GO:0031145

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Name anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process
Categary Process
Go Slim No
Go Link GO:0031145
Unique Molecular Interactions 99
Total Molecular Interactions 143
Total Single Events 915
Pain Genes Associated 24

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process. They are ordered first by their pain relevance and then by number of times they were reported for anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT113844 CDKN1A Negative_regulation of CDK2 4 0.49 1.18 1.27
2 INT225158 Binding of CDK2 and CDKN1A 7 0.30 3.26 1.02
3 INT79602 Binding of PSMA5 and Oprd1 2 0.19 1.05 1.01
4 INT144286 ACP1 Negative_regulation of Phosphorylation of PSMC6 1 0.45 0.39 0.78
5 INT72229 Binding of NFKBIL1 and BTRC 1 0.00 0 0.73
6 INT164265 TGM7 Negative_regulation of CDK2 1 0.26 1.08 0.53
7 INT164264 TGM7 Negative_regulation of CCNB1 1 0.07 1.08 0.53
8 INT72230 Binding of BTRC and EMID1 1 0.00 0 0.49
9 INT72227 Binding of BTRC and AP1M2 1 0.00 0 0.49
10 INT177794 BUB1B Positive_regulation of Gene_expression of ASNS 1 0.11 0.77 0.46
11 INT177781 BUB1B Positive_regulation of ATF4 1 0.07 0.76 0.46
12 INT177780 BUB1B Positive_regulation of ASNS 1 0.05 0.76 0.46
13 INT177787 BUB1B Positive_regulation of MTHFD2 1 0.15 0.76 0.46
14 INT13879 Binding of PSMB9 and KCNAB2 1 0.03 0.19 0.41
15 INT303995 Lep Positive_regulation of PSME1 1 0.09 0.32 0.29
16 INT225160 Negative_regulation of Binding of CDK2 and CDKN1A 1 0.35 0 0.25
17 INT35178 Binding of STT3A and PSME3 1 0.01 0.38 0.25
18 INT72231 Negative_regulation of Binding of NFKBIL1 and BTRC 1 0.00 0 0.24
19 INT180503 Binding of SARS and PSMD6 1 0.22 2.44 0.16
20 INT88410 BMP7 Negative_regulation of CDK2 1 0.35 0 0.14
21 INT252902 PTTG1 Regulation of MMP2 1 0.01 1.5 0.14
22 INT253009 Igf1 Regulation of PTTG1 1 0.03 0.44 0.13
23 INT253015 Egf Regulation of PTTG1 1 0.02 0.44 0.13
24 INT252901 PTTG1 Regulation of Gene_expression of TSC1 1 0.00 1.61 0.13
25 INT57014 PSMB1 Regulation of SCN5A 1 0.02 0 0.1
26 INT306274 Binding of CCNB1 and CDK1 1 0.19 0.13 0.09
27 INT298351 PSMD1 Regulation of Gene_expression of HLA-DRA 1 0.01 0.42 0.08
28 INT298356 PSMD1 Regulation of Gene_expression of Cd14 1 0.04 0.42 0.08
29 INT320267 CCNA2 Positive_regulation of CDK1 1 0.12 1.08 0.08
30 INT166784 Binding of PSMD1 and Nkx6-2 1 0.21 0.5 0.08
31 INT88411 Positive_regulation of PDGFA Positive_regulation of CDK2 1 0.11 0 0.07
32 INT258021 Positive_regulation of Binding of CDK2 and CDKN1A 1 0.11 0.84 0.07
33 INT88408 PDGFA Positive_regulation of CDK2 1 0.11 0 0.07
34 INT253023 Binding of PTTG1 and Myc 1 0.16 0.22 0.04
35 INT231605 Binding of PSMD1 and SGCG 1 0.02 0.34 0.04
36 INT252897 Binding of PTTG1IP and PTTG1 1 0.04 0.15 0.04
