GO:0030866

From wiki-pain
Jump to: navigation, search
Name cortical actin cytoskeleton organization
Categary Process
Go Slim No
Go Link GO:0030866
Unique Molecular Interactions 101
Total Molecular Interactions 154
Total Single Events 1025
Pain Genes Associated 13

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for cortical actin cytoskeleton organization. They are ordered first by their pain relevance and then by number of times they were reported for cortical actin cytoskeleton organization. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT158711 Cdk5 Positive_regulation of Phosphorylation of Trh 1 0.02 0 1.46
2 INT124918 Binding of PLEK and Maob 1 0.10 1.05 0.98
3 INT129881 Binding of Calr and Cbll1 1 0.00 0.58 0.84
4 INT316673 Binding of CALR and LRP1 1 0.39 1.89 0.74
5 INT162164 ARF6 Regulation of Positive_regulation of PLD2 1 0.60 0 0.74
6 INT259556 PLEK Negative_regulation of Gene_expression of VEGFA 1 0.46 2.15 0.73
7 INT259557 PLEK Negative_regulation of Positive_regulation of VEGFA 1 0.46 2.15 0.73
8 INT162162 ARF6 Regulation of OPRM1 1 0.19 0 0.71
9 INT134476 Cdk5 Regulation of Map2k1 1 0.69 0.88 0.71
10 INT81968 Binding of PLEK and Adra2a 1 0.07 0.1 0.7
11 INT318981 Binding of CALR and GOPC 1 0.03 0.77 0.64
12 INT273235 Binding of Cdk5 and Cdk5r1 1 0.24 6.06 0.46
13 INT310600 Tbxa2r Positive_regulation of PLEK 1 0.53 0.45 0.38
14 INT139566 Binding of PLEK and Tbxa2r 1 0.01 1.14 0.38
15 INT316675 Binding of CALR and SFTPD 1 0.35 0.96 0.37
16 INT273234 Negative_regulation of Cdk5 Positive_regulation of Ptprs 1 0.14 1.26 0.34
17 INT39594 TPO Positive_regulation of CALR 1 0.30 0.91 0.32
18 INT296459 Binding of Dlg1 and Gria1 1 0.02 0.23 0.31
19 INT298995 Il18 Positive_regulation of Gene_expression of Cdk5 1 0.12 1.65 0.29
20 INT299008 Il18 Positive_regulation of Transcription of Cdk5 1 0.12 1.65 0.29
21 INT247949 Cdk5r1 Positive_regulation of Cdk5 1 0.26 1.12 0.28
22 INT337113 Ppp1r1b Negative_regulation of Phosphorylation of Cdk5 1 0.11 0.28 0.27
23 INT238632 Binding of EPB41 and Cask 1 0.44 0.78 0.27
24 INT32147 LLGL1 Positive_regulation of Gene_expression of IFNA1 1 0.13 0 0.27
25 INT32149 Binding of ENG and LLGL1 1 0.11 0 0.26
26 INT274942 Binding of Dlg1 and Ephb6 1 0.05 0 0.25
27 INT318980 Binding of CALR and Positive_regulation of Localization of GOPC 1 0.04 0.32 0.24
28 INT273232 Negative_regulation of Binding of Cdk5 and Cdk5r1 1 0.28 3.16 0.23
29 INT273237 Cdk5 Positive_regulation of Protein_catabolism of Grin2b 1 0.45 1.31 0.22
30 INT326834 Cdk5r2 Positive_regulation of Cdk5 1 0.02 0.96 0.21
31 INT139565 Negative_regulation of Binding of PLEK and Tbxa2r 1 0.01 0.57 0.19
32 INT221956 CDK5R1 Regulation of Positive_regulation of CDK5 1 0.21 0.62 0.19
33 INT256985 Binding of Dlg1 and Cd81 1 0.39 0.2 0.17
34 INT298998 Il18 Positive_regulation of Cdk5 1 0.11 0.36 0.17
35 INT164791 Cdk5r1 Positive_regulation of Cdk5 1 0.30 0.25 0.17
36 INT354114 Binding of CALR and SST 1 0.01 0.1 0.16
