GO:0031258

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Name lamellipodium membrane
Categary Component
Go Slim No
Go Link GO:0031258
Unique Molecular Interactions 93
Total Molecular Interactions 116
Total Single Events 847
Pain Genes Associated 11

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for lamellipodium membrane. They are ordered first by their pain relevance and then by number of times they were reported for lamellipodium membrane. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT201950 IFNA1 Positive_regulation of Binding of DPP4 1 0.12 2.17 1.47
2 INT201946 IFNA1 Positive_regulation of DPP4 1 0.17 2.16 1.46
3 INT131949 ANTXR1 Positive_regulation of NAV1 1 0.03 0.23 1.38
4 INT201942 DPP4 Negative_regulation of CXCL10 1 0.33 0.9 1.3
5 INT52955 Binding of Slc6a3 and Pdpn 1 0.17 1.11 1.22
6 INT73311 Binding of Oprm1 and Pdpn 1 0.08 0.71 1.06
7 INT84466 DPP4 Regulation of Localization of Naga 1 0.00 0.87 0.78
8 INT88921 Positive_regulation of CYP2D6 Negative_regulation of ANTXR1 1 0.00 0.8 0.75
9 INT88922 CYP2D6 Negative_regulation of ANTXR1 1 0.00 0.8 0.75
10 INT201947 IFNA1 Positive_regulation of Gene_expression of DPP4 1 0.11 1.09 0.74
11 INT129271 Binding of ANTXR1 and Efs 1 0.00 0 0.56
12 INT265463 CSPG4 Negative_regulation of Gene_expression of IL6 1 0.06 1.6 0.56
13 INT201943 Regulation of Binding of DPP4 and CXCL10 1 0.20 0.58 0.42
14 INT52954 Binding of Pdpn and Flvcr2 1 0.05 0.42 0.41
15 INT265465 CSPG4 Negative_regulation of Gene_expression of IL8 1 0.07 0.98 0.39
16 INT201948 Binding of DPP4 and CXCL10 1 0.27 0.54 0.39
17 INT305407 Binding of ST8SIA2 and ANTXR1 1 0.00 0.09 0.38
18 INT188427 IL6 Positive_regulation of Pdxp 1 0.00 0.84 0.38
19 INT305405 Binding of KCNMA1 and ANTXR1 1 0.00 0.09 0.38
20 INT311228 DPP4 Negative_regulation of Localization of GLP1R 1 0.31 1.25 0.32
21 INT64892 ANTXR1 Regulation of Gtpbp4 1 0.00 0.47 0.28
22 INT321980 Negative_regulation of Dpp4 Negative_regulation of Positive_regulation of Ins1 1 0.16 0.81 0.22
23 INT312708 DPP8 Positive_regulation of DPP4 1 0.24 0.54 0.19
24 INT312706 DPP9 Positive_regulation of DPP4 1 0.26 0.54 0.19
25 INT311226 DPP4 Negative_regulation of GLP1R 1 0.31 0.65 0.16
26 INT312707 Positive_regulation of DPP4 Positive_regulation of Gene_expression of CD86 1 0.20 0.45 0.13
27 INT344314 PDPN Positive_regulation of Phosphorylation of MAPK8 1 0.35 0.67 0.13
28 INT93745 Binding of Dpp4 and Hephl1 1 0.02 0.15 0.11
29 INT242204 DPP4 Positive_regulation of Gene_expression of GLP1R 1 0.03 0.66 0.1
30 INT269592 MAPKAP1 Positive_regulation of Phosphorylation of CFL1 1 0.03 0 0.09
31 INT194718 DPP4 Positive_regulation of MAPK1 1 0.02 0.29 0.09
32 INT265466 CSPG4 Regulation of Phosphorylation of TP53 1 0.09 0.15 0.09
33 INT321465 Gip Regulation of DPP4 1 0.03 0.59 0.06
34 INT224922 Binding of FAP and TARM1 1 0.06 1.4 0.06
35 INT321466 Glp1r Regulation of DPP4 1 0.04 0.59 0.06
36 INT321467 Binding of DPP4 and Glp1r 1 0.03 0.42 0.05
37 INT265456 CSPG4 Regulation of ROS1 1 0.05 0.24 0.04
38 INT265451 CSPG4 Positive_regulation of RNGTT 1 0.03 0.24 0.04
39 INT265453 CSPG4 Regulation of Phosphorylation of ROS1 1 0.05 0.24 0.04
40 INT265457 CSPG4 Negative_regulation of IL6 1 0.06 0.24 0.04
41 INT265462 CSPG4 Negative_regulation of Positive_regulation of CASP9 1 0.07 1.2 0.04
42 INT344312 PDPN Positive_regulation of ITK 1 0.05 0.26 0.04