37 INT252892 PTTG1IP Regulation of PTTG1 1 0.05 0.49 0.04
38 INT261728 PSMB6 Negative_regulation of Transcription of F2R 1 0.01 0.17 0.03
39 INT261731 PSMB6 Regulation of COL5A2 1 0.00 0.21 0.03
40 INT253010 Binding of PTTG1 and Fgf2 1 0.07 0.51 0.03
41 INT287479 PSMB10 Positive_regulation of TBK1 1 0.00 0.59 0.03
42 INT94159 Positive_regulation of CDK1 Negative_regulation of RB1 1 0.45 0.93 0.03
43 INT94158 CDK1 Negative_regulation of RB1 1 0.41 0.92 0.03
44 INT289608 Binding of CDK2 and CCNE2 5 0.06 4.89 0
45 INT219412 CDK2 Regulation of PCNA 1 0.20 0.11 0
46 INT318081 Binding of RPL5 and UBC 1 0.02 0.52 0
47 INT182397 NFYA Regulation of CCNB1 1 0.00 0.09 0
48 INT209454 Binding of PSMD1 and PSMD2 1 0.15 0 0
49 INT165318 Binding of PSMD1 and CHPT1 1 0.23 0.57 0
50 INT252910 PTTG1 Negative_regulation of Transcription of SLC5A5 1 0.02 0.36 0
51 INT268321 Cdc20 Positive_regulation of Mcm5 1 0.09 0.25 0
52 INT253011 Negative_regulation of Binding of PTTG1 and Zic2 1 0.01 0.41 0
53 INT325156 CDKN1B Negative_regulation of CDK2 1 0.49 0.11 0
54 INT182402 E2F2 Regulation of CCNB1 1 0.00 0.09 0
55 INT276607 Binding of DBT and PSMD1 1 0.00 0.08 0
56 INT253021 PTTG1 Regulation of Gene_expression of Fgf2 1 0.04 0.35 0
57 INT252906 Binding of SLC5A5 and PTTG1 1 0.01 0.69 0
58 INT253007 Igf1 Regulation of Gene_expression of PTTG1 1 0.03 0.46 0
59 INT209452 Binding of PSMD2 and PSMD3 1 0.07 0.2 0
60 INT318103 Binding of UBC and Hprt 1 0.10 0.52 0
61 INT182399 E2F2 Regulation of CDK1 1 0.00 0.09 0
62 INT253018 Binding of PTTG1 and Zic2 1 0.01 0.76 0
63 INT219425 CCNA2 Regulation of SKP2 1 0.11 0.11 0
64 INT219411 CCNF Regulation of SKP2 1 0.22 0.11 0
65 INT182406 NFYA Regulation of CDK1 1 0.00 0.09 0
66 INT219426 CDK2 Regulation of HNF4A 1 0.01 0.11 0
67 INT268320 Cdc20 Positive_regulation of Orc2 1 0.08 0.25 0
68 INT299698 Binding of CFB and PSMC2 1 0.00 0.14 0
69 INT276379 Binding of SKP2 and Cdkn1b 1 0.02 0.57 0
70 INT253008 PTTG1 Regulation of Gene_expression of Id3 1 0.03 0.2 0
71 INT252900 PTTG1 Regulation of Gene_expression of TAF9 1 0.20 0.84 0
72 INT268319 Cdk1 Positive_regulation of Cdc20 1 0.32 0.25 0
73 INT314688 Binding of CCNE1 and CDK2 1 0.04 1.41 0
74 INT209453 Binding of PSMD1 and PSMD3 1 0.08 0.2 0
75 INT253016 Binding of PTTG1 and Id3 1 0.04 0.07 0
76 INT219413 CDK2 Regulation of SKP2 1 0.23 0.11 0
77 INT252896 INS Regulation of Gene_expression of PTTG1 1 0.00 0.47 0
78 INT268324 Cdc20 Positive_regulation of Mcm7 1 0.09 0.25 0
79 INT252907 Binding of PTTG1 and PTTG2 1 0.07 0.08 0
80 INT175194 Binding of UBC and NUP62 1 0.01 0.05 0
81 INT252893 PTTG1 Positive_regulation of Gene_expression of TAF9 1 0.21 0.9 0
82 INT276302 Binding of SKP2 and CIB1 1 0.03 0.57 0
83 INT322544 Binding of CDK2 and Ccne1 1 0.16 0 0
