GO:0030877

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Name beta-catenin destruction complex
Categary Component
Go Slim No
Go Link GO:0030877
Unique Molecular Interactions 153
Total Molecular Interactions 216
Total Single Events 1886
Pain Genes Associated 8

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for beta-catenin destruction complex. They are ordered first by their pain relevance and then by number of times they were reported for beta-catenin destruction complex. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT84886 APC Regulation of PPARD 1 0.51 1.57 1.26
2 INT134049 Jak2 Positive_regulation of Gsk3b 1 0.37 0.22 0.77
3 INT195778 Binding of APC and PROCR 7 0.19 3.78 0.73
4 INT261372 Gsk3b Regulation of Gene_expression of Ifi205 1 0.00 0.24 0.58
5 INT182150 Binding of APC and DCPS 1 0.02 1.14 0.48
6 INT114297 Apc Negative_regulation of Gene_expression of Fcer2a 1 0.03 0.96 0.48
7 INT134046 Jak2 Regulation of Gsk3b 1 0.22 0.13 0.47
8 INT288545 Gsk3b Negative_regulation of gr 1 0.25 0.38 0.38
9 INT84887 APC Negative_regulation of Gene_expression of PPARD 1 0.36 0.55 0.37
10 INT152453 Gsk3b Regulation of Nfkb1 1 0.02 1.68 0.36
11 INT66369 Pomc Regulation of Positive_regulation of Gsk3b 1 0.07 0 0.35
12 INT321366 Gsk3b Regulation of Gene_expression of CYP8B1 1 0.01 0.21 0.33
13 INT195665 APC Negative_regulation of F8 1 0.04 1.53 0.32
14 INT242164 Wnt2 Positive_regulation of Localization of Apc 1 0.13 1.53 0.32
15 INT198566 Ddit4l Regulation of Axin1 1 0.03 1 0.31
16 INT195664 APC Negative_regulation of F5 1 0.08 1.51 0.31
17 INT342810 Binding of Adarb1 and Gsk3b 1 0.00 0.36 0.3
18 INT63122 Binding of APC and Man2a2 1 0.01 0.15 0.3
19 INT289954 Binding of APC and CD28 1 0.03 0.38 0.28
20 INT325530 Positive_regulation of Gsk3b Negative_regulation of Gene_expression of Wnt2 1 0.03 0.63 0.28
21 INT170719 Binding of Grm5 and Siah1a 1 0.01 1.1 0.28
22 INT312894 Binding of Gsk3b and Positive_regulation of Gene_expression of Hdac6 1 0.08 1.3 0.27
23 INT350813 Binding of Apc and Crp 1 0.18 1.12 0.27
24 INT235976 Binding of APC and Trav6-3 2 0.01 2.62 0.24
25 INT235974 Negative_regulation of Binding of APC and Trav6-3 1 0.00 1.15 0.24
26 INT235972 Negative_regulation of Binding of APC and Bcr 1 0.01 1.15 0.24
27 INT235973 Binding of APC and Bcr 1 0.01 1.14 0.24
28 INT109408 Negative_regulation of APC Negative_regulation of Positive_regulation of RASGRP1 1 0.06 0.73 0.23
29 INT250783 APC Negative_regulation of SERPINE1 1 0.06 0.86 0.23
30 INT250782 APC Negative_regulation of F2 1 0.00 0.86 0.23
31 INT316111 APC Negative_regulation of SAE1 1 0.04 1.21 0.22
32 INT195663 APC Negative_regulation of Gene_expression of IL6 1 0.16 1.18 0.22
33 INT270433 PLAT Positive_regulation of Positive_regulation of Gsk3b 1 0.04 0.5 0.21
34 INT316110 Binding of APC and SAE1 1 0.03 1.16 0.2
