GO:0031018

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Name endocrine pancreas development
Categary Process
Go Slim No
Go Link GO:0031018
Unique Molecular Interactions 1549
Total Molecular Interactions 2195
Total Single Events 21637
Pain Genes Associated 44

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for endocrine pancreas development. They are ordered first by their pain relevance and then by number of times they were reported for endocrine pancreas development. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT251170 Clu Positive_regulation of Trpv1 1 0.28 2.61 6.49
2 INT79759 Ngf Regulation of Il6 1 0.60 4.62 5.62
3 INT64718 IL1B Positive_regulation of Gene_expression of IL6 15 0.59 9.37 4.48
4 INT57985 Il1b Positive_regulation of Il6 5 0.59 1.66 3.53
5 INT91271 Mtr Regulation of Gene_expression of Il6 1 0.20 0 3.17
6 INT64719 IL1B Positive_regulation of IL6 7 0.41 6.84 3.14
7 INT150888 Il1a Regulation of Il6 1 0.10 3.47 2.93
8 INT86180 SFTPA1 Positive_regulation of Localization of IL6 2 0.06 2.01 2.85
9 INT222522 Il1a Positive_regulation of Gene_expression of Il6 2 0.06 1.79 2.79
10 INT154187 Il6 Positive_regulation of Gene_expression of Cd2 1 0.08 3.07 2.71
11 INT154188 Il6 Positive_regulation of Gene_expression of Atf3 1 0.76 3.07 2.71
12 INT294909 Pax3 Positive_regulation of Gene_expression of Il6 1 0.09 5.43 2.51
13 INT115367 Binding of IL6 and IL6R 12 0.07 8.16 2.36
14 INT124121 IL6 Positive_regulation of CCL2 1 0.26 1.84 2.25
15 INT251164 Binding of Clu and Trpv1 1 0.19 0.44 2.23
16 INT126717 Binding of Il6 and Il6st 3 0.21 3.35 2.22
17 INT124120 IL6 Regulation of CCL2 1 0.15 1.8 2.22
18 INT94492 Il6 Positive_regulation of Gene_expression of Il1b 1 0.27 3.81 2.19
19 INT94504 Il6 Positive_regulation of Gene_expression of Tnf 1 0.30 3.8 2.19
20 INT94494 Il1b Positive_regulation of Gene_expression of Il6 1 0.27 3.81 2.19
21 INT86179 TNF Positive_regulation of Localization of IL6 5 0.35 1.66 2.17
22 INT126400 ITIH4 Positive_regulation of Gene_expression of Il6 1 0.00 2.11 2.08
23 INT70043 IL6 Regulation of IL10 3 0.18 3.59 2.01
24 INT164784 Il6 Positive_regulation of Gene_expression of Cx3cr1 1 0.47 2.37 1.98
25 INT278937 LEP Positive_regulation of Gene_expression of IL6 1 0.32 3.42 1.97
26 INT156509 Il6 Regulation of Positive_regulation of Grin1 1 0.28 1.93 1.93
27 INT102130 Il6 Positive_regulation of Gene_expression of Crp 4 0.05 7.39 1.91
28 INT51051 IL1B Positive_regulation of Localization of IL6 7 0.57 3.79 1.87
29 INT183781 Binding of IL6 and INS 6 0.22 8.97 1.87
30 INT89379 TNF Positive_regulation of Gene_expression of IL6 5 0.50 4.37 1.69
31 INT213071 IL6 Positive_regulation of Gene_expression of CRP 4 0.52 6.58 1.68
32 INT158774 Mapk14 Regulation of Il6 1 0.11 0.08 1.57
33 INT76651 Cpe Positive_regulation of Gene_expression of Il6 1 0.08 0 1.56
34 INT182097 Binding of Il6 and Il1 4 0.07 4.67 1.55
35 INT41100 Mdk Positive_regulation of Localization of INS 1 0.01 0 1.55
36 INT135276 Gt(pU21)50Imeg Negative_regulation of Gene_expression of Il6 1 0.02 0.52 1.52
37 INT76656 POMC Positive_regulation of Gene_expression of Il6 1 0.03 0 1.51
38 INT126718 Binding of Il6 and Il6r 3 0.09 2.33 1.49
39 INT150885 Il6 Regulation of Il10 1 0.22 1.74 1.47
40 INT285569 TNF Negative_regulation of Gene_expression of Il6 1 0.03 2.83 1.46
41 INT155371 VIP Positive_regulation of Localization of IL6 1 0.64 3.37 1.44
42 INT150682 Pomc Regulation of Gene_expression of Eif2ak3 1 0.37 0.17 1.44
