GO:0031098

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Name stress-activated protein kinase signaling cascade
Categary Process
Go Slim No
Go Link GO:0031098
Unique Molecular Interactions 56
Total Molecular Interactions 75
Total Single Events 386
Pain Genes Associated 5

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for stress-activated protein kinase signaling cascade. They are ordered first by their pain relevance and then by number of times they were reported for stress-activated protein kinase signaling cascade. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT180442 Acot1 Positive_regulation of Rhoa 1 0.08 1.03 0.38
2 INT140376 TGM1 Positive_regulation of Rhoa 1 0.01 0 0.24
3 INT306178 Rhoa Positive_regulation of Rock2 2 0.40 1.04 0.21
4 INT181765 WISP3 Regulation of Gene_expression of RHOC 1 0.49 1.46 0.21
5 INT180435 Acot1 Positive_regulation of Positive_regulation of Rhoa 1 0.08 0.43 0.19
6 INT180444 Positive_regulation of Acot1 Positive_regulation of Rhoa 1 0.08 0.43 0.19
7 INT180437 Positive_regulation of Acot1 Positive_regulation of Positive_regulation of Rhoa 1 0.08 0.43 0.19
8 INT305335 Olfr927-ps1 Negative_regulation of Akr1b3 1 0.02 1.6 0.17
9 INT180447 Binding of Rhoa and Car2 1 0.17 0.56 0.13
10 INT241454 Rgnef Positive_regulation of Positive_regulation of Rhoa 1 0.04 0.11 0.13
11 INT326387 Binding of PROC and Rhoa 1 0.00 0.59 0.12
12 INT241446 Rgnef Positive_regulation of Rhoa 1 0.04 0.1 0.12
13 INT180445 Edn1 Positive_regulation of Rhoa 1 0.08 0.57 0.11
14 INT180449 Rhoa Regulation of Positive_regulation of Car2 1 0.13 0 0.09
15 INT180443 Rhoa Regulation of Negative_regulation of Mlc1 1 0.04 0 0.09
16 INT326377 Ezr Positive_regulation of Positive_regulation of Rhoa 1 0.05 0.16 0.06
17 INT326378 Binding of Rhoa and Ezr 1 0.04 0.17 0.06
18 INT183863 RHOC Positive_regulation of Gene_expression of MAPK1 1 0.25 0.26 0.05
19 INT326384 Slc9a3r2 Positive_regulation of Positive_regulation of Rhoa 1 0.03 0.16 0.05
20 INT183851 RHOC Positive_regulation of MAPK1 1 0.34 0.26 0.05
21 INT183859 RHOC Positive_regulation of IFI44 1 0.18 0.26 0.05
22 INT183850 RHOC Positive_regulation of Gene_expression of IFI44 1 0.13 0.26 0.05
23 INT180438 Positive_regulation of Rhoa Positive_regulation of Car2 1 0.22 0.48 0.03
24 INT183858 Negative_regulation of RHOC Positive_regulation of MAPK1 1 0.26 0.17 0.03
25 INT181079 Binding of Akt1 and Errfi1 1 0.00 0.8 0.03
26 INT241450 Binding of Rhoa and Dpysl3 1 0.02 0 0.03
27 INT288829 Binding of Rhoa and Rac1 2 0.21 1.88 0
28 INT326383 Binding of Rhoa and Gopc 2 0.04 0.89 0
29 INT254849 Negative_regulation of Rhoa Positive_regulation of Phosphorylation of Smad3 1 0.11 0.45 0
30 INT180446 Rhoa Regulation of Gene_expression of Car2 1 0.21 0.17 0
31 INT334472 Gopc Regulation of Positive_regulation of Rhoa 1 0.02 0.3 0
32 INT254851 C3 Negative_regulation of Rhoa 1 0.06 0 0
33 INT254848 Tgfb1 Negative_regulation of Rhoa 1 0.02 0 0
