GO:0030878

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Name thyroid gland development
Categary Process
Go Slim No
Go Link GO:0030878
Unique Molecular Interactions 211
Total Molecular Interactions 297
Total Single Events 2588
Pain Genes Associated 24

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for thyroid gland development. They are ordered first by their pain relevance and then by number of times they were reported for thyroid gland development. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT250867 Fgf8 Positive_regulation of Protein_catabolism of Ecm1 1 0.06 4.35 2.14
2 INT13940 DNM2 Regulation of Localization of CGA 1 0.11 0 1.86
3 INT57249 GNRH1 Regulation of Regulation of CGA 1 0.20 0 1.74
4 INT19633 GNRH1 Regulation of Localization of CGA 4 0.44 0.82 1.33
5 INT89878 Pdyn Positive_regulation of Gene_expression of Nkx2-5 1 0.35 0 1.29
6 INT48117 GH1 Positive_regulation of CGA 1 0.10 0 1.28
7 INT13098 POMC Regulation of Localization of CGA 1 0.58 0 1.14
8 INT250868 Fgf8 Positive_regulation of Gene_expression of Mmp3 1 0.15 1.73 0.93
9 INT48113 GH1 Positive_regulation of Localization of CGA 1 0.07 0 0.9
10 INT250861 Fgf8 Positive_regulation of Gene_expression of Ptger2 1 0.04 1.51 0.84
11 INT89877 Pdyn Positive_regulation of Nkx2-5 1 0.11 0 0.64
12 INT25248 GNRH1 Regulation of CGA 4 0.30 1.22 0.62
13 INT2687 Negative_regulation of Binding of Thra and SGSM3 1 0.43 0.1 0.62
14 INT144248 CGA Regulation of Positive_regulation of NFKB1 1 0.15 1.66 0.61
15 INT2686 Binding of Thra and SGSM3 1 0.36 0.1 0.61
16 INT144256 CGA Regulation of Gene_expression of NFKB1 1 0.21 1.66 0.61
17 INT2685 S100A6 Positive_regulation of Regulation of Thra 1 0.47 0.09 0.58
18 INT2684 S100A6 Regulation of Regulation of Thra 1 0.45 0.09 0.58
19 INT56117 Agt Positive_regulation of Positive_regulation of CGA 1 0.00 0 0.56
20 INT250852 Fgf8 Negative_regulation of Gene_expression of Ecm1 1 0.04 1.1 0.54
21 INT343913 Binding of FOS and Smad3 1 0.19 0.92 0.54
22 INT57248 ELANE Regulation of Gene_expression of CGA 1 0.05 0 0.52
23 INT18248 Binding of CGA and GNRH1 1 0.15 0.92 0.52
24 INT33505 Oprd1 Regulation of Localization of CGA 1 0.00 0 0.52
25 INT48116 Negative_regulation of GH1 Positive_regulation of CGA 1 0.06 0 0.45
26 INT144245 CGA Negative_regulation of Positive_regulation of NFKB1 1 0.13 0.79 0.45
27 INT44513 PDYN Regulation of Localization of CGA 1 0.00 0 0.4
28 INT13097 POMC Negative_regulation of Localization of CGA 1 0.46 0 0.39
29 INT13077 Tac2 Positive_regulation of NKX2-1 1 0.00 0 0.39
30 INT250870 Fgf8 Positive_regulation of Ecm1 1 0.04 0.79 0.38
31 INT29618 Cga Positive_regulation of Gene_expression of Pomc 1 0.06 0 0.34
32 INT17301 Binding of CGA and Lhb 1 0.00 0 0.33
33 INT280926 Hoxa3 Positive_regulation of Gene_expression of Ccl2 1 0.53 2.61 0.32
34 INT68482 Cga Regulation of Gh 1 0.00 1.89 0.31
35 INT144249 CGA Regulation of Gene_expression of TNF 1 0.13 0.83 0.31
