GO:0030836

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Name positive regulation of actin filament depolymerization
Categary Process
Go Slim No
Go Link GO:0030836
Unique Molecular Interactions 79
Total Molecular Interactions 116
Total Single Events 919
Pain Genes Associated 8

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for positive regulation of actin filament depolymerization. They are ordered first by their pain relevance and then by number of times they were reported for positive regulation of actin filament depolymerization. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT327940 Crh Positive_regulation of Gene_expression of F2rl1 1 0.44 5.57 2.5
2 INT96652 F2rl1 Positive_regulation of Tac1 1 0.47 2.62 2.25
3 INT229394 TPSD1 Positive_regulation of F2RL1 2 0.00 3.11 2.14
4 INT107858 PRSS1 Positive_regulation of F2RL1 6 0.12 4.23 1.29
5 INT181490 Tryptase Positive_regulation of F2rl1 1 0.13 1.83 1.21
6 INT156238 Binding of F2rl1 and Tnfsf14 1 0.08 2.85 1.08
7 INT162319 Positive_regulation of F2rl1 Positive_regulation of Il1b 1 0.46 1.6 1.04
8 INT124918 Binding of PLEK and Maob 1 0.10 1.05 0.98
9 INT119100 Positive_regulation of F2rl1 Positive_regulation of Positive_regulation of Ptgs1 1 0.03 0.56 0.9
10 INT126268 Tpsab1 Positive_regulation of F2rl1 2 0.35 1.65 0.88
11 INT196638 TNF Positive_regulation of F2RL1 2 0.09 1.52 0.84
12 INT196632 IL1B Positive_regulation of F2RL1 2 0.05 1.52 0.84
13 INT335644 CTSB Positive_regulation of F2RL1 1 0.02 2.58 0.82
14 INT156239 Tnfsf14 Positive_regulation of F2rl1 1 0.09 2.4 0.81
15 INT124292 Binding of Trpv1 and F2rl1 1 0.46 1.1 0.81
16 INT262582 F2rl1 Regulation of Positive_regulation of Prkca 1 0.03 0.58 0.78
17 INT262562 F2rl1 Regulation of Trpv1 1 0.12 0.58 0.77
18 INT224463 TPSAB1 Positive_regulation of F2RL1 2 0.03 1.49 0.76
19 INT259556 PLEK Negative_regulation of Gene_expression of VEGFA 1 0.46 2.15 0.73
20 INT259557 PLEK Negative_regulation of Positive_regulation of VEGFA 1 0.46 2.15 0.73
21 INT341534 INSRR Positive_regulation of F2RL1 1 0.00 1.4 0.7
22 INT81968 Binding of PLEK and Adra2a 1 0.07 0.1 0.7
23 INT252857 Binding of F2rl1 and Trpa1 1 0.22 0.84 0.63
24 INT138332 Binding of P2rx3 and F2rl1 1 0.35 0.25 0.59
25 INT112312 tryptase Positive_regulation of F2rl1 2 0.08 0.23 0.57
26 INT100726 TNF Positive_regulation of Gene_expression of F2RL1 2 0.27 1.9 0.46
27 INT312813 Binding of F2rl1 and Tpsab1 1 0.01 0.26 0.46
28 INT156234 Tnfsf14 Positive_regulation of Transcription of F2rl1 1 0.09 1.26 0.42
29 INT156233 Positive_regulation of Tnfsf14 Positive_regulation of F2rl1 1 0.09 1.15 0.4
30 INT310600 Tbxa2r Positive_regulation of PLEK 1 0.53 0.45 0.38
31 INT139566 Binding of PLEK and Tbxa2r 1 0.01 1.14 0.38
32 INT188427 IL6 Positive_regulation of Pdxp 1 0.00 0.84 0.38
33 INT150333 4930519F16Rik Positive_regulation of F2rl1 1 0.00 0.67 0.38