43 INT265461 CSPG4 Negative_regulation of Gene_expression of CASP9 1 0.06 1.2 0.04
44 INT269584 Binding of CFL1 and ROCK1 1 0.03 0.05 0.03
45 INT312943 ANTXR1 Regulation of Gene_expression of Hes3 1 0.00 0.67 0.03
46 INT265464 CSPG4 Regulation of Gene_expression of TP53 1 0.09 0.23 0.03
47 INT344317 PDPN Negative_regulation of VEGFA 1 0.08 0.67 0.03
48 INT312942 ANTXR1 Regulation of Localization of Hes3 1 0.00 0.67 0.03
49 INT344308 Positive_regulation of PDPN Negative_regulation of VEGFA 1 0.09 0.24 0.03
50 INT66344 ANTXR1 Positive_regulation of ART1 1 0.00 0.69 0
51 INT198186 Binding of ANTXR2 and Antxr1 1 0.02 0.49 0
52 INT311229 DPP4 Positive_regulation of Gene_expression of INS 1 0.32 0.57 0
53 INT321981 Dpp4 Regulation of Glp1r 1 0.07 1.06 0
54 INT235645 TP53 Regulation of EPHA2 1 0.10 0.97 0
55 INT265468 CSPG4 Positive_regulation of Gene_expression of ROS1 1 0.08 0.4 0
56 INT344315 MAPK8 Positive_regulation of Negative_regulation of PDPN 1 0.35 0.56 0
57 INT235648 Binding of EFNA1 and EPHA2 1 0.23 1.3 0
58 INT255024 DPP4 Negative_regulation of Protein_catabolism of GLP1R 1 0.14 0.78 0
59 INT235647 TP63 Regulation of EPHA2 1 0.15 0.97 0
60 INT40517 Binding of NA and Antxr1 1 0.06 0 0
61 INT344313 PDPN Positive_regulation of VEGFA 1 0.09 0.8 0
62 INT312944 ANTXR1 Positive_regulation of Localization of Hes3 1 0.01 0.36 0
63 INT235651 TP73 Regulation of EPHA2 1 0.15 0.98 0
64 INT344319 MAPK8 Positive_regulation of PDPN 1 0.35 0.5 0
65 INT269594 GOPC Positive_regulation of Phosphorylation of CFL1 1 0.04 0 0
66 INT321982 Dpp4 Regulation of Gene_expression of Glp1r 1 0.07 1.06 0
67 INT265460 CSPG4 Negative_regulation of Positive_regulation of CASP3 1 0.06 0.27 0
68 INT321976 Dpp4 Regulation of Gcg 1 0.13 1.06 0
69 INT271644 VCAN Regulation of Gene_expression of CSPG4 1 0.38 0.15 0
70 INT255041 DPP4 Positive_regulation of GIP 1 0.49 0.32 0
71 INT255021 DPP4 Negative_regulation of Protein_catabolism of GIP 1 0.32 0.78 0
72 INT198184 Binding of PLDN and Antxr1 1 0.00 1.03 0
73 INT312945 ANTXR1 Regulation of Setd1a 1 0.00 0.36 0
74 INT271645 VCAN Regulation of CSPG4 1 0.38 0.15 0
75 INT255043 DPP4 Positive_regulation of GLP1R 1 0.35 0.32 0
76 INT344307 PDPN Negative_regulation of Gene_expression of VEGFA 1 0.08 0.36 0
77 INT269560 TMPO Regulation of Phosphorylation of CFL1 1 0.07 0 0
78 INT344318 PDPN Positive_regulation of Positive_regulation of RHOA 1 0.11 0.92 0
79 INT269595 TMPO Positive_regulation of Phosphorylation of CFL1 1 0.07 0 0
80 INT255023 Negative_regulation of DPP4 Positive_regulation of GIP 1 0.35 0.27 0
81 INT271642 GFAP Regulation of CSPG4 1 0.18 0.15 0
82 INT265455 CSPG4 Negative_regulation of Positive_regulation of CASP8 1 0.04 0.27 0
83 INT198185 Positive_regulation of Binding of ANTXR2 and Antxr1 1 0.02 0.39 0
84 INT271643 GFAP Regulation of Gene_expression of CSPG4 1 0.18 0.15 0
85 INT344316 VEGFA Positive_regulation of PDPN 1 0.09 0.4 0
86 INT321977 Dpp4 Regulation of Negative_regulation of Gcg 1 0.13 1.06 0
87 INT348644 Binding of DPP4 and GLP1R 1 0.16 0.5 0
88 INT344311 PDPN Positive_regulation of Negative_regulation of VEGFA 1 0.09 0.81 0
89 INT255042 Negative_regulation of DPP4 Positive_regulation of GLP1R 1 0.33 0.34 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for lamellipodium membrane. They are ordered first by their pain relevance and then by number of times they were reported in lamellipodium membrane. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT84464 Gene_expression of DPP4 101 0.78 56.15 17.53
