GO:0031284

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Name positive regulation of guanylate cyclase activity
Categary Process
Go Slim No
Go Link GO:0031284
Unique Molecular Interactions 133
Total Molecular Interactions 178
Total Single Events 1915
Pain Genes Associated 5

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for positive regulation of guanylate cyclase activity. They are ordered first by their pain relevance and then by number of times they were reported for positive regulation of guanylate cyclase activity. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT278223 Binding of NOS3 and ACSM3 1 0.41 6.32 1.65
2 INT134764 Ghrl Regulation of Gene_expression of NOS3 1 0.02 2.66 1.4
3 INT216736 Binding of ADORA2B and ATP6V0A1 2 0.08 0.06 0.93
4 INT220031 Casp3 Positive_regulation of Gene_expression of Nos3 1 0.04 0 0.92
5 INT194856 Positive_regulation of Adora2b Negative_regulation of Positive_regulation of Mmp13 1 0.01 0.73 0.85
6 INT102931 Nos3 Positive_regulation of Nos2 1 0.43 1.63 0.83
7 INT322266 Binding of LIG4 and NOS3 1 0.02 2.35 0.82
8 INT102932 Nos3 Positive_regulation of NOS1 1 0.03 1.63 0.82
9 INT252455 Binding of Adora2b and SLURP1 1 0.02 0.6 0.81
10 INT213026 Hdl1 Positive_regulation of Nos3 5 0.16 7.92 0.73
11 INT220032 Nos1 Positive_regulation of Nos3 1 0.32 0.45 0.66
12 INT308668 Akt1 Positive_regulation of Nos3 3 0.05 4.61 0.65
13 INT175700 Nos3 Negative_regulation of smc 1 0.01 1.05 0.59
14 INT278228 Binding of MBNL1 and NOS3 1 0.05 2.06 0.54
15 INT308656 Pik3r1 Positive_regulation of Nos3 1 0.02 1.8 0.5
16 INT233503 Tlr4 Positive_regulation of Adora2b 1 0.06 0.45 0.47
17 INT103025 Calca Positive_regulation of Nos3 1 0.25 0.41 0.46
18 INT103027 Ptgis Positive_regulation of Nos3 1 0.06 0.42 0.46
19 INT95276 Obfc2a Negative_regulation of Nos3 1 0.02 1.02 0.46
20 INT103030 Calca Positive_regulation of Positive_regulation of Nos3 1 0.26 0.41 0.46
21 INT216737 Binding of ADORA2B and TCFL5 1 0.03 0.05 0.39
22 INT278226 Binding of FOSB and NOS3 1 0.03 1.22 0.36
23 INT254123 Binding of Adora2b and Rai1 1 0.24 0.75 0.35
24 INT252453 Binding of AR and Adora2b 1 0.05 0 0.35
25 INT333158 asa Positive_regulation of Nos3 1 0.11 0.18 0.32
26 INT333166 Tlx2 Positive_regulation of Gene_expression of Nos3 1 0.08 0.18 0.32
27 INT333155 Tlx2 Regulation of Gene_expression of Nos3 1 0.08 0.18 0.32
28 INT333152 Tlx2 Positive_regulation of Nos3 1 0.08 0.18 0.32
29 INT333169 asa Positive_regulation of Gene_expression of Nos3 1 0.11 0.18 0.32
30 INT333164 asa Regulation of Nos3 1 0.11 0.18 0.32
31 INT333149 asa Regulation of Gene_expression of Nos3 1 0.11 0.18 0.32
32 INT333167 Tlx2 Regulation of Nos3 1 0.08 0.18 0.32
33 INT241739 Sdhb Regulation of Adora2b 1 0.04 0.63 0.31
34 INT122575 Akt1 Positive_regulation of Phosphorylation of Nos3 4 0.37 3.89 0.29
35 INT141871 Binding of Nos3 and Slc2a4 1 0.25 0.51 0.28
36 INT252456 IGKV2D-29 Regulation of Gene_expression of Adora2b 1 0.07 0 0.24
37 INT224135 Binding of ARRB2 and Adora2b 1 0.14 0.07 0.23
38 INT281901 Binding of KNG1 and NOS3 1 0.05 0.17 0.22
