GO:0031293

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Name membrane protein intracellular domain proteolysis
Categary Process
Go Slim No
Go Link GO:0031293
Unique Molecular Interactions 186
Total Molecular Interactions 272
Total Single Events 1733
Pain Genes Associated 9

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for membrane protein intracellular domain proteolysis. They are ordered first by their pain relevance and then by number of times they were reported for membrane protein intracellular domain proteolysis. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT61359 TNF Positive_regulation of NFKB1 11 0.63 6.66 3.89
2 INT81920 Binding of IL1B and NFKB1 1 0.04 1.54 1.85
3 INT81914 Binding of HSF1 and NFKB1 1 0.05 1.54 1.85
4 INT116092 TFF2 Positive_regulation of NFKB1 1 0.17 0.06 1.77
5 INT116093 OPRM1 Positive_regulation of Positive_regulation of NFKB1 1 0.36 0.08 1.56
6 INT59707 PSENEN Regulation of Negative_regulation of YY1 1 0.12 0.07 1.21
7 INT133046 TNF Positive_regulation of Positive_regulation of NFKB1 5 0.54 3.23 1.19
8 INT55162 Binding of NFKB1 and RELA 10 0.30 2.82 1.18
9 INT147447 ADCYAP1 Regulation of Localization of RELA 1 0.50 1.12 1.15
10 INT147448 ADCYAP1 Regulation of Localization of NFKB1 1 0.47 1.12 1.15
11 INT101715 PLAT Positive_regulation of NFKB1 2 0.11 0.99 1.09
12 INT105113 Plat Positive_regulation of NFKB1 1 0.03 1.06 1.06
13 INT156245 NFKB1 Positive_regulation of Regulation of TNF 1 0.45 0.76 1.03
14 INT127672 Binding of NGFR and NTRK1 1 0.17 2.28 0.97
15 INT152388 Binding of NFKB1 and OPRM1 1 0.04 0.14 0.94
16 INT152389 Negative_regulation of Binding of NFKB1 and OPRM1 1 0.05 0.14 0.94
17 INT90387 ROS1 Positive_regulation of NFKB1 4 0.32 2.35 0.87
18 INT161305 NFKB1 Positive_regulation of IL2 1 0.25 0.25 0.83
19 INT106312 NFKB1 Regulation of S100A4 1 0.14 1.1 0.83
20 INT117341 ADAM17 Positive_regulation of EGFR 1 0.16 3.56 0.82
21 INT66206 Negative_regulation of TNF Positive_regulation of NFKB1 2 0.53 1.71 0.81
22 INT140966 NFKB1 Positive_regulation of Positive_regulation of CPOX 1 0.08 0.66 0.8
23 INT104831 Binding of GLI2 and NFKB1 1 0.08 0 0.8
24 INT146463 TNFSF10 Positive_regulation of NFKB1 2 0.08 2.45 0.71
25 INT146461 IFNG Positive_regulation of NFKB1 1 0.01 1.44 0.71
26 INT153123 NFKBIA Negative_regulation of Phosphorylation of RELA 1 0.03 2.01 0.71
27 INT103134 DCSTAMP Positive_regulation of NFKB1 2 0.07 1.43 0.7
28 INT160119 EPO Regulation of Gene_expression of NFKB1 1 0.02 0.2 0.64
29 INT120851 NFKB1 Positive_regulation of Localization of TNF 3 0.04 2.05 0.62
30 INT66207 Positive_regulation of TNF Positive_regulation of NFKB1 1 0.42 0.08 0.61
31 INT144248 CGA Regulation of Positive_regulation of NFKB1 1 0.15 1.66 0.61
