GO:0031091

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Name platelet alpha granule
Categary Component
Go Slim No
Go Link GO:0031091
Unique Molecular Interactions 118
Total Molecular Interactions 175
Total Single Events 1041
Pain Genes Associated 15

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for platelet alpha granule. They are ordered first by their pain relevance and then by number of times they were reported for platelet alpha granule. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT326509 Binding of ACE and VWF 1 0.05 2.07 1.59
2 INT343949 SERPINE2 Positive_regulation of Positive_regulation of Slco1c1 1 0.00 0.59 1.27
3 INT150794 ZNF398 Positive_regulation of Localization of THBS1 1 0.09 1.02 1.07
4 INT343950 SERPINE2 Positive_regulation of Slco1c1 1 0.00 1.63 1.07
5 INT150789 THBS3 Negative_regulation of THBS1 1 0.18 1.01 1.06
6 INT130353 spc Regulation of Fgg 1 0.02 0.2 0.66
7 INT130357 Adcy10 Regulation of Fgg 1 0.03 0.2 0.66
8 INT329589 Serpina5 Positive_regulation of PTX3 1 0.03 1.52 0.66
9 INT96089 Binding of F2 and Pf4 1 0.00 1.31 0.56
10 INT150791 THBS1 Negative_regulation of TIMP2 1 0.17 0.5 0.52
11 INT150796 ZNF398 Positive_regulation of THBS1 1 0.06 0.5 0.52
12 INT150785 THBS1 Negative_regulation of MMP2 1 0.10 0.5 0.52
13 INT63512 Vip Positive_regulation of Localization of SERPINE2 1 0.63 1.84 0.5
14 INT90262 Binding of TAT and Pf4 1 0.03 5.64 0.48
15 INT96095 Binding of Selp and Pf4 1 0.01 1.2 0.45
16 INT96097 Binding of SELP and Pf4 1 0.13 1.2 0.45
17 INT69109 Acot1 Regulation of Gene_expression of Serpine2 1 0.04 0 0.4
18 INT130930 Egr1 Negative_regulation of Positive_regulation of Thbs1 1 0.58 0.64 0.38
19 INT343912 Fgg Positive_regulation of Gene_expression of IL6 1 0.00 0.83 0.35
20 INT354886 Thbs1 Regulation of Positive_regulation of Tgfb1 1 0.17 2.18 0.34
21 INT323352 Binding of F8 and VWF 5 0.08 2.22 0.33
22 INT90263 Binding of PPBP and Pf4 1 0.03 3.71 0.31
23 INT172822 Binding of Fga and T2dm2 1 0.01 2.24 0.31
24 INT203733 Thbs1 Positive_regulation of Negative_regulation of Ppara 1 0.36 1.55 0.26
25 INT252356 Binding of THBS1 and Cd47 1 0.00 0.44 0.24
26 INT252357 Binding of THBS1 and Cd36 2 0.01 2.4 0.21
27 INT63510 SERPINE2 Positive_regulation of Localization of Vip 1 0.15 0.52 0.21
28 INT279964 STAT3 Regulation of Transcription of FGG 1 0.22 1.37 0.2
29 INT337260 ELL Positive_regulation of Gene_expression of THBS1 1 0.11 0.82 0.18
30 INT337263 ELL Regulation of Gene_expression of THBS1 1 0.10 0.82 0.18
31 INT335131 PPARA Negative_regulation of Gene_expression of Fgg 1 0.01 0.59 0.17
32 INT301907 Binding of THBD and VWF 1 0.02 1.71 0.16
33 INT63511 F2 Negative_regulation of SERPINE2 1 0.15 0.97 0.16
34 INT231677 Binding of CD47 and THBS1 1 0.18 0 0.16
35 INT118127 Binding of STXBP3 and Stx4 1 0.01 0.24 0.15