36 INT144242 CGA Negative_regulation of Localization of TNF 1 0.12 0.64 0.3
37 INT144250 CGA Negative_regulation of TNF 1 0.12 0.64 0.3
38 INT250856 Fgf8 Positive_regulation of Localization of Mmp3 1 0.11 0.51 0.3
39 INT41006 GNRH1 Negative_regulation of Localization of CGA 1 0.03 0.87 0.3
40 INT109067 Pdyn Positive_regulation of Gene_expression of NKX2-5 1 0.01 0 0.29
41 INT25028 GNRH1 Positive_regulation of CGA 1 0.03 0 0.29
42 INT25025 Regulation of GNRH1 Positive_regulation of CGA 1 0.03 0 0.29
43 INT250864 Fgf8 Positive_regulation of Positive_regulation of Ptger2 1 0.03 0.55 0.28
44 INT250854 Fgf8 Positive_regulation of Positive_regulation of Mmp3 1 0.11 0.55 0.28
45 INT93952 CGA Positive_regulation of ADCY1 1 0.03 0 0.27
46 INT93953 Negative_regulation of CGA Positive_regulation of ADCY1 1 0.03 0 0.27
47 INT342164 Binding of Csf2 and Nkx2-1 1 0.01 0.52 0.26
48 INT25247 TRH Regulation of CGA 1 0.26 0 0.24
49 INT250873 Fgf8 Positive_regulation of GAG 1 0.55 0.48 0.23
50 INT89470 CGA Regulation of Gene_expression of Lhcgr 1 0.00 0 0.23
51 INT45752 Binding of CGA and Prl 1 0.00 0 0.22
52 INT32565 Nppa Regulation of Localization of CGA 1 0.00 0.07 0.22
53 INT144241 CGA Negative_regulation of Phosphorylation of NFKBIA 1 0.10 0.34 0.22
54 INT144247 CGA Positive_regulation of Protein_catabolism of NFKBIA 1 0.11 0.34 0.22
55 INT144243 CGA Positive_regulation of Phosphorylation of NFKBIA 1 0.11 0.34 0.22
56 INT57250 ELANE Positive_regulation of Localization of CGA 1 0.08 0 0.21
57 INT342163 Nkx2-1 Regulation of Gene_expression of Aqp1 1 0.06 0.51 0.2
58 INT256629 Binding of Ptch1 and Shh 7 0.42 4.22 0.19
59 INT110717 CGA Positive_regulation of Localization of INS 1 0.03 0.5 0.19
60 INT306425 Positive_regulation of Binding of TBX1 and VCF 1 0.02 1.15 0.18
61 INT144252 CGA Positive_regulation of Positive_regulation of NFKB1 1 0.17 0.38 0.17
62 INT306426 Binding of TBX1 and VCF 1 0.01 1.09 0.17
63 INT214691 Binding of CGA and CGB 1 0.01 0.7 0.17
64 INT65677 Binding of CGA and FSHR 2 0.25 0.29 0.16
65 INT45944 Nts Regulation of Localization of Cga 1 0.20 0 0.15
66 INT250863 Fgf8 Positive_regulation of Ptger2 1 0.03 0.19 0.14
67 INT250866 Binding of Fgfr4 and Fgf8 1 0.12 0.35 0.11
68 INT261379 Nsdhl Positive_regulation of Thra 1 0.07 1.12 0.11
69 INT36216 Avp Negative_regulation of Positive_regulation of CGA 1 0.03 0 0.11
70 INT65676 Binding of CGA and PLOD1 3 0.23 1.68 0.1
71 INT324702 PLOD1 Positive_regulation of CGA 1 0.03 1.1 0.1
72 INT147936 CGA Regulation of Gene_expression of FSHR 1 0.31 0.71 0.1
73 INT208938 Positive_regulation of Tacr1 Positive_regulation of Nkx2-5 1 0.17 0 0.1
74 INT250860 Fgf8 Regulation of Localization of Ptger2 1 0.02 0.13 0.1
75 INT250862 Fgf8 Regulation of Localization of Mmp3 1 0.13 0.13 0.1
76 INT41512 Oxt Regulation of Cga 1 0.01 0.09 0.09
77 INT250859 Fgf8 Negative_regulation of Gene_expression of Mmp3 1 0.09 0.12 0.09
78 INT21310 Binding of Gnrh1 and Positive_regulation of Localization of CGA 1 0.00 0 0.09
