GO:0031017

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Name exocrine pancreas development
Categary Process
Go Slim No
Go Link GO:0031017
Unique Molecular Interactions 373
Total Molecular Interactions 532
Total Single Events 5438
Pain Genes Associated 22

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for exocrine pancreas development. They are ordered first by their pain relevance and then by number of times they were reported for exocrine pancreas development. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT142177 Calca Positive_regulation of Gene_expression of Igf1 8 0.78 3.57 5.71
2 INT128296 Negative_regulation of IL1B Positive_regulation of Insr 1 0.10 1.36 4.52
3 INT128295 IL1B Positive_regulation of Insr 1 0.11 1.36 4.5
4 INT128293 Negative_regulation of Aldh1a1 Positive_regulation of Insr 1 0.00 0.99 3.34
5 INT128292 Nts Positive_regulation of Insr 1 0.03 0.99 3.34
6 INT128291 Vom1r68 Positive_regulation of Insr 1 0.00 0.99 3.33
7 INT128294 Aldh1a1 Positive_regulation of Insr 1 0.00 0.99 3.33
8 INT145826 Calca Positive_regulation of Gene_expression of Igf1 3 0.75 3.05 1.66
9 INT89011 Lep Positive_regulation of Insr 1 0.19 2.41 1.57
10 INT290542 Crh Positive_regulation of Insr 1 0.02 0.36 1.36
11 INT131185 PTH Positive_regulation of Gene_expression of IGF1 3 0.44 3.31 1.31
12 INT131184 PTGER2 Positive_regulation of Gene_expression of IGF1 1 0.63 2.47 1.29
13 INT106345 Igf1 Regulation of Localization of Acot1 1 0.06 0 1.02
14 INT12141 Igf1 Negative_regulation of Chat 1 0.32 0.63 1
15 INT140653 IGF1 Negative_regulation of Protein_catabolism of PARP1 1 0.32 0.63 0.98
16 INT140652 IGF1 Positive_regulation of Phosphorylation of MAPK1 1 0.26 0.63 0.98
17 INT114068 Agtr2 Regulation of Gene_expression of Insr 1 0.15 0.95 0.79
18 INT76499 Binding of Insr and Adora2a 1 0.08 0 0.76
19 INT290544 Negative_regulation of Crh Positive_regulation of Insr 1 0.01 0.3 0.72
20 INT28947 GH1 Positive_regulation of Gene_expression of IGF1 4 0.22 3.78 0.69
21 INT34772 GH1 Regulation of IGF1 2 0.32 0.95 0.69
22 INT220148 Binding of IGF1 and IGFBP3 12 0.36 5.56 0.66
23 INT335456 Binding of PDX1 and hb 1 0.02 2.59 0.66
24 INT290549 Gopc Positive_regulation of Positive_regulation of Insr 1 0.01 0.06 0.65
25 INT45369 IGF1 Regulation of GH1 1 0.04 1.12 0.65
26 INT290545 Crh Positive_regulation of Positive_regulation of Insr 1 0.02 0.06 0.64
27 INT290550 Gopc Positive_regulation of Insr 1 0.01 0.06 0.64
28 INT290540 Positive_regulation of Crh Positive_regulation of Insr 1 0.02 0.06 0.64
29 INT46493 Binding of Insr and Oxt 1 0.14 0 0.62
30 INT297340 Apoe Regulation of Binding of Smo 1 0.10 1.1 0.6
31 INT276217 Pdk1 Positive_regulation of Positive_regulation of Insr 1 0.05 0.1 0.6
32 INT89010 Arc Positive_regulation of Insr 1 0.08 0.86 0.59
33 INT89012 DST Positive_regulation of Insr 1 0.01 0.86 0.59
34 INT261828 Igf1 Regulation of Localization of Trpv2 1 0.02 1.04 0.58
35 INT156668 Gh Positive_regulation of Igf1 5 0.22 2.07 0.57
36 INT317639 Igf1 Regulation of Creb1 1 0.23 0.16 0.57
37 INT185809 Binding of PDX1 and SPP1 1 0.02 1.69 0.57
38 INT192291 OR5A1 Positive_regulation of Gene_expression of IGF1 1 0.02 0.93 0.57
39 INT156667 Gh Positive_regulation of Gene_expression of Igf1 6 0.28 0.88 0.56
40 INT150291 Grk1 Positive_regulation of Gene_expression of Igf1 1 0.16 0.98 0.55
41 INT106347 Igf1 Regulation of Chat 1 0.44 0 0.55