35 INT121583 Negative_regulation of GSK3A Negative_regulation of Gene_expression of GDF15 1 0.11 0.49 0.2
36 INT170721 Siah1a Regulation of Negative_regulation of Grm2 1 0.22 0 0.18
37 INT261401 Binding of Gsk3b and ADHD1 1 0.00 1.62 0.18
38 INT217074 Binding of Acsm3 and Axin1 1 0.00 5.37 0.17
39 INT334106 APC Negative_regulation of NFKB1 1 0.25 1.37 0.17
40 INT334108 APC Negative_regulation of TNF 1 0.13 1.36 0.17
41 INT170724 Binding of Grm8 and Siah1a 1 0.19 0.11 0.15
42 INT289956 Binding of APC and ICAM1 1 0.04 0.5 0.13
43 INT312893 Gsk3b Positive_regulation of Hdac6 1 0.07 0.65 0.13
44 INT263320 Gsk3b Regulation of Uts2r 1 0.02 0.68 0.13
45 INT242163 Wnt2 Positive_regulation of Regulation of Apc 1 0.13 0.71 0.13
46 INT263318 Akt1 Regulation of Gsk3b 1 0.02 0.75 0.13
47 INT354327 Gsk3b Positive_regulation of Gene_expression of Ide 1 0.17 0.33 0.13
48 INT184603 APC Negative_regulation of Gene_expression of TNF 1 0.09 0.97 0.13
49 INT316190 Apc Negative_regulation of Positive_regulation of Mapk1 1 0.33 0.66 0.12
50 INT184608 APC Regulation of Gene_expression of Nppa 1 0.06 1.11 0.12
51 INT299754 Binding of APC and CTLA4 2 0.08 0.97 0.11
52 INT268634 Ptpn2 Positive_regulation of Positive_regulation of Gsk3b 1 0.02 1.08 0.11
53 INT289768 Akt1 Regulation of Phosphorylation of Gsk3b 1 0.04 0.45 0.11
54 INT268626 Mpz Positive_regulation of Positive_regulation of Gsk3b 1 0.29 1.08 0.11
55 INT32546 Gsk3b Negative_regulation of Localization of Gnrh1 1 0.05 0 0.1
56 INT32547 Gsk3b Negative_regulation of Localization of LH 1 0.04 0 0.1
57 INT262255 Binding of APC and F2R 1 0.05 3 0.1
58 INT270203 Binding of CD28 and Apc 1 0.04 0.58 0.08
59 INT268627 Ptpn2 Positive_regulation of Gsk3b 1 0.02 1.7 0.08
60 INT270197 Binding of Apc and Cd86 1 0.02 0.58 0.08
61 INT270198 Binding of Apc and Cd80 1 0.02 0.58 0.08
62 INT268630 Mpz Positive_regulation of Regulation of Gsk3b 1 0.18 0.57 0.07
63 INT354328 Gsk3b Regulation of Gs 1 0.16 0.84 0.07
64 INT170722 Siah1a Regulation of Gene_expression of Grm8 1 0.24 0 0.07
65 INT354329 Gsk3b Regulation of Gene_expression of Gs 1 0.16 0.84 0.07
66 INT221235 Akt1 Negative_regulation of Gsk3b 1 0.06 0.14 0.06
67 INT176095 Binding of Apc and EC 1 0.04 0.51 0.05
68 INT193966 AKT1 Negative_regulation of Gsk3b 1 0.05 0.75 0.05
69 INT193969 AKT1 Negative_regulation of Phosphorylation of Gsk3b 1 0.05 0.75 0.05
70 INT181814 Gsk3b Regulation of Gata4 1 0.06 0.37 0.05
71 INT120574 Binding of Apc and Egfr 1 0.27 1.02 0.05
72 INT193964 Mapk1 Negative_regulation of Gsk3b 1 0.00 0.74 0.05
73 INT334107 Binding of APC and APCS 1 0.16 1.52 0.04
74 INT290810 Gsk3b Regulation of Arntl 1 0.15 0 0.04
75 INT303092 Gsk3b Positive_regulation of NEUROG2 1 0.01 0.16 0.03
76 INT290808 Gsk3b Positive_regulation of Arntl 1 0.25 0.17 0.03
