GO:0030901

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Name midbrain development
Categary Process
Go Slim No
Go Link GO:0030901
Unique Molecular Interactions 197
Total Molecular Interactions 264
Total Single Events 1515
Pain Genes Associated 28

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for midbrain development. They are ordered first by their pain relevance and then by number of times they were reported for midbrain development. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT180785 Gdnf Positive_regulation of Calca 1 0.23 1.96 8.04
2 INT180774 Gdnf Positive_regulation of Trpv1 1 0.33 2.43 4.37
3 INT122776 Gdnf Positive_regulation of Gene_expression of Trpv1 2 0.67 2.13 3.06
4 INT103330 Ngf Positive_regulation of Gdnf 2 0.28 1.27 2.45
5 INT122775 Gdnf Regulation of Gene_expression of Trpv1 4 0.59 2.72 2.42
6 INT115042 Gdnf Regulation of Calca 1 0.53 0.25 2.03
7 INT180812 Gdnf Positive_regulation of Gene_expression of Sorbs1 1 0.02 0.83 1.61
8 INT180811 Gdnf Positive_regulation of Regulation of Sorbs1 1 0.01 0.83 1.61
9 INT180791 Negative_regulation of Gdnf Regulation of Calca 1 0.17 0 1.47
10 INT180790 Gdnf Regulation of Localization of Trpv1 1 0.15 1.21 1.43
11 INT83197 Binding of Ntrk1 and Gdnf 1 0.01 1.05 1.36
12 INT180802 Gdnf Positive_regulation of Sorbs1 1 0.02 0.98 1.34
13 INT180764 Calca Regulation of Positive_regulation of Gdnf 1 0.21 0 1.32
14 INT148435 Binding of Bdnf and Gdnf 2 0.35 1.9 1.17
15 INT180814 Binding of Ret and Gdnf 1 0.01 1.31 1.17
16 INT180770 Gdnf Positive_regulation of Zbtb38 1 0.00 0.27 0.99
17 INT147504 Binding of Ncam1 and Gdnf 1 0.31 0.87 0.98
18 INT180780 Ngf Regulation of Gdnf 1 0.22 0.28 0.96
19 INT180803 Sorbs1 Regulation of Gdnf 1 0.01 0.28 0.95
20 INT180787 Calca Regulation of Gdnf 1 0.18 0.28 0.95
21 INT147505 Binding of Ret and Gdnf 1 0.27 0.81 0.92
22 INT183176 Binding of FGFR2 and NUDT6 1 0.05 1.07 0.84
23 INT103331 Ngf Positive_regulation of Gdnf 1 0.01 0.57 0.8
24 INT103334 Gdnf Regulation of Gene_expression of TRPV1 1 0.02 0.53 0.77
25 INT103333 Gdnf Regulation of TRPV1 1 0.02 0.53 0.77
26 INT146780 Positive_regulation of Fgfr1 Positive_regulation of Mapk14 1 0.34 0.95 0.77
27 INT180773 Calca Regulation of Binding of Gdnf 1 0.18 0.15 0.72
28 INT180783 Binding of Gdnf and Man2a2 1 0.00 0.52 0.71
29 INT180775 Binding of Gdnf and Gfra1 1 0.06 0.52 0.71
30 INT102121 Gdnf Regulation of Gene_expression of Cnr1 1 0.45 0.42 0.71
31 INT122777 Gdnf Negative_regulation of Gene_expression of Trpv1 1 0.36 0.8 0.62
32 INT122774 Gdnf Negative_regulation of Positive_regulation of Trpv1 1 0.32 0.78 0.61
33 INT91267 Gdnf Negative_regulation of Gdnf 1 0.05 0.81 0.58
34 INT353978 Lmx1b Regulation of Gene_expression of Pet1 1 0.31 0.21 0.53
35 INT356279 Gdnf Regulation of Positive_regulation of Mapk1 1 0.03 0.76 0.5
36 INT98117 Gdnf Regulation of SCN11A 1 0.05 0.39 0.5
37 INT98116 Gdnf Regulation of SCN10A 1 0.03 0.39 0.5
38 INT104459 Gdnf Regulation of Ngf 1 0.26 0.56 0.45
39 INT127074 Gdnf Regulation of Gene_expression of Jun 1 0.10 0.28 0.43
