GO:0030858

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Name positive regulation of epithelial cell differentiation
Categary Process
Go Slim No
Go Link GO:0030858
Unique Molecular Interactions 98
Total Molecular Interactions 115
Total Single Events 1027
Pain Genes Associated 11

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for positive regulation of epithelial cell differentiation. They are ordered first by their pain relevance and then by number of times they were reported for positive regulation of epithelial cell differentiation. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT84886 APC Regulation of PPARD 1 0.51 1.57 1.26
2 INT195778 Binding of APC and PROCR 7 0.19 3.78 0.73
3 INT182150 Binding of APC and DCPS 1 0.02 1.14 0.48
4 INT114297 Apc Negative_regulation of Gene_expression of Fcer2a 1 0.03 0.96 0.48
5 INT300609 Binding of Ctnnb1 and Wnt2 1 0.02 0.25 0.37
6 INT84887 APC Negative_regulation of Gene_expression of PPARD 1 0.36 0.55 0.37
7 INT124378 Prodh2 Positive_regulation of Ctnnb1 1 0.00 0.59 0.35
8 INT195665 APC Negative_regulation of F8 1 0.04 1.53 0.32
9 INT242164 Wnt2 Positive_regulation of Localization of Apc 1 0.13 1.53 0.32
10 INT195664 APC Negative_regulation of F5 1 0.08 1.51 0.31
11 INT63122 Binding of APC and Man2a2 1 0.01 0.15 0.3
12 INT289954 Binding of APC and CD28 1 0.03 0.38 0.28
13 INT350813 Binding of Apc and Crp 1 0.18 1.12 0.27
14 INT235976 Binding of APC and Trav6-3 2 0.01 2.62 0.24
15 INT235974 Negative_regulation of Binding of APC and Trav6-3 1 0.00 1.15 0.24
16 INT235972 Negative_regulation of Binding of APC and Bcr 1 0.01 1.15 0.24
17 INT235973 Binding of APC and Bcr 1 0.01 1.14 0.24
18 INT109408 Negative_regulation of APC Negative_regulation of Positive_regulation of RASGRP1 1 0.06 0.73 0.23
19 INT250783 APC Negative_regulation of SERPINE1 1 0.06 0.86 0.23
20 INT250782 APC Negative_regulation of F2 1 0.00 0.86 0.23
21 INT316111 APC Negative_regulation of SAE1 1 0.04 1.21 0.22
22 INT195663 APC Negative_regulation of Gene_expression of IL6 1 0.16 1.18 0.22
23 INT316110 Binding of APC and SAE1 1 0.03 1.16 0.2
24 INT334106 APC Negative_regulation of NFKB1 1 0.25 1.37 0.17
25 INT334108 APC Negative_regulation of TNF 1 0.13 1.36 0.17
26 INT289956 Binding of APC and ICAM1 1 0.04 0.5 0.13
27 INT242163 Wnt2 Positive_regulation of Regulation of Apc 1 0.13 0.71 0.13
28 INT223535 Binding of HAND1 and Pax6 1 0.33 0.92 0.13
29 INT251115 Positive_regulation of Binding of AR and Ctnnb1 1 0.01 1.02 0.13
30 INT184603 APC Negative_regulation of Gene_expression of TNF 1 0.09 0.97 0.13
31 INT223526 Binding of Pax6 and Tcf3 1 0.33 0.92 0.13
32 INT316190 Apc Negative_regulation of Positive_regulation of Mapk1 1 0.33 0.66 0.12
33 INT184608 APC Regulation of Gene_expression of Nppa 1 0.06 1.11 0.12
34 INT251114 Binding of AR and Ctnnb1 1 0.01 1 0.12
35 INT299754 Binding of APC and CTLA4 2 0.08 0.97 0.11
36 INT262255 Binding of APC and F2R 1 0.05 3 0.1
37 INT270203 Binding of CD28 and Apc 1 0.04 0.58 0.08
38 INT270197 Binding of Apc and Cd86 1 0.02 0.58 0.08
39 INT245118 RBM45 Negative_regulation of CDKN2B 1 0.01 1.41 0.08
