GO:0031214

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Name biomineral tissue development
Categary Process
Go Slim No
Go Link GO:0031214
Unique Molecular Interactions 196
Total Molecular Interactions 264
Total Single Events 2076
Pain Genes Associated 23

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for biomineral tissue development. They are ordered first by their pain relevance and then by number of times they were reported for biomineral tissue development. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT250867 Fgf8 Positive_regulation of Protein_catabolism of Ecm1 1 0.06 4.35 2.14
2 INT342993 PHEX Regulation of Protein_catabolism of SFTPA1 1 0.00 2.84 1.58
3 INT291964 Phex Regulation of Gene_expression of Grin2b 1 0.08 1.39 1.04
4 INT136795 Spp1 Positive_regulation of Chuk 1 0.11 1.54 0.77
5 INT107602 Binding of OPLL and Enpp1 1 0.15 1.12 0.76
6 INT185802 Binding of MMP7 and SPP1 1 0.33 1.71 0.68
7 INT250871 Il1a Positive_regulation of Protein_catabolism of Ecm1 1 0.01 1.44 0.68
8 INT102863 Prkaca Regulation of Srgn 1 0.50 0.05 0.64
9 INT179850 Binding of Ecm1 and Il11 1 0.02 0 0.6
10 INT185809 Binding of PDX1 and SPP1 1 0.02 1.69 0.57
11 INT250852 Fgf8 Negative_regulation of Gene_expression of Ecm1 1 0.04 1.1 0.54
12 INT185800 SPP1 Negative_regulation of Gene_expression of MMP1 1 0.26 1.03 0.49
13 INT250858 Mmp3 Regulation of Protein_catabolism of Ecm1 1 0.01 1.11 0.47
14 INT183322 Binding of CNNM4 and RBM4B 1 0.12 0.59 0.46
15 INT225775 Enpp1 Positive_regulation of Ppi-rs 1 0.06 2.49 0.44
16 INT355540 Gnptg Positive_regulation of AMELX 1 0.00 2.16 0.44
17 INT291963 Phex Negative_regulation of Gene_expression of Grin1 1 0.06 0.81 0.43
18 INT291965 Phex Negative_regulation of Pag1 1 0.05 0.82 0.43
19 INT346527 Binding of PTH2R and TFIP11 1 0.18 0.11 0.42
20 INT260744 Binding of Ecm1 and Tlr2 1 0.00 0.45 0.39
21 INT20949 Binding of HTN1 and PC 1 0.27 0 0.38
22 INT260746 Binding of TLR4 and Ecm1 1 0.02 0.44 0.38
23 INT185811 SPP1 Positive_regulation of MMP3 1 0.14 0.83 0.38
24 INT185814 Binding of MMP3 and SPP1 1 0.15 0.83 0.38
25 INT250870 Fgf8 Positive_regulation of Ecm1 1 0.04 0.79 0.38
26 INT185804 MMP2 Positive_regulation of SPP1 1 0.15 0.88 0.37
27 INT185795 MMP7 Positive_regulation of SPP1 1 0.38 0.81 0.37
28 INT185798 SPP1 Positive_regulation of Gene_expression of MMP2 1 0.26 0.87 0.37
29 INT185807 SPP1 Positive_regulation of MMP7 1 0.56 0.79 0.36
30 INT133307 Binding of CD44 and SPP1 5 0.26 2.6 0.35
31 INT206609 Binding of Col7a1 and Ecm1 1 0.00 0.47 0.33
32 INT206608 Binding of Ecm1 and Itgb5 1 0.02 0.41 0.33
33 INT242995 Agt Positive_regulation of Spp1 1 0.36 1.82 0.33
34 INT44127 Agt Negative_regulation of DSPP 1 0.02 0 0.32
35 INT223962 Tnf Negative_regulation of Gene_expression of Bglap 1 0.21 1.21 0.32
36 INT223964 Tnf Negative_regulation of Bglap 1 0.21 1.2 0.32
37 INT282420 Spp1 Positive_regulation of Ins1 1 0.20 1.25 0.32
38 INT127974 RAX2 Positive_regulation of SPP1 1 0.03 1.49 0.31
39 INT140386 Spp1 Positive_regulation of NFKB1 1 0.21 1.29 0.3
40 INT140385 Spp1 Negative_regulation of FOXO3 1 0.04 1.29 0.3
41 INT334499 Binding of AMELX and IL4 1 0.12 0.47 0.29
42 INT185799 Binding of EGFR and SPP1 1 0.19 0.64 0.29
43 INT185813 Binding of MMP7 and Positive_regulation of SPP1 1 0.46 0.85 0.28