36 INT252352 Binding of THBS1 and Sirpa 1 0.00 0.26 0.15
37 INT281302 Binding of Itgam and Fgg 1 0.00 0.62 0.15
38 INT118126 Binding of STXBP3 and Snap23 1 0.18 0.24 0.15
39 INT92247 Binding of F13a1 and Fgg 1 0.00 0.68 0.14
40 INT323351 Positive_regulation of Binding of F8 and VWF 1 0.03 0.8 0.13
41 INT219788 Binding of Csrp1 and Fgg 1 0.02 0.11 0.1
42 INT294439 KLK4 Negative_regulation of THBS1 1 0.01 0 0.1
43 INT119456 Binding of Itga2b and Fgg 1 0.00 0.14 0.1
44 INT209400 Binding of F13A1 and FGG 1 0.01 1.72 0.09
45 INT54095 ERAP1 Regulation of Protein_catabolism of Fgg 1 0.00 0 0.09
46 INT54096 NRG1 Regulation of Protein_catabolism of Fgg 1 0.01 0 0.09
47 INT348167 Thbs1 Positive_regulation of RAC1 1 0.04 0.71 0.08
48 INT230853 Binding of SELE and VWF 1 0.06 1.3 0.07
49 INT348168 Thbs1 Positive_regulation of PIK3CD 1 0.00 0.65 0.07
50 INT61386 Binding of ITGA2 and Fgg 1 0.00 0.06 0.06
51 INT203732 Thbs1 Regulation of Gene_expression of Ppara 1 0.33 0.94 0.05
52 INT219786 Binding of Col7a1 and Fgg 1 0.00 0.06 0.05
53 INT214847 Binding of VWF and ANGPTL5 1 0.03 1.16 0.05
54 INT232590 Csf2 Positive_regulation of Serpina5 1 0.17 0.65 0.05
55 INT219784 Binding of Serpinc1 and Fgg 1 0.00 0.06 0.05
56 INT341535 F2RL1 Positive_regulation of Gene_expression of THBS1 1 0.28 0.75 0.04
57 INT336631 Binding of Fn1 and Fgg 1 0.00 0.59 0.04
58 INT284096 Binding of MAP4 and VWF 1 0.35 0.82 0.04
59 INT286187 Serpina5 Positive_regulation of Protein_catabolism of Slco1c1 1 0.01 0.41 0.03
60 INT272528 THBS1 Positive_regulation of TGFB2 1 0.09 0.64 0.03
61 INT337270 E2F1 Positive_regulation of Transcription of THBS1 1 0.67 0.19 0
62 INT337268 E2F1 Regulation of Transcription of THBS1 1 0.44 0 0
63 INT151148 Crp Regulation of Gene_expression of Fga 1 0.03 0.07 0
64 INT110123 Positive_regulation of Binding of VWF and Crp 1 0.41 0.19 0
65 INT337274 E2F1 Regulation of THBS1 1 0.44 0 0
66 INT99770 Thbs1 Regulation of PGR 1 0.01 0 0
67 INT337269 Binding of E2F1 and Positive_regulation of Gene_expression of THBS1 1 0.45 0.21 0
68 INT337262 PRB1 Negative_regulation of THBS1 1 0.18 0.61 0
69 INT325902 Binding of F2 and Fgg 1 0.01 0 0
70 INT305316 Binding of Hgf and Serpina5 1 0.21 1 0
71 INT70769 Fga Regulation of F2 1 0.00 0.65 0
72 INT262750 GLYR1 Positive_regulation of THBS1 1 0.01 0.99 0
73 INT99769 Thbs1 Regulation of THBS1 1 0.00 0 0
74 INT277490 Binding of F2 and Thbs1 1 0.09 0 0
75 INT187571 Binding of FANCB and Pf4 1 0.00 0.46 0
76 INT284091 VWF Negative_regulation of PON2 1 0.41 2.32 0
77 INT337264 Binding of E2F1 and THBS1 1 0.47 0.78 0
78 INT268524 MYC Regulation of THBS1 1 0.02 1.85 0
79 INT70770 Fga Regulation of TAPT1 1 0.00 0.65 0
80 INT337273 E2F1 Regulation of Gene_expression of THBS1 1 0.60 0 0
81 INT110124 Binding of VWF and Vwf 1 0.13 0.39 0