40 INT270198 Binding of Apc and Cd80 1 0.02 0.58 0.08
41 INT245119 Negative_regulation of RBM45 Negative_regulation of CDKN2B 1 0.01 1.43 0.08
42 INT201173 Sox2 Positive_regulation of Localization of Ryr2 1 0.40 0.9 0.07
43 INT201172 Sox2 Positive_regulation of Localization of Ca2 1 0.47 0.9 0.07
44 INT176095 Binding of Apc and EC 1 0.04 0.51 0.05
45 INT213562 Ctnnd2 Regulation of Gene_expression of Sox2 1 0.35 0.07 0.05
46 INT120574 Binding of Apc and Egfr 1 0.27 1.02 0.05
47 INT334107 Binding of APC and APCS 1 0.16 1.52 0.04
48 INT322891 Sox9 Regulation of Transcription of Col2a1 1 0.10 0.12 0.04
49 INT184208 IL1B Negative_regulation of SOX9 1 0.32 0 0.03
50 INT210260 Sox9 Negative_regulation of Cdx2 1 0.20 0 0.03
51 INT213034 Hdl1 Positive_regulation of Apc 1 0.08 1.21 0
52 INT215686 Cdkn2b Negative_regulation of Cdkn1c 1 0.01 0 0
53 INT355603 Binding of CTNNA1 and Ctnnb1 1 0.00 1.07 0
54 INT220818 Binding of Ctnnb1 and Myc 1 0.06 0.13 0
55 INT341502 Negative_regulation of Binding of Apc and Pdcd1 1 0.00 0.53 0
56 INT320029 Gene_expression of SOX9 Positive_regulation of Gene_expression of COL7A1 1 0.03 0 0
57 INT245726 SOX9 Regulation of SGCG 1 0.00 0.29 0
58 INT286566 Binding of Ctnnb1 and Cdh6 1 0.00 1 0
59 INT286562 Gene_expression of Pkd1 Positive_regulation of Ctnnb1 1 0.02 0.52 0
60 INT333879 Shc1 Positive_regulation of SOX9 1 0.01 0 0
61 INT225570 Ncoa6 Regulation of Sox9 1 0.16 0.72 0
62 INT136693 Gtf3a Positive_regulation of Ctnnb1 1 0.05 0 0
63 INT191096 Negative_regulation of Binding of Apc and Esr1 1 0.05 1.07 0
64 INT301675 Binding of APC and HLA-E 1 0.01 1.48 0
65 INT215700 Binding of Cdkn2b and Cdk6 1 0.02 0 0
66 INT286112 Binding of Apc and Afap1 1 0.05 0.71 0
67 INT265233 Binding of APC and FKBP1A 1 0.08 0.41 0
68 INT213007 Hdl1 Regulation of Regulation of Apc 1 0.08 1.24 0
69 INT185271 Pax6 Regulation of Psmd1 1 0.02 0 0
70 INT301674 Binding of APC and CD80 1 0.01 0.53 0
71 INT220821 Binding of MAX and Ctnnb1 1 0.09 0.13 0
72 INT195661 Binding of APC and PROC 1 0.23 0.89 0
73 INT253019 APC Positive_regulation of Protein_catabolism of Pttg1 1 0.06 0 0
74 INT253012 APC Positive_regulation of Binding of Pttg1 1 0.06 0 0
75 INT268342 Binding of APC and ANKS1B 1 0.01 0.92 0
76 INT191095 Positive_regulation of Binding of Apc and Esr1 1 0.06 1.08 0
77 INT301677 Binding of APC and CD8A 1 0.03 1.48 0
78 INT286561 Binding of Ctnnb1 and Cdh2 1 0.00 1.06 0
79 INT265232 Regulation of Binding of APC and FKBP1A 1 0.08 0.41 0
80 INT268395 Binding of APC and Kras 1 0.04 1.21 0
81 INT286567 Prkd1 Regulation of Ctnnb1 1 0.01 0.39 0
82 INT213009 Hdl1 Positive_regulation of Positive_regulation of Apc 1 0.09 1.14 0
83 INT284915 Binding of CDKN2B and HIST2H3C 1 0.05 0.43 0
84 INT80660 INS Positive_regulation of APC 1 0.32 0.65 0
85 INT215688 Cdkn2b Negative_regulation of Kras 1 0.00 0 0
86 INT283362 AXIN2 Negative_regulation of APC 1 0.10 1.67 0
87 INT191098 Binding of Apc and Esr1 1 0.04 1.06 0
88 INT215694 Cdkn2b Negative_regulation of Cdkn1b 1 0.01 0 0
89 INT195659 APC Positive_regulation of Gene_expression of PROC 1 0.26 0.31 0