37 INT293698 Positive_regulation of Binding of Akt1 and Plek 1 0.05 0.12 0.15
38 INT293695 Binding of Akt1 and Plek 1 0.03 0.12 0.15
39 INT293699 Regulation of Binding of Akt1 and Plek 1 0.04 0.12 0.15
40 INT273233 Negative_regulation of Cdk5 Negative_regulation of Positive_regulation of Ltp 1 0.20 0.39 0.13
41 INT273239 Cdk5 Positive_regulation of Positive_regulation of GRIN1 1 0.51 0.37 0.12
42 INT265919 Binding of PLEK and Adp 1 0.01 0.38 0.11
43 INT221958 CDK5R1 Positive_regulation of Positive_regulation of CDK5 1 0.36 0.38 0.1
44 INT273236 Cdk5 Positive_regulation of Car2 1 0.13 0.45 0.1
45 INT221959 Binding of CDK5 and CDK5R1 1 0.28 0.53 0.1
46 INT201751 Car2 Positive_regulation of Cdk5 1 0.00 0.67 0.09
47 INT221954 Binding of CDK5 and CDK5R2 1 0.02 0.36 0.09
48 INT192860 Binding of Calr and Esr1 1 0.06 0.67 0.08
49 INT238631 Regulation of Binding of EPB41 and Cask 1 0.29 0.24 0.07
50 INT61385 FANCB Negative_regulation of PLEK 1 0.42 0.13 0.07
51 INT247948 Positive_regulation of Cdk5r1 Positive_regulation of Cdk5 1 0.26 0.16 0.07
52 INT346752 Binding of Dlg1 and Gria1 1 0.02 0 0.06
53 INT210827 Binding of EPB41 and TPM3 1 0.03 0.17 0.06
54 INT213060 Hdl1 Negative_regulation of Gene_expression of PLEK 1 0.25 1.33 0.05
55 INT332329 Binding of Cdk5 and P2rx3 1 0.22 0.05 0.05
56 INT332331 Binding of Cdk5 and Rbm39 1 0.00 0.05 0.05
57 INT335702 Esr1 Regulation of Calr 1 0.03 0 0.04
58 INT347465 Binding of PLEK and ST7L 1 0.01 0 0.04
59 INT326830 Cdk5r1 Positive_regulation of Positive_regulation of Cdk5 1 0.09 0.16 0.04
60 INT335703 Esr1 Regulation of Localization of Calr 1 0.03 0 0.04
61 INT221639 Fyn Positive_regulation of Phosphorylation of Cdk5 1 0.14 0.28 0.03
62 INT221661 Sema3a Positive_regulation of Phosphorylation of Cdk5 1 0.19 0.28 0.03
63 INT332330 Cdk5 Negative_regulation of Pirt 1 0.00 0 0.03
64 INT219352 CDK5 Negative_regulation of PAK1 1 0.22 0.72 0.03
65 INT221613 Binding of Cdk5 and Fyn 1 0.10 0.29 0.03
66 INT221617 Fyn Positive_regulation of Cdk5 1 0.13 0.28 0.03
67 INT308131 PLEK Positive_regulation of F2 1 0.12 0.08 0
68 INT263726 Binding of Dlg1 and Dlg4 1 0.04 0 0
69 INT336994 CALR Negative_regulation of ESR1 1 0.04 0 0
70 INT256988 Binding of Dlg1 and Rpe 1 0.06 0 0
71 INT335705 Binding of ITGA4 and Calr 1 0.01 0.43 0
72 INT281320 Binding of PLEK and St8sia2 1 0.06 0.38 0
73 INT351732 SSD Regulation of CALR 1 0.01 2.95 0
74 INT281322 Binding of PLEK and Tlr4 1 0.15 1.41 0
75 INT263737 Binding of Dlg1 and Neto1 1 0.07 0 0
76 INT307306 Gene_expression of COMP Positive_regulation of CALR 1 0.27 0.99 0
77 INT307305 Gene_expression of COMP Positive_regulation of Positive_regulation of CALR 1 0.27 0.41 0
78 INT201734 Binding of Akt1 and Cdk5 1 0.01 0.31 0
79 INT333928 Binding of CALR and ESR1 1 0.09 0.09 0
80 INT201738 Positive_regulation of Binding of Akt1 and Cdk5 1 0.01 0.31 0
81 INT351733 CALR Positive_regulation of ROS1 1 0.03 0.3 0
