GO:0030856

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Name regulation of epithelial cell differentiation
Categary Process
Go Slim No
Go Link GO:0030856
Unique Molecular Interactions 81
Total Molecular Interactions 90
Total Single Events 1000
Pain Genes Associated 14

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for regulation of epithelial cell differentiation. They are ordered first by their pain relevance and then by number of times they were reported for regulation of epithelial cell differentiation. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT42728 Binding of PRLR and Cpe 1 0.00 0 2.91
2 INT167944 Binding of Oprm1 and Stat5a 1 0.00 0 0.85
3 INT126614 Ppyr1 Negative_regulation of Phosphorylation of Stat5a 1 0.27 0.1 0.64
4 INT126615 Binding of Oprd1 and Stat5a 1 0.28 0.07 0.61
5 INT184130 Epo Positive_regulation of Stat5a 1 0.31 0.26 0.52
6 INT184096 Il7 Positive_regulation of Stat5a 1 0.07 0.26 0.51
7 INT184132 Il2 Positive_regulation of Stat5a 1 0.09 0.26 0.51
8 INT114297 Apc Negative_regulation of Gene_expression of Fcer2a 1 0.03 0.96 0.48
9 INT151890 Binding of PRLR and Adarb1 1 0.00 0 0.45
10 INT167946 Binding of SRC and Stat5b 1 0.28 0 0.38
11 INT300609 Binding of Ctnnb1 and Wnt2 1 0.02 0.25 0.37
12 INT124378 Prodh2 Positive_regulation of Ctnnb1 1 0.00 0.59 0.35
13 INT206208 MRO Negative_regulation of CD24 1 0.02 1.87 0.32
14 INT242164 Wnt2 Positive_regulation of Localization of Apc 1 0.13 1.53 0.32
15 INT62616 Regulation of Binding of PRLR and ST14 1 0.00 0 0.31
16 INT62615 Binding of PRLR and ST14 1 0.00 0 0.31
17 INT350813 Binding of Apc and Crp 1 0.18 1.12 0.27
18 INT25907 Binding of PRLR and Cish 1 0.00 0 0.23
19 INT151884 Binding of PRLR and YY1 1 0.01 0 0.23
20 INT316370 Ang Positive_regulation of Xdh 1 0.07 0.62 0.2
21 INT68510 Binding of ATM and PRLR 1 0.01 0 0.19
22 INT206212 UTS2R Positive_regulation of CD24 1 0.09 0.71 0.15
23 INT206209 MRO Negative_regulation of Transcription of CD24 1 0.02 0.76 0.14
24 INT184129 Socs2 Negative_regulation of Stat5a 1 0.22 0.05 0.13
25 INT242163 Wnt2 Positive_regulation of Regulation of Apc 1 0.13 0.71 0.13
26 INT251115 Positive_regulation of Binding of AR and Ctnnb1 1 0.01 1.02 0.13
27 INT316190 Apc Negative_regulation of Positive_regulation of Mapk1 1 0.33 0.66 0.12
28 INT251114 Binding of AR and Ctnnb1 1 0.01 1 0.12
29 INT184089 Gh Positive_regulation of Stat5b 1 0.13 1.3 0.1
30 INT270203 Binding of CD28 and Apc 1 0.04 0.58 0.08
31 INT290906 Shh Positive_regulation of Egfr 1 0.23 0 0.08
32 INT270197 Binding of Apc and Cd86 1 0.02 0.58 0.08
33 INT270198 Binding of Apc and Cd80 1 0.02 0.58 0.08
34 INT298349 HES3 Positive_regulation of Shh 1 0.12 0.14 0.07
35 INT290905 Gene_expression of Shh Positive_regulation of Gene_expression of Angpt1 1 0.14 0 0.06
36 INT267998 Binding of XDH and Nos1 1 0.02 0.46 0.06
37 INT176095 Binding of Apc and EC 1 0.04 0.51 0.05
38 INT120574 Binding of Apc and Egfr 1 0.27 1.02 0.05
39 INT206207 Binding of SLEB1 and CD24 1 0.03 0.87 0.03