84 INT322503 Negative_regulation of Binding of CDK2 and CCNE2 1 0.01 0.25 0
85 INT268323 Cdc20 Positive_regulation of Mcm3 1 0.08 0.25 0
86 INT276608 Binding of UBE2S and IL33 1 0.00 0.32 0
87 INT299708 Binding of C3 and PSMC2 1 0.00 0.14 0
88 INT252899 PTTG1 Regulation of Gene_expression of SLC5A5 1 0.01 0.43 0
89 INT219419 CDK2 Regulation of E2F2 1 0.23 0.11 0
90 INT253022 PTTG1 Negative_regulation of Negative_regulation of Trp53 1 0.03 1.34 0
91 INT252909 FZR1 Positive_regulation of APC 1 0.06 0.08 0
92 INT252895 PTTG1 Regulation of Gene_expression of VEGFA 1 0.03 0.15 0
93 INT219415 CCNE2 Regulation of SKP2 1 0.11 0.11 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process. They are ordered first by their pain relevance and then by number of times they were reported in anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT69592 Positive_regulation of PSMD1 27 0.70 17.83 18.98
2 INT151747 Positive_regulation of PSMD2 26 0.68 17.48 17.89
3 INT141151 Regulation of PSMD1 16 0.40 8.19 5.86
4 INT151748 Positive_regulation of Positive_regulation of PSMD2 4 0.49 4.45 5.35
5 INT17110 Gene_expression of PSMD1 60 0.65 19.57 4.69
6 INT69591 Positive_regulation of Positive_regulation of PSMD1 2 0.50 3.06 3.99
7 INT88414 Negative_regulation of CDK2 30 0.57 18.4 3.96
8 INT69593 Negative_regulation of PSMD1 11 0.57 4.06 3.33
9 INT51993 Gene_expression of PSMA5 5 0.75 2.59 2.92
10 INT140547 Negative_regulation of PSMB10 3 0.02 2.33 2.92
11 INT54749 Binding of BTRC 7 0.09 0.88 2.9
12 INT24443 Gene_expression of PSMD2 20 0.54 7.29 2.77
13 INT60440 Localization of PSMD1 10 0.74 3.94 2.57
14 INT106616 Gene_expression of PSMB9 35 0.72 28.4 2.29
15 INT69027 Binding of PSMA5 4 0.47 1.08 1.93
16 INT239093 Gene_expression of PTTG1 84 0.65 83.94 1.87
17 INT148721 Binding of PSMD1 13 0.31 4.78 1.76
18 INT88412 Positive_regulation of CDK2 17 0.57 8.49 1.66
19 INT159185 Positive_regulation of Gene_expression of PSMD2 3 0.40 1.4 1.63
20 INT164152 Negative_regulation of PSMD2 9 0.37 3.41 1.56
21 INT54750 Gene_expression of BTRC 4 0.14 0.99 1.55
22 INT69513 Regulation of PSMA5 2 0.60 1.04 1.43
23 INT108587 Negative_regulation of PSMA5 1 0.57 1.73 1.42
24 INT6018 Positive_regulation of PSMB9 7 0.60 4.36 1.33
25 INT79660 Phosphorylation of PSMC6 3 0.80 0.45 1.28
26 INT67638 Positive_regulation of PSMA5 1 0.21 1.15 1.05
27 INT106735 Phosphorylation of CDK2 11 0.79 4.03 1.02
28 INT13882 Binding of PSMB9 3 0.15 2.84 1
29 INT78322 Positive_regulation of PSME1 2 0.44 1.8 0.95
30 INT144289 Negative_regulation of Positive_regulation of PSMC6 1 0.41 0.56 0.92
31 INT144287 Positive_regulation of PSMC6 1 0.49 0.56 0.92
32 INT113841 Gene_expression of CCNB1 11 0.75 3.46 0.86
33 INT78323 Negative_regulation of PSME1 1 0.37 0.5 0.78
34 INT108590 Negative_regulation of Negative_regulation of PSMA5 1 0.57 0.92 0.75
