GO:0030917

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Name midbrain-hindbrain boundary development
Categary Process
Go Slim No
Go Link GO:0030917
Unique Molecular Interactions 36
Total Molecular Interactions 56
Total Single Events 223
Pain Genes Associated 7

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for midbrain-hindbrain boundary development. They are ordered first by their pain relevance and then by number of times they were reported for midbrain-hindbrain boundary development. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT250867 Fgf8 Positive_regulation of Protein_catabolism of Ecm1 1 0.06 4.35 2.14
2 INT250868 Fgf8 Positive_regulation of Gene_expression of Mmp3 1 0.15 1.73 0.93
3 INT250861 Fgf8 Positive_regulation of Gene_expression of Ptger2 1 0.04 1.51 0.84
4 INT250852 Fgf8 Negative_regulation of Gene_expression of Ecm1 1 0.04 1.1 0.54
5 INT228055 WNT1 Positive_regulation of CTNND2 1 0.54 1.75 0.42
6 INT250870 Fgf8 Positive_regulation of Ecm1 1 0.04 0.79 0.38
7 INT340609 Bdnf Regulation of Gene_expression of Wnt3a 1 0.53 0.31 0.36
8 INT250856 Fgf8 Positive_regulation of Localization of Mmp3 1 0.11 0.51 0.3
9 INT250864 Fgf8 Positive_regulation of Positive_regulation of Ptger2 1 0.03 0.55 0.28
10 INT250854 Fgf8 Positive_regulation of Positive_regulation of Mmp3 1 0.11 0.55 0.28
11 INT250873 Fgf8 Positive_regulation of GAG 1 0.55 0.48 0.23
12 INT340608 Binding of Creb1 and Wnt3a 1 0.30 0.24 0.14
13 INT250863 Fgf8 Positive_regulation of Ptger2 1 0.03 0.19 0.14
14 INT250866 Binding of Fgfr4 and Fgf8 1 0.12 0.35 0.11
15 INT250860 Fgf8 Regulation of Localization of Ptger2 1 0.02 0.13 0.1
16 INT287887 WNT1 Positive_regulation of Localization of BMP4 1 0.04 1.13 0.1
17 INT250862 Fgf8 Regulation of Localization of Mmp3 1 0.13 0.13 0.1
18 INT250859 Fgf8 Negative_regulation of Gene_expression of Mmp3 1 0.09 0.12 0.09
19 INT250872 Fgf8 Positive_regulation of Mmp3 1 0.11 0.12 0.09
20 INT250865 Binding of Fgf8 and Fgfr3 1 0.18 0.3 0.05
21 INT287877 WNT1 Positive_regulation of Localization of WISP1 1 0.03 0.56 0.05
22 INT287889 WNT1 Positive_regulation of KRT20 1 0.00 0.56 0.05
23 INT250855 Binding of Fgfr2 and Fgf8 1 0.12 0.3 0.05
24 INT311655 Shh Positive_regulation of Gene_expression of Fgf8 1 0.31 0.18 0.03
25 INT302321 Negative_regulation of Binding of Lrp6 and SOST 1 0.16 0.26 0
26 INT251072 Wnt3a Positive_regulation of Axin2 1 0.23 0.29 0
27 INT326893 Binding of Tcf4 and Wnt3a 1 0.13 0 0
28 INT311656 Binding of Wnt1 and Spry1 1 0.30 0.39 0
29 INT302320 Binding of Lrp6 and SOST 1 0.18 0.26 0
30 INT268521 Binding of WNT1 and MIR221 1 0.02 1.36 0
31 INT297855 Binding of Ndp and Wnt1 1 0.38 1.18 0
32 INT335887 Akt1 Regulation of Lrp6 1 0.06 0.15 0
33 INT326896 Wnt3a Positive_regulation of Transcription of PLD2 1 0.24 0.06 0
34 INT335883 Binding of Lrp6 and Wnt5a 1 0.27 0.08 0
35 INT251070 Wnt3a Positive_regulation of Cldn3 1 0.30 0.29 0
36 INT326894 Wnt3a Positive_regulation of Transcription of Pld1 1 0.24 0.06 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for midbrain-hindbrain boundary development. They are ordered first by their pain relevance and then by number of times they were reported in midbrain-hindbrain boundary development. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT340600 Gene_expression of Wnt3a 1 0.68 2.14 9.14
2 INT250832 Gene_expression of Fgf8 1 0.77 13.36 6.2
3 INT340603 Regulation of Gene_expression of Wnt3a 1 0.54 0.49 3.75
4 INT340595 Positive_regulation of Gene_expression of Wnt3a 1 0.61 0.86 3.11
5 INT141833 Gene_expression of WNT1 14 0.75 10.57 2.1
6 INT29035 Negative_regulation of Wnt1 3 0.41 1.47 2
7 INT250841 Positive_regulation of Gene_expression of Fgf8 1 0.69 3.8 1.72
8 INT340596 Negative_regulation of Gene_expression of Wnt3a 1 0.51 0.38 1.4
9 INT250850 Negative_regulation of Gene_expression of Fgf8 1 0.42 2.79 1.33
10 INT141834 Negative_regulation of Gene_expression of WNT1 3 0.57 1.31 1.2
11 INT108519 Binding of Lrp6 8 0.44 1.47 1.19
12 INT250840 Negative_regulation of Fgf8 1 0.43 1.92 1.11
13 INT277461 Positive_regulation of Gene_expression of Fgf8 1 0.24 0.47 1.05
14 INT340604 Regulation of Wnt3a 1 0.24 0 0.95
15 INT141835 Negative_regulation of WNT1 2 0.41 1.02 0.83
16 INT202628 Gene_expression of Wnt1 20 0.67 9.2 0.82
17 INT250845 Protein_catabolism of Fgf8 1 0.98 1.64 0.48
18 INT268007 Gene_expression of Fgf8 8 0.72 1.38 0.47
19 INT340598 Binding of Wnt3a 1 0.33 0.15 0.46
20 INT228057 Positive_regulation of WNT1 1 0.49 1.8 0.44
21 INT277465 Regulation of Gene_expression of Fgf8 2 0.25 0.43 0.43
22 INT340606 Positive_regulation of Wnt3a 1 0.61 0.49 0.4
23 INT216379 Positive_regulation of Gene_expression of WNT1 5 0.30 3.1 0.34
24 INT250826 Transcription of Fgf8 1 0.71 0.71 0.34
25 INT51514 Positive_regulation of Wnt3a 3 0.04 3.32 0.28
26 INT335875 Regulation of Lrp6 1 0.57 0.43 0.27
27 INT250836 Binding of Fgf8 3 0.35 0.66 0.24
28 INT250833 Localization of Fgf8 1 0.74 0.46 0.21
29 INT250842 Negative_regulation of Binding of Fgf8 1 0.43 0.33 0.21
30 INT353965 Negative_regulation of Gene_expression of Wnt1 1 0.41 0 0.18
31 INT335861 Localization of Lrp6 1 0.69 0.54 0.17
32 INT217569 Binding of Wnt1 2 0.36 1.07 0.15
33 INT250835 Positive_regulation of Fgf8 1 0.50 0.42 0.14
34 INT51512 Negative_regulation of Positive_regulation of Wnt3a 1 0.04 1.3 0.13
35 INT51513 Positive_regulation of Positive_regulation of Wnt3a 1 0.04 1.31 0.13
36 INT266241 Regulation of Wnt1 1 0.26 0.59 0.09
37 INT214463 Binding of Wnt3a 2 0.26 0.23 0.08
38 INT335865 Positive_regulation of Phosphorylation of Lrp6 1 0.64 0.46 0.05
39 INT335862 Phosphorylation of Lrp6 1 0.76 0.37 0.05
40 INT304937 Transcription of Wnt1 1 0.22 0.65 0.05
41 INT287956 Regulation of WNT1 2 0.26 2.38 0.04
42 INT311648 Regulation of Gene_expression of Wnt1 1 0.39 0.09 0.04
43 INT287936 Regulation of Gene_expression of WNT1 1 0.20 1.06 0.04
44 INT202633 Positive_regulation of Gene_expression of Wnt1 3 0.43 0.85 0
45 INT214465 Localization of Wnt3a 2 0.52 0.29 0
46 INT251053 Gene_expression of Wnt3a 2 0.47 0.5 0
47 INT326853 Positive_regulation of Gene_expression of Wnt3a 1 0.36 0.2 0
48 INT335872 Positive_regulation of Gene_expression of Lrp6 1 0.46 0.18 0
49 INT337424 Phosphorylation of Wnt1 1 0.79 0 0
50 INT251054 Regulation of Localization of Wnt3a 1 0.27 0.07 0
51 INT250830 Regulation of Protein_catabolism of Fgf8 1 0.45 0.08 0
52 INT311651 Positive_regulation of Fgf8 1 0.46 0.26 0
53 INT311632 Positive_regulation of Wnt1 1 0.43 0.19 0
54 INT235058 Localization of Wnt1 1 0.64 0.56 0
55 INT251066 Regulation of Gene_expression of Wnt3a 1 0.31 0.07 0
56 INT250846 Positive_regulation of Protein_catabolism of Fgf8 1 0.50 0.07 0
57 INT347117 Negative_regulation of Binding of Lrp6 1 0.28 0.5 0
58 INT335866 Regulation of Transcription of Lrp6 1 0.42 0.25 0
59 INT326843 Negative_regulation of Gene_expression of Wnt3a 1 0.22 0.29 0
60 INT335881 Gene_expression of Lrp6 1 0.62 0.09 0
61 INT335873 Transcription of Lrp6 1 0.64 0.25 0
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