77 INT234981 Binding of Dsg3 and Negative_regulation of Gsk3b 1 0.07 0.3 0.03
78 INT303083 Rorb Regulation of Gsk3b 1 0.00 0.52 0.03
79 INT268629 Mpz Regulation of Phosphorylation of Gsk3b 1 0.26 1.05 0.03
80 INT303079 Gsk3b Positive_regulation of Cebpg 1 0.08 0.16 0.03
81 INT265906 IGF1 Regulation of Gsk3b 1 0.25 1.31 0.03
82 INT337811 Gene_expression of Gsk3b Positive_regulation of Phosphorylation of Akt1 1 0.37 0.37 0.03
83 INT213034 Hdl1 Positive_regulation of Apc 1 0.08 1.21 0
84 INT290811 Binding of Mgst1 and Gsk3b 1 0.05 0 0
85 INT290807 Positive_regulation of Akt1 Positive_regulation of Phosphorylation of Gsk3b 1 0.14 0 0
86 INT341502 Negative_regulation of Binding of Apc and Pdcd1 1 0.00 0.53 0
87 INT268628 Mpz Positive_regulation of Phosphorylation of Gsk3b 1 0.25 0.43 0
88 INT268635 Mpz Positive_regulation of Gsk3b 1 0.17 0.43 0
89 INT191096 Negative_regulation of Binding of Apc and Esr1 1 0.05 1.07 0
90 INT170723 Binding of Calm2 and Siah1a 1 0.24 0 0
91 INT301675 Binding of APC and HLA-E 1 0.01 1.48 0
92 INT170718 Siah1a Regulation of Grm8 1 0.24 0 0
93 INT290809 Binding of Arntl and Gsk3b 1 0.20 0 0
94 INT287885 Binding of DVL1 and AXIN1 1 0.02 0 0
95 INT286112 Binding of Apc and Afap1 1 0.05 0.71 0
96 INT291335 Positive_regulation of RAF1 Positive_regulation of Phosphorylation of GSK3A 1 0.07 0.88 0
97 INT265233 Binding of APC and FKBP1A 1 0.08 0.41 0
98 INT213007 Hdl1 Regulation of Regulation of Apc 1 0.08 1.24 0
99 INT236724 Binding of AXIN1 and Ctnnd2 1 0.39 1.03 0
100 INT301674 Binding of APC and CD80 1 0.01 0.53 0
101 INT195661 Binding of APC and PROC 1 0.23 0.89 0
102 INT253019 APC Positive_regulation of Protein_catabolism of Pttg1 1 0.06 0 0
103 INT253012 APC Positive_regulation of Binding of Pttg1 1 0.06 0 0
104 INT268342 Binding of APC and ANKS1B 1 0.01 0.92 0
105 INT235077 Akt1 Positive_regulation of Phosphorylation of Gsk3b 1 0.07 0.53 0
106 INT191095 Positive_regulation of Binding of Apc and Esr1 1 0.06 1.08 0
107 INT301677 Binding of APC and CD8A 1 0.03 1.48 0
108 INT265232 Regulation of Binding of APC and FKBP1A 1 0.08 0.41 0
109 INT268395 Binding of APC and Kras 1 0.04 1.21 0
110 INT213009 Hdl1 Positive_regulation of Positive_regulation of Apc 1 0.09 1.14 0
111 INT281610 Positive_regulation of Akt1 Positive_regulation of Gsk3b 1 0.02 0.12 0
112 INT80660 INS Positive_regulation of APC 1 0.32 0.65 0
113 INT283362 AXIN2 Negative_regulation of APC 1 0.10 1.67 0
114 INT230713 Binding of Prkcd and Gsk3b 1 0.34 0 0
115 INT191098 Binding of Apc and Esr1 1 0.04 1.06 0
116 INT195659 APC Positive_regulation of Gene_expression of PROC 1 0.26 0.31 0
117 INT268632 Mpz Regulation of Gsk3b 1 0.22 0 0
118 INT213025 Vtn Positive_regulation of Apc 1 0.01 1.19 0
119 INT213054 Hdl1 Regulation of Apc 1 0.05 1.24 0
120 INT290806 Gene_expression of Akt1 Positive_regulation of Phosphorylation of Gsk3b 1 0.14 0 0