40 INT206211 MRO Regulation of Negative_regulation of CD24 1 0.01 0.1 0.03
41 INT353192 Stat5a Positive_regulation of Plxna3 1 0.01 0 0
42 INT290910 Pkm2 Negative_regulation of Shh 1 0.07 0.06 0
43 INT213034 Hdl1 Positive_regulation of Apc 1 0.08 1.21 0
44 INT240867 Binding of Ros1 and Xdh 1 0.02 0.07 0
45 INT205963 GLI1 Positive_regulation of Negative_regulation of SHH 1 0.22 0.58 0
46 INT355603 Binding of CTNNA1 and Ctnnb1 1 0.00 1.07 0
47 INT269944 Gata6 Regulation of Gene_expression of Foxj1 1 0.19 0 0
48 INT220818 Binding of Ctnnb1 and Myc 1 0.06 0.13 0
49 INT341502 Negative_regulation of Binding of Apc and Pdcd1 1 0.00 0.53 0
50 INT290908 Regulation of Shh Positive_regulation of Ntn1 1 0.12 0 0
51 INT286566 Binding of Ctnnb1 and Cdh6 1 0.00 1 0
52 INT290911 Gene_expression of Shh Positive_regulation of Pkm2 1 0.07 0 0
53 INT286562 Gene_expression of Pkd1 Positive_regulation of Ctnnb1 1 0.02 0.52 0
54 INT290904 Shh Positive_regulation of Prkcg 1 0.26 0.06 0
55 INT290900 Prkcg Regulation of Shh 1 0.23 0 0
56 INT136693 Gtf3a Positive_regulation of Ctnnb1 1 0.05 0 0
57 INT191096 Negative_regulation of Binding of Apc and Esr1 1 0.05 1.07 0
58 INT205960 Binding of PTCH1 and SHH 1 0.21 0.71 0
59 INT286112 Binding of Apc and Afap1 1 0.05 0.71 0
60 INT290944 Shh Positive_regulation of VEGFA 1 0.04 0.05 0
61 INT269933 Foxa2 Regulation of Gene_expression of Foxj1 1 0.27 0 0
62 INT213007 Hdl1 Regulation of Regulation of Apc 1 0.08 1.24 0
63 INT205959 Binding of SHH and SMOX 1 0.12 0.72 0
64 INT220821 Binding of MAX and Ctnnb1 1 0.09 0.13 0
65 INT191095 Positive_regulation of Binding of Apc and Esr1 1 0.06 1.08 0
66 INT290898 Shh Positive_regulation of Nos2 1 0.46 0.05 0
67 INT286561 Binding of Ctnnb1 and Cdh2 1 0.00 1.06 0
68 INT286567 Prkd1 Regulation of Ctnnb1 1 0.01 0.39 0
69 INT353190 Stat5a Positive_regulation of Cyp2c11 1 0.31 0 0
70 INT213009 Hdl1 Positive_regulation of Positive_regulation of Apc 1 0.09 1.14 0
71 INT191801 Binding of SELP and CD24 1 0.12 0.67 0
72 INT191098 Binding of Apc and Esr1 1 0.04 1.06 0
73 INT290907 Shh Positive_regulation of Ntn1 1 0.32 0.05 0
74 INT205977 Binding of SHH and Ptch1 1 0.31 0.71 0
75 INT213025 Vtn Positive_regulation of Apc 1 0.01 1.19 0
76 INT269939 Foxa1 Regulation of Gene_expression of Foxj1 1 0.26 0 0
77 INT213054 Hdl1 Regulation of Apc 1 0.05 1.24 0
78 INT286572 Binding of Ctnnb1 and Pkd1 1 0.02 0.96 0
79 INT236721 Binding of Apc and Ctnnd2 1 0.25 1.03 0
80 INT341501 Binding of Apc and Pdcd1 1 0.00 0.52 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for regulation of epithelial cell differentiation. They are ordered first by their pain relevance and then by number of times they were reported in regulation of epithelial cell differentiation. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT12367 Binding of PRLR 17 0.03 2.05 9.69
2 INT16720 Negative_regulation of Xdh 35 0.59 14 6.67
3 INT3819 Positive_regulation of Apc 36 0.69 27.03 6.02
4 INT87022 Gene_expression of Apc 68 0.67 46.98 5.22
5 INT13313 Regulation of PRLR 7 0.07 1.65 4.77