42 INT142882 IGF1 Positive_regulation of Gene_expression of TRPV1 1 0.06 0.57 0.52
43 INT114070 Agtr2 Positive_regulation of Gene_expression of Insr 1 0.13 0.34 0.52
44 INT108568 Calca Positive_regulation of Igf1 1 0.51 0.08 0.48
45 INT114065 Akt1 Regulation of Gene_expression of Insr 1 0.13 0.28 0.46
46 INT37599 Ace Regulation of Localization of Insr 1 0.18 0 0.46
47 INT264295 Binding of DMD and IGF1 1 0.07 1.38 0.44
48 INT230437 Binding of PDX1 and HRCT1 1 0.04 2.45 0.43
49 INT221085 GHRH Positive_regulation of Gene_expression of IGF1 2 0.56 1.47 0.41
50 INT303655 Positive_regulation of Binding of IGF1 and SSTR1 1 0.16 2.19 0.41
51 INT285725 Binding of IGF1R and INS 1 0.27 0.07 0.4
52 INT303650 Binding of IGF1 and SSTR1 1 0.12 2.17 0.4
53 INT99304 Igf1 Positive_regulation of Gh1 1 0.44 0.39 0.39
54 INT114067 Ace Regulation of Insr 1 0.09 0.31 0.39
55 INT182492 IL1B Regulation of Gene_expression of IGF1 1 0.01 0.83 0.38
56 INT78444 Binding of GH1 and IGF1 4 0.16 2.82 0.37
57 INT316545 Binding of IGF1 and SST 1 0.06 0.45 0.37
58 INT272951 Binding of TNF and Igf1 1 0.14 1.48 0.36
59 INT272953 Negative_regulation of Binding of TNF and Igf1 1 0.16 1.48 0.36
60 INT336573 Ptpn2 Regulation of INSR 1 0.00 1.36 0.36
61 INT63278 Gpm6a Regulation of Igf1 1 0.01 0 0.36
62 INT230438 Binding of PDX1 and HAUS7 1 0.02 2.29 0.35
63 INT272952 Igf1 Positive_regulation of Localization of TNF 1 0.19 1.53 0.35
64 INT242403 INSR Positive_regulation of Gene_expression of Bdkrb1 1 0.45 0.88 0.35
65 INT322208 HRCT1 Positive_regulation of PDX1 1 0.01 1.31 0.34
66 INT277656 Igf1 Positive_regulation of Igfbp3 1 0.01 0.4 0.34
67 INT72180 Binding of CTRC and Cela1 1 0.00 0.65 0.34
68 INT297342 Binding of Gnb5 and Smo 1 0.02 1.67 0.34
69 INT335455 Negative_regulation of Binding of PDX1 and hb 1 0.02 1.3 0.33
70 INT173947 Il6 Positive_regulation of Gene_expression of IGF1 1 0.05 1.02 0.31
71 INT335446 Binding of PDX1 and COPD 1 0.02 1.99 0.3
72 INT65268 Igf1 Positive_regulation of Col7a1 1 0.48 0 0.3
73 INT309369 Ptf1a Positive_regulation of Pax2 1 0.10 0 0.3
74 INT51275 IGF1 Negative_regulation of INS 2 0.35 0.98 0.29
75 INT323653 Binding of Igf1 and Igfbp1 1 0.20 1.14 0.29
76 INT142885 Positive_regulation of IGF1 Positive_regulation of TRPV1 1 0.04 0.24 0.29
77 INT185806 Binding of PDX1 and MMP7 1 0.02 0.84 0.28
78 INT177476 Gnrhr Positive_regulation of Localization of Igf1 1 0.05 1.01 0.28
79 INT177478 Gnrhr Positive_regulation of Localization of IGF1 1 0.04 1.01 0.28
80 INT173949 Binding of IGF1 and Atp6v1e1 1 0.01 0.89 0.28
81 INT142884 IGF1 Positive_regulation of TRPV1 1 0.04 0.24 0.28
82 INT50303 Igf1 Regulation of Localization of Gnrhr 1 0.05 0.09 0.27
83 INT68872 Ghrh Regulation of IGF1 1 0.09 0.18 0.26
84 INT41406 Binding of Insr and Thtpa 1 0.05 0 0.25
85 INT97188 Gh Positive_regulation of Localization of Igf1 1 0.02 0.54 0.25
86 INT335447 PDX1 Regulation of Gene_expression of COPD 1 0.02 1.03 0.24
87 INT92581 IGF1R Positive_regulation of Gene_expression of PTGER2 1 0.09 0.79 0.24
88 INT215037 Ghrh Regulation of Localization of Igf2 1 0.04 2.12 0.24
89 INT318679 Atf4 Positive_regulation of Gene_expression of Xbp1 1 0.53 0.77 0.23
90 INT7869 Gh Negative_regulation of IGF1 1 0.39 0.47 0.23
91 INT245590 Ghr Positive_regulation of Gene_expression of Igf1 1 0.34 0.61 0.23
92 INT265886 IGF1 Positive_regulation of AKT1 1 0.11 3.06 0.23
93 INT89158 Grpr Positive_regulation of Localization of Insr 1 0.02 0 0.23
