GO:0031016

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Name pancreas development
Categary Process
Go Slim No
Go Link GO:0031016
Unique Molecular Interactions 284
Total Molecular Interactions 355
Total Single Events 2613
Pain Genes Associated 37

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for pancreas development. They are ordered first by their pain relevance and then by number of times they were reported for pancreas development. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT37162 Binding of Calca and Cckar 1 0.04 0.55 3.01
2 INT150682 Pomc Regulation of Gene_expression of Eif2ak3 1 0.37 0.17 1.44
3 INT84886 APC Regulation of PPARD 1 0.51 1.57 1.26
4 INT274948 Binding of Dh and Ltp 1 0.11 0.55 1.23
5 INT161769 Cck Regulation of Cckar 1 0.27 0.53 0.92
6 INT101259 Gata6 Negative_regulation of Gene_expression of ALOX15 1 0.42 0.67 0.89
7 INT101258 Gene_expression of Gata6 Negative_regulation of Positive_regulation of ALOX15 1 0.42 0.65 0.87
8 INT140985 Gli3 Regulation of Ihh 1 0.29 0.85 0.85
9 INT150680 Pomc Negative_regulation of Gene_expression of Eif2ak3 1 0.35 0.07 0.8
10 INT195778 Binding of APC and PROCR 7 0.19 3.78 0.73
11 INT149899 Ihh Positive_regulation of Mmp7 1 0.04 1.69 0.65
12 INT333476 IL12B Positive_regulation of Localization of AFP 1 0.03 0.26 0.57
13 INT182150 Binding of APC and DCPS 1 0.02 1.14 0.48
14 INT173475 Bcar1 Regulation of Isl1 1 0.01 0 0.47
15 INT149894 Ihh Positive_regulation of Localization of Mmp14 1 0.04 2.06 0.47
16 INT335850 Snrpc Negative_regulation of Gene_expression of Isl1 1 0.00 1.51 0.45
17 INT113040 IHH Regulation of Gene_expression of INS 1 0.12 0.37 0.37
18 INT300609 Binding of Ctnnb1 and Wnt2 1 0.02 0.25 0.37
19 INT84887 APC Negative_regulation of Gene_expression of PPARD 1 0.36 0.55 0.37
20 INT124378 Prodh2 Positive_regulation of Ctnnb1 1 0.00 0.59 0.35
21 INT149897 Ihh Positive_regulation of Mmp14 1 0.03 0.93 0.33
22 INT149896 Ihh Regulation of Gene_expression of Col1a1 1 0.06 0.89 0.33
23 INT149895 Ihh Regulation of Localization of Mmp7 1 0.03 0.98 0.33
24 INT149902 Ihh Positive_regulation of SGCG 1 0.45 0.76 0.32
25 INT195665 APC Negative_regulation of F8 1 0.04 1.53 0.32
26 INT195664 APC Negative_regulation of F5 1 0.08 1.51 0.31
27 INT168948 Binding of CCK and CCKAR 1 0.23 0 0.3
28 INT309369 Ptf1a Positive_regulation of Pax2 1 0.10 0 0.3
29 INT63122 Binding of APC and Man2a2 1 0.01 0.15 0.3
30 INT118239 Binding of CCKAR and CYP2B6 1 0.32 0.19 0.29
31 INT137023 Gene_expression of SMAD2 Negative_regulation of Gene_expression of Acta2 1 0.00 0.43 0.29
32 INT289954 Binding of APC and CD28 1 0.03 0.38 0.28
33 INT149898 Ihh Regulation of Localization of Mmp14 1 0.03 1.29 0.27
34 INT235976 Binding of APC and Trav6-3 2 0.01 2.62 0.24
35 INT235974 Negative_regulation of Binding of APC and Trav6-3 1 0.00 1.15 0.24
36 INT235972 Negative_regulation of Binding of APC and Bcr 1 0.01 1.15 0.24
37 INT235973 Binding of APC and Bcr 1 0.01 1.14 0.24
38 INT210798 Ihh Positive_regulation of Itgbl1 1 0.34 0 0.23
39 INT109408 Negative_regulation of APC Negative_regulation of Positive_regulation of RASGRP1 1 0.06 0.73 0.23
40 INT250783 APC Negative_regulation of SERPINE1 1 0.06 0.86 0.23
41 INT260835 NRP2 Positive_regulation of Eif2ak3 1 0.00 0.73 0.23