79 INT250872 Fgf8 Positive_regulation of Mmp3 1 0.11 0.12 0.09
80 INT254641 CGA Positive_regulation of AGT 1 0.17 1.51 0.08
81 INT270464 Binding of Shh and Smo 1 0.07 1.3 0.08
82 INT172568 Gene_expression of GNRH1 Regulation of Localization of CGA 1 0.05 0.66 0.08
83 INT254640 CGA Positive_regulation of REN 1 0.07 1.51 0.08
84 INT45834 CGA Negative_regulation of Localization of Lhb 1 0.00 0 0.08
85 INT208943 Nfkb1 Positive_regulation of Nkx2-5 1 0.11 0.38 0.08
86 INT290906 Shh Positive_regulation of Egfr 1 0.23 0 0.08
87 INT254639 CGA Positive_regulation of Gene_expression of AGT 1 0.18 1.51 0.08
88 INT298349 HES3 Positive_regulation of Shh 1 0.12 0.14 0.07
89 INT4580 Positive_regulation of Thra Positive_regulation of Babr 1 0.00 0 0.07
90 INT303562 Binding of Fgf10 and Fgfr2 1 0.40 0.88 0.07
91 INT290905 Gene_expression of Shh Positive_regulation of Gene_expression of Angpt1 1 0.14 0 0.06
92 INT187671 CGA Negative_regulation of Gene_expression of GNRH1 1 0.01 0 0.06
93 INT311916 Smad3 Negative_regulation of Gene_expression of Mmp13 1 0.12 0.27 0.06
94 INT250865 Binding of Fgf8 and Fgfr3 1 0.18 0.3 0.05
95 INT250855 Binding of Fgfr2 and Fgf8 1 0.12 0.3 0.05
96 INT208945 Nkx2-5 Positive_regulation of Gene_expression of Nppa 1 0.03 0.33 0.05
97 INT353294 Binding of Smad2 and Smad3 1 0.15 0.08 0.04
98 INT353295 Binding of Smad3 and Smad4 1 0.17 0.08 0.04
99 INT305383 Binding of NKX2-5 and FLNA 1 0.10 0.7 0.04
100 INT213563 Binding of Ctnnd2 and Shh 1 0.27 0.09 0.04
101 INT270459 Binding of Shh and Gli1 1 0.02 0.65 0.04
102 INT352014 Shh Positive_regulation of Gene_expression of Pax1 1 0.29 0.07 0.03
103 INT303563 Binding of Fgf10 and Dysf 1 0.00 0.44 0.03
104 INT254852 Binding of Col7a1 and Smad3 1 0.01 0.57 0.03
105 INT311655 Shh Positive_regulation of Gene_expression of Fgf8 1 0.31 0.18 0.03
106 INT270462 Shh Positive_regulation of Ccnd1 1 0.10 0.6 0.03
107 INT213559 Binding of Egf and Shh 1 0.17 0.07 0.03
108 INT269943 Sox17 Regulation of Binding of Smad3 1 0.37 0.12 0
109 INT254849 Negative_regulation of Rhoa Positive_regulation of Phosphorylation of Smad3 1 0.11 0.45 0
110 INT290910 Pkm2 Negative_regulation of Shh 1 0.07 0.06 0
111 INT334921 GNRHR Positive_regulation of Gene_expression of CGA 1 0.01 0.53 0
112 INT250132 Binding of Hoxa3 and Gopc 1 0.07 0 0
113 INT205963 GLI1 Positive_regulation of Negative_regulation of SHH 1 0.22 0.58 0
114 INT314850 Shh Regulation of Atoh7 1 0.45 0.22 0
115 INT269937 Binding of Smad3 and Mgst1 1 0.09 0 0
116 INT290908 Regulation of Shh Positive_regulation of Ntn1 1 0.12 0 0
117 INT300664 Binding of Gla and Thra 1 0.08 0 0
118 INT269919 Sox17 Negative_regulation of Binding of Smad3 1 0.36 0 0
119 INT324705 CGA Positive_regulation of PLOD1 1 0.04 0 0
120 INT290911 Gene_expression of Shh Positive_regulation of Pkm2 1 0.07 0 0
121 INT63243 Gnrh1 Regulation of Localization of CGA 1 0.00 0.33 0
122 INT290904 Shh Positive_regulation of Prkcg 1 0.26 0.06 0
123 INT290900 Prkcg Regulation of Shh 1 0.23 0 0