39 INT122576 Pik3cd Positive_regulation of Phosphorylation of Nos3 1 0.28 0.45 0.21
40 INT224133 Negative_regulation of Adora2b Positive_regulation of ADCY1 1 0.01 0.1 0.2
41 INT239227 Prkca Regulation of Nos3 1 0.02 0.97 0.2
42 INT224134 Adora2b Positive_regulation of ADCY1 1 0.01 0.1 0.2
43 INT226542 Negative_regulation of Adora2b Positive_regulation of IL19 1 0.08 0.58 0.2
44 INT226525 Adora2b Positive_regulation of IL19 1 0.03 0.58 0.2
45 INT175908 Binding of NOS3 and ROS1 1 0.10 1.84 0.19
46 INT137417 MAPK7 Regulation of Gene_expression of NOS3 1 0.00 0.5 0.19
47 INT269333 Binding of BDKRB2 and NOS3 1 0.02 0 0.17
48 INT252454 Negative_regulation of Binding of Adora2b and SLURP1 1 0.02 0.33 0.16
49 INT224136 ARRB2 Positive_regulation of Adora2b 1 0.19 0 0.16
50 INT224132 ARRB2 Negative_regulation of Positive_regulation of Adora2b 1 0.14 0.28 0.15
51 INT269332 Binding of NOS3 and TMPO 1 0.01 0 0.12
52 INT321965 Rock1 Positive_regulation of Nos3 1 0.28 1.99 0.12
53 INT213042 Apoa1 Positive_regulation of Nos3 1 0.10 2.17 0.11
54 INT288616 EPO Positive_regulation of Nos3 1 0.08 0.69 0.11
55 INT281905 Binding of AGTR2 and NOS3 1 0.08 0.37 0.1
56 INT302511 Binding of OPA1 and Nos3 1 0.02 1.57 0.1
57 INT172816 Crp Positive_regulation of Transcription of Nos3 1 0.06 0.91 0.1
58 INT172817 Crp Positive_regulation of Regulation of Nos3 1 0.09 0.84 0.1
59 INT184814 NOS3 Positive_regulation of Gene_expression of NOS1 1 0.09 0.54 0.1
60 INT281899 Binding of ANG and NOS3 1 0.12 0.37 0.1
61 INT252790 Binding of NOS1 and NOS3 1 0.03 0.37 0.1
62 INT249848 Fgf2 Positive_regulation of Gene_expression of Nos3 1 0.33 0.44 0.1
63 INT172819 Crp Positive_regulation of Gene_expression of Nos3 1 0.06 0.91 0.1
64 INT249851 VEGFA Positive_regulation of Gene_expression of Nos3 1 0.05 0.44 0.1
65 INT172821 Crp Positive_regulation of Negative_regulation of Nos3 1 0.06 0.84 0.1
66 INT213023 Hdl1 Regulation of Nos3 2 0.09 4.06 0.09
67 INT192249 Angpt1 Positive_regulation of Localization of NOS3 1 0.01 0.46 0.09
68 INT252803 Binding of NOS3 and ISYNA1 1 0.02 0.32 0.09
69 INT192248 Angpt1 Positive_regulation of NOS3 1 0.01 0.46 0.09
70 INT192250 Positive_regulation of Angpt1 Positive_regulation of NOS3 1 0.01 0.46 0.09
71 INT241741 Sdhb Positive_regulation of Transcription of Adora2b 1 0.07 0.28 0.08
72 INT309390 Gene_expression of Sod2 Negative_regulation of Nos3 1 0.31 0.2 0.08
73 INT181645 Edn1 Positive_regulation of NOS3 1 0.02 0.21 0.07
74 INT250015 Binding of FLNA and Nos3 1 0.05 1.09 0.06
75 INT246691 Ide Positive_regulation of Gene_expression of Nos3 1 0.03 0.26 0.05
76 INT249954 Cpa1 Positive_regulation of Nos3 1 0.04 0.36 0.05
77 INT213047 Hdl1 Positive_regulation of Gene_expression of Nos3 1 0.14 0.94 0.04
78 INT213031 Positive_regulation of Pik3r1 Positive_regulation of Gene_expression of Nos3 1 0.10 0.8 0.04
79 INT231438 LEP Positive_regulation of Negative_regulation of NOS3 1 0.09 0.32 0.03
80 INT181618 NOS3 Positive_regulation of INS 1 0.02 0.59 0.03
81 INT281908 VEGFA Positive_regulation of NOS3 1 0.14 0.14 0