40 INT127072 Gdnf Regulation of Gene_expression of Fos 1 0.38 0.28 0.43
41 INT127077 Gdnf Positive_regulation of Gene_expression of IER3 1 0.02 0.26 0.42
42 INT127079 Gene_expression of Gdnf Positive_regulation of Gene_expression of IER3 1 0.02 0.26 0.42
43 INT228055 WNT1 Positive_regulation of CTNND2 1 0.54 1.75 0.42
44 INT148436 Binding of Gdnf and Ngf 1 0.35 1.14 0.4
45 INT43363 Scd1 Regulation of Barhl1 1 0.03 0.07 0.39
46 INT140869 Binding of Gdnf and Trib3 1 0.04 0.15 0.37
47 INT168202 Msx1 Negative_regulation of Gene_expression of Mc1r 1 0.21 0.49 0.35
48 INT324224 Binding of OTX2 and H9 1 0.11 0.17 0.33
49 INT356278 Gdnf Positive_regulation of Mapk1 1 0.05 0.17 0.3
50 INT356282 Gdnf Positive_regulation of Trib3 1 0.00 0.17 0.3
51 INT75056 Binding of MC1R and Msx1 1 0.00 0.17 0.29
52 INT180788 Gdnf Regulation of Trpv1 1 0.13 0.2 0.28
53 INT168203 Binding of Mc1r and Msx1 1 0.19 0.64 0.25
54 INT353981 Gene_expression of Pet1 Positive_regulation of Lmx1b 1 0.53 0 0.23
55 INT9717 Binding of Egf and Fgfr1 1 0.15 0 0.22
56 INT75057 Binding of POMC and Msx1 2 0.39 0.6 0.2
57 INT297545 Pou3f3 Regulation of Hes1 1 0.05 0.41 0.2
58 INT256629 Binding of Ptch1 and Shh 7 0.42 4.22 0.19
59 INT97547 KITLG Negative_regulation of Msx1 1 0.00 0.08 0.15
60 INT97542 Pomc Negative_regulation of Msx1 1 0.13 0.07 0.15
61 INT97545 Gtf3a Negative_regulation of Msx1 1 0.02 0.08 0.15
62 INT193551 Mtpn Positive_regulation of Gene_expression of Gdnf 1 0.02 0.34 0.13
63 INT193552 Gdnf Positive_regulation of Gene_expression of Mtpn 1 0.02 0.34 0.13
64 INT311905 Binding of Runx2 and Smad1 1 0.12 0.46 0.13
65 INT225024 PDGFB Positive_regulation of Gene_expression of Cxcl5 1 0.16 0.08 0.13
66 INT193548 Gdnf Positive_regulation of Ephb1 1 0.40 0.34 0.13
67 INT311912 Gene_expression of Smad1 Positive_regulation of Gene_expression of Mmp13 1 0.08 0.51 0.12
68 INT141281 ARTN Regulation of Gdnf 1 0.48 0.32 0.12
69 INT214150 Binding of Mc3r and Msx1 1 0.03 0.5 0.12
70 INT141279 Nrtn Regulation of Gdnf 1 0.14 0.32 0.12
71 INT141280 PSPN Regulation of Gdnf 1 0.48 0.32 0.12
72 INT214152 Binding of Mc4r and Msx1 1 0.03 0.24 0.11
73 INT262653 Binding of AICDA and Lmx1a 1 0.00 3.18 0.1
74 INT297548 Neurod1 Regulation of Hes1 1 0.05 0.2 0.1
75 INT262654 Binding of HLA-DQA1 and Lmx1a 1 0.01 3.15 0.1
76 INT287887 WNT1 Positive_regulation of Localization of BMP4 1 0.04 1.13 0.1
77 INT262702 Bace1 Positive_regulation of Aplp2 1 0.14 0.25 0.09
78 INT262701 App Positive_regulation of Aplp2 1 0.12 0.25 0.09
79 INT214168 Msx1 Positive_regulation of Gene_expression of DST 1 0.00 0.13 0.09
80 INT356275 Gdnf Positive_regulation of Phosphorylation of Mapk1 1 0.05 0.21 0.09
81 INT270464 Binding of Shh and Smo 1 0.07 1.3 0.08
82 INT288374 Binding of MLANA and Msx1 1 0.09 0 0.08
83 INT290906 Shh Positive_regulation of Egfr 1 0.23 0 0.08
84 INT228501 Binding of AAVS1 and Fgfr1 1 0.01 0.57 0.07
85 INT303561 Binding of Fgf7 and Fgfr2 1 0.42 0.88 0.07
86 INT298349 HES3 Positive_regulation of Shh 1 0.12 0.14 0.07
87 INT303560 Binding of Fgfr2 and Fgf22 1 0.41 0.89 0.07
88 INT303562 Binding of Fgf10 and Fgfr2 1 0.40 0.88 0.07
89 INT290905 Gene_expression of Shh Positive_regulation of Gene_expression of Angpt1 1 0.14 0 0.06
90 INT311910 Acvrl1 Positive_regulation of Phosphorylation of Smad1 1 0.12 0.24 0.06
91 INT262652 Negative_regulation of Binding of HLA-DQA1 and Lmx1a 1 0.01 1.59 0.05
92 INT287877 WNT1 Positive_regulation of Localization of WISP1 1 0.03 0.56 0.05
93 INT287889 WNT1 Positive_regulation of KRT20 1 0.00 0.56 0.05
94 INT214146 Msx1 Positive_regulation of Gene_expression of Nucb2 1 0.05 0.19 0.05
95 INT250855 Binding of Fgfr2 and Fgf8 1 0.12 0.3 0.05
96 INT320439 Binding of Uchl5 and Psmb10 1 0.00 0 0.04
97 INT335017 Fgf23 Positive_regulation of Fgfr1 1 0.23 0.59 0.04
98 INT79985 Gdnf Negative_regulation of Negative_regulation of GAD1 1 0.04 0.46 0.04
99 INT213563 Binding of Ctnnd2 and Shh 1 0.27 0.09 0.04
100 INT79986 Gdnf Negative_regulation of Gene_expression of GAD1 1 0.03 0.46 0.04
101 INT270459 Binding of Shh and Gli1 1 0.02 0.65 0.04
102 INT311904 Smad2 Positive_regulation of Gene_expression of Smad1 1 0.13 0.44 0.03
103 INT312943 ANTXR1 Regulation of Gene_expression of Hes3 1 0.00 0.67 0.03
104 INT352014 Shh Positive_regulation of Gene_expression of Pax1 1 0.29 0.07 0.03
105 INT303558 Binding of Fgfr2 and Dysf 1 0.01 0.44 0.03
106 INT319219 Bmpr2 Positive_regulation of Smad1 1 0.18 0.29 0.03
107 INT311655 Shh Positive_regulation of Gene_expression of Fgf8 1 0.31 0.18 0.03
108 INT270462 Shh Positive_regulation of Ccnd1 1 0.10 0.6 0.03
109 INT213559 Binding of Egf and Shh 1 0.17 0.07 0.03
110 INT319217 Bmpr2 Positive_regulation of Gene_expression of Smad1 1 0.19 0.11 0.03
111 INT312942 ANTXR1 Regulation of Localization of Hes3 1 0.00 0.67 0.03
112 INT205611 Gm6668 Negative_regulation of Fgfr1 1 0.01 1.59 0
113 INT213549 Phox2b Regulation of Transcription of Phox2a 1 0.44 0.17 0
114 INT213552 Gene_expression of Phox2a Positive_regulation of Gene_expression of Phox2b 1 0.45 0.17 0
115 INT267117 Lmx1b Regulation of Col7a1 1 0.02 1.29 0
116 INT290910 Pkm2 Negative_regulation of Shh 1 0.07 0.06 0
117 INT205963 GLI1 Positive_regulation of Negative_regulation of SHH 1 0.22 0.58 0
118 INT314850 Shh Regulation of Atoh7 1 0.45 0.22 0
119 INT82387 Binding of Il2 and Barhl1 1 0.01 0 0
120 INT290908 Regulation of Shh Positive_regulation of Ntn1 1 0.12 0 0
121 INT264735 Binding of Hes1 and Mir199b 1 0.08 0.93 0
122 INT302321 Negative_regulation of Binding of Lrp6 and SOST 1 0.16 0.26 0
123 INT244846 Lbx1 Positive_regulation of Lmx1b 1 0.40 0 0
124 INT290911 Gene_expression of Shh Positive_regulation of Pkm2 1 0.07 0 0
125 INT264738 Mir199b Regulation of Gene_expression of Hes1 1 0.08 0.89 0
126 INT290904 Shh Positive_regulation of Prkcg 1 0.26 0.06 0
127 INT290900 Prkcg Regulation of Shh 1 0.23 0 0
128 INT183091 Binding of FGF2 and FGFR2 1 0.03 0.79 0
129 INT234985 Binding of Dsg3 and Pitx3 1 0.00 0.3 0
130 INT264736 Hes1 Regulation of Notch2 1 0.20 0.13 0
131 INT205960 Binding of PTCH1 and SHH 1 0.21 0.71 0