94 INT220383 Binding of Igf1 and Cotl1 1 0.03 0.37 0.22
95 INT173946 Igf1 Regulation of Gene_expression of IGF1 1 0.08 0.68 0.21
96 INT173944 IGF1 Regulation of Gene_expression of Igf1 1 0.08 0.68 0.21
97 INT173945 Hrt1 Positive_regulation of Positive_regulation of IGF1 1 0.01 0.32 0.21
98 INT286070 Igf1 Regulation of Regulation of Ins1 1 0.10 1.7 0.2
99 INT106825 Ednra Negative_regulation of Igf1 1 0.07 0.07 0.2
100 INT286071 Igf1 Regulation of Ins1 1 0.10 1.69 0.2
101 INT250537 Ptpn6 Negative_regulation of Igf1 1 0.08 0 0.2
102 INT220146 Binding of IGF1 and IGFBP1 2 0.10 1.57 0.19
103 INT173943 Binding of IGF1 and Il6 1 0.04 0.11 0.19
104 INT334631 Igf1r Positive_regulation of Phosphorylation of Akt1 1 0.19 0.5 0.18
105 INT318677 Xbp1 Positive_regulation of Ddit3 1 0.73 1.72 0.18
106 INT231033 Igf1 Positive_regulation of Sec22b 1 0.06 0 0.17
107 INT175991 Binding of VEGFA and Igf1 1 0.04 0.57 0.17
108 INT220387 Gh1 Regulation of Localization of Igf1 1 0.05 0.3 0.17
109 INT265892 IGF1 Positive_regulation of PIK3CG 1 0.18 1.96 0.16
110 INT59952 Gh Positive_regulation of IGF1 1 0.46 0.84 0.16
111 INT269758 Negative_regulation of IGF1 Negative_regulation of Positive_regulation of IGFBP2 1 0.10 2.15 0.16
112 INT168941 Irs2 Regulation of Gene_expression of Igf1r 1 0.39 0.91 0.16
113 INT73076 IGF1 Positive_regulation of GH1 4 0.45 0.99 0.15
114 INT334634 Binding of Igf1 and Igf1r 1 0.14 0.45 0.15
115 INT185515 Binding of Igf1 and Csf2 1 0.29 0.4 0.15
116 INT92582 IGF1R Positive_regulation of Transcription of PTGER2 1 0.09 0.43 0.15
117 INT50302 Igf1 Regulation of Gh1 1 0.22 0 0.14
118 INT225778 Igf1 Negative_regulation of Positive_regulation of Ppi-rs 1 0.01 0.82 0.14
119 INT220385 Binding of Igf1 and Gnrhr 1 0.05 0.99 0.14
120 INT220386 Binding of Gh1 and Igf1 1 0.07 0.99 0.14
121 INT65272 Igf1 Positive_regulation of Binding of Col7a1 1 0.42 0 0.14
122 INT45371 IGF1 Regulation of Smc1b 1 0.08 0 0.14
123 INT303600 IGF1 Regulation of Gene_expression of GH1 1 0.39 0.83 0.14
124 INT65269 Igf1 Positive_regulation of Gene_expression of Lox 1 0.15 0 0.14
125 INT298715 Igf1 Positive_regulation of Gene_expression of PDGFA 1 0.00 0.22 0.14
126 INT45370 IGF1 Regulation of Gh1 1 0.13 0 0.14
127 INT68753 IGF1 Regulation of Gene_expression of Gh 2 0.02 0.68 0.13
128 INT253009 Igf1 Regulation of PTTG1 1 0.03 0.44 0.13
129 INT215034 Gh Regulation of Igf1 1 0.13 0.27 0.13
130 INT220147 IGFBP3 Positive_regulation of IGF1 1 0.10 0.53 0.13
131 INT65267 Igf1 Regulation of Gene_expression of Plod3 1 0.07 0 0.13
132 INT65271 Igf1 Positive_regulation of Gene_expression of Plod3 1 0.12 0 0.13
133 INT345343 PTCH1 Regulation of Negative_regulation of SMO 1 0.09 2.3 0.13
134 INT228453 Igf1 Positive_regulation of Prkca 2 0.12 1.17 0.12
135 INT228456 Igf1 Positive_regulation of Trpv1 1 0.24 0.97 0.12
136 INT207551 IGF1 Positive_regulation of Gene_expression of GH1 2 0.22 1.18 0.11
137 INT308651 Binding of Igf1 and Ins1 1 0.02 0.22 0.11
138 INT175985 Igf1 Positive_regulation of Gene_expression of Serpina1c 1 0.14 0.55 0.11
139 INT323871 LEP Regulation of Gene_expression of IGF1 1 0.14 1.19 0.11
140 INT50301 Igf1 Positive_regulation of Regulation of Gh1 1 0.24 0 0.11
141 INT222507 Igf1 Positive_regulation of Localization of Edn3 1 0.05 0 0.11
142 INT175987 Igf1 Positive_regulation of Serpina1c 1 0.13 0.54 0.11
143 INT50300 Igf1 Positive_regulation of Gene_expression of Ghrh 1 0.26 0 0.11
