GO:0031224

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Name intrinsic to membrane
Categary Component
Go Slim No
Go Link GO:0031224
Unique Molecular Interactions 128
Total Molecular Interactions 216
Total Single Events 950
Pain Genes Associated 10

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for intrinsic to membrane. They are ordered first by their pain relevance and then by number of times they were reported for intrinsic to membrane. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT215096 Binding of Hmgb1 and Tlr2 9 0.38 11.61 1.61
2 INT229094 Binding of IL1RN and Il1r1 1 0.01 1.9 1.5
3 INT115985 Cpe Positive_regulation of Binding of Gnas 1 0.00 0.17 1.28
4 INT130627 Gnas Regulation of Prkaca 1 0.00 0 1.13
5 INT276964 Binding of Tlr1 and Tlr2 11 0.24 4.22 0.89
6 INT276988 Binding of Tlr6 and Tlr2 11 0.26 4.89 0.79
7 INT128684 Binding of TGM1 and RETNLB 1 0.00 2.46 0.72
8 INT123869 Binding of GNAS and OPRK1 1 0.00 0.37 0.7
9 INT237907 Tlr4 Positive_regulation of Gene_expression of Tlr2 7 0.40 5.85 0.6
10 INT229095 Binding of IL1R1 and Il1r1 1 0.00 0.64 0.5
11 INT179507 Tlr4 Positive_regulation of Tlr2 2 0.17 1.07 0.49
12 INT246938 Binding of Tlr4 and Tlr2 3 0.39 2.88 0.46
13 INT174699 Binding of Tlr2 and Tlr3 3 0.14 0.66 0.35
14 INT310765 Binding of Pam and Tlr2 1 0.01 0.57 0.35
15 INT288200 Tlr2 Positive_regulation of Pik3r1 1 0.05 0.24 0.33
16 INT224681 Tlr2 Positive_regulation of Gene_expression of Il15 1 0.01 0.66 0.33
17 INT226512 Il1rl1 Positive_regulation of Jun 1 0.12 0.34 0.29
18 INT226505 Il1rl1 Positive_regulation of Mapk8 1 0.04 0.4 0.29
19 INT226509 Il1rl1 Positive_regulation of Gene_expression of Mapk8 1 0.05 0.4 0.29
20 INT276953 Positive_regulation of Tlr2 Positive_regulation of Phosphorylation of Stat3 1 0.38 0.93 0.27
21 INT276979 Positive_regulation of Tlr2 Positive_regulation of Gene_expression of Stat3 1 0.38 0.93 0.27
22 INT296794 Positive_regulation of Tlr2 Positive_regulation of Pik3r1 1 0.10 1.02 0.26
23 INT276974 Tlr2 Positive_regulation of Gene_expression of Ccr8 1 0.27 0.16 0.24
24 INT276952 Tlr2 Positive_regulation of Localization of Hspd1 1 0.25 0.16 0.24
25 INT140376 TGM1 Positive_regulation of Rhoa 1 0.01 0 0.24
26 INT70082 Binding of APP and TGM1 1 0.00 1.22 0.22
27 INT266380 Binding of Tlr2 and Il1 1 0.01 0.76 0.21
28 INT254219 Binding of Myd88 and Tlr2 2 0.16 0.6 0.2
29 INT348032 Fndc3b Positive_regulation of Tlr2 1 0.01 1.3 0.2
30 INT258289 Hmgb1 Positive_regulation of Tlr2 4 0.48 3.61 0.19
31 INT339503 Tlr2 Positive_regulation of Eif2ak2 1 0.12 0.09 0.19
32 INT121632 PTGER1 Positive_regulation of TGM1 1 0.00 0.67 0.19
33 INT121631 PDGFD Positive_regulation of TGM1 1 0.01 0.68 0.18
34 INT195114 Gene_expression of Il1r1 Positive_regulation of Positive_regulation of F2r 1 0.38 1.67 0.18
35 INT276946 Hspd1 Positive_regulation of Tlr2 2 0.37 1.01 0.17
36 INT324820 Hsp90b1 Positive_regulation of Tlr2 1 0.16 0.42 0.17
37 INT148563 Ngf Positive_regulation of GNAS 1 0.06 0.07 0.16
38 INT204789 Binding of Tlr2 and Nod2 1 0.23 0.44 0.16
39 INT226527 Il1rl1 Positive_regulation of Gene_expression of IK 1 0.00 0.42 0.15