43 INT236365 Binding of CD40LG and IL6 3 0.20 4.16 1.42
44 INT172834 Binding of IL6 and T2dm2 1 0.00 6.4 1.4
45 INT223156 Il6 Regulation of A2m 1 0.11 2.79 1.39
46 INT218309 Binding of CRP and IL6 3 0.23 4.78 1.36
47 INT177457 Il1 Positive_regulation of Gene_expression of Il6 3 0.16 4.47 1.35
48 INT160586 IL6 Positive_regulation of Gene_expression of OPRM1 1 0.14 0.54 1.35
49 INT136603 Calca Positive_regulation of Localization of Il6 1 0.67 0.78 1.32
50 INT182096 Positive_regulation of Binding of Il6 and Il1 2 0.09 4.26 1.31
51 INT78066 Tlr4 Positive_regulation of Localization of Il6 5 0.03 0.76 1.25
52 INT121190 KCNMA1 Positive_regulation of Gene_expression of IL6 1 0.03 0.54 1.24
53 INT121189 KCNMA1 Positive_regulation of IL6 1 0.04 0.54 1.23
54 INT70033 IL6 Regulation of PRF1 1 0.03 1.42 1.21
55 INT70047 IL6 Regulation of Negative_regulation of PRF1 1 0.03 1.42 1.21
56 INT70029 IL6 Regulation of Negative_regulation of IL10 1 0.05 1.42 1.21
57 INT131462 NGF Regulation of Localization of INS 1 0.40 0.97 1.2
58 INT98908 Binding of NTRK1 and PKLR 1 0.41 1.95 1.18
59 INT98906 Positive_regulation of Binding of NTRK1 and PKLR 1 0.56 1.95 1.18
60 INT195117 Ptgs2 Positive_regulation of Gene_expression of Il6 1 0.10 3.26 1.16
61 INT185321 Tlr4 Positive_regulation of Gene_expression of Il6 5 0.14 1.97 1.15
62 INT290667 Il6 Positive_regulation of Stat3 3 0.69 2.42 1.15
63 INT94490 Il6 Positive_regulation of Gene_expression of Avp 1 0.33 1.97 1.15
64 INT94508 Il6 Positive_regulation of Gene_expression of AVP 1 0.42 1.96 1.14
65 INT294911 Pax3 Positive_regulation of Il6 1 0.06 1.78 1.14
66 INT94496 Il6 Positive_regulation of Gene_expression of Crh 1 0.29 1.94 1.12
67 INT294710 CRP Positive_regulation of Gene_expression of IL6 1 0.63 1.9 1.12
68 INT83616 Binding of IL6 and IL8 5 0.09 5.8 1.11
69 INT267588 IL10 Negative_regulation of Gene_expression of IL6 1 0.01 2.25 1.11
70 INT223154 Negative_regulation of Mapk14 Negative_regulation of Localization of Il6 1 0.19 1.13 1.11
71 INT223157 Abat Negative_regulation of Localization of Il6 1 0.05 1.13 1.1
72 INT333966 Binding of Il6r and Il6st 1 0.01 1.74 1.1
73 INT94495 Tnf Positive_regulation of Gene_expression of Il6 1 0.30 1.9 1.09
74 INT108547 AKT1 Regulation of MAPKAPK5 1 0.04 1.2 1.08
75 INT57986 Il1b Regulation of Positive_regulation of Il6 2 0.39 0.23 1.05
76 INT120316 Ghrh Regulation of Il6 1 0.11 0.95 1.05
77 INT120310 Ghrh Regulation of Positive_regulation of Il6 1 0.18 0.95 1.05
78 INT61617 PTGER2 Regulation of Gene_expression of IL6 3 0.11 1.13 1.02
79 INT87025 ZAK Positive_regulation of Gene_expression of IL6 2 0.11 1.59 1.02
80 INT218310 IL6 Positive_regulation of Localization of CRP 1 0.29 3.33 1.02
81 INT206074 Binding of IL6 and IL6ST 7 0.32 3.79 1.01
82 INT278946 IL6 Regulation of Gene_expression of IL8 1 0.20 1.9 1
83 INT86181 SFTPA1 Positive_regulation of IL6 1 0.07 0.32 0.99
84 INT244133 DDB1 Positive_regulation of Gene_expression of IL6 1 0.01 1.91 0.99
85 INT40424 CCK Regulation of Localization of INS 1 0.02 0 0.97
86 INT154254 Tnf Positive_regulation of Il6 1 0.36 0.94 0.97
87 INT114320 TNF Positive_regulation of Gene_expression of Il6 1 0.07 1.73 0.97
88 INT75283 SST Negative_regulation of Localization of INS 2 0.47 1.45 0.96
89 INT272984 Il6 Positive_regulation of Gene_expression of Itgam 1 0.24 0.78 0.96
90 INT163390 Il6 Positive_regulation of Gene_expression of Crp 2 0.03 3.42 0.95
91 INT166842 Binding of ANXA1 and Nfkb1 1 0.37 1.64 0.95