90 INT213025 Vtn Positive_regulation of Apc 1 0.01 1.19 0
91 INT213054 Hdl1 Regulation of Apc 1 0.05 1.24 0
92 INT286572 Binding of Ctnnb1 and Pkd1 1 0.02 0.96 0
93 INT80659 Positive_regulation of INS Positive_regulation of APC 1 0.32 0.65 0
94 INT236721 Binding of Apc and Ctnnd2 1 0.25 1.03 0
95 INT245735 SOX9 Regulation of COL5A2 1 0.07 0.29 0
96 INT283716 Neurod1 Positive_regulation of Pax6 1 0.23 0.46 0
97 INT252909 FZR1 Positive_regulation of APC 1 0.06 0.08 0
98 INT341501 Binding of Apc and Pdcd1 1 0.00 0.52 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for positive regulation of epithelial cell differentiation. They are ordered first by their pain relevance and then by number of times they were reported in positive regulation of epithelial cell differentiation. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT57057 Gene_expression of APC 131 0.78 122.24 8.7
2 INT16631 Negative_regulation of APC 46 0.57 30.53 7.11
3 INT3819 Positive_regulation of Apc 36 0.69 27.03 6.02
4 INT87022 Gene_expression of Apc 68 0.67 46.98 5.22
5 INT57064 Positive_regulation of APC 72 0.66 48.5 5.08
6 INT3817 Negative_regulation of Apc 29 0.58 22.12 3.91
7 INT63121 Binding of APC 29 0.41 23.02 3.8
8 INT101567 Gene_expression of Ctnnb1 7 0.64 10.11 2.89
9 INT81641 Gene_expression of Ctnnb1 23 0.72 14.93 1.97
10 INT3818 Regulation of Apc 13 0.39 12.52 1.68
11 INT123990 Positive_regulation of Ctnnb1 8 0.43 2.85 1.63
12 INT99391 Localization of Ctnnb1 7 0.80 5.84 1.61
13 INT220177 Binding of Apc 21 0.37 15.34 1.37
14 INT110434 Positive_regulation of Gene_expression of Apc 20 0.50 11.37 1.3
15 INT99389 Negative_regulation of Ctnnb1 8 0.45 3.97 1.21
16 INT134663 Gene_expression of SOX9 40 0.75 9.07 1.2
17 INT102073 Regulation of Gene_expression of APC 5 0.45 6.09 1.15
18 INT102074 Positive_regulation of Gene_expression of APC 20 0.50 13.66 1.1
19 INT101570 Positive_regulation of Gene_expression of Ctnnb1 1 0.58 5.7 1.07
20 INT166715 Gene_expression of Sox9 16 0.65 6.39 0.92
21 INT242134 Localization of Apc 8 0.74 4.83 0.88
22 INT101566 Negative_regulation of Gene_expression of Ctnnb1 1 0.35 2.28 0.88
23 INT145306 Gene_expression of Sox9 5 0.54 2.47 0.8
24 INT57062 Regulation of APC 24 0.58 14.3 0.7
25 INT80674 Negative_regulation of Gene_expression of APC 16 0.59 18.14 0.69
26 INT99390 Regulation of Ctnnb1 4 0.62 3.12 0.64
27 INT185244 Gene_expression of Sox2 27 0.65 4.71 0.61
28 INT184222 Negative_regulation of SOX9 7 0.41 2.68 0.58
29 INT157103 Transcription of SOX9 6 0.59 1.2 0.58
30 INT72869 Regulation of Negative_regulation of APC 2 0.36 1.7 0.54
31 INT76960 Negative_regulation of Ctnnb1 5 0.57 3.46 0.53
32 INT157104 Positive_regulation of SOX9 6 0.66 1.66 0.52
33 INT157105 Positive_regulation of Transcription of SOX9 4 0.58 0.88 0.51
34 INT100191 Gene_expression of Cdkn2b 1 0.65 0.06 0.51
35 INT81645 Positive_regulation of Gene_expression of Ctnnb1 6 0.63 3.78 0.47
36 INT151720 Negative_regulation of Positive_regulation of Apc 3 0.37 2.15 0.46
37 INT145304 Regulation of Gene_expression of Sox9 1 0.43 1.04 0.46