44 INT185818 SPP1 Positive_regulation of Gene_expression of COL7A1 1 0.10 0.82 0.28
45 INT225776 Enpp1 Positive_regulation of Positive_regulation of Ppi-rs 1 0.08 1.67 0.28
46 INT223965 Binding of AMY2A and Bglap 1 0.05 1.5 0.28
47 INT225784 Il1 Negative_regulation of Gene_expression of Enpp1 1 0.08 0.99 0.28
48 INT344402 Binding of Crp and Spp1 1 0.05 2.92 0.28
49 INT346196 AMELX Negative_regulation of CRP 1 0.04 0.36 0.26
50 INT346195 AMELX Negative_regulation of ESR1 1 0.02 0.36 0.26
51 INT242991 Agt Positive_regulation of Gene_expression of Spp1 1 0.21 0.66 0.26
52 INT136798 Spp1 Regulation of Gene_expression of PTGS2 1 0.08 0.65 0.24
53 INT329311 Spp1 Positive_regulation of IFN1@ 1 0.20 1.2 0.23
54 INT329306 Spp1 Positive_regulation of Il12a 1 0.08 1.19 0.23
55 INT299155 Smcp Negative_regulation of Spp1 1 0.00 0.7 0.22
56 INT180670 Cpd Regulation of Protein_catabolism of Ecm1 1 0.04 0.14 0.22
57 INT242994 Adipoq Negative_regulation of Spp1 1 0.19 0.59 0.21
58 INT319971 App Regulation of Enpp1 1 0.02 0.72 0.21
59 INT329310 Spp1 Positive_regulation of Gene_expression of IFN1@ 1 0.48 0.88 0.19
60 INT336892 Positive_regulation of Epc2 Positive_regulation of Localization of Spp1 1 0.00 0.62 0.19
61 INT336890 Positive_regulation of Epc2 Positive_regulation of Spp1 1 0.00 0.62 0.19
62 INT185805 SPP1 Regulation of MMP7 1 0.25 0.38 0.19
63 INT329309 Spp1 Regulation of Gene_expression of IFN1@ 1 0.26 0.82 0.19
64 INT185816 SPP1 Positive_regulation of Positive_regulation of MMP7 1 0.46 0.36 0.18
65 INT242993 Positive_regulation of Ppara Positive_regulation of Gene_expression of Spp1 1 0.24 0.66 0.18
66 INT185803 Binding of MMP11 and SPP1 1 0.06 0.34 0.17
67 INT185815 Binding of MMP1 and SPP1 1 0.21 0.34 0.17
68 INT346519 Binding of PTHLH and TFIP11 1 0.09 0.12 0.17
69 INT185810 Binding of MMP2 and SPP1 1 0.14 0.34 0.17
70 INT329305 Spp1 Positive_regulation of Gene_expression of Il12a 1 0.12 0.88 0.16
71 INT185808 SPP1 Positive_regulation of TIMP1 1 0.64 0.33 0.16
72 INT319974 App Negative_regulation of Enpp1 1 0.02 0.58 0.16
73 INT185793 SPP1 Positive_regulation of COL1A2 1 0.16 0.33 0.16
74 INT118257 Binding of ENPP1 and SUGT1 1 0.00 0.87 0.16
75 INT259628 Cxcl10 Positive_regulation of Protein_catabolism of Ecm1 1 0.00 0.64 0.15
76 INT319972 App Negative_regulation of Gene_expression of Enpp1 1 0.02 1.87 0.15
77 INT223963 Binding of Bglap and Runx2 1 0.14 1.74 0.13
78 INT250857 Gene_expression of Mmp3 Positive_regulation of Protein_catabolism of Ecm1 1 0.01 0.17 0.13
79 INT225783 Enpp1 Regulation of Ppi-rs 1 0.07 0.68 0.13
80 INT328384 Ghrl Positive_regulation of ALPL 1 0.01 0.93 0.13
81 INT329304 Spp1 Negative_regulation of Gene_expression of Il10 1 0.06 0.93 0.13
82 INT250869 Mia Positive_regulation of Protein_catabolism of Ecm1 1 0.01 0.25 0.12
83 INT180567 HEYL Regulation of Positive_regulation of IBSP 1 0.01 0.18 0.12
84 INT289793 Binding of Comp and Ecm1 1 0.05 2.5 0.12
85 INT238036 Binding of ENPP1 and OPLL 1 0.27 0.66 0.12
86 INT88937 Mmv7 Regulation of Gene_expression of SPP1 1 0.00 1.24 0.12
87 INT329303 Spp1 Positive_regulation of Localization of Il12a 1 0.12 0.92 0.12
88 INT346530 Binding of PTH1R and TFIP11 1 0.15 0 0.11