132 INT290944 Shh Positive_regulation of VEGFA 1 0.04 0.05 0
133 INT270461 Shh Regulation of Gene_expression of Ptch1 1 0.48 0.07 0
134 INT267115 Lmx1b Regulation of Gene_expression of Col4a1 1 0.09 1.37 0
135 INT329746 ENG Positive_regulation of SMAD1 1 0.15 0.44 0
136 INT197316 Hes1 Regulation of Atoh1 1 0.01 0.14 0
137 INT311656 Binding of Wnt1 and Spry1 1 0.30 0.39 0
138 INT213548 Neurog2 Regulation of Transcription of Phox2a 1 0.45 0.17 0
139 INT302320 Binding of Lrp6 and SOST 1 0.18 0.26 0
140 INT268521 Binding of WNT1 and MIR221 1 0.02 1.36 0
141 INT297855 Binding of Ndp and Wnt1 1 0.38 1.18 0
142 INT335887 Akt1 Regulation of Lrp6 1 0.06 0.15 0
143 INT205959 Binding of SHH and SMOX 1 0.12 0.72 0
144 INT312944 ANTXR1 Positive_regulation of Localization of Hes3 1 0.01 0.36 0
145 INT197304 Ahr Regulation of Hes1 1 0.06 0.17 0
146 INT335883 Binding of Lrp6 and Wnt5a 1 0.27 0.08 0
147 INT267116 Binding of Lmx1b and Nps 1 0.30 1.95 0
148 INT264731 Gene_expression of Hes1 Negative_regulation of Positive_regulation of Musd1 1 0.00 0.18 0
149 INT312939 Binding of Hes3 and Setd1a 1 0.01 0.66 0
150 INT270471 Shh Regulation of VEGFA 1 0.39 0.08 0
151 INT290898 Shh Positive_regulation of Nos2 1 0.46 0.05 0
152 INT202675 Fgf10 Positive_regulation of Fgfr2 1 0.45 0.07 0
153 INT267119 Lmx1b Regulation of Regulation of Col4a1 1 0.09 0.67 0
154 INT160761 Cma1 Regulation of Positive_regulation of ENG 1 0.01 0.07 0
155 INT270466 Ptch1 Regulation of Gene_expression of Shh 1 0.48 0.07 0
156 INT270460 Shh Positive_regulation of Gene_expression of Angpt1 1 0.04 0.08 0
157 INT267118 Lmx1b Regulation of Regulation of Col7a1 1 0.06 0.47 0
158 INT264729 Mir199b Regulation of Hes1 1 0.05 0.25 0
159 INT356271 Gdnf Positive_regulation of Positive_regulation of Mapk1 1 0.05 0.25 0
160 INT197310 Hes1 Regulation of Ascl1 1 0.01 0.14 0
161 INT270470 Shh Regulation of Gene_expression of VEGFA 1 0.39 0.15 0
162 INT264725 Binding of Hes1 and Notch1 1 0.03 0.84 0
163 INT213560 Phox2a Regulation of Transcription of Phox2b 1 0.44 0.17 0
164 INT290907 Shh Positive_regulation of Ntn1 1 0.32 0.05 0
165 INT264734 Mir199b Negative_regulation of Negative_regulation of Hes1 1 0.07 0.1 0
166 INT205977 Binding of SHH and Ptch1 1 0.31 0.71 0
167 INT270469 Shh Positive_regulation of VEGFA 1 0.29 0.12 0
168 INT270468 Shh Positive_regulation of Gene_expression of VEGFA 1 0.44 0.08 0
169 INT264739 Mir199b Negative_regulation of Gene_expression of Hes1 1 0.07 0.82 0
170 INT264737 Hes1 Regulation of Shh 1 0.19 0.13 0
171 INT183089 Positive_regulation of Binding of FGF2 and FGFR2 1 0.04 0.4 0
172 INT264733 Hes1 Regulation of Mir199b 1 0.05 0.43 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for midbrain development. They are ordered first by their pain relevance and then by number of times they were reported in midbrain development. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT74389 Gene_expression of Gdnf 131 0.78 58.52 57.06
2 INT77793 Positive_regulation of Gdnf 54 0.70 23.76 25.08
3 INT79981 Positive_regulation of Gene_expression of Gdnf 27 0.70 12.49 10.77
4 INT85844 Regulation of Gdnf 18 0.50 11.08 10.43
5 INT98111 Negative_regulation of Gdnf 12 0.59 10.85 9.29
6 INT77795 Localization of Gdnf 26 0.81 6.29 8.55
7 INT77794 Binding of Gdnf 15 0.48 8.38 8.22
8 INT92003 Positive_regulation of Transcription of Gdnf 10 0.66 5.54 7.84
9 INT87546 Transcription of Gdnf 15 0.71 7.49 7.76
10 INT92001 Regulation of Gene_expression of Gdnf 12 0.62 6.62 6.65
11 INT87548 Negative_regulation of Gene_expression of Gdnf 9 0.54 5.67 5.94
12 INT28160 Positive_regulation of Barhl1 7 0.64 1.55 5.46
13 INT123422 Gene_expression of Lmx1b 18 0.78 6.93 5.17
14 INT109391 Gene_expression of Fgfr1 7 0.56 1.78 3.67
15 INT131308 Gene_expression of Pitx3 11 0.74 3.69 3.5
16 INT28159 Negative_regulation of Barhl1 4 0.54 0 3.35
17 INT30861 Regulation of Barhl1 4 0.23 0.29 3.2
18 INT119218 Positive_regulation of Fgfr1 4 0.58 1.11 3.05
19 INT28162 Positive_regulation of Negative_regulation of Barhl1 1 0.43 0 3.02
20 INT32920 Gene_expression of Msx1 19 0.71 4.24 2.42
21 INT98650 Positive_regulation of Localization of Gdnf 4 0.68 0.94 2.27
22 INT144364 Negative_regulation of Lmx1b 5 0.45 3.35 2.12
23 INT141833 Gene_expression of WNT1 14 0.75 10.57 2.1
24 INT28161 Negative_regulation of Positive_regulation of Barhl1 1 0.54 0 2.06
25 INT180801 Regulation of Binding of Gdnf 1 0.20 1.31 2.03
26 INT29035 Negative_regulation of Wnt1 3 0.41 1.47 2
27 INT144973 Gene_expression of Shh 9 0.77 4.32 1.96
28 INT208561 Gene_expression of Shh 51 0.78 9.57 1.77
29 INT86558 Negative_regulation of Cma1 5 0.45 3.11 1.59
30 INT98651 Regulation of Positive_regulation of Gdnf 3 0.44 0.97 1.58
31 INT87547 Negative_regulation of Transcription of Gdnf 1 0.58 1.24 1.4
32 INT98653 Negative_regulation of Localization of Gdnf 1 0.57 0.31 1.35
33 INT353966 Negative_regulation of Gene_expression of Lmx1b 1 0.43 0.16 1.31
34 INT138726 Positive_regulation of Gene_expression of Msx1 5 0.53 1.73 1.2
35 INT141834 Negative_regulation of Gene_expression of WNT1 3 0.57 1.31 1.2
36 INT108519 Binding of Lrp6 8 0.44 1.47 1.19
37 INT253191 Positive_regulation of Gene_expression of Shh 2 0.66 2.57 1.14
38 INT49486 Gene_expression of Cma1 6 0.52 4.17 1.13
39 INT33375 Gene_expression of Barhl1 2 0.25 0.59 1.12
40 INT76890 Gene_expression of FGFR2 42 0.65 13.91 1.08
41 INT180795 Positive_regulation of Positive_regulation of Gdnf 2 0.29 0.1 1.07
42 INT165530 Positive_regulation of Shh 4 0.69 1.21 1.05
43 INT108985 Negative_regulation of Regulation of Gdnf 1 0.43 1.11 1.04
44 INT183182 Negative_regulation of FGFR2 2 0.29 1.25 0.84
45 INT225013 Gene_expression of Cxcl5 1 0.33 0.15 0.84
46 INT141835 Negative_regulation of WNT1 2 0.41 1.02 0.83
47 INT202628 Gene_expression of Wnt1 20 0.67 9.2 0.82
48 INT33376 Positive_regulation of Positive_regulation of Barhl1 1 0.06 0.53 0.77
49 INT121947 Negative_regulation of Positive_regulation of Gdnf 1 0.20 0.07 0.76
50 INT33378 Regulation of Gene_expression of Barhl1 1 0.04 0.52 0.74
51 INT95617 Regulation of Msx1 2 0.56 1.05 0.73
52 INT166537 Localization of Fgfr1 5 0.40 2.69 0.69
53 INT173508 Negative_regulation of Fgfr1 4 0.55 5.08 0.66
54 INT75043 Binding of Msx1 6 0.35 2.36 0.65
55 INT264709 Gene_expression of Hes1 24 0.76 7.04 0.63
56 INT158136 Binding of FGFR2 9 0.26 4.5 0.63
57 INT298346 Gene_expression of HES3 1 0.53 1.17 0.63
58 INT146775 Phosphorylation of Fgfr1 1 0.53 0.8 0.62
59 INT267114 Positive_regulation of Lmx1b 2 0.50 0.96 0.6
60 INT25631 Binding of Barhl1 1 0.12 0 0.58
61 INT150949 Gene_expression of Fgfr1 6 0.63 5.71 0.57
62 INT32921 Positive_regulation of Msx1 4 0.47 0.99 0.57
63 INT98112 Positive_regulation of Negative_regulation of Gdnf 1 0.05 0.44 0.57
64 INT216363 Gene_expression of OTX2 4 0.54 0.32 0.55
65 INT312933 Localization of Hes3 1 0.63 7.94 0.53
66 INT146776 Transcription of Fgfr1 1 0.45 0.67 0.49
67 INT146777 Regulation of Transcription of Fgfr1 1 0.23 0.67 0.49
68 INT146778 Negative_regulation of Fgfr2 1 0.32 0.66 0.48
69 INT206484 Localization of Shh 2 0.75 1.14 0.46
70 INT127069 Regulation of Localization of Gdnf 1 0.34 0.46 0.46
71 INT232798 Positive_regulation of Gene_expression of Shh 7 0.70 1.49 0.44
72 INT226784 Positive_regulation of Cma1 3 0.32 3.46 0.44
73 INT267113 Regulation of Gene_expression of Lmx1b 2 0.62 1.36 0.44
74 INT228057 Positive_regulation of WNT1 1 0.49 1.8 0.44
75 INT188371 Regulation of Localization of Fgfr1 1 0.10 1.02 0.43
76 INT247307 Negative_regulation of Msx1 3 0.22 0.11 0.42
77 INT202626 Negative_regulation of Fgfr2 2 0.41 2.48 0.42
78 INT285501 Gene_expression of Smad1 6 0.42 3.09 0.41
79 INT148433 Negative_regulation of Binding of Gdnf 1 0.41 1.14 0.4
80 INT311882 Negative_regulation of Smad1 1 0.25 0.99 0.39
81 INT208559 Negative_regulation of Gene_expression of Shh 8 0.43 1.58 0.38
82 INT123421 Binding of Lmx1b 1 0.36 0.54 0.35
83 INT216379 Positive_regulation of Gene_expression of WNT1 5 0.30 3.1 0.34
84 INT298347 Positive_regulation of Gene_expression of HES3 1 0.34 0.72 0.34
85 INT131311 Negative_regulation of Pitx3 1 0.56 0.5 0.34
86 INT225007 Positive_regulation of Cxcl5 1 0.25 0.12 0.33
87 INT150948 Positive_regulation of Gene_expression of Fgfr1 3 0.15 3.19 0.32
88 INT160760 Regulation of Cma1 1 0.21 0.19 0.31
89 INT180696 Positive_regulation of Gene_expression of Fgfr1 1 0.32 0.08 0.28
90 INT335875 Regulation of Lrp6 1 0.57 0.43 0.27
91 INT328583 Transcription of Pitx3 1 0.21 0.49 0.27
92 INT214128 Negative_regulation of Gene_expression of Msx1 3 0.53 1.25 0.26
93 INT232795 Positive_regulation of Shh 2 0.70 3.68 0.26
94 INT176080 Gene_expression of Fgfr2 4 0.68 2.34 0.24
95 INT285474 Negative_regulation of Gene_expression of Fgfr1 2 0.40 2.15 0.24
96 INT27461 Gene_expression of Lmx1a 2 0.52 0.18 0.23
97 INT328588 Negative_regulation of Gene_expression of Pitx3 1 0.12 0 0.23
98 INT223739 Binding of Fgfr2 3 0.30 0.94 0.22
99 INT353973 Localization of Lmx1b 1 0.75 0.3 0.22
100 INT183062 Gene_expression of SHH 12 0.65 5.28 0.21
101 INT213524 Transcription of Phox2a 2 0.64 0.29 0.21
102 INT188373 Positive_regulation of Localization of Fgfr1 1 0.19 1.09 0.21
103 INT173515 Negative_regulation of Transcription of Fgfr1 1 0.06 0.92 0.21
104 INT303539 Binding of Fgfr1 3 0.45 0.96 0.2
105 INT134477 Negative_regulation of SHH 2 0.37 1.13 0.2
106 INT312932 Gene_expression of Hes3 1 0.61 3.2 0.2
107 INT173503 Transcription of Fgfr1 1 0.08 0.92 0.2
108 INT311891 Phosphorylation of Smad1 4 0.51 1.34 0.18
109 INT89242 Negative_regulation of Localization of Barhl1 1 0.01 0 0.18
110 INT264701 Negative_regulation of Gene_expression of Hes1 1 0.42 0.73 0.18
111 INT89241 Localization of Barhl1 1 0.03 0 0.18
112 INT328585 Regulation of Pitx3 1 0.13 0.16 0.18
113 INT353965 Negative_regulation of Gene_expression of Wnt1 1 0.41 0 0.18
114 INT262634 Binding of Lmx1a 1 0.02 0.74 0.17
115 INT335861 Localization of Lrp6 1 0.69 0.54 0.17
116 INT225011 Positive_regulation of Gene_expression of Cxcl5 1 0.25 0 0.17
117 INT232799 Regulation of Gene_expression of Shh 3 0.27 1.04 0.16
118 INT267112 Regulation of Lmx1b 3 0.61 2.21 0.16
119 INT262690 Gene_expression of Aplp2 3 0.56 1.14 0.16
120 INT253177 Negative_regulation of Gene_expression of Shh 2 0.55 0.63 0.16
121 INT217569 Binding of Wnt1 2 0.36 1.07 0.15
122 INT310174 Positive_regulation of Smad1 9 0.45 2.16 0.14
123 INT253190 Localization of Shh 2 0.77 1.06 0.13
124 INT214127 Localization of Msx1 1 0.06 0.21 0.13
125 INT99718 Positive_regulation of Gene_expression of FGFR2 9 0.49 4.47 0.12
126 INT253183 Negative_regulation of Shh 8 0.55 2.13 0.12
127 INT312930 Positive_regulation of Gene_expression of Hes3 1 0.54 0.22 0.12
128 INT312929 Regulation of Phosphorylation of Hes3 1 0.21 0.36 0.11
129 INT312935 Regulation of Hes3 1 0.35 0.59 0.11
130 INT312938 Phosphorylation of Hes3 1 0.49 0.36 0.11
131 INT312926 Positive_regulation of Hes3 1 0.54 0.35 0.11
132 INT312936 Regulation of Positive_regulation of Hes3 1 0.48 0.36 0.11
133 INT353970 Transcription of Lmx1b 1 0.72 0 0.1
134 INT188374 Negative_regulation of Fgfr1 1 0.22 0.68 0.1
135 INT82834 Positive_regulation of Gene_expression of Cma1 2 0.31 1.52 0.09
136 INT213513 Gene_expression of Phox2a 1 0.72 0.51 0.09
137 INT266241 Regulation of Wnt1 1 0.26 0.59 0.09
138 INT312937 Positive_regulation of Localization of Hes3 1 0.54 0.55 0.09
139 INT270442 Transcription of Shh 1 0.53 0.25 0.09
140 INT213515 Binding of Shh 8 0.37 1.92 0.08
141 INT298343 Binding of HES3 1 0.33 0.33 0.08
142 INT250851 Binding of Fgfr1 1 0.10 0.19 0.08
143 INT262676 Positive_regulation of Gene_expression of Aplp2 1 0.29 0.24 0.08
144 INT312927 Negative_regulation of Hes3 1 0.29 0.07 0.08
145 INT270453 Regulation of Shh 1 0.27 0.83 0.08
146 INT205973 Binding of SHH 3 0.35 1.03 0.07
147 INT256862 Regulation of Shh 1 0.25 0 0.07
148 INT193831 Localization of Aplp2 2 0.42 1.85 0.06
149 INT298344 Negative_regulation of Gene_expression of HES3 1 0.40 0 0.06
150 INT298339 Negative_regulation of HES3 1 0.29 0 0.06
151 INT312934 Regulation of Gene_expression of Hes3 1 0.48 0.76 0.06
152 INT303546 Binding of Fgfr2 1 0.46 0.74 0.06
153 INT193852 Positive_regulation of Localization of Aplp2 1 0.23 0.81 0.06
154 INT188372 Negative_regulation of Localization of Fgfr1 1 0.22 0.66 0.06
155 INT335865 Positive_regulation of Phosphorylation of Lrp6 1 0.64 0.46 0.05
156 INT335862 Phosphorylation of Lrp6 1 0.76 0.37 0.05
157 INT270445 Positive_regulation of Localization of Shh 1 0.44 0.13 0.05
158 INT213536 Negative_regulation of Gene_expression of Phox2a 1 0.39 0.1 0.05
159 INT298342 Positive_regulation of HES3 1 0.32 0.13 0.05
160 INT304937 Transcription of Wnt1 1 0.22 0.65 0.05
161 INT181793 Positive_regulation of SHH 3 0.67 2.59 0.04
162 INT188125 Binding of Aplp2 2 0.22 0.64 0.04
163 INT311890 Binding of Smad1 2 0.23 0.46 0.04
164 INT287956 Regulation of WNT1 2 0.26 2.38 0.04
165 INT208560 Negative_regulation of Shh 2 0.59 2.22 0.04
166 INT320365 Binding of Uchl5 1 0.02 0 0.04
167 INT213521 Positive_regulation of Gene_expression of Phox2a 1 0.64 0.24 0.04
168 INT311648 Regulation of Gene_expression of Wnt1 1 0.39 0.09 0.04
169 INT287936 Regulation of Gene_expression of WNT1 1 0.20 1.06 0.04
170 INT264717 Negative_regulation of Hes1 7 0.42 0.77 0.03
171 INT264704 Regulation of Hes1 4 0.44 1.03 0.03
172 INT303538 Positive_regulation of Fgfr1 3 0.65 0.92 0.03
173 INT303544 Positive_regulation of Negative_regulation of Fgfr1 1 0.47 1.07 0.03
174 INT303525 Localization of Fgfr2 1 0.72 0.28 0.03
175 INT253187 Negative_regulation of Transcription of Shh 1 0.41 0.55 0.03
176 INT303547 Positive_regulation of Negative_regulation of Fgfr2 1 0.48 1.07 0.03
177 INT253181 Transcription of Shh 1 0.68 0.54 0.03
178 INT298340 Transcription of HES3 1 0.49 0.06 0.03
179 INT303536 Localization of Fgfr1 1 0.70 0.28 0.03
180 INT213518 Regulation of Gene_expression of Phox2a 1 0.57 0.35 0.03
181 INT311888 Negative_regulation of Phosphorylation of Smad1 1 0.25 0.48 0.03
182 INT298341 Positive_regulation of Transcription of HES3 1 0.47 0.06 0.03
183 INT264702 Positive_regulation of Gene_expression of Hes1 1 0.68 1.39 0.03
184 INT207729 Regulation of FGFR2 4 0.22 2.35 0
185 INT238985 Positive_regulation of FGFR2 3 0.49 1.19 0
186 INT202633 Positive_regulation of Gene_expression of Wnt1 3 0.43 0.85 0
187 INT99716 Transcription of FGFR2 2 0.34 0.22 0
188 INT264719 Regulation of Gene_expression of Hes1 2 0.28 0.12 0
189 INT305351 Positive_regulation of Regulation of FGFR2 2 0.37 0.97 0
190 INT99715 Regulation of Gene_expression of FGFR2 2 0.22 0.19 0
191 INT234879 Binding of Pitx3 2 0.11 1.21 0
192 INT303555 Negative_regulation of Gene_expression of FGFR2 2 0.41 0.31 0
193 INT264708 Transcription of Hes1 1 0.67 0.83 0
194 INT310246 Positive_regulation of Positive_regulation of Fgfr1 1 0.31 0 0
195 INT202623 Negative_regulation of Gene_expression of Fgfr2 1 0.32 0 0
196 INT319036 Gene_expression of Fgfr2 1 0.48 0.08 0
197 INT329771 Positive_regulation of SMAD1 1 0.36 2.3 0
198 INT329780 Negative_regulation of Positive_regulation of SMAD1 1 0.22 0.51 0
199 INT335872 Positive_regulation of Gene_expression of Lrp6 1 0.46 0.18 0
200 INT328584 Positive_regulation of Gene_expression of Pitx3 1 0.13 0.06 0
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