GO:0030900

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Name forebrain development
Categary Process
Go Slim No
Go Link GO:0030900
Unique Molecular Interactions 825
Total Molecular Interactions 1089
Total Single Events 8346
Pain Genes Associated 92

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for forebrain development. They are ordered first by their pain relevance and then by number of times they were reported for forebrain development. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT111758 Binding of Drd2 and Insrr 1 0.01 0.94 4.33
2 INT37162 Binding of Calca and Cckar 1 0.04 0.55 3.01
3 INT111757 Positive_regulation of Binding of Drd2 and Insrr 1 0.02 0.64 2.89
4 INT101926 Binding of Dio1 and Drd2 4 0.28 0.39 1.66
5 INT93470 Notch1 Positive_regulation of Localization of Prkcg 2 0.09 0.31 1.65
6 INT191618 Binding of App and Nf1 1 0.35 3.77 1.65
7 INT111076 Psen1 Regulation of Psenen 1 0.17 0.76 1.58
8 INT40827 Sstr1 Negative_regulation of Localization of Gh1 1 0.13 0 1.58
9 INT266406 Binding of APP and Ager 1 0.00 2.34 1.57
10 INT249498 Src Positive_regulation of Phosphorylation of Grin2b 1 0.22 1.11 1.54
11 INT158711 Cdk5 Positive_regulation of Phosphorylation of Trh 1 0.02 0 1.46
12 INT19012 Ghsr Negative_regulation of Localization of Sstr1 1 0.10 0 1.44
13 INT111759 Binding of Cpe and Drd2 1 0.01 0.32 1.42
14 INT111762 Positive_regulation of Binding of Cpe and Drd2 1 0.02 0.33 1.42
15 INT281479 Drd2 Positive_regulation of Penk 1 0.23 0.4 1.3
16 INT112097 Sstr1 Positive_regulation of Adarb1 1 0.02 0.15 1.29
17 INT98833 Th Regulation of Gene_expression of Drd2 1 0.19 0.64 1.27
18 INT317569 Prkca Positive_regulation of Phosphorylation of Src 1 0.11 0 1.25
19 INT249487 Binding of Ephb1 and Src 1 0.17 0.74 1.23
20 INT301166 LRP2 Regulation of TRD@ 1 0.12 1.93 1.21
21 INT299299 VEGFA Positive_regulation of SRC 1 0.20 0.91 1.2
22 INT108469 Tacr1 Regulation of Transcription of Drd2 1 0.07 0.14 1.2
23 INT120205 Binding of App and Ern1 1 0.05 2.55 1.18
24 INT65373 Notch1 Regulation of Oprd1 1 0.09 0 1.16
25 INT209132 Binding of Drd2 and Riok3 1 0.01 1.57 1.16
26 INT249488 Positive_regulation of Binding of Ephb1 and Src 1 0.23 0.68 1.12
27 INT168529 APP Regulation of FSIP1 2 0.65 2.26 1.07
28 INT121743 Negative_regulation of Src Negative_regulation of Ephb1 1 0.27 0 1.02
29 INT21332 Binding of Drd2 and Gm5195 1 0.01 0.26 1
30 INT317518 Src Regulation of Negative_regulation of Oprm1 1 0.16 0.07 1
31 INT143915 Src Regulation of Rbm39 1 0.03 0.18 0.99
32 INT5107 Gal Positive_regulation of Localization of Sstr1 1 0.09 0 0.98
33 INT275406 Binding of ITIH4 and Ccr5 1 0.09 2.88 0.97
34 INT275390 Binding of Ccr5 and Htatsf1 1 0.01 3.26 0.97
35 INT121744 Src Positive_regulation of Positive_regulation of Ephb1 1 0.35 0 0.96
36 INT5104 Gal Positive_regulation of Sstr1 1 0.06 0 0.96
37 INT122269 Src Negative_regulation of Positive_regulation of Grin2b 1 0.27 0.44 0.92
38 INT159996 Prkcg Regulation of Gene_expression of App 1 0.42 0.32 0.92
39 INT159993 App Regulation of Gene_expression of Bace1 1 0.46 0.32 0.92
40 INT161769 Cck Regulation of Cckar 1 0.27 0.53 0.92
41 INT159994 App Regulation of Gene_expression of Prkcg 1 0.42 0.32 0.92
