GO:0031012

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Name extracellular matrix
Categary Component
Go Slim No
Go Link GO:0031012
Unique Molecular Interactions 1880
Total Molecular Interactions 2503
Total Single Events 20337
Pain Genes Associated 178

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for extracellular matrix. They are ordered first by their pain relevance and then by number of times they were reported for extracellular matrix. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT251170 Clu Positive_regulation of Trpv1 1 0.28 2.61 6.49
2 INT7436 CFP Positive_regulation of Binding of POMC 1 0.02 0.18 3.35
3 INT215943 Binding of Mmp14 and Timp2 1 0.21 1.59 3.33
4 INT251164 Binding of Clu and Trpv1 1 0.19 0.44 2.23
5 INT250867 Fgf8 Positive_regulation of Protein_catabolism of Ecm1 1 0.06 4.35 2.14
6 INT189999 Binding of Vta1 and Cfp 2 0.08 1.25 1.97
7 INT113550 Binding of FN1 and VTN 6 0.30 5.24 1.91
8 INT243043 Binding of Mmp9 and Timp1 1 0.05 0.25 1.86
9 INT192161 Mmp14 Positive_regulation of Mmp2 2 0.19 1.23 1.81
10 INT102160 Binding of Mmp2 and Mmp9 3 0.28 2.87 1.75
11 INT24817 Binding of POMC and VTN 8 0.42 0.39 1.71
12 INT24689 Binding of PLAT and Serpine1 1 0.00 3.77 1.64
13 INT147108 TGFB1 Positive_regulation of Gene_expression of FN1 4 0.47 1.01 1.63
14 INT168612 Negative_regulation of Nos1 Negative_regulation of Positive_regulation of Mmp9 1 0.23 0.45 1.62
15 INT168607 Negative_regulation of Nos1 Negative_regulation of Mmp9 1 0.23 0.45 1.61
16 INT326509 Binding of ACE and VWF 1 0.05 2.07 1.59
17 INT168609 Binding of Itgb1 and Mmp9 1 0.02 0.41 1.58
18 INT168611 Binding of Mmp9 and Ndor1 1 0.29 0.41 1.57
19 INT168608 Binding of Grin2b and Mmp9 1 0.22 0.41 1.57
20 INT261831 Mapk1 Negative_regulation of Hspg2 1 0.00 1.26 1.42
21 INT56093 FGFR1 Regulation of Gene_expression of SERPINE1 1 0.23 1.71 1.37
22 INT158762 Binding of Vwf and Mthfr 1 0.05 1.85 1.37
23 INT157460 CX3CL1 Regulation of Gene_expression of COL1A1 1 0.11 1.57 1.37
24 INT56087 TNF Regulation of Gene_expression of SERPINE1 1 0.43 1.67 1.33
25 INT194513 Timp1 Negative_regulation of Cpox 1 0.00 0.9 1.31
26 INT351245 Binding of TNC and OPN1LW 1 0.03 0.89 1.31
27 INT262377 Binding of Comt and Fmod 1 0.06 1.47 1.29
28 INT18659 Plat Regulation of ZC3H12D 1 0.02 0.1 1.29
29 INT42579 SOD1 Negative_regulation of POMC 1 0.16 0.43 1.27
30 INT343949 SERPINE2 Positive_regulation of Positive_regulation of Slco1c1 1 0.00 0.59 1.27
31 INT151658 F3 Regulation of Gene_expression of ICAM1 1 0.00 2.86 1.24
32 INT311914 Il1 Negative_regulation of Gene_expression of Col2a1 1 0.01 1.94 1.23
33 INT264333 IL-17 Positive_regulation of Gene_expression of Mmp1a 1 0.05 2.88 1.18
34 INT72754 Adamts7 Negative_regulation of TNF 1 0.28 1.64 1.13
35 INT203103 ACAN Negative_regulation of Gene_expression of IL10 1 0.02 1.31 1.12
36 INT134487 Positive_regulation of TGFBI Positive_regulation of Ltp 1 0.03 1.19 1.11
37 INT101715 PLAT Positive_regulation of NFKB1 2 0.11 0.99 1.09
38 INT150794 ZNF398 Positive_regulation of Localization of THBS1 1 0.09 1.02 1.07
39 INT343950 SERPINE2 Positive_regulation of Slco1c1 1 0.00 1.63 1.07
40 INT263048 Tgfb1 Positive_regulation of Gene_expression of Mmp2 1 0.13 0.81 1.07
41 INT139227 Icam1 Negative_regulation of Timp1 1 0.37 1.13 1.06
42 INT150789 THBS3 Negative_regulation of THBS1 1 0.18 1.01 1.06
43 INT116777 Psma5 Positive_regulation of Binding of Fn1 1 0.01 1.24 1.06
44 INT139231 Calca Negative_regulation of Timp1 1 0.36 1.11 1.05
45 INT204551 Binding of Col2a1 and Positive_regulation of Cia1 1 0.03 1.74 1.03
46 INT106706 POMC Negative_regulation of Binding of FN1 1 0.19 0.79 1.02
47 INT143177 Apcs Negative_regulation of Gene_expression of Fos 1 0.02 0.36 1.01
48 INT344973 Negative_regulation of Mmp23 Regulation of Negative_regulation of Mag 1 0.01 1.14 0.99
49 INT130232 Binding of Cat and Sod1 1 0.35 0.3 0.98
50 INT130231 Positive_regulation of Binding of Cat and Sod1 1 0.46 0.3 0.98
51 INT296179 Pla2g2a Positive_regulation of Apcs 1 0.17 7.13 0.96
52 INT289173 PYCARD Regulation of MFGE8 1 0.05 0 0.96
53 INT165941 Bmp7 Positive_regulation of Penk 1 0.28 0.43 0.95
54 INT165942 Bmp7 Positive_regulation of Transcription of Pomc 1 0.29 0.43 0.95
55 INT165940 Bmp7 Positive_regulation of Pomc 1 0.29 0.43 0.95
56 INT106707 POMC Regulation of Binding of LAMB2 1 0.03 0.7 0.94
57 INT222979 Negative_regulation of Binding of COL1A1 and FN1 1 0.01 1.64 0.93
58 INT250868 Fgf8 Positive_regulation of Gene_expression of Mmp3 1 0.15 1.73 0.93
59 INT222978 Binding of COL1A1 and FN1 1 0.01 1.64 0.92
60 INT243044 Mmp8 Regulation of Mmp9 1 0.05 1.45 0.91
61 INT250976 Binding of FMOD and IL8 1 0.08 1.26 0.91
62 INT247759 Binding of Ccrl2 and Rarres2 1 0.26 1.19 0.9
63 INT48341 Negative_regulation of Pde8a Regulation of Ahsg 1 0.22 0 0.9
64 INT48342 Pde8a Regulation of Ahsg 1 0.24 0 0.9
65 INT222988 TNF Positive_regulation of Protein_catabolism of COL1A1 1 0.01 1.66 0.9
66 INT169477 TGFB3 Positive_regulation of Spink3 1 0.02 1.83 0.89
67 INT166983 Binding of HLA-B and HSPG2 4 0.08 4.66 0.88
68 INT167466 Ccdc80 Negative_regulation of Tnf 1 0.01 0.76 0.88
69 INT149559 Tgfb1 Positive_regulation of Gene_expression of Ccr5 1 0.00 0 0.88
70 INT149562 Tgfb1 Positive_regulation of CXCL10 1 0.00 0 0.88
71 INT149564 Tgfb1 Positive_regulation of Gene_expression of CXCL10 1 0.00 0 0.88
72 INT149560 Tgfb1 Positive_regulation of Ccr5 1 0.00 0 0.88
73 INT251159 Binding of Clu and Positive_regulation of Trpv1 1 0.16 0 0.87
74 INT154257 Binding of Prss12 and Cfp 1 0.02 0 0.87
75 INT194856 Positive_regulation of Adora2b Negative_regulation of Positive_regulation of Mmp13 1 0.01 0.73 0.85
76 INT140985 Gli3 Regulation of Ihh 1 0.29 0.85 0.85
77 INT107698 FN1 Positive_regulation of Gene_expression of CPOX 1 0.13 0.26 0.84
78 INT183176 Binding of FGFR2 and NUDT6 1 0.05 1.07 0.84
79 INT129881 Binding of Calr and Cbll1 1 0.00 0.58 0.84
80 INT149561 Tgfb1 Positive_regulation of Gene_expression of CCL2 1 0.00 0 0.83
81 INT192158 Binding of Mmp2 and Mmp9 1 0.21 0.94 0.83
82 INT309001 Ins1 Positive_regulation of Mmp9 1 0.20 1.96 0.83
83 INT149563 Tgfb1 Positive_regulation of CCL2 1 0.00 0 0.83
84 INT149558 Tgfb1 Positive_regulation of Gene_expression of Cxcr4 1 0.00 0 0.82
85 INT335404 Binding of Arntl and Hspg2 1 0.06 0.93 0.82
86 INT335403 Binding of Hspg2 and Npas2 1 0.04 0.93 0.82
87 INT114844 Lgals1 Positive_regulation of TACR1 1 0.16 0.95 0.82
88 INT149557 Tgfb1 Positive_regulation of Gene_expression of Ccl5 1 0.00 0 0.82
89 INT144449 Plscr1 Positive_regulation of Gene_expression of Nqo1 1 0.15 0.18 0.8
90 INT135781 Cyp3a23/3a1 Positive_regulation of Positive_regulation of Col1a1 1 0.01 0.78 0.8
91 INT209043 Binding of Fn1 and Slc11a1 3 0.03 1.91 0.78
92 INT102163 Binding of TNF and Mmp9 1 0.12 0.88 0.78
93 INT113546 Binding of FN1 and ITGA3 1 0.03 2.12 0.77
94 INT147913 Phosphorylation of Camk2a Positive_regulation of Binding of Lpl 1 0.10 0 0.77
95 INT166222 Gene_expression of Fos Positive_regulation of Col6a6 1 0.01 0.57 0.77
96 INT224463 TPSAB1 Positive_regulation of F2RL1 2 0.03 1.49 0.76
97 INT113549 Binding of VTN and alphavbeta3 integrin receptor 1 0.09 2.05 0.76
98 INT161945 TGFB2 Positive_regulation of TGFBR1 1 0.08 0.99 0.76
99 INT125523 PLAT Positive_regulation of GDF15 1 0.13 1.33 0.75
100 INT250959 Binding of HLA-B and SOD1 1 0.05 0.75 0.75
101 INT113472 TNF Positive_regulation of Localization of MMP14 1 0.47 0.45 0.75
102 INT120848 Sp6 Positive_regulation of Gene_expression of Ndp 1 0.14 0.52 0.74
103 INT161949 TGFB2 Positive_regulation of Gene_expression of Ngf 1 0.21 0.97 0.74
104 INT170992 Binding of FN1 and MMRN1 3 0.01 2.13 0.73
105 INT162241 Binding of COL7A1 and MMP13 2 0.03 0.86 0.73
106 INT58870 Binding of ap and Bgn 1 0.13 0 0.72
107 INT296097 Acsm3 Negative_regulation of SOD1 1 0.01 1.3 0.72
108 INT262580 Ngf Positive_regulation of Hspg2 1 0.03 0.35 0.72
109 INT251169 Clu Regulation of Ca2 1 0.03 0.66 0.7
110 INT348129 Bgn Regulation of Regulation of Hspg2 1 0.00 0.69 0.69
111 INT224678 Binding of Mmp14 and Mmp23 1 0.00 0.85 0.69
112 INT346225 Binding of PRTN3 and Flg 1 0.01 1.74 0.69
113 INT263049 Positive_regulation of Binding of Mmp2 and Mmp9 1 0.35 0.83 0.69
114 INT250871 Il1a Positive_regulation of Protein_catabolism of Ecm1 1 0.01 1.44 0.68
115 INT321479 Ubqln1 Regulation of Cfp 1 0.00 0.37 0.67
116 INT251166 Clu Positive_regulation of Trpc3 1 0.09 0.75 0.67
117 INT251171 Clu Positive_regulation of C6 1 0.05 0.75 0.67
118 INT335054 LPL Positive_regulation of Localization of VLDLR 1 0.04 1.48 0.67
119 INT61798 Binding of NDP and POMC 2 0.22 0 0.66
120 INT130355 spc Regulation of Serpine1 1 0.14 0.2 0.66
121 INT152298 Mmp9 Negative_regulation of Tsc22d1 1 0.13 0.16 0.66
122 INT114843 NTRK1 Regulation of Gene_expression of Lgals1 1 0.06 0.84 0.66
123 INT152296 Regulation of Mmp9 Negative_regulation of Tsc22d1 1 0.08 0.16 0.66
124 INT130354 Adcy10 Regulation of Serpine1 1 0.17 0.2 0.66
125 INT152297 Mmp2 Negative_regulation of Mmp9 1 0.39 0.16 0.65
126 INT224683 Mmp14 Positive_regulation of Binding of Mmp9 1 0.01 0.81 0.65
127 INT114845 RET Regulation of Gene_expression of Lgals1 1 0.02 0.84 0.65
128 INT224693 Timp2 Positive_regulation of Binding of Mmp9 1 0.01 0.81 0.65
129 INT149899 Ihh Positive_regulation of Mmp7 1 0.04 1.69 0.65
130 INT352462 Gse1 Positive_regulation of Gene_expression of Tnc 1 0.05 0.75 0.64
131 INT224684 Binding of Mmp14 and Mmp9 1 0.01 0.81 0.64
132 INT113473 RETNLB Positive_regulation of MMP14 1 0.01 0.37 0.64
133 INT251188 Clu Positive_regulation of TRPV1 1 0.01 0.23 0.64
134 INT261830 Hspg2 Negative_regulation of Trpa1 1 0.01 0.58 0.63
135 INT182266 EDN1 Positive_regulation of Gene_expression of MMP13 1 0.35 2.03 0.63
136 INT239488 Spna1 Negative_regulation of Gene_expression of Timp1 1 0.00 0.94 0.62
137 INT7402 Positive_regulation of Ucma Positive_regulation of Localization of Gast 1 0.50 0 0.62
138 INT314051 THL Negative_regulation of Localization of Mmp2 1 0.14 1.1 0.62
139 INT265707 Binding of NA and Cfp 1 0.01 0 0.62
140 INT8695 Binding of Calca and Lgals3 1 0.02 0.09 0.62
141 INT12610 IAPP Positive_regulation of LGALS1 1 0.07 0.09 0.61
142 INT137017 Tgfb1 Positive_regulation of Gene_expression of Acta2 1 0.00 0.84 0.61
143 INT12611 IAPP Positive_regulation of Localization of LGALS1 1 0.06 0.09 0.61
144 INT284089 Binding of NTRK2 and SERPINE1 1 0.27 0.73 0.61
145 INT95435 Il1a Positive_regulation of Positive_regulation of Mmp3 1 0.59 0.25 0.61
146 INT95436 Il1a Positive_regulation of Mmp3 1 0.59 0.25 0.61
147 INT67014 Penk Regulation of Regulation of Cfp 1 0.24 0 0.61
148 INT101718 PLAT Positive_regulation of Transcription of OPRM1 1 0.22 0.06 0.61
149 INT95434 Mmp9 Positive_regulation of Positive_regulation of Il1a 1 0.42 0.23 0.61
150 INT95433 Mmp3 Regulation of Mmp2 1 0.17 0.24 0.6
151 INT352459 Gse1 Regulation of Gene_expression of Tnc 1 0.05 0 0.6
152 INT179850 Binding of Ecm1 and Il11 1 0.02 0 0.6
153 INT95432 Il1a Positive_regulation of Positive_regulation of Mmp9 1 0.37 0.25 0.6
154 INT251167 Clu Positive_regulation of Trpc6 1 0.12 0.2 0.6
155 INT101719 PLAT Positive_regulation of NFYC 1 0.13 0.1 0.6
156 INT95430 Mmp9 Positive_regulation of Mmp3 1 0.38 0.24 0.6
157 INT53312 Adarb1 Regulation of Regulation of Cfp 1 0.02 0.2 0.6
158 INT178087 EDN1 Positive_regulation of MMP13 2 0.23 1.58 0.59
159 INT101717 PLAT Positive_regulation of JUND 1 0.17 0.1 0.59
160 INT251168 Clu Positive_regulation of Trpc7 1 0.15 0.2 0.59
161 INT250326 Binding of Il12a and Rpsa 1 0.09 0.93 0.59
162 INT77380 Tmie Negative_regulation of Fbln5 1 0.01 0 0.59
163 INT65285 TGFBI Negative_regulation of Pc 1 0.20 0.79 0.59
164 INT37034 PLAT Positive_regulation of PLDN 1 0.08 0.15 0.58
165 INT345303 MMP15 Positive_regulation of MMP13 1 0.00 1.18 0.58
166 INT37035 PLAT Negative_regulation of ODC1 1 0.45 0.15 0.58
167 INT342624 VEGFA Negative_regulation of Mmp2 1 0.09 1.54 0.58
168 INT144071 TRPV1 Positive_regulation of Gene_expression of MMP14 1 0.21 0.5 0.58
169 INT302833 Gene_expression of Mir155 Negative_regulation of Gene_expression of Mmp3 1 0.03 1 0.57
170 INT342619 Mmp2 Negative_regulation of Timp2 1 0.42 1.48 0.57
171 INT71110 Binding of MC1R and NDP 1 0.10 0 0.57
172 INT335995 Il10 Negative_regulation of Tgfb1 1 0.06 0.83 0.57
173 INT56088 TGFB1 Positive_regulation of Transcription of SERPINE1 1 0.46 0.83 0.57
174 INT345302 MMP15 Positive_regulation of MMP2 1 0.06 1.17 0.57
175 INT239489 Spna1 Negative_regulation of Timp1 1 0.00 0.89 0.57
176 INT75992 Binding of Pvalb and Lgals3 1 0.00 0 0.56
177 INT145718 Positive_regulation of Plat Positive_regulation of Bdnf 1 0.20 0 0.56
178 INT227911 Binding of VTN and MMRN1 1 0.01 1.16 0.56
179 INT190702 CD40 Positive_regulation of Gene_expression of F3 1 0.00 1.4 0.55
180 INT114029 Binding of ALB and Mmp3 1 0.01 0.31 0.55
181 INT114028 Negative_regulation of Binding of ALB and Mmp3 1 0.01 0.31 0.55
182 INT129270 Binding of Wnt4 and Efs 1 0.00 0 0.55
183 INT250852 Fgf8 Negative_regulation of Gene_expression of Ecm1 1 0.04 1.1 0.54
184 INT316736 Il1 Positive_regulation of Timp1 1 0.04 0.63 0.54
185 INT316737 Il1 Positive_regulation of Mmp1a 1 0.01 0.64 0.54
186 INT282711 Binding of Csf2 and Mmp9 1 0.16 1.35 0.54
187 INT202043 MMP13 Regulation of Protein_catabolism of COL2A1 1 0.01 0.54 0.54
188 INT132372 Lgals1 Positive_regulation of Ephb1 1 0.37 0.25 0.54
189 INT316738 Il1 Positive_regulation of Mmp3 1 0.02 0.63 0.54
190 INT223934 HSPG2 Negative_regulation of Gene_expression of Cux1 1 0.03 0 0.53
191 INT314043 THL Negative_regulation of Mmp2 1 0.22 2.11 0.53
192 INT192162 Furin Positive_regulation of Mmp14 1 0.10 0.79 0.53
193 INT235876 Hspg2 Positive_regulation of Prkca 1 0.03 0.23 0.53
194 INT150791 THBS1 Negative_regulation of TIMP2 1 0.17 0.5 0.52
195 INT92918 Atp6v0a2 Negative_regulation of Gene_expression of Tgfb1 1 0.01 0.83 0.52
196 INT356351 Binding of CALM1 and TNC 1 0.02 0 0.52
197 INT194915 Csf2 Positive_regulation of Gene_expression of Mmp1a 1 0.01 0.85 0.52
198 INT192159 Mmp14 Regulation of Protein_catabolism of Col1a1 1 0.02 1.01 0.52
199 INT150796 ZNF398 Positive_regulation of THBS1 1 0.06 0.5 0.52
200 INT205728 Mmp9 Positive_regulation of Gene_expression of Mmp3 1 0.29 0 0.52

Single Events

The table below shows the top 100 pain related interactions that have been reported for extracellular matrix. They are ordered first by their pain relevance and then by number of times they were reported in extracellular matrix. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT24989 Positive_regulation of Cfp 125 0.61 29.55 64.9
2 INT96937 Gene_expression of Mmp9 191 0.75 150.3 56.01
3 INT115384 Positive_regulation of Mmp9 121 0.68 94.74 43.02
4 INT68975 Gene_expression of Mmp9 111 0.78 79.57 38.55
5 INT17736 Gene_expression of Cfp 111 0.65 40.68 36.61
6 INT45365 Negative_regulation of Cfp 68 0.57 25.44 32.11
7 INT68973 Positive_regulation of Mmp9 89 0.52 58.56 30.04
8 INT11361 Gene_expression of SERPINE1 183 0.78 136.45 27.97
9 INT48202 Gene_expression of Tgfb1 146 0.78 89.93 27.76
10 INT59449 Negative_regulation of Timp1 76 0.42 54.86 26.99
11 INT129956 Gene_expression of MMP13 145 0.72 60.48 26.98
12 INT140193 Gene_expression of Mmp3 58 0.71 49.65 25.4
13 INT93717 Gene_expression of Mmp3 85 0.78 33.95 24.89
14 INT86295 Gene_expression of Mmp2 114 0.76 73.68 24.25
15 INT72370 Gene_expression of Timp1 82 0.65 57.52 24.16
16 INT16996 Gene_expression of PRTN3 113 0.75 85.61 22.57
17 INT28728 Regulation of Cfp 49 0.46 13.15 21.43
18 INT170313 Gene_expression of Mmp1a 50 0.65 38.53 21.36
19 INT50814 Positive_regulation of Mmp2 72 0.68 51.37 20.42
20 INT116282 Gene_expression of Mmp13 83 0.75 45.4 20.18
21 INT14737 Gene_expression of FN1 117 0.78 78.74 18.99
22 INT9900 Positive_regulation of Vwf 80 0.69 51.85 18.13
23 INT7439 Positive_regulation of CFP 52 0.67 19.97 17.87
24 INT132997 Localization of Mmp9 59 0.80 45.9 17.61
25 INT95767 Negative_regulation of Mmp9 72 0.57 49.14 17.1
26 INT17313 Positive_regulation of HSPG2 57 0.67 55.78 16.65
27 INT99898 Gene_expression of Mmp14 37 0.56 28.54 16.39
28 INT11508 Positive_regulation of TGFBI 24 0.70 19.81 15.78
29 INT19963 Gene_expression of COL1A1 118 0.59 42.11 15.15
30 INT113606 Positive_regulation of Gene_expression of Mmp9 46 0.64 44 15.07
31 INT1284 Negative_regulation of Mmp13 20 0.57 36.21 14.91
32 INT11636 Positive_regulation of SERPINE1 85 0.69 68.73 14.8
33 INT66611 Localization of Cfp 22 0.65 7.04 14.64
34 INT36336 Gene_expression of Tgfb1 41 0.77 21.82 14.53
35 INT59870 Gene_expression of F3 51 0.65 51.83 14.01
36 INT55740 Gene_expression of Timp1 53 0.75 28.63 13.85
37 INT15684 Positive_regulation of Serpine1 65 0.70 43.51 13.67
38 INT24684 Localization of PLAT 30 0.78 26.21 13.56
39 INT15921 Positive_regulation of Serpine1 85 0.68 81.24 13.4
40 INT95427 Positive_regulation of Mmp3 39 0.70 15.28 13.36
41 INT20632 Gene_expression of TNC 72 0.78 30.43 13.16
42 INT20102 Gene_expression of Serpine1 102 0.78 65.99 12.61
43 INT31990 Positive_regulation of SOD1 124 0.69 67.79 12.52
44 INT123779 Positive_regulation of MMP13 42 0.65 24.3 12.45
45 INT158124 Gene_expression of COL5A2 136 0.69 72.3 12.44
46 INT14510 Gene_expression of SOD1 208 0.76 88.56 12.4
47 INT96924 Positive_regulation of Hspg2 40 0.49 14.5 12.32
48 INT32054 Gene_expression of Tnc 14 0.59 9.36 12.22
49 INT46695 Positive_regulation of TNC 28 0.67 17.06 12.04
50 INT37618 Gene_expression of Col2a1 50 0.70 33.88 11.58
51 INT68976 Positive_regulation of Gene_expression of Mmp9 34 0.42 28.21 11.28
52 INT48203 Positive_regulation of Tgfb1 67 0.70 41.31 11.07
53 INT86291 Negative_regulation of Mmp2 33 0.57 20.38 10.76
54 INT4806 Localization of TPSAB1 29 0.80 5.05 10.52
55 INT4297 Negative_regulation of CFP 21 0.42 12.7 10.29
56 INT262375 Binding of Fmod 1 0.20 12.37 10.1
57 INT113605 Negative_regulation of Gene_expression of Mmp9 25 0.41 22.92 9.98
58 INT2378 Negative_regulation of SERPINE1 47 0.59 34.55 9.9
59 INT82829 Gene_expression of COMP 104 0.78 57 9.81
60 INT15449 Positive_regulation of Plat 32 0.69 12.76 9.71
61 INT140191 Positive_regulation of Gene_expression of Mmp13 25 0.67 13.47 9.71
62 INT58986 Gene_expression of Clu 17 0.77 8.35 9.61
63 INT54834 Gene_expression of Col2a1 48 0.72 13.5 9.41
64 INT125247 Negative_regulation of Mmp9 42 0.43 23.68 9.37
65 INT9899 Gene_expression of Vwf 91 0.74 45.06 9.13
66 INT76860 Gene_expression of HSPG2 32 0.65 37.14 9.06
67 INT173587 Protein_catabolism of COL5A2 59 0.32 32.73 8.96
68 INT111397 Localization of Timp1 17 0.70 11.67 8.76
69 INT250978 Binding of FMOD 4 0.16 12.32 8.75
70 INT97331 Positive_regulation of Timp1 20 0.45 13.32 8.57
71 INT129962 Positive_regulation of Gene_expression of MMP13 41 0.65 20.74 8.54
72 INT15723 Gene_expression of Fn1 47 0.78 37.59 8.51
73 INT45914 Gene_expression of Apcs 22 0.65 24.25 8.48
74 INT17024 Gene_expression of COL1A2 69 0.77 36.38 8.29
75 INT44003 Gene_expression of F3 40 0.75 27.92 8.29
76 INT24141 Negative_regulation of Apcs 24 0.59 16.82 8.29
77 INT96068 Positive_regulation of Timp1 30 0.58 23.94 8.17
78 INT60034 Positive_regulation of VWF 40 0.68 30.42 8.15
79 INT79166 Regulation of TNC 12 0.44 9.42 8.13
80 INT8694 Binding of Lgals3 38 0.48 14.82 8.05
81 INT94122 Negative_regulation of Mmp23 21 0.37 15.81 8.03
82 INT15725 Positive_regulation of Fn1 17 0.67 14.93 8.03
83 INT67037 Gene_expression of Sod1 121 0.78 59.32 7.99
84 INT1925 Gene_expression of PLAT 47 0.75 34.76 7.88
85 INT113671 Negative_regulation of Mmp3 26 0.49 6.33 7.88
86 INT15918 Gene_expression of Serpine1 60 0.62 41.73 7.72
87 INT79168 Binding of TNC 39 0.47 16.51 7.55
88 INT153371 Binding of Cfp 27 0.47 7.33 7.48
89 INT14732 Positive_regulation of FN1 46 0.69 31.17 7.33
90 INT64523 Binding of Ndp 10 0.33 2.72 7.29
91 INT10513 Gene_expression of Plat 44 0.76 19.49 7.17
92 INT111398 Localization of Mmp2 37 0.76 23.78 7.17
93 INT134967 Gene_expression of Ecm1 66 0.29 38.4 7.16
94 INT168381 Positive_regulation of Mmp3 24 0.58 19.12 7.03
95 INT75382 Negative_regulation of HSPG2 20 0.57 15.18 7.03
96 INT61120 Positive_regulation of Gene_expression of Tgfb1 34 0.70 21.15 6.93
97 INT168600 Binding of Mmp9 14 0.44 12.79 6.92
98 INT14903 Negative_regulation of SOD1 81 0.57 42.02 6.91
99 INT81608 Gene_expression of Col11a1 13 0.15 1.58 6.87
100 INT53311 Positive_regulation of Gene_expression of Cfp 20 0.42 4.39 6.62
101 INT133889 Gene_expression of Adamts1 78 0.76 48.05 6.58
102 INT1926 Positive_regulation of PLAT 54 0.66 31.42 6.49
103 INT16997 Binding of PRTN3 34 0.48 33.44 6.45
104 INT171691 Protein_catabolism of Ecm1 31 0.20 11.57 6.38
105 INT17262 Negative_regulation of Plat 17 0.59 15.14 6.36
106 INT155780 Gene_expression of Mmp8 19 0.77 15.85 6.33
107 INT168383 Positive_regulation of Mmp13 27 0.67 17.9 6.27
108 INT47127 Gene_expression of BGN 11 0.75 17.09 6.25
109 INT8683 Positive_regulation of F3 31 0.67 42.89 6.21
110 INT82828 Positive_regulation of COMP 45 0.61 35.12 6.2
111 INT250982 Positive_regulation of FMOD 7 0.24 8.65 6.09
112 INT140503 Negative_regulation of Gene_expression of Mmp3 7 0.44 5.93 6.08
113 INT39758 Gene_expression of Fn1 57 0.65 34.38 6.02
114 INT152293 Regulation of Mmp9 9 0.49 6.57 6.01
115 INT123551 Regulation of Mmp2 17 0.57 11.6 6
116 INT19086 Negative_regulation of COL1A1 32 0.38 16.77 5.98
117 INT55655 Gene_expression of DCN 17 0.75 7.98 5.98
118 INT63822 Gene_expression of Mmp23 23 0.43 14.15 5.96
119 INT6913 Negative_regulation of Amelx 6 0.32 2.32 5.95
120 INT18677 Gene_expression of F3 50 0.65 30.86 5.86
121 INT131378 Negative_regulation of FN1 20 0.35 33.98 5.85
122 INT179810 Protein_catabolism of Ecm1 30 0.11 18.28 5.75
123 INT109124 Positive_regulation of TIMP3 8 0.61 5.57 5.72
124 INT55733 Negative_regulation of VTN 47 0.58 47.22 5.68
125 INT4938 Localization of Tnc 5 0.65 1.73 5.64
126 INT13170 Gene_expression of Comp 25 0.74 8.68 5.62
127 INT11360 Localization of SERPINE1 41 0.80 33.98 5.61
128 INT69944 Positive_regulation of Ndp 7 0.38 4.81 5.6
129 INT32458 Gene_expression of VWF 57 0.78 28.97 5.56
130 INT113254 Positive_regulation of MFGE8 13 0.09 2.52 5.56
131 INT63507 Gene_expression of SERPINE2 8 0.70 8.35 5.56
132 INT48201 Localization of Tgfb1 27 0.59 13.65 5.54
133 INT15284 Positive_regulation of Lgals3 21 0.47 8.88 5.52
134 INT174851 Positive_regulation of COL5A2 46 0.54 12.73 5.48
135 INT51337 Binding of Clu 3 0.12 0.05 5.45
136 INT4805 Positive_regulation of Localization of TPSAB1 9 0.55 0.32 5.38
137 INT138157 Regulation of Mmp3 12 0.54 6.12 5.36
138 INT48200 Transcription of Tgfb1 13 0.69 3.85 5.24
139 INT10888 Binding of Vwf 32 0.46 22.87 5.21
140 INT67868 Negative_regulation of Gene_expression of Tgfb1 18 0.43 14.27 5.16
141 INT351278 Regulation of FMOD 1 0.09 6.45 5.16
142 INT84561 Binding of COL1A2 18 0.47 11.76 5.09
143 INT19187 Gene_expression of Lgals3 24 0.73 19.72 5.03
144 INT15941 Negative_regulation of Serpine1 42 0.58 21.07 4.95
145 INT112883 Gene_expression of Hspg2 22 0.65 6.54 4.95
146 INT1285 Localization of Mmp13 12 0.78 8.98 4.93
147 INT51839 Positive_regulation of Localization of PLAT 5 0.49 7.09 4.92
148 INT15920 Regulation of Serpine1 34 0.42 17.36 4.89
149 INT17312 Binding of HSPG2 30 0.41 33.01 4.88
150 INT328620 Phosphorylation of Cfp 8 0.39 5.05 4.87
151 INT185877 Negative_regulation of Gene_expression of DCN 3 0.33 2.37 4.85
152 INT53194 Negative_regulation of Positive_regulation of Cfp 10 0.45 4.87 4.78
153 INT69215 Gene_expression of Col1a1 38 0.68 17.39 4.77
154 INT137332 Positive_regulation of Gene_expression of Sod1 41 0.70 19.8 4.69
155 INT79194 Positive_regulation of Tnc 5 0.41 2.25 4.69
156 INT124375 Gene_expression of Wnt2 67 0.56 38.03 4.67
157 INT74447 Gene_expression of Vwf 39 0.76 21.96 4.66
158 INT89791 Transcription of Mmp3 7 0.33 2.28 4.64
159 INT14831 Negative_regulation of TNC 18 0.50 8.71 4.61
160 INT210885 Regulation of SLPI 8 0.44 7.15 4.61
161 INT220861 Positive_regulation of Mmp8 14 0.50 12.21 4.6
162 INT37168 Positive_regulation of APCS 22 0.67 9.61 4.59
163 INT12324 Positive_regulation of PRTN3 26 0.70 18.82 4.55
164 INT115927 Negative_regulation of Hspg2 27 0.57 4.16 4.53
165 INT160914 Positive_regulation of Positive_regulation of Mmp9 7 0.57 4.69 4.52
166 INT85301 Gene_expression of Ndp 6 0.52 4.19 4.5
167 INT107605 Gene_expression of MMP14 26 0.64 25.88 4.49
168 INT250981 Gene_expression of FMOD 2 0.20 7.3 4.47
169 INT125005 Negative_regulation of SLPI 9 0.42 5.79 4.43
170 INT68369 Transcription of TNC 13 0.72 8.69 4.42
171 INT11354 Regulation of Gene_expression of SERPINE1 11 0.61 8.66 4.42
172 INT19965 Positive_regulation of COL1A1 23 0.45 14.49 4.38
173 INT83818 Positive_regulation of Localization of Cfp 5 0.32 3.6 4.33
174 INT22973 Gene_expression of Col3a1 22 0.42 15.85 4.32
175 INT134968 Localization of Ecm1 20 0.32 27.27 4.31
176 INT67279 Localization of PRTN3 11 0.50 14.18 4.3
177 INT107771 Localization of HSPG2 10 0.78 8.47 4.3
178 INT11635 Positive_regulation of Gene_expression of SERPINE1 35 0.68 24.57 4.26
179 INT11634 Regulation of SERPINE1 24 0.62 20.06 4.26
180 INT129964 Negative_regulation of MMP13 23 0.55 6.48 4.21
181 INT57273 Positive_regulation of Gene_expression of FN1 26 0.47 17.83 4.2
182 INT113485 Localization of MMP14 11 0.77 3.44 4.19
183 INT125896 Negative_regulation of Gene_expression of Mmp9 15 0.43 13.73 4.18
184 INT36335 Localization of Tgfb1 19 0.79 7.06 4.17
185 INT12915 Gene_expression of MGP 18 0.75 7.53 4.15
186 INT97334 Positive_regulation of Gene_expression of Timp1 11 0.49 7.44 4.14
187 INT32053 Positive_regulation of Gene_expression of Tnc 5 0.45 3.4 4.13
188 INT55741 Negative_regulation of Timp1 15 0.51 8.12 4.09
189 INT160915 Regulation of Mmp9 16 0.35 10.25 4.07
190 INT69681 Negative_regulation of Tgfb1 42 0.51 22.28 4
191 INT68789 Regulation of CFP 17 0.51 4.76 3.98
192 INT220047 Negative_regulation of Gene_expression of Mmp3 4 0.29 5.93 3.95
193 INT17548 Negative_regulation of Serpine1 30 0.57 24.69 3.93
194 INT124815 Binding of Col2a1 9 0.37 10.27 3.93
195 INT189629 Negative_regulation of TIMP3 14 0.48 7.63 3.91
196 INT7437 Gene_expression of CFP 21 0.65 4.93 3.89
197 INT15724 Negative_regulation of Fn1 15 0.53 5.61 3.87
198 INT140186 Positive_regulation of Gene_expression of Mmp3 7 0.55 6.04 3.82
199 INT86293 Positive_regulation of Gene_expression of Mmp2 21 0.64 11.69 3.79
200 INT78493 Negative_regulation of F3 11 0.27 8.35 3.76
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