121 INT291331 Negative_regulation of GSK3A Positive_regulation of Positive_regulation of RAF1 1 0.07 0.94 0
122 INT303004 Adm Positive_regulation of Gsk3b 1 0.04 0.97 0
123 INT263319 Binding of Gsk3b and Uts2r 1 0.01 0 0
124 INT80659 Positive_regulation of INS Positive_regulation of APC 1 0.32 0.65 0
125 INT236721 Binding of Apc and Ctnnd2 1 0.25 1.03 0
126 INT252909 FZR1 Positive_regulation of APC 1 0.06 0.08 0
127 INT341501 Binding of Apc and Pdcd1 1 0.00 0.52 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for beta-catenin destruction complex. They are ordered first by their pain relevance and then by number of times they were reported in beta-catenin destruction complex. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT124371 Negative_regulation of Gsk3b 170 0.55 87.92 15.51
2 INT124372 Gene_expression of Gsk3b 164 0.75 95.64 14.35
3 INT135372 Positive_regulation of Gsk3b 72 0.70 50.03 9.28
4 INT57057 Gene_expression of APC 131 0.78 122.24 8.7
5 INT16631 Negative_regulation of APC 46 0.57 30.53 7.11
6 INT3819 Positive_regulation of Apc 36 0.69 27.03 6.02
7 INT124370 Positive_regulation of Gene_expression of Gsk3b 47 0.67 24.56 5.4
8 INT87022 Gene_expression of Apc 68 0.67 46.98 5.22
9 INT57064 Positive_regulation of APC 72 0.66 48.5 5.08
10 INT135374 Binding of Gsk3b 46 0.48 24.36 4.75
11 INT66366 Positive_regulation of Gsk3b 15 0.68 6.56 4.27
12 INT167284 Phosphorylation of Gsk3b 88 0.82 36.03 4.21
13 INT3817 Negative_regulation of Apc 29 0.58 22.12 3.91
14 INT116642 Negative_regulation of Gsk3b 13 0.57 7.16 3.83
15 INT63121 Binding of APC 29 0.41 23.02 3.8
16 INT135373 Regulation of Gsk3b 35 0.62 18.11 3.53
17 INT66367 Gene_expression of Gsk3b 16 0.45 9.75 3.07
18 INT170712 Gene_expression of Siah1a 1 0.77 2.33 2.33
19 INT121589 Negative_regulation of GSK3A 10 0.53 9.11 2.22
20 INT204018 Localization of Gsk3b 27 0.71 13.67 1.87
21 INT3818 Regulation of Apc 13 0.39 12.52 1.68
22 INT220177 Binding of Apc 21 0.37 15.34 1.37
23 INT110434 Positive_regulation of Gene_expression of Apc 20 0.50 11.37 1.3
24 INT167283 Negative_regulation of Phosphorylation of Gsk3b 12 0.59 7.94 1.16
25 INT102073 Regulation of Gene_expression of APC 5 0.45 6.09 1.15
26 INT134036 Regulation of Gsk3b 4 0.60 1.42 1.15
27 INT32545 Localization of Gsk3b 9 0.07 2.88 1.11
28 INT208536 Positive_regulation of Positive_regulation of Gsk3b 6 0.30 4.83 1.11
29 INT102074 Positive_regulation of Gene_expression of APC 20 0.50 13.66 1.1
30 INT116646 Regulation of Negative_regulation of Gsk3b 2 0.44 0.39 0.99
31 INT261360 Binding of Gsk3b 5 0.36 2.85 0.9
32 INT242134 Localization of Apc 8 0.74 4.83 0.88
33 INT167285 Positive_regulation of Phosphorylation of Gsk3b 17 0.50 5.92 0.82
34 INT156945 Positive_regulation of Negative_regulation of Gsk3b 6 0.38 4.58 0.82