82 INT286682 Maob Positive_regulation of Positive_regulation of PLEK 1 0.51 0.89 0
83 INT354487 Binding of F9 and PLEK 1 0.52 0.14 0
84 INT351730 CALR Positive_regulation of Positive_regulation of ROS1 1 0.02 0.72 0
85 INT275985 Binding of PLEK and Gp6 1 0.29 0 0
86 INT270084 Binding of PLEK and PSMG1 1 0.09 0.26 0
87 INT316772 Calr Positive_regulation of Ddit3 1 0.10 0.12 0
88 INT256981 Binding of Dlg1 and Slc9a3r1 1 0.22 0 0
89 INT333931 Binding of CALR and PDIA3 1 0.18 0.18 0
90 INT307309 Binding of CALR and EREG 1 0.00 0.83 0
91 INT304608 Binding of GYPA and Epb4.1 1 0.00 0.4 0
92 INT316771 Calr Positive_regulation of Localization of Ddit3 1 0.10 0.12 0
93 INT201731 Negative_regulation of Binding of Akt1 and Cdk5 1 0.01 0.31 0
94 INT268446 Cdk5 Positive_regulation of Cdk5r1 1 0.02 0.58 0
95 INT279131 LTF Positive_regulation of CALR 1 0.03 2.39 0
96 INT307310 Binding of CALR and COMP 1 0.28 0.82 0
97 INT238630 Negative_regulation of Binding of EPB41 and Cask 1 0.45 0 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for cortical actin cytoskeleton organization. They are ordered first by their pain relevance and then by number of times they were reported in cortical actin cytoskeleton organization. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT9296 Negative_regulation of PLEK 100 0.57 36.65 27.52
2 INT109223 Negative_regulation of Cdk5 14 0.59 3.27 12.73
3 INT12135 Gene_expression of PLEK 62 0.75 34.13 12.47
4 INT18412 Binding of PLEK 49 0.47 17.82 10.72
5 INT3366 Localization of PLEK 44 0.78 15.83 9.55
6 INT101602 Positive_regulation of Cdk5 15 0.70 4.1 8.96
7 INT127555 Negative_regulation of Cdk5 59 0.59 50.2 8.45
8 INT10969 Positive_regulation of PLEK 33 0.67 16.96 8.35
9 INT157580 Phosphorylation of Cdk5 4 0.77 0.73 8.33
10 INT12975 Regulation of PLEK 21 0.60 13.62 8.28
11 INT127556 Positive_regulation of Cdk5 35 0.70 19.6 5.95
12 INT101604 Regulation of Cdk5 10 0.61 2.2 5.53
13 INT148495 Regulation of Cdk5 6 0.58 5.42 3.95
14 INT196733 Gene_expression of Cdk5 25 0.76 18.25 2.64
15 INT138789 Gene_expression of Cdk5 6 0.76 5.19 2.62
16 INT30001 Negative_regulation of Gene_expression of PLEK 8 0.57 3.31 2.47
17 INT54555 Negative_regulation of CALR 10 0.41 4.41 2.4
18 INT148494 Binding of Cdk5 6 0.40 5.97 2.31
19 INT112905 Phosphorylation of Cdk5 15 0.82 2.78 2.3
20 INT157579 Binding of Cdk5 3 0.35 0.47 2.13
21 INT70526 Binding of CALR 11 0.35 7.09 1.97
22 INT21941 Regulation of CALR 7 0.53 3.88 1.96
23 INT148492 Positive_regulation of Binding of Cdk5 1 0.47 0.51 1.86
24 INT158710 Negative_regulation of Binding of Cdk5 1 0.40 0 1.84
25 INT33393 Positive_regulation of Gene_expression of PLEK 9 0.67 7.35 1.65
26 INT98687 Gene_expression of Calr 38 0.61 7.03 1.59
27 INT109222 Positive_regulation of Negative_regulation of Cdk5 2 0.50 0.23 1.39
28 INT158709 Negative_regulation of Phosphorylation of Cdk5 1 0.40 0 1.39
29 INT80086 Regulation of Gene_expression of PLEK 5 0.60 2.79 1.29
30 INT66118 Binding of Calr 4 0.46 1.46 1.26