82 INT249953 Cpa1 Regulation of Nos3 1 0.03 0.08 0
83 INT183248 LPA Positive_regulation of NOS3 1 0.02 0 0
84 INT98710 Pdyn Negative_regulation of Nos3 1 0.02 0 0
85 INT249935 Nos3 Regulation of Nos2 1 0.25 0.19 0
86 INT133825 TNF Negative_regulation of NOS3 1 0.28 0.06 0
87 INT305265 Obsty1 Negative_regulation of Phosphorylation of Nos3 1 0.05 0.78 0
88 INT249937 Nos1 Regulation of Nos3 1 0.23 0.19 0
89 INT268013 Binding of Nos3 and Acot1 1 0.02 1.48 0
90 INT340178 Car2 Positive_regulation of Positive_regulation of Nos3 1 0.01 0.26 0
91 INT305254 Obsty1 Regulation of Gene_expression of Nos3 1 0.03 0.97 0
92 INT98711 Regulation of Pdyn Negative_regulation of Nos3 1 0.02 0 0
93 INT351165 Binding of CAV1 and Nos3 1 0.09 1.46 0
94 INT260134 CGA Positive_regulation of Gene_expression of Nos3 1 0.16 0.13 0
95 INT334102 Nos3 Positive_regulation of Gene_expression of ISYNA1 1 0.01 0.59 0
96 INT133824 IL1B Negative_regulation of NOS3 1 0.48 0.06 0
97 INT323279 Binding of Nos3 and Arg2 1 0.01 0.67 0
98 INT333560 NOS3 Regulation of HCK 1 0.01 0.2 0
99 INT204321 NOS3 Regulation of SIRT1 1 0.23 0.1 0
100 INT227796 Binding of Acsl1 and Nos3 1 0.16 1.16 0
101 INT343716 Nos3 Positive_regulation of Pde6b 1 0.20 0 0
102 INT260564 Binding of Nos3 and T2dm2 1 0.05 3.96 0
103 INT305262 Obsty1 Positive_regulation of Phosphorylation of Nos3 1 0.05 0.96 0
104 INT327809 Binding of ADORA2B and IL8 1 0.03 0.3 0
105 INT260563 Hdl1 Positive_regulation of Positive_regulation of Nos3 1 0.05 1.55 0
106 INT343718 Nos3 Regulation of Pde6b 1 0.10 0 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for positive regulation of guanylate cyclase activity. They are ordered first by their pain relevance and then by number of times they were reported in positive regulation of guanylate cyclase activity. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT83199 Gene_expression of Nos3 193 0.78 100.72 51.57
2 INT65245 Gene_expression of Nos3 121 0.78 98.14 41.56
3 INT83198 Positive_regulation of Nos3 78 0.64 35.69 17.71
4 INT125947 Gene_expression of Adora2b 57 0.75 23.69 17
5 INT216751 Gene_expression of ADORA2B 36 0.60 3.42 15.6
6 INT194850 Positive_regulation of Adora2b 43 0.61 20.57 13.89
7 INT83200 Positive_regulation of Gene_expression of Nos3 48 0.70 24.75 12.99
8 INT121242 Positive_regulation of Gene_expression of Nos3 37 0.69 31.96 12.71
9 INT83201 Gene_expression of NOS3 93 0.78 47.16 12.48
10 INT73431 Positive_regulation of Nos3 82 0.65 53.22 11.61
11 INT95271 Negative_regulation of Nos3 46 0.53 24.1 9.71
12 INT76091 Positive_regulation of NOS3 48 0.61 18.4 7.92
13 INT172789 Regulation of Gene_expression of Nos3 15 0.53 16.23 7.86
14 INT65246 Negative_regulation of Nos3 36 0.50 25.65 7.62
15 INT216752 Binding of ADORA2B 17 0.36 0.76 7.36
16 INT83712 Transcription of Nos3 19 0.69 13.09 6.31
17 INT216840 Binding of Adora2b 3 0.47 5.23 4.85
18 INT83991 Regulation of Nos3 25 0.44 9.89 4.06
19 INT102515 Binding of Nos3 19 0.45 9.41 4.01
20 INT224046 Negative_regulation of Adora2b 9 0.43 4 3.6
21 INT70958 Binding of NOS3 19 0.37 11.84 3.29