92 INT299988 IL6 Positive_regulation of Localization of IL8 1 0.05 0.81 0.94
93 INT182024 TNF Positive_regulation of Gene_expression of Il6 1 0.05 1.58 0.94
94 INT285418 IRF6 Positive_regulation of Localization of IL6 3 0.05 0.66 0.93
95 INT134785 Il2rb Regulation of Gene_expression of IL6 1 0.00 1.16 0.92
96 INT134784 Il2rb Regulation of IL6 1 0.00 1.16 0.92
97 INT78062 Il1a Positive_regulation of Localization of Il6 3 0.24 0.48 0.9
98 INT64717 Pomc Positive_regulation of Il6 1 0.13 0.19 0.9
99 INT91270 Oprd1 Regulation of Gene_expression of Il6 1 0.00 0 0.89
100 INT109103 MMP2 Positive_regulation of INS 1 0.33 1.07 0.89
101 INT159962 Rock2 Regulation of Localization of Il6 1 0.09 2.7 0.88
102 INT91273 Mtr Positive_regulation of Localization of Il6 1 0.17 0 0.88
103 INT91272 Ifng Positive_regulation of Localization of Il6 1 0.29 0 0.88
104 INT231716 Binding of IL6 and DIP 1 0.24 1.55 0.87
105 INT251159 Binding of Clu and Positive_regulation of Trpv1 1 0.16 0 0.87
106 INT76652 Cpe Positive_regulation of Il6 1 0.08 0 0.87
107 INT199499 Il6 Positive_regulation of Transcription of Oprm1 1 0.01 0.8 0.86
108 INT199492 Il6 Positive_regulation of Transcription of Oprm1 1 0.01 0.81 0.86
109 INT199487 Il6 Positive_regulation of Oprm1 1 0.01 0.8 0.86
110 INT199491 Il6 Positive_regulation of Positive_regulation of Il6 1 0.00 0.81 0.86
111 INT199500 Il6 Positive_regulation of Oprm1 1 0.01 0.8 0.85
112 INT342986 PTAFR Positive_regulation of Gene_expression of IL6 1 0.14 0.39 0.84
113 INT54992 Il6 Negative_regulation of Prl 1 0.00 0.86 0.84
114 INT105435 TNF Positive_regulation of IL6 5 0.25 4.45 0.83
115 INT86430 IL6 Positive_regulation of Gene_expression of HP 1 0.15 3.61 0.83
116 INT195217 EGFL7 Negative_regulation of Gene_expression of IL6 1 0.06 1.14 0.83
117 INT342999 IL6 Positive_regulation of Gene_expression of HIST2H2AA3 1 0.00 0.4 0.83
118 INT116106 VEGFA Positive_regulation of AKT1 1 0.12 0.3 0.83
119 INT131463 NTRK1 Regulation of Localization of INS 1 0.41 0.63 0.8
120 INT306271 IL1A Positive_regulation of Gene_expression of IL6 1 0.30 0.85 0.8
121 INT150680 Pomc Negative_regulation of Gene_expression of Eif2ak3 1 0.35 0.07 0.8
122 INT56499 Neurod1 Positive_regulation of Maoa 1 0.47 0 0.8
123 INT135278 Gt(pU21)50Imeg Negative_regulation of Positive_regulation of Il6 1 0.02 0.26 0.8
124 INT160411 Tat Positive_regulation of Il6 1 0.17 0.89 0.8
125 INT181616 INS Positive_regulation of IRS1 1 0.01 1 0.79
126 INT135277 Gt(pU21)50Imeg Negative_regulation of Il6 1 0.02 0.23 0.78
127 INT196577 Negative_regulation of Mapk14 Negative_regulation of Il6 1 0.13 0.45 0.78
128 INT196574 Negative_regulation of Mapk14 Negative_regulation of Gene_expression of Il6 1 0.13 0.45 0.78
129 INT316544 BCL2L11 Regulation of INS 1 0.00 1.36 0.77
130 INT296792 Tlr9 Regulation of Gene_expression of Il6 1 0.06 1.36 0.76
131 INT178579 CNTN2 Positive_regulation of IL6 1 0.07 2.17 0.75
132 INT111194 Binding of NEUROD1 and Pck1 1 0.39 0 0.75
133 INT41165 Gtf3a Regulation of INS 1 0.00 0.15 0.74
134 INT142847 IRF6 Positive_regulation of IL6 5 0.07 1.09 0.73
135 INT248271 IL6 Regulation of Gene_expression of Crp 3 0.27 1.7 0.73
136 INT331599 Tlr9 Positive_regulation of Gene_expression of Il6 1 0.03 1.8 0.73
137 INT124352 Il6 Positive_regulation of Positive_regulation of Gorasp2 1 0.10 1.19 0.73
138 INT41164 Binding of INS and SST 1 0.07 0.14 0.73
139 INT327994 Il6 Positive_regulation of Gene_expression of ROS1 1 0.05 0.55 0.73
