GO:0030828

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Name positive regulation of cGMP biosynthetic process
Categary Process
Go Slim No
Go Link GO:0030828
Unique Molecular Interactions 185
Total Molecular Interactions 261
Total Single Events 2189
Pain Genes Associated 13

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for positive regulation of cGMP biosynthetic process. They are ordered first by their pain relevance and then by number of times they were reported for positive regulation of cGMP biosynthetic process. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT11599 Calca Positive_regulation of Npr1 5 0.19 0.3 4.8
2 INT7022 Drd1a Positive_regulation of Npr1 6 0.05 0.26 4.32
3 INT111787 Cck Regulation of Gene_expression of Npr1 1 0.22 1.68 2.57
4 INT33756 Akr1d1 Positive_regulation of Npr1 3 0.01 0 2.05
5 INT21261 Penk Negative_regulation of Npr1 1 0.02 0 2
6 INT7023 Negative_regulation of Drd1a Positive_regulation of Npr1 2 0.05 0.1 1.81
7 INT68709 Positive_regulation of Crh Regulation of Npr1 1 0.03 0 1.71
8 INT68710 Crh Regulation of Npr1 1 0.03 0 1.7
9 INT96296 Oprm1 Negative_regulation of Npr1 2 0.05 0.32 1.65
10 INT33757 Hmmr Positive_regulation of Npr1 1 0.01 0 1.59
11 INT6466 Binding of Npr1 and Oprd1 1 0.01 0 1.37
12 INT143620 Ltp Positive_regulation of Npr1 1 0.01 0.16 1.26
13 INT42554 Oprl1 Regulation of Npr1 2 0.06 0 1.22
14 INT13205 Oprd1 Negative_regulation of Npr1 2 0.01 0 1.16
15 INT13204 Binding of Npr1 and Akr1d1 1 0.00 0 1.14
16 INT7024 Regulation of Drd1a Positive_regulation of Npr1 1 0.04 0.07 1.13
17 INT33142 Pck1 Positive_regulation of Npr1 4 0.01 0.5 1.02
18 INT13502 Penk Positive_regulation of Npr1 1 0.02 0.19 1.01
19 INT13503 Regulation of Penk Positive_regulation of Npr1 1 0.02 0.19 1.01
20 INT7025 Positive_regulation of Drd1a Positive_regulation of Npr1 1 0.04 0.08 1.01
21 INT42555 Oprl1 Negative_regulation of Npr1 1 0.02 0 0.99
22 INT216736 Binding of ADORA2B and ATP6V0A1 2 0.08 0.06 0.93
23 INT297332 Apoe Negative_regulation of Gene_expression of Mpz 1 0.02 1.09 0.87
24 INT111790 Penk Regulation of Gene_expression of Npr1 1 0.22 0.56 0.86
25 INT194856 Positive_regulation of Adora2b Negative_regulation of Positive_regulation of Mmp13 1 0.01 0.73 0.85
26 INT41156 Sst Negative_regulation of Npr1 1 0.05 0 0.84
27 INT29781 PDYN Negative_regulation of Npr1 1 0.00 0.22 0.84
28 INT252455 Binding of Adora2b and SLURP1 1 0.02 0.6 0.81
29 INT208354 Binding of Apoe and Hdl1 12 0.13 8.37 0.77
30 INT298457 Binding of Calca and Npr1 1 0.01 0.39 0.77
31 INT21260 Positive_regulation of Drd1a Positive_regulation of Npr1 1 0.05 0 0.76
32 INT147619 Npr1 Positive_regulation of Localization of Calca 1 0.03 0 0.75
33 INT57658 ASNA1 Positive_regulation of Npr1 1 0.00 0.15 0.74
34 INT169603 Nppb Regulation of Npr1 1 0.26 0.95 0.69
35 INT71988 Drd1a Regulation of Npr1 1 0.10 0 0.68
36 INT111555 Negative_regulation of Npr1 Negative_regulation of Positive_regulation of Creb1 1 0.02 0.58 0.66