144 INT323875 Binding of BMI1 and IGF1 1 0.01 1.2 0.11
145 INT51720 Negative_regulation of Ins1 Negative_regulation of Igf1 1 0.12 0.85 0.11
146 INT173948 Gh Positive_regulation of Gene_expression of IGF1 2 0.36 0.77 0.1
147 INT220149 Binding of IGF1 and IGFALS 2 0.39 0.44 0.1
148 INT267124 IGF1 Negative_regulation of Gene_expression of INS 2 0.14 0.18 0.1
149 INT277657 Igfbp1 Negative_regulation of Negative_regulation of Igf1 1 0.02 0.26 0.1
150 INT161741 Gh1 Positive_regulation of Gene_expression of Igf1 1 0.35 0.55 0.1
151 INT137368 Retn Positive_regulation of Gene_expression of IGF1 1 0.00 0.17 0.1
152 INT25501 Gnrhr Positive_regulation of Igf1 1 0.12 0.09 0.1
153 INT161742 Gnrhr Positive_regulation of Gene_expression of Igf1 1 0.25 0.55 0.1
154 INT190684 Binding of A2M and IGF1 1 0.16 1.54 0.1
155 INT262751 Binding of PTCH1 and SMO 1 0.25 1.29 0.1
156 INT316543 GH1 Regulation of Gene_expression of IGF1 1 0.03 1.32 0.09
157 INT265887 IGF1 Negative_regulation of BCL2 1 0.09 1.02 0.09
158 INT349660 Binding of INSR and PYCARD 1 0.01 0 0.09
159 INT340555 Igf1 Positive_regulation of Mapk1 1 0.24 0.65 0.09
160 INT276141 Binding of Gh and Igf1 2 0.34 0.66 0.08
161 INT325059 Insr Positive_regulation of Ang 1 0.02 1.4 0.08
162 INT115258 Insr Positive_regulation of Phosphorylation of Irs1 1 0.19 0.26 0.08
163 INT49363 Gh Positive_regulation of Igf1 1 0.00 0.49 0.08
164 INT270464 Binding of Shh and Smo 1 0.07 1.3 0.08
165 INT192293 Binding of IGF1 and IL1B 1 0.15 0.08 0.08
166 INT175984 Igf1 Regulation of Localization of Serpina1c 1 0.14 0.54 0.08
167 INT9497 Gh Positive_regulation of Gene_expression of Igf1 1 0.08 0.31 0.08
168 INT325058 Igf1 Positive_regulation of Ang 1 0.04 1.4 0.08
169 INT312219 Binding of IGF1 and IGFBP5 1 0.02 0.13 0.08
170 INT323872 LEP Positive_regulation of Gene_expression of IGF1 1 0.35 0.77 0.07
171 INT265883 IGF1 Positive_regulation of Transcription of FOXO1 1 0.17 1.14 0.07
172 INT70762 IGF1 Regulation of Gh 1 0.00 0.17 0.07
173 INT265882 IGF1 Positive_regulation of Transcription of AKT1 1 0.08 1.13 0.07
174 INT315987 Rhd Positive_regulation of Gene_expression of Igf1 1 0.10 0.47 0.07
175 INT142348 Igf1 Positive_regulation of Akt1 2 0.50 1.16 0.06
176 INT51273 IGF1 Positive_regulation of IGFBP2 1 0.37 0.13 0.06
177 INT142346 Igf1 Positive_regulation of Mapk3 1 0.75 0.33 0.06
178 INT295130 Igf1 Regulation of Grxcr1 1 0.02 0.64 0.06
179 INT343481 Epo Positive_regulation of Igf1 1 0.15 0.31 0.06
180 INT142345 Negative_regulation of Igf1 Positive_regulation of Akt1 1 0.42 0.33 0.06
181 INT295128 Igf1 Regulation of Transcription of Pou1f1 1 0.16 0.64 0.06
182 INT250538 Igf1 Positive_regulation of Gh 1 0.24 0.05 0.06
183 INT78445 Binding of GHRH and IGF1 1 0.20 0.72 0.06
184 INT51276 IGF1 Negative_regulation of GH1 1 0.10 0.13 0.06
185 INT17920 Penk Positive_regulation of Insr 1 0.05 0.14 0.06
186 INT51274 IGF1 Negative_regulation of IGF2 1 0.28 0.13 0.06
187 INT142347 Negative_regulation of Igf1 Positive_regulation of Mapk3 1 0.46 0.33 0.06
188 INT234619 IGF1 Regulation of IGF1R 1 0.11 0.39 0.05
189 INT336338 Glp2r Positive_regulation of Gene_expression of Igf1 1 0.14 0.24 0.05
190 INT218614 INS Positive_regulation of Binding of IGF1 1 0.39 0.79 0.05
191 INT339779 IGF1 Regulation of GHRH 1 0.08 0.38 0.05
192 INT335023 Fgf21 Positive_regulation of Gene_expression of Igf1 1 0.49 0.65 0.05