140 INT31643 POMC Regulation of INS 1 0.59 0.62 0.73
141 INT172134 Binding of IL6 and IL15 2 0.01 1.18 0.72
142 INT237325 Il6 Positive_regulation of Gene_expression of Ik 2 0.00 2.09 0.72
143 INT209057 Il6 Positive_regulation of Csf2 1 0.03 0.38 0.72
144 INT209039 Il6 Positive_regulation of Il17a 1 0.05 0.38 0.72
145 INT209056 Il6 Positive_regulation of Elf1 1 0.10 0.38 0.72
146 INT209059 Il6 Positive_regulation of Cxcl1 1 0.06 0.38 0.72
147 INT150996 Sfpq Positive_regulation of Gene_expression of Il6 1 0.04 0.7 0.72
148 INT236364 CD40LG Positive_regulation of Gene_expression of IL6 1 0.25 1.37 0.72
149 INT209060 Il6 Positive_regulation of Ccr1 1 0.01 0.38 0.72
150 INT51005 PDYN Positive_regulation of IL6 1 0.08 0.84 0.72
151 INT260551 Igh-Dex Negative_regulation of Il6 1 0.09 0.37 0.72
152 INT159963 Tnf Positive_regulation of Localization of Il6 1 0.12 2.32 0.71
153 INT89936 Tlr4 Positive_regulation of Il6 3 0.49 0.95 0.7
154 INT91700 Il6 Negative_regulation of Oprd1 1 0.23 0 0.7
155 INT251169 Clu Regulation of Ca2 1 0.03 0.66 0.7
156 INT346267 Binding of HGF and IL6 1 0.04 0.96 0.7
157 INT215098 Tlr4 Positive_regulation of Localization of Il6 3 0.18 1.18 0.69
158 INT278968 LEP Regulation of Gene_expression of IL6 1 0.29 1.11 0.69
159 INT150998 Sfpq Negative_regulation of Gene_expression of Il6 1 0.05 0.69 0.69
160 INT81769 Binding of Chrna4 and Neurod1 1 0.35 0.07 0.69
161 INT325270 Il33 Positive_regulation of Gene_expression of Il6 1 0.20 1.59 0.69
162 INT76655 POMC Positive_regulation of Transcription of Il6 1 0.01 0 0.68
163 INT76654 Cpe Positive_regulation of Transcription of Il6 1 0.05 0 0.68
164 INT203758 Binding of IL6 and TNF 3 0.26 2.03 0.67
165 INT251166 Clu Positive_regulation of Trpc3 1 0.09 0.75 0.67
166 INT278953 IL6 Regulation of Gene_expression of PTGER2 1 0.04 1.38 0.67
167 INT102350 P2rx1 Negative_regulation of Localization of Il6 1 0.32 0 0.67
168 INT251171 Clu Positive_regulation of C6 1 0.05 0.75 0.67
169 INT164782 Il6 Regulation of Gene_expression of Cx3cr1 1 0.27 0.79 0.67
170 INT320152 IL6 Positive_regulation of IL1RN 2 0.23 2.59 0.66
171 INT335456 Binding of PDX1 and hb 1 0.02 2.59 0.66
172 INT82384 Penk Positive_regulation of Gene_expression of Il6 1 0.15 0 0.66
173 INT285943 IL17A Positive_regulation of Localization of IL6 3 0.20 2.02 0.65
174 INT121812 IL6 Regulation of OPRM1 1 0.22 0.27 0.65
175 INT209054 Il17a Positive_regulation of Gene_expression of Il6 1 0.10 0.45 0.65
176 INT191494 IL6 Positive_regulation of Binding of CRP 1 0.02 1.65 0.65
177 INT209055 S100a8 Positive_regulation of Gene_expression of Il6 1 0.01 0.45 0.64
178 INT169293 PTPLA Positive_regulation of AKT1 1 0.10 0.15 0.64
179 INT251188 Clu Positive_regulation of TRPV1 1 0.01 0.23 0.64
180 INT64956 IRF6 Positive_regulation of Gene_expression of IL6 4 0.19 1.4 0.63
181 INT183387 Il6 Positive_regulation of Gene_expression of Il10 2 0.19 1.8 0.63
182 INT154263 NEUROD1 Positive_regulation of Gene_expression of GAL 1 0.50 0.06 0.63
183 INT220117 Il6 Positive_regulation of TNF 1 0.01 2.45 0.63
184 INT121188 Negative_regulation of KCNMA1 Positive_regulation of IL6 1 0.04 0.3 0.63
185 INT155458 Tnfrsf1a Regulation of Gene_expression of Il6 1 0.22 1.11 0.63
186 INT71526 Regulation of Il1b Positive_regulation of Il6 1 0.17 0.14 0.62
187 INT264335 Binding of IL-17 and Positive_regulation of Localization of Il6 1 0.13 1.62 0.62
188 INT71527 Negative_regulation of OPRD1 Negative_regulation of Positive_regulation of Il6 1 0.00 0.15 0.62