89 INT81559 Amelx Positive_regulation of Positive_regulation of Mat2a 1 0.09 0.19 0.11
90 INT336632 Ecm1 Regulation of Regulation of Ahr 1 0.03 0.61 0.11
91 INT320768 Spp1 Regulation of Protein_catabolism of Dsg1a 1 0.08 0.77 0.11
92 INT264838 Binding of Eno2 and Spp1 1 0.00 0.17 0.1
93 INT184537 Ccl2 Positive_regulation of Spp1 1 0.34 1.37 0.09
94 INT324829 ROS1 Positive_regulation of Gene_expression of Ecm1 1 0.00 0.66 0.09
95 INT348686 Plg Positive_regulation of Protein_catabolism of Ecm1 1 0.02 0.17 0.09
96 INT324828 ELANE Positive_regulation of Localization of Ecm1 1 0.00 0.61 0.09
97 INT184538 Positive_regulation of Ccl2 Positive_regulation of Spp1 1 0.34 1.38 0.09
98 INT88137 Ren Regulation of Gene_expression of Spp1 1 0.04 0.24 0.09
99 INT109464 Dmp1 Negative_regulation of Tyr 1 0.04 0 0.09
100 INT185644 Binding of STATH and WASF1 1 0.00 0 0.09
101 INT336634 Fbln1 Positive_regulation of Ecm1 1 0.06 1.26 0.09
102 INT45359 Spp1 Positive_regulation of Positive_regulation of Prl 1 0.21 0.23 0.09
103 INT184539 Spp1 Positive_regulation of Gpbar1 1 0.03 1.37 0.09
104 INT225805 Binding of SNRNP70 and Enpp1 1 0.42 1.43 0.09
105 INT180561 HEYL Negative_regulation of IBSP 1 0.01 0.19 0.09
106 INT109465 Dmp1 Positive_regulation of Insrr 1 0.00 0 0.08
107 INT226044 Lta Positive_regulation of Ecm1 1 0.02 0.44 0.08
108 INT259622 Elane Positive_regulation of Protein_catabolism of Ecm1 1 0.00 0.38 0.08
109 INT289711 Binding of F2 and Spp1 1 0.08 0.21 0.08
110 INT304330 TGFB1 Positive_regulation of ECM1 1 0.00 0.31 0.08
111 INT205158 Gene_expression of SPP1 Positive_regulation of Gene_expression of TNFSF11 1 0.11 1.08 0.08
112 INT269508 Binding of HTN1 and CFP 1 0.00 0 0.08
113 INT289710 F2 Regulation of Spp1 1 0.04 0 0.08
114 INT179847 Binding of Ecm1 and Sparc 1 0.04 0 0.08
115 INT269510 Binding of HTN1 and fc 1 0.00 0 0.07
116 INT133306 Positive_regulation of Binding of CD44 and SPP1 1 0.16 0.83 0.07
117 INT225781 Ppi-rs Positive_regulation of Gene_expression of Spp1 1 0.03 1 0.07
118 INT179852 Binding of PTPRC and Ecm1 1 0.00 0 0.05
119 INT180344 CYP2A6 Regulation of AMELX 1 0.01 2.01 0.05
120 INT226043 Epo Positive_regulation of Ecm1 1 0.04 1.35 0.05
121 INT205154 Binding of MMP9 and SPP1 1 0.25 0.45 0.05
122 INT225790 Il1 Regulation of Gene_expression of Enpp1 1 0.07 0.43 0.05
123 INT180667 Edn1 Regulation of Ecm1 1 0.04 0 0.05
124 INT329015 Binding of APCS and SRGN 1 0.08 1.14 0.04
125 INT346518 TFIP11 Regulation of PTH2R 1 0.23 0 0.04
126 INT225808 SNRNP70 Regulation of Enpp1 1 0.30 0.71 0.04
127 INT179836 Il11 Regulation of Gene_expression of Ecm1 1 0.05 0 0.04
128 INT247768 Fcer2a Positive_regulation of Enpp1 1 0.00 0.29 0.04
129 INT256578 Bglap Positive_regulation of Gene_expression of Ins1 1 0.38 0.43 0.04
130 INT256571 Bglap Positive_regulation of Localization of Ins1 1 0.53 0.25 0.04
131 INT256570 Bglap Positive_regulation of Gene_expression of Gck 1 0.48 0.43 0.04
132 INT225791 Ppi-rs Positive_regulation of Spp1 1 0.02 0.49 0.04
133 INT256577 Bglap Regulation of Localization of Ins1 1 0.47 0.44 0.04
134 INT336639 PTPRC Positive_regulation of Ecm1 1 0.00 0.62 0.04
135 INT256575 Bglap Positive_regulation of Gene_expression of Gopc 1 0.20 0.43 0.04
136 INT219230 Binding of Ecm1 and Ighv10-3 1 0.00 0.26 0.04
137 INT225801 Binding of Enpp1 and Npp 1 0.17 0.46 0.04