82 INT325908 Binding of Wbp5 and Fgg 1 0.00 1.2 0
83 INT65561 Binding of VWF and Atp9b 1 0.22 0.34 0
84 INT305317 Binding of HGF and Serpina5 1 0.04 0.28 0
85 INT110122 Binding of VWF and Crp 1 0.30 0.19 0
86 INT171248 Serpine2 Regulation of Gnrh1 1 0.21 0.07 0
87 INT337266 E2F1 Positive_regulation of Gene_expression of THBS1 1 0.67 0.21 0
88 INT99772 Pgr Regulation of THBS1 1 0.00 0 0
89 INT286188 Twist1 Positive_regulation of Serpina5 1 0.02 0 0
90 INT284094 VWF Negative_regulation of CNDP2 1 0.14 1.16 0
91 INT253020 Pttg1 Negative_regulation of THBS1 1 0.03 0.16 0
92 INT286185 Slco1c1 Positive_regulation of Serpina5 1 0.01 0.23 0
93 INT151144 Il6 Regulation of Gene_expression of Fga 1 0.01 0.07 0
94 INT189548 Binding of SEPT5 and VWF 1 0.01 0.27 0
95 INT277489 Binding of Thbs1 and Gopc 1 0.14 0 0
96 INT171247 Serpine2 Regulation of Gene_expression of Gnrh1 1 0.21 0 0
97 INT337265 Negative_regulation of E2F1 Positive_regulation of THBS1 1 0.42 0 0
98 INT250556 Binding of FGA and HSD11B1 1 0.33 0.57 0
99 INT337272 E2F1 Positive_regulation of THBS1 1 0.49 1.27 0
100 INT337267 THBS1 Positive_regulation of E2F1 1 0.49 0.05 0
101 INT99771 Oxtr Regulation of THBS1 1 0.01 0 0
102 INT325906 Binding of Hps3 and Fgg 1 0.02 0.96 0
103 INT291784 Binding of SERPINE2 and Gnat3 1 0.00 0.3 0
104 INT284090 VWF Negative_regulation of SERPINA1 1 0.04 2.34 0
105 INT110125 Positive_regulation of Binding of VWF and Vwf 1 0.18 0.39 0
106 INT284093 VWF Negative_regulation of APOE 1 0.40 2.32 0
107 INT250552 Binding of FGG and HSD11B1 1 0.25 0.57 0
108 INT268511 MIR19B1 Regulation of THBS1 1 0.20 0.35 0
109 INT130225 Binding of VWF and Serpinc1 1 0.00 0.13 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for platelet alpha granule. They are ordered first by their pain relevance and then by number of times they were reported in platelet alpha granule. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT11069 Positive_regulation of Pf4 35 0.68 27.7 13.96
2 INT14962 Gene_expression of Pf4 27 0.76 22.48 10.88
3 INT60034 Positive_regulation of VWF 40 0.68 30.42 8.15
4 INT117142 Gene_expression of Thbs1 58 0.72 45.02 6.51
5 INT19941 Negative_regulation of Pf4 13 0.42 10.35 5.97
6 INT32458 Gene_expression of VWF 57 0.78 28.97 5.56
7 INT63507 Gene_expression of SERPINE2 8 0.70 8.35 5.56
8 INT22838 Gene_expression of Fgg 26 0.25 19.9 3.88
9 INT55409 Localization of VWF 17 0.80 8.99 3.06
10 INT41358 Localization of Pf4 11 0.79 6.06 2.89
11 INT69099 Gene_expression of Serpine2 22 0.78 7.89 2.87
12 INT32394 Regulation of Pf4 12 0.23 6.07 2.85
13 INT10893 Binding of VWF 27 0.47 25.02 2.82
14 INT94010 Positive_regulation of Localization of VWF 9 0.70 4.23 2.5
15 INT137135 Gene_expression of THBS1 28 0.75 11.55 2.45
16 INT664 Positive_regulation of Fgg 14 0.46 8.75 2.11