189 INT278695 MTX1 Negative_regulation of Phosphorylation of AKT1 1 0.04 0.81 0.62
190 INT12610 IAPP Positive_regulation of LGALS1 1 0.07 0.09 0.61
191 INT12611 IAPP Positive_regulation of Localization of LGALS1 1 0.06 0.09 0.61
192 INT114319 TNF Positive_regulation of Gene_expression of Il6r 1 0.05 0.91 0.61
193 INT285939 IL6 Positive_regulation of TEP1 1 0.01 1.76 0.61
194 INT132731 Positive_regulation of Binding of Il1b and Il6 1 0.46 1.2 0.61
195 INT169294 EGF Positive_regulation of Localization of IL6 1 0.18 0.13 0.61
196 INT323773 Binding of Il6 and Lep 1 0.29 3.54 0.6
197 INT242883 INS Negative_regulation of Gene_expression of TLR2 1 0.17 2.35 0.6
198 INT71525 Oprd1 Regulation of Il6 1 0.16 0.19 0.6
199 INT327167 RETNLB Regulation of IL6 1 0.00 2.26 0.6
200 INT91699 Il6 Regulation of Gene_expression of Oprl1 1 0.06 0 0.6

Single Events

The table below shows the top 100 pain related interactions that have been reported for endocrine pancreas development. They are ordered first by their pain relevance and then by number of times they were reported in endocrine pancreas development. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT9238 Gene_expression of IL6 1575 0.78 1135.66 424.22
2 INT9659 Gene_expression of Il6 991 0.78 715.11 265.57
3 INT16868 Gene_expression of Il6 807 0.78 499.48 256.57
4 INT11313 Positive_regulation of Il6 526 0.70 331.27 201.59
5 INT10194 Positive_regulation of IL6 702 0.70 600.62 183.38
6 INT812 Localization of INS 1026 0.81 515.6 145.31
7 INT8243 Positive_regulation of Il6 451 0.70 358.24 119.28
8 INT11051 Positive_regulation of Gene_expression of IL6 415 0.69 319.21 109.3
9 INT3038 Gene_expression of INS 1583 0.78 1174.16 107.01
10 INT12082 Localization of IL6 365 0.81 241.78 105.78
11 INT19511 Localization of Il6 212 0.81 118.17 67.67
12 INT11937 Localization of Il6 228 0.81 139.83 64.39
13 INT9657 Positive_regulation of Gene_expression of Il6 237 0.70 180.45 63.6
14 INT10706 Regulation of Il6 150 0.62 93.23 62.34
15 INT48901 Negative_regulation of IL6 186 0.57 136.33 57.87
16 INT251 Regulation of INS 398 0.62 232.47 55.04
17 INT49993 Positive_regulation of Gene_expression of Il6 149 0.70 88.07 53.78
18 INT9234 Negative_regulation of Gene_expression of IL6 171 0.59 101.61 53.15
19 INT1199 Positive_regulation of INS 579 0.70 399.64 50.43
20 INT9210 Regulation of IL6 166 0.62 125.61 49.95
21 INT1322 Positive_regulation of Localization of INS 293 0.70 120.86 45.98
22 INT50957 Negative_regulation of Il6 134 0.59 79.08 42.67
23 INT11939 Negative_regulation of Il6 138 0.59 87.46 41.24
24 INT3252 Negative_regulation of INS 428 0.59 271.65 39.52
25 INT3253 Negative_regulation of Localization of INS 205 0.59 130.39 36.61
26 INT9239 Regulation of Gene_expression of IL6 106 0.61 75.24 36.53
27 INT2274 Regulation of Localization of INS 101 0.62 41.55 34.79
28 INT9658 Negative_regulation of Gene_expression of Il6 110 0.59 66.29 32.58
29 INT9655 Regulation of Il6 98 0.62 70.92 31.95
30 INT56290 Negative_regulation of Gene_expression of Il6 79 0.59 47.98 31.07
31 INT50230 Positive_regulation of Localization of IL6 105 0.70 69.21 29.52
32 INT86437 Binding of IL6 154 0.48 121.22 29.3
33 INT51474 Binding of Il6 55 0.48 44.99 20.52
34 INT49985 Transcription of Il6 62 0.72 40.13 20.29
35 INT89396 Phosphorylation of AKT1 225 0.82 111.66 19.61
36 INT86187 Positive_regulation of AKT1 199 0.69 122.13 19.44
37 INT51054 Negative_regulation of Localization of IL6 45 0.59 24.48 18.97