42 INT254242 TNF Positive_regulation of Gene_expression of DKK1 1 0.14 1.24 0.91
43 INT122266 Src Negative_regulation of Grin2b 1 0.27 0.43 0.91
44 INT149559 Tgfb1 Positive_regulation of Gene_expression of Ccr5 1 0.00 0 0.88
45 INT149560 Tgfb1 Positive_regulation of Ccr5 1 0.00 0 0.88
46 INT249491 Efnb2 Positive_regulation of Phosphorylation of Src 1 0.01 0.5 0.87
47 INT202254 Binding of COMT and DRD2 1 0.41 0.23 0.86
48 INT311612 Binding of Drd2 and Sert1 1 0.12 0.65 0.86
49 INT222243 Negative_regulation of Binding of Trpv1 and Ccr5 1 0.21 0.57 0.86
50 INT222244 Binding of Trpv1 and Ccr5 1 0.19 0.57 0.86
51 INT140985 Gli3 Regulation of Ihh 1 0.29 0.85 0.85
52 INT36008 Negative_regulation of Binding of Drd2 and Prl 1 0.01 2.11 0.85
53 INT167431 Binding of APP and MYO1C 1 0.23 1.38 0.83
54 INT317513 Oprm1 Regulation of Positive_regulation of Src 1 0.09 0.4 0.82
55 INT317570 Oprm1 Regulation of Src 1 0.04 0.4 0.82
56 INT107917 RETNLB Positive_regulation of Gene_expression of App 1 0.01 1.2 0.79
57 INT13428 Gabrd Regulation of Localization of Sstr2 1 0.31 0 0.79
58 INT164364 Binding of DRD2 and SUGT1 2 0.06 0.33 0.77
59 INT181615 SRC Positive_regulation of IRS1 1 0.01 0.98 0.77
60 INT334833 Binding of Drd2 and Ncs1 1 0.05 1.11 0.76
61 INT151339 Positive_regulation of Binding of Drd2 and P9Ehs1 1 0.11 0.22 0.76
62 INT151340 Binding of Drd2 and P9Ehs1 1 0.09 0.22 0.75
63 INT40826 Pomc Negative_regulation of Binding of Sstr1 1 0.05 0 0.74
64 INT327702 Binding of Comt and Drd2 1 0.28 0.27 0.74
65 INT133675 NPY6R Negative_regulation of SRC 1 0.17 0.75 0.74
66 INT144453 Binding of GPM6A and SSTR2 1 0.02 0 0.74
67 INT314203 Nos2 Positive_regulation of Gli3 1 0.19 1.27 0.73
68 INT317547 Src Positive_regulation of Positive_regulation of Grin1 1 0.17 0 0.72
69 INT148453 Gene_expression of Inhbe Positive_regulation of Src 1 0.06 0.68 0.72
70 INT123494 Binding of Egr1 and Ccr5 1 0.04 0.94 0.71
71 INT134476 Cdk5 Regulation of Map2k1 1 0.69 0.88 0.71
72 INT306263 Binding of NFIB and TFAM 1 0.00 1.74 0.7
73 INT99818 IFNG Positive_regulation of Gene_expression of APP 1 0.04 0.82 0.7
74 INT68561 Binding of Gli3 and Ust 1 0.01 0.68 0.68
75 INT249489 Src Negative_regulation of Phosphorylation of Grin2b 1 0.20 0.63 0.66
76 INT2700 Binding of App and Cpe 1 0.00 0 0.63
77 INT209131 Binding of Bcl2a1a and Drd2 1 0.22 0.45 0.62
78 INT333544 CTSB Regulation of Protein_catabolism of APP 1 0.01 0.53 0.62
79 INT118083 Aip Negative_regulation of Phosphorylation of APP 1 0.00 0.75 0.62
80 INT333543 CTSB Regulation of APP 1 0.01 0.53 0.62
81 INT84771 Positive_regulation of Binding of App and Pag1 1 0.17 0.9 0.62
82 INT120203 Binding of App and Il1 1 0.17 1.28 0.59
83 INT120204 Binding of App and Il1f5 1 0.09 1.28 0.59
84 INT100225 Binding of Egf and Src 1 0.01 0.67 0.58
85 INT303652 Binding of SST and SSTR2 1 0.26 0.46 0.57
86 INT84770 Binding of App and Pag1 1 0.13 0.89 0.57
87 INT167618 Rho Regulation of App 1 0.17 0.88 0.55
88 INT45258 SLAMF6 Positive_regulation of Drd2 1 0.00 0 0.55
89 INT167620 Rock2 Regulation of App 1 0.13 0.87 0.55
90 INT215644 Binding of Drd2 and Adora2a 1 0.03 0.23 0.55
91 INT271889 Binding of DRD2 and ANKK1 1 0.23 0.36 0.55
92 INT101087 NTF3 Positive_regulation of Gene_expression of IKZF1 1 0.04 0.3 0.55