40 INT276958 Binding of Tlr2 and Clec7a 1 0.09 0.58 0.15
41 INT226507 Il1rl1 Positive_regulation of Gene_expression of Jun 1 0.13 0.2 0.15
42 INT226518 Il1rl1 Positive_regulation of MAPK14 1 0.04 0.2 0.15
43 INT228216 Positive_regulation of Mapk14 Regulation of Gene_expression of Tlr2 1 0.09 1.11 0.15
44 INT70090 TGM1 Positive_regulation of Binding of Ache 1 0.03 0.59 0.15
45 INT324874 Positive_regulation of Tlr2 Positive_regulation of Gene_expression of Mif 1 0.05 0.66 0.15
46 INT324860 Tlr2 Positive_regulation of Gene_expression of Mif 1 0.05 0.66 0.15
47 INT226520 Il1rl1 Positive_regulation of Gene_expression of MAPK14 1 0.03 0.2 0.15
48 INT333273 Tlr1 Positive_regulation of Localization of Ccl20 1 0.23 0.16 0.14
49 INT276948 Tlr2 Negative_regulation of Gene_expression of Tlr4 1 0.25 1.06 0.14
50 INT333270 Tlr2 Positive_regulation of Localization of Ccl20 1 0.24 0.16 0.14
51 INT226516 Il1rl1 Positive_regulation of Phosphorylation of Jun 1 0.02 0.19 0.14
52 INT348040 TNF Positive_regulation of Gene_expression of Tlr2 1 0.02 0.98 0.14
53 INT276950 Hspd1 Positive_regulation of Positive_regulation of Tlr2 1 0.22 1.25 0.13
54 INT325272 Il1rl1 Positive_regulation of Gene_expression of TNF 1 0.02 0.41 0.12
55 INT325268 Il1rl1 Positive_regulation of Gene_expression of Spg21 1 0.05 0.41 0.12
56 INT345280 Binding of Tlr2 and Tlr7 1 0.05 0.49 0.12
57 INT324691 Tlr6 Positive_regulation of Rcvrn 1 0.01 0 0.12
58 INT324695 Tlr6 Positive_regulation of Tlr2 1 0.14 0 0.12
59 INT70084 Negative_regulation of Binding of APP and TGM1 1 0.00 0.61 0.11
60 INT300545 Il6 Positive_regulation of Gene_expression of Il1r1 1 0.02 0.42 0.11
61 INT70083 TGM1 Positive_regulation of Binding of APP 1 0.00 0.61 0.11
62 INT255811 Binding of GNAS and MAPT 1 0.00 0.67 0.11
63 INT195121 Gene_expression of Il1r1 Positive_regulation of Positive_regulation of Gopc 1 0.17 0.26 0.11
64 INT195119 Gene_expression of Il1r1 Positive_regulation of Positive_regulation of Gfap 1 0.38 0.26 0.11
65 INT276966 Tlr2 Negative_regulation of Gene_expression of Mcpt1 1 0.09 1.38 0.1
66 INT339498 Binding of Il1rap and Positive_regulation of Irak1 1 0.01 0 0.1
67 INT175325 Binding of TLR2 and Tlr6 1 0.00 0.39 0.09
68 INT175327 Binding of TLR2 and Tlr1 1 0.00 0.39 0.09
69 INT255289 Snap25 Regulation of Gene_expression of Gnas 1 0.00 0 0.09
70 INT226515 Binding of Il1rl1 and Il33 1 0.02 0.36 0.08
71 INT284303 Mir155 Negative_regulation of Gnas 1 0.00 0.49 0.08
72 INT288210 Regulation of Tlr2 Positive_regulation of Akt1 1 0.03 0.09 0.08
73 INT288206 Tlr2 Positive_regulation of Akt1 1 0.04 0.09 0.08
74 INT276987 Tlr2 Negative_regulation of Gene_expression of Il10 1 0.15 0.19 0.08
75 INT324871 Ros1 Positive_regulation of Gene_expression of Tlr2 1 0.03 1.12 0.07
76 INT325264 Il1rap Positive_regulation of Mapk1 1 0.08 0 0.07
77 INT309941 Edn1 Positive_regulation of Tlr2 1 0.02 1.31 0.07
78 INT276980 Binding of Tlr2 and Gopc 1 0.14 0.28 0.07
79 INT294638 Bcl2a1a Positive_regulation of Tlr2 1 0.58 0.43 0.07
80 INT325262 Il1rap Positive_regulation of Mapk8 1 0.09 0 0.07
81 INT325258 Il1rap Positive_regulation of Mapk14 1 0.08 0 0.07