38 INT11938 Positive_regulation of Localization of Il6 61 0.70 35.72 18.25
39 INT171060 Gene_expression of PDX1 72 0.75 72.57 17.97
40 INT61626 Transcription of IL6 73 0.72 42.04 17.86
41 INT9656 Regulation of Gene_expression of Il6 57 0.62 33.3 17.71
42 INT50932 Positive_regulation of Positive_regulation of Il6 36 0.69 24.9 16.12
43 INT97245 Gene_expression of AKT1 217 0.77 119.63 15.59
44 INT49532 Regulation of Gene_expression of Il6 43 0.61 25.8 14.99
45 INT49376 Negative_regulation of Localization of Il6 37 0.59 12.66 14.99
46 INT109031 Positive_regulation of Eif2ak3 44 0.69 21.11 14.72
47 INT109034 Gene_expression of Eif2ak3 37 0.77 17.11 14.19
48 INT55256 Negative_regulation of Localization of Il6 38 0.58 16.12 13.67
49 INT14572 Binding of INS 205 0.48 175.43 13.38
50 INT54763 Binding of Il6 82 0.48 63.27 12.89
51 INT8210 Positive_regulation of Gene_expression of INS 188 0.68 146.57 12.83
52 INT55255 Positive_regulation of Localization of Il6 48 0.69 24.88 12.76
53 INT89395 Negative_regulation of AKT1 127 0.58 70.27 12.54
54 INT12084 Regulation of Localization of IL6 36 0.61 20.32 12.34
55 INT13409 Gene_expression of NEUROD1 52 0.75 14.17 12.23
56 INT50933 Transcription of Il6 38 0.72 24.31 11.58
57 INT49396 Negative_regulation of Positive_regulation of Il6 29 0.59 16.39 11.31
58 INT4605 Negative_regulation of Gene_expression of INS 220 0.58 139.66 10.75
59 INT11936 Positive_regulation of Positive_regulation of Il6 34 0.50 26.85 10.59
60 INT58986 Gene_expression of Clu 17 0.77 8.35 9.61
61 INT11047 Positive_regulation of Positive_regulation of IL6 45 0.66 28.7 9.37
62 INT149138 Binding of PDX1 27 0.37 32.62 9.33
63 INT80037 Gene_expression of BAK1 58 0.75 39.49 9.08
64 INT150678 Positive_regulation of Gene_expression of Eif2ak3 17 0.69 6.64 8.99
65 INT6019 Positive_regulation of NEUROD1 37 0.67 17.3 8.89
66 INT2257 Localization of Gip 31 0.74 11.08 7.92
67 INT87139 Negative_regulation of Positive_regulation of Il6 18 0.59 10.65 7.76
68 INT4606 Regulation of Gene_expression of INS 67 0.61 54.69 7.53
69 INT64370 Gene_expression of Neurod1 22 0.75 5.19 7.1
70 INT6097 Negative_regulation of NEUROD1 30 0.57 9.71 6.24
71 INT36757 Gene_expression of Eif2ak3 4 0.74 0.15 6.06
72 INT6098 Binding of NEUROD1 17 0.47 3.4 5.99
73 INT64724 Positive_regulation of Transcription of IL6 26 0.69 13.63 5.96
74 INT4034 Negative_regulation of Gip 16 0.53 6.46 5.65
75 INT51337 Binding of Clu 3 0.12 0.05 5.45
76 INT48840 Gene_expression of Nkx2-2 8 0.23 1.55 5.44
77 INT64716 Regulation of Positive_regulation of Il6 7 0.54 2.83 5.34
78 INT64723 Regulation of Positive_regulation of IL6 13 0.61 12.59 5.19
79 INT49375 Regulation of Localization of Il6 16 0.62 4.54 5.08
80 INT105336 Regulation of AKT1 52 0.56 32.53 4.89
81 INT137336 Phosphorylation of Eif2ak3 14 0.79 4.72 4.78
82 INT52133 Regulation of Localization of Il6 7 0.61 5.35 4.37
83 INT109450 Positive_regulation of Phosphorylation of AKT1 62 0.64 25.18 4.21
84 INT15257 Positive_regulation of Nkx2-2 10 0.21 1.75 4.2
85 INT103345 Positive_regulation of Gene_expression of BAK1 10 0.57 6.4 4.19
86 INT51180 Regulation of Nkx2-2 5 0.26 2.16 4.14
87 INT5602 Positive_regulation of Eif2ak3 9 0.66 0 4.04
88 INT89394 Phosphorylation of INS 37 0.82 35.84 3.9
89 INT8600 Binding of Nkx2-2 6 0.10 0.87 3.82
90 INT85497 Gene_expression of Anxa1 6 0.77 4.7 3.68
91 INT2258 Positive_regulation of Gip 16 0.60 5.51 3.67
92 INT90406 Gene_expression of IL6R 27 0.38 15.74 3.64
93 INT174816 Binding of IL6R 14 0.09 11.26 3.63