32 INT144256 CGA Regulation of Gene_expression of NFKB1 1 0.21 1.66 0.61
33 INT147071 NFKB1 Regulation of Gene_expression of PTGES 1 0.36 0.35 0.57
34 INT113548 NFKB1 Regulation of Localization of PLAU 1 0.26 1.93 0.55
35 INT156246 NFKB1 Regulation of Gene_expression of TNF 1 0.17 0.35 0.54
36 INT105111 Negative_regulation of Plat Positive_regulation of NFKB1 1 0.03 0.53 0.54
37 INT105110 Cxcl12 Positive_regulation of NFKB1 1 0.06 0.54 0.53
38 INT105108 Negative_regulation of Cxcl12 Positive_regulation of NFKB1 1 0.05 0.54 0.53
39 INT139834 NFKB1 Regulation of Gene_expression of SELE 1 0.18 0.49 0.5
40 INT139835 NFKB1 Regulation of SELE 1 0.41 0.49 0.5
41 INT127677 NGF Regulation of Gene_expression of NGFR 1 0.20 1.11 0.5
42 INT106072 NFKB1 Positive_regulation of Gene_expression of A2M 1 0.19 0.75 0.49
43 INT135588 Positive_regulation of IKBKE Positive_regulation of NFKB1 1 0.18 1.29 0.48
44 INT135587 IKBKE Positive_regulation of NFKB1 1 0.18 1.28 0.48
45 INT191948 NFKB1 Regulation of Gene_expression of NOS2 1 0.38 1 0.47
46 INT106073 IL1B Positive_regulation of Positive_regulation of NFKB1 1 0.41 0.7 0.47
47 INT144245 CGA Negative_regulation of Positive_regulation of NFKB1 1 0.13 0.79 0.45
48 INT103128 Positive_regulation of DCSTAMP Positive_regulation of NFKB1 1 0.07 0.73 0.43
49 INT107704 IL1B Positive_regulation of Localization of RELA 1 0.02 0.13 0.41
50 INT261652 Binding of MAPK1 and PSEN1 1 0.22 1.25 0.41
51 INT107699 IL1B Positive_regulation of Localization of NFKB1 1 0.03 0.13 0.41
52 INT84516 NFKB1 Positive_regulation of Gene_expression of TF 1 0.10 0.09 0.41
53 INT103131 Positive_regulation of NFKB1 Regulation of Gene_expression of IL8 1 0.27 0.68 0.4
54 INT166788 HRAS Negative_regulation of Phosphorylation of NFKB1 1 0.08 0.5 0.39
55 INT103795 Negative_regulation of SLC9A1 Negative_regulation of Positive_regulation of NFKB1 1 0.12 0.47 0.37
56 INT107705 DCSTAMP Positive_regulation of Localization of NFKB1 1 0.07 0.07 0.36
57 INT54570 Positive_regulation of NFKB1 Positive_regulation of Gene_expression of IL8 1 0.24 0.77 0.35
58 INT90388 NFKB1 Positive_regulation of CPOX 1 0.32 0.18 0.35
59 INT83347 GSR Negative_regulation of NFKB1 1 0.25 0.72 0.33
60 INT144251 TNF Positive_regulation of Gene_expression of NFKB1 1 0.43 0.65 0.3
61 INT80029 Binding of FAS and Positive_regulation of NFKB1 1 0.34 0.92 0.3
62 INT140386 Spp1 Positive_regulation of NFKB1 1 0.21 1.29 0.3
63 INT166789 HRAS Regulation of Positive_regulation of NFKB1 1 0.05 0.31 0.3
64 INT80031 FAS Positive_regulation of Positive_regulation of NFKB1 1 0.50 0.93 0.3
65 INT113558 Negative_regulation of NFKB1 Negative_regulation of Localization of PLAU 1 0.41 0.97 0.29
66 INT129291 Positive_regulation of OPRM1 Positive_regulation of Phosphorylation of RELA 1 0.06 0.27 0.28