37 INT6464 Sst Regulation of Negative_regulation of Npr1 1 0.01 0 0.64
38 INT6463 Oprd1 Regulation of Negative_regulation of Npr1 1 0.01 0 0.63
39 INT6465 Trh Regulation of Negative_regulation of Npr1 1 0.01 0 0.63
40 INT297344 Apoe Regulation of Binding of Alms1 1 0.08 1.1 0.61
41 INT297340 Apoe Regulation of Binding of Smo 1 0.10 1.1 0.6
42 INT297331 Apoe Negative_regulation of Gene_expression of Il6 1 0.14 0.61 0.57
43 INT254761 Igh-Dex Positive_regulation of Apoe 1 0.00 0.08 0.52
44 INT43075 Slc6a14 Regulation of Positive_regulation of Npr1 1 0.01 0 0.51
45 INT43076 Slc6a14 Regulation of Npr1 1 0.01 0 0.51
46 INT116862 Apoe Positive_regulation of Il10 1 0.30 0.69 0.5
47 INT116863 Apoe Negative_regulation of Hand1 1 0.37 0.69 0.5
48 INT254768 DNMT1 Positive_regulation of Gene_expression of Apoe 1 0.02 0.05 0.49
49 INT233503 Tlr4 Positive_regulation of Adora2b 1 0.06 0.45 0.47
50 INT197496 Binding of Apoe and Lrp1 4 0.22 2.32 0.46
51 INT55265 Ptgdr Negative_regulation of Npr1 1 0.01 0 0.46
52 INT52679 Positive_regulation of Npr1 Positive_regulation of Positive_regulation of VSX1 1 0.00 0 0.45
53 INT142608 Apoe Regulation of Gene_expression of Il6 1 0.25 1.01 0.44
54 INT170157 NPPC Regulation of CSF2 1 0.12 1.36 0.42
55 INT254760 Igh-Dex Positive_regulation of Gene_expression of Apoe 1 0.00 0 0.42
56 INT329085 Csf2 Positive_regulation of Apoe 1 0.00 1.23 0.42
57 INT131353 Binding of Npr1 and Nppb 1 0.27 1.73 0.4
58 INT131356 Binding of Nppa and Npr1 1 0.27 1.73 0.4
59 INT57649 Oprd1 Positive_regulation of Npr1 1 0.01 0.1 0.39
60 INT95999 Binding of Npr1 and Cnr1 1 0.05 0 0.39
61 INT216737 Binding of ADORA2B and TCFL5 1 0.03 0.05 0.39
62 INT169604 Nppb Positive_regulation of Npr1 2 0.52 2.52 0.37
63 INT154356 Binding of Nppc and ITS 1 0.00 0.85 0.35
64 INT254123 Binding of Adora2b and Rai1 1 0.24 0.75 0.35
65 INT84085 Binding of Gucy1a2 and Nisch 1 0.00 0.22 0.35
66 INT252453 Binding of AR and Adora2b 1 0.05 0 0.35
67 INT115261 Gene_expression of Nos2 Positive_regulation of Positive_regulation of Npr1 1 0.05 0.67 0.31
68 INT241739 Sdhb Regulation of Adora2b 1 0.04 0.63 0.31
69 INT96436 Binding of Npr1 and Oprl1 1 0.05 0 0.29
70 INT254759 Igh-Dex Positive_regulation of Localization of Apoe 1 0.00 0.32 0.28
71 INT254769 Binding of LDLR and Apoe 1 0.03 0 0.28
72 INT297338 Apoe Regulation of Gnb5 1 0.06 1.12 0.27
73 INT136245 Gucy1a2 Positive_regulation of Nppa 1 0.06 0.22 0.27
74 INT208499 Positive_regulation of Nkx1-1 Positive_regulation of Npr1 1 0.00 0 0.27
75 INT149358 Binding of Oprm1 and Positive_regulation of Positive_regulation of Npr1 1 0.00 0.09 0.26
76 INT83220 Gucy1a2 Positive_regulation of Positive_regulation of Glp1r 1 0.02 0 0.26
77 INT136246 Gucy1a2 Negative_regulation of Nppa 1 0.05 0.22 0.26
78 INT47012 Regulation of Pck1 Positive_regulation of Npr1 1 0.01 0 0.26
79 INT254772 DNMT1 Positive_regulation of Apoe 1 0.02 0 0.25
80 INT78293 Binding of Apoe and Ldlr 1 0.20 0.25 0.24