93 INT271888 Binding of DRD2 and DNAJC7 1 0.14 0.36 0.55
94 INT303653 Binding of DRD2 and SST 1 0.18 0.45 0.54
95 INT32908 Binding of ADCY1 and Drd2 1 0.00 0 0.54
96 INT118082 APP Positive_regulation of Casp3 1 0.00 0.5 0.54
97 INT204494 Binding of App and Fmr1 1 0.54 4.39 0.54
98 INT25414 Positive_regulation of Drd2 Positive_regulation of Penk 1 0.38 0 0.53
99 INT164262 TGM7 Negative_regulation of E2F1 1 0.16 1.08 0.53
100 INT165045 Drd2 Regulation of Cpe 1 0.07 0 0.52
101 INT165042 Drd2 Regulation of Tac1 1 0.22 0 0.52
102 INT275387 Binding of Lamp1 and Ccr5 1 0.01 1.45 0.52
103 INT275405 Binding of GOLPH3 and Ccr5 1 0.00 1.46 0.52
104 INT171914 MAPK8IP3 Positive_regulation of Gene_expression of MAPK1 1 0.06 1.55 0.52
105 INT165043 Drd2 Regulation of Cck 1 0.20 0 0.52
106 INT20580 Drd2 Regulation of Akr1d1 1 0.02 0.26 0.51
107 INT184874 Drd1a Regulation of Gene_expression of Drd2 1 0.13 0.97 0.51
108 INT160203 Prkcc Positive_regulation of Src 1 0.02 0 0.51
109 INT98737 Src Negative_regulation of Tk1 1 0.22 0.15 0.5
110 INT98735 Src Negative_regulation of Egf 1 0.26 0.15 0.5
111 INT108692 NTF3 Regulation of Gene_expression of IKZF1 1 0.69 0.7 0.49
112 INT65185 Binding of ATRX and Ssr1 1 0.03 1.68 0.49
113 INT70930 Sstr2 Regulation of Localization of Gh1 1 0.15 0 0.49
114 INT165078 Binding of CTSB and Notch1 1 0.00 1.08 0.48
115 INT145260 Binding of CLU and App 1 0.00 0.74 0.46
116 INT163040 E2f1 Positive_regulation of Transcription of Oprm1 1 0.00 0 0.46
117 INT306824 Binding of E2F1 and E2F2 1 0.15 0.15 0.46
118 INT273235 Binding of Cdk5 and Cdk5r1 1 0.24 6.06 0.46
119 INT275407 Binding of ERVW-1 and Ccr5 1 0.00 1.74 0.46
120 INT116934 OPRK1 Positive_regulation of Positive_regulation of SRC 1 0.20 0.17 0.46
121 INT116933 SRC Positive_regulation of JUN 1 0.33 0.15 0.46
122 INT116937 Positive_regulation of OPRK1 Positive_regulation of Positive_regulation of SRC 1 0.20 0.17 0.46
123 INT303651 Binding of SSTR2 and SSTR5 1 0.24 0.23 0.45
124 INT167621 Psenen Positive_regulation of App 1 0.02 0.86 0.44
125 INT148377 PDP1 Positive_regulation of NOTCH1 1 0.44 0.64 0.44
126 INT148378 CP Positive_regulation of NOTCH1 1 0.11 0.64 0.44
127 INT167617 Bace2 Positive_regulation of App 1 0.06 0.87 0.44
128 INT167619 Protein_catabolism of Ppp2cb Positive_regulation of App 1 0.00 0.88 0.44
129 INT302369 Binding of Arx and Dlx1 1 0.34 0 0.43
130 INT16586 Binding of Drd2 and Nts 1 0.12 0 0.43
131 INT191610 Binding of App and Drd3 1 0.20 0.7 0.42
132 INT247599 Tlr4 Positive_regulation of Gene_expression of App 1 0.17 0.39 0.42
133 INT89666 Binding of Adora2a and Drd2 1 0.54 0.4 0.42
134 INT36009 Binding of Drd2 and Prl 1 0.01 1.05 0.42
135 INT139873 Negative_regulation of CTSB Negative_regulation of Gene_expression of App 1 0.00 0.8 0.41
136 INT261652 Binding of MAPK1 and PSEN1 1 0.22 1.25 0.41
137 INT139874 CTSB Negative_regulation of Gene_expression of App 1 0.00 0.8 0.41
138 INT79577 APP Negative_regulation of PENK 1 0.12 0.35 0.4
139 INT78121 Positive_regulation of Binding of App and 20S 1 0.23 0.61 0.4
140 INT78122 Binding of App and 20S 1 0.16 0.61 0.4
141 INT55588 Drd2 Regulation of Transcription of Gad1 1 0.15 0.07 0.4
142 INT55589 Drd2 Regulation of Gad1 1 0.15 0.07 0.4