67 INT196631 PTGER2 Negative_regulation of NFKB1 1 0.00 0.32 0.28
68 INT323710 TRAF6 Regulation of MIR146A 1 0.06 0.55 0.28
69 INT144237 Negative_regulation of DCSTAMP Positive_regulation of NFKB1 1 0.06 0.72 0.28
70 INT144255 EGF Regulation of Positive_regulation of NFKB1 1 0.41 0.66 0.27
71 INT144239 CTSG Regulation of Positive_regulation of NFKB1 1 0.00 0.67 0.27
72 INT56071 NFKB1 Positive_regulation of Gene_expression of IL1B 1 0.36 0.4 0.27
73 INT125514 Positive_regulation of PRKDC Positive_regulation of Positive_regulation of NFKB1 1 0.07 0.44 0.26
74 INT125512 Gene_expression of NFKB1 Positive_regulation of GDF15 1 0.32 0.42 0.25
75 INT321224 TLR4 Positive_regulation of NFKB1 1 0.04 1.02 0.25
76 INT120849 PRL Positive_regulation of NFKB1 1 0.07 0.49 0.25
77 INT321223 CXCR1 Positive_regulation of NFKB1 1 0.00 1.02 0.25
78 INT321222 Binding of NFKB1 and NFKBIZ 1 0.02 1.11 0.24
79 INT125518 Binding of NFKB1 and GDF15 1 0.33 0.41 0.24
80 INT125519 Regulation of PLAT Positive_regulation of NFKB1 1 0.07 0.44 0.24
81 INT143950 Negative_regulation of NFKB1 Positive_regulation of Gene_expression of RELA 1 0.45 0.46 0.23
82 INT144238 TNF Positive_regulation of Protein_catabolism of NFKB1 1 0.40 0.35 0.22
83 INT104838 Binding of NFKB1 and IGKV2OR2-1 1 0.01 0 0.22
84 INT55164 Binding of NFKB1 and WRAP53 1 0.02 0.11 0.19
85 INT146687 Regulation of Binding of App and Aph1a 1 0.16 0.58 0.19
86 INT146686 Binding of App and Aph1a 1 0.14 0.58 0.19
87 INT340447 Negative_regulation of IRF6 Positive_regulation of RELA 1 0.00 0.87 0.18
88 INT102805 NFKB1 Regulation of TCEAL1 1 0.25 0.77 0.17
89 INT116442 CD8B Negative_regulation of Positive_regulation of NFKB1 1 0.02 0 0.17
90 INT144252 CGA Positive_regulation of Positive_regulation of NFKB1 1 0.17 0.38 0.17
91 INT334106 APC Negative_regulation of NFKB1 1 0.25 1.37 0.17
92 INT116443 LY9 Negative_regulation of Positive_regulation of NFKB1 1 0.12 0 0.17
93 INT102806 NFKB1 Regulation of Gene_expression of TCEAL1 1 0.25 0.77 0.17
94 INT160539 Binding of NGF and NGFR 1 0.06 0.46 0.17
95 INT160542 Binding of BDNF and NGFR 1 0.08 0.46 0.17
96 INT102804 NFKB1 Regulation of TP53 1 0.35 0.77 0.17
97 INT102803 NFKB1 Regulation of Gene_expression of TP53 1 0.35 0.77 0.17
98 INT340448 IRF6 Positive_regulation of RELA 1 0.00 0.86 0.17
99 INT296030 Binding of NFKB1 and FOXP3 1 0.17 1.18 0.16
100 INT350013 ARID1B Regulation of Positive_regulation of NFKB1 1 0.00 1.77 0.16
101 INT296078 Binding of NFKB1 and Gtf3a 1 0.00 1.18 0.16
102 INT104832 Binding of IL10 and NFKB1 1 0.15 0 0.15
103 INT139822 ZNF833P Negative_regulation of Transcription of NFKB1 1 0.03 0.11 0.15
104 INT139821 ZNF833P Negative_regulation of Localization of RELA 1 0.00 0.11 0.15
105 INT61360 Regulation of TNF Positive_regulation of NFKB1 2 0.21 1.34 0.14