34 INT224461 F2RL1 Positive_regulation of CALCRL 1 0.00 0.37 0.31
35 INT224462 Positive_regulation of F2RL1 Positive_regulation of MMP1 1 0.10 0.47 0.28
36 INT292570 Binding of F2RL1 and HTR1A 1 0.07 0.8 0.28
37 INT292568 Binding of F2RL1 and MRGPRX1 1 0.07 0.81 0.28
38 INT292571 Positive_regulation of F2RL1 Positive_regulation of Localization of IL6 1 0.07 0.8 0.27
39 INT292563 F2RL1 Negative_regulation of TNF 1 0.15 0.73 0.25
40 INT341538 F2 Positive_regulation of F2RL1 1 0.02 0.68 0.24
41 INT329409 Binding of SPTLC1 and Dstn 1 0.05 1.3 0.23
42 INT292556 Binding of F2RL1 and TLR4 1 0.05 0.52 0.22
43 INT292557 Binding of F2RL1 and MYD88 1 0.08 0.52 0.22
44 INT139565 Negative_regulation of Binding of PLEK and Tbxa2r 1 0.01 0.57 0.19
45 INT207151 PLA2G6 Positive_regulation of Localization of F2rl1 1 0.16 0.73 0.18
46 INT341531 F2RL1 Regulation of CD55 1 0.33 0.41 0.18
47 INT207147 Pla2g1b Positive_regulation of Localization of F2rl1 1 0.03 0.73 0.18
48 INT293698 Positive_regulation of Binding of Akt1 and Plek 1 0.05 0.12 0.15
49 INT293695 Binding of Akt1 and Plek 1 0.03 0.12 0.15
50 INT293699 Regulation of Binding of Akt1 and Plek 1 0.04 0.12 0.15
51 INT105253 Positive_regulation of Binding of Rnpep and F2rl1 1 0.02 0 0.15
52 INT105252 Binding of Rnpep and F2rl1 1 0.01 0 0.15
53 INT341529 PRSS1 Positive_regulation of Gene_expression of F2RL1 1 0.06 0 0.11
54 INT265919 Binding of PLEK and Adp 1 0.01 0.38 0.11
55 INT341543 PRSS1 Positive_regulation of Transcription of F2RL1 1 0.06 0 0.11
56 INT292569 F2RL1 Positive_regulation of Negative_regulation of MAPK8 1 0.22 0 0.08
57 INT61385 FANCB Negative_regulation of PLEK 1 0.42 0.13 0.07
58 INT213060 Hdl1 Negative_regulation of Gene_expression of PLEK 1 0.25 1.33 0.05
59 INT341535 F2RL1 Positive_regulation of Gene_expression of THBS1 1 0.28 0.75 0.04
60 INT347465 Binding of PLEK and ST7L 1 0.01 0 0.04
61 INT175631 F2RL1 Positive_regulation of Positive_regulation of MMP1 1 0.08 0.69 0.04
62 INT105260 4930519F16Rik Positive_regulation of F2rl1 1 0.00 0 0.03
63 INT175628 F2R Positive_regulation of F2RL1 1 0.04 1.46 0.03
64 INT341537 F2RL1 Positive_regulation of TSC1 1 0.01 0.76 0.03
65 INT308131 PLEK Positive_regulation of F2 1 0.12 0.08 0
66 INT249151 Binding of Cfl1 and Was 1 0.01 0.18 0
67 INT281320 Binding of PLEK and St8sia2 1 0.06 0.38 0
68 INT281322 Binding of PLEK and Tlr4 1 0.15 1.41 0
69 INT286682 Maob Positive_regulation of Positive_regulation of PLEK 1 0.51 0.89 0
70 INT354487 Binding of F9 and PLEK 1 0.52 0.14 0
71 INT340380 Binding of Cfl1 and Clcn4-2 1 0.13 0.82 0
72 INT275985 Binding of PLEK and Gp6 1 0.29 0 0
73 INT270084 Binding of PLEK and PSMG1 1 0.09 0.26 0
74 INT340378 Binding of Cfl1 and Clcn5 1 0.15 0.82 0