138 INT225800 Binding of Insr and Enpp1 1 0.05 0.67 0.04
139 INT327451 HTN1 Positive_regulation of Adra1a 1 0.00 1.36 0.03
140 INT176549 Mtv7 Positive_regulation of Spp1 1 0.26 0.86 0.03
141 INT225802 Binding of Enpp1 and Ppi-rs 1 0.04 1 0.03
142 INT176540 Pik3cd Positive_regulation of Spp1 1 0.11 1.8 0.03
143 INT301408 Positive_regulation of Binding of Enpp1 and Twist1 1 0.06 0.18 0.03
144 INT301406 Binding of Enpp1 and Twist1 1 0.04 0.18 0.03
145 INT176543 Binding of Cd44 and Spp1 2 0.31 0.57 0
146 INT320766 Spp1 Negative_regulation of Dsg1a 1 0.11 1.05 0
147 INT186502 Binding of AMELX and HLA-A 1 0.00 0.71 0
148 INT176548 Gopc Regulation of Gene_expression of Spp1 1 0.12 0 0
149 INT176538 Mapk1 Positive_regulation of Gene_expression of Spp1 1 0.12 0.43 0
150 INT309836 Binding of Cd8a and Dmp1 1 0.00 0.7 0
151 INT205159 SPP1 Positive_regulation of Gene_expression of TNFSF11 1 0.11 0.8 0
152 INT176551 Binding of Pik3r1 and Spp1 1 0.03 0.65 0
153 INT318544 Paics Regulation of Ecm1 1 0.00 1.43 0
154 INT344401 Agtr2 Positive_regulation of Gene_expression of Spp1 1 0.01 3.21 0
155 INT176534 Mapk14 Positive_regulation of Spp1 1 0.14 0.42 0
156 INT292088 Binding of AMELX and ANGPT1 1 0.00 0.9 0
157 INT176554 Ass1 Positive_regulation of Gene_expression of Spp1 1 0.01 1.26 0
158 INT346520 Binding of TPM3 and TFIP11 1 0.06 0 0
159 INT185796 SPP1 Regulation of Gene_expression of COL7A1 1 0.06 0 0
160 INT179848 Binding of Ecm1 and Gtf3a 1 0.00 0.19 0
161 INT158027 Binding of alp and Bglap 1 0.32 0 0
162 INT210581 Binding of AMELX and Tnfsf11 1 0.01 0.15 0
163 INT222474 Binding of Fgf1 and Ecm1 1 0.00 0.62 0
164 INT180672 Sgk1 Regulation of Ecm1 1 0.03 0 0
165 INT180349 Binding of AMELX and BTG3 1 0.00 0.56 0
166 INT185817 SPP1 Positive_regulation of Gene_expression of TIMP1 1 0.64 0 0
167 INT158026 Regulation of Binding of alp and Bglap 1 0.39 0 0
168 INT266837 Dmp1 Negative_regulation of Gene_expression of Fgf23 1 0.48 2.41 0
169 INT346521 Binding of PTH and TFIP11 1 0.10 0 0
170 INT205153 Gene_expression of SPP1 Regulation of Localization of MMP9 1 0.14 0.57 0
171 INT176555 Ass1 Positive_regulation of Spp1 1 0.01 0 0
172 INT255385 Binding of COL1A2 and DSPP 1 0.40 0.12 0
173 INT205150 SPP1 Positive_regulation of Positive_regulation of MMP9 1 0.21 0 0
174 INT185801 SPP1 Regulation of Gene_expression of TIMP1 1 0.25 0 0
175 INT185794 SPP1 Regulation of Gene_expression of MMP1 1 0.16 0 0
176 INT290679 Binding of SPP1 and KRTAP19-9P 1 0.05 1.2 0
177 INT351678 Nrp1 Regulation of Binding of Ecm1 1 0.00 1.55 0
178 INT344405 Binding of EGFR and Spp1 1 0.09 1.34 0
179 INT301401 Binding of Enpp1 and Enpp2 1 0.23 0.54 0
180 INT185812 SPP1 Negative_regulation of MMP1 1 0.26 0 0
181 INT225782 Tnfrsf11b Regulation of Enpp1 1 0.12 0.74 0
182 INT176550 Pik3r1 Positive_regulation of Gene_expression of Spp1 1 0.05 0.47 0
183 INT176556 Binding of Mapk14 and Positive_regulation of Gene_expression of Spp1 1 0.14 0.43 0
184 INT290675 SPP1 Positive_regulation of Gene_expression of VEGFA 1 0.16 2.37 0
185 INT176544 Mapk14 Positive_regulation of Transcription of Spp1 1 0.20 0.42 0
186 INT256572 Bglap Regulation of Gene_expression of Ins1 1 0.47 0.44 0
187 INT351681 Binding of Ecm1 and Fn1 1 0.00 1.14 0