106 INT182780 NFKB1 Positive_regulation of IL1B 1 0.00 1.8 0.14
107 INT214480 SELPLG Negative_regulation of Positive_regulation of NFKB1 1 0.00 0.6 0.14
108 INT94763 PSEN2 Regulation of Positive_regulation of App 1 0.11 0.72 0.14
109 INT182782 NFKB1 Positive_regulation of IL6 1 0.00 1.8 0.14
110 INT139791 PRSS53 Negative_regulation of NFKB1 1 0.09 0.71 0.13
111 INT128281 Binding of JUND and NFKB1 1 0.36 0.39 0.13
112 INT306262 NFKB1 Positive_regulation of Transcription of PTGS2 1 0.42 0.31 0.12
113 INT306265 Binding of NFKB1 and NFKBIA 1 0.21 0.48 0.11
114 INT147073 NFKB1 Regulation of PTGS2 1 0.37 0 0.11
115 INT147072 NFKB1 Regulation of PTGES 1 0.36 0 0.11
116 INT139784 PRSS53 Negative_regulation of Positive_regulation of NFKB1 1 0.09 0.9 0.11
117 INT139785 TNFAIP8 Positive_regulation of Positive_regulation of NFKB1 1 0.19 0.89 0.11
118 INT55163 Binding of RELA and WRAP53 1 0.01 0.05 0.1
119 INT294681 Tlr4 Positive_regulation of Positive_regulation of NFKB1 1 0.02 0.27 0.1
120 INT243685 NDUFA2 Negative_regulation of Localization of RELA 1 0.07 0 0.09
121 INT234222 PSEN1 Regulation of Gene_expression of NOTCH1 1 0.03 0 0.08
122 INT353070 ADAM17 Positive_regulation of TNF 1 0.19 1.66 0.08
123 INT208218 NFKB1 Regulation of IRF6 1 0.01 0.07 0.07
124 INT208219 RELA Regulation of IRF6 1 0.00 0.07 0.07
125 INT193967 Binding of PSEN1 and Psen1 1 0.41 1.2 0.05
126 INT193970 Binding of PSEN1 and Psen2 1 0.36 2.06 0.05
127 INT340271 Fig4 Positive_regulation of Localization of RELA 1 0.01 0.68 0.04
128 INT331477 PSEN2 Regulation of Gene_expression of Psen1 1 0.00 0.15 0.03
129 INT331478 Psen1 Regulation of Gene_expression of PSEN2 1 0.00 0.15 0.03
130 INT172716 Binding of BCL3 and NFKB1 1 0.06 0.15 0.03
131 INT340276 Tnfsf11 Positive_regulation of Localization of RELA 1 0.02 0.58 0.03
132 INT139004 Mtpn Regulation of NFKB1 1 0.33 0.55 0
133 INT315052 Binding of IL8 and RELA 1 0.07 0.34 0
134 INT95305 RELA Positive_regulation of Nfkb1 1 0.00 0.08 0
135 INT103286 Negative_regulation of IRF6 Positive_regulation of NFKB1 1 0.18 0 0
136 INT103287 IRF6 Positive_regulation of NFKB1 1 0.19 0 0
137 INT165509 CYBB Regulation of Gene_expression of NFKB1 1 0.02 0 0
138 INT156450 ANGPTL5 Positive_regulation of Positive_regulation of NFKB1 1 0.03 0 0
139 INT315053 Negative_regulation of AKT1 Positive_regulation of Binding of RELA 1 0.10 0.12 0
140 INT155918 NFKB1 Positive_regulation of Gene_expression of TNF 1 0.34 0 0
141 INT155173 NFKB1 Regulation of Gene_expression of NOS1 1 0.12 0.08 0
142 INT150957 STK16 Positive_regulation of Positive_regulation of NFKB1 1 0.04 0.08 0
143 INT334644 Binding of PSEN1 and TTN 1 0.01 0 0
144 INT217402 Binding of Bace1 and PSENEN 1 0.02 0.72 0