31 INT167056 Gene_expression of CALR 29 0.75 20.05 1.25
32 INT30002 Negative_regulation of Negative_regulation of PLEK 3 0.42 0.76 1.12
33 INT273221 Positive_regulation of Negative_regulation of Cdk5 8 0.49 9.89 1.03
34 INT209218 Gene_expression of Dlg1 3 0.54 0.42 1.03
35 INT21940 Positive_regulation of CALR 15 0.40 17.42 0.95
36 INT162167 Negative_regulation of Gene_expression of ARF6 1 0.38 0 0.94
37 INT203893 Positive_regulation of Gene_expression of Cdk5 2 0.49 7.12 0.92
38 INT162168 Gene_expression of ARF6 1 0.68 0 0.92
39 INT138788 Positive_regulation of Gene_expression of Cdk5 1 0.49 0.44 0.91
40 INT127452 Positive_regulation of CDK5 5 0.32 1.88 0.87
41 INT203892 Positive_regulation of Positive_regulation of Cdk5 4 0.49 4.02 0.85
42 INT81220 Negative_regulation of Binding of PLEK 5 0.42 2.03 0.84
43 INT36881 Regulation of Positive_regulation of PLEK 2 0.44 1.77 0.84
44 INT219358 Gene_expression of CDK5 9 0.58 5.65 0.81
45 INT138787 Positive_regulation of Positive_regulation of Cdk5 1 0.49 0.38 0.81
46 INT18413 Positive_regulation of Binding of PLEK 3 0.49 1.06 0.77
47 INT3368 Positive_regulation of Localization of PLEK 3 0.45 0.51 0.77
48 INT196790 Localization of Cdk5 6 0.74 2.6 0.67
49 INT177557 Positive_regulation of Calr 12 0.48 5.47 0.61
50 INT42121 Negative_regulation of Localization of PLEK 4 0.42 1.92 0.61
51 INT162801 Localization of CALR 7 0.73 8.69 0.6
52 INT127557 Positive_regulation of Phosphorylation of Cdk5 2 0.50 0.43 0.56
53 INT45916 Regulation of Negative_regulation of PLEK 1 0.44 0 0.54
54 INT3367 Regulation of Localization of PLEK 1 0.44 0.34 0.52
55 INT182136 Regulation of Regulation of PLEK 1 0.44 0.4 0.44
56 INT273218 Negative_regulation of Negative_regulation of Cdk5 1 0.42 3.06 0.37
57 INT323021 Positive_regulation of Regulation of PLEK 1 0.49 0.58 0.37
58 INT221973 Negative_regulation of CDK5 4 0.57 2.26 0.36
59 INT44345 Positive_regulation of Negative_regulation of PLEK 1 0.45 0.05 0.35
60 INT238585 Binding of EPB41 1 0.47 0.06 0.31
61 INT19700 Positive_regulation of Protein_catabolism of PLEK 1 0.49 0.59 0.3
62 INT19699 Protein_catabolism of PLEK 1 0.86 0.58 0.29
63 INT319280 Positive_regulation of Dlg1 1 0.45 0.42 0.28
64 INT326820 Negative_regulation of Positive_regulation of Cdk5 1 0.36 1.27 0.28
65 INT298972 Transcription of Cdk5 1 0.15 1.63 0.28
66 INT195871 Positive_regulation of Gene_expression of CALR 9 0.29 3 0.27
67 INT32154 Gene_expression of LLGL1 1 0.17 0 0.26
68 INT238584 Positive_regulation of Binding of EPB41 1 0.49 0 0.24
69 INT318982 Positive_regulation of Binding of CALR 1 0.09 0.32 0.24
70 INT164788 Regulation of Gene_expression of Cdk5 1 0.27 0.31 0.24
71 INT209224 Binding of Dlg1 3 0.13 0.22 0.23
72 INT222087 Regulation of Calr 3 0.42 0.56 0.22
73 INT210859 Gene_expression of EPB41 8 0.75 1.46 0.21
74 INT42592 Negative_regulation of Transcription of PLEK 1 0.41 0 0.21
75 INT182647 Positive_regulation of EPB41 2 0.01 0.77 0.2