188 INT256579 Negative_regulation of Bglap Negative_regulation of Localization of Ins1 1 0.33 0.38 0
189 INT355541 Binding of AMELX and Tnfrsf25 1 0.00 1.36 0
190 INT355522 Binding of AMELX and HLA-DRB7 1 0.00 1.35 0
191 INT293410 HRAS Regulation of Localization of SPP1 1 0.00 0.8 0
192 INT180673 Trib3 Regulation of Ecm1 1 0.02 0 0
193 INT266833 Phex Regulation of Gene_expression of Fgf23 1 0.23 0.46 0
194 INT255517 Binding of PHEX and GP6 1 0.05 0.18 0
195 INT176541 Mapk1 Positive_regulation of Spp1 1 0.13 0.42 0
196 INT176547 Mapk1 Positive_regulation of Transcription of Spp1 1 0.18 0.42 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for biomineral tissue development. They are ordered first by their pain relevance and then by number of times they were reported in biomineral tissue development. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT110427 Gene_expression of Spp1 199 0.78 176.11 23.31
2 INT37541 Gene_expression of SPP1 113 0.77 68.54 11.35
3 INT8021 Gene_expression of Enpp1 43 0.78 31.46 10.8
4 INT122901 Positive_regulation of Spp1 67 0.67 58.03 7.49
5 INT134967 Gene_expression of Ecm1 66 0.29 38.4 7.16
6 INT110599 Gene_expression of Bglap 49 0.74 41.23 6.97
7 INT171691 Protein_catabolism of Ecm1 31 0.20 11.57 6.38
8 INT122902 Positive_regulation of Gene_expression of Spp1 54 0.70 56.3 6.33
9 INT6913 Negative_regulation of Amelx 6 0.32 2.32 5.95
10 INT224530 Positive_regulation of Enpp1 12 0.70 7.03 5.82
11 INT179810 Protein_catabolism of Ecm1 30 0.11 18.28 5.75
12 INT88935 Positive_regulation of SPP1 36 0.70 31.07 5.49
13 INT102855 Negative_regulation of Srgn 8 0.57 0.91 4.63
14 INT134968 Localization of Ecm1 20 0.32 27.27 4.31
15 INT97128 Localization of SPP1 32 0.80 21.75 4.02
16 INT223949 Transcription of Bglap 1 0.68 19.96 3.98
17 INT92678 Positive_regulation of Ecm1 30 0.09 28.41 3.68
18 INT132187 Gene_expression of Ecm1 14 0.21 8.12 3.52
19 INT171233 Binding of Ecm1 25 0.07 12.41 3.36
20 INT136791 Negative_regulation of Spp1 24 0.59 23.6 3.33
21 INT68445 Gene_expression of ENPP1 10 0.70 10.8 3.3
22 INT88130 Gene_expression of Spp1 13 0.74 12.96 3.07
23 INT207851 Regulation of Enpp1 5 0.45 4.42 2.96
24 INT136964 Gene_expression of Dmp1 10 0.75 3.69 2.83
25 INT102856 Positive_regulation of Srgn 7 0.61 1.27 2.54
26 INT134964 Regulation of Ecm1 13 0.10 7.45 2.37
27 INT160080 Localization of Ecm1 6 0.15 4.86 2.36
28 INT176517 Negative_regulation of Gene_expression of Spp1 18 0.59 15.31 2.28
29 INT27590 Negative_regulation of Phex 5 0.36 2.38 2.26
30 INT107597 Binding of Enpp1 5 0.37 3.35 2.23
31 INT176510 Binding of Spp1 21 0.42 22.1 2
32 INT316778 Positive_regulation of Gene_expression of ENPP1 1 0.62 7.2 1.97
33 INT176516 Localization of Spp1 28 0.76 19.39 1.9
34 INT224529 Positive_regulation of Gene_expression of Enpp1 15 0.70 12.75 1.81
35 INT6912 Positive_regulation of Binding of Amelx 1 0.34 0.13 1.81
36 INT131916 Negative_regulation of ALPL 10 0.42 9.33 1.8
37 INT6911 Binding of Amelx 1 0.26 0.13 1.79
38 INT183331 Gene_expression of CNNM4 1 0.53 12.03 1.78
39 INT223959 Localization of Bglap 10 0.77 11.25 1.74
40 INT102857 Phosphorylation of Srgn 1 0.72 0.26 1.71
41 INT134965 Negative_regulation of Ecm1 7 0.18 7.86 1.7
42 INT210694 Localization of Amelx 2 0.35 0.75 1.66