145 INT350098 Gene_expression of PSEN2 Positive_regulation of Gene_expression of Hmox1 1 0.39 0 0
146 INT95308 Binding of RELA and Nfkb1 1 0.00 0.08 0
147 INT170586 CD40 Negative_regulation of Positive_regulation of RELA 1 0.12 0.24 0
148 INT197816 Binding of MEN1 and NFKB1 1 0.05 0.07 0
149 INT95306 Negative_regulation of RELA Positive_regulation of Nfkb1 1 0.00 0.08 0
150 INT155926 PARP1 Regulation of Binding of NFKB1 1 0.24 0.16 0
151 INT315064 Binding of RELA and PAR4 1 0.08 0.45 0
152 INT55165 Binding of REL and RELA 1 0.16 0.18 0
153 INT315070 Binding of IL8 and NFKB1 1 0.26 0.34 0
154 INT170590 RELA Negative_regulation of Gene_expression of ICAM1 1 0.42 0.49 0
155 INT349543 Tnfsf10 Positive_regulation of NGFR 1 0.01 0.43 0
156 INT165510 HSPG2 Negative_regulation of Gene_expression of NFKB1 1 0.01 0.06 0
157 INT193968 Binding of PSEN1 and Ps 1 0.07 0.66 0
158 INT292159 Binding of NFKB2 and RELA 1 0.02 0.4 0
159 INT170588 RELA Regulation of Gene_expression of ICAM1 1 0.26 0 0
160 INT55166 Binding of PROC and RELA 1 0.01 0.09 0
161 INT335513 EDIL3 Regulation of NFKB1 1 0.26 0.2 0
162 INT95307 Negative_regulation of Binding of RELA and Nfkb1 1 0.00 0.08 0
163 INT286337 PSENEN Regulation of Psen1 1 0.07 0.37 0
164 INT95304 Positive_regulation of Binding of RELA and Nfkb1 1 0.00 0.08 0
165 INT170589 NFKB1 Regulation of Gene_expression of ICAM1 1 0.27 0 0
166 INT156451 Negative_regulation of NFKB1 Negative_regulation of Gene_expression of ANGPTL5 1 0.03 0 0
167 INT292152 Binding of NFKB1 and REL 1 0.03 0.4 0
168 INT155922 PARP1 Positive_regulation of Binding of NFKB1 1 0.42 0.06 0
169 INT155924 Binding of PARP1 and NFKB1 1 0.34 0.23 0
170 INT294428 PSEN2 Regulation of Gene_expression of Tp53 1 0.49 0.86 0
171 INT315062 Positive_regulation of Binding of RELA and PAR4 1 0.11 0.12 0
172 INT294429 PSEN2 Negative_regulation of Tp53 1 0.46 1.03 0
173 INT331479 Binding of PSEN2 and Psen1 1 0.00 0.07 0
174 INT175193 NUP62 Regulation of Binding of TRAF6 1 0.07 0.06 0
175 INT164070 AKT1 Positive_regulation of NFKB1 1 0.32 0.09 0
176 INT164071 AKT1 Regulation of Positive_regulation of NFKB1 1 0.17 0.09 0
177 INT315051 AKT1 Regulation of Localization of RELA 1 0.09 0.07 0
178 INT234221 Negative_regulation of PSEN1 Negative_regulation of Gene_expression of APP 1 0.33 0.32 0
179 INT155917 NFKB1 Positive_regulation of Gene_expression of IL6 1 0.29 0 0
180 INT155925 PARP1 Positive_regulation of NFKB1 1 0.42 0.06 0
181 INT197814 Binding of MEN1 and RELA 1 0.42 0.07 0
182 INT356107 Binding of Ncstn and Aph1a 1 0.05 0.06 0
183 INT334645 Binding of PSEN1 and HM13 1 0.01 0 0