38 INT152151 Regulation of Gene_expression of Apc 4 0.44 3.87 0.42
39 INT185255 Positive_regulation of Sox2 3 0.26 1.22 0.42
40 INT76958 Positive_regulation of Ctnnb1 14 0.64 5.48 0.41
41 INT95872 Localization of Ctnnb1 7 0.74 2.75 0.4
42 INT81644 Regulation of Ctnnb1 5 0.41 3.38 0.37
43 INT81643 Regulation of Gene_expression of Ctnnb1 3 0.57 1.5 0.37
44 INT220170 Regulation of Positive_regulation of Apc 1 0.10 0.46 0.35
45 INT118243 Transcription of APC 4 0.45 3.33 0.33
46 INT184605 Positive_regulation of Transcription of APC 2 0.19 2.39 0.33
47 INT225667 Transcription of Apc 3 0.52 3.73 0.32
48 INT108324 Negative_regulation of Gene_expression of Ctnnb1 1 0.06 1.43 0.31
49 INT195672 Localization of APC 7 0.74 3.76 0.3
50 INT201143 Regulation of Sox2 6 0.44 2.71 0.26
51 INT123541 Regulation of Gene_expression of Cdkn2b 1 0.26 0.06 0.26
52 INT151719 Negative_regulation of Positive_regulation of Ctnnb1 1 0.23 1.9 0.24
53 INT145303 Regulation of Sox9 2 0.28 0.71 0.22
54 INT225666 Regulation of Transcription of Apc 1 0.29 0.33 0.22
55 INT245763 Regulation of SOX9 4 0.43 1.68 0.21
56 INT134662 Positive_regulation of Gene_expression of SOX9 9 0.48 1.69 0.19
57 INT173166 Negative_regulation of Binding of APC 3 0.40 3.01 0.19
58 INT57065 Negative_regulation of Positive_regulation of APC 3 0.22 2.43 0.17
59 INT99392 Negative_regulation of Localization of Ctnnb1 2 0.59 1.43 0.17
60 INT151721 Negative_regulation of Localization of Ctnnb1 1 0.23 0.96 0.17
61 INT325506 Positive_regulation of Localization of Ctnnb1 1 0.05 0.28 0.17
62 INT228603 Positive_regulation of Positive_regulation of Apc 1 0.24 0.24 0.17
63 INT185254 Gene_expression of Pax6 14 0.72 1.77 0.16
64 INT250790 Negative_regulation of Localization of APC 2 0.13 2.3 0.13
65 INT250792 Positive_regulation of Localization of APC 1 0.15 0.48 0.13
66 INT130374 Transcription of Ctnnb1 1 0.19 0 0.13
67 INT211949 Negative_regulation of Sox9 1 0.31 0.83 0.12
68 INT201144 Regulation of Gene_expression of Sox2 3 0.44 0.82 0.11
69 INT242140 Regulation of Localization of Apc 1 0.12 0.12 0.11
70 INT242819 Negative_regulation of Gene_expression of Apc 4 0.37 5.6 0.1
71 INT201140 Transcription of Sox2 4 0.67 1.31 0.1
72 INT184220 Negative_regulation of Gene_expression of SOX9 4 0.36 0.58 0.09
73 INT268372 Phosphorylation of APC 3 0.81 3.39 0.09
74 INT211948 Regulation of Gene_expression of Sox9 2 0.33 0.94 0.08
75 INT245123 Gene_expression of CDKN2B 6 0.68 3.62 0.07
76 INT184989 Positive_regulation of CDKN2B 3 0.47 2.77 0.07
77 INT185030 Binding of CDKN2B 3 0.35 2.6 0.07
78 INT210242 Positive_regulation of Sox9 3 0.43 0.35 0.06
79 INT211939 Regulation of Sox9 1 0.33 0.35 0.06
80 INT195679 Positive_regulation of Positive_regulation of APC 6 0.50 4.43 0.05
81 INT235057 Positive_regulation of Negative_regulation of Apc 2 0.30 0.66 0.05
82 INT185260 Positive_regulation of Positive_regulation of Sox2 1 0.15 0 0.05
83 INT213537 Positive_regulation of Gene_expression of Sox2 3 0.48 1.34 0.04
84 INT213528 Negative_regulation of Gene_expression of Sox2 1 0.30 0.07 0.04
85 INT225365 Binding of Sox9 2 0.28 0.48 0.03