35 INT66365 Positive_regulation of Gene_expression of Gsk3b 2 0.07 0.95 0.81
36 INT116644 Phosphorylation of Gsk3b 4 0.61 0.68 0.78
37 INT204002 Negative_regulation of Gene_expression of Gsk3b 15 0.55 8.57 0.77
38 INT57062 Regulation of APC 24 0.58 14.3 0.7
39 INT80674 Negative_regulation of Gene_expression of APC 16 0.59 18.14 0.69
40 INT242137 Negative_regulation of Positive_regulation of Gsk3b 7 0.39 2.99 0.67
41 INT204006 Negative_regulation of Localization of Gsk3b 6 0.40 1.66 0.6
42 INT170695 Binding of Siah1a 1 0.48 1.19 0.59
43 INT230679 Positive_regulation of Binding of Gsk3b 3 0.42 1.42 0.58
44 INT72869 Regulation of Negative_regulation of APC 2 0.36 1.7 0.54
45 INT208537 Regulation of Gene_expression of Gsk3b 4 0.36 2.15 0.52
46 INT151720 Negative_regulation of Positive_regulation of Apc 3 0.37 2.15 0.46
47 INT210125 Regulation of Axin1 1 0.02 2.45 0.46
48 INT288540 Negative_regulation of Binding of Gsk3b 4 0.53 2.12 0.43
49 INT208552 Negative_regulation of Negative_regulation of Gsk3b 3 0.31 1.8 0.43
50 INT152151 Regulation of Gene_expression of Apc 4 0.44 3.87 0.42
51 INT235064 Regulation of Positive_regulation of Gsk3b 3 0.41 1.5 0.42
52 INT204012 Regulation of Negative_regulation of Gsk3b 4 0.42 4.51 0.39
53 INT208538 Regulation of Phosphorylation of Gsk3b 3 0.49 4.49 0.38
54 INT220170 Regulation of Positive_regulation of Apc 1 0.10 0.46 0.35
55 INT66364 Regulation of Positive_regulation of Gsk3b 1 0.07 0 0.35
56 INT118243 Transcription of APC 4 0.45 3.33 0.33
57 INT184605 Positive_regulation of Transcription of APC 2 0.19 2.39 0.33
58 INT225667 Transcription of Apc 3 0.52 3.73 0.32
59 INT195672 Localization of APC 7 0.74 3.76 0.3
60 INT268620 Regulation of Localization of Gsk3b 3 0.35 2.12 0.28
61 INT170714 Regulation of Gene_expression of Siah1a 1 0.61 0.71 0.25
62 INT345254 Positive_regulation of Localization of Gsk3b 2 0.01 0.91 0.24
63 INT204021 Transcription of Gsk3b 8 0.57 2.75 0.23
64 INT268621 Positive_regulation of Localization of Gsk3b 4 0.40 1.54 0.22
65 INT225666 Regulation of Transcription of Apc 1 0.29 0.33 0.22
66 INT116647 Positive_regulation of Phosphorylation of Gsk3b 1 0.37 0.18 0.22
67 INT121586 Positive_regulation of GSK3A 2 0.23 0.86 0.2
68 INT121585 Negative_regulation of Positive_regulation of GSK3A 1 0.11 0.49 0.2
69 INT173166 Negative_regulation of Binding of APC 3 0.40 3.01 0.19
70 INT57065 Negative_regulation of Positive_regulation of APC 3 0.22 2.43 0.17
71 INT228603 Positive_regulation of Positive_regulation of Apc 1 0.24 0.24 0.17
72 INT210123 Localization of Axin1 1 0.04 0.84 0.17
73 INT66933 Binding of AXIN1 6 0.32 1.8 0.16
74 INT263410 Negative_regulation of Axin1 1 0.01 0 0.14
75 INT250790 Negative_regulation of Localization of APC 2 0.13 2.3 0.13
76 INT250792 Positive_regulation of Localization of APC 1 0.15 0.48 0.13
77 INT170700 Positive_regulation of Gene_expression of Siah1a 1 0.50 0.36 0.13