81 INT78295 Binding of Ptpra and Apoe 1 0.42 0.25 0.24
82 INT252456 IGKV2D-29 Regulation of Gene_expression of Adora2b 1 0.07 0 0.24
83 INT297334 Gnb5 Regulation of Apoe 1 0.09 0.83 0.24
84 INT78294 Negative_regulation of Binding of Ptpra and Apoe 1 0.48 0.25 0.24
85 INT254773 PPARA Positive_regulation of Gene_expression of Apoe 1 0.01 0.07 0.24
86 INT78292 Negative_regulation of Binding of Apoe and Ldlr 1 0.23 0.25 0.24
87 INT224135 Binding of ARRB2 and Adora2b 1 0.14 0.07 0.23
88 INT254774 DNMT1 Positive_regulation of Localization of Apoe 1 0.01 0.31 0.23
89 INT146993 Binding of NPPA and NPPC 1 0.27 0.82 0.22
90 INT131355 Npr1 Regulation of Nppb 1 0.39 0.88 0.22
91 INT131354 Npr1 Regulation of Nppa 1 0.40 0.88 0.22
92 INT224133 Negative_regulation of Adora2b Positive_regulation of ADCY1 1 0.01 0.1 0.2
93 INT134494 Binding of APOE and Alb 1 0.11 0.45 0.2
94 INT25089 Glul Positive_regulation of Npr1 1 0.00 0 0.2
95 INT224134 Adora2b Positive_regulation of ADCY1 1 0.01 0.1 0.2
96 INT226542 Negative_regulation of Adora2b Positive_regulation of IL19 1 0.08 0.58 0.2
97 INT226525 Adora2b Positive_regulation of IL19 1 0.03 0.58 0.2
98 INT154355 Binding of Nppc and Npr1 1 0.19 0.43 0.18
99 INT29959 Ahsp Positive_regulation of Npr1 1 0.00 0.18 0.17
100 INT208360 Binding of Abca1 and Apoe 1 0.15 0.74 0.17
101 INT197499 Binding of Apoe and Tfrc 1 0.14 1.54 0.17
102 INT252454 Negative_regulation of Binding of Adora2b and SLURP1 1 0.02 0.33 0.16
103 INT122528 Apoe Regulation of Eno2 1 0.05 0.29 0.16
104 INT33141 Pck1 Regulation of Npr1 1 0.00 0.17 0.16
105 INT122529 Apoe Regulation of S100B 1 0.18 0.29 0.16
106 INT224136 ARRB2 Positive_regulation of Adora2b 1 0.19 0 0.16
107 INT297345 Apoe Negative_regulation of Csf2 1 0.17 0.66 0.16
108 INT310595 Ros1 Positive_regulation of Npr1 1 0.03 0.84 0.16
109 INT251435 Gnat3 Positive_regulation of NPR1 1 0.22 0.2 0.15
110 INT224132 ARRB2 Negative_regulation of Positive_regulation of Adora2b 1 0.14 0.28 0.15
111 INT297333 Apoe Negative_regulation of Positive_regulation of Tlr4 1 0.10 1.02 0.14
112 INT297343 Binding of Apoe and Tlr4 1 0.09 0.94 0.14
113 INT297339 Tlr4 Negative_regulation of Gene_expression of Apoe 1 0.10 0.73 0.13
114 INT170159 Negative_regulation of NPPC Regulation of CSF2 1 0.20 0.33 0.11
115 INT208361 Positive_regulation of Binding of Apoe and Hdl1 1 0.12 1.22 0.1
116 INT25090 Negative_regulation of Glul Positive_regulation of Npr1 1 0.00 0 0.1
117 INT43284 Binding of Npr1 and Gcg 1 0.05 0 0.1
118 INT297346 Apoe Negative_regulation of Localization of TNF 1 0.48 0.26 0.1
119 INT164428 Gsta3 Positive_regulation of Npr1 1 0.00 0 0.1
120 INT46240 Npr1 Positive_regulation of Localization of Avp 1 0.05 0 0.09
121 INT25269 Hmmr Negative_regulation of Npr1 1 0.01 0.63 0.08
122 INT91097 Ptprg Positive_regulation of Npr1 1 0.00 0.62 0.08
123 INT205135 Binding of APOE and APP 1 0.05 0.35 0.08
124 INT241741 Sdhb Positive_regulation of Transcription of Adora2b 1 0.07 0.28 0.08