193 INT234624 Binding of IGF1 and IGF1R 1 0.09 0.39 0.05
194 INT184123 Socs3 Positive_regulation of Protein_catabolism of Insr 1 0.03 0.41 0.05
195 INT287223 Pdx1 Regulation of Transcription of Insig1 1 0.03 0.56 0.05
196 INT112282 Ntf3 Regulation of Igf1 1 0.07 0.14 0.05
197 INT206619 Mtpn Positive_regulation of Igf1 1 0.04 0.17 0.05
198 INT234620 Regulation of Binding of IGF1 and IGF1R 1 0.07 0.39 0.05
199 INT325060 Binding of Insr and Hand1 1 0.00 0.16 0.05
200 INT112281 Cntf Regulation of Igf1 1 0.22 0.14 0.05

Single Events

The table below shows the top 100 pain related interactions that have been reported for exocrine pancreas development. They are ordered first by their pain relevance and then by number of times they were reported in exocrine pancreas development. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT5610 Positive_regulation of Insr 140 0.69 37.26 86.24
2 INT17401 Gene_expression of IGF1 475 0.78 232.18 62.07
3 INT5034 Negative_regulation of Insr 100 0.55 28.08 54.5
4 INT17915 Gene_expression of Insr 141 0.75 47.45 48.59
5 INT14559 Gene_expression of Igf1 254 0.78 112 34.17
6 INT8915 Gene_expression of Igf1 199 0.78 78.58 32.51
7 INT8691 Localization of Insr 85 0.80 9.27 30.32
8 INT5300 Regulation of Insr 54 0.60 11.33 29.26
9 INT9682 Positive_regulation of IGF1 238 0.70 120.03 26.36
10 INT14556 Positive_regulation of Igf1 105 0.69 52.21 24.04
11 INT28951 Negative_regulation of IGF1 133 0.59 75.77 18.9
12 INT171060 Gene_expression of PDX1 72 0.75 72.57 17.97
13 INT28950 Positive_regulation of Gene_expression of IGF1 99 0.69 46.9 16.47
14 INT65263 Positive_regulation of Gene_expression of Igf1 61 0.69 25.69 14.49
15 INT14768 Negative_regulation of Positive_regulation of Insr 16 0.56 5.51 13.59
16 INT17539 Positive_regulation of Igf1 68 0.69 28.47 13.02
17 INT28952 Negative_regulation of Gene_expression of IGF1 75 0.58 41.11 12.32
18 INT110988 Gene_expression of Insr 58 0.42 42.12 12.18
19 INT11729 Regulation of IGF1 71 0.61 44.58 9.71
20 INT149138 Binding of PDX1 27 0.37 32.62 9.33
21 INT34777 Localization of IGF1 82 0.80 42.68 8.62
22 INT3803 Negative_regulation of Igf1 45 0.58 15.95 7.98
23 INT30920 Positive_regulation of Gene_expression of Insr 14 0.66 2.91 7.32
24 INT36405 Positive_regulation of Insr 26 0.66 24.5 7.24
25 INT24622 Positive_regulation of Localization of Insr 15 0.69 0.32 6.85
26 INT142344 Transcription of Igf1 22 0.69 7.55 6.77
27 INT14560 Regulation of Igf1 41 0.59 19.59 6.3
28 INT9494 Positive_regulation of Gene_expression of Igf1 34 0.67 17.77 6.26
29 INT9495 Negative_regulation of Gene_expression of Igf1 31 0.59 11.87 6.1
30 INT9321 Transcription of Igf1 25 0.69 10.2 6.08
31 INT8916 Regulation of Igf1 45 0.60 13.06 5.81
32 INT32611 Phosphorylation of Insr 13 0.80 4.18 5.77
33 INT151032 Localization of Igf1 49 0.76 26.32 5.71
34 INT14769 Positive_regulation of Positive_regulation of Insr 10 0.43 2.66 5.55
35 INT9325 Gene_expression of Igf1r 14 0.77 8.74 5.48
36 INT114058 Negative_regulation of Gene_expression of Insr 13 0.31 9.23 4.97
37 INT10115 Gene_expression of INSR 31 0.75 11.98 4.86
38 INT51392 Negative_regulation of Insr 18 0.27 14.75 4.84
39 INT24620 Negative_regulation of Gene_expression of Insr 14 0.39 6.98 4.61
40 INT14557 Negative_regulation of Igf1 96 0.59 54.83 4.45
41 INT49360 Localization of Igf1 22 0.76 6.96 4.26
42 INT51084 Binding of Insr 13 0.30 4.25 4.23
43 INT83035 Binding of INSR 16 0.47 9.29 4.11