42 INT250782 APC Negative_regulation of F2 1 0.00 0.86 0.23
43 INT316111 APC Negative_regulation of SAE1 1 0.04 1.21 0.22
44 INT195663 APC Negative_regulation of Gene_expression of IL6 1 0.16 1.18 0.22
45 INT297545 Pou3f3 Regulation of Hes1 1 0.05 0.41 0.2
46 INT316110 Binding of APC and SAE1 1 0.03 1.16 0.2
47 INT236338 Negative_regulation of Binding of PCSK1 and GOPC 1 0.06 0.19 0.2
48 INT256629 Binding of Ptch1 and Shh 7 0.42 4.22 0.19
49 INT245183 Binding of CTSB and TCF7L2 1 0.39 6.39 0.18
50 INT333449 Binding of SMAD2 and SMAD4 1 0.23 0 0.17
51 INT210795 Ihh Negative_regulation of Itgb1 1 0.30 0 0.17
52 INT334106 APC Negative_regulation of NFKB1 1 0.25 1.37 0.17
53 INT334108 APC Negative_regulation of TNF 1 0.13 1.36 0.17
54 INT299725 AFP Positive_regulation of Positive_regulation of ACPP 1 0.00 0.78 0.17
55 INT236339 Binding of PCSK1 and GOPC 1 0.05 0.14 0.17
56 INT333447 Binding of SMAD2 and RXRA 1 0.04 0 0.16
57 INT210782 Ihh Negative_regulation of Itgbl1 1 0.31 0 0.16
58 INT210804 Ihh Negative_regulation of Timp4 1 0.32 0 0.16
59 INT116124 Binding of AFP and HCC 2 0.20 1.72 0.15
60 INT72116 Binding of PCSK1 and POMC 1 0.32 0 0.15
61 INT257937 Binding of CSF2 and INVS 1 0.04 1.1 0.14
62 INT355867 Binding of Afp and HCC 1 0.01 2.25 0.14
63 INT289956 Binding of APC and ICAM1 1 0.04 0.5 0.13
64 INT251115 Positive_regulation of Binding of AR and Ctnnb1 1 0.01 1.02 0.13
65 INT184603 APC Negative_regulation of Gene_expression of TNF 1 0.09 0.97 0.13
66 INT184608 APC Regulation of Gene_expression of Nppa 1 0.06 1.11 0.12
67 INT251114 Binding of AR and Ctnnb1 1 0.01 1 0.12
68 INT299754 Binding of APC and CTLA4 2 0.08 0.97 0.11
69 INT245185 Binding of RRAD and TCF7L2 1 0.00 6.88 0.1
70 INT316823 Sparc Positive_regulation of Phosphorylation of Smad2 1 0.44 0.49 0.1
71 INT297548 Neurod1 Regulation of Hes1 1 0.05 0.2 0.1
72 INT245182 Binding of SPINK1 and TCF7L2 1 0.39 2.05 0.1
73 INT262255 Binding of APC and F2R 1 0.05 3 0.1
74 INT139250 CCKAR Positive_regulation of Localization of POMC 1 0.35 0.61 0.09
75 INT41574 POMC Regulation of CCKAR 1 0.00 0 0.09
76 INT165161 Ihh Positive_regulation of Sostdc1 1 0.58 0.07 0.09
77 INT165160 Regulation of Ihh Positive_regulation of Sostdc1 1 0.23 0.07 0.09
78 INT41514 Oxt Regulation of AFP 1 0.16 0.09 0.09
79 INT165158 Positive_regulation of Ihh Positive_regulation of Sostdc1 1 0.42 0.07 0.09
80 INT215884 Eif2ak3 Positive_regulation of Gene_expression of Musd1 1 0.01 0.96 0.09
81 INT210788 Ihh Negative_regulation of Coro1a 1 0.02 0 0.08
82 INT213418 Negative_regulation of FOXF1 Negative_regulation of Gene_expression of VCAM1 1 0.29 0.15 0.08
83 INT270464 Binding of Shh and Smo 1 0.07 1.3 0.08
84 INT210790 Ihh Negative_regulation of Cdkn1c 1 0.30 0 0.08
85 INT290906 Shh Positive_regulation of Egfr 1 0.23 0 0.08
86 INT210787 Ihh Negative_regulation of Nr3c1 1 0.33 0 0.08
87 INT213419 Negative_regulation of FOXF1 Negative_regulation of Gene_expression of HGF 1 0.25 0.15 0.08
88 INT212071 Eno2 Regulation of Localization of Afp 1 0.01 0.52 0.07
89 INT212079 SYP Regulation of Localization of Afp 1 0.10 0.52 0.07
90 INT212077 CHGA Regulation of Localization of Afp 1 0.10 0.52 0.07
91 INT212070 ENO2 Regulation of Localization of AFP 1 0.49 0.52 0.07