124 INT272418 CGA Regulation of Gene_expression of PROK1 1 0.01 0.34 0
125 INT334919 GNRH1 Positive_regulation of Gene_expression of CGA 1 0.03 0.52 0
126 INT320528 HOXA5 Regulation of Gene_expression of KRBA1 1 0.01 0.48 0
127 INT331611 NKX2-1 Regulation of Transcription of SFTPB 1 0.01 0.49 0
128 INT269924 Smad3 Regulation of Gene_expression of Cdkn2b 1 0.23 0.26 0
129 INT205960 Binding of PTCH1 and SHH 1 0.21 0.71 0
130 INT290944 Shh Positive_regulation of VEGFA 1 0.04 0.05 0
131 INT269955 Positive_regulation of Binding of Smad3 and Sox17 1 0.39 0.05 0
132 INT270461 Shh Regulation of Gene_expression of Ptch1 1 0.48 0.07 0
133 INT356490 CGA Positive_regulation of Gene_expression of VEGFA 1 0.06 0 0
134 INT254863 Tgfb1 Positive_regulation of Transcription of Smad3 1 0.03 0.23 0
135 INT260131 CGA Negative_regulation of OFC1 1 0.01 0.17 0
136 INT356497 CGA Regulation of Edn1 1 0.02 0 0
137 INT350116 FSHR Positive_regulation of Gene_expression of CGA 1 0.01 1.28 0
138 INT252888 Binding of SLC5A5 and PAX8 1 0.02 0.22 0
139 INT254857 Tgfb1 Positive_regulation of Phosphorylation of Smad3 1 0.03 0.44 0
140 INT205959 Binding of SHH and SMOX 1 0.12 0.72 0
141 INT314866 Binding of Six1 and Sall1 1 0.39 0.76 0
142 INT260134 CGA Positive_regulation of Gene_expression of Nos3 1 0.16 0.13 0
143 INT269921 Binding of Smad3 and Scn4a 1 0.12 0 0
144 INT275232 DUOX2 Positive_regulation of ROS1 1 0.10 0.33 0
145 INT269942 Sox17 Regulation of Smad3 1 0.37 0.12 0
146 INT356489 CGA Positive_regulation of Gene_expression of B4GALNT1 1 0.00 0 0
147 INT218665 Olr811 Negative_regulation of Phosphorylation of Smad3 1 0.01 0.33 0
148 INT270471 Shh Regulation of VEGFA 1 0.39 0.08 0
149 INT290898 Shh Positive_regulation of Nos2 1 0.46 0.05 0
150 INT272520 Gene_expression of Dmpk Positive_regulation of Positive_regulation of Nkx2-5 1 0.02 0.43 0
151 INT74031 Cga Regulation of Transcription of Penk 1 0.02 0.2 0
152 INT269929 Binding of Cdkn2b and Smad3 1 0.18 0.89 0
153 INT7037 CGA Positive_regulation of Pdyn 1 0.00 0 0
154 INT269935 Binding of Smad3 and Scn5a 1 0.13 0 0
155 INT202675 Fgf10 Positive_regulation of Fgfr2 1 0.45 0.07 0
156 INT242102 Nkx2-1 Regulation of Gene_expression of Ttf1 1 0.00 1.55 0
157 INT269930 Binding of Smad3 and Sox17 1 0.40 1.16 0
158 INT26540 CGA Positive_regulation of Gene_expression of Penk 1 0.01 0 0
159 INT270466 Ptch1 Regulation of Gene_expression of Shh 1 0.48 0.07 0
160 INT324706 CGA Positive_regulation of HRASLS 1 0.01 0 0
161 INT270460 Shh Positive_regulation of Gene_expression of Angpt1 1 0.04 0.08 0
162 INT43688 Gnrh1 Positive_regulation of CGA 1 0.06 0 0
163 INT213556 Binding of Eya1 and Six1 1 0.41 0.48 0
164 INT277803 Regulation of GNRH1 Regulation of CGA 1 0.00 0.61 0
165 INT272521 Binding of DMPK and Nkx2-5 1 0.01 0.42 0
166 INT288252 Binding of CGA and NUPL2 1 0.15 1 0
167 INT270470 Shh Regulation of Gene_expression of VEGFA 1 0.39 0.15 0
168 INT290907 Shh Positive_regulation of Ntn1 1 0.32 0.05 0