44 INT142174 Regulation of Gene_expression of Igf1 28 0.60 11.86 3.77
45 INT25709 Negative_regulation of Igf2 11 0.56 9.38 3.76
46 INT10116 Localization of INSR 11 0.57 5.43 3.48
47 INT14060 Negative_regulation of Negative_regulation of Insr 6 0.53 3.53 3.44
48 INT133214 Regulation of PDX1 9 0.34 10.26 3.36
49 INT105537 Regulation of Gene_expression of Igf1 15 0.58 6.97 3.23
50 INT124736 Positive_regulation of Gene_expression of Insr 6 0.31 7.55 3.12
51 INT131187 Regulation of Gene_expression of IGF1 18 0.62 11.18 3.05
52 INT14485 Positive_regulation of Cela1 15 0.44 10.55 3.01
53 INT16130 Binding of IGF1 67 0.48 27.43 2.95
54 INT9335 Gene_expression of Igf2 18 0.72 12.76 2.78
55 INT171058 Negative_regulation of PDX1 5 0.32 9.31 2.72
56 INT23527 Negative_regulation of Localization of Insr 10 0.39 2.58 2.5
57 INT139735 Positive_regulation of Transcription of Igf1 4 0.53 1.93 2.49
58 INT66544 Binding of Igf1 23 0.46 8.33 2.44
59 INT9327 Localization of Igf2 8 0.80 5.07 2.36
60 INT15290 Gene_expression of Cela1 17 0.52 7.56 2.22
61 INT57132 Positive_regulation of Igf2 9 0.50 5.15 2.22
62 INT147417 Positive_regulation of Gene_expression of Igf1r 3 0.46 1.69 2.2
63 INT24621 Regulation of Gene_expression of Insr 9 0.42 2.68 2.18
64 INT31006 Regulation of Localization of Insr 7 0.50 0.2 2.05
65 INT156666 Positive_regulation of Localization of Igf1 11 0.62 6.94 1.95
66 INT142341 Positive_regulation of Transcription of Igf1 8 0.49 2.44 1.95
67 INT132971 Negative_regulation of Localization of IGF1 5 0.42 3.98 1.94
68 INT9336 Negative_regulation of Gene_expression of Igf1r 4 0.42 3.53 1.92
69 INT133269 Positive_regulation of PDX1 10 0.54 9.77 1.9
70 INT171059 Localization of PDX1 8 0.56 6.7 1.9
71 INT114059 Localization of Insr 10 0.46 3.49 1.87
72 INT41515 Negative_regulation of CELA1 3 0.51 2.37 1.73
73 INT218303 Protein_catabolism of INSR 3 0.29 0.67 1.73
74 INT232645 Transcription of INSR 2 0.09 1.19 1.71
75 INT66709 Transcription of IGF1 13 0.71 5.65 1.64
76 INT15363 Gene_expression of CELA1 10 0.78 3.22 1.59
77 INT38893 Localization of CELA1 6 0.70 2.36 1.57
78 INT114061 Regulation of Gene_expression of Insr 4 0.27 2.03 1.56
79 INT19342 Regulation of Insr 12 0.24 6.11 1.54
80 INT49361 Regulation of Positive_regulation of Igf1 2 0.45 2.15 1.49
81 INT135959 Negative_regulation of Gene_expression of Igf1 37 0.56 21.16 1.41
82 INT144671 Gene_expression of Xbp1 4 0.75 8.48 1.4
83 INT49128 Gene_expression of IGF1R 35 0.63 23.48 1.39
84 INT90491 Binding of Igf1 25 0.44 9.75 1.36
85 INT183065 Positive_regulation of Gene_expression of PDX1 7 0.54 6.58 1.29
86 INT124738 Negative_regulation of Positive_regulation of Insr 5 0.23 3.73 1.24
87 INT9323 Transcription of Igf1r 2 0.63 1.08 1.23
88 INT10117 Positive_regulation of INSR 10 0.43 4.71 1.22
89 INT175520 Gene_expression of Igf2 43 0.78 48.93 1.21
90 INT9324 Negative_regulation of Gene_expression of Igf2 6 0.50 5.12 1.2
91 INT183068 Gene_expression of SMO 2 0.17 0.27 1.2
92 INT25710 Regulation of Igf2 6 0.62 3.1 1.17
93 INT142616 Negative_regulation of Positive_regulation of Igf1 5 0.43 1.56 1.16
94 INT106339 Positive_regulation of Phosphorylation of Insr 1 0.49 0 1.12
95 INT28949 Negative_regulation of Positive_regulation of IGF1 11 0.42 5.03 1.11
96 INT147416 Positive_regulation of Transcription of Igf1r 1 0.46 0.72 1.1
97 INT147415 Positive_regulation of Igf1r 2 0.43 0.97 1.09