34 INT342432 Binding of Rhoa and Positive_regulation of Atp9a 1 0.20 0 0
35 INT181078 Binding of Errfi1 and Cdc42ep3 1 0.00 0.73 0
36 INT334469 Gopc Regulation of Localization of Rhoa 1 0.02 0.3 0
37 INT254854 Positive_regulation of C3 Negative_regulation of Rhoa 1 0.05 0 0
38 INT183857 CAV1 Positive_regulation of RHOC 1 0.46 0.21 0
39 INT334473 PGGT1B Regulation of Localization of Rhoa 1 0.04 0.47 0
40 INT183864 Gene_expression of CAV1 Negative_regulation of Positive_regulation of RHOC 1 0.39 0.95 0
41 INT183897 Binding of RHOC and Racgap1 1 0.01 0.2 0
42 INT254865 Rhoa Positive_regulation of Fbrs 1 0.08 0.81 0
43 INT183860 Binding of RHOC and CAV1 1 0.34 0.4 0
44 INT183856 Negative_regulation of RHOC Positive_regulation of Gene_expression of CAV1 1 0.42 0.09 0
45 INT254864 Rhoa Positive_regulation of Egfl7 1 0.02 0.82 0
46 INT334468 Rhoa Regulation of Localization of Rac1 1 0.25 0.18 0
47 INT254853 Rhoa Positive_regulation of Rac1 1 0.10 0.81 0
48 INT180125 Rhoa Positive_regulation of Rock1 1 0.14 0 0
49 INT183866 CAV1 Regulation of RHOC 1 0.25 0.2 0
50 INT183867 Binding of CAV1 and Positive_regulation of Positive_regulation of RHOC 1 0.46 0.1 0
51 INT183852 CAV1 Regulation of Positive_regulation of RHOC 1 0.41 0.63 0
52 INT201741 Binding of Rhoa and Ngfr 1 0.01 1 0
53 INT180439 Rhoa Regulation of Gene_expression of Acot1 1 0.07 0.17 0
54 INT183855 Binding of RHOC and ARHGEF3 1 0.02 1.8 0
55 INT181085 Binding of Cdc42 and Errfi1 1 0.08 0.67 0
56 INT183854 Regulation of CAV1 Positive_regulation of RHOC 1 0.41 0.26 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for stress-activated protein kinase signaling cascade. They are ordered first by their pain relevance and then by number of times they were reported in stress-activated protein kinase signaling cascade. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT146197 Positive_regulation of Rhoa 60 0.68 34.12 12.02
2 INT109861 Gene_expression of Rhoa 11 0.78 5.67 4.02
3 INT146194 Negative_regulation of Rhoa 21 0.42 11.05 3.22
4 INT146191 Gene_expression of Rhoa 32 0.67 17.63 2.92
5 INT140363 Negative_regulation of Rhoa 7 0.58 2.49 2.47
6 INT146196 Localization of Rhoa 6 0.78 4.68 2.3
7 INT131850 Gene_expression of RHOC 17 0.72 29.06 2.28
8 INT146192 Positive_regulation of Positive_regulation of Rhoa 8 0.60 8.15 2.17
9 INT126626 Positive_regulation of Rhoa 14 0.69 4.43 1.87
10 INT146193 Negative_regulation of Positive_regulation of Rhoa 3 0.42 3 1.84
11 INT146190 Negative_regulation of Localization of Rhoa 4 0.42 1.64 1.5
12 INT131848 Positive_regulation of Gene_expression of RHOC 9 0.64 15.43 1.36
13 INT111859 Regulation of Rhoa 3 0.61 0.23 1.22
14 INT135289 Negative_regulation of Akr1b3 4 0.58 5.35 1.15
15 INT140244 Positive_regulation of Akr1b3 3 0.69 2.8 1.12
16 INT180423 Positive_regulation of Gene_expression of Rhoa 7 0.40 6.22 0.98
17 INT146195 Positive_regulation of Localization of Rhoa 4 0.45 2.67 0.84