169 INT205977 Binding of SHH and Ptch1 1 0.31 0.71 0
170 INT269946 Binding of Smad3 and Gopc 1 0.08 0 0
171 INT186247 CGA Regulation of Gene_expression of SOD1 1 0.01 0.35 0
172 INT295431 FSHR Positive_regulation of CGA 1 0.29 0.27 0
173 INT268344 SMAD3 Positive_regulation of SMAD4 1 0.17 0.56 0
174 INT270469 Shh Positive_regulation of VEGFA 1 0.29 0.12 0
175 INT270468 Shh Positive_regulation of Gene_expression of VEGFA 1 0.44 0.08 0
176 INT264737 Hes1 Regulation of Shh 1 0.19 0.13 0
177 INT289669 Negative_regulation of GNRH1 Regulation of Localization of CGA 1 0.06 0 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for thyroid gland development. They are ordered first by their pain relevance and then by number of times they were reported in thyroid gland development. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT1793 Localization of CGA 379 0.81 67.38 114.69
2 INT1794 Regulation of Localization of CGA 136 0.57 13.39 59.07
3 INT7035 Regulation of CGA 87 0.45 29.04 28.45
4 INT2614 Gene_expression of CGA 187 0.78 105.89 24.77
5 INT7113 Negative_regulation of Localization of CGA 71 0.51 17.7 23.42
6 INT4612 Positive_regulation of Localization of CGA 64 0.64 8.51 22.39
7 INT1792 Positive_regulation of CGA 123 0.70 64.73 20.79
8 INT2165 Localization of Cga 41 0.80 4.02 19.53
9 INT8088 Regulation of Localization of Cga 28 0.60 2.37 13.91
10 INT3104 Negative_regulation of CGA 76 0.54 29.81 12.23
11 INT23104 Positive_regulation of Cga 20 0.70 10.35 8.03
12 INT250832 Gene_expression of Fgf8 1 0.77 13.36 6.2
13 INT4577 Negative_regulation of Thra 24 0.56 3.75 4.73
14 INT15837 Binding of CGA 31 0.41 12.06 3.17
15 INT2897 Positive_regulation of Thra 20 0.45 5.17 3.01
16 INT13095 Positive_regulation of Localization of Cga 6 0.69 0.69 2.96
17 INT7976 Regulation of Gene_expression of CGA 8 0.19 1.09 2.71
18 INT2136 Gene_expression of Cga 21 0.77 9.83 2.62
19 INT7034 Regulation of Regulation of CGA 5 0.16 0.17 2.29
20 INT2138 Negative_regulation of Cga 5 0.43 3.37 2.1
21 INT13075 Binding of NKX2-1 6 0.05 0.12 2.08
22 INT29678 Negative_regulation of Localization of Cga 4 0.42 0.06 2.01
23 INT158442 Gene_expression of Nkx2-1 21 0.59 8.47 1.99
24 INT2982 Positive_regulation of Gene_expression of CGA 17 0.59 9.08 1.99
25 INT144973 Gene_expression of Shh 9 0.77 4.32 1.96
26 INT208561 Gene_expression of Shh 51 0.78 9.57 1.77
27 INT250841 Positive_regulation of Gene_expression of Fgf8 1 0.69 3.8 1.72
28 INT33225 Gene_expression of Cga 4 0.75 0.09 1.65
29 INT89865 Gene_expression of Nkx2-5 14 0.75 2.99 1.58
30 INT250114 Gene_expression of Hoxa3 36 0.77 23.04 1.46
31 INT43479 Positive_regulation of Positive_regulation of CGA 9 0.39 4.24 1.46
32 INT250850 Negative_regulation of Gene_expression of Fgf8 1 0.42 2.79 1.33
33 INT2681 Binding of Thra 11 0.32 5.98 1.27
34 INT2682 Regulation of Thra 4 0.55 0.49 1.21
35 INT253191 Positive_regulation of Gene_expression of Shh 2 0.66 2.57 1.14
36 INT78266 Localization of NKX2-1 2 0.73 0.16 1.12