17 INT130364 Positive_regulation of Thbs1 7 0.62 7.73 1.97
18 INT60337 Positive_regulation of THBS1 8 0.46 4.69 1.83
19 INT14961 Positive_regulation of Gene_expression of Pf4 4 0.30 3.42 1.7
20 INT17905 Binding of Fgg 9 0.05 4.79 1.68
21 INT154687 Negative_regulation of Fga 1 0.11 1.09 1.58
22 INT58032 Positive_regulation of Localization of Pf4 3 0.67 1.72 1.46
23 INT92245 Negative_regulation of Fgg 13 0.06 9.68 1.35
24 INT288546 Regulation of Positive_regulation of THBS1 1 0.36 2.65 1.27
25 INT150805 Localization of THBS1 4 0.46 2.88 1.23
26 INT163440 Gene_expression of Fgg 1 0.03 2.65 1.19
27 INT63508 Negative_regulation of SERPINE2 6 0.55 3.01 1.11
28 INT203729 Binding of Thbs1 1 0.27 3.83 1.1
29 INT130928 Positive_regulation of Gene_expression of Thbs1 7 0.62 5.62 1.08
30 INT341655 Gene_expression of FGA 1 0.56 4.48 1.07
31 INT17906 Positive_regulation of Binding of Fgg 1 0.03 0.59 1.05
32 INT99767 Regulation of THBS1 18 0.42 11.51 1.03
33 INT305307 Gene_expression of Serpina5 88 0.78 10.09 1
34 INT116459 Negative_regulation of VWF 8 0.58 5.66 0.89
35 INT3086 Binding of Pf4 14 0.47 7.1 0.86
36 INT353154 Localization of FGG 1 0.01 1.34 0.81
37 INT59786 Binding of SERPINE2 4 0.32 2.98 0.79
38 INT130363 Localization of Thbs1 9 0.75 4.99 0.76
39 INT307819 Negative_regulation of Positive_regulation of Pf4 1 0.06 0.44 0.76
40 INT88957 Positive_regulation of Gene_expression of VWF 12 0.42 7.34 0.75
41 INT32314 Positive_regulation of Positive_regulation of Pf4 2 0.49 2.65 0.71
42 INT112649 Negative_regulation of Serpine2 10 0.43 1.41 0.66
43 INT77000 Protein_catabolism of Fgg 5 0.04 3.57 0.64
44 INT63509 Localization of SERPINE2 1 0.75 2.37 0.62
45 INT252993 Negative_regulation of THBS1 8 0.55 6.93 0.59
46 INT69100 Regulation of Gene_expression of Serpine2 1 0.18 0 0.59
47 INT163437 Localization of Fgg 1 0.02 1.38 0.59
48 INT27383 Transcription of Pf4 2 0.66 1.19 0.58
49 INT117145 Negative_regulation of Gene_expression of Thbs1 11 0.43 5.67 0.57
50 INT79839 Positive_regulation of Serpina5 3 0.44 1.2 0.56
51 INT150808 Negative_regulation of Localization of THBS1 1 0.25 0.5 0.53
52 INT27382 Positive_regulation of Transcription of Pf4 1 0.48 0.55 0.51
53 INT220659 Negative_regulation of Negative_regulation of Fgg 1 0.01 2.28 0.49
54 INT112651 Positive_regulation of Gene_expression of Serpine2 3 0.70 3.36 0.47
55 INT268576 Positive_regulation of Gene_expression of THBS1 2 0.64 2.26 0.47
56 INT343948 Positive_regulation of SERPINE2 1 0.07 0.76 0.44
57 INT203728 Regulation of Binding of Thbs1 1 0.33 2.76 0.42
58 INT22837 Regulation of Fgg 2 0.10 1.87 0.41
59 INT203726 Regulation of Thbs1 2 0.33 1.41 0.41
60 INT60035 Regulation of VWF 6 0.42 6.26 0.4
61 INT130927 Negative_regulation of Thbs1 19 0.59 3.72 0.36
62 INT187790 Negative_regulation of Gene_expression of Serpine2 2 0.37 1.23 0.33