18 INT231380 Negative_regulation of Phosphorylation of Rhoa 1 0.13 1.28 0.79
19 INT231369 Phosphorylation of Rhoa 1 0.25 1.22 0.73
20 INT316940 Positive_regulation of Phosphorylation of Rhoa 1 0.41 0.41 0.58
21 INT316931 Phosphorylation of Rhoa 1 0.48 0.41 0.57
22 INT140368 Positive_regulation of Positive_regulation of Rhoa 3 0.69 0.2 0.56
23 INT180420 Negative_regulation of Gene_expression of Rhoa 3 0.37 1.65 0.55
24 INT180422 Regulation of Gene_expression of Rhoa 2 0.39 0.6 0.55
25 INT140373 Binding of Rhoa 3 0.48 0.28 0.45
26 INT131851 Positive_regulation of RHOC 3 0.57 9.44 0.41
27 INT131849 Negative_regulation of RHOC 4 0.54 6.46 0.34
28 INT85329 Regulation of Errfi1 1 0.01 0.39 0.28
29 INT140371 Positive_regulation of Negative_regulation of Rhoa 1 0.46 0 0.26
30 INT109859 Localization of Rhoa 3 0.54 1.09 0.24
31 INT289343 Regulation of Gene_expression of Rhoa 1 0.13 0.28 0.23
32 INT140365 Negative_regulation of Protein_catabolism of Rhoa 1 0.43 0 0.23
33 INT140358 Negative_regulation of Positive_regulation of Rhoa 1 0.43 0 0.23
34 INT289342 Negative_regulation of Gene_expression of Rhoa 1 0.20 0.28 0.23
35 INT289353 Positive_regulation of Gene_expression of Rhoa 1 0.23 0.28 0.23
36 INT180415 Regulation of Rhoa 7 0.53 3.92 0.22
37 INT140359 Positive_regulation of Protein_catabolism of Rhoa 1 0.69 0 0.22
38 INT140369 Protein_catabolism of Rhoa 1 0.99 0 0.22
39 INT180418 Binding of Rhoa 16 0.32 7.05 0.2
40 INT140361 Regulation of Positive_regulation of Rhoa 1 0.45 0 0.17
41 INT123396 Gene_expression of Akr1b3 1 0.50 1.2 0.17
42 INT123395 Positive_regulation of Gene_expression of Akr1b3 1 0.37 1.2 0.17
43 INT131847 Negative_regulation of Gene_expression of RHOC 2 0.39 1.38 0.12
44 INT131852 Positive_regulation of Negative_regulation of RHOC 1 0.46 1.12 0.12
45 INT172526 Regulation of RHOC 2 0.51 4.7 0.1
46 INT282407 Transcription of Rhoa 1 0.15 0.52 0.1
47 INT109862 Negative_regulation of Localization of Rhoa 1 0.33 0.37 0.08
48 INT148812 Localization of RHOC 2 0.62 1.75 0.05
49 INT126629 Negative_regulation of Transcription of Rhoa 1 0.33 0 0.05
50 INT180419 Regulation of Positive_regulation of Rhoa 2 0.39 0.9 0.04
51 INT126630 Transcription of Rhoa 1 0.54 0 0.04
52 INT305321 Regulation of Negative_regulation of Akr1b3 1 0.14 1.18 0
53 INT305319 Regulation of Akr1b3 1 0.14 1.17 0
54 INT183874 Negative_regulation of Positive_regulation of RHOC 1 0.35 0.18 0
55 INT183884 Positive_regulation of Binding of RHOC 1 0.41 0.27 0
56 INT183891 Regulation of Positive_regulation of RHOC 1 0.22 0.37 0
57 INT212954 Positive_regulation of Negative_regulation of Rhoa 1 0.19 1.18 0
58 INT191647 Regulation of Regulation of Rhoa 1 0.13 0.32 0
59 INT183887 Binding of RHOC 1 0.40 3.01 0
60 INT183875 Positive_regulation of Positive_regulation of RHOC 1 0.38 0.73 0
61 INT334441 Regulation of Localization of Rhoa 1 0.33 0.88 0
62 INT183872 Regulation of Gene_expression of RHOC 1 0.32 0.34 0
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