GO:0030851

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Name granulocyte differentiation
Categary Process
Go Slim No
Go Link GO:0030851
Unique Molecular Interactions 86
Total Molecular Interactions 138
Total Single Events 1165
Pain Genes Associated 10

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for granulocyte differentiation. They are ordered first by their pain relevance and then by number of times they were reported for granulocyte differentiation. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT200322 Binding of Rest and Sp3 1 0.39 2.93 3.98
2 INT117008 Sfpi1 Regulation of Oprm1 1 0.56 0.56 1.49
3 INT200323 Binding of Oprm1 and Sp3 1 0.39 0 0.99
4 INT117005 Sfpi1 Positive_regulation of Oprm1 1 0.52 0.56 0.94
5 INT122350 Ngf Regulation of Hsd3b1 1 0.34 0 0.87
6 INT48380 CSF3 Regulation of Gene_expression of SELL 1 0.41 0.4 0.83
7 INT98951 Positive_regulation of Binding of NR5A2 and SP3 1 0.00 0 0.7
8 INT98957 Binding of NR5A2 and SP3 1 0.00 0 0.7
9 INT284040 Gtf3a Positive_regulation of Csf3 1 0.01 1.7 0.7
10 INT117007 Binding of Oprm1 and Sfpi1 1 0.50 0.07 0.63
11 INT98955 Positive_regulation of Binding of SP3 and CFHR4 1 0.00 0 0.62
12 INT98952 Binding of SP3 and CFHR4 1 0.00 0 0.61
13 INT200348 Sp3 Negative_regulation of Gene_expression of Oprm1 1 0.48 0.4 0.55
14 INT117006 Sfpi1 Negative_regulation of Oprm1 1 0.39 0.29 0.49
15 INT48388 CSF3 Regulation of Gene_expression of ITGAM 1 0.35 0.2 0.44
16 INT48389 CSF3 Regulation of Gene_expression of ITGB2 1 0.25 0.2 0.44
17 INT89332 Binding of SP1 and SP3 1 0.30 0.76 0.39
18 INT200313 Sp3 Regulation of Oprm1 1 0.10 0.07 0.38
19 INT200301 Sp3 Regulation of Rorb 1 0.00 0.07 0.38
20 INT284308 Mir155 Regulation of Gene_expression of Csf3 1 0.36 0.8 0.36
21 INT187064 ARSD Negative_regulation of CYP19A1 1 0.22 0.7 0.35
22 INT167551 Binding of MECP2 and SP3 1 0.01 0.06 0.35
23 INT175330 IL6 Positive_regulation of Gene_expression of CYP19A1 1 0.01 0.97 0.32
24 INT253576 Binding of Lpl and Sp3 1 0.22 0.85 0.32
25 INT222299 Binding of CYP19A1 and AIS 2 0.25 1.65 0.31
26 INT134927 CYP19A1 Positive_regulation of Gene_expression of MME 1 0.30 1.04 0.28
27 INT134930 MME Positive_regulation of Gene_expression of CYP19A1 1 0.30 1.04 0.28
28 INT96788 Binding of SP3 and NR2F2 1 0.24 0.27 0.27
29 INT96790 SP3 Positive_regulation of GDF15 1 0.20 0.26 0.27
30 INT114389 Csf3 Negative_regulation of Localization of Tnf 1 0.02 0.46 0.26
31 INT114388 Csf3 Negative_regulation of Tnf 1 0.02 0.46 0.25
32 INT114390 Regulation of Csf3 Negative_regulation of Tnf 1 0.02 0.46 0.25
33 INT199970 CYP19A1 Positive_regulation of Gene_expression of ESR1 1 0.06 0.72 0.25
34 INT200309 Positive_regulation of Binding of Rest and Sp3 1 0.41 0.88 0.24
35 INT253568 Negative_regulation of Binding of Lpl and Sp3 1 0.19 0.37 0.22