2 INT132036 Negative_regulation of DPP4 126 0.59 63.24 9.51
3 INT81378 Negative_regulation of Dpp4 18 0.59 7.87 7.42
4 INT142065 Phosphorylation of CFL1 8 0.78 0.87 6.3
5 INT52952 Binding of Pdpn 8 0.13 3.57 4.79
6 INT20925 Binding of ANTXR1 15 0.01 4.2 3.8
7 INT142066 Positive_regulation of Phosphorylation of CFL1 5 0.48 0.24 3.73
8 INT13451 Positive_regulation of DPP4 23 0.68 9.33 3.62
9 INT201959 Positive_regulation of Gene_expression of DPP4 13 0.53 6.24 3.4
10 INT201952 Binding of DPP4 11 0.37 8.81 2.91
11 INT12619 Positive_regulation of ANTXR1 7 0.49 3.17 2.61
12 INT81377 Gene_expression of Dpp4 8 0.71 5.15 2.51
13 INT61805 Positive_regulation of Dpp4 4 0.44 0.41 2.49
14 INT84465 Localization of DPP4 8 0.75 7.28 2.29
15 INT142064 Negative_regulation of Phosphorylation of CFL1 3 0.56 0.42 2.06
16 INT15090 Regulation of ANTXR1 4 0.31 2.4 2.05
17 INT47062 Gene_expression of ANTXR1 10 0.66 4.63 1.93
18 INT23176 Gene_expression of Pdpn 6 0.75 4.06 1.65
19 INT93744 Binding of Dpp4 4 0.48 0.91 1.61
20 INT116836 Binding of FAP 6 0.37 6.76 1.47
21 INT84463 Regulation of Gene_expression of DPP4 5 0.39 4.81 1.33
22 INT1787 Binding of Antxr1 13 0.32 2.62 1.22
23 INT201955 Regulation of DPP4 18 0.45 11.91 1.18
24 INT265491 Gene_expression of CSPG4 16 0.58 7.27 1.07
25 INT4099 Regulation of Antxr1 2 0.17 0.09 0.97
26 INT226478 Protein_catabolism of DPP4 11 0.85 5.52 0.95
27 INT84462 Positive_regulation of Localization of DPP4 2 0.32 1.27 0.85
28 INT41534 Negative_regulation of ANTXR1 4 0.42 1.17 0.83
29 INT47937 Positive_regulation of Gene_expression of ANTXR1 3 0.49 0.86 0.8
30 INT41536 Localization of ANTXR1 7 0.60 2.24 0.79
31 INT67252 Regulation of Pdpn 1 0.00 0.9 0.74
32 INT25960 Regulation of Dpp4 6 0.32 1.69 0.73
33 INT110349 Regulation of Binding of Dpp4 1 0.26 0 0.72
34 INT113893 Protein_catabolism of Dpp4 3 0.57 0.69 0.7
35 INT142063 Negative_regulation of CFL1 1 0.56 0 0.69
36 INT52951 Negative_regulation of Binding of Pdpn 1 0.16 0.63 0.66
37 INT73522 Negative_regulation of Binding of ANTXR1 1 0.00 0.18 0.64
38 INT309300 Positive_regulation of Regulation of ANTXR1 1 0.02 0 0.53
39 INT4098 Negative_regulation of Antxr1 2 0.17 0.61 0.52
40 INT61804 Negative_regulation of Positive_regulation of Dpp4 1 0.37 0.24 0.42
41 INT235660 Gene_expression of EPHA2 27 0.75 23.46 0.4
42 INT235655 Positive_regulation of Gene_expression of EPHA2 14 0.67 13.48 0.35
43 INT56695 Positive_regulation of Gene_expression of Antxr1 1 0.25 0 0.35
44 INT56696 Gene_expression of Antxr1 13 0.34 3.04 0.34
45 INT265490 Localization of CSPG4 3 0.20 1.5 0.33
46 INT110306 Positive_regulation of Gene_expression of Dpp4 1 0.06 0.77 0.33
47 INT235658 Positive_regulation of EPHA2 4 0.67 3.42 0.32
48 INT188420 Positive_regulation of Pdxp 1 0.04 0.8 0.32
49 INT265480 Negative_regulation of CSPG4 5 0.32 2.37 0.31
50 INT6700 Phosphorylation of ANTXR1 2 0.03 0.42 0.31
51 INT85426 Transcription of CSPG4 1 0.23 1.03 0.3
52 INT226476 Positive_regulation of Protein_catabolism of DPP4 2 0.45 1.64 0.28
53 INT318437 Negative_regulation of Pdpn 1 0.47 0.87 0.25
54 INT41535 Negative_regulation of Negative_regulation of ANTXR1 1 0.01 0.08 0.23