143 INT278944 ZEB1 Negative_regulation of IL1B 1 0.00 1.09 0.39
144 INT13077 Tac2 Positive_regulation of NKX2-1 1 0.00 0 0.39
145 INT134167 Binding of ADRA2A and APLP1 1 0.09 0.64 0.39
146 INT323967 Il6 Positive_regulation of Gene_expression of App 1 0.10 0.86 0.38
147 INT167946 Binding of SRC and Stat5b 1 0.28 0 0.38
148 INT278960 ZEB1 Negative_regulation of MMP3 1 0.00 1.05 0.38
149 INT334835 Negative_regulation of Binding of Drd2 and Ncs1 1 0.04 0.56 0.38
150 INT278943 ZEB1 Negative_regulation of Gene_expression of MMP3 1 0.00 1.05 0.38
151 INT337890 Per1 Regulation of Nr2f2 1 0.08 0 0.37
152 INT300609 Binding of Ctnnb1 and Wnt2 1 0.02 0.25 0.37
153 INT143917 Binding of Src and Arrb2 1 0.27 0.07 0.37
154 INT156122 Phosphorylation of Src Positive_regulation of Adrbk1 1 0.01 0 0.37
155 INT37247 Binding of Drd1a and Drd2 1 0.20 0 0.37
156 INT78854 APP Positive_regulation of Localization of IL6 1 0.14 0.79 0.37
157 INT60817 Binding of Sstr1 and Bcl2l11 1 0.06 0 0.37
158 INT263380 Binding of Src and Abl1 1 0.21 0 0.37
159 INT353390 Binding of DRD4 and SRC 1 0.25 0.62 0.37
160 INT327708 Binding of Drd1a and Drd2 1 0.12 0.12 0.37
161 INT123511 TIAF1 Positive_regulation of Gene_expression of Ccr5 1 0.00 0.6 0.37
162 INT134168 Binding of ADRA2B and APLP1 1 0.06 0.7 0.37
163 INT143918 Binding of Src and Rbm39 1 0.02 0.07 0.36
164 INT123495 Negative_regulation of Binding of Egr1 and Ccr5 1 0.03 0.48 0.36
165 INT123493 Regulation of Binding of Egr1 and Ccr5 1 0.03 0.48 0.36
166 INT263434 Src Regulation of Abl1 1 0.02 0.29 0.35
167 INT302371 Dlx1 Regulation of Gene_expression of Arx 1 0.28 0 0.35
168 INT168202 Msx1 Negative_regulation of Gene_expression of Mc1r 1 0.21 0.49 0.35
169 INT263382 Src Regulation of Trib3 1 0.00 0.29 0.35
170 INT124378 Prodh2 Positive_regulation of Ctnnb1 1 0.00 0.59 0.35
171 INT127887 SLC6A3 Regulation of Drd2 1 0.34 0.68 0.34
172 INT273234 Negative_regulation of Cdk5 Positive_regulation of Ptprs 1 0.14 1.26 0.34
173 INT324224 Binding of OTX2 and H9 1 0.11 0.17 0.33
174 INT124376 Prodh2 Positive_regulation of App 1 0.00 0.66 0.33
175 INT334836 Ncs1 Regulation of Drd2 1 0.02 0.48 0.33
176 INT124379 Prodh2 Positive_regulation of Localization of App 1 0.00 0.66 0.33
177 INT249490 Phosphorylation of Ephb2 Positive_regulation of Src 1 0.17 0.15 0.33
178 INT109894 Drd2 Positive_regulation of FOS 1 0.01 0 0.33
179 INT356323 Binding of ac and Crhr1 1 0.01 0 0.32
180 INT308667 Binding of Chrm1 and Positive_regulation of Binding of App 1 0.04 1.14 0.32
181 INT348016 Binding of Mapk8 and Mapk8ip3 1 0.04 2.09 0.32
182 INT356312 Binding of ac and ORF61 1 0.00 0 0.32
183 INT147434 Psenen Positive_regulation of APP 1 0.01 0.58 0.32
184 INT353208 NEUROG2 Positive_regulation of Gene_expression of HTR1A 1 0.05 0.35 0.31
185 INT249480 Positive_regulation of Ephb1 Positive_regulation of Phosphorylation of Src 1 0.22 0.23 0.31
186 INT168948 Binding of CCK and CCKAR 1 0.23 0 0.3
187 INT146893 TNF Negative_regulation of Dkk1 1 0.01 1.27 0.3
188 INT143688 Binding of Dlc1 and Trpv1 1 0.01 0.45 0.3
189 INT68977 App Positive_regulation of Localization of Mmp9 1 0.05 0.38 0.3
190 INT135095 Negative_regulation of CTSB Negative_regulation of APP 1 0.00 0.74 0.3