36 INT145140 Negative_regulation of CPOX Negative_regulation of Gene_expression of CYP19A1 1 0.13 0.47 0.2
37 INT115142 TGM7 Positive_regulation of Gene_expression of CITED2 1 0.02 0.45 0.2
38 INT284305 Mir155 Regulation of Csf3 1 0.19 0.29 0.18
39 INT200328 Sp3 Positive_regulation of Gene_expression of Oprm1 1 0.38 0 0.13
40 INT200315 Binding of Sp1 and Sp3 1 0.29 0 0.12
41 INT277988 Csf3 Positive_regulation of Epc1 1 0.00 0.51 0.11
42 INT277987 Regulation of Csf3 Positive_regulation of Epc1 1 0.00 0.51 0.11
43 INT200320 Binding of Sp3 and Negative_regulation of Gene_expression of Oprm1 1 0.35 0.4 0.1
44 INT210992 Binding of KCNMA1 and SP3 1 0.00 0.17 0.1
45 INT210989 Binding of FSCN1 and SP3 1 0.00 0.17 0.1
46 INT210988 Binding of SP3 and PKDREJ 1 0.01 0.17 0.1
47 INT210994 Binding of SEA and SP3 1 0.00 0.17 0.1
48 INT220394 MRXS5 Positive_regulation of Gene_expression of CYP19A1 1 0.00 0.89 0.09
49 INT285070 CCL16 Positive_regulation of Gene_expression of CYP19A1 1 0.02 0.69 0.09
50 INT220412 Cpox Positive_regulation of Gene_expression of CYP19A1 1 0.01 0.9 0.09
51 INT284301 Mir155 Positive_regulation of Regulation of Csf3 1 0.55 0.1 0.09
52 INT184108 Csf3 Positive_regulation of Mapk1 1 0.09 0.64 0.08
53 INT261262 AIS Negative_regulation of Cyp19a1 1 0.01 0.2 0.08
54 INT184119 Socs3 Negative_regulation of Csf3 1 0.21 0.64 0.08
55 INT213933 AR Negative_regulation of Cyp19a1 1 0.07 0.79 0.07
56 INT253570 Binding of Csnk2a2 and Sp3 1 0.16 0.2 0.07
57 INT293494 Sfpi1 Regulation of Negative_regulation of Hsp90aa1 1 0.04 0.23 0.05
58 INT187732 Binding of CYP19A1 and Cyp11a1 1 0.01 0.68 0.04
59 INT213262 IL6 Positive_regulation of CYP19A1 1 0.11 1.63 0.03
60 INT254282 Sfpi1 Positive_regulation of Binding of Pam16 1 0.02 0.23 0.03
61 INT253574 Sp3 Positive_regulation of Lpl 1 0.22 0 0.03
62 INT254285 Sfpi1 Positive_regulation of Gene_expression of THPO 1 0.02 0.17 0.03
63 INT187676 Binding of CYP19A1 and SHBG 1 0.01 0.63 0.03
64 INT133804 Binding of CYP2B6 and CYP19A1 3 0.09 2.26 0
65 INT176564 Binding of Cyp17a1 and Cyp19a1 1 0.03 0.33 0
66 INT350120 FSHR Regulation of CYP19A1 1 0.01 3.02 0
67 INT284296 Mir155 Regulation of Spi1 1 0.25 0.36 0
68 INT293492 Hsp90aa1 Regulation of Gene_expression of Sfpi1 1 0.04 0.1 0
69 INT242176 AIS Negative_regulation of CYP19A1 1 0.07 0.69 0
70 INT331861 Binding of Csf3 and Mst1r 1 0.08 0 0
71 INT331867 Binding of Csf3 and Mest 1 0.08 0 0
72 INT350715 Sfpi1 Positive_regulation of Transcription of MIR424 1 0.09 0.25 0
73 INT187674 FSHR Positive_regulation of Gene_expression of CYP19A1 1 0.24 0 0
74 INT24894 CSF3 Regulation of CSF2 1 0.32 0.17 0
75 INT331869 Positive_regulation of Binding of Csf3 and Mst1r 1 0.11 0 0
76 INT331862 Positive_regulation of Binding of Csf3 and Mest 1 0.11 0 0
77 INT242178 CYP19A1 Regulation of Cyp11a1 1 0.01 0.35 0
78 INT176569 Binding of FSHR and Cyp19a1 1 0.04 0.06 0