125 INT257226 Phosphorylation of Prkacb Positive_regulation of Npr1 1 0.00 0 0.08
126 INT300641 Binding of APOE and CRP 1 0.41 0.81 0.07
127 INT297330 Apoe Positive_regulation of Gene_expression of Nos2 1 0.26 0.34 0.07
128 INT308665 Binding of Apoe and Gopc 1 0.02 0.49 0.07
129 INT308663 Apoe Regulation of Car2 1 0.02 0.44 0.07
130 INT146721 Nppc Positive_regulation of Positive_regulation of Oprl1 1 0.16 0.34 0.07
131 INT50078 Binding of APOE and NPPA 1 0.30 0.42 0.07
132 INT326067 APOA1 Positive_regulation of Localization of APOE 1 0.61 4.22 0.07
133 INT91098 Gcgr Positive_regulation of Npr1 1 0.01 0.38 0.06
134 INT43283 Gcg Positive_regulation of Npr1 1 0.07 0 0.05
135 INT251468 Binding of APOE and DBT 1 0.03 1.18 0.05
136 INT171399 Binding of Npr1 and Prkcg 1 0.00 0.23 0.04
137 INT208356 Hdl1 Positive_regulation of Apoe 1 0.12 1.25 0.04
138 INT171401 Binding of Adcyap1 and Npr1 1 0.02 0.23 0.04
139 INT235551 Gene_expression of Hras1 Negative_regulation of Positive_regulation of Apoe 1 0.03 0.57 0.04
140 INT208357 Hdl1 Positive_regulation of Localization of Apoe 1 0.12 1.26 0.04
141 INT208350 Positive_regulation of Hdl1 Positive_regulation of Apoe 1 0.12 1.27 0.04
142 INT290181 Binding of APOE and PLTP 1 0.17 1.61 0.04
143 INT44815 Sct Positive_regulation of Npr1 1 0.06 0 0.03
144 INT194483 Binding of Apoe and Chol1 1 0.24 0.51 0.03
145 INT208352 Apoe Regulation of Localization of Em 1 0.04 1.15 0.03
146 INT194481 Binding of Apoe and Apob 1 0.07 0.51 0.03
147 INT308658 Binding of Apoa2 and Apoe 1 0.17 0.15 0.03
148 INT341487 Binding of APOE and TLR2 1 0.00 0.3 0
149 INT326065 APOE Positive_regulation of LCAT 1 0.53 0.84 0
150 INT209987 Binding of APOE and LDLR 1 0.24 0 0
151 INT208349 Regulation of Binding of Apoc3 and Apoe 1 0.01 0.38 0
152 INT90283 Binding of APOE and Il1a 1 0.01 0 0
153 INT201080 Binding of APOE and HLA-C 1 0.41 0.31 0
154 INT353802 Binding of APOE and Apob 1 0.05 0.83 0
155 INT208355 Binding of Apoc3 and Apoe 1 0.01 0.76 0
156 INT198933 Binding of Apoe and App 1 0.33 0.19 0
157 INT169882 Rap2ip Positive_regulation of Gene_expression of MILR1 1 0.00 0.11 0
158 INT213049 Hdl1 Regulation of Gene_expression of Nppc 1 0.09 1 0
159 INT353801 Binding of APOE and Cd320 1 0.22 0.83 0
160 INT91095 Naf1 Positive_regulation of Npr1 1 0.01 0.18 0
161 INT250152 Binding of APOE and UBE4B 1 0.21 1.2 0
162 INT326059 APOA1 Positive_regulation of Gene_expression of APOE 1 0.61 0.38 0
163 INT191984 Ide Positive_regulation of Nppc 1 0.04 0.13 0
164 INT247031 Npr1 Positive_regulation of Prkaca 1 0.00 0 0
165 INT353804 Binding of APOE and Ldlr 1 0.16 0.84 0
166 INT326057 APOA1 Regulation of Localization of APOE 1 0.54 1.36 0
167 INT201082 Binding of APOE and HLA-B 1 0.54 1.54 0
168 INT91096 Naf1 Positive_regulation of Binding of Npr1 1 0.02 0.19 0
169 INT284093 VWF Negative_regulation of APOE 1 0.40 2.32 0
170 INT327809 Binding of ADORA2B and IL8 1 0.03 0.3 0