94 INT66924 Positive_regulation of Transcription of Il6 18 0.68 11.8 3.53
95 INT20011 Regulation of NEUROD1 10 0.44 3.83 3.53
96 INT64725 Regulation of Transcription of IL6 9 0.45 7.96 3.49
97 INT81403 Positive_regulation of Regulation of Il6 4 0.44 1.81 3.37
98 INT133214 Regulation of PDX1 9 0.34 10.26 3.36
99 INT64715 Phosphorylation of Il6 7 0.81 4.24 3.36
100 INT108203 Negative_regulation of Gene_expression of AKT1 28 0.54 16.38 3.19
101 INT48042 Positive_regulation of Anxa1 5 0.50 3.64 3.19
102 INT126716 Positive_regulation of Il6r 8 0.42 4.31 3.1
103 INT94947 Positive_regulation of Transcription of Il6 9 0.67 6.91 3.04
104 INT89392 Negative_regulation of Positive_regulation of AKT1 23 0.50 15.69 3.02
105 INT134798 Gene_expression of ANXA1 15 0.75 13.94 2.99
106 INT4186 Negative_regulation of Localization of Gip 7 0.53 2.11 2.98
107 INT105783 Protein_catabolism of IL6 7 0.48 4.72 2.95
108 INT38987 Protein_catabolism of INS 21 0.99 11.92 2.91
109 INT2256 Regulation of Gip 14 0.47 4.69 2.91
110 INT32623 Negative_regulation of Regulation of INS 16 0.43 10.96 2.9
111 INT39856 Binding of Neurod1 8 0.47 1.44 2.88
112 INT89401 Negative_regulation of Phosphorylation of AKT1 68 0.58 35.61 2.8
113 INT74293 Positive_regulation of BAK1 13 0.60 14.13 2.73
114 INT35946 Positive_regulation of Clu 12 0.69 4.92 2.73
115 INT171058 Negative_regulation of PDX1 5 0.32 9.31 2.72
116 INT60750 Gene_expression of HNF4A 12 0.65 8.29 2.68
117 INT64714 Positive_regulation of Phosphorylation of Il6 4 0.50 3.22 2.67
118 INT174687 Regulation of Positive_regulation of Il6 10 0.61 9.07 2.61
119 INT203819 Binding of Eif2ak3 9 0.37 5.94 2.57
120 INT15695 Positive_regulation of EIF2AK3 12 0.67 7.01 2.56
121 INT41136 Negative_regulation of Positive_regulation of Gip 4 0.37 1.66 2.45
122 INT10558 Regulation of Regulation of IL6 6 0.45 4.94 2.33
123 INT12618 Positive_regulation of IAPP 54 0.68 32.03 2.29
124 INT333961 Binding of Il6r 1 0.07 3.67 2.29
125 INT3315 Negative_regulation of Positive_regulation of INS 31 0.57 14.73 2.27
126 INT118791 Binding of AKT1 32 0.48 15.51 2.25
127 INT36758 Positive_regulation of Gene_expression of Eif2ak3 1 0.48 0 2.21
128 INT26177 Regulation of Regulation of INS 19 0.44 11.32 2.18
129 INT166838 Positive_regulation of ANXA1 4 0.64 4.88 2.16
130 INT101866 Positive_regulation of Gene_expression of AKT1 49 0.52 17.47 2.14
131 INT58469 Negative_regulation of Positive_regulation of IL6 16 0.42 8.1 2.14
132 INT82048 Positive_regulation of Neurod1 7 0.49 2.39 2.13
133 INT9908 Negative_regulation of IAPP 29 0.57 19.37 2.12
134 INT52197 Negative_regulation of Transcription of Il6 8 0.43 3.8 2.05
135 INT36755 Positive_regulation of Localization of Eif2ak3 1 0.48 0 1.97
136 INT36756 Localization of Eif2ak3 1 0.71 0 1.96
137 INT150675 Regulation of Gene_expression of Eif2ak3 3 0.40 1.11 1.93
138 INT133269 Positive_regulation of PDX1 10 0.54 9.77 1.9
139 INT171059 Localization of PDX1 8 0.56 6.7 1.9
140 INT114317 Gene_expression of Il6r 9 0.54 3.4 1.89
141 INT3866 Positive_regulation of Positive_regulation of INS 30 0.59 21.58 1.86
142 INT64959 Positive_regulation of Negative_regulation of IL6 5 0.42 5.16 1.86
143 INT13999 Positive_regulation of Positive_regulation of NEUROD1 5 0.67 4.07 1.86
144 INT123130 Positive_regulation of Positive_regulation of AKT1 22 0.49 11.77 1.83
145 INT173939 Negative_regulation of IL6R 9 0.11 5.92 1.83
146 INT18845 Regulation of IAPP 11 0.60 9 1.81
147 INT49347 Negative_regulation of Clu 4 0.58 1.63 1.79