75 INT341540 Positive_regulation of F2RL1 Positive_regulation of Gene_expression of AREG 1 0.18 0.51 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for positive regulation of actin filament depolymerization. They are ordered first by their pain relevance and then by number of times they were reported in positive regulation of actin filament depolymerization. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT100733 Positive_regulation of F2RL1 62 0.70 59.14 35.22
2 INT9296 Negative_regulation of PLEK 100 0.57 36.65 27.52
3 INT94658 Positive_regulation of F2rl1 51 0.70 33.65 27.46
4 INT90849 Gene_expression of F2rl1 55 0.78 31.31 20.65
5 INT100732 Gene_expression of F2RL1 55 0.78 38.89 19.45
6 INT104674 Positive_regulation of F2rl1 35 0.65 27.76 14.16
7 INT12135 Gene_expression of PLEK 62 0.75 34.13 12.47
8 INT18412 Binding of PLEK 49 0.47 17.82 10.72
9 INT3366 Localization of PLEK 44 0.78 15.83 9.55
10 INT10969 Positive_regulation of PLEK 33 0.67 16.96 8.35
11 INT12975 Regulation of PLEK 21 0.60 13.62 8.28
12 INT103791 Positive_regulation of Positive_regulation of F2rl1 10 0.50 11.24 7.41
13 INT118516 Positive_regulation of Positive_regulation of F2RL1 7 0.49 4.63 6.33
14 INT90848 Localization of F2rl1 23 0.80 3.15 5.2
15 INT105256 Positive_regulation of Gene_expression of F2rl1 6 0.68 10.09 4.83
16 INT107860 Positive_regulation of Gene_expression of F2RL1 10 0.68 6.36 3.88
17 INT100729 Localization of F2RL1 7 0.75 5.29 3.37
18 INT224481 Regulation of F2RL1 4 0.37 5.07 2.74
19 INT161942 Regulation of Gene_expression of F2RL1 12 0.62 4.84 2.73
20 INT111017 Regulation of F2rl1 3 0.22 0 2.61
21 INT30001 Negative_regulation of Gene_expression of PLEK 8 0.57 3.31 2.47
22 INT111016 Gene_expression of F2rl1 11 0.73 3.58 2.37
23 INT138331 Binding of F2rl1 4 0.36 1.92 2.32
24 INT114433 Positive_regulation of Positive_regulation of F2rl1 4 0.49 3.5 2.29
25 INT224480 Binding of F2RL1 5 0.36 5.2 2.19
26 INT111018 Binding of F2rl1 5 0.30 3.11 2.02
27 INT224496 Negative_regulation of F2RL1 3 0.48 1.85 1.97
28 INT33393 Positive_regulation of Gene_expression of PLEK 9 0.67 7.35 1.65
29 INT96651 Negative_regulation of F2rl1 4 0.37 2.26 1.4
30 INT228036 Negative_regulation of Cfl1 1 0.09 1.1 1.34
31 INT119743 Negative_regulation of Positive_regulation of F2rl1 3 0.43 1.97 1.3
32 INT80086 Regulation of Gene_expression of PLEK 5 0.60 2.79 1.29
33 INT327936 Regulation of Gene_expression of F2rl1 1 0.61 2.62 1.26
34 INT30002 Negative_regulation of Negative_regulation of PLEK 3 0.42 0.76 1.12
35 INT224494 Regulation of Positive_regulation of F2RL1 4 0.37 1.67 1.11
36 INT159330 Positive_regulation of Localization of F2rl1 1 0.49 0.34 1.02
37 INT112311 Regulation of F2rl1 2 0.27 0.73 0.97
38 INT224489 Negative_regulation of Gene_expression of F2RL1 3 0.57 1.51 0.96
39 INT101495 Regulation of Positive_regulation of F2rl1 1 0.26 0.88 0.91
40 INT81220 Negative_regulation of Binding of PLEK 5 0.42 2.03 0.84
41 INT36881 Regulation of Positive_regulation of PLEK 2 0.44 1.77 0.84
42 INT18413 Positive_regulation of Binding of PLEK 3 0.49 1.06 0.77