171 INT169881 Rap2ip Positive_regulation of Gene_expression of MMD 1 0.05 0.11 0
172 INT312769 Binding of Apoe and Pon1 1 0.04 0.86 0
173 INT353803 Binding of APOE and Hdl1 1 0.01 0.83 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for positive regulation of cGMP biosynthetic process. They are ordered first by their pain relevance and then by number of times they were reported in positive regulation of cGMP biosynthetic process. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT1303 Negative_regulation of Npr1 278 0.55 35.1 156.78
2 INT4259 Positive_regulation of Npr1 262 0.70 49.37 123.11
3 INT116861 Gene_expression of Apoe 182 0.78 100.41 27.26
4 INT7017 Regulation of Npr1 45 0.52 3.38 20.05
5 INT4260 Negative_regulation of Positive_regulation of Npr1 29 0.43 4.39 19.57
6 INT6461 Gene_expression of Npr1 35 0.75 10.38 17.58
7 INT125947 Gene_expression of Adora2b 57 0.75 23.69 17
8 INT9299 Positive_regulation of Positive_regulation of Npr1 32 0.53 6.65 16.72
9 INT216751 Gene_expression of ADORA2B 36 0.60 3.42 15.6
10 INT8989 Binding of Npr1 25 0.36 5.52 14.58
11 INT194850 Positive_regulation of Adora2b 43 0.61 20.57 13.89
12 INT13606 Negative_regulation of Negative_regulation of Npr1 13 0.40 1.21 10.01
13 INT26487 Positive_regulation of Npr1 17 0.70 10.01 8.78
14 INT216752 Binding of ADORA2B 17 0.36 0.76 7.36
15 INT197493 Localization of Apoe 61 0.79 27.48 7.06
16 INT142264 Positive_regulation of Apoe 47 0.50 26.35 6.94
17 INT26489 Negative_regulation of Npr1 15 0.59 5.7 6.79
18 INT182351 Positive_regulation of Gene_expression of Apoe 38 0.50 19.78 6.72
19 INT6459 Regulation of Negative_regulation of Npr1 10 0.53 0.16 6.44
20 INT7021 Positive_regulation of Negative_regulation of Npr1 8 0.22 1.02 6.36
21 INT6195 Transcription of Npr1 9 0.69 3 5.94
22 INT63042 Binding of Apoe 59 0.48 31.23 5.88
23 INT7018 Positive_regulation of Gene_expression of Npr1 10 0.59 5.09 5.66
24 INT13706 Localization of Npr1 10 0.59 0.83 5.42
25 INT216840 Binding of Adora2b 3 0.47 5.23 4.85
26 INT11064 Positive_regulation of NPR1 24 0.49 14.63 4.78
27 INT55758 Positive_regulation of Apoe 15 0.70 11.71 4.69
28 INT15033 Gene_expression of Apoe 18 0.78 14.97 3.75
29 INT104624 Negative_regulation of Apoe 26 0.59 19.25 3.71
30 INT157056 Gene_expression of Gucy1a2 4 0.09 0.71 3.67
31 INT224046 Negative_regulation of Adora2b 9 0.43 4 3.6
32 INT52047 Gene_expression of APOE 50 0.78 34.75 3.52
33 INT72141 Binding of Apoe 11 0.37 10.91 3.27
34 INT97710 Localization of Apoe 1 0.79 7.18 3.2
35 INT54449 Positive_regulation of Transcription of Npr1 3 0.45 1.73 2.81
36 INT99104 Gene_expression of Npr1 5 0.78 3.31 2.8
37 INT50080 Binding of APOE 38 0.45 29.61 2.67
38 INT97713 Negative_regulation of Apoe 4 0.59 4.57 2.52
39 INT26205 Positive_regulation of Positive_regulation of NPR1 3 0.24 1.57 2.52
40 INT80463 Localization of Gucy1a2 4 0.07 0.49 2.5
41 INT11065 Gene_expression of NPR1 6 0.55 3.41 2.32
42 INT208344 Positive_regulation of Localization of Apoe 22 0.48 9.6 2.27
43 INT142265 Regulation of Apoe 20 0.60 9.52 2.23
44 INT6460 Regulation of Gene_expression of Npr1 4 0.52 2.19 2.13
45 INT224047 Regulation of Adora2b 7 0.27 3.23 2.12
46 INT84060 Regulation of Apoe 4 0.62 3.33 2.05
47 INT216839 Positive_regulation of Positive_regulation of Adora2b 5 0.45 2.27 2
48 INT83218 Negative_regulation of Gucy1a2 6 0.24 0.82 1.9
49 INT14413 Regulation of Positive_regulation of Npr1 7 0.62 0.71 1.78
50 INT11098 Regulation of NPR1 5 0.37 1.39 1.74
51 INT216749 Positive_regulation of ADORA2B 6 0.37 0.89 1.72
52 INT55704 Positive_regulation of Gucy1a2 6 0.50 1.24 1.7
53 INT224049 Transcription of Adora2b 6 0.69 5.12 1.67
54 INT43045 Negative_regulation of Regulation of Npr1 3 0.12 0.17 1.65
55 INT96814 Negative_regulation of APOE 13 0.59 10.64 1.61
56 INT26488 Regulation of Npr1 4 0.39 0.88 1.56
57 INT216847 Transcription of ADORA2B 1 0.51 0.93 1.55
58 INT31921 Negative_regulation of Localization of Npr1 2 0.17 0 1.51
59 INT6194 Regulation of Transcription of Npr1 2 0.05 0.08 1.46
60 INT217388 Negative_regulation of Gene_expression of Apoe 11 0.59 6.07 1.4
61 INT67465 Positive_regulation of Regulation of Npr1 1 0.05 0.14 1.4
62 INT97716 Transcription of Apoe 3 0.53 2.61 1.36
63 INT97715 Regulation of Gene_expression of Apoe 3 0.62 1.98 1.23
64 INT113336 Positive_regulation of Gene_expression of Apoe 3 0.70 1.79 1.23
65 INT78355 Negative_regulation of Gene_expression of Npr1 2 0.06 0.15 1.22
66 INT11099 Localization of NPR1 5 0.67 1.49 1.21
67 INT89756 Positive_regulation of Positive_regulation of Npr1 2 0.47 0.9 1.19
68 INT40170 Regulation of Localization of Npr1 2 0.05 0.12 1.16
69 INT81136 Binding of Npr1 6 0.48 1.45 1.15
70 INT241724 Localization of Adora2b 2 0.75 1.21 1.14
71 INT224042 Phosphorylation of Adora2b 1 0.29 0.25 1.08
72 INT217390 Negative_regulation of Positive_regulation of Apoe 3 0.37 1.95 1.05
73 INT11100 Positive_regulation of Gene_expression of NPR1 2 0.37 1.49 0.98
74 INT97714 Negative_regulation of Localization of Apoe 1 0.58 1.83 0.97
75 INT217050 Positive_regulation of Gene_expression of Adora2b 3 0.50 1.19 0.92
76 INT11066 Negative_regulation of NPR1 5 0.27 0.89 0.88
77 INT72715 Positive_regulation of Nppc 4 0.39 1.55 0.87
78 INT42356 Negative_regulation of Binding of Npr1 1 0.32 0.37 0.82
79 INT32513 Regulation of Localization of NPR1 3 0.36 0.84 0.81
80 INT142597 Regulation of Binding of Apoe 1 0.34 2.21 0.8
81 INT80118 Gene_expression of NPPC 2 0.68 4.14 0.77
82 INT194851 Protein_catabolism of Adora2b 1 0.17 0.6 0.75
83 INT197495 Negative_regulation of Localization of Apoe 6 0.43 2.19 0.73
84 INT241715 Negative_regulation of Gene_expression of Adora2b 2 0.43 0.48 0.73
85 INT44612 Positive_regulation of APOE 16 0.67 5.73 0.72
86 INT54452 Regulation of Regulation of Npr1 1 0.03 0 0.72
87 INT5569 Phosphorylation of Npr1 3 0.18 0.61 0.7
88 INT270428 Negative_regulation of Binding of APOE 2 0.41 1.16 0.7