79 INT304168 Binding of Gata1 and Sfpi1 1 0.08 0.07 0
80 INT242179 Cyp11a1 Regulation of CYP19A1 1 0.01 0.7 0
81 INT187670 Gene_expression of FSHR Positive_regulation of Gene_expression of CYP19A1 1 0.16 0 0
82 INT253567 Binding of Pik3r1 and Sp3 1 0.11 0.06 0
83 INT292139 SP3 Positive_regulation of Transcription of HIVEP1 1 0.02 0.42 0
84 INT350705 Sfpi1 Positive_regulation of Mir223 1 0.04 0.13 0
85 INT277622 Esr1 Positive_regulation of Gene_expression of Cyp19a1 1 0.03 1.37 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for granulocyte differentiation. They are ordered first by their pain relevance and then by number of times they were reported in granulocyte differentiation. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT71047 Gene_expression of CYP19A1 122 0.78 68.78 22.21
2 INT14724 Negative_regulation of CYP19A1 233 0.59 96.56 18.26
3 INT8801 Gene_expression of Csf3 71 0.74 45.6 10.83
4 INT10597 Gene_expression of Cyp19a1 27 0.78 7.48 9.11
5 INT119904 Regulation of CYP19A1 25 0.62 9.36 8.34
6 INT48626 Positive_regulation of Csf3 33 0.66 29.79 7.34
7 INT135760 Regulation of Gene_expression of Cyp19a1 2 0.62 1.15 5.81
8 INT23010 Positive_regulation of CYP19A1 28 0.58 24.18 5.37
9 INT117004 Gene_expression of Sfpi1 21 0.75 15.95 5.29
10 INT198736 Binding of Sp3 23 0.40 4.77 4.42
11 INT10824 Negative_regulation of Cyp19a1 38 0.57 25.18 3.56
12 INT24926 Regulation of Csf3 17 0.52 10.41 3.04
13 INT116376 Transcription of Cyp19a1 2 0.40 0.74 3.04
14 INT133809 Negative_regulation of Gene_expression of CYP19A1 9 0.43 7.67 2.99
15 INT113277 Positive_regulation of Gene_expression of CYP19A1 13 0.69 10.23 2.97
16 INT89336 Binding of SP3 6 0.47 1.75 2.63
17 INT15187 Positive_regulation of Gene_expression of Csf3 17 0.66 10.97 2.51
18 INT102659 Gene_expression of CSF3 32 0.77 21.93 2.39
19 INT71048 Transcription of CYP19A1 11 0.72 8.74 2.24
20 INT111113 Binding of CYP19A1 15 0.36 9.17 2.12
21 INT48444 Localization of Csf3 28 0.72 14.85 2.11
22 INT342803 Positive_regulation of Transcription of Cyp19a1 1 0.30 0.33 2.08
23 INT81347 Regulation of Cyp19a1 7 0.40 2.1 1.94
24 INT122346 Gene_expression of Hsd3b1 1 0.75 0 1.78
25 INT117003 Binding of Sfpi1 5 0.47 5.04 1.74
26 INT48141 Binding of Csf3 18 0.39 9.93 1.71
27 INT10596 Positive_regulation of Cyp19a1 10 0.42 2.08 1.62
28 INT28714 Negative_regulation of Csf3 10 0.41 6.9 1.6
29 INT136459 Gene_expression of Sp3 6 0.64 1.97 1.47
30 INT127889 Regulation of Gene_expression of CYP19A1 11 0.62 6.7 1.41
31 INT122345 Positive_regulation of Gene_expression of Hsd3b1 1 0.49 0 1.34
32 INT117002 Negative_regulation of Sfpi1 16 0.58 9.72 1
33 INT122347 Transcription of Hsd3b1 1 0.52 0 0.99
34 INT136458 Negative_regulation of Sp3 3 0.39 1.53 0.93
35 INT79344 Binding of Cyp19a1 4 0.33 0.61 0.8
36 INT161339 Localization of Cyp19a1 1 0.73 1.32 0.71