82 INT258290 Hmgb1 Regulation of Positive_regulation of Tlr2 1 0.46 1.04 0.05
83 INT324861 Positive_regulation of Binding of Tlr1 and Tlr6 1 0.05 0.79 0.05
84 INT324867 Positive_regulation of Binding of Tlr6 and Tlr2 1 0.10 0.79 0.05
85 INT325256 Chchd8 Regulation of Il1rl1 1 0.00 0.33 0.05
86 INT324872 Binding of Tlr1 and Tlr6 1 0.04 0.79 0.05
87 INT324864 Positive_regulation of Binding of Tlr1 and Tlr2 1 0.10 0.79 0.05
88 INT276969 Tlr2 Positive_regulation of Il10 1 0.20 0.75 0.04
89 INT276955 Tlr2 Positive_regulation of Negative_regulation of Il13 1 0.14 0.76 0.04
90 INT276978 Tlr2 Positive_regulation of Hspd1 1 0.27 0.68 0.04
91 INT276973 Tlr2 Positive_regulation of Il13 1 0.14 0.76 0.04
92 INT276981 Tlr2 Positive_regulation of Gene_expression of Il13 1 0.13 0.76 0.04
93 INT276990 Tlr2 Positive_regulation of Negative_regulation of Il10 1 0.20 0.75 0.04
94 INT279766 Binding of IGHG3 and TGM1 1 0.01 0.3 0.04
95 INT324805 Tlr2 Positive_regulation of Cd14 1 0.14 0.09 0.03
96 INT276989 Stat3 Regulation of Positive_regulation of Tlr2 1 0.22 0.13 0.03
97 INT269838 Binding of Hsp90b1 and Tlr2 1 0.26 1.75 0.03
98 INT324809 Tlr6 Positive_regulation of Cd14 1 0.12 0.09 0.03
99 INT276972 Tlr2 Negative_regulation of Gene_expression of Hand1 1 0.14 0.65 0.03
100 INT313077 Cd180 Regulation of Tlr2 1 0.01 0.09 0
101 INT297560 Binding of HSD11B1 and APOL1 1 0.04 0.88 0
102 INT275842 HPD Positive_regulation of Tlr2 1 0.01 0.76 0
103 INT249538 Binding of BDNF and GNAS 1 0.08 0 0
104 INT344224 Tlr2 Regulation of Gene_expression of Tlr4 1 0.03 0 0
105 INT284304 Binding of Adrb3 and Gnas 1 0.00 0.23 0
106 INT179302 Gene_expression of GNAS Negative_regulation of CA2 1 0.01 0 0
107 INT313076 Tlr2 Positive_regulation of Gene_expression of Il10 1 0.02 0.14 0
108 INT284302 Mir155 Regulation of Gnas 1 0.00 0.64 0
109 INT228215 Tlr2 Positive_regulation of Gene_expression of Tlr4 1 0.19 1.47 0
110 INT344220 Itgam Regulation of Transcription of Tlr2 1 0.03 0.06 0
111 INT313080 ST2 Regulation of Tlr2 1 0.02 0.09 0
112 INT316537 Binding of Tlr1 and Il23a 1 0.12 0.78 0
113 INT313079 SIGIRR Regulation of Tlr2 1 0.18 0.09 0
114 INT275840 Cfp Positive_regulation of Tlr2 1 0.02 0.75 0
115 INT231169 Gnas Positive_regulation of Gene_expression of Dmd 1 0.00 0.19 0
116 INT325271 Positive_regulation of Il33 Regulation of Gene_expression of Il1rl1 1 0.22 0 0
117 INT283201 Gm4658 Regulation of Gnas 1 0.00 0.56 0
118 INT316536 Binding of Tlr2 and Il23a 1 0.11 0.78 0
119 INT297558 Binding of APOL1 and SRA1 1 0.22 0.56 0
120 INT325836 Binding of Dnm2 and Gnas 1 0.00 0.22 0
121 INT325839 Binding of Dnm1 and Gnas 1 0.00 0.11 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for intrinsic to membrane. They are ordered first by their pain relevance and then by number of times they were reported in intrinsic to membrane. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT142594 Gene_expression of Tlr2 165 0.78 139.73 22.26
2 INT142593 Positive_regulation of Tlr2 85 0.70 75.9 13.62
3 INT62919 Regulation of Gnas 22 0.43 5.61 9.55
4 INT142596 Positive_regulation of Gene_expression of Tlr2 42 0.69 38.41 6.67
5 INT11258 Gene_expression of Gnas 58 0.58 21.6 6.33