76 INT335675 Localization of Calr 1 0.63 1.23 0.2
77 INT42593 Transcription of PLEK 1 0.67 0 0.2
78 INT219375 Localization of CDK5 4 0.52 2.8 0.19
79 INT221974 Phosphorylation of CDK5 1 0.56 0.99 0.19
80 INT273226 Negative_regulation of Gene_expression of Cdk5 2 0.42 0.79 0.17
81 INT108192 Regulation of Binding of PLEK 1 0.60 0.17 0.17
82 INT177555 Regulation of Gene_expression of Calr 3 0.28 0.82 0.16
83 INT157582 Regulation of Phosphorylation of Cdk5 1 0.26 0.25 0.16
84 INT221972 Regulation of CDK5 1 0.42 1.87 0.16
85 INT177554 Positive_regulation of Gene_expression of Calr 3 0.37 1.08 0.14
86 INT16719 Positive_regulation of Positive_regulation of PLEK 1 0.45 0.13 0.14
87 INT274516 Regulation of EPB41 1 0.01 0.14 0.12
88 INT335686 Regulation of Localization of Calr 1 0.48 0.12 0.12
89 INT326822 Negative_regulation of Phosphorylation of Cdk5 1 0.36 0.43 0.12
90 INT341559 Positive_regulation of Gene_expression of CDK5 1 0.23 0.25 0.11
91 INT274519 Protein_catabolism of EPB41 1 0.01 0.18 0.1
92 INT201655 Negative_regulation of Binding of Cdk5 1 0.06 0.9 0.09
93 INT192855 Transcription of Calr 1 0.11 0.99 0.08
94 INT341567 Negative_regulation of Gene_expression of CDK5 1 0.27 0.24 0.07
95 INT354146 Regulation of Gene_expression of CALR 1 0.04 0.73 0.07
96 INT256975 Binding of Dlg1 7 0.36 0 0.06
97 INT219355 Binding of CDK5 3 0.35 2.02 0.06
98 INT316766 Negative_regulation of Calr 2 0.40 0.71 0.03
99 INT242969 Protein_catabolism of Calr 2 0.68 0.94 0.03
100 INT353546 Positive_regulation of Localization of CALR 1 0.05 0.49 0.03
101 INT307326 Negative_regulation of Gene_expression of CALR 3 0.25 1.78 0
102 INT273277 Phosphorylation of Calr 2 0.56 0.82 0
103 INT256961 Regulation of Gene_expression of Dlg1 1 0.33 0 0
104 INT256978 Positive_regulation of Dlg1 1 0.34 0 0
105 INT256952 Localization of Dlg1 1 0.55 0 0
106 INT335676 Positive_regulation of Localization of Calr 1 0.48 0 0
107 INT180099 Binding of Plek 1 0.02 0 0
108 INT335682 Negative_regulation of Positive_regulation of Calr 1 0.29 0 0
109 INT238583 Regulation of Binding of EPB41 1 0.44 0 0
110 INT307324 Positive_regulation of Positive_regulation of CALR 1 0.25 0.36 0
111 INT268444 Regulation of Positive_regulation of Cdk5 1 0.08 0.66 0
112 INT335679 Negative_regulation of Gene_expression of Calr 1 0.29 0 0
113 INT335685 Negative_regulation of Localization of Calr 1 0.29 0 0
114 INT321735 Negative_regulation of Epb4.1 1 0.42 0.07 0
115 INT307331 Negative_regulation of Positive_regulation of CALR 1 0.29 0.36 0
116 INT274520 Regulation of Positive_regulation of EPB41 1 0.01 0 0
117 INT274518 Positive_regulation of Positive_regulation of EPB41 1 0.01 0 0
118 INT256974 Gene_expression of Dlg1 1 0.50 0.08 0
119 INT335678 Regulation of Binding of Calr 1 0.35 0 0
120 INT263679 Transcription of Dlg1 1 0.12 0.07 0
121 INT307332 Negative_regulation of Localization of CALR 1 0.29 0.72 0
Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox