GO:0030911

From wiki-pain
Jump to: navigation, search
Name TPR domain binding
Categary Function
Go Slim No
Go Link GO:0030911
Unique Molecular Interactions 82
Total Molecular Interactions 105
Total Single Events 617
Pain Genes Associated 9

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for TPR domain binding. They are ordered first by their pain relevance and then by number of times they were reported for TPR domain binding. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT14197 Pde2a Positive_regulation of Localization of Gh1 2 0.04 0 1.08
2 INT258798 Binding of NR3C1 and HSP90AA1 1 0.01 1.09 0.78
3 INT165844 Binding of ATF4 and HSP90AB1 1 0.15 0.34 0.61
4 INT275087 Pde2a Negative_regulation of stm 1 0.01 0.51 0.42
5 INT275104 Pde2a Negative_regulation of RTP3 1 0.00 0.51 0.42
6 INT188521 Binding of Hsp90aa1 and Ptges3 1 0.02 0.61 0.33
7 INT126227 Hsp90aa1 Positive_regulation of Nos1 1 0.03 0.73 0.25
8 INT243640 Binding of Twist1 and Stub1 1 0.08 0.34 0.24
9 INT235125 PDE2A Negative_regulation of Twist1 1 0.00 0.99 0.24
10 INT324822 Binding of Cd24a and Hsp90aa1 1 0.10 0.71 0.19
11 INT209645 AR Regulation of STUB1 1 0.04 0.93 0.13
12 INT135941 Positive_regulation of PDE2A Positive_regulation of Gene_expression of PRKG1 1 0.13 0.8 0.13
13 INT135943 Positive_regulation of PRKG1 Regulation of PDE2A 1 0.08 0.73 0.1
14 INT257217 Binding of Pde2a and Pde5a 1 0.03 0 0.1
15 INT230857 Negative_regulation of Binding of HSP90AA1 and NOS1 1 0.05 1.18 0.09
16 INT230856 Binding of HSP90AA1 and NOS1 1 0.04 1.17 0.09
17 INT148096 Vasp Regulation of Pde2a 1 0.00 0.23 0.08
18 INT98269 PDE2A Positive_regulation of PRKG1 1 0.07 0.57 0.08
19 INT98270 Positive_regulation of PDE2A Positive_regulation of PRKG1 1 0.07 0.57 0.08
20 INT298258 Binding of Runx3 and Stub1 1 0.11 0.18 0.06
21 INT293494 Sfpi1 Regulation of Negative_regulation of Hsp90aa1 1 0.04 0.23 0.05
22 INT350434 Negative_regulation of HSP90AA1 Positive_regulation of Gene_expression of ATF3 1 0.32 2.44 0.04
23 INT213815 Binding of Tfeb and Stub1 1 0.13 0.09 0.04
24 INT234196 ERBB2 Positive_regulation of Negative_regulation of HSP90AA1 1 0.19 0.79 0.03
25 INT325600 Nppa Positive_regulation of Pde2a 1 0.11 0.16 0.03
26 INT234195 HSP90AA1 Regulation of AKT1 1 0.14 0.65 0.03
27 INT350432 HSP90AA1 Positive_regulation of Gene_expression of ATF3 1 0.32 1.27 0
28 INT292679 GOPC Positive_regulation of HSP90AA1 1 0.01 0.1 0
29 INT308425 Binding of Pde2a and Aip 1 0.04 1.37 0
30 INT325602 Binding of Ang and Pde2a 1 0.07 0.15 0
31 INT313117 Binding of Stub1 and Carf 1 0.10 0 0
32 INT293492 Hsp90aa1 Regulation of Gene_expression of Sfpi1 1 0.04 0.1 0
33 INT340914 Binding of Hsp90aa1 and Fkbp6 1 0.12 0.26 0
34 INT186239 Binding of ROS1 and Positive_regulation of PDE2A 1 0.00 0 0
35 INT350430 Negative_regulation of HSP90AA1 Positive_regulation of ATF3 1 0.32 3.11 0
36 INT293493 Hsp90aa1 Regulation of Gene_expression of Erbb2 1 0.38 0.1 0
37 INT186241 Gene_expression of ROS1 Positive_regulation of PDE2A 1 0.00 0 0
38 INT325603 Pde2a Regulation of Rgs2 1 0.03 0 0
39 INT234214 Binding of HSP90AA1 and Tpt1 1 0.04 0.42 0
40 INT256701 Binding of Hsp90aa1 and Hsp90b1 1 0.12 0.34 0
41 INT282743 Hsp90aa1 Positive_regulation of Kit 1 0.22 0.54 0
42 INT340913 Fkbp6 Negative_regulation of Binding of Hsp90aa1 1 0.14 0.26 0
43 INT317307 Binding of Hsp90aa1 and Pink1 1 0.12 0.56 0
44 INT350503 Binding of HSP90AA1 and JAK2 1 0.06 1.39 0
45 INT325613 Pls1 Regulation of Pde2a 1 0.00 0 0
46 INT243635 Positive_regulation of Binding of Nfatc2 and Stub1 1 0.09 0 0
47 INT100265 Hsp90aa1 Regulation of Positive_regulation of Esrrb 1 0.10 0.1 0
48 INT340915 Binding of Hsp90aa1 and Ptplad1 1 0.12 0.17 0
49 INT265383 Hsp90aa1 Negative_regulation of HDAC9 1 0.06 0.7 0
50 INT325593 Pde2a Positive_regulation of Negative_regulation of Nppa 1 0.11 0 0
51 INT66168 Pde2a Negative_regulation of Adra2a 1 0.04 0 0
52 INT325612 Rgs2 Regulation of Pde2a 1 0.10 0 0
53 INT325609 Pde2a Positive_regulation of Gene_expression of Rgs2 1 0.12 0 0
54 INT243628 Binding of Nfatc2 and Stub1 1 0.06 0 0
55 INT311064 HSP90AA1 Positive_regulation of Positive_regulation of HSF1 1 0.20 0.17 0
56 INT350431 HSP90AA1 Positive_regulation of ATF3 1 0.47 1.55 0
57 INT311061 HSP90AA1 Positive_regulation of HSF1 1 0.20 0.17 0
58 INT350505 Negative_regulation of Binding of HSP90AA1 and JAK2 1 0.07 1.5 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for TPR domain binding. They are ordered first by their pain relevance and then by number of times they were reported in TPR domain binding. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT188852 Gene_expression of Pde2a 13 0.19 6.44 5.35
2 INT75815 Positive_regulation of PDE2A 10 0.40 5.1 3.15
3 INT30172 Positive_regulation of Pde2a 3 0.39 0.55 2.77
4 INT77656 Gene_expression of Hsp90aa1 12 0.78 24.27 1.81
5 INT64530 Negative_regulation of Positive_regulation of Pde2a 1 0.36 0 1.81
6 INT12781 Regulation of Pde2a 4 0.23 1.14 1.69
7 INT64529 Localization of Pde2a 1 0.59 0 1.63
8 INT1580 Negative_regulation of Pde2a 7 0.52 3.26 1.59
9 INT188855 Positive_regulation of Gene_expression of Pde2a 5 0.12 1.97 1.53
10 INT125320 Negative_regulation of HSP90AA1 20 0.45 23.93 1.42
11 INT88855 Negative_regulation of Hsp90aa1 4 0.54 2.16 1.34
12 INT14195 Localization of Pde2a 4 0.16 0.34 1.33
13 INT133898 Binding of HSP90AA1 17 0.30 8.83 1.12
14 INT46734 Positive_regulation of Stub1 6 0.16 1.44 1.09
15 INT7834 Gene_expression of Pde2a 5 0.51 1.9 1.01
16 INT100612 Positive_regulation of Hsp90aa1 4 0.64 5.3 1.01
17 INT188851 Regulation of Gene_expression of Pde2a 1 0.04 0.75 0.94
18 INT88861 Positive_regulation of Gene_expression of Hsp90aa1 4 0.64 7.43 0.9
19 INT89776 Positive_regulation of Pde2a 2 0.47 2.84 0.81
20 INT98275 Negative_regulation of PDE2A 4 0.17 3.96 0.79
21 INT183161 Regulation of Pde2a 2 0.05 0.5 0.67
22 INT192235 Binding of Hsp90aa1 6 0.19 1.46 0.6
23 INT88859 Transcription of Hsp90aa1 1 0.58 1.51 0.6
24 INT166086 Binding of Hsp90aa1 1 0.28 0.08 0.6
25 INT165847 Positive_regulation of HSP90AB1 1 0.60 0.31 0.6
26 INT88857 Negative_regulation of Transcription of Hsp90aa1 1 0.36 1.52 0.6
27 INT196939 Gene_expression of Stub1 10 0.18 1.67 0.59
28 INT165846 Regulation of HSP90AA1 4 0.27 2.19 0.58
29 INT127480 Negative_regulation of Hsp90aa1 20 0.57 10.67 0.56
30 INT165849 Protein_catabolism of HSP90AB1 1 0.56 0.28 0.56
31 INT75814 Regulation of Positive_regulation of PDE2A 1 0.23 0.26 0.56
32 INT89258 Localization of STUB1 3 0.14 0.67 0.49
33 INT209013 Regulation of Stub1 1 0.06 0.29 0.46
34 INT73976 Gene_expression of Hsp90aa1 18 0.75 7.92 0.45
35 INT162903 Localization of PDE2A 2 0.61 0.89 0.45
36 INT88856 Negative_regulation of Gene_expression of Hsp90aa1 2 0.39 2.31 0.45
37 INT216759 Binding of PDE2A 1 0.00 0.08 0.44
38 INT235122 Negative_regulation of Positive_regulation of PDE2A 1 0.01 0.72 0.35
39 INT235113 Positive_regulation of Negative_regulation of PDE2A 1 0.01 0.72 0.35
40 INT135945 Positive_regulation of Positive_regulation of PDE2A 2 0.12 0.78 0.34
41 INT293480 Protein_catabolism of Hsp90aa1 2 0.65 0.82 0.32
42 INT144854 Gene_expression of STUB1 10 0.13 2.03 0.31
43 INT77654 Regulation of Gene_expression of Hsp90aa1 4 0.62 2.41 0.28
44 INT129812 Gene_expression of HSP90AB1 1 0.75 0.72 0.27
45 INT144855 Positive_regulation of STUB1 3 0.08 0.59 0.26
46 INT321170 Positive_regulation of Protein_catabolism of Hsp90aa1 1 0.29 0.2 0.25
47 INT304603 Positive_regulation of HSP90AA1 1 0.26 7.01 0.24
48 INT73178 Positive_regulation of Hsp90aa1 4 0.45 0.7 0.21
49 INT203471 Localization of Stub1 1 0.23 0.5 0.21
50 INT98276 Regulation of PDE2A 2 0.07 1.54 0.17
51 INT102355 Gene_expression of HSP90AA1 8 0.51 5.2 0.12
52 INT84749 Gene_expression of PDE2A 3 0.73 0.84 0.12
53 INT135946 Positive_regulation of Gene_expression of PDE2A 1 0.12 0.77 0.12
54 INT135944 Regulation of Regulation of PDE2A 1 0.07 0.73 0.1
55 INT184167 Binding of STUB1 5 0.07 0.72 0.08
56 INT243617 Binding of Stub1 3 0.09 0.16 0.08
57 INT192236 Positive_regulation of Binding of Hsp90aa1 2 0.24 0.59 0.08
58 INT80630 Protein_catabolism of PDE2A 2 0.19 0.91 0.08
59 INT111440 Negative_regulation of Gene_expression of Pde2a 1 0.20 1.14 0.07