6 INT67635 Negative_regulation of Gnas 29 0.04 11.4 6.32
7 INT142595 Negative_regulation of Tlr2 24 0.52 19.17 5.43
8 INT174688 Binding of Tlr2 45 0.42 36.65 5.25
9 INT36030 Gene_expression of Il1r1 16 0.68 11.42 4.87
10 INT98357 Binding of Gnas 11 0.41 1.87 4.35
11 INT32933 Gene_expression of GNAS 57 0.32 10.58 4.03
12 INT36029 Negative_regulation of Il1r1 9 0.41 4.64 2.3
13 INT204775 Regulation of Tlr2 21 0.41 13.6 2.18
14 INT179311 Transcription of GNAS 2 0.10 0.67 2.08
15 INT108903 Negative_regulation of GNAS 7 0.57 1.58 2.04
16 INT228195 Negative_regulation of Gene_expression of Tlr2 14 0.40 12.17 1.74
17 INT9953 Positive_regulation of Gnas 10 0.34 3.21 1.51
18 INT2620 Regulation of TGM1 1 0.01 3.27 1.5
19 INT121347 Binding of GNAS 8 0.13 3.99 1.47
20 INT28681 Gene_expression of Il1rl1 4 0.55 3.04 1.46
21 INT2619 Positive_regulation of TGM1 7 0.49 5.97 1.41
22 INT174683 Transcription of Tlr2 12 0.58 5.95 1.4
23 INT162308 Phosphorylation of GNAS 3 0.01 1.71 1.4
24 INT148562 Positive_regulation of GNAS 13 0.16 5.31 1.32
25 INT221131 Localization of Tlr2 17 0.80 13.82 1.28
26 INT70088 Binding of TGM1 9 0.41 5.3 1.22
27 INT112498 Gene_expression of TGM1 18 0.55 10.76 1.21
28 INT98489 Binding of Il1r1 3 0.36 1.46 1.06
29 INT36028 Positive_regulation of Gene_expression of Il1r1 4 0.40 1.82 0.81
30 INT215783 Localization of Gnas 1 0.12 1.64 0.76
31 INT28682 Negative_regulation of Gene_expression of Il1rl1 2 0.42 0.31 0.75
32 INT157776 Localization of TGM1 2 0.39 2.52 0.74
33 INT224630 Positive_regulation of Positive_regulation of Tlr2 6 0.46 4.14 0.73
34 INT140708 Gene_expression of Tlr1 10 0.50 5.24 0.72
35 INT228188 Regulation of Gene_expression of Tlr2 5 0.45 6.96 0.71
36 INT228470 Phosphorylation of Il1rap 1 0.11 1.34 0.7
37 INT195104 Positive_regulation of Il1r1 4 0.40 2.18 0.68
38 INT174248 Negative_regulation of Positive_regulation of Il1rap 1 0.00 0.95 0.61
39 INT174249 Positive_regulation of Il1rap 1 0.01 0.95 0.61
40 INT249551 Negative_regulation of Transcription of GNAS 1 0.06 0.16 0.6
41 INT200980 Transcription of APOL1 1 0.67 0.84 0.54
42 INT201005 Gene_expression of APOL1 9 0.75 4.66 0.53
43 INT234597 Negative_regulation of Positive_regulation of Tlr2 2 0.30 2.25 0.52
44 INT234587 Positive_regulation of Transcription of Tlr2 3 0.36 1.84 0.51
45 INT81357 Regulation of Negative_regulation of Gnas 1 0.02 0.1 0.47
46 INT288184 Binding of Tlr1 8 0.29 4.73 0.4
47 INT70086 Negative_regulation of Binding of TGM1 1 0.50 1.58 0.4
48 INT174684 Gene_expression of Tlr6 2 0.44 2.62 0.36
49 INT226389 Localization of Il1rl1 2 0.53 0.93 0.31
50 INT288189 Negative_regulation of Negative_regulation of Tlr2 1 0.26 0.43 0.28
51 INT275828 Positive_regulation of Gene_expression of Tlr1 2 0.24 1.75 0.26
52 INT288186 Regulation of Binding of Tlr2 2 0.32 1.72 0.26
53 INT224614 Regulation of Positive_regulation of Tlr2 1 0.13 0.56 0.26
54 INT200986 Positive_regulation of Gene_expression of APOL1 1 0.36 0.26 0.26
55 INT226397 Positive_regulation of Il1rl1 2 0.31 1.04 0.25
56 INT230491 Regulation of Il1r1 1 0.01 0.76 0.25
57 INT200997 Regulation of Transcription of APOL1 1 0.32 0.23 0.24