43 INT133311 Binding of SPP1 10 0.37 9.47 1.65
44 INT180678 Negative_regulation of Protein_catabolism of Ecm1 6 0.08 2.69 1.61
45 INT181316 Positive_regulation of ALPL 5 0.65 1.65 1.6
46 INT89849 Regulation of Srgn 6 0.30 0.93 1.59
47 INT88136 Positive_regulation of Gene_expression of Spp1 8 0.66 4.5 1.57
48 INT332460 Regulation of Binding of Enpp1 1 0.05 0.78 1.5
49 INT88934 Regulation of SPP1 9 0.54 6.94 1.47
50 INT104250 Positive_regulation of Gene_expression of SPP1 17 0.69 13.22 1.44
51 INT159102 Regulation of Ecm1 9 0.16 1.28 1.41
52 INT2824 Positive_regulation of HTN1 10 0.40 10.41 1.4
53 INT88133 Positive_regulation of Spp1 8 0.66 10.07 1.33
54 INT102852 Negative_regulation of Phosphorylation of Srgn 1 0.52 0.17 1.32
55 INT50843 Positive_regulation of Phex 5 0.43 1.38 1.31
56 INT102853 Positive_regulation of Phosphorylation of Srgn 1 0.61 0.17 1.31
57 INT195060 Gene_expression of ALPL 9 0.73 4.82 1.3
58 INT119671 Gene_expression of IBSP 10 0.58 4.31 1.26
59 INT184303 Positive_regulation of Bglap 16 0.66 8.66 1.25
60 INT107599 Negative_regulation of Enpp1 8 0.51 6.02 1.24
61 INT184301 Negative_regulation of Bglap 16 0.56 11.22 1.22
62 INT158540 Negative_regulation of HTN1 4 0.34 7.25 1.22
63 INT145959 Negative_regulation of DSPP 19 0.57 2.75 1.21
64 INT116279 Binding of Dmp1 3 0.04 0 1.2
65 INT105571 Gene_expression of SRGN 33 0.58 14.68 1.19
66 INT223958 Positive_regulation of Transcription of Bglap 1 0.66 6.57 1.19
67 INT184314 Regulation of Gene_expression of Bglap 6 0.59 7.11 1.16
68 INT118258 Positive_regulation of ENPP1 3 0.62 4.26 1.16
69 INT158025 Regulation of Bglap 6 0.60 7.03 1.11
70 INT183334 Localization of CNNM4 1 0.55 1.19 1.08
71 INT158542 Gene_expression of HTN1 10 0.75 10.69 1.07
72 INT139465 Gene_expression of Amelx 4 0.61 0.81 1.07
73 INT180683 Positive_regulation of Protein_catabolism of Ecm1 9 0.09 2.25 1.03
74 INT184547 Localization of Spp1 4 0.58 4.44 1.02
75 INT89853 Gene_expression of Srgn 12 0.44 1.13 1
76 INT89128 Binding of DSPP 7 0.32 2.24 0.98
77 INT158541 Positive_regulation of Gene_expression of HTN1 3 0.40 5.88 0.97
78 INT102333 Positive_regulation of Dmp1 5 0.58 0 0.94
79 INT248774 Positive_regulation of Localization of Ecm1 4 0.05 8.46 0.92
80 INT242988 Positive_regulation of Transcription of Spp1 4 0.28 3.28 0.92
81 INT147880 Regulation of SRGN 28 0.33 13.99 0.9
82 INT179814 Positive_regulation of Protein_catabolism of Ecm1 5 0.06 3.38 0.85
83 INT151907 Binding of Ecm1 6 0.11 2.48 0.83
84 INT33097 Negative_regulation of PHEX 3 0.14 0.41 0.82
85 INT250847 Negative_regulation of Ecm1 1 0.03 1.72 0.78
86 INT176528 Regulation of Spp1 9 0.45 9.05 0.77
87 INT16003 Gene_expression of Phex 3 0.65 4.68 0.77
88 INT180361 Positive_regulation of AMELX 7 0.12 6.03 0.76
89 INT185838 Protein_catabolism of SPP1 1 0.65 1.68 0.74
90 INT95860 Regulation of Phex 1 0.00 0 0.69
91 INT176513 Transcription of Spp1 5 0.63 4.32 0.67
92 INT35098 Localization of Enpp1 4 0.75 0.81 0.67
93 INT171692 Regulation of Protein_catabolism of Ecm1 4 0.12 1.5 0.65
94 INT69283 Gene_expression of PHEX 25 0.75 7.81 0.64
95 INT117275 Localization of STATH 1 0.00 0 0.6
96 INT88933 Regulation of Gene_expression of SPP1 7 0.45 6.05 0.59
97 INT242987 Positive_regulation of Localization of Spp1 3 0.60 7.04 0.59