92 INT298349 HES3 Positive_regulation of Shh 1 0.12 0.14 0.07
93 INT212076 ENO2 Regulation of Localization of Afp 1 0.10 0.52 0.07
94 INT215874 Positive_regulation of Eif2ak3 Positive_regulation of Positive_regulation of Ddit3 1 0.47 0.31 0.07
95 INT212067 CHGA Regulation of Localization of AFP 1 0.49 0.52 0.07
96 INT212081 Eno2 Regulation of Localization of AFP 1 0.03 0.52 0.07
97 INT212062 SYP Regulation of Localization of AFP 1 0.49 0.52 0.07
98 INT303562 Binding of Fgf10 and Fgfr2 1 0.40 0.88 0.07
99 INT290905 Gene_expression of Shh Positive_regulation of Gene_expression of Angpt1 1 0.14 0 0.06
100 INT215883 Eif2ak3 Regulation of Musd1 1 0.00 0.8 0.06
101 INT215878 Eif2ak3 Positive_regulation of Localization of Ins1 1 0.04 0.96 0.06
102 INT215877 Atf4 Regulation of Eif2ak3 1 0.44 0.21 0.06
103 INT215873 Ddit3 Regulation of Eif2ak3 1 0.39 0.2 0.06
104 INT339110 ERBB2 Positive_regulation of GATA6 1 0.31 0.67 0.06
105 INT353284 Prdx2 Negative_regulation of Gene_expression of Smad2 1 0.16 0.07 0.05
106 INT287223 Pdx1 Regulation of Transcription of Insig1 1 0.03 0.56 0.05
107 INT355439 Pdia3 Regulation of Gene_expression of Eif2ak3 1 0.01 0.83 0.05
108 INT334107 Binding of APC and APCS 1 0.16 1.52 0.04
109 INT133983 Pou2f1 Regulation of Pdx1 1 0.06 0 0.04
110 INT133989 Pdx1 Regulation of Kcnip3 1 0.07 0 0.04
111 INT133981 Pdx1 Regulation of Pou1f1 1 0.05 0 0.04
112 INT5608 Gnl3 Regulation of Eif2ak3 1 0.05 0 0.04
113 INT133982 Pou1f1 Regulation of Pdx1 1 0.05 0 0.04
114 INT353290 Binding of Smad2 and Smad4 1 0.20 0.08 0.04
115 INT353294 Binding of Smad2 and Smad3 1 0.15 0.08 0.04
116 INT133990 Meis1 Regulation of Pdx1 1 0.05 0 0.04
117 INT134000 Pdx1 Regulation of Gene_expression of Npff 1 0.46 0 0.04
118 INT213563 Binding of Ctnnd2 and Shh 1 0.27 0.09 0.04
119 INT133978 Pdx1 Regulation of Pou2f1 1 0.06 0 0.04
120 INT353289 Prdx2 Negative_regulation of Positive_regulation of Smad2 1 0.18 0.17 0.04
121 INT353293 Prdx2 Negative_regulation of Localization of Smad2 1 0.16 0 0.04
122 INT270459 Binding of Shh and Gli1 1 0.02 0.65 0.04
123 INT134001 Kcnip3 Regulation of Pdx1 1 0.07 0 0.04
124 INT133996 Pdx1 Regulation of Meis1 1 0.05 0 0.04
125 INT311904 Smad2 Positive_regulation of Gene_expression of Smad1 1 0.13 0.44 0.03
126 INT319218 Bmpr2 Negative_regulation of Smad2 1 0.17 0.12 0.03
127 INT352014 Shh Positive_regulation of Gene_expression of Pax1 1 0.29 0.07 0.03
128 INT353286 Prdx2 Positive_regulation of Phosphorylation of Smad2 1 0.24 0.06 0.03
129 INT303563 Binding of Fgf10 and Dysf 1 0.00 0.44 0.03
130 INT256707 Eif2ak3 Regulation of Gene_expression of Wfs1 1 0.10 0.78 0.03
131 INT311655 Shh Positive_regulation of Gene_expression of Fgf8 1 0.31 0.18 0.03
132 INT270462 Shh Positive_regulation of Ccnd1 1 0.10 0.6 0.03
133 INT213559 Binding of Egf and Shh 1 0.17 0.07 0.03
134 INT314869 Binding of Gdf11 and Tgfbr3 1 0.29 0.14 0
135 INT244856 Lbx1 Regulation of Isl1 1 0.60 0 0
136 INT290910 Pkm2 Negative_regulation of Shh 1 0.07 0.06 0
137 INT269915 Binding of Smad2 and Sox17 1 0.21 0.07 0
138 INT205963 GLI1 Positive_regulation of Negative_regulation of SHH 1 0.22 0.58 0
139 INT355603 Binding of CTNNA1 and Ctnnb1 1 0.00 1.07 0
140 INT314850 Shh Regulation of Atoh7 1 0.45 0.22 0