148 INT155455 Negative_regulation of Phosphorylation of Il6 1 0.31 2.5 1.76
149 INT36759 Regulation of Gene_expression of Eif2ak3 1 0.59 0 1.74
150 INT160814 Gene_expression of Il6ra 15 0.07 9.61 1.73
151 INT85498 Positive_regulation of Gene_expression of Anxa1 3 0.50 2.12 1.7
152 INT60749 Localization of IAPP 17 0.78 12.57 1.69
153 INT135275 Regulation of Negative_regulation of Il6 4 0.45 0.89 1.67
154 INT109033 Positive_regulation of Positive_regulation of Eif2ak3 2 0.45 2.36 1.59
155 INT65602 Negative_regulation of Neurod1 7 0.42 2.52 1.55
156 INT216932 Positive_regulation of Negative_regulation of Il6 3 0.38 4.88 1.55
157 INT103967 Negative_regulation of Gene_expression of BAK1 8 0.42 7.02 1.54
158 INT85499 Regulation of Anxa1 1 0.27 1.88 1.52
159 INT62800 Regulation of BAK1 7 0.41 10.12 1.47
160 INT112845 Negative_regulation of Binding of Nkx2-2 2 0.12 0.14 1.47
161 INT150677 Negative_regulation of Eif2ak3 9 0.58 6.24 1.46
162 INT98448 Regulation of Binding of Il6 3 0.39 2.6 1.46
163 INT18844 Binding of IAPP 11 0.36 11.01 1.45
164 INT64371 Positive_regulation of Gene_expression of Neurod1 4 0.64 1.56 1.45
165 INT77368 Regulation of Regulation of Il6 3 0.35 1.86 1.45
166 INT98449 Positive_regulation of Binding of Il6 3 0.44 2.96 1.44
167 INT132081 Regulation of Gene_expression of Nkx2-2 2 0.10 0.24 1.43
168 INT87062 Positive_regulation of Binding of IL6 10 0.49 11.8 1.42
169 INT27356 Localization of NEUROD1 8 0.78 3.44 1.39
170 INT215864 Localization of Eif2ak3 5 0.75 3.26 1.36
171 INT18337 Transcription of Eif2ak3 3 0.68 0 1.36
172 INT35944 Regulation of Clu 4 0.20 0.15 1.3
173 INT142017 Positive_regulation of Positive_regulation of BAK1 2 0.52 1.74 1.3
174 INT183065 Positive_regulation of Gene_expression of PDX1 7 0.54 6.58 1.29
175 INT109104 Positive_regulation of Protein_catabolism of INS 4 0.50 4.44 1.24
176 INT18971 Positive_regulation of Gene_expression of NEUROD1 8 0.67 1.91 1.23
177 INT167409 Regulation of Gene_expression of AKT1 8 0.56 4.86 1.23
178 INT172630 Binding of HNF4A 16 0.05 7.78 1.22
179 INT127900 Phosphorylation of EIF2AK3 14 0.80 7.99 1.22
180 INT251180 Phosphorylation of Clu 1 0.29 0.79 1.22
181 INT122988 Gene_expression of CLU 28 0.75 24.07 1.21
182 INT134663 Gene_expression of SOX9 40 0.75 9.07 1.2
183 INT190075 Regulation of Transcription of Il6 2 0.45 2.17 1.18
184 INT135556 Localization of AKT1 38 0.69 12.78 1.17
185 INT3486 Positive_regulation of Regulation of INS 9 0.47 5.65 1.15
186 INT118792 Regulation of Positive_regulation of AKT1 8 0.61 3.73 1.15
187 INT183046 Transcription of INS 25 0.70 11.14 1.13
188 INT176147 Regulation of Phosphorylation of AKT1 14 0.41 6.41 1.13
189 INT97369 Regulation of Gene_expression of NEUROD1 1 0.26 0.25 1.12
190 INT10559 Negative_regulation of Regulation of IL6 4 0.37 1.76 1.1
191 INT114318 Positive_regulation of Gene_expression of Il6r 2 0.28 1.84 1.09
192 INT233561 Gene_expression of Clu 14 0.66 45.63 1.07
193 INT137338 Regulation of Eif2ak3 8 0.45 5.5 1.07
194 INT71233 Negative_regulation of Anxa1 1 0.07 0.15 1.05
195 INT60286 Gene_expression of PKLR 5 0.65 2.14 1.04
196 INT94210 Regulation of Neurod1 2 0.33 0.07 1.04
197 INT172616 Regulation of HNF4A 9 0.06 4.25 1.02
198 INT58470 Negative_regulation of Binding of INS 14 0.43 7.2 1.01
199 INT122151 Localization of Anxa1 1 0.75 0.53 1
200 INT134260 Negative_regulation of Transcription of Il6 2 0.25 1.39 0.99
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