60 INT234206 Localization of HSP90AA1 4 0.68 2.89 0.06
61 INT234211 Regulation of Negative_regulation of HSP90AA1 2 0.27 1.13 0.06
62 INT234207 Negative_regulation of Binding of HSP90AA1 2 0.26 0.84 0.05
63 INT183439 Protein_catabolism of Pde2a 1 0.14 0.84 0.05
64 INT183425 Negative_regulation of Protein_catabolism of Pde2a 1 0.09 0.84 0.05
65 INT183433 Regulation of Localization of Pde2a 1 0.09 0.34 0.04
66 INT302546 Regulation of Gene_expression of Hsp90aa1 1 0.21 0.88 0.04
67 INT328544 Localization of Hsp90aa1 1 0.10 0.17 0.03
68 INT234208 Negative_regulation of Localization of HSP90AA1 1 0.26 0.59 0.03
69 INT182999 Negative_regulation of Gene_expression of STUB1 1 0.08 0.31 0.03
70 INT222086 Positive_regulation of Gene_expression of Hsp90aa1 1 0.24 0 0.03
71 INT234209 Protein_catabolism of HSP90AA1 5 0.54 2.67 0
72 INT234212 Positive_regulation of Gene_expression of HSP90AA1 3 0.41 1.36 0
73 INT200277 Positive_regulation of Gene_expression of Stub1 2 0.06 0 0
74 INT196230 Regulation of STUB1 2 0.05 0.8 0
75 INT73983 Transcription of Hsp90aa1 2 0.43 0.08 0
76 INT234213 Regulation of Binding of HSP90AA1 1 0.27 0.21 0
77 INT209699 Negative_regulation of STUB1 1 0.07 0.41 0
78 INT350514 Positive_regulation of Phosphorylation of HSP90AA1 1 0.10 0.74 0
79 INT222091 Regulation of Transcription of Hsp90aa1 1 0.09 0 0
80 INT162918 Transcription of PDE2A 1 0.65 0 0
81 INT311072 Positive_regulation of Localization of HSP90AA1 1 0.22 0.53 0
82 INT293485 Regulation of Hsp90aa1 1 0.33 0.37 0
83 INT342089 Regulation of Gene_expression of Stub1 1 0.02 0.16 0
84 INT350518 Phosphorylation of HSP90AA1 1 0.16 0.72 0
85 INT162914 Regulation of Localization of PDE2A 1 0.37 0 0
86 INT293680 Positive_regulation of Localization of HSP90AB1 1 0.45 0 0
87 INT293483 Positive_regulation of Regulation of Hsp90aa1 1 0.37 0.37 0
88 INT162916 Negative_regulation of Transcription of PDE2A 1 0.40 0 0
89 INT313091 Negative_regulation of Stub1 1 0.07 0.25 0
90 INT293675 Localization of HSP90AB1 1 0.68 0 0
91 INT183430 Binding of Pde2a 1 0.07 0 0
92 INT325558 Negative_regulation of Gene_expression of Pde2a 1 0.11 0.38 0
93 INT293488 Positive_regulation of Negative_regulation of Hsp90aa1 1 0.37 0.21 0
94 INT234205 Negative_regulation of Negative_regulation of HSP90AA1 1 0.26 0.28 0
95 INT293486 Negative_regulation of Protein_catabolism of Hsp90aa1 1 0.31 0.41 0
96 INT350445 Positive_regulation of Negative_regulation of HSP90AA1 1 0.30 3.25 0
97 INT293490 Negative_regulation of Gene_expression of Hsp90aa1 1 0.31 0.15 0
98 INT222079 Positive_regulation of Transcription of Hsp90aa1 1 0.16 0 0
99 INT80629 Negative_regulation of Protein_catabolism of PDE2A 1 0.12 0.18 0
Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox