GO:0030916

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Name otic vesicle formation
Categary Process
Go Slim No
Go Link GO:0030916
Unique Molecular Interactions 40
Total Molecular Interactions 61
Total Single Events 362
Pain Genes Associated 10

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for otic vesicle formation. They are ordered first by their pain relevance and then by number of times they were reported for otic vesicle formation. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT250867 Fgf8 Positive_regulation of Protein_catabolism of Ecm1 1 0.06 4.35 2.14
2 INT250868 Fgf8 Positive_regulation of Gene_expression of Mmp3 1 0.15 1.73 0.93
3 INT183176 Binding of FGFR2 and NUDT6 1 0.05 1.07 0.84
4 INT250861 Fgf8 Positive_regulation of Gene_expression of Ptger2 1 0.04 1.51 0.84
5 INT250852 Fgf8 Negative_regulation of Gene_expression of Ecm1 1 0.04 1.1 0.54
6 INT250870 Fgf8 Positive_regulation of Ecm1 1 0.04 0.79 0.38
7 INT250856 Fgf8 Positive_regulation of Localization of Mmp3 1 0.11 0.51 0.3
8 INT250864 Fgf8 Positive_regulation of Positive_regulation of Ptger2 1 0.03 0.55 0.28
9 INT250854 Fgf8 Positive_regulation of Positive_regulation of Mmp3 1 0.11 0.55 0.28
10 INT250873 Fgf8 Positive_regulation of GAG 1 0.55 0.48 0.23
11 INT250863 Fgf8 Positive_regulation of Ptger2 1 0.03 0.19 0.14
12 INT250866 Binding of Fgfr4 and Fgf8 1 0.12 0.35 0.11
13 INT250860 Fgf8 Regulation of Localization of Ptger2 1 0.02 0.13 0.1
14 INT250862 Fgf8 Regulation of Localization of Mmp3 1 0.13 0.13 0.1
15 INT250859 Fgf8 Negative_regulation of Gene_expression of Mmp3 1 0.09 0.12 0.09
16 INT250872 Fgf8 Positive_regulation of Mmp3 1 0.11 0.12 0.09
17 INT303561 Binding of Fgf7 and Fgfr2 1 0.42 0.88 0.07
18 INT303560 Binding of Fgfr2 and Fgf22 1 0.41 0.89 0.07
19 INT303562 Binding of Fgf10 and Fgfr2 1 0.40 0.88 0.07
20 INT250865 Binding of Fgf8 and Fgfr3 1 0.18 0.3 0.05
21 INT250855 Binding of Fgfr2 and Fgf8 1 0.12 0.3 0.05
22 INT322891 Sox9 Regulation of Transcription of Col2a1 1 0.10 0.12 0.04
23 INT184208 IL1B Negative_regulation of SOX9 1 0.32 0 0.03
24 INT303558 Binding of Fgfr2 and Dysf 1 0.01 0.44 0.03
25 INT303563 Binding of Fgf10 and Dysf 1 0.00 0.44 0.03
26 INT311655 Shh Positive_regulation of Gene_expression of Fgf8 1 0.31 0.18 0.03
27 INT210260 Sox9 Negative_regulation of Cdx2 1 0.20 0 0.03
28 INT320029 Gene_expression of SOX9 Positive_regulation of Gene_expression of COL7A1 1 0.03 0 0
29 INT245726 SOX9 Regulation of SGCG 1 0.00 0.29 0
30 INT333879 Shc1 Positive_regulation of SOX9 1 0.01 0 0
31 INT225570 Ncoa6 Regulation of Sox9 1 0.16 0.72 0
32 INT183091 Binding of FGF2 and FGFR2 1 0.03 0.79 0
33 INT303342 Binding of NPAT and TCAP 1 0.40 0 0
34 INT303404 Binding of TCAP and Jag1 1 0.39 0 0
35 INT202675 Fgf10 Positive_regulation of Fgfr2 1 0.45 0.07 0
36 INT245735 SOX9 Regulation of COL5A2 1 0.07 0.29 0
37 INT183089 Positive_regulation of Binding of FGF2 and FGFR2 1 0.04 0.4 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for otic vesicle formation. They are ordered first by their pain relevance and then by number of times they were reported in otic vesicle formation. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT250832 Gene_expression of Fgf8 1 0.77 13.36 6.2
2 INT250841 Positive_regulation of Gene_expression of Fgf8 1 0.69 3.8 1.72
3 INT250850 Negative_regulation of Gene_expression of Fgf8 1 0.42 2.79 1.33
4 INT134663 Gene_expression of SOX9 40 0.75 9.07 1.2
5 INT250840 Negative_regulation of Fgf8 1 0.43 1.92 1.11
6 INT76890 Gene_expression of FGFR2 42 0.65 13.91 1.08
7 INT277461 Positive_regulation of Gene_expression of Fgf8 1 0.24 0.47 1.05
8 INT166715 Gene_expression of Sox9 16 0.65 6.39 0.92
9 INT183182 Negative_regulation of FGFR2 2 0.29 1.25 0.84
10 INT145306 Gene_expression of Sox9 5 0.54 2.47 0.8
11 INT158136 Binding of FGFR2 9 0.26 4.5 0.63
12 INT39728 Regulation of TCAP 1 0.00 0 0.61
13 INT184222 Negative_regulation of SOX9 7 0.41 2.68 0.58
14 INT157103 Transcription of SOX9 6 0.59 1.2 0.58
15 INT296583 Gene_expression of Fgf10 3 0.59 2.64 0.57
16 INT296594 Regulation of Fgf10 1 0.15 1.53 0.56
17 INT157104 Positive_regulation of SOX9 6 0.66 1.66 0.52
18 INT157105 Positive_regulation of Transcription of SOX9 4 0.58 0.88 0.51
19 INT250845 Protein_catabolism of Fgf8 1 0.98 1.64 0.48
20 INT146778 Negative_regulation of Fgfr2 1 0.32 0.66 0.48
21 INT268007 Gene_expression of Fgf8 8 0.72 1.38 0.47
22 INT145304 Regulation of Gene_expression of Sox9 1 0.43 1.04 0.46
23 INT277465 Regulation of Gene_expression of Fgf8 2 0.25 0.43 0.43
24 INT202626 Negative_regulation of Fgfr2 2 0.41 2.48 0.42
25 INT250826 Transcription of Fgf8 1 0.71 0.71 0.34
26 INT176080 Gene_expression of Fgfr2 4 0.68 2.34 0.24
27 INT250836 Binding of Fgf8 3 0.35 0.66 0.24
28 INT223739 Binding of Fgfr2 3 0.30 0.94 0.22
29 INT145303 Regulation of Sox9 2 0.28 0.71 0.22
30 INT245763 Regulation of SOX9 4 0.43 1.68 0.21
31 INT250833 Localization of Fgf8 1 0.74 0.46 0.21
32 INT250842 Negative_regulation of Binding of Fgf8 1 0.43 0.33 0.21
33 INT134662 Positive_regulation of Gene_expression of SOX9 9 0.48 1.69 0.19
34 INT250835 Positive_regulation of Fgf8 1 0.50 0.42 0.14
35 INT99718 Positive_regulation of Gene_expression of FGFR2 9 0.49 4.47 0.12
36 INT211949 Negative_regulation of Sox9 1 0.31 0.83 0.12
37 INT184220 Negative_regulation of Gene_expression of SOX9 4 0.36 0.58 0.09
38 INT211948 Regulation of Gene_expression of Sox9 2 0.33 0.94 0.08
39 INT210242 Positive_regulation of Sox9 3 0.43 0.35 0.06
40 INT211939 Regulation of Sox9 1 0.33 0.35 0.06
41 INT303546 Binding of Fgfr2 1 0.46 0.74 0.06
42 INT260760 Positive_regulation of Fgf10 2 0.53 0.43 0.03
43 INT225365 Binding of Sox9 2 0.28 0.48 0.03
44 INT145302 Positive_regulation of Sox9 2 0.48 1.42 0.03
45 INT303535 Positive_regulation of Gene_expression of Fgf10 1 0.53 0.34 0.03
46 INT303525 Localization of Fgfr2 1 0.72 0.28 0.03
47 INT303547 Positive_regulation of Negative_regulation of Fgfr2 1 0.48 1.07 0.03
48 INT162339 Regulation of Gene_expression of SOX9 4 0.32 0.42 0
49 INT207729 Regulation of FGFR2 4 0.22 2.35 0
50 INT245757 Localization of SOX9 4 0.62 0.8 0
51 INT238985 Positive_regulation of FGFR2 3 0.49 1.19 0
52 INT211945 Negative_regulation of Gene_expression of Sox9 3 0.44 0.63 0
53 INT99716 Transcription of FGFR2 2 0.34 0.22 0
54 INT305351 Positive_regulation of Regulation of FGFR2 2 0.37 0.97 0
55 INT99715 Regulation of Gene_expression of FGFR2 2 0.22 0.19 0
56 INT303555 Negative_regulation of Gene_expression of FGFR2 2 0.41 0.31 0
57 INT322883 Regulation of Transcription of Sox9 1 0.43 0.18 0
58 INT202623 Negative_regulation of Gene_expression of Fgfr2 1 0.32 0 0
59 INT319036 Gene_expression of Fgfr2 1 0.48 0.08 0
60 INT211943 Transcription of Sox9 1 0.50 0.3 0
61 INT323815 Negative_regulation of Transcription of SOX9 1 0.41 0.18 0
62 INT322886 Transcription of Sox9 1 0.50 0.25 0
63 INT303380 Protein_catabolism of TCAP 1 0.64 0 0
64 INT145307 Positive_regulation of Positive_regulation of Sox9 1 0.48 0.07 0
65 INT250830 Regulation of Protein_catabolism of Fgf8 1 0.45 0.08 0
66 INT311651 Positive_regulation of Fgf8 1 0.46 0.26 0
67 INT245752 Positive_regulation of Binding of SOX9 1 0.41 0.48 0
68 INT99717 Positive_regulation of Transcription of FGFR2 1 0.10 0.08 0
69 INT183117 Positive_regulation of Binding of FGFR2 1 0.09 0.81 0
70 INT250846 Positive_regulation of Protein_catabolism of Fgf8 1 0.50 0.07 0
71 INT245765 Binding of SOX9 1 0.31 0.87 0
72 INT312245 Positive_regulation of Localization of SOX9 1 0.10 0 0
73 INT303524 Positive_regulation of Fgfr2 1 0.66 0.22 0
74 INT352010 Protein_catabolism of Sox9 1 0.22 0.07 0
75 INT308349 Positive_regulation of Gene_expression of Sox9 1 0.40 0.69 0
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