141 INT269944 Gata6 Regulation of Gene_expression of Foxj1 1 0.19 0 0
142 INT220818 Binding of Ctnnb1 and Myc 1 0.06 0.13 0
143 INT290908 Regulation of Shh Positive_regulation of Ntn1 1 0.12 0 0
144 INT264735 Binding of Hes1 and Mir199b 1 0.08 0.93 0
145 INT314858 Binding of Gdf11 and Ltbp3 1 0.39 0.31 0
146 INT218669 Olr811 Negative_regulation of Phosphorylation of Smad2 1 0.01 0.18 0
147 INT314854 Gdf11 Regulation of Atoh7 1 0.51 0.21 0
148 INT286566 Binding of Ctnnb1 and Cdh6 1 0.00 1 0
149 INT290911 Gene_expression of Shh Positive_regulation of Pkm2 1 0.07 0 0
150 INT264738 Mir199b Regulation of Gene_expression of Hes1 1 0.08 0.89 0
151 INT337915 Tgfbr1 Positive_regulation of Negative_regulation of Smad2 1 0.05 0.15 0
152 INT286562 Gene_expression of Pkd1 Positive_regulation of Ctnnb1 1 0.02 0.52 0
153 INT290904 Shh Positive_regulation of Prkcg 1 0.26 0.06 0
154 INT290900 Prkcg Regulation of Shh 1 0.23 0 0
155 INT136693 Gtf3a Positive_regulation of Ctnnb1 1 0.05 0 0
156 INT314773 Glp1r Positive_regulation of Gene_expression of Pdx1 1 0.01 0.57 0
157 INT314855 Binding of Gdf11 and Atoh7 1 0.40 0.14 0
158 INT197794 Negative_regulation of Pthlh Regulation of Ihh 1 0.36 1.33 0
159 INT243467 PCSK1 Positive_regulation of POMC 1 0.08 1.62 0
160 INT301675 Binding of APC and HLA-E 1 0.01 1.48 0
161 INT264736 Hes1 Regulation of Notch2 1 0.20 0.13 0
162 INT172838 Binding of ISL1 and T2dm2 1 0.00 2.41 0
163 INT205960 Binding of PTCH1 and SHH 1 0.21 0.71 0
164 INT290944 Shh Positive_regulation of VEGFA 1 0.04 0.05 0
165 INT205387 Binding of PCSK1 and DCLK1 1 0.05 1.42 0
166 INT49943 Binding of Th and Pdx1 1 0.02 0.17 0
167 INT270461 Shh Regulation of Gene_expression of Ptch1 1 0.48 0.07 0
168 INT197316 Hes1 Regulation of Atoh1 1 0.01 0.14 0
169 INT203853 Eif2ak3 Positive_regulation of Eif2ak1 1 0.05 0.63 0
170 INT269936 Smad2 Positive_regulation of Cdkn2b 1 0.15 0.07 0
171 INT323254 Binding of Ptprv and Isl1 1 0.00 0.6 0
172 INT244860 Lbx1 Negative_regulation of Isl1 1 0.16 0 0
173 INT265233 Binding of APC and FKBP1A 1 0.08 0.41 0
174 INT268341 SMAD2 Positive_regulation of SMAD4 1 0.31 0.56 0
175 INT217780 MIR181A1 Regulation of GATA6 1 0.17 0.7 0
176 INT301674 Binding of APC and CD80 1 0.01 0.53 0
177 INT205959 Binding of SHH and SMOX 1 0.12 0.72 0
178 INT337914 sb Negative_regulation of Phosphorylation of Smad2 1 0.00 0.13 0
179 INT197304 Ahr Regulation of Hes1 1 0.06 0.17 0
180 INT220821 Binding of MAX and Ctnnb1 1 0.09 0.13 0
181 INT326118 Binding of BMI1 and PCSK1 1 0.09 0 0
182 INT195661 Binding of APC and PROC 1 0.23 0.89 0
183 INT314861 Gdf11 Regulation of Gene_expression of Atoh7 1 0.20 0.26 0
184 INT264731 Gene_expression of Hes1 Negative_regulation of Positive_regulation of Musd1 1 0.00 0.18 0
185 INT253019 APC Positive_regulation of Protein_catabolism of Pttg1 1 0.06 0 0
186 INT253012 APC Positive_regulation of Binding of Pttg1 1 0.06 0 0
187 INT323253 Binding of Ins1 and Isl1 1 0.00 0.59 0
188 INT268342 Binding of APC and ANKS1B 1 0.01 0.92 0
189 INT270471 Shh Regulation of VEGFA 1 0.39 0.08 0
190 INT301677 Binding of APC and CD8A 1 0.03 1.48 0
191 INT290898 Shh Positive_regulation of Nos2 1 0.46 0.05 0
192 INT286561 Binding of Ctnnb1 and Cdh2 1 0.00 1.06 0
193 INT295571 Binding of Acvr2b and Mstn 1 0.08 0 0