184 INT175191 Binding of TRAF6 and NUP62 1 0.06 0.06 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for membrane protein intracellular domain proteolysis. They are ordered first by their pain relevance and then by number of times they were reported in membrane protein intracellular domain proteolysis. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT54571 Positive_regulation of NFKB1 263 0.70 138.99 87.32
2 INT56072 Negative_regulation of NFKB1 94 0.59 53.16 28.19
3 INT55170 Gene_expression of NFKB1 97 0.77 52.75 23.04
4 INT66208 Positive_regulation of Positive_regulation of NFKB1 45 0.68 20.17 22.62
5 INT25517 Regulation of NFKB1 41 0.61 22.28 16.09
6 INT54572 Negative_regulation of Positive_regulation of NFKB1 46 0.58 21.45 15.47
7 INT39733 Localization of NFKB1 59 0.79 22.76 13.99
8 INT55168 Binding of NFKB1 55 0.48 22.94 13.15
9 INT66213 Localization of RELA 63 0.78 14.71 8.77
10 INT91772 Gene_expression of PSEN1 115 0.75 38.12 8.48
11 INT66210 Regulation of Positive_regulation of NFKB1 16 0.60 9.46 7.08
12 INT130875 Gene_expression of ADAM17 13 0.78 15.46 6.41
13 INT78728 Negative_regulation of Binding of NFKB1 18 0.58 6.89 5.39
14 INT66209 Negative_regulation of Localization of NFKB1 23 0.58 8.2 5.31
15 INT66211 Positive_regulation of Localization of NFKB1 20 0.68 8.18 5.01
16 INT96492 Gene_expression of NGFR 24 0.00 12.3 4.59
17 INT55171 Gene_expression of RELA 80 0.75 17.17 4.47
18 INT56077 Protein_catabolism of NFKB1 16 0.98 8.03 3.94
19 INT56075 Transcription of NFKB1 13 0.71 9.03 3.83
20 INT79231 Positive_regulation of Gene_expression of NFKB1 18 0.67 9.16 3.66
21 INT134149 Negative_regulation of Gene_expression of NFKB1 7 0.55 4.25 3.63
22 INT12385 Localization of NGFR 6 0.81 3.05 3.47
23 INT73557 Positive_regulation of RELA 57 0.46 8.7 3.43
24 INT211591 Negative_regulation of PSEN1 14 0.57 5.73 3.26
25 INT139801 Phosphorylation of NFKB1 9 0.66 5.2 3.13
26 INT66212 Negative_regulation of Localization of RELA 13 0.57 2.48 3.09
27 INT91761 Gene_expression of PSEN2 38 0.75 22.93 3.03
28 INT193936 Positive_regulation of PSEN1 5 0.58 11.57 2.95
29 INT209889 Gene_expression of TRAF6 13 0.63 6.85 2.67
30 INT71305 Regulation of Gene_expression of NFKB1 9 0.61 5.41 2.44
31 INT123530 Phosphorylation of RELA 9 0.80 3.46 1.99
32 INT193939 Binding of PSEN1 10 0.36 6.16 1.93
33 INT117346 Positive_regulation of ADAM17 5 0.50 6.69 1.86
34 INT56078 Negative_regulation of Protein_catabolism of NFKB1 7 0.42 4.44 1.83
35 INT130874 Negative_regulation of Gene_expression of ADAM17 3 0.43 5.03 1.76
36 INT76608 Regulation of Negative_regulation of NFKB1 1 0.33 0.53 1.75
37 INT55169 Binding of RELA 40 0.36 4.91 1.74
38 INT108875 Positive_regulation of Localization of RELA 9 0.49 1.43 1.72
39 INT99258 Regulation of Aph1a 3 0.25 2.79 1.68
40 INT165446 Positive_regulation of Phosphorylation of NFKB1 3 0.56 1.88 1.66
41 INT127679 Positive_regulation of Gene_expression of NGFR 7 0.67 4.98 1.43