55 INT58879 Negative_regulation of Localization of ANTXR1 2 0.35 0.55 0.22
56 INT201956 Regulation of Binding of DPP4 1 0.34 0.35 0.21
57 INT88924 Negative_regulation of FAP 2 0.41 1.77 0.2
58 INT352913 Regulation of EPHA2 1 0.05 0.74 0.2
59 INT348918 Negative_regulation of Negative_regulation of CSPG4 1 0.06 0.59 0.2
60 INT312711 Phosphorylation of DPP4 1 0.59 0.42 0.19
61 INT312714 Positive_regulation of Phosphorylation of DPP4 1 0.44 0.42 0.19
62 INT152681 Gene_expression of PDPN 29 0.65 23.06 0.18
63 INT97473 Positive_regulation of FAP 4 0.34 2.72 0.18
64 INT269670 Gene_expression of CFL1 5 0.58 0.74 0.16
65 INT160121 Localization of PDPN 1 0.73 1.07 0.16
66 INT311240 Negative_regulation of Gene_expression of DPP4 6 0.59 3.43 0.13
67 INT255072 Regulation of Negative_regulation of DPP4 2 0.44 1.22 0.13
68 INT116835 Regulation of FAP 1 0.03 0 0.1
69 INT230968 Positive_regulation of CSPG4 4 0.35 1.28 0.09
70 INT311232 Negative_regulation of Protein_catabolism of DPP4 2 0.33 1.18 0.09
71 INT326309 Positive_regulation of Binding of ANTXR1 1 0.01 0.65 0.05
72 INT312377 Transcription of DPP4 1 0.72 3.38 0.05
73 INT344332 Positive_regulation of Gene_expression of PDPN 1 0.58 0.72 0.04
74 INT255032 Negative_regulation of Localization of DPP4 1 0.30 0.24 0.04
75 INT344330 Phosphorylation of PDPN 1 0.53 0.15 0.04
76 INT255034 Positive_regulation of Negative_regulation of DPP4 2 0.37 0.83 0.03
77 INT271684 Binding of CSPG4 1 0.28 0.46 0.03
78 INT265493 Positive_regulation of Localization of CSPG4 1 0.13 0.66 0.03
79 INT271682 Positive_regulation of Binding of CSPG4 1 0.38 0.47 0.03
80 INT271683 Regulation of Gene_expression of CSPG4 1 0.34 0.48 0.03
81 INT336399 Transcription of EPHA2 1 0.24 2.21 0.03
82 INT235654 Binding of EPHA2 5 0.36 4.26 0
83 INT265476 Positive_regulation of Gene_expression of CSPG4 3 0.38 1.25 0
84 INT268374 Gene_expression of FAP 2 0.37 6.6 0
85 INT344342 Binding of PDPN 1 0.31 0.74 0
86 INT269614 Regulation of Phosphorylation of CFL1 1 0.14 0.24 0
87 INT193336 Negative_regulation of Positive_regulation of FAP 1 0.29 1.23 0
88 INT198147 Localization of Antxr1 1 0.12 0.34 0
89 INT265478 Positive_regulation of Positive_regulation of CSPG4 1 0.13 0.39 0
90 INT344340 Negative_regulation of Gene_expression of PDPN 1 0.36 1.53 0
91 INT271688 Negative_regulation of Gene_expression of CSPG4 1 0.32 1.03 0
92 INT344339 Positive_regulation of PDPN 1 0.39 0.98 0
93 INT268370 Phosphorylation of FAP 1 0.24 1.11 0
94 INT131634 Negative_regulation of Gene_expression of Dpp4 1 0.04 0.07 0
95 INT266427 Localization of CFL1 1 0.74 0.25 0
96 INT269623 Positive_regulation of Gene_expression of CFL1 1 0.16 0 0
97 INT344335 Regulation of PDPN 1 0.38 0.41 0
98 INT344343 Transcription of PDPN 1 0.60 0.54 0
99 INT344337 Regulation of Negative_regulation of PDPN 1 0.23 0.05 0
100 INT344334 Negative_regulation of PDPN 1 0.36 2.76 0
101 INT271687 Regulation of CSPG4 1 0.34 1.96 0
102 INT344333 Negative_regulation of Binding of PDPN 1 0.36 0.74 0
103 INT266426 Positive_regulation of CFL1 1 0.60 1.82 0
104 INT235652 Localization of EPHA2 1 0.72 0.89 0
105 INT202389 Phosphorylation of Pdpn 1 0.61 0 0
106 INT300618 Negative_regulation of Gene_expression of FAP 1 0.21 2.05 0
107 INT339942 Negative_regulation of Negative_regulation of DPP4 1 0.33 0.27 0
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