98 INT32354 Negative_regulation of Regulation of Insr 3 0.33 0.13 1.08
99 INT184696 Positive_regulation of Xbp1 12 0.60 13.6 1.06
100 INT72129 Positive_regulation of Positive_regulation of IGF1 11 0.50 4.61 1.05
101 INT169407 Phosphorylation of IGF1 4 0.63 0.83 1.01
102 INT17715 Positive_regulation of CELA1 8 0.61 3.76 1
103 INT171382 Phosphorylation of Insr 6 0.51 3.41 0.94
104 INT118558 Gene_expression of Xbp1 13 0.72 7.98 0.91
105 INT41911 Regulation of Positive_regulation of Insr 2 0.21 0.32 0.88
106 INT171376 Positive_regulation of Phosphorylation of Insr 3 0.31 3.05 0.86
107 INT91908 Regulation of Negative_regulation of Insr 1 0.03 0.81 0.86
108 INT15362 Negative_regulation of Cela1 4 0.21 2.47 0.83
109 INT202241 Positive_regulation of Negative_regulation of IGF1 5 0.48 1.56 0.82
110 INT224958 Negative_regulation of Transcription of Igf1 5 0.56 1.37 0.81
111 INT114714 Binding of IGF1R 8 0.36 5.26 0.78
112 INT270447 Binding of Smo 2 0.07 2.61 0.78
113 INT58245 Regulation of Localization of Igf2 1 0.62 1.27 0.78
114 INT144759 Regulation of Gene_expression of INSR 2 0.44 3.09 0.77
115 INT118567 Regulation of Gene_expression of Xbp1 1 0.23 0.89 0.69
116 INT117392 Binding of Insr 8 0.23 4.88 0.68
117 INT21983 Regulation of Cela1 4 0.18 2.9 0.67
118 INT171366 Positive_regulation of Localization of Insr 3 0.18 0.63 0.66
119 INT35562 Regulation of CELA1 4 0.04 1.67 0.65
120 INT124211 Protein_catabolism of IGF1 2 1.00 1.29 0.63
121 INT18445 Regulation of Transcription of Insr 1 0.12 0.84 0.63
122 INT18446 Transcription of Insr 2 0.18 0.84 0.62
123 INT205957 Negative_regulation of Smo 4 0.08 2.57 0.6
124 INT106343 Positive_regulation of Positive_regulation of Igf1 2 0.69 1.45 0.59
125 INT220365 Negative_regulation of Transcription of Igf1 3 0.45 1.28 0.56
126 INT277644 Negative_regulation of Localization of Igf2 1 0.02 0.69 0.56
127 INT145859 Regulation of Gene_expression of Igf1r 1 0.59 1.58 0.55
128 INT133968 Binding of Pdx1 1 0.32 0.16 0.55
129 INT125578 Positive_regulation of Localization of IGF1 6 0.60 7.59 0.53
130 INT49362 Positive_regulation of Localization of Igf1 4 0.65 2.26 0.53
131 INT308979 Regulation of Localization of Insr 1 0.24 0.44 0.53
132 INT185513 Phosphorylation of Igf1 3 0.67 0.46 0.5
133 INT335452 Regulation of Gene_expression of PDX1 1 0.05 2.56 0.5
134 INT22728 Localization of Cela1 3 0.48 1.69 0.43
135 INT140942 Regulation of Transcription of Igf1 3 0.32 1.37 0.43
136 INT9328 Regulation of Gene_expression of Igf2 1 0.39 0.91 0.42
137 INT15289 Positive_regulation of Gene_expression of Cela1 2 0.46 1.32 0.4
138 INT199340 Localization of Igf2 4 0.75 4.47 0.39
139 INT114062 Negative_regulation of Localization of Insr 1 0.19 0.31 0.39
140 INT157034 Positive_regulation of Xbp1 2 0.45 3.44 0.38
141 INT168940 Phosphorylation of Igf1r 1 0.77 2.18 0.38
142 INT23704 Binding of Cela1 2 0.39 1.03 0.37
143 INT144755 Negative_regulation of INSR 5 0.41 2.09 0.36
144 INT261774 Positive_regulation of Phosphorylation of Igf1 1 0.08 0.09 0.36
145 INT23705 Positive_regulation of Localization of Cela1 2 0.32 1.35 0.35
146 INT57131 Negative_regulation of Positive_regulation of Igf2 1 0.36 0.67 0.35
147 INT200198 Regulation of Localization of Igf1 6 0.58 4.51 0.34
148 INT185840 Positive_regulation of Localization of PDX1 2 0.27 0.78 0.33
149 INT49672 Regulation of Negative_regulation of IGF1 1 0.21 1.07 0.33
150 INT156399 Regulation of Pdx1 1 0.00 0.96 0.33