35 INT252975 Positive_regulation of Gene_expression of PTTG1 36 0.28 31.96 0.74
36 INT258791 Positive_regulation of CDK1 14 0.45 5.73 0.74
37 INT62273 Gene_expression of CDK1 19 0.75 8.43 0.68
38 INT105330 Gene_expression of CDK2 31 0.63 13.7 0.67
39 INT108586 Positive_regulation of Negative_regulation of PSMA5 1 0.49 0.82 0.67
40 INT122497 Gene_expression of UBE2S 2 0.58 0.8 0.64
41 INT106608 Regulation of Gene_expression of SKP2 1 0.50 0.26 0.63
42 INT106603 Gene_expression of SKP2 5 0.63 6.99 0.62
43 INT113846 Negative_regulation of Positive_regulation of CDK2 1 0.48 0.39 0.6
44 INT17109 Regulation of Gene_expression of PSMD1 3 0.44 0.86 0.58
45 INT16681 Positive_regulation of PSMC2 1 0.07 0 0.54
46 INT163285 Negative_regulation of Phosphorylation of CDK2 2 0.32 0.52 0.48
47 INT62272 Negative_regulation of CDK1 9 0.57 6.46 0.46
48 INT177869 Gene_expression of BUB1B 2 0.65 2.11 0.45
49 INT177866 Negative_regulation of BUB1B 1 0.32 1.23 0.45
50 INT306885 Positive_regulation of SKP2 1 0.21 0.6 0.45
51 INT177845 Negative_regulation of Gene_expression of BUB1B 1 0.23 0.75 0.45
52 INT350879 Negative_regulation of Localization of PSMD1 1 0.05 0.43 0.43
53 INT202762 Gene_expression of PSMD3 8 0.47 1.44 0.42
54 INT280564 Negative_regulation of Gene_expression of PSMB9 5 0.54 5.99 0.41
55 INT78324 Regulation of PSME1 1 0.61 0.49 0.41
56 INT203568 Regulation of SKP2 3 0.26 1.61 0.38
57 INT280560 Positive_regulation of Gene_expression of PSMB9 7 0.64 6.44 0.36
58 INT252989 Localization of PTTG1 1 0.32 1.49 0.36
59 INT335718 Regulation of Gene_expression of PSMD2 1 0.09 0.07 0.35
60 INT11689 Binding of PSMD2 16 0.36 2.77 0.34
61 INT57019 Gene_expression of PSMB1 1 0.38 0 0.34
62 INT11688 Binding of PSMD3 5 0.36 1.17 0.28
63 INT189953 Regulation of PTTG1 2 0.18 6.45 0.25
64 INT72235 Negative_regulation of BTRC 3 0.02 0 0.24
65 INT131823 Negative_regulation of PSMB6 2 0.01 0.09 0.24
66 INT106733 Regulation of CDK2 6 0.44 4.76 0.23
67 INT322282 Localization of PSMD2 2 0.20 1.42 0.22
68 INT209076 Negative_regulation of PSME3 2 0.34 0.86 0.21
69 INT94166 Phosphorylation of CDK1 10 0.79 4.75 0.2
70 INT165973 Phosphorylation of PSMA5 1 0.79 0.07 0.2
71 INT165972 Positive_regulation of Phosphorylation of PSMA5 1 0.49 0.07 0.2
72 INT280553 Regulation of PSMB9 2 0.57 1.46 0.19
73 INT209077 Positive_regulation of Negative_regulation of PSME3 1 0.37 0.13 0.19
74 INT252977 Positive_regulation of PTTG1 1 0.28 8.39 0.18
75 INT163284 Negative_regulation of Gene_expression of CDK2 5 0.32 1.6 0.16
76 INT57020 Transcription of PSMB1 1 0.26 0 0.16
77 INT173184 Regulation of CDK1 4 0.30 2.97 0.15
78 INT90493 Negative_regulation of PSMB9 3 0.54 0.88 0.15
79 INT62271 Negative_regulation of Gene_expression of CDK1 2 0.42 1.32 0.14