42 INT110252 Positive_regulation of Gene_expression of RELA 29 0.49 6.36 1.31
43 INT137811 Negative_regulation of NGFR 4 0.50 2.22 1.28
44 INT66214 Regulation of Binding of NFKB1 2 0.35 0.55 1.28
45 INT56127 Positive_regulation of NGFR 8 0.49 5.3 1.27
46 INT12386 Binding of NGFR 6 0.48 2.15 1.22
47 INT59711 Negative_regulation of Positive_regulation of PSENEN 1 0.17 0.07 1.21
48 INT59712 Positive_regulation of PSENEN 3 0.21 0.23 1.19
49 INT132435 Negative_regulation of ADAM17 2 0.50 3.75 1.02
50 INT91771 Positive_regulation of Gene_expression of PSEN1 13 0.49 8.93 0.93
51 INT88600 Positive_regulation of Binding of NFKB1 9 0.59 2.1 0.88
52 INT29981 Binding of PSENEN 2 0.17 0.24 0.86
53 INT115441 Positive_regulation of Aph1a 1 0.02 0.46 0.82
54 INT76609 Regulation of Regulation of NFKB1 2 0.20 0.97 0.79
55 INT94756 Positive_regulation of PSEN2 8 0.49 4.59 0.77
56 INT56073 Positive_regulation of Transcription of NFKB1 4 0.46 1.88 0.77
57 INT8146 Gene_expression of PSENEN 2 0.14 0.89 0.75
58 INT143427 Regulation of NGFR 1 0.26 1.65 0.73
59 INT56074 Negative_regulation of Transcription of NFKB1 3 0.58 1.53 0.64
60 INT91765 Positive_regulation of Gene_expression of PSEN2 8 0.49 4.57 0.63
61 INT108874 Regulation of Localization of RELA 5 0.44 1.09 0.61
62 INT138678 Transcription of ADAM17 1 0.69 4.9 0.56
63 INT107106 Positive_regulation of Negative_regulation of NFKB1 1 0.33 1.26 0.54
64 INT217394 Regulation of Binding of PSEN1 1 0.44 1.58 0.53
65 INT138676 Localization of ADAM17 4 0.73 4.91 0.5
66 INT73559 Negative_regulation of Positive_regulation of RELA 2 0.36 1.37 0.49
67 INT121118 Regulation of Protein_catabolism of Aph1a 1 0.06 0.35 0.45
68 INT121119 Protein_catabolism of Aph1a 1 0.13 0.35 0.45
69 INT234249 Regulation of PSEN1 6 0.37 2.21 0.43
70 INT234257 Regulation of Gene_expression of PSEN1 6 0.44 1.98 0.42
71 INT209891 Regulation of Gene_expression of TRAF6 2 0.22 1.4 0.41
72 INT166794 Regulation of Localization of NFKB1 2 0.36 0.49 0.38
73 INT166795 Regulation of Phosphorylation of NFKB1 1 0.36 0.49 0.38
74 INT177773 Localization of PSEN1 4 0.73 0.89 0.36
75 INT261682 Positive_regulation of Positive_regulation of PSEN2 1 0.21 0.55 0.33
76 INT127678 Transcription of NGFR 1 0.29 0.9 0.33
77 INT73555 Negative_regulation of RELA 5 0.41 0.57 0.32
78 INT129297 Positive_regulation of Phosphorylation of RELA 1 0.24 0.33 0.29
79 INT224298 Negative_regulation of PSEN2 6 0.57 2.29 0.28
80 INT209886 Positive_regulation of TRAF6 2 0.39 1.27 0.28
81 INT323753 Negative_regulation of Gene_expression of TRAF6 1 0.21 0.52 0.26
82 INT170600 Negative_regulation of Gene_expression of RELA 16 0.39 1.29 0.25
83 INT170596 Regulation of RELA 4 0.41 0.39 0.25
84 INT261676 Negative_regulation of Positive_regulation of PSEN1 1 0.36 1.59 0.25