89 INT113335 Regulation of Transcription of Apoe 1 0.27 0.51 0.7
90 INT175580 Localization of APOE 10 0.76 18.84 0.65
91 INT70530 Binding of NPR1 3 0.17 0.71 0.65
92 INT252430 Negative_regulation of Binding of Adora2b 1 0.26 0.27 0.65
93 INT216750 Positive_regulation of Gene_expression of ADORA2B 1 0.34 0 0.64
94 INT216761 Positive_regulation of Binding of ADORA2B 1 0.34 0 0.63
95 INT97708 Regulation of Localization of Apoe 1 0.61 2.06 0.62
96 INT224056 Regulation of Gene_expression of Adora2b 2 0.27 0.12 0.59
97 INT89855 Localization of Npr1 1 0.20 0.32 0.57
98 INT84084 Binding of Gucy1a2 2 0.08 0.38 0.56
99 INT113334 Positive_regulation of Positive_regulation of Apoe 1 0.50 0.6 0.56
100 INT197322 Protein_catabolism of Apoe 6 0.71 3.52 0.51
101 INT216757 Protein_catabolism of ADORA2B 1 0.67 0 0.5
102 INT217370 Phosphorylation of Apoe 2 0.63 1.8 0.49
103 INT70532 Regulation of Regulation of NPR1 1 0.12 0.31 0.49
104 INT216753 Regulation of Binding of ADORA2B 1 0.18 0 0.48
105 INT312826 Negative_regulation of Nppc 1 0.03 1.36 0.45
106 INT96816 Regulation of APOE 8 0.45 6.62 0.44
107 INT65558 Regulation of Nppc 1 0.21 0.79 0.44
108 INT216855 Negative_regulation of ADORA2B 1 0.32 0.05 0.43
109 INT97712 Negative_regulation of Transcription of Apoe 1 0.43 1.05 0.4
110 INT72717 Gene_expression of Nppc 8 0.51 6.25 0.39
111 INT116066 Positive_regulation of Nppc 1 0.02 0.44 0.39
112 INT146994 Regulation of NPPC 2 0.22 1.46 0.37
113 INT70531 Negative_regulation of Negative_regulation of NPR1 1 0.19 0.24 0.37
114 INT252432 Positive_regulation of Localization of Adora2b 1 0.30 0.06 0.37
115 INT252431 Negative_regulation of Positive_regulation of Adora2b 1 0.26 0.76 0.35
116 INT42659 Positive_regulation of Localization of Npr1 1 0.10 0.36 0.34
117 INT131542 Negative_regulation of Gene_expression of APOE 6 0.40 3.92 0.33
118 INT32566 Positive_regulation of Localization of NPR1 1 0.58 0.17 0.33
119 INT170161 Localization of NPPC 2 0.62 2.06 0.32
120 INT80117 Positive_regulation of NPPC 3 0.61 0.6 0.31
121 INT311128 Positive_regulation of Regulation of Apoe 1 0.30 0.3 0.3
122 INT72112 Positive_regulation of Positive_regulation of Gucy1a2 1 0.07 0 0.3
123 INT175687 Transcription of Apoe 4 0.72 2.12 0.29
124 INT96815 Regulation of Gene_expression of APOE 2 0.62 1.1 0.29
125 INT242985 Regulation of Gene_expression of Npr1 1 0.03 0.85 0.29
126 INT149920 Regulation of Gucy1a2 1 0.11 0.35 0.28
127 INT97711 Positive_regulation of Transcription of Apoe 1 0.46 1.06 0.27
128 INT55703 Negative_regulation of Positive_regulation of Gucy1a2 1 0.31 0.28 0.27
129 INT254756 Regulation of Positive_regulation of Apoe 1 0.20 0.22 0.26
130 INT76401 Localization of Nppc 2 0.54 1.09 0.24
131 INT80465 Regulation of Localization of Gucy1a2 1 0.03 0.49 0.23
132 INT170164 Regulation of Gene_expression of NPPC 1 0.37 0.94 0.23
133 INT331632 Localization of Rap2ip 1 0.40 1.09 0.22
134 INT323964 Negative_regulation of Binding of Apoe 1 0.39 0.35 0.22