37 INT250840 Negative_regulation of Fgf8 1 0.43 1.92 1.11
38 INT184720 Negative_regulation of Smad3 8 0.55 5.23 1.1
39 INT19277 Gene_expression of Thra 4 0.58 0.68 1.1
40 INT2981 Negative_regulation of Gene_expression of CGA 14 0.42 3.41 1.05
41 INT165530 Positive_regulation of Shh 4 0.69 1.21 1.05
42 INT277461 Positive_regulation of Gene_expression of Fgf8 1 0.24 0.47 1.05
43 INT15040 Gene_expression of NKX2-1 8 0.65 3.95 1.02
44 INT161716 Localization of Nkx2-5 2 0.74 2.17 1.02
45 INT109075 Positive_regulation of Transcription of NKX2-5 1 0.67 0 1.02
46 INT109074 Transcription of NKX2-5 1 0.69 0 1.01
47 INT70101 Negative_regulation of Positive_regulation of Cga 2 0.43 0.07 0.92
48 INT13074 Positive_regulation of NKX2-1 4 0.19 0.86 0.87
49 INT44100 Regulation of Cga 2 0.60 0.35 0.86
50 INT140794 Gene_expression of Smad3 22 0.64 9.41 0.83
51 INT109062 Gene_expression of NKX2-5 7 0.75 3.31 0.82
52 INT258932 Positive_regulation of TBX1 3 0.39 2.73 0.82
53 INT23054 Binding of Cga 4 0.36 2.17 0.78
54 INT35832 Regulation of Cga 1 0.04 0.94 0.74
55 INT15039 Negative_regulation of NKX2-1 3 0.21 0 0.72
56 INT89861 Negative_regulation of Nkx2-5 3 0.19 0.12 0.63
57 INT13096 Positive_regulation of Cga 3 0.69 1.23 0.61
58 INT296583 Gene_expression of Fgf10 3 0.59 2.64 0.57
59 INT296594 Regulation of Fgf10 1 0.15 1.53 0.56
60 INT89869 Negative_regulation of Gene_expression of Nkx2-5 1 0.41 0 0.56
61 INT4102 Positive_regulation of Gene_expression of Cga 3 0.47 0.34 0.52
62 INT156254 Gene_expression of Six1 7 0.67 1.52 0.51
63 INT305390 Negative_regulation of NKX2-5 2 0.37 2.24 0.49
64 INT250845 Protein_catabolism of Fgf8 1 0.98 1.64 0.48
65 INT268007 Gene_expression of Fgf8 8 0.72 1.38 0.47
66 INT206484 Localization of Shh 2 0.75 1.14 0.46
67 INT55850 Negative_regulation of Positive_regulation of CGA 2 0.55 0.08 0.46
68 INT23053 Positive_regulation of Binding of Cga 1 0.05 0.06 0.45
69 INT60429 Regulation of Gene_expression of Cga 1 0.27 0 0.45
70 INT232798 Positive_regulation of Gene_expression of Shh 7 0.70 1.49 0.44
71 INT159221 Negative_regulation of TBX1 4 0.41 4.22 0.43
72 INT277465 Regulation of Gene_expression of Fgf8 2 0.25 0.43 0.43
73 INT65606 Binding of TBX1 2 0.30 3.13 0.41
74 INT148608 Positive_regulation of Positive_regulation of Cga 1 0.03 0.39 0.39
75 INT208559 Negative_regulation of Gene_expression of Shh 8 0.43 1.58 0.38
76 INT44101 Negative_regulation of Cga 1 0.08 0.31 0.38
77 INT218691 Phosphorylation of Smad3 1 0.28 3 0.38
78 INT157804 Phosphorylation of Smad3 18 0.77 8.15 0.35
79 INT15836 Positive_regulation of Binding of CGA 1 0.38 0.54 0.34
80 INT250826 Transcription of Fgf8 1 0.71 0.71 0.34
81 INT105457 Regulation of Binding of CGA 2 0.45 0.48 0.33
82 INT181918 Positive_regulation of SMAD3 6 0.35 2.62 0.31
83 INT140795 Positive_regulation of Gene_expression of Smad3 3 0.48 3.16 0.3
84 INT269082 Gene_expression of TBX1 1 0.14 0.36 0.28
85 INT39197 Positive_regulation of Regulation of CGA 1 0.02 0.24 0.27