194 INT265232 Regulation of Binding of APC and FKBP1A 1 0.08 0.41 0
195 INT355864 EXT1 Positive_regulation of Positive_regulation of Afp 1 0.05 0.93 0
196 INT202675 Fgf10 Positive_regulation of Fgfr2 1 0.45 0.07 0
197 INT313840 Binding of Acvr2b and Mstn 1 0.02 0.07 0
198 INT205392 Binding of ANPEP and PCSK1 1 0.06 1.4 0
199 INT245193 Binding of TCF7L2 and Abpa 1 0.02 10.66 0
200 INT268395 Binding of APC and Kras 1 0.04 1.21 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for pancreas development. They are ordered first by their pain relevance and then by number of times they were reported in pancreas development. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT109031 Positive_regulation of Eif2ak3 44 0.69 21.11 14.72
2 INT109034 Gene_expression of Eif2ak3 37 0.77 17.11 14.19
3 INT6510 Gene_expression of AFP 130 0.78 119.2 9.19
4 INT150678 Positive_regulation of Gene_expression of Eif2ak3 17 0.69 6.64 8.99
5 INT57057 Gene_expression of APC 131 0.78 122.24 8.7
6 INT65803 Gene_expression of Dh 10 0.32 1.24 8.07
7 INT8669 Positive_regulation of Afp 66 0.70 58.21 7.67
8 INT6511 Positive_regulation of AFP 76 0.70 70.15 7.28
9 INT16631 Negative_regulation of APC 46 0.57 30.53 7.11
10 INT36757 Gene_expression of Eif2ak3 4 0.74 0.15 6.06
11 INT127112 Phosphorylation of Smad2 19 0.80 11.01 5.36
12 INT23725 Gene_expression of CCKAR 14 0.55 0.14 5.3
13 INT57064 Positive_regulation of APC 72 0.66 48.5 5.08
14 INT54002 Negative_regulation of Dh 6 0.20 3.05 5.06
15 INT137336 Phosphorylation of Eif2ak3 14 0.79 4.72 4.78
16 INT203443 Gene_expression of Isl1 27 0.67 11.12 4.65
17 INT57642 Gene_expression of PCSK1 26 0.76 5.09 4.28
18 INT745 Gene_expression of Afp 65 0.78 52.89 4.24
19 INT5602 Positive_regulation of Eif2ak3 9 0.66 0 4.04
20 INT63121 Binding of APC 29 0.41 23.02 3.8
21 INT23728 Negative_regulation of CCKAR 6 0.42 0.48 3.53
22 INT8477 Negative_regulation of AFP 35 0.58 31.52 3.1
23 INT101567 Gene_expression of Ctnnb1 7 0.64 10.11 2.89
24 INT8670 Negative_regulation of Afp 27 0.58 19.85 2.87
25 INT113041 Gene_expression of IHH 9 0.78 5.83 2.87
26 INT132773 Negative_regulation of Acvr2b 3 0.41 1.55 2.87
27 INT85947 Regulation of Cckar 2 0.36 2.4 2.86
28 INT101246 Gene_expression of Gata6 6 0.68 3.03 2.68
29 INT203819 Binding of Eif2ak3 9 0.37 5.94 2.57
30 INT23534 Regulation of CCKAR 8 0.32 0.17 2.56
31 INT127113 Positive_regulation of Phosphorylation of Smad2 1 0.68 2.38 2.51
32 INT40505 Positive_regulation of CCKAR 3 0.40 0 2.42
33 INT194504 Gene_expression of Smad2 27 0.65 7.45 2.25
34 INT121543 Positive_regulation of Gene_expression of PCSK1 4 0.29 1.63 2.21
35 INT36758 Positive_regulation of Gene_expression of Eif2ak3 1 0.48 0 2.21
36 INT81641 Gene_expression of Ctnnb1 23 0.72 14.93 1.97
37 INT36755 Positive_regulation of Localization of Eif2ak3 1 0.48 0 1.97
38 INT144973 Gene_expression of Shh 9 0.77 4.32 1.96
39 INT36756 Localization of Eif2ak3 1 0.71 0 1.96
40 INT150675 Regulation of Gene_expression of Eif2ak3 3 0.40 1.11 1.93
41 INT30373 Localization of CCKAR 5 0.68 0.17 1.79
42 INT208561 Gene_expression of Shh 51 0.78 9.57 1.77
43 INT101252 Negative_regulation of Gene_expression of Gata6 1 0.51 1.3 1.74
44 INT36759 Regulation of Gene_expression of Eif2ak3 1 0.59 0 1.74