6 INT126608 Binding of Stat5a 7 0.48 0.46 4.38
7 INT3817 Negative_regulation of Apc 29 0.58 22.12 3.91
8 INT22223 Positive_regulation of Xdh 18 0.67 5.87 3.84
9 INT18825 Gene_expression of PRLR 8 0.40 2 3.47
10 INT191807 Gene_expression of CD24 75 0.78 53.92 3.34
11 INT20082 Positive_regulation of PRLR 6 0.29 4.27 3.03
12 INT101567 Gene_expression of Ctnnb1 7 0.64 10.11 2.89
13 INT14902 Negative_regulation of XDH 38 0.55 24.19 2.86
14 INT22194 Gene_expression of Xdh 20 0.75 10.03 2.83
15 INT25646 Negative_regulation of PRLR 5 0.08 0.08 2.62
16 INT126610 Phosphorylation of Stat5a 5 0.82 0.8 2.52
17 INT34266 Negative_regulation of Binding of PRLR 3 0.01 0 2.35
18 INT81641 Gene_expression of Ctnnb1 23 0.72 14.93 1.97
19 INT144973 Gene_expression of Shh 9 0.77 4.32 1.96
20 INT126609 Positive_regulation of Phosphorylation of Stat5a 1 0.69 0.26 1.79
21 INT19626 Regulation of Xdh 4 0.22 2.69 1.7
22 INT3818 Regulation of Apc 13 0.39 12.52 1.68
23 INT123990 Positive_regulation of Ctnnb1 8 0.43 2.85 1.63
24 INT99391 Localization of Ctnnb1 7 0.80 5.84 1.61
25 INT3892 Positive_regulation of XDH 8 0.67 8.57 1.5
26 INT206244 Binding of CD24 7 0.48 5.71 1.43
27 INT220177 Binding of Apc 21 0.37 15.34 1.37
28 INT110569 Gene_expression of XDH 31 0.75 18.35 1.34
29 INT110434 Positive_regulation of Gene_expression of Apc 20 0.50 11.37 1.3
30 INT126605 Negative_regulation of Binding of Stat5a 1 0.58 0.15 1.27
31 INT191804 Transcription of CD24 10 0.72 12.43 1.25
32 INT99389 Negative_regulation of Ctnnb1 8 0.45 3.97 1.21
33 INT253191 Positive_regulation of Gene_expression of Shh 2 0.66 2.57 1.14
34 INT20080 Localization of PRLR 2 0.03 0.42 1.12
35 INT101570 Positive_regulation of Gene_expression of Ctnnb1 1 0.58 5.7 1.07
36 INT165530 Positive_regulation of Shh 4 0.69 1.21 1.05
37 INT22224 Positive_regulation of Positive_regulation of Xdh 3 0.42 0.87 0.92
38 INT242134 Localization of Apc 8 0.74 4.83 0.88
39 INT101566 Negative_regulation of Gene_expression of Ctnnb1 1 0.35 2.28 0.88
40 INT184015 Positive_regulation of Stat5a 9 0.46 3.32 0.86
41 INT167938 Positive_regulation of Phosphorylation of Stat5b 1 0.33 0 0.85
42 INT167942 Binding of Stat5b 1 0.26 0 0.82
43 INT191806 Positive_regulation of Gene_expression of CD24 13 0.70 9.94 0.79
44 INT191811 Regulation of CD24 7 0.45 6 0.72
45 INT99390 Regulation of Ctnnb1 4 0.62 3.12 0.64
46 INT126606 Negative_regulation of Stat5a 1 0.43 0.08 0.64
47 INT159942 Positive_regulation of Stat5a 3 0.41 0.95 0.61
48 INT104632 Negative_regulation of Positive_regulation of Xdh 2 0.14 0.9 0.61
49 INT126612 Negative_regulation of Phosphorylation of Stat5a 1 0.42 0.1 0.61
50 INT179373 Localization of XDH 3 0.20 1.97 0.54
51 INT76960 Negative_regulation of Ctnnb1 5 0.57 3.46 0.53
52 INT227331 Binding of Xdh 5 0.29 1.83 0.49
53 INT95375 Regulation of Transcription of PRLR 1 0.00 0 0.49
54 INT95377 Regulation of Gene_expression of PRLR 1 0.00 0 0.49
55 INT95376 Transcription of PRLR 1 0.00 0 0.49
56 INT81645 Positive_regulation of Gene_expression of Ctnnb1 6 0.63 3.78 0.47