98 INT179337 Positive_regulation of Gene_expression of Ecm1 14 0.05 3.73 0.58
99 INT127975 Negative_regulation of SPP1 15 0.42 11.25 0.56
100 INT110319 Positive_regulation of SRGN 10 0.40 6.2 0.56
101 INT171693 Positive_regulation of Ecm1 5 0.09 2.14 0.55
102 INT132186 Negative_regulation of Gene_expression of Ecm1 2 0.06 1.73 0.54
103 INT183332 Binding of CNNM4 1 0.33 3.05 0.53
104 INT242208 Regulation of Gene_expression of SRGN 7 0.29 3.15 0.52
105 INT133314 Positive_regulation of Binding of SPP1 2 0.22 2.38 0.52
106 INT223954 Negative_regulation of Transcription of Bglap 1 0.41 2.7 0.49
107 INT81577 Regulation of ALPL 3 0.26 0.82 0.48
108 INT250837 Positive_regulation of Negative_regulation of Ecm1 1 0.04 1.1 0.44
109 INT116002 Protein_catabolism of Phex 1 0.06 0.45 0.44
110 INT223956 Regulation of Transcription of Bglap 1 0.43 1.4 0.44
111 INT223948 Negative_regulation of Gene_expression of Bglap 1 0.56 6.49 0.44
112 INT195058 Positive_regulation of Gene_expression of ALPL 3 0.65 1.56 0.42
113 INT69282 Binding of PHEX 4 0.15 1.43 0.41
114 INT127976 Negative_regulation of Regulation of SPP1 1 0.37 1.62 0.41
115 INT180353 Binding of AMELX 10 0.04 15.34 0.4
116 INT15589 Protein_catabolism of PHEX 3 0.21 0.76 0.4
117 INT225772 Regulation of Gene_expression of Enpp1 1 0.62 1.6 0.4
118 INT205725 Regulation of Regulation of Ecm1 1 0.03 0.1 0.4
119 INT195059 Phosphorylation of ALPL 1 0.77 0.79 0.4
120 INT6916 Binding of Phex 1 0.01 0 0.4
121 INT289704 Protein_catabolism of Spp1 5 0.27 2.42 0.39
122 INT15588 Regulation of PHEX 4 0.26 1.48 0.39
123 INT121141 Transcription of Spp1 6 0.34 5.02 0.38
124 INT180595 Regulation of IBSP 2 0.09 1.29 0.38
125 INT184304 Binding of Bglap 3 0.31 2.16 0.37
126 INT184312 Negative_regulation of Binding of Bglap 2 0.35 2.07 0.37
127 INT306349 Transcription of SRGN 1 0.20 2.36 0.36
128 INT346541 Positive_regulation of Gene_expression of TFIP11 1 0.32 0.91 0.36
129 INT176519 Regulation of Gene_expression of Spp1 7 0.58 8.54 0.35
130 INT329301 Phosphorylation of Spp1 1 0.62 1.71 0.34
131 INT250834 Negative_regulation of Localization of Ecm1 1 0.04 0.58 0.34
132 INT185830 Positive_regulation of Localization of SPP1 2 0.50 3.39 0.33
133 INT88134 Negative_regulation of Gene_expression of Spp1 2 0.41 1.94 0.32
134 INT66462 Positive_regulation of Negative_regulation of Phex 1 0.01 0.16 0.32
135 INT18234 Transcription of PHEX 2 0.52 0 0.31
136 INT346547 Gene_expression of TFIP11 1 0.43 0.84 0.3
137 INT144885 Gene_expression of AMELX 4 0.11 2.89 0.29
138 INT109156 Negative_regulation of ENPP1 2 0.34 1.34 0.29
139 INT16180 Regulation of DSPP 6 0.53 4.63 0.28
140 INT176518 Positive_regulation of Positive_regulation of Spp1 5 0.47 3.36 0.28
141 INT166755 Localization of PHEX 2 0.73 1.16 0.28
142 INT180362 Negative_regulation of AMELX 2 0.11 1.51 0.27
143 INT185828 Phosphorylation of SPP1 1 0.62 1.36 0.26
144 INT343565 Positive_regulation of Gene_expression of Ecm1 1 0.07 0.94 0.25
145 INT346535 Positive_regulation of TFIP11 1 0.39 0.75 0.25
146 INT167751 Gene_expression of DSPP 15 0.77 8.56 0.24
147 INT254818 Positive_regulation of Positive_regulation of Ecm1 4 0.06 5.27 0.24
148 INT248262 Negative_regulation of Positive_regulation of Spp1 1 0.04 0.65 0.24
149 INT97129 Transcription of SPP1 4 0.51 0.67 0.23