45 INT101244 Regulation of Gata6 3 0.40 1.52 1.7
46 INT123990 Positive_regulation of Ctnnb1 8 0.43 2.85 1.63
47 INT99391 Localization of Ctnnb1 7 0.80 5.84 1.61
48 INT109033 Positive_regulation of Positive_regulation of Eif2ak3 2 0.45 2.36 1.59
49 INT127115 Regulation of Phosphorylation of Smad2 1 0.60 1.74 1.53
50 INT14971 Regulation of Afp 12 0.44 11.35 1.48
51 INT150677 Negative_regulation of Eif2ak3 9 0.58 6.24 1.46
52 INT255251 Negative_regulation of Smad2 12 0.32 5.69 1.44
53 INT54775 Binding of Cckar 1 0.34 0 1.43
54 INT215864 Localization of Eif2ak3 5 0.75 3.26 1.36
55 INT18337 Transcription of Eif2ak3 3 0.68 0 1.36
56 INT168954 Binding of CCKAR 1 0.28 0 1.36
57 INT129619 Phosphorylation of Smad2 34 0.61 11.6 1.34
58 INT23727 Positive_regulation of Gene_expression of CCKAR 4 0.31 0 1.34
59 INT160606 Localization of AFP 6 0.74 3.39 1.29
60 INT99389 Negative_regulation of Ctnnb1 8 0.45 3.97 1.21
61 INT200838 Positive_regulation of Isl1 6 0.60 0.73 1.19
62 INT140983 Gene_expression of Ihh 7 0.78 2.06 1.15
63 INT102073 Regulation of Gene_expression of APC 5 0.45 6.09 1.15
64 INT253191 Positive_regulation of Gene_expression of Shh 2 0.66 2.57 1.14
65 INT172809 Gene_expression of ISL1 33 0.40 21.63 1.12
66 INT102074 Positive_regulation of Gene_expression of APC 20 0.50 13.66 1.1
67 INT97695 Positive_regulation of Dh 3 0.33 1.44 1.1
68 INT137338 Regulation of Eif2ak3 8 0.45 5.5 1.07
69 INT101570 Positive_regulation of Gene_expression of Ctnnb1 1 0.58 5.7 1.07
70 INT165530 Positive_regulation of Shh 4 0.69 1.21 1.05
71 INT88032 Negative_regulation of PCSK1 4 0.32 1.27 0.92
72 INT218696 Negative_regulation of Phosphorylation of Smad2 3 0.42 4.36 0.92
73 INT72944 Positive_regulation of PCSK1 3 0.49 0 0.89
74 INT101566 Negative_regulation of Gene_expression of Ctnnb1 1 0.35 2.28 0.88
75 INT165345 Localization of PCSK1 2 0.48 0.39 0.87
76 INT240368 Positive_regulation of Localization of Eif2ak3 1 0.34 0.66 0.87
77 INT39357 Binding of Afp 5 0.48 3.58 0.85
78 INT109032 Negative_regulation of Positive_regulation of Eif2ak3 1 0.38 0.94 0.85
79 INT101248 Negative_regulation of Gata6 1 0.37 0.83 0.85
80 INT101251 Negative_regulation of Positive_regulation of Gata6 1 0.38 0.83 0.85
81 INT101250 Positive_regulation of Gata6 1 0.41 0.83 0.84
82 INT173472 Positive_regulation of Isl1 1 0.03 0.2 0.83
83 INT101245 Transcription of Gata6 2 0.47 0.85 0.82
84 INT23726 Positive_regulation of Negative_regulation of CCKAR 1 0.08 0 0.82
85 INT66061 Positive_regulation of Gene_expression of AFP 6 0.70 8.67 0.81
86 INT267095 Regulation of Gene_expression of Smad2 3 0.44 1.77 0.8
87 INT154053 Negative_regulation of Gene_expression of Eif2ak3 2 0.43 1.28 0.79
88 INT137007 Gene_expression of SMAD2 6 0.75 2.53 0.75
89 INT23953 Gene_expression of Cckar 3 0.65 0.2 0.74
90 INT265318 Negative_regulation of Gene_expression of Smad2 8 0.26 2.16 0.72
91 INT105947 Binding of Dh 3 0.35 0.79 0.72
92 INT57062 Regulation of APC 24 0.58 14.3 0.7
93 INT41928 Binding of AFP 9 0.36 7.85 0.7
94 INT80674 Negative_regulation of Gene_expression of APC 16 0.59 18.14 0.69
95 INT269896 Positive_regulation of Gene_expression of Smad2 9 0.40 2.15 0.69
96 INT14973 Regulation of Gene_expression of AFP 3 0.44 4.16 0.69