63 INT101176 Positive_regulation of Positive_regulation of VWF 3 0.49 1.73 0.31
64 INT81223 Negative_regulation of Binding of VWF 3 0.42 2.09 0.28
65 INT171220 Regulation of Serpine2 3 0.20 0.1 0.28
66 INT94009 Negative_regulation of Localization of VWF 1 0.43 0 0.28
67 INT283300 Transcription of Serpine2 1 0.06 0.67 0.25
68 INT130368 Transcription of Thbs1 2 0.69 1.39 0.23
69 INT130360 Positive_regulation of Transcription of Thbs1 1 0.46 1.41 0.23
70 INT214664 Gene_expression of Serpina5 6 0.26 2.91 0.22
71 INT114709 Gene_expression of Fga 5 0.58 0.92 0.22
72 INT222635 Gene_expression of Thbs1 4 0.39 15.2 0.2
73 INT279977 Transcription of FGG 1 0.47 1.3 0.2
74 INT210033 Negative_regulation of Serpina5 4 0.21 3.99 0.19
75 INT178504 Positive_regulation of Localization of THBS1 2 0.05 1.9 0.19
76 INT34635 Positive_regulation of Regulation of Pf4 1 0.05 0.39 0.18
77 INT341653 Binding of FGA 1 0.31 1.15 0.18
78 INT341661 Protein_catabolism of FGA 1 0.74 1.15 0.18
79 INT151140 Localization of Fga 1 0.11 0.17 0.17
80 INT231474 Binding of THBS1 4 0.34 2.04 0.16
81 INT39120 Regulation of Gene_expression of Pf4 2 0.02 0.21 0.16
82 INT348150 Binding of Thbs1 1 0.24 2.06 0.15
83 INT305312 Regulation of Serpina5 3 0.39 1.85 0.14
84 INT118123 Localization of STXBP3 1 0.48 0.24 0.14
85 INT210032 Binding of Serpina5 4 0.18 1.87 0.12
86 INT147938 Negative_regulation of Binding of Fgg 1 0.03 0.17 0.12
87 INT171236 Localization of Serpine2 2 0.42 0.35 0.11
88 INT197185 Positive_regulation of Gene_expression of Fgg 1 0.05 0.38 0.11
89 INT197186 Positive_regulation of Localization of Fgg 1 0.05 0.38 0.11
90 INT197187 Localization of Fgg 1 0.07 0.38 0.11
91 INT348149 Regulation of Gene_expression of Thbs1 1 0.31 1.94 0.1
92 INT348145 Localization of Thbs1 1 0.41 6.72 0.1
93 INT232589 Positive_regulation of Serpina5 4 0.19 0.8 0.09
94 INT54083 Protein_catabolism of Fgg 1 0.15 0 0.09
95 INT54084 Regulation of Protein_catabolism of Fgg 1 0.07 0 0.09
96 INT157637 Positive_regulation of Fga 2 0.28 0.65 0.08
97 INT50166 Protein_catabolism of Pf4 1 0.01 0.5 0.08
98 INT222588 Negative_regulation of Gene_expression of Thbs1 2 0.30 7.93 0.07
99 INT243336 Negative_regulation of Negative_regulation of SERPINE2 1 0.04 0.21 0.07
100 INT305306 Negative_regulation of Gene_expression of Serpina5 1 0.51 0.79 0.06
101 INT171226 Positive_regulation of Serpine2 2 0.40 0.22 0.05
102 INT222624 Negative_regulation of Thbs1 2 0.30 8.42 0.04
103 INT99763 Regulation of Thbs1 2 0.23 2.08 0.04
104 INT314253 Transcription of VWF 1 0.33 0.07 0.04
105 INT348152 Positive_regulation of Localization of Thbs1 1 0.24 0.85 0.04
106 INT348157 Regulation of Transcription of Thbs1 1 0.14 0.96 0.04
107 INT348147 Transcription of Thbs1 1 0.27 0.96 0.04
108 INT294469 Transcription of THBS1 2 0.66 0.46 0.03