80 INT233867 Negative_regulation of SKP2 3 0.24 2.25 0.13
81 INT201462 Binding of CDK2 12 0.39 5.2 0.12
82 INT15564 Regulation of PSMD2 1 0.00 0 0.12
83 INT165320 Protein_catabolism of PSMD1 1 0.61 1.37 0.11
84 INT165319 Regulation of Protein_catabolism of PSMD1 1 0.31 1.37 0.11
85 INT167436 Localization of CDK1 2 0.14 0.41 0.1
86 INT334958 Positive_regulation of Localization of PSMD1 1 0.10 0.87 0.1
87 INT201460 Positive_regulation of Gene_expression of CDK2 5 0.52 2.8 0.09
88 INT169428 Regulation of Gene_expression of CDK2 4 0.46 1.03 0.09
89 INT186055 Binding of CDK1 3 0.35 1.43 0.09
90 INT106732 Regulation of Phosphorylation of CDK2 2 0.44 0.8 0.09
91 INT239095 Negative_regulation of PTTG1 2 0.32 8.24 0.09
92 INT302272 Localization of CDK2 2 0.30 1.09 0.09
93 INT306284 Binding of CCNB1 1 0.28 0.13 0.09
94 INT280554 Negative_regulation of Positive_regulation of PSMB9 1 0.40 0.9 0.09
95 INT233872 Negative_regulation of Negative_regulation of SKP2 2 0.24 0.94 0.08
96 INT189116 Gene_expression of PSMB10 1 0.18 0.3 0.08
97 INT285256 Positive_regulation of Negative_regulation of PSMD2 1 0.04 0 0.08
98 INT337665 Positive_regulation of PSME3 1 0.45 2.51 0.07
99 INT113842 Negative_regulation of CCNB1 1 0.40 0.53 0.06
100 INT166204 Gene_expression of PSME1 3 0.32 1.94 0.05
101 INT202765 Positive_regulation of PSMD3 1 0.12 0.51 0.05
102 INT263801 Localization of PSME1 2 0.07 1.72 0.04
103 INT318095 Gene_expression of UBC 1 0.16 1.24 0.04
104 INT337650 Positive_regulation of Positive_regulation of PSME3 1 0.32 1.33 0.04
105 INT252992 Regulation of Gene_expression of PTTG1 1 0.18 5.07 0.04
106 INT252980 Binding of PTTG1 1 0.19 0.59 0.04
107 INT337661 Positive_regulation of Positive_regulation of PSME1 1 0.05 1.31 0.04
108 INT337662 Localization of PSME3 1 0.52 1.26 0.04
109 INT94160 Positive_regulation of Phosphorylation of CDK1 2 0.49 0.93 0.03
110 INT186663 Protein_catabolism of PSMB9 2 0.60 0.39 0.03
111 INT201468 Negative_regulation of Binding of CDK2 2 0.17 1.1 0.03
112 INT94161 Negative_regulation of Phosphorylation of CDK1 1 0.41 0.93 0.03
113 INT214219 Regulation of PSMD6 1 0.01 0.05 0.03
114 INT252966 Negative_regulation of Gene_expression of PTTG1 1 0.23 2.7 0.03
115 INT329787 Regulation of CCNB1 1 0.08 1.21 0.03
116 INT252979 Positive_regulation of Localization of PTTG1 1 0.20 0.18 0.03
117 INT214220 Gene_expression of PSMD6 3 0.65 0.83 0
118 INT169427 Transcription of CDK2 2 0.09 0.42 0
119 INT227884 Positive_regulation of Gene_expression of PSMD1 2 0.06 0.4 0
120 INT189952 Transcription of PTTG1 2 0.21 1.6 0
121 INT87528 Negative_regulation of PSMC6 2 0.41 0 0
122 INT155591 Binding of PSME1 2 0.07 0.49 0
123 INT285901 Regulation of Transcription of CDK2 1 0.03 0.7 0
124 INT289866 Protein_catabolism of CDK1 1 0.46 0 0