97 INT243779 Negative_regulation of Gene_expression of Isl1 2 0.30 2.62 0.68
98 INT137009 Negative_regulation of Gene_expression of SMAD2 4 0.42 1.76 0.66
99 INT268377 Phosphorylation of SMAD2 7 0.80 0.85 0.65
100 INT99390 Regulation of Ctnnb1 4 0.62 3.12 0.64
101 INT302664 Positive_regulation of SMAD2 2 0.49 0.85 0.64
102 INT264709 Gene_expression of Hes1 24 0.76 7.04 0.63
103 INT168965 Negative_regulation of Binding of CCKAR 1 0.22 0 0.63
104 INT168966 Positive_regulation of Localization of CCKAR 1 0.29 0 0.62
105 INT25006 Negative_regulation of Gene_expression of CCKAR 1 0.30 0 0.62
106 INT113042 Localization of IHH 1 0.70 0.77 0.61
107 INT226838 Transcription of Isl1 2 0.28 0.36 0.6
108 INT200797 Positive_regulation of Ptprv 4 0.14 3.19 0.58
109 INT296583 Gene_expression of Fgf10 3 0.59 2.64 0.57
110 INT140984 Regulation of Ihh 5 0.54 2.81 0.56
111 INT296594 Regulation of Fgf10 1 0.15 1.53 0.56
112 INT133968 Binding of Pdx1 1 0.32 0.16 0.55
113 INT72869 Regulation of Negative_regulation of APC 2 0.36 1.7 0.54
114 INT62101 Protein_catabolism of CCKAR 1 0.01 0 0.54
115 INT76960 Negative_regulation of Ctnnb1 5 0.57 3.46 0.53
116 INT5601 Regulation of Eif2ak3 1 0.43 0 0.53
117 INT15046 Positive_regulation of Gene_expression of Afp 6 0.46 5.95 0.52
118 INT24029 Regulation of AFP 7 0.44 6.45 0.51
119 INT158889 Gene_expression of Smad2 5 0.65 1.25 0.51
120 INT39113 Negative_regulation of Cckar 2 0.41 0.28 0.5
121 INT125381 Regulation of Dh 3 0.29 1.07 0.49
122 INT18336 Positive_regulation of Positive_regulation of Eif2ak3 1 0.33 0 0.49
123 INT81645 Positive_regulation of Gene_expression of Ctnnb1 6 0.63 3.78 0.47
124 INT14972 Regulation of Gene_expression of Afp 2 0.45 1.1 0.47
125 INT206484 Localization of Shh 2 0.75 1.14 0.46
126 INT218293 Gene_expression of Acvr2b 14 0.76 4.22 0.44
127 INT232798 Positive_regulation of Gene_expression of Shh 7 0.70 1.49 0.44
128 INT228298 Gene_expression of INVS 10 0.65 6.44 0.43
129 INT76958 Positive_regulation of Ctnnb1 14 0.64 5.48 0.41
130 INT95872 Localization of Ctnnb1 7 0.74 2.75 0.4
131 INT208559 Negative_regulation of Gene_expression of Shh 8 0.43 1.58 0.38
132 INT81644 Regulation of Ctnnb1 5 0.41 3.38 0.37
133 INT81643 Regulation of Gene_expression of Ctnnb1 3 0.57 1.5 0.37
134 INT17937 Gene_expression of Isl1 4 0.27 0.48 0.36
135 INT218901 Negative_regulation of Ptprv 1 0.02 1.73 0.36
136 INT118243 Transcription of APC 4 0.45 3.33 0.33
137 INT166716 Negative_regulation of Ihh 3 0.43 0.67 0.33
138 INT184605 Positive_regulation of Transcription of APC 2 0.19 2.39 0.33
139 INT156399 Regulation of Pdx1 1 0.00 0.96 0.33
140 INT108324 Negative_regulation of Gene_expression of Ctnnb1 1 0.06 1.43 0.31
141 INT195672 Localization of APC 7 0.74 3.76 0.3
142 INT129908 Positive_regulation of Smad2 5 0.45 2.13 0.3
143 INT137008 Positive_regulation of Gene_expression of SMAD2 2 0.49 0.51 0.3
144 INT202646 Gene_expression of Ptf1a 10 0.48 0.46 0.29
145 INT172806 Localization of ISL1 4 0.26 2.64 0.29
146 INT224877 Positive_regulation of Gene_expression of Smad2 1 0.12 0.16 0.29
147 INT172978 Negative_regulation of SMAD2 4 0.42 0.89 0.27
148 INT111124 Positive_regulation of INVS 3 0.49 0.73 0.27
149 INT78132 Binding of Isl1 1 0.16 0 0.27
150 INT25465 Positive_regulation of ISL1 6 0.15 3.59 0.26