135 INT198892 Regulation of Binding of Apoe 6 0.45 2.94 0.21
136 INT193810 Phosphorylation of APOE 2 0.27 1.13 0.2
137 INT170162 Negative_regulation of Localization of NPPC 1 0.35 0.64 0.2
138 INT41153 Regulation of Binding of Npr1 1 0.01 0 0.19
139 INT224051 Regulation of Phosphorylation of Adora2b 1 0.09 0.09 0.18
140 INT89848 Positive_regulation of Localization of Npr1 1 0.13 0.15 0.18
141 INT76402 Gene_expression of Nppc 2 0.30 1.8 0.17
142 INT254754 Regulation of Localization of Apoe 1 0.20 0.39 0.17
143 INT224055 Negative_regulation of Phosphorylation of Adora2b 1 0.15 0 0.16
144 INT254755 Positive_regulation of Transcription of Apoe 1 0.16 0.41 0.16
145 INT224054 Positive_regulation of Phosphorylation of Adora2b 1 0.17 0 0.16
146 INT96772 Positive_regulation of Gene_expression of APOE 5 0.66 5.44 0.14
147 INT198894 Regulation of Gene_expression of Apoe 2 0.44 0.56 0.14
148 INT104623 Regulation of Negative_regulation of Apoe 2 0.45 0.73 0.12
149 INT326081 Negative_regulation of Localization of APOE 1 0.56 2.23 0.11
150 INT54547 Positive_regulation of Phosphorylation of Npr1 1 0.05 0 0.1
151 INT300643 Positive_regulation of Binding of APOE 1 0.44 0.8 0.09
152 INT252433 Regulation of Positive_regulation of Adora2b 1 0.44 0 0.09
153 INT44609 Negative_regulation of Positive_regulation of APOE 1 0.16 0.9 0.09
154 INT257197 Phosphorylation of Npr1 1 0.03 0 0.08
155 INT205147 Regulation of Phosphorylation of APOE 1 0.06 0.34 0.07
156 INT97709 Positive_regulation of Localization of Apoe 1 0.68 1.02 0.07
157 INT175695 Positive_regulation of Gene_expression of Nppc 1 0.06 1.06 0.07
158 INT125747 Positive_regulation of Gene_expression of Npr1 1 0.70 0.62 0.07
159 INT241716 Positive_regulation of Transcription of Adora2b 1 0.50 0.28 0.06
160 INT31800 Positive_regulation of Binding of Npr1 1 0.08 0.06 0.06
161 INT208336 Positive_regulation of Binding of Apoe 1 0.48 0.7 0.05
162 INT208333 Positive_regulation of Positive_regulation of Apoe 1 0.48 0.65 0.05
163 INT326070 Regulation of Localization of APOE 1 0.58 1.21 0.03
164 INT191285 Positive_regulation of Localization of APOE 3 0.66 3.06 0
165 INT326073 Transcription of APOE 2 0.51 1.94 0
166 INT50081 Positive_regulation of Positive_regulation of APOE 2 0.49 0.18 0
167 INT72716 Localization of Nppc 2 0.06 0.29 0
168 INT191976 Binding of Nppc 1 0.03 0.09 0
169 INT191975 Positive_regulation of Gene_expression of Nppc 1 0.03 0.09 0
170 INT212976 Negative_regulation of Gene_expression of Nppc 1 0.21 1.03 0
171 INT72714 Negative_regulation of Localization of Nppc 1 0.02 0.05 0
172 INT327819 Localization of ADORA2B 1 0.22 0.3 0
173 INT274107 Negative_regulation of Phosphorylation of Npr1 1 0.08 0.32 0
174 INT314770 Regulation of Nppc 1 0.00 0.77 0
175 INT191972 Positive_regulation of Localization of Nppc 1 0.03 0.15 0
176 INT326524 Negative_regulation of Transcription of APOE 1 0.30 1.71 0
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