125 INT230109 Positive_regulation of Gene_expression of BUB1B 1 0.42 0.65 0
126 INT289873 Negative_regulation of Gene_expression of CCNB1 1 0.15 0 0
127 INT248587 Positive_regulation of Gene_expression of PSMD3 1 0.04 0.16 0
128 INT166205 Negative_regulation of Gene_expression of PSME1 1 0.18 0.28 0
129 INT222070 Localization of PSMD3 1 0.04 0.09 0
130 INT302263 Regulation of Phosphorylation of PSMD6 1 0.09 0.84 0
131 INT209457 Negative_regulation of Gene_expression of PSMD1 1 0.27 0.2 0
132 INT175213 Negative_regulation of Binding of UBC 1 0.02 0.13 0
133 INT157670 Regulation of PSMC6 1 0.44 0.58 0
134 INT245611 Positive_regulation of Binding of PSMD2 1 0.43 0.1 0
135 INT276616 Binding of UBE2S 1 0.01 0.25 0
136 INT289863 Negative_regulation of Positive_regulation of CDK1 1 0.31 0 0
137 INT156902 Positive_regulation of UBC 1 0.49 0 0
138 INT289864 Positive_regulation of CCNB1 1 0.25 0 0
139 INT341855 Positive_regulation of Positive_regulation of CDK2 1 0.06 0.51 0
140 INT289862 Positive_regulation of Gene_expression of CDK1 1 0.26 0 0
141 INT289859 Localization of CCNB1 1 0.24 0.27 0
142 INT302249 Positive_regulation of Phosphorylation of PSMD6 1 0.10 0.84 0
143 INT289620 Regulation of Binding of CDK2 1 0.28 0.22 0
144 INT186659 Regulation of Protein_catabolism of PSMB9 1 0.15 0.17 0
145 INT289869 Positive_regulation of Protein_catabolism of CDK1 1 0.26 0 0
146 INT177818 Positive_regulation of PSMB6 1 0.19 0.25 0
147 INT214218 Negative_regulation of PSMD6 1 0.01 0 0
148 INT302251 Phosphorylation of PSMD6 1 0.17 0.84 0
149 INT155592 Positive_regulation of Binding of PSME1 1 0.09 0.1 0
150 INT289860 Negative_regulation of Positive_regulation of CCNB1 1 0.15 0 0
151 INT280550 Regulation of Gene_expression of PSMB9 1 0.57 0.37 0
152 INT343564 Regulation of Gene_expression of PSMD6 1 0.44 0.35 0
153 INT235469 Positive_regulation of Gene_expression of SKP2 1 0.26 1.24 0
154 INT287280 Positive_regulation of Negative_regulation of PSMD1 1 0.10 0 0
155 INT289871 Positive_regulation of Gene_expression of CCNB1 1 0.25 0.41 0
156 INT166206 Regulation of Gene_expression of PSME1 1 0.19 0.28 0
157 INT175222 Binding of UBC 1 0.02 0.54 0
158 INT325169 Regulation of Negative_regulation of CDK2 1 0.34 0.05 0
159 INT209458 Negative_regulation of Gene_expression of PSMD2 1 0.23 0.2 0
160 INT261736 Gene_expression of PSMB6 1 0.01 0 0
161 INT225187 Positive_regulation of Binding of CDK2 1 0.56 0.87 0
162 INT186626 Protein_catabolism of PSMB6 1 0.16 0.17 0
163 INT268300 Gene_expression of Cdc20 1 0.37 0.25 0
164 INT252986 Regulation of Transcription of PTTG1 1 0.11 0.42 0
165 INT252983 Negative_regulation of Positive_regulation of PTTG1 1 0.17 0.89 0
166 INT252990 Phosphorylation of PTTG1 1 0.33 0.35 0
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