86 INT250126 Localization of Hoxa3 4 0.74 1.5 0.26
87 INT232795 Positive_regulation of Shh 2 0.70 3.68 0.26
88 INT208915 Positive_regulation of Nkx2-5 3 0.29 1.02 0.25
89 INT262797 Regulation of Gene_expression of Smad3 2 0.34 2.27 0.25
90 INT250836 Binding of Fgf8 3 0.35 0.66 0.24
91 INT15792 Regulation of Positive_regulation of CGA 2 0.59 0.4 0.24
92 INT306427 Localization of TBX1 1 0.20 1.08 0.23
93 INT306428 Positive_regulation of Localization of TBX1 1 0.14 1.08 0.23
94 INT183062 Gene_expression of SHH 12 0.65 5.28 0.21
95 INT305392 Binding of NKX2-5 1 0.22 0.93 0.21
96 INT250833 Localization of Fgf8 1 0.74 0.46 0.21
97 INT250842 Negative_regulation of Binding of Fgf8 1 0.43 0.33 0.21
98 INT134477 Negative_regulation of SHH 2 0.37 1.13 0.2
99 INT288255 Protein_catabolism of CGA 5 0.75 1.87 0.19
100 INT250111 Negative_regulation of Gene_expression of Hoxa3 2 0.43 1.3 0.19
101 INT295437 Negative_regulation of Protein_catabolism of CGA 1 0.36 0.05 0.19
102 INT157797 Negative_regulation of Phosphorylation of Smad3 3 0.40 0.95 0.17
103 INT232799 Regulation of Gene_expression of Shh 3 0.27 1.04 0.16
104 INT253177 Negative_regulation of Gene_expression of Shh 2 0.55 0.63 0.16
105 INT208925 Positive_regulation of Localization of Nkx2-5 1 0.21 0.14 0.16
106 INT324723 Transcription of CGA 1 0.07 4.35 0.15
107 INT250835 Positive_regulation of Fgf8 1 0.50 0.42 0.14
108 INT146415 Regulation of Nkx2-5 3 0.44 0.91 0.13
109 INT253190 Localization of Shh 2 0.77 1.06 0.13
110 INT158903 Gene_expression of Smad3 2 0.56 0.54 0.13
111 INT158890 Negative_regulation of Gene_expression of Smad3 1 0.42 0.13 0.13
112 INT24324 Regulation of NKX2-1 1 0.03 0.1 0.13
113 INT253183 Negative_regulation of Shh 8 0.55 2.13 0.12
114 INT280917 Regulation of Gene_expression of Hoxa3 1 0.45 2.12 0.12
115 INT162568 Regulation of TBX1 3 0.35 1.54 0.11
116 INT258933 Protein_catabolism of TBX1 1 0.43 0.75 0.11
117 INT208922 Transcription of Nkx2-5 2 0.29 0.36 0.1
118 INT323415 Regulation of NKX2-5 1 0.39 0.71 0.1
119 INT208917 Positive_regulation of Transcription of Nkx2-5 1 0.21 0 0.1
120 INT323416 Localization of NKX2-5 1 0.65 1.75 0.1
121 INT356496 Phosphorylation of CGA 1 0.42 0.49 0.1
122 INT208918 Positive_regulation of Gene_expression of Nkx2-5 3 0.23 0.48 0.09
123 INT270442 Transcription of Shh 1 0.53 0.25 0.09
124 INT41112 Negative_regulation of Regulation of CGA 1 0.19 0.25 0.09
125 INT213515 Binding of Shh 8 0.37 1.92 0.08
126 INT34303 Localization of Cga 1 0.78 0 0.08
127 INT270453 Regulation of Shh 1 0.27 0.83 0.08
128 INT307408 Gene_expression of DUOX2 1 0.23 1.38 0.08
129 INT245059 Localization of PAX8 1 0.51 1.43 0.08
130 INT34304 Negative_regulation of Localization of Cga 1 0.57 0 0.08
131 INT205973 Binding of SHH 3 0.35 1.03 0.07
132 INT256862 Regulation of Shh 1 0.25 0 0.07
133 INT305387 Positive_regulation of Gene_expression of NKX2-5 1 0.31 0.72 0.07
134 INT209181 Negative_regulation of Binding of CGA 1 0.02 0.07 0.07