191 INT118239 Binding of CCKAR and CYP2B6 1 0.32 0.19 0.29
192 INT100946 TNF Positive_regulation of Localization of NFIB 1 0.01 1.3 0.29
193 INT298995 Il18 Positive_regulation of Gene_expression of Cdk5 1 0.12 1.65 0.29
194 INT207823 SSTR2 Negative_regulation of Localization of GCG 1 0.06 0 0.29
195 INT163903 Binding of EFNB1 and Src 1 0.03 0.56 0.29
196 INT319220 FSIP1 Regulation of APP 1 0.29 1.46 0.29
197 INT299008 Il18 Positive_regulation of Transcription of Cdk5 1 0.12 1.65 0.29
198 INT75056 Binding of MC1R and Msx1 1 0.00 0.17 0.29
199 INT100945 TNF Positive_regulation of NFIB 1 0.00 1.29 0.29
200 INT118853 Negative_regulation of SRC Negative_regulation of Positive_regulation of STAT3 1 0.41 0.08 0.28

Single Events

The table below shows the top 100 pain related interactions that have been reported for forebrain development. They are ordered first by their pain relevance and then by number of times they were reported in forebrain development. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT65500 Gene_expression of App 605 0.78 429.94 98.31
2 INT16455 Gene_expression of Drd2 116 0.78 22.71 38.47
3 INT13501 Binding of Drd2 65 0.48 23.76 35.6
4 INT6683 Gene_expression of Drd2 64 0.78 11.31 32.28
5 INT11087 Positive_regulation of Drd2 54 0.69 12.4 31.43
6 INT29743 Negative_regulation of App 91 0.59 65.56 31.26
7 INT47712 Positive_regulation of App 135 0.69 101.38 28.94
8 INT5097 Localization of Sstr1 30 0.64 0.38 27.92
9 INT5604 Positive_regulation of Drd2 47 0.67 10.75 27.41
10 INT89662 Positive_regulation of Gene_expression of App 169 0.70 133.36 25.62
11 INT12484 Binding of Drd2 45 0.48 15.17 24.72
12 INT44954 Gene_expression of APP 191 0.78 105.86 23.9
13 INT7715 Regulation of Drd2 35 0.62 10.79 22.3
14 INT11625 Localization of App 98 0.78 55.46 20.86
15 INT49774 Binding of DRD2 48 0.48 17.42 20.73
16 INT16794 Binding of App 103 0.48 64.87 19.79
17 INT65502 Regulation of App 77 0.62 52.05 19.44
18 INT23657 Positive_regulation of APP 64 0.70 39.76 16.68
19 INT111073 Gene_expression of Psen1 167 0.76 78.65 15.83
20 INT26729 Negative_regulation of Drd2 28 0.55 9.32 15.17
21 INT54052 Gene_expression of App 33 0.78 25.08 14.7
22 INT5599 Regulation of Drd2 25 0.52 3.07 13.31
23 INT89842 Phosphorylation of Src 34 0.69 9.57 13.08
24 INT109223 Negative_regulation of Cdk5 14 0.59 3.27 12.73
25 INT129883 Gene_expression of Dkk1 56 0.77 45.42 12.52
26 INT29745 Binding of APP 47 0.48 26.49 12.4
27 INT107916 Protein_catabolism of App 114 1.00 66.71 12.38
28 INT53866 Gene_expression of Sstr4 17 0.77 6.67 11.83
29 INT65501 Regulation of Gene_expression of App 56 0.62 32.51 11.48
30 INT98789 Negative_regulation of Gene_expression of App 54 0.58 40.27 11.15
31 INT63773 Gene_expression of DRD2 25 0.78 10.41 10.8
32 INT87393 Gene_expression of Ccr5 19 0.65 11 10.51
33 INT13423 Localization of Sstr2 17 0.78 0.56 10.47
34 INT57039 Positive_regulation of Gene_expression of Drd2 16 0.50 1.98 9.48
35 INT17764 Negative_regulation of Drd2 17 0.42 4.63 9.46
36 INT41569 Regulation of APP 32 0.62 17.15 9.4
37 INT13296 Transcription of Drd2 17 0.66 2.7 9.07
38 INT89845 Positive_regulation of Src 19 0.44 7.5 9.01
39 INT101602 Positive_regulation of Cdk5 15 0.70 4.1 8.96
40 INT6682 Regulation of Gene_expression of Drd2 13 0.51 2.17 8.82