22 INT92814 Negative_regulation of NOS3 25 0.51 20.67 3.07
23 INT91869 Transcription of NOS3 13 0.67 6.81 2.86
24 INT101883 Regulation of Gene_expression of Nos3 11 0.52 6.71 2.73
25 INT90675 Negative_regulation of Gene_expression of Nos3 15 0.46 11.11 2.7
26 INT145101 Transcription of Nos3 8 0.70 6.04 2.47
27 INT73809 Regulation of Nos3 18 0.45 10.05 2.27
28 INT141299 Negative_regulation of Gene_expression of Nos3 9 0.55 5.38 2.17
29 INT224047 Regulation of Adora2b 7 0.27 3.23 2.12
30 INT82166 Regulation of NOS3 14 0.54 7.57 2.08
31 INT91594 Localization of NOS3 12 0.78 5.39 2.02
32 INT216839 Positive_regulation of Positive_regulation of Adora2b 5 0.45 2.27 2
33 INT76532 Binding of Nos3 13 0.37 9.32 1.87
34 INT60999 Localization of Nos3 12 0.74 5.28 1.75
35 INT107923 Regulation of Gene_expression of NOS3 11 0.61 2.73 1.73
36 INT216749 Positive_regulation of ADORA2B 6 0.37 0.89 1.72
37 INT224049 Transcription of Adora2b 6 0.69 5.12 1.67
38 INT216847 Transcription of ADORA2B 1 0.51 0.93 1.55
39 INT181639 Positive_regulation of Positive_regulation of NOS3 8 0.41 3.72 1.41
40 INT83713 Positive_regulation of Transcription of Nos3 3 0.67 2.92 1.38
41 INT89785 Regulation of Transcription of Nos3 1 0.32 0.85 1.36
42 INT91863 Negative_regulation of Gene_expression of NOS3 13 0.51 9.43 1.34
43 INT136612 Positive_regulation of Positive_regulation of Nos3 5 0.43 4.22 1.26
44 INT212983 Positive_regulation of Positive_regulation of Nos3 9 0.51 7.08 1.23
45 INT241724 Localization of Adora2b 2 0.75 1.21 1.14
46 INT159477 Phosphorylation of NOS3 14 0.72 1.54 1.08
47 INT224042 Phosphorylation of Adora2b 1 0.29 0.25 1.08
48 INT107922 Positive_regulation of Gene_expression of NOS3 17 0.60 9.32 1.04
49 INT217050 Positive_regulation of Gene_expression of Adora2b 3 0.50 1.19 0.92
50 INT122572 Phosphorylation of Nos3 37 0.65 25.23 0.75
51 INT194851 Protein_catabolism of Adora2b 1 0.17 0.6 0.75
52 INT241715 Negative_regulation of Gene_expression of Adora2b 2 0.43 0.48 0.73
53 INT152562 Regulation of Transcription of NOS3 1 0.23 0.34 0.71
54 INT193486 Negative_regulation of Negative_regulation of Nos3 3 0.34 2.21 0.68
55 INT252430 Negative_regulation of Binding of Adora2b 1 0.26 0.27 0.65
56 INT216750 Positive_regulation of Gene_expression of ADORA2B 1 0.34 0 0.64
57 INT216761 Positive_regulation of Binding of ADORA2B 1 0.34 0 0.63
58 INT181576 Phosphorylation of Nos3 7 0.59 1.35 0.6
59 INT224056 Regulation of Gene_expression of Adora2b 2 0.27 0.12 0.59
60 INT159476 Positive_regulation of Phosphorylation of NOS3 6 0.44 1.43 0.58
61 INT141864 Negative_regulation of Binding of Nos3 3 0.39 2.27 0.56
62 INT216757 Protein_catabolism of ADORA2B 1 0.67 0 0.5
63 INT91864 Negative_regulation of Transcription of NOS3 4 0.54 1.41 0.48
64 INT216753 Regulation of Binding of ADORA2B 1 0.18 0 0.48
65 INT145100 Regulation of Transcription of Nos3 4 0.44 2.05 0.46
66 INT144095 Localization of Nos3 8 0.57 4.5 0.43
67 INT216855 Negative_regulation of ADORA2B 1 0.32 0.05 0.43
68 INT159479 Positive_regulation of Binding of NOS3 2 0.50 0.63 0.41