150 INT185826 Negative_regulation of Gene_expression of SPP1 1 0.42 0.8 0.23
151 INT88131 Negative_regulation of Spp1 3 0.56 0.7 0.21
152 INT180352 Regulation of AMELX 1 0.03 4.02 0.21
153 INT180584 Positive_regulation of IBSP 1 0.16 0.37 0.21
154 INT141306 Binding of Srgn 1 0.30 0.23 0.21
155 INT129762 Binding of HTN1 5 0.03 5.68 0.19
156 INT171231 Regulation of Binding of Ecm1 2 0.06 0.2 0.19
157 INT193312 Localization of DSPP 8 0.74 1.88 0.18
158 INT89851 Localization of Srgn 1 0.58 0.15 0.18
159 INT89850 Positive_regulation of Localization of Srgn 1 0.36 0.15 0.18
160 INT176522 Negative_regulation of Localization of Spp1 3 0.37 2.65 0.17
161 INT254804 Negative_regulation of Protein_catabolism of Ecm1 2 0.04 0.97 0.17
162 INT50842 Positive_regulation of Positive_regulation of Phex 1 0.31 0 0.17
163 INT351417 Regulation of Protein_catabolism of Ecm1 1 0.00 0.98 0.17
164 INT223946 Positive_regulation of Localization of Bglap 1 0.48 1.25 0.17
165 INT180586 Transcription of IBSP 1 0.16 0.27 0.17
166 INT26001 Localization of Phex 1 0.03 0 0.17
167 INT89857 Regulation of Gene_expression of Srgn 1 0.20 0.17 0.17
168 INT180594 Localization of ECM1 1 0.07 0.5 0.17
169 INT142732 Negative_regulation of STATH 3 0.42 1.72 0.16
170 INT193311 Transcription of DSPP 1 0.02 0.47 0.16
171 INT175900 Regulation of ENPP1 1 0.00 1.96 0.16
172 INT252419 Phosphorylation of Enpp1 1 0.08 0.21 0.16
173 INT346540 Binding of TFIP11 1 0.31 0 0.15
174 INT110105 Positive_regulation of Localization of Dmp1 1 0.48 0 0.14
175 INT319407 Positive_regulation of Transcription of STATH 1 0.40 0.69 0.14
176 INT319441 Transcription of STATH 1 0.58 0.69 0.14
177 INT110103 Negative_regulation of Dmp1 1 0.41 0 0.14
178 INT110098 Negative_regulation of Localization of Dmp1 1 0.41 0 0.14
179 INT225771 Negative_regulation of Gene_expression of Enpp1 4 0.43 3.68 0.13
180 INT110101 Localization of Dmp1 1 0.71 0 0.13
181 INT290471 Positive_regulation of Transcription of ECM1 1 0.04 1.56 0.12
182 INT290469 Transcription of ECM1 1 0.04 1.55 0.12
183 INT88936 Positive_regulation of Regulation of SPP1 1 0.40 1.1 0.11
184 INT293903 Localization of HTN1 2 0.10 0.98 0.1
185 INT171221 Regulation of Gene_expression of Ecm1 1 0.06 0.08 0.1
186 INT218593 Regulation of Gene_expression of Ecm1 1 0.04 1.49 0.1
187 INT297993 Negative_regulation of ECM1 1 0.01 0.31 0.09
188 INT109463 Regulation of Dmp1 1 0.16 0 0.09
189 INT280055 Positive_regulation of Gene_expression of SRGN 5 0.42 2.49 0.08
190 INT117827 Positive_regulation of PHEX 3 0.41 1.59 0.08
191 INT179824 Regulation of Transcription of Ecm1 1 0.08 0 0.08
192 INT223957 Negative_regulation of Regulation of Bglap 1 0.41 1.47 0.08
193 INT144708 Regulation of Gene_expression of Spp1 1 0.04 0.32 0.08
194 INT179790 Transcription of Ecm1 1 0.10 0 0.08
195 INT184552 Regulation of Spp1 1 0.17 1.55 0.08
196 INT254792 Regulation of Positive_regulation of Ecm1 2 0.06 1.86 0.07
197 INT142770 Positive_regulation of Gene_expression of Bglap 1 0.11 0.08 0.07
198 INT175644 Positive_regulation of Gene_expression of IBSP 6 0.23 3.95 0.06
199 INT207722 Localization of IBSP 4 0.22 2.19 0.06
200 INT320271 Positive_regulation of Localization of IBSP 1 0.02 1.06 0.06
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