41 INT91772 Gene_expression of PSEN1 115 0.75 38.12 8.48
42 INT127555 Negative_regulation of Cdk5 59 0.59 50.2 8.45
43 INT18194 Positive_regulation of Localization of Sstr1 5 0.40 0 8.41
44 INT157580 Phosphorylation of Cdk5 4 0.77 0.73 8.33
45 INT18190 Regulation of DRD2 11 0.60 9.01 7.63
46 INT75063 Regulation of Gene_expression of Drd2 10 0.62 2.82 7.38
47 INT56031 Positive_regulation of App 25 0.69 13.46 7.37
48 INT82610 Positive_regulation of SRC 53 0.67 26.89 7.27
49 INT84932 Negative_regulation of APP 29 0.57 28.45 7.2
50 INT73760 Transcription of Drd2 14 0.72 2.11 7.19
51 INT90461 Negative_regulation of DRD2 21 0.53 8.35 6.55
52 INT24460 Localization of Drd2 12 0.73 2.96 6.46
53 INT86772 Localization of Drd2 14 0.80 1.93 6.17
54 INT5094 Negative_regulation of Localization of Sstr1 8 0.36 0 5.98
55 INT127556 Positive_regulation of Cdk5 35 0.70 19.6 5.95
56 INT103880 Positive_regulation of DRD2 9 0.67 5.57 5.93
57 INT111069 Regulation of Psen1 19 0.44 7.78 5.87
58 INT60724 Gene_expression of Psen2 30 0.72 27 5.79
59 INT103847 Positive_regulation of Ccr5 11 0.55 6.04 5.79
60 INT6681 Positive_regulation of Gene_expression of Drd2 10 0.65 1.78 5.78
61 INT123726 Positive_regulation of Notch1 23 0.70 7.2 5.65
62 INT102836 Binding of LRP2 12 0.38 11.27 5.58
63 INT101604 Regulation of Cdk5 10 0.61 2.2 5.53
64 INT40719 Binding of Sstr1 7 0.25 0.1 5.49
65 INT82611 Negative_regulation of SRC 30 0.57 20.16 5.47
66 INT100222 Binding of Src 9 0.26 5.41 5.37
67 INT107173 Phosphorylation of App 20 0.82 12.64 5.3
68 INT23725 Gene_expression of CCKAR 14 0.55 0.14 5.3
69 INT18195 Regulation of Localization of Sstr1 5 0.33 0 5.24
70 INT32432 Positive_regulation of Binding of Drd2 7 0.67 2.72 5.19
71 INT99823 Positive_regulation of Gene_expression of APP 31 0.70 21.52 5.09
72 INT115816 Protein_catabolism of APP 35 0.99 20.14 5.06
73 INT89844 Positive_regulation of Phosphorylation of Src 10 0.43 4.71 4.95
74 INT100220 Negative_regulation of Src 13 0.41 6.37 4.93
75 INT68559 Negative_regulation of Gli3 5 0.37 4.56 4.93
76 INT302338 Gene_expression of Arx 1 0.77 2.8 4.93
77 INT131692 Negative_regulation of Localization of App 9 0.53 4.69 4.82
78 INT18193 Positive_regulation of Sstr1 6 0.31 1.82 4.8
79 INT14125 Positive_regulation of Positive_regulation of Drd2 3 0.35 0.85 4.78
80 INT98453 Positive_regulation of Src 19 0.47 7.84 4.62
81 INT337882 Gene_expression of Nr2f2 1 0.76 3.45 4.6
82 INT78116 Positive_regulation of Gene_expression of App 12 0.70 10.78 4.52
83 INT71676 Transcription of DRD2 5 0.69 1.19 4.47
84 INT69217 Gene_expression of Notch1 20 0.78 7.8 4.41
85 INT36007 Negative_regulation of Binding of Drd2 7 0.57 3.22 4.36
86 INT111156 Negative_regulation of Dkk1 21 0.58 20.08 4.27
87 INT58003 Localization of APP 32 0.80 13.75 4.2
88 INT111067 Positive_regulation of Gene_expression of Psen1 32 0.68 21.2 4.19
89 INT173910 Gene_expression of LRP2 24 0.75 19.99 4.09
90 INT24805 Gene_expression of Sstr1 4 0.37 1 4.06
91 INT148495 Regulation of Cdk5 6 0.58 5.42 3.95
92 INT99821 Negative_regulation of Gene_expression of APP 20 0.42 15.21 3.94
93 INT140542 Gene_expression of SSTR2 18 0.65 13.58 3.94
94 INT103843 Positive_regulation of Gene_expression of Ccr5 5 0.42 2.31 3.89