58 INT108902 Localization of GNAS 5 0.13 1.31 0.23
59 INT201019 Localization of APOL1 3 0.66 1.29 0.23
60 INT70087 Negative_regulation of TGM1 2 0.50 2.62 0.21
61 INT255967 Transcription of Tlr1 2 0.35 2.56 0.21
62 INT208539 Positive_regulation of Gene_expression of Gnas 4 0.08 2.76 0.18
63 INT325238 Negative_regulation of Il1rl1 1 0.27 0.55 0.17
64 INT324855 Binding of Tlr6 1 0.14 2.39 0.17
65 INT294633 Positive_regulation of Binding of Tlr2 1 0.44 0.42 0.16
66 INT325252 Positive_regulation of Gene_expression of Il1rl1 1 0.36 0.43 0.15
67 INT200973 Negative_regulation of APOL1 1 0.14 0.18 0.15
68 INT355270 Positive_regulation of Transcription of Tlr1 1 0.01 1.76 0.12
69 INT201000 Positive_regulation of APOL1 2 0.45 0.66 0.1
70 INT339482 Binding of Il1rap 1 0.01 0 0.1
71 INT200976 Positive_regulation of Transcription of APOL1 1 0.49 0.23 0.1
72 INT324777 Positive_regulation of Tlr6 2 0.22 0.88 0.09
73 INT127244 Binding of APOL1 1 0.33 3.29 0.09
74 INT255958 Regulation of Transcription of Tlr1 1 0.22 0.89 0.09
75 INT255976 Regulation of Transcription of Tlr2 1 0.22 0.89 0.09
76 INT107569 Transcription of Gnas 1 0.01 0 0.08
77 INT276938 Localization of Tlr1 1 0.38 0.23 0.07
78 INT276932 Localization of Tlr6 1 0.40 0.23 0.07
79 INT269821 Regulation of Localization of Tlr2 1 0.27 1.04 0.07
80 INT200974 Negative_regulation of Transcription of APOL1 1 0.27 0.23 0.06
81 INT179307 Regulation of GNAS 7 0.01 1.93 0.05
82 INT324681 Positive_regulation of Tlr1 2 0.22 2.02 0.05
83 INT277277 Regulation of Gene_expression of Gnas 2 0.00 0.33 0.04
84 INT246930 Negative_regulation of Transcription of Tlr2 1 0.36 0.92 0.04
85 INT276929 Regulation of Tlr6 1 0.24 0.74 0.04
86 INT276939 Positive_regulation of Phosphorylation of Tlr2 1 0.46 0.6 0.03
87 INT276931 Phosphorylation of Tlr2 1 0.75 0.6 0.03
88 INT226298 Positive_regulation of Gene_expression of TGM1 4 0.24 2.66 0
89 INT177312 Negative_regulation of Gene_expression of GNAS 2 0.05 0.46 0
90 INT246929 Positive_regulation of Localization of Tlr2 2 0.42 0.26 0
91 INT275829 Negative_regulation of Gene_expression of Tlr1 1 0.05 0.72 0
92 INT246927 Negative_regulation of Binding of Tlr2 1 0.31 0 0
93 INT255830 Positive_regulation of Localization of GNAS 1 0.01 0.28 0
94 INT325243 Regulation of Gene_expression of Il1rl1 1 0.44 0 0
95 INT289448 Transcription of TGM1 1 0.19 0.1 0
96 INT297583 Regulation of APOL1 1 0.40 0.57 0
97 INT202870 Negative_regulation of Negative_regulation of Gnas 1 0.01 0.53 0
98 INT179318 Regulation of Transcription of GNAS 1 0.01 0 0
99 INT202861 Positive_regulation of Negative_regulation of Gnas 1 0.01 0.39 0
100 INT179310 Positive_regulation of Gene_expression of GNAS 1 0.01 0 0
101 INT351494 Positive_regulation of Protein_catabolism of GNAS 1 0.00 0.94 0
102 INT325235 Transcription of Il1rl1 1 0.49 0.15 0
103 INT351518 Protein_catabolism of GNAS 1 0.01 1.29 0
104 INT325245 Positive_regulation of Localization of Il1rl1 1 0.31 0 0
105 INT255817 Positive_regulation of Positive_regulation of GNAS 1 0.01 0.85 0
106 INT249548 Negative_regulation of Positive_regulation of GNAS 1 0.06 0 0
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