37 INT148291 Positive_regulation of CSF3 9 0.61 6.37 0.7
38 INT284272 Regulation of Gene_expression of Csf3 1 0.52 1.21 0.67
39 INT141894 Localization of CSF3 9 0.62 5.5 0.64
40 INT171105 Positive_regulation of Positive_regulation of CYP19A1 5 0.39 4.02 0.58
41 INT211164 Regulation of Positive_regulation of Csf3 3 0.38 3.18 0.55
42 INT353896 Negative_regulation of Phosphorylation of Cyp19a1 1 0.22 0.47 0.55
43 INT353893 Phosphorylation of Cyp19a1 1 0.31 0.46 0.55
44 INT284259 Positive_regulation of Negative_regulation of Csf3 2 0.48 0.79 0.54
45 INT71046 Localization of CYP19A1 2 0.78 1.38 0.48
46 INT200264 Localization of Sp3 1 0.62 0 0.47
47 INT122348 Regulation of Hsd3b1 1 0.60 0 0.46
48 INT253558 Negative_regulation of Binding of Sp3 1 0.39 1.09 0.46
49 INT187717 Regulation of Negative_regulation of CYP19A1 11 0.42 2.85 0.45
50 INT127890 Positive_regulation of Negative_regulation of CYP19A1 6 0.50 1.41 0.45
51 INT284268 Negative_regulation of Positive_regulation of Csf3 1 0.49 1.43 0.45
52 INT84915 Negative_regulation of Gene_expression of Cyp19a1 2 0.15 1.29 0.42
53 INT98969 Regulation of Binding of SP3 1 0.26 0 0.41
54 INT89333 Negative_regulation of SP3 1 0.38 0.77 0.39
55 INT89335 Negative_regulation of Binding of SP3 1 0.38 0.77 0.39
56 INT181025 Localization of Sfpi1 3 0.80 4.96 0.38
57 INT284270 Positive_regulation of Regulation of Csf3 1 0.39 0.88 0.37
58 INT98960 Positive_regulation of Binding of SP3 1 0.67 0 0.37
59 INT181122 Positive_regulation of Gene_expression of Cyp19a1 1 0.02 0.68 0.36
60 INT84555 Negative_regulation of Spi1 6 0.42 0.71 0.34
61 INT200265 Regulation of Sp3 2 0.37 0.25 0.34
62 INT209323 Positive_regulation of Transcription of CYP19A1 5 0.32 4.22 0.33
63 INT181020 Positive_regulation of Gene_expression of Sfpi1 2 0.67 1.11 0.31
64 INT227332 Phosphorylation of Csf3 2 0.43 2.01 0.31
65 INT284275 Regulation of Transcription of Csf3 1 0.33 1.01 0.29
66 INT284258 Transcription of Csf3 1 0.51 1 0.29
67 INT181051 Transcription of Sfpi1 1 0.62 1.1 0.29
68 INT200276 Positive_regulation of Sp3 1 0.42 0.17 0.28
69 INT51375 Negative_regulation of Regulation of Csf3 2 0.36 0.91 0.27
70 INT212362 Positive_regulation of Gene_expression of CSF3 3 0.32 4.85 0.26
71 INT200251 Phosphorylation of Sp3 2 0.67 0.42 0.24
72 INT161757 Negative_regulation of CSF3 3 0.59 2.36 0.23
73 INT101308 Positive_regulation of Spi1 2 0.67 0.38 0.23
74 INT181036 Positive_regulation of Sfpi1 3 0.49 0.96 0.21
75 INT115160 Gene_expression of CITED2 1 0.04 0.45 0.2
76 INT115153 Positive_regulation of Gene_expression of CITED2 1 0.02 0.45 0.2
77 INT136452 Negative_regulation of Negative_regulation of Sp3 1 0.28 0.65 0.2
78 INT175360 Regulation of Transcription of CYP19A1 1 0.04 1 0.19
79 INT101309 Gene_expression of Spi1 2 0.75 0.64 0.18
80 INT101307 Positive_regulation of Gene_expression of Spi1 1 0.67 0.28 0.18