109 INT209407 Positive_regulation of FGG 1 0.24 1.59 0.03
110 INT286180 Protein_catabolism of Serpina5 1 0.29 0.41 0.03
111 INT231690 Negative_regulation of Binding of THBS1 1 0.16 0.37 0.03
112 INT305308 Transcription of Serpina5 1 0.60 0.15 0.03
113 INT209406 Gene_expression of FGG 2 0.45 2.93 0
114 INT219764 Positive_regulation of Negative_regulation of Fgg 2 0.05 0.67 0
115 INT337281 Regulation of Gene_expression of THBS1 1 0.57 0.48 0
116 INT277482 Negative_regulation of Transcription of Thbs1 1 0.43 0 0
117 INT305313 Binding of Serpina5 1 0.37 1.96 0
118 INT305305 Localization of Serpina5 1 0.70 0.31 0
119 INT252974 Positive_regulation of Negative_regulation of THBS1 1 0.03 0.09 0
120 INT279981 Negative_regulation of Gene_expression of FGG 1 0.28 1.17 0
121 INT286179 Regulation of Serpina5 1 0.17 0.13 0
122 INT348156 Positive_regulation of Gene_expression of Thbs1 1 0.24 0.9 0
123 INT305311 Regulation of Gene_expression of Serpina5 1 0.45 0.21 0
124 INT331872 Positive_regulation of Binding of VWF 1 0.12 0 0
125 INT209402 Regulation of Gene_expression of FGG 1 0.16 1.79 0
126 INT325860 Positive_regulation of Protein_catabolism of Fgg 1 0.02 0.67 0
127 INT128758 Regulation of Gene_expression of VWF 1 0.03 0 0
128 INT228789 Positive_regulation of Negative_regulation of Thbs1 1 0.26 0.07 0
129 INT106285 Positive_regulation of Regulation of VWF 1 0.10 0 0
130 INT353111 Positive_regulation of Regulation of Fgg 1 0.01 0.48 0
131 INT348146 Positive_regulation of Thbs1 1 0.25 2.41 0
132 INT286181 Positive_regulation of Binding of Serpina5 1 0.19 0.18 0
133 INT277481 Negative_regulation of Negative_regulation of Thbs1 1 0.59 0 0
134 INT252970 Negative_regulation of Positive_regulation of THBS1 1 0.04 0.2 0
135 INT209408 Regulation of FGG 1 0.09 1.79 0
136 INT348158 Negative_regulation of Positive_regulation of Thbs1 1 0.22 0.65 0
137 INT305309 Negative_regulation of Serpina5 1 0.43 0.4 0
138 INT207312 Phosphorylation of THBS1 1 0.43 0.28 0
139 INT277486 Negative_regulation of Positive_regulation of Thbs1 1 0.43 0 0
140 INT337279 Positive_regulation of Binding of THBS1 1 0.46 0 0
141 INT305310 Positive_regulation of Gene_expression of Serpina5 1 0.60 0.39 0
142 INT171229 Binding of Serpine2 1 0.22 0.06 0
143 INT320827 Negative_regulation of Gene_expression of THBS1 1 0.03 1.52 0
144 INT299913 Binding of Fgg 1 0.27 2.27 0
145 INT239862 Negative_regulation of Positive_regulation of Fgg 1 0.01 0.41 0
146 INT151141 Regulation of Fga 1 0.04 0.08 0
147 INT337283 Positive_regulation of Regulation of THBS1 1 0.46 0 0
148 INT299910 Transcription of Fgg 1 0.34 0.92 0
149 INT171227 Negative_regulation of Regulation of Serpine2 1 0.26 0 0
150 INT305304 Negative_regulation of Negative_regulation of Serpina5 1 0.38 0.23 0
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