151 INT49942 Positive_regulation of Pdx1 5 0.02 1.24 0.26
152 INT173797 Negative_regulation of Isl1 3 0.37 0.15 0.26
153 INT232795 Positive_regulation of Shh 2 0.70 3.68 0.26
154 INT149893 Positive_regulation of Gene_expression of Ihh 1 0.69 0.62 0.26
155 INT173792 Negative_regulation of Negative_regulation of Isl1 1 0.08 0.15 0.26
156 INT149892 Gene_expression of Ihh 1 0.77 0.61 0.26
157 INT332230 Regulation of Pdx1 1 0.01 0.99 0.25
158 INT151719 Negative_regulation of Positive_regulation of Ctnnb1 1 0.23 1.9 0.24
159 INT202632 Negative_regulation of Ptf1a 2 0.27 0 0.23
160 INT129907 Regulation of Smad2 1 0.40 0.87 0.23
161 INT309358 Positive_regulation of Ptf1a 1 0.17 0 0.23
162 INT309357 Negative_regulation of Positive_regulation of Ptf1a 1 0.14 0 0.23
163 INT140639 Gene_expression of FOXF1 3 0.52 0.89 0.22
164 INT30371 Regulation of Localization of CCKAR 1 0.18 0.17 0.22
165 INT183062 Gene_expression of SHH 12 0.65 5.28 0.21
166 INT265311 Localization of Smad2 5 0.50 1.57 0.21
167 INT265334 Regulation of Phosphorylation of Smad2 2 0.17 0.96 0.2
168 INT134477 Negative_regulation of SHH 2 0.37 1.13 0.2
169 INT149888 Localization of Ihh 1 0.75 0.77 0.2
170 INT205087 Positive_regulation of Gene_expression of ISL1 4 0.26 3.86 0.19
171 INT173166 Negative_regulation of Binding of APC 3 0.40 3.01 0.19
172 INT8478 Negative_regulation of Gene_expression of AFP 3 0.42 2.37 0.19
173 INT355487 Positive_regulation of Regulation of Afp 1 0.04 1.19 0.19
174 INT243778 Binding of Isl1 1 0.26 0 0.19
175 INT50950 Localization of Afp 9 0.50 5.04 0.18
176 INT264701 Negative_regulation of Gene_expression of Hes1 1 0.42 0.73 0.18
177 INT10042 Protein_catabolism of Cckar 1 0.08 0 0.18
178 INT57065 Negative_regulation of Positive_regulation of APC 3 0.22 2.43 0.17
179 INT76880 Localization of Cckar 2 0.07 0.08 0.17
180 INT268365 Binding of SMAD2 2 0.47 0.56 0.17
181 INT99392 Negative_regulation of Localization of Ctnnb1 2 0.59 1.43 0.17
182 INT151721 Negative_regulation of Localization of Ctnnb1 1 0.23 0.96 0.17
183 INT325506 Positive_regulation of Localization of Ctnnb1 1 0.05 0.28 0.17
184 INT52943 Positive_regulation of Positive_regulation of Afp 1 0.31 1.11 0.17
185 INT232799 Regulation of Gene_expression of Shh 3 0.27 1.04 0.16
186 INT98772 Localization of Isl1 2 0.65 0 0.16
187 INT201210 Negative_regulation of ISL1 2 0.02 0.4 0.16
188 INT253177 Negative_regulation of Gene_expression of Shh 2 0.55 0.63 0.16
189 INT164161 Regulation of PCSK1 3 0.30 2.09 0.14
190 INT278241 Regulation of IHH 2 0.31 1.16 0.14
191 INT249096 Regulation of FOXF1 1 0.19 0.28 0.14
192 INT135490 Localization of Smad2 1 0.51 0.08 0.14
193 INT245190 Binding of TCF7L2 6 0.48 12.29 0.13
194 INT253190 Localization of Shh 2 0.77 1.06 0.13
195 INT250790 Negative_regulation of Localization of APC 2 0.13 2.3 0.13
196 INT250792 Positive_regulation of Localization of APC 1 0.15 0.48 0.13
197 INT158893 Negative_regulation of Gene_expression of Smad2 1 0.30 0.13 0.13
198 INT215861 Positive_regulation of Negative_regulation of Eif2ak3 1 0.50 1.04 0.13
199 INT130374 Transcription of Ctnnb1 1 0.19 0 0.13
200 INT98774 Regulation of Localization of Isl1 1 0.08 0 0.13
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