86 INT145302 Positive_regulation of Sox9 2 0.48 1.42 0.03
87 INT206481 Transcription of Pax6 2 0.41 0.19 0.03
88 INT242139 Protein_catabolism of Apc 1 0.17 0.27 0.03
89 INT336419 Negative_regulation of Gene_expression of Pax6 1 0.45 0.12 0.03
90 INT195681 Positive_regulation of Negative_regulation of APC 5 0.47 3.9 0
91 INT162339 Regulation of Gene_expression of SOX9 4 0.32 0.42 0
92 INT201142 Negative_regulation of Sox2 4 0.57 0.59 0
93 INT245757 Localization of SOX9 4 0.62 0.8 0
94 INT211945 Negative_regulation of Gene_expression of Sox9 3 0.44 0.63 0
95 INT201141 Binding of Sox2 3 0.36 0.53 0
96 INT284972 Negative_regulation of CDKN2B 3 0.44 1.13 0
97 INT76959 Binding of Ctnnb1 2 0.34 0.69 0
98 INT291889 Negative_regulation of Pax6 2 0.45 0.39 0
99 INT284937 Negative_regulation of Positive_regulation of CDKN2B 1 0.37 0.31 0
100 INT322883 Regulation of Transcription of Sox9 1 0.43 0.18 0
101 INT230651 Phosphorylation of Ctnnb1 1 0.10 0 0
102 INT230674 Positive_regulation of Phosphorylation of Ctnnb1 1 0.06 0 0
103 INT326137 Protein_catabolism of Ctnnb1 1 0.02 1.08 0
104 INT337657 Negative_regulation of Negative_regulation of APC 1 0.37 0.99 0
105 INT104591 Negative_regulation of Negative_regulation of Apc 1 0.04 0.16 0
106 INT355576 Negative_regulation of Negative_regulation of Ctnnb1 1 0.02 1.14 0
107 INT337673 Regulation of Positive_regulation of APC 1 0.38 1.44 0
108 INT324196 Positive_regulation of Gene_expression of Pax6 1 0.36 0 0
109 INT211943 Transcription of Sox9 1 0.50 0.3 0
110 INT323815 Negative_regulation of Transcription of SOX9 1 0.41 0.18 0
111 INT291888 Regulation of Gene_expression of Pax6 1 0.33 0 0
112 INT220769 Positive_regulation of Positive_regulation of Ctnnb1 1 0.10 0 0
113 INT191087 Regulation of Regulation of Apc 1 0.06 1.02 0
114 INT336416 Binding of Pax6 1 0.28 0 0
115 INT322886 Transcription of Sox9 1 0.50 0.25 0
116 INT201146 Negative_regulation of Binding of Sox2 1 0.41 0.28 0
117 INT284941 Transcription of CDKN2B 1 0.63 1.59 0
118 INT283365 Positive_regulation of Binding of APC 1 0.50 1.43 0
119 INT145307 Positive_regulation of Positive_regulation of Sox9 1 0.48 0.07 0
120 INT337667 Regulation of Transcription of APC 1 0.23 1 0
121 INT284970 Positive_regulation of Gene_expression of CDKN2B 1 0.61 0.55 0
122 INT286093 Regulation of Binding of Apc 1 0.39 1.08 0
123 INT245752 Positive_regulation of Binding of SOX9 1 0.41 0.48 0
124 INT147085 Binding of Cdkn2b 1 0.10 0.07 0
125 INT336420 Positive_regulation of Binding of Pax6 1 0.38 0 0
126 INT201139 Localization of Sox2 1 0.73 0.15 0
127 INT291885 Regulation of Pax6 1 0.15 0 0
128 INT284988 Positive_regulation of Transcription of CDKN2B 1 0.44 1.1 0
129 INT245765 Binding of SOX9 1 0.31 0.87 0
130 INT312245 Positive_regulation of Localization of SOX9 1 0.10 0 0
131 INT200852 Positive_regulation of Pax6 1 0.11 0 0
132 INT208927 Localization of Pax6 1 0.11 0 0
133 INT352010 Protein_catabolism of Sox9 1 0.22 0.07 0
134 INT308349 Positive_regulation of Gene_expression of Sox9 1 0.40 0.69 0
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