85 INT172525 Localization of PSEN2 5 0.73 4.17 0.24
86 INT170594 Regulation of Gene_expression of RELA 6 0.41 0.15 0.22
87 INT170607 Positive_regulation of Positive_regulation of RELA 4 0.46 1.49 0.21
88 INT323720 Negative_regulation of TRAF6 1 0.21 0.41 0.21
89 INT170602 Positive_regulation of Binding of RELA 5 0.46 0.32 0.2
90 INT143955 Negative_regulation of Negative_regulation of NFKB1 1 0.35 0.48 0.2
91 INT343887 Positive_regulation of Gene_expression of TRAF6 1 0.16 0.21 0.19
92 INT138679 Regulation of ADAM17 1 0.19 1.13 0.16
93 INT138680 Binding of ADAM17 1 0.36 1.42 0.16
94 INT323747 Regulation of TRAF6 1 0.13 1.15 0.14
95 INT323728 Phosphorylation of TRAF6 1 0.39 0.79 0.12
96 INT176595 Negative_regulation of Gene_expression of PSEN2 1 0.24 1.01 0.11
97 INT170597 Negative_regulation of Regulation of RELA 1 0.39 0 0.11
98 INT201694 Negative_regulation of Gene_expression of PSEN1 3 0.41 2.31 0.1
99 INT138677 Negative_regulation of Transcription of ADAM17 1 0.42 1.18 0.1
100 INT109131 Regulation of PSEN2 3 0.44 0.55 0.08
101 INT170593 Transcription of RELA 3 0.63 0.92 0.08
102 INT175210 Binding of TRAF6 2 0.17 0.73 0.08
103 INT286316 Gene_expression of Aph1a 1 0.33 0.1 0.08
104 INT261678 Positive_regulation of Positive_regulation of PSEN1 1 0.42 0.62 0.08
105 INT193938 Phosphorylation of PSEN1 5 0.79 1.6 0.07
106 INT176592 Transcription of PSEN2 5 0.33 0.41 0.05
107 INT285151 Regulation of Localization of NGFR 1 0.02 0.24 0.05
108 INT224302 Negative_regulation of Transcription of PSEN2 3 0.26 0.08 0
109 INT186335 Protein_catabolism of RELA 2 0.86 0.71 0
110 INT265229 Binding of PSEN2 2 0.16 1.37 0
111 INT143428 Negative_regulation of Gene_expression of NGFR 1 0.57 0 0
112 INT234250 Positive_regulation of Negative_regulation of PSEN1 1 0.41 0 0
113 INT312059 Negative_regulation of Binding of RELA 1 0.43 0 0
114 INT193934 Positive_regulation of Binding of PSEN1 1 0.49 0.92 0
115 INT224297 Regulation of Transcription of PSEN2 1 0.20 0.06 0
116 INT177774 Transcription of PSEN1 1 0.33 0.09 0
117 INT186330 Positive_regulation of Protein_catabolism of RELA 1 0.49 0.55 0
118 INT286336 Positive_regulation of Gene_expression of PSENEN 1 0.10 0.39 0
119 INT150261 Negative_regulation of Aph1a 1 0.00 0.37 0
120 INT286334 Localization of PSENEN 1 0.14 0.31 0
121 INT286335 Positive_regulation of Binding of PSENEN 1 0.10 0.15 0
122 INT286315 Positive_regulation of Gene_expression of Aph1a 1 0.19 0 0
123 INT331463 Regulation of Gene_expression of PSEN2 1 0.04 0 0
124 INT288036 Negative_regulation of Phosphorylation of RELA 1 0.07 0.13 0
125 INT234258 Negative_regulation of Phosphorylation of PSEN1 1 0.35 0.49 0
126 INT288035 Regulation of Binding of RELA 1 0.04 0 0
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