151 INT105968 Positive_regulation of Binding of Igf1 2 0.20 0.56 0.32
152 INT318668 Negative_regulation of Gene_expression of Xbp1 1 0.56 1.53 0.32
153 INT169405 Negative_regulation of Phosphorylation of IGF1 1 0.07 0.15 0.32
154 INT210766 Gene_expression of Igf1r 6 0.65 2.15 0.31
155 INT83030 Positive_regulation of Binding of INSR 2 0.49 2.35 0.31
156 INT199358 Negative_regulation of Gene_expression of Igf2 3 0.43 4.48 0.3
157 INT356400 Transcription of Smo 1 0.02 0.05 0.3
158 INT202646 Gene_expression of Ptf1a 10 0.48 0.46 0.29
159 INT9329 Transcription of Igf2 2 0.58 1.28 0.29
160 INT277474 Positive_regulation of Gene_expression of SMO 1 0.11 0 0.29
161 INT15361 Positive_regulation of Negative_regulation of Cela1 1 0.03 0.39 0.29
162 INT278530 Regulation of Positive_regulation of Insr 1 0.01 1.96 0.28
163 INT216120 Negative_regulation of SMO 2 0.49 3.05 0.27
164 INT49942 Positive_regulation of Pdx1 5 0.02 1.24 0.26
165 INT332230 Regulation of Pdx1 1 0.01 0.99 0.25
166 INT124735 Positive_regulation of Positive_regulation of Insr 1 0.08 0 0.25
167 INT115253 Negative_regulation of Phosphorylation of Insr 1 0.27 0.56 0.25
168 INT215027 Regulation of Localization of Igf2 1 0.07 1.71 0.24
169 INT202632 Negative_regulation of Ptf1a 2 0.27 0 0.23
170 INT309358 Positive_regulation of Ptf1a 1 0.17 0 0.23
171 INT309357 Negative_regulation of Positive_regulation of Ptf1a 1 0.14 0 0.23
172 INT200200 Positive_regulation of Negative_regulation of Igf1 3 0.47 2.33 0.22
173 INT265899 Regulation of Binding of IGF1 2 0.22 0.94 0.22
174 INT134810 Binding of CELA1 1 0.12 1.02 0.22
175 INT192958 Negative_regulation of IGF1R 8 0.30 6.35 0.21
176 INT250517 Phosphorylation of Igf1r 5 0.79 1.21 0.21
177 INT213792 Positive_regulation of Igf1r 3 0.45 1 0.2
178 INT168938 Negative_regulation of Phosphorylation of Igf1r 1 0.40 1.1 0.19
179 INT173753 Positive_regulation of Negative_regulation of Igf1 1 0.34 0.47 0.19
180 INT172368 Negative_regulation of Binding of IGF1 3 0.42 1.57 0.18
181 INT231055 Regulation of Localization of Igf1 1 0.15 0 0.17
182 INT198357 Negative_regulation of Localization of Igf1 1 0.03 0.51 0.17
183 INT23703 Regulation of Regulation of Cela1 1 0.07 0.68 0.17
184 INT286068 Positive_regulation of Positive_regulation of Igf1 2 0.40 1.03 0.16
185 INT199349 Regulation of Gene_expression of Igf2 4 0.50 4.56 0.15
186 INT318673 Negative_regulation of Xbp1 3 0.41 1.51 0.15
187 INT168939 Negative_regulation of Igf1r 1 0.40 1.01 0.15
188 INT157035 Negative_regulation of Positive_regulation of Xbp1 1 0.15 1.27 0.15
189 INT185511 Regulation of Phosphorylation of Igf1 1 0.37 0 0.14
190 INT184693 Positive_regulation of Gene_expression of Xbp1 3 0.47 4.42 0.13
191 INT175970 Negative_regulation of Phosphorylation of Igf1 2 0.39 2.1 0.13
192 INT9320 Regulation of Transcription of Igf1r 1 0.04 0.36 0.13
193 INT9333 Regulation of Igf1r 1 0.07 0.36 0.13
194 INT21982 Positive_regulation of Regulation of Cela1 1 0.05 0.71 0.13
195 INT285632 Regulation of Binding of Igf1 1 0.37 0.55 0.13
196 INT118235 Positive_regulation of Igf2 9 0.70 10.05 0.12
197 INT92590 Positive_regulation of Gene_expression of IGF1R 3 0.57 2.31 0.12
198 INT76311 Binding of Igf2 2 0.44 1.91 0.12
199 INT212553 Negative_regulation of Transcription of IGF1 1 0.39 0.3 0.12
200 INT92634 Negative_regulation of Binding of Insr 1 0.25 0.08 0.12
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