135 INT265317 Negative_regulation of Gene_expression of Smad3 2 0.41 0.9 0.06
136 INT270445 Positive_regulation of Localization of Shh 1 0.44 0.13 0.05
137 INT262799 Localization of Smad3 6 0.56 2.09 0.04
138 INT181793 Positive_regulation of SHH 3 0.67 2.59 0.04
139 INT250125 Positive_regulation of Hoxa3 2 0.50 0.74 0.04
140 INT208560 Negative_regulation of Shh 2 0.59 2.22 0.04
141 INT184722 Positive_regulation of Smad3 3 0.47 1.22 0.03
142 INT260760 Positive_regulation of Fgf10 2 0.53 0.43 0.03
143 INT271419 Localization of SMAD3 2 0.11 0.13 0.03
144 INT303535 Positive_regulation of Gene_expression of Fgf10 1 0.53 0.34 0.03
145 INT253187 Negative_regulation of Transcription of Shh 1 0.41 0.55 0.03
146 INT253181 Transcription of Shh 1 0.68 0.54 0.03
147 INT254812 Positive_regulation of Phosphorylation of Smad3 1 0.25 0.94 0.03
148 INT254805 Transcription of Smad3 1 0.28 0.76 0.03
149 INT298673 Gene_expression of HOXA5 2 0.49 2.33 0
150 INT265337 Binding of Smad3 2 0.35 1 0
151 INT269913 Positive_regulation of Binding of Smad3 1 0.34 0.3 0
152 INT218693 Negative_regulation of Phosphorylation of Smad3 1 0.19 0.32 0
153 INT210870 Gene_expression of Thra 1 0.35 0.23 0
154 INT329784 Gene_expression of SMAD3 1 0.31 0.41 0
155 INT250120 Negative_regulation of Hoxa3 1 0.40 0.09 0
156 INT320543 Positive_regulation of Gene_expression of HOXA5 1 0.44 0.57 0
157 INT268384 Positive_regulation of Phosphorylation of SMAD3 1 0.29 1.22 0
158 INT242099 Binding of Nkx2-1 1 0.02 1.15 0
159 INT293537 Negative_regulation of Gene_expression of Thra 1 0.24 0.11 0
160 INT46503 Positive_regulation of Negative_regulation of Thra 1 0.07 0 0
161 INT269873 Positive_regulation of Negative_regulation of Smad3 1 0.34 0.31 0
162 INT132330 Regulation of Negative_regulation of CGA 1 0.01 0.08 0
163 INT293535 Regulation of Gene_expression of Thra 1 0.26 0.28 0
164 INT314739 Transcription of TBX1 1 0.32 0.8 0
165 INT290918 Negative_regulation of Positive_regulation of Shh 1 0.41 0.25 0
166 INT268382 Phosphorylation of SMAD3 1 0.34 0.6 0
167 INT324725 Negative_regulation of Transcription of CGA 1 0.04 0.88 0
168 INT250830 Regulation of Protein_catabolism of Fgf8 1 0.45 0.08 0
169 INT311651 Positive_regulation of Fgf8 1 0.46 0.26 0
170 INT230972 Positive_regulation of Gene_expression of SHH 1 0.18 0.07 0
171 INT320550 Transcription of HOXA5 1 0.43 0 0
172 INT254809 Positive_regulation of Transcription of Smad3 1 0.25 0.24 0
173 INT250846 Positive_regulation of Protein_catabolism of Fgf8 1 0.50 0.07 0
174 INT288257 Positive_regulation of Protein_catabolism of CGA 1 0.28 0.43 0
175 INT290929 Binding of Shh 1 0.31 0.1 0
176 INT290927 Regulation of Positive_regulation of Shh 1 0.23 0 0
177 INT307412 Binding of DUOX2 1 0.14 0.96 0
178 INT270449 Negative_regulation of Positive_regulation of Shh 1 0.43 0.24 0
179 INT250127 Regulation of Localization of Hoxa3 1 0.43 0.1 0
180 INT268363 Binding of SMAD3 1 0.20 0.56 0
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