95 INT229912 Phosphorylation of Fyn 5 0.42 2.57 3.78
96 INT53865 Localization of Sstr4 5 0.14 0.8 3.77
97 INT122323 Positive_regulation of NOTCH1 36 0.70 35.63 3.7
98 INT13425 Positive_regulation of Localization of Sstr2 4 0.67 0.19 3.65
99 INT11627 Positive_regulation of Localization of App 14 0.62 6.27 3.64
100 INT99819 Negative_regulation of Positive_regulation of APP 6 0.58 4.41 3.64
101 INT122327 Regulation of Src 6 0.59 0.59 3.6
102 INT67726 Gene_expression of Notch1 36 0.75 9.77 3.54
103 INT23728 Negative_regulation of CCKAR 6 0.42 0.48 3.53
104 INT132385 Gene_expression of Neurog2 12 0.73 7.03 3.44
105 INT70089 Negative_regulation of Binding of APP 7 0.59 6.45 3.44
106 INT40653 Gene_expression of Sstr2 6 0.54 1.28 3.43
107 INT137350 Phosphorylation of Src 13 0.45 4.14 3.32
108 INT211591 Negative_regulation of PSEN1 14 0.57 5.73 3.26
109 INT102209 Negative_regulation of Gene_expression of Drd2 5 0.59 0.46 3.17
110 INT85484 Positive_regulation of Gene_expression of Sstr4 3 0.68 1.52 3.13
111 INT13422 Regulation of Localization of Sstr2 4 0.44 0 3.1
112 INT100688 Gene_expression of SRC 28 0.75 15.51 3.08
113 INT91761 Gene_expression of PSEN2 38 0.75 22.93 3.03
114 INT141180 Gene_expression of Apaf1 6 0.74 5.77 2.98
115 INT108773 Negative_regulation of Binding of App 10 0.42 7.26 2.96
116 INT193936 Positive_regulation of PSEN1 5 0.58 11.57 2.95
117 INT54055 Regulation of Gene_expression of App 7 0.62 4.04 2.93
118 INT101567 Gene_expression of Ctnnb1 7 0.64 10.11 2.89
119 INT85947 Regulation of Cckar 2 0.36 2.4 2.86
120 INT139872 Regulation of Notch1 14 0.45 7.69 2.82
121 INT178772 Transcription of App 17 0.70 10.79 2.79
122 INT147429 Negative_regulation of Positive_regulation of App 8 0.40 8.73 2.78
123 INT54054 Binding of App 4 0.48 10.89 2.78
124 INT119025 Gene_expression of NOTCH1 46 0.75 31.32 2.64
125 INT196733 Gene_expression of Cdk5 25 0.76 18.25 2.64
126 INT138789 Gene_expression of Cdk5 6 0.76 5.19 2.62
127 INT87395 Binding of Ccr5 5 0.29 2.5 2.6
128 INT225253 Positive_regulation of Phosphorylation of Src 4 0.38 2.36 2.59
129 INT111153 Positive_regulation of Dkk1 13 0.68 10.56 2.58
130 INT50320 Transcription of Sstr1 3 0.43 0.53 2.58
131 INT108468 Negative_regulation of Gene_expression of Drd2 3 0.41 0.67 2.58
132 INT23534 Regulation of CCKAR 8 0.32 0.17 2.56
133 INT19006 Negative_regulation of Sstr1 5 0.28 0.1 2.55
134 INT125439 Positive_regulation of NFIB 4 0.67 6.71 2.52
135 INT126581 Positive_regulation of Gli3 6 0.35 1.59 2.48
136 INT130476 Phosphorylation of Fyn 8 0.80 2.99 2.44
137 INT163544 Binding of Psen1 40 0.36 15.28 2.42
138 INT32920 Gene_expression of Msx1 19 0.71 4.24 2.42
139 INT40505 Positive_regulation of CCKAR 3 0.40 0 2.42
140 INT188255 Gene_expression of DKK1 19 0.60 12.69 2.39
141 INT162513 Regulation of Protein_catabolism of APP 5 0.51 1.79 2.36
142 INT11626 Regulation of Localization of App 4 0.45 1.51 2.34
143 INT56030 Regulation of App 8 0.62 4.06 2.32
144 INT13421 Positive_regulation of Sstr2 5 0.54 0.46 2.32
145 INT148494 Binding of Cdk5 6 0.40 5.97 2.31
146 INT112905 Phosphorylation of Cdk5 15 0.82 2.78 2.3
147 INT29402 Gene_expression of Src 16 0.74 4.57 2.29
148 INT163283 Gene_expression of E2F1 21 0.71 3.77 2.26