69 INT193491 Negative_regulation of Positive_regulation of Nos3 2 0.36 1.67 0.4
70 INT95273 Regulation of Negative_regulation of Nos3 2 0.20 0.85 0.37
71 INT252432 Positive_regulation of Localization of Adora2b 1 0.30 0.06 0.37
72 INT252431 Negative_regulation of Positive_regulation of Adora2b 1 0.26 0.76 0.35
73 INT212933 Regulation of Binding of Nos3 2 0.34 0.88 0.24
74 INT172796 Regulation of Negative_regulation of Nos3 1 0.16 1.4 0.23
75 INT316565 Negative_regulation of Regulation of Nos3 1 0.32 1.01 0.22
76 INT73810 Negative_regulation of Regulation of Nos3 2 0.36 1.01 0.21
77 INT118276 Regulation of Positive_regulation of Nos3 1 0.09 0 0.21
78 INT269409 Regulation of Phosphorylation of NOS3 1 0.18 0 0.2
79 INT163997 Positive_regulation of Negative_regulation of Nos3 1 0.49 1.15 0.2
80 INT92815 Positive_regulation of Negative_regulation of NOS3 1 0.12 1.03 0.2
81 INT141866 Regulation of Localization of Nos3 1 0.42 0.24 0.18
82 INT257201 Positive_regulation of Negative_regulation of Nos3 1 0.12 0 0.18
83 INT224051 Regulation of Phosphorylation of Adora2b 1 0.09 0.09 0.18
84 INT269403 Regulation of Positive_regulation of NOS3 1 0.18 0 0.17
85 INT224055 Negative_regulation of Phosphorylation of Adora2b 1 0.15 0 0.16
86 INT224054 Positive_regulation of Phosphorylation of Adora2b 1 0.17 0 0.16
87 INT145102 Positive_regulation of Transcription of Nos3 1 0.45 0.46 0.14
88 INT290701 Protein_catabolism of Nos3 1 0.54 0.42 0.13
89 INT212996 Negative_regulation of Positive_regulation of Nos3 3 0.35 2.11 0.12
90 INT269395 Regulation of Binding of NOS3 2 0.39 1.84 0.12
91 INT323261 Positive_regulation of Binding of Nos3 1 0.18 0.25 0.12
92 INT186558 Negative_regulation of Positive_regulation of NOS3 2 0.37 0.26 0.1
93 INT172791 Negative_regulation of Transcription of Nos3 1 0.17 0.9 0.1
94 INT309385 Positive_regulation of Phosphorylation of Nos3 5 0.48 2.98 0.09
95 INT305235 Negative_regulation of Phosphorylation of Nos3 5 0.41 4.17 0.09
96 INT192238 Positive_regulation of Localization of NOS3 2 0.21 0.76 0.09
97 INT252433 Regulation of Positive_regulation of Adora2b 1 0.44 0 0.09
98 INT241716 Positive_regulation of Transcription of Adora2b 1 0.50 0.28 0.06
99 INT175698 Positive_regulation of Localization of Nos3 2 0.27 1.19 0.04
100 INT343710 Positive_regulation of Localization of Nos3 1 0.38 0.22 0.03
101 INT269496 Regulation of Binding of Nos3 3 0.25 0.46 0
102 INT355212 Positive_regulation of Phosphorylation of Nos3 1 0.23 0.18 0
103 INT336827 Regulation of Regulation of NOS3 1 0.23 0.51 0
104 INT309384 Regulation of Phosphorylation of Nos3 1 0.31 0.39 0
105 INT249944 Positive_regulation of Regulation of Nos3 1 0.35 0.07 0
106 INT174535 Negative_regulation of Negative_regulation of NOS3 1 0.11 0.32 0
107 INT327819 Localization of ADORA2B 1 0.22 0.3 0
108 INT343712 Regulation of Positive_regulation of Nos3 1 0.50 0.93 0
109 INT140156 Positive_regulation of Transcription of NOS3 1 0.31 0 0
110 INT159478 Negative_regulation of Phosphorylation of NOS3 1 0.51 0 0
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