43 INT3368 Positive_regulation of Localization of PLEK 3 0.45 0.51 0.77
44 INT292595 Negative_regulation of Positive_regulation of F2RL1 3 0.40 1.29 0.63
45 INT100730 Positive_regulation of Localization of F2RL1 2 0.49 0.99 0.62
46 INT42121 Negative_regulation of Localization of PLEK 4 0.42 1.92 0.61
47 INT297831 Protein_catabolism of F2rl1 2 0.10 0.5 0.6
48 INT45916 Regulation of Negative_regulation of PLEK 1 0.44 0 0.54
49 INT124290 Negative_regulation of Gene_expression of F2rl1 3 0.42 1.48 0.52
50 INT3367 Regulation of Localization of PLEK 1 0.44 0.34 0.52
51 INT111019 Negative_regulation of Binding of F2rl1 1 0.35 0 0.48
52 INT182136 Regulation of Regulation of PLEK 1 0.44 0.4 0.44
53 INT156226 Transcription of F2rl1 1 0.23 1.25 0.41
54 INT166066 Negative_regulation of Localization of F2rl1 1 0.43 0.47 0.4
55 INT156230 Positive_regulation of Binding of F2rl1 1 0.21 1.11 0.4
56 INT112310 Negative_regulation of Regulation of F2rl1 1 0.03 0 0.39
57 INT323021 Positive_regulation of Regulation of PLEK 1 0.49 0.58 0.37
58 INT292591 Negative_regulation of Negative_regulation of F2RL1 1 0.35 0 0.36
59 INT44345 Positive_regulation of Negative_regulation of PLEK 1 0.45 0.05 0.35
60 INT207078 Gene_expression of Cfl1 1 0.16 0.85 0.34
61 INT207066 Localization of Cfl1 1 0.18 0.83 0.33
62 INT188420 Positive_regulation of Pdxp 1 0.04 0.8 0.32
63 INT19700 Positive_regulation of Protein_catabolism of PLEK 1 0.49 0.59 0.3
64 INT19699 Protein_catabolism of PLEK 1 0.86 0.58 0.29
65 INT224491 Transcription of F2RL1 1 0.68 0.31 0.26
66 INT94657 Transcription of F2rl1 1 0.69 0.5 0.26
67 INT105257 Regulation of Localization of F2rl1 1 0.23 0 0.26
68 INT329398 Binding of Dstn 1 0.13 1.3 0.23
69 INT42592 Negative_regulation of Transcription of PLEK 1 0.41 0 0.21
70 INT42593 Transcription of PLEK 1 0.67 0 0.2
71 INT157288 Positive_regulation of Cfl1 2 0.45 1.49 0.19
72 INT329401 Regulation of Negative_regulation of Dstn 1 0.13 1.4 0.18
73 INT207129 Localization of F2rl1 1 0.22 0.72 0.18
74 INT108192 Regulation of Binding of PLEK 1 0.60 0.17 0.17
75 INT329400 Negative_regulation of Dstn 1 0.13 1.34 0.17
76 INT157287 Positive_regulation of Phosphorylation of Cfl1 1 0.11 0.41 0.15
77 INT157285 Phosphorylation of Cfl1 1 0.18 0.41 0.15
78 INT292590 Positive_regulation of Negative_regulation of F2RL1 1 0.38 0 0.15
79 INT16719 Positive_regulation of Positive_regulation of PLEK 1 0.45 0.13 0.14
80 INT341581 Positive_regulation of Transcription of F2RL1 1 0.44 0 0.11
81 INT292586 Phosphorylation of F2RL1 1 0.51 0 0.07
82 INT292582 Negative_regulation of Phosphorylation of F2RL1 1 0.35 0 0.07
83 INT149028 Positive_regulation of Gene_expression of F2rl1 1 0.43 0 0
84 INT180099 Binding of Plek 1 0.02 0 0
85 INT149032 Regulation of Gene_expression of F2rl1 1 0.23 0 0
86 INT292596 Positive_regulation of Binding of F2RL1 1 0.41 0 0
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