149 INT18196 Regulation of Sstr1 3 0.34 0 2.26
150 INT103881 Positive_regulation of Binding of DRD2 4 0.69 2.01 2.18
151 INT96743 Transcription of Ccr5 2 0.54 2.72 2.17
152 INT49769 Binding of SSTR2 4 0.48 1.39 2.14
153 INT50057 Regulation of Notch1 3 0.39 0.87 2.14
154 INT157579 Binding of Cdk5 3 0.35 0.47 2.13
155 INT17688 Positive_regulation of IKZF1 5 0.50 0.48 2.11
156 INT124772 Regulation of Binding of App 6 0.45 4.92 2.09
157 INT13075 Binding of NKX2-1 6 0.05 0.12 2.08
158 INT337864 Positive_regulation of Gene_expression of Nr2f2 1 0.68 0.48 2.07
159 INT39008 Localization of App 13 0.77 9.07 2.05
160 INT181507 Positive_regulation of Psen1 22 0.49 7.59 2.04
161 INT126374 Gene_expression of Gli3 6 0.77 3.67 2.02
162 INT60723 Localization of Psen2 5 0.68 2.11 2.02
163 INT25411 Positive_regulation of Positive_regulation of Drd2 2 0.48 0.5 1.98
164 INT81641 Gene_expression of Ctnnb1 23 0.72 14.93 1.97
165 INT262364 Positive_regulation of LRP2 6 0.39 4.44 1.97
166 INT144973 Gene_expression of Shh 9 0.77 4.32 1.96
167 INT193939 Binding of PSEN1 10 0.36 6.16 1.93
168 INT142774 Regulation of Phosphorylation of App 1 0.59 2.27 1.93
169 INT249530 Positive_regulation of Positive_regulation of Src 3 0.28 1.32 1.9
170 INT98464 Positive_regulation of Positive_regulation of SRC 10 0.67 5.71 1.86
171 INT140036 Positive_regulation of Gene_expression of Notch1 6 0.61 2 1.86
172 INT148492 Positive_regulation of Binding of Cdk5 1 0.47 0.51 1.86
173 INT141191 Positive_regulation of Gene_expression of Apaf1 1 0.48 2.33 1.85
174 INT52633 Negative_regulation of Notch1 4 0.42 2.99 1.84
175 INT158710 Negative_regulation of Binding of Cdk5 1 0.40 0 1.84
176 INT63724 Positive_regulation of Sstr4 2 0.06 0.65 1.81
177 INT30373 Localization of CCKAR 5 0.68 0.17 1.79
178 INT121117 Regulation of Protein_catabolism of App 10 0.62 6.41 1.78
179 INT208561 Gene_expression of Shh 51 0.78 9.57 1.77
180 INT111070 Negative_regulation of Gene_expression of Psen1 17 0.42 9.47 1.77
181 INT139475 Negative_regulation of DKK1 14 0.52 9.2 1.76
182 INT107915 Regulation of Negative_regulation of App 6 0.45 4.47 1.76
183 INT87394 Negative_regulation of Ccr5 3 0.32 1.3 1.74
184 INT120088 Gene_expression of Bmp4 37 0.73 13.89 1.73
185 INT82609 Phosphorylation of SRC 17 0.80 6.45 1.7
186 INT40863 Negative_regulation of Sstr2 2 0.57 0.15 1.7
187 INT50090 Negative_regulation of Sstr4 3 0.42 0 1.68
188 INT146943 Gene_expression of Src 13 0.49 6.65 1.65
189 INT107485 Regulation of Sstr2 1 0.35 1.16 1.65
190 INT123990 Positive_regulation of Ctnnb1 8 0.43 2.85 1.63
191 INT99391 Localization of Ctnnb1 7 0.80 5.84 1.61
192 INT344978 Negative_regulation of Gene_expression of Dkk1 1 0.58 4.38 1.59
193 INT101090 Gene_expression of IKZF1 6 0.77 2.98 1.58
194 INT6830 Positive_regulation of Notch1 20 0.55 7.91 1.57
195 INT133863 Positive_regulation of Protein_catabolism of App 12 0.59 7.53 1.52
196 INT282434 Regulation of Gene_expression of Psen1 9 0.50 2.85 1.52
197 INT163381 Transcription of Notch1 2 0.69 0.41 1.52
198 INT58004 Positive_regulation of Localization of APP 5 0.46 2.1 1.5
199 INT98455 Regulation of Src 4 0.20 1.76 1.48
200 INT140245 Binding of Gli3 3 0.36 2.65 1.46
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