78 INT170710 Negative_regulation of Siah1a 1 0.43 0.1 0.12
79 INT259745 Phosphorylation of GSK3A 6 0.20 3 0.11
80 INT268617 Negative_regulation of Regulation of Gsk3b 3 0.28 1.84 0.11
81 INT170701 Negative_regulation of Localization of Siah1a 1 0.42 0 0.11
82 INT242140 Regulation of Localization of Apc 1 0.12 0.12 0.11
83 INT170696 Localization of Siah1a 1 0.74 0 0.11
84 INT242819 Negative_regulation of Gene_expression of Apc 4 0.37 5.6 0.1
85 INT309869 Regulation of Binding of Gsk3b 1 0.12 0.66 0.1
86 INT170699 Positive_regulation of Siah1a 1 0.50 0.08 0.1
87 INT268372 Phosphorylation of APC 3 0.81 3.39 0.09
88 INT312871 Positive_regulation of Transcription of Gsk3b 2 0.29 0.15 0.09
89 INT294014 Regulation of AXIN1 3 0.24 1.04 0.08
90 INT145364 Negative_regulation of AXIN1 2 0.33 0.52 0.08
91 INT234926 Protein_catabolism of Gsk3b 2 0.58 1.33 0.08
92 INT234906 Positive_regulation of Protein_catabolism of Gsk3b 2 0.33 1.33 0.08
93 INT170698 Regulation of Siah1a 1 0.45 0.36 0.06
94 INT170704 Negative_regulation of Binding of Siah1a 1 0.42 0 0.06
95 INT195679 Positive_regulation of Positive_regulation of APC 6 0.50 4.43 0.05
96 INT235057 Positive_regulation of Negative_regulation of Apc 2 0.30 0.66 0.05
97 INT244699 Positive_regulation of AXIN1 1 0.02 0 0.05
98 INT336062 Regulation of Localization of Gsk3b 1 0.03 0.48 0.04
99 INT242139 Protein_catabolism of Apc 1 0.17 0.27 0.03
100 INT195681 Positive_regulation of Negative_regulation of APC 5 0.47 3.9 0
101 INT268625 Regulation of Transcription of Gsk3b 2 0.15 0 0
102 INT294025 Phosphorylation of AXIN1 2 0.38 0.47 0
103 INT287932 Negative_regulation of Binding of AXIN1 1 0.12 0 0
104 INT337657 Negative_regulation of Negative_regulation of APC 1 0.37 0.99 0
105 INT104591 Negative_regulation of Negative_regulation of Apc 1 0.04 0.16 0
106 INT337673 Regulation of Positive_regulation of APC 1 0.38 1.44 0
107 INT170691 Protein_catabolism of Siah1a 1 0.88 0.34 0
108 INT191087 Regulation of Regulation of Apc 1 0.06 1.02 0
109 INT268441 Regulation of Regulation of Gsk3b 1 0.07 0.72 0
110 INT258227 Positive_regulation of Regulation of GSK3A 1 0.15 0 0
111 INT283365 Positive_regulation of Binding of APC 1 0.50 1.43 0
112 INT260480 Transcription of Gsk3b 1 0.02 3.08 0
113 INT152449 Regulation of Protein_catabolism of Gsk3b 1 0.12 0.49 0
114 INT337667 Regulation of Transcription of APC 1 0.23 1 0
115 INT258225 Regulation of GSK3A 1 0.09 0 0
116 INT286093 Regulation of Binding of Apc 1 0.39 1.08 0
117 INT170688 Regulation of Protein_catabolism of Siah1a 1 0.23 0.17 0
118 INT152451 Regulation of Gene_expression of Gsk3b 1 0.12 0.57 0
119 INT152448 Protein_catabolism of Gsk3b 1 0.28 0.49 0
120 INT287935 Positive_regulation of Binding of AXIN1 1 0.14 0 0
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