81 INT106451 Regulation of Spi1 1 0.43 0 0.18
82 INT24715 Regulation of CSF3 3 0.38 0.9 0.16
83 INT284284 Negative_regulation of Gene_expression of Csf3 1 0.36 0.33 0.16
84 INT136454 Positive_regulation of Gene_expression of Sp3 1 0.33 0.44 0.16
85 INT181033 Regulation of Sfpi1 2 0.40 1.58 0.13
86 INT200261 Positive_regulation of Transcription of Sp3 1 0.42 0 0.13
87 INT200280 Transcription of Sp3 1 0.57 0 0.13
88 INT200268 Positive_regulation of Binding of Sp3 2 0.39 0.8 0.1
89 INT14302 Binding of CSF3 6 0.33 3.09 0.09
90 INT152037 Regulation of Localization of Csf3 1 0.18 0.74 0.09
91 INT253546 Positive_regulation of Phosphorylation of Sp3 1 0.29 0.42 0.09
92 INT211005 Gene_expression of SP3 1 0.03 0.58 0.09
93 INT51223 Regulation of Transcription of CSF3 1 0.39 0.53 0.06
94 INT253554 Regulation of Negative_regulation of Sp3 1 0.30 0 0.05
95 INT51222 Transcription of CSF3 1 0.59 0.52 0.05
96 INT187718 Negative_regulation of Positive_regulation of CYP19A1 1 0.33 0.61 0.05
97 INT303931 Protein_catabolism of Csf3 1 0.37 1.17 0.04
98 INT303930 Negative_regulation of Protein_catabolism of Csf3 1 0.18 1.2 0.04
99 INT332453 Positive_regulation of Phosphorylation of Csf3 1 0.27 0.43 0.04
100 INT289614 Positive_regulation of CITED2 1 0.37 0.41 0.03
101 INT310472 Negative_regulation of Gene_expression of Sfpi1 1 0.41 0.23 0.03
102 INT187720 Negative_regulation of Negative_regulation of CYP19A1 5 0.34 0.99 0
103 INT248769 Negative_regulation of Binding of CSF3 1 0.28 1.56 0
104 INT284294 Transcription of Spi1 1 0.67 0.36 0
105 INT284295 Negative_regulation of Gene_expression of Spi1 1 0.41 0.36 0
106 INT328198 Regulation of Binding of Csf3 1 0.03 0 0
107 INT187725 Positive_regulation of Localization of CYP19A1 1 0.39 0.23 0
108 INT292209 Regulation of SP3 1 0.17 0.34 0
109 INT136451 Protein_catabolism of Sp3 1 0.66 0.15 0
110 INT136461 Positive_regulation of Protein_catabolism of Sp3 1 0.46 0.15 0
111 INT213932 Negative_regulation of Negative_regulation of Cyp19a1 1 0.31 0.7 0
112 INT194353 Negative_regulation of Binding of Cyp19a1 1 0.15 0 0
113 INT145141 Negative_regulation of Transcription of CYP19A1 1 0.59 0.3 0
114 INT328199 Negative_regulation of Positive_regulation of CSF3 1 0.04 0 0
115 INT211062 Positive_regulation of Localization of CSF3 1 0.06 1.59 0
116 INT313601 Regulation of CITED2 1 0.00 0.8 0
117 INT106452 Negative_regulation of Positive_regulation of Spi1 1 0.30 0 0
118 INT187719 Negative_regulation of Localization of CYP19A1 1 0.33 0.78 0
119 INT253555 Regulation of Binding of Sp3 1 0.30 0.06 0
120 INT222306 Negative_regulation of Binding of CYP19A1 1 0.20 1.04 0
121 INT250466 Regulation of Gene_expression of Sfpi1 1 0.39 0.98 0
122 INT248767 Positive_regulation of Binding of CSF3 1 0.33 3.11 0
123 INT293482 Protein_catabolism of Sfpi1 1 0.09 0.52 0
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