation of Gene_expression of Ednra 2 0.10 0.89 0.96
162 INT66526 Regulation of Positive_regulation of Npy2r 1 0.20 0 0.96
163 INT49255 Protein_catabolism of EDN1 5 0.99 2.66 0.95
164 INT69422 Positive_regulation of Negative_regulation of EDN1 2 0.43 0.96 0.95
165 INT80315 Binding of Npy2r 2 0.48 0.53 0.95
166 INT20687 Positive_regulation of Regulation of Adra2a 1 0.35 1.07 0.95
167 INT49254 Transcription of EDN1 5 0.69 2.42 0.94
168 INT122678 Positive_regulation of Gene_expression of Galr3 1 0.49 0.08 0.94
169 INT188851 Regulation of Gene_expression of Pde2a 1 0.04 0.75 0.94
170 INT158378 Transcription of Grm7 1 0.00 0.65 0.94
171 INT18801 Negative_regulation of Negative_regulation of Adra2a 2 0.43 0 0.91
172 INT152081 Phosphorylation of Edn1 1 0.53 0.39 0.9
173 INT178133 Negative_regulation of Positive_regulation of EDNRA 2 0.35 2.18 0.88
174 INT61591 Negative_regulation of Localization of EDN1 11 0.59 2.09 0.85
175 INT57433 Positive_regulation of Binding of EDN1 3 0.49 0.62 0.82
176 INT88271 Positive_regulation of Drd4 2 0.19 0.5 0.82
177 INT89776 Positive_regulation of Pde2a 2 0.47 2.84 0.81
178 INT104040 Regulation of Crhr2 2 0.36 1.29 0.81
179 INT86084 Negative_regulation of Regulation of Htr1b 1 0.35 0.23 0.8
180 INT98275 Negative_regulation of PDE2A 4 0.17 3.96 0.79
181 INT86086 Regulation of Htr1b 1 0.37 0.23 0.79
182 INT80316 Positive_regulation of Npy2r 3 0.31 0.28 0.78
183 INT14770 Localization of Adra2a 2 0.60 0.1 0.78
184 INT101952 Negative_regulation of Crhr2 1 0.17 0.97 0.77
185 INT186579 Positive_regulation of Gene_expression of Ednra 5 0.07 0.89 0.76
186 INT18836 Localization of ADRA2A 2 0.38 0.33 0.76
187 INT86085 Negative_regulation of Htr1b 1 0.48 0.25 0.76
188 INT61121 Regulation of Regulation of Edn1 1 0.43 0.2 0.75
189 INT11102 Negative_regulation of Regulation of Adra2a 2 0.42 1.5 0.71
190 INT59970 Positive_regulation of Binding of Edn1 2 0.40 1.11 0.71
191 INT313697 Phosphorylation of Ednra 1 0.18 0 0.7
192 INT21957 Negative_regulation of Negative_regulation of Edn1 5 0.43 1.34 0.69
193 INT170705 Localization of Grm8 4 0.33 0.34 0.69
194 INT91056 Negative_regulation of Gene_expression of Grm7 2 0.18 1.21 0.69
195 INT134173 Binding of APLP1 4 0.37 2.41 0.67
196 INT183161 Regulation of Pde2a 2 0.05 0.5 0.67
197 INT253893 Negative_regulation of Gene_expression of Htr1b 1 0.41 0.08 0.67
198 INT49252 Positive_regulation of Localization of EDN1 17 0.69 6.55 0.66
199 INT100396 Transcription of Edn1 7 0.69 2.48 0.66
200 INT7609 Regulation of Positive_regulation of Adra2a 3 0.32 0.59 0.66
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