57 INT151720 Negative_regulation of Positive_regulation of Apc 3 0.37 2.15 0.46
58 INT191803 Positive_regulation of CD24 6 0.70 5.49 0.43
59 INT152151 Regulation of Gene_expression of Apc 4 0.44 3.87 0.42
60 INT167941 Phosphorylation of Stat5b 1 0.58 0 0.42
61 INT76958 Positive_regulation of Ctnnb1 14 0.64 5.48 0.41
62 INT95872 Localization of Ctnnb1 7 0.74 2.75 0.4
63 INT111388 Negative_regulation of Gene_expression of Xdh 1 0.13 0.51 0.38
64 INT81644 Regulation of Ctnnb1 5 0.41 3.38 0.37
65 INT81643 Regulation of Gene_expression of Ctnnb1 3 0.57 1.5 0.37
66 INT220170 Regulation of Positive_regulation of Apc 1 0.10 0.46 0.35
67 INT191805 Negative_regulation of CD24 4 0.58 0.61 0.32
68 INT225667 Transcription of Apc 3 0.52 3.73 0.32
69 INT261239 Binding of XDH 10 0.34 3.16 0.31
70 INT191809 Regulation of Gene_expression of CD24 5 0.45 3.04 0.31
71 INT108324 Negative_regulation of Gene_expression of Ctnnb1 1 0.06 1.43 0.31
72 INT20081 Positive_regulation of Localization of PRLR 1 0.03 0.07 0.27
73 INT151719 Negative_regulation of Positive_regulation of Ctnnb1 1 0.23 1.9 0.24
74 INT332501 Negative_regulation of Negative_regulation of CD24 1 0.24 0.23 0.22
75 INT225666 Regulation of Transcription of Apc 1 0.29 0.33 0.22
76 INT183062 Gene_expression of SHH 12 0.65 5.28 0.21
77 INT134477 Negative_regulation of SHH 2 0.37 1.13 0.2
78 INT62617 Positive_regulation of Positive_regulation of PRLR 1 0.01 0 0.19
79 INT167940 Regulation of Stat5b 1 0.43 0 0.19
80 INT206238 Negative_regulation of Transcription of CD24 1 0.43 1.1 0.18
81 INT99392 Negative_regulation of Localization of Ctnnb1 2 0.59 1.43 0.17
82 INT151721 Negative_regulation of Localization of Ctnnb1 1 0.23 0.96 0.17
83 INT184024 Binding of Stat5a 1 0.25 0.11 0.17
84 INT206239 Regulation of Transcription of CD24 1 0.45 0.96 0.17
85 INT325506 Positive_regulation of Localization of Ctnnb1 1 0.05 0.28 0.17
86 INT228603 Positive_regulation of Positive_regulation of Apc 1 0.24 0.24 0.17
87 INT184055 Positive_regulation of Binding of Stat5a 1 0.33 0.12 0.17
88 INT253177 Negative_regulation of Gene_expression of Shh 2 0.55 0.63 0.16
89 INT113024 Regulation of Gene_expression of Xdh 1 0.03 0.1 0.16
90 INT206805 Negative_regulation of Gene_expression of CD24 1 0.43 1.48 0.16
91 INT350667 Positive_regulation of Transcription of Stat5a 1 0.29 0.47 0.16
92 INT255793 Positive_regulation of Gene_expression of Xdh 1 0.12 0.27 0.16
93 INT350637 Transcription of Stat5a 1 0.40 0.46 0.16
94 INT191810 Positive_regulation of Transcription of CD24 3 0.60 2.88 0.15
95 INT267995 Negative_regulation of Negative_regulation of XDH 2 0.30 0.77 0.15
96 INT223026 Regulation of XDH 2 0.32 2.38 0.15
97 INT324856 Localization of Xdh 1 0.04 0.61 0.15
98 INT253190 Localization of Shh 2 0.77 1.06 0.13
99 INT130374 Transcription of Ctnnb1 1 0.19 0 0.13
100 INT253183 Negative_regulation of Shh 8 0.55 2.13 0.12
101 INT242140 Regulation of Localization of Apc 1 0.12 0.12 0.11
102 INT220368 Negative_regulation of Positive_regulation of Stat5a 1 0.34 0.46 0.11
103 INT206251 Protein_catabolism of CD24 1 0.66 0.62 0.11
104 INT242819 Negative_regulation of Gene_expression of Apc 4 0.37 5.6 0.1
105 INT263205 Negative_regulation of Gene_expression of XDH 2 0.41 0.63 0.1
106 INT320095 Negative_regulation of Binding of XDH 1 0.16 0.46 0.1
107 INT110568 Positive_regulation of Gene_expression of XDH 7 0.49 5.14 0.09
108 INT350646 Negative_regulation of Positive_regulation of Stat5a 1 0.25 0.23 0.08
109 INT313905 Localization of Stat5a 1 0.21 0.33 0.08
110 INT205973 Binding of SHH 3 0.35 1.03 0.07
111 INT121075 Positive_regulation of Negative_regulation of Xdh 1 0.11 0 0.07
112 INT256862 Regulation of Shh 1 0.25 0 0.07
113 INT267994 Positive_regulation of Negative_regulation of XDH 1 0.33 0.37 0.07
114 INT235057 Positive_regulation of Negative_regulation of Apc 2 0.30 0.66 0.05
115 INT181793 Positive_regulation of SHH 3 0.67 2.59 0.04
116 INT184061 Negative_regulation of Stat5a 2 0.29 1.85 0.04
117 INT269499 Regulation of Negative_regulation of Xdh 1 0.32 0.38 0.04
118 INT242139 Protein_catabolism of Apc 1 0.17 0.27 0.03
119 INT253187 Negative_regulation of Transcription of Shh 1 0.41 0.55 0.03
120 INT253181 Transcription of Shh 1 0.68 0.54 0.03
121 INT267997 Positive_regulation of Positive_regulation of XDH 1 0.35 0.83 0.03
122 INT173796 Gene_expression of Stat5a 5 0.56 1.41 0
123 INT110570 Regulation of Gene_expression of XDH 3 0.32 1.36 0
124 INT200803 Phosphorylation of Stat5a 2 0.59 1.23 0
125 INT206806 Phosphorylation of CD24 2 0.63 1.35 0
126 INT76959 Binding of Ctnnb1 2 0.34 0.69 0
127 INT230651 Phosphorylation of Ctnnb1 1 0.10 0 0
128 INT230674 Positive_regulation of Phosphorylation of Ctnnb1 1 0.06 0 0
129 INT326137 Protein_catabolism of Ctnnb1 1 0.02 1.08 0
130 INT200800 Positive_regulation of Phosphorylation of Stat5a 1 0.36 0.24 0
131 INT104591 Negative_regulation of Negative_regulation of Apc 1 0.04 0.16 0
132 INT355576 Negative_regulation of Negative_regulation of Ctnnb1 1 0.02 1.14 0
133 INT269905 Positive_regulation of Foxj1 1 0.32 0.08 0
134 INT110572 Transcription of XDH 1 0.52 0.15 0
135 INT220769 Positive_regulation of Positive_regulation of Ctnnb1 1 0.10 0 0
136 INT191087 Regulation of Regulation of Apc 1 0.06 1.02 0
137 INT290918 Negative_regulation of Positive_regulation of Shh 1 0.41 0.25 0
138 INT110571 Positive_regulation of Transcription of XDH 1 0.45 0 0
139 INT191808 Localization of CD24 1 0.74 1.6 0
140 INT286093 Regulation of Binding of Apc 1 0.39 1.08 0
141 INT200799 Positive_regulation of Gene_expression of Stat5a 1 0.36 0.37 0
142 INT302001 Positive_regulation of Binding of CD24 1 0.21 0.42 0
143 INT230972 Positive_regulation of Gene_expression of SHH 1 0.18 0.07 0
144 INT269900 Gene_expression of Foxj1 1 0.49 0.25 0
145 INT353174 Gene_expression of Stat5b 1 0.48 0 0
146 INT290929 Binding of Shh 1 0.31 0.1 0
147 INT200790 Positive_regulation of Positive_regulation of Stat5a 1 0.36 0.24 0
148 INT290927 Regulation of Positive